Guy S. Salvesen - Publications

Molecular Pathology University of California, San Diego, La Jolla, CA 
Biochemistry, Cell Biology, Molecular Biology

216 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Kasperkiewicz P, Hempel A, Janiszewski T, Kołt S, Snipas SJ, Drag M, Salvesen GS. NETosis occurs independently of neutrophil serine proteases. The Journal of Biological Chemistry. 295: 17624-17631. PMID 33454002 DOI: 10.1074/jbc.RA120.015682  0.36
2020 Kasperkiewicz P, Hempel A, Janiszewski T, Kolt S, Snipas SJ, Drag M, Salvesen GS. NETosis Occurs Independently of Neutrophil Serine Proteases. The Journal of Biological Chemistry. PMID 33060201 DOI: 10.1074/jbc.RA120.015682  0.36
2020 Poreba M, Groborz KM, Rut W, Pore M, Snipas SJ, Vizovisek M, Turk B, Kuhn P, Drag M, Salvesen GS. Multiplexed Probing of Proteolytic Enzymes Using Mass Cytometry-Compatible Activity-Based Probes. Journal of the American Chemical Society. PMID 32870676 DOI: 10.1021/jacs.0c06762  0.36
2020 Razai AS, Snipas SJ, Poreba M, Fasci D, Salvesen GS. Engineering Caspase 7 as an Affinity Reagent to Capture Proteolytic Products. The Febs Journal. PMID 32619291 DOI: 10.1111/febs.15467  0.68
2020 Bibo-Verdugo B, Snipas SJ, Kolt S, Poreba M, Salvesen GS. Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11. The Journal of Biological Chemistry. PMID 32554464 DOI: 10.1074/jbc.RA120.014259  0.36
2020 Tom I, Pham VC, Katschke KJ, Li W, Liang WC, Gutierrez J, Ah Young A, Figueroa I, Eshghi ST, Lee CV, Kanodia J, Snipas SJ, Salvesen GS, Lai P, Honigberg L, et al. Development of a therapeutic anti-HtrA1 antibody and the identification of DKK3 as a pharmacodynamic biomarker in geographic atrophy. Proceedings of the National Academy of Sciences of the United States of America. PMID 32345717 DOI: 10.1073/pnas.1917608117  0.36
2020 Razai AS, Eckelman BP, Salvesen GS. Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody. The Journal of Biological Chemistry. PMID 31953328 DOI: 10.1074/jbc.RA119.011712  0.88
2019 Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H. Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nature Microbiology. PMID 31873204 DOI: 10.1038/s41564-019-0620-5  0.36
2019 Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C. Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation. Cell Reports. 27: 3646-3656.e5. PMID 31216481 DOI: 10.1016/j.celrep.2019.05.065  0.36
2019 Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drąg M, Poręba M. Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells. Cell Death and Differentiation. PMID 31209360 DOI: 10.1038/s41418-019-0364-z  0.36
2019 Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M. Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells. Cell Death and Differentiation. PMID 30976094 DOI: 10.1038/s41418-019-0329-2  0.36
2018 Kasperkiewicz P, Kołt S, Janiszewski T, Groborz K, Poręba M, Snipas SJ, Salvesen GS, Drąg M. Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes. Scientific Reports. 8: 15998. PMID 30375474 DOI: 10.1038/s41598-018-34476-7  0.36
2018 Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS. Caspase selective reagents for diagnosing apoptotic mechanisms. Cell Death and Differentiation. PMID 29748600 DOI: 10.1038/s41418-018-0110-y  0.36
2018 Gonzalez Ramirez ML, Poreba M, Snipas SJ, Groborz K, Drag M, Salvesen GS. Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1. The Journal of Biological Chemistry. PMID 29414788 DOI: 10.1074/jbc.RA117.001329  0.36
2017 Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M. Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families. Scientific Reports. 7: 43135. PMID 28230157 DOI: 10.1038/srep43135  0.36
2016 Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M. Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes. Cell Chemical Biology. PMID 27478158 DOI: 10.1016/j.chembiol.2016.05.020  0.36
2015 Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, ... ... Salvesen GS, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 526: 666-71. PMID 26375259 DOI: 10.1038/nature15541  0.36
2015 Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M. Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4. Plos One. 10: e0132818. PMID 26172376 DOI: 10.1371/journal.pone.0132818  0.36
2015 Fasci D, Anania VG, Lill JR, Salvesen GS. SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML. Science Signaling. 8: ra56. PMID 26060329 DOI: 10.1126/scisignal.aaa3929  0.88
2015 Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS. Probes to monitor activity of the paracaspase MALT1. Chemistry & Biology. 22: 139-47. PMID 25556944 DOI: 10.1016/j.chembiol.2014.11.011  0.88
2015 Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M. Design of a selective substrate and activity based probe for human neutrophil serine protease 4 Plos One. 10. DOI: 10.1371/journal.pone.0132818  0.88
2014 Kumar S, van Raam BJ, Salvesen GS, Cieplak P. Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates. Plos One. 9: e110539. PMID 25330111 DOI: 10.1371/journal.pone.0110539  0.88
2014 Mace PD, Riedl SJ, Salvesen GS. Caspase enzymology and activation mechanisms. Methods in Enzymology. 544: 161-78. PMID 24974290 DOI: 10.1016/B978-0-12-417158-9.00007-8  0.88
2014 Salvesen GS, Walsh CM. Functions of caspase 8: the identified and the mysterious. Seminars in Immunology. 26: 246-52. PMID 24856110 DOI: 10.1016/j.smim.2014.03.005  0.88
2014 Poreba M, Kasperkiewicz P, Snipas SJ, Fasci D, Salvesen GS, Drag M. Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates Cell Death and Differentiation. 21: 1482-1492. PMID 24832467 DOI: 10.1038/cdd.2014.64  0.88
2014 Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G. Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation. The Journal of Biological Chemistry. 289: 15544-53. PMID 24713703 DOI: 10.1074/jbc.M113.507616  0.88
2014 Byzia A, Haeggström JZ, Salvesen GS, Drag M. A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids. Amino Acids. 46: 1313-20. PMID 24573245 DOI: 10.1007/s00726-014-1694-2  0.88
2014 Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M. Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling. Proceedings of the National Academy of Sciences of the United States of America. 111: 2518-23. PMID 24550277 DOI: 10.1073/pnas.1318548111  0.88
2014 Salvesen GS. Dying from within: Granzyme B converts entosis to emperitosis Cell Death and Differentiation. 21: 3-4. PMID 24317271 DOI: 10.1038/cdd.2013.157  0.88
2013 Poreba M, Strózyk A, Salvesen GS, Drag M. Caspase substrates and inhibitors. Cold Spring Harbor Perspectives in Biology. 5: a008680. PMID 23788633 DOI: 10.1101/cshperspect.a008680  0.88
2013 Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND. Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP. Acs Chemical Biology. 8: 725-32. PMID 23323685 DOI: 10.1021/cb3005512  0.88
2013 Van Raam BJ, Ehrnhoefer DE, Hayden MR, Salvesen GS. Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6 Cell Death and Differentiation. 20: 86-96. PMID 22858542 DOI: 10.1038/cdd.2012.98  0.88
2013 Salvesen GS. Cathepsin G Handbook of Proteolytic Enzymes. 3: 2661-2666. DOI: 10.1016/B978-0-12-382219-2.00588-3  0.88
2013 van Raam BJ, Salvesen GS. Caspase-9 Handbook of Proteolytic Enzymes. 2: 2252-2255. DOI: 10.1016/B978-0-12-382219-2.00506-8  0.88
2013 van Raam BJ, Salvesen GS. Caspase-8 and Caspase-10 Handbook of Proteolytic Enzymes. 2: 2248-2252. DOI: 10.1016/B978-0-12-382219-2.00505-6  0.88
2012 Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS. Activity, specificity, and probe design for the smallpox virus protease K7L. The Journal of Biological Chemistry. 287: 39470-9. PMID 23012361 DOI: 10.1074/jbc.M112.388678  0.88
2012 Salvesen GS, Bogyo M. Highlight: the universe of proteolytic networks and mechanisms. Biological Chemistry. 393: 841. PMID 22944685 DOI: 10.1515/hsz-2012-0262  0.88
2012 Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S. X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP. Journal of Molecular Biology. 422: 495-507. PMID 22709581 DOI: 10.1016/j.jmb.2012.06.006  0.88
2012 Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU. Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis. The Journal of Biological Chemistry. 287: 21142-51. PMID 22528489 DOI: 10.1074/jbc.M111.306399  0.88
2012 Rickert RC, Salvesen GS, Ware CF. Mousing around with caspases and IAPs. The Biochemical Journal. 443: e1-2. PMID 22452818 DOI: 10.1042/BJ20120402  0.88
2012 Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M. An optimized activity-based probe for the study of caspase-6 activation. Chemistry & Biology. 19: 340-52. PMID 22444589 DOI: 10.1016/j.chembiol.2011.12.021  0.88
2012 Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR. Mitochondrial pathway of apoptosis is ancestral in metazoans. Proceedings of the National Academy of Sciences of the United States of America. 109: 4904-9. PMID 22416118 DOI: 10.1073/pnas.1120680109  0.88
2012 Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M. Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum. Plos One. 7: e31938. PMID 22359643 DOI: 10.1371/journal.pone.0031938  0.88
2012 Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS. Mechanism and specificity of the human paracaspase MALT1. The Biochemical Journal. 443: 287-95. PMID 22309193 DOI: 10.1042/BJ20120035  0.88
2012 Dobrotă C, Fasci D, Hădade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen GS, Funeriu DP. Glycine fluoromethylketones as SENP-specific activity based probes. Chembiochem : a European Journal of Chemical Biology. 13: 80-4. PMID 22134988 DOI: 10.1002/cbic.201100645  0.88
2012 Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M. S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors. Biochimie. 94: 704-10. PMID 22085501 DOI: 10.1016/j.biochi.2011.10.014  0.88
2012 van Raam BJ, Salvesen GS. Proliferative versus apoptotic functions of caspase-8 Hetero or homo: the caspase-8 dimer controls cell fate. Biochimica Et Biophysica Acta. 1824: 113-22. PMID 21704196 DOI: 10.1016/j.bbapap.2011.06.005  0.88
2011 Salvesen GS, Ashkenazi A. Snapshot: caspases. Cell. 147: 476-476.e1. PMID 22000022 DOI: 10.1016/j.cell.2011.09.030  0.88
2011 Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS. RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts. Molecular Cell. 44: 9-16. PMID 21981915 DOI: 10.1016/j.molcel.2011.09.003  0.88
2011 Lu JV, Weist BM, van Raam BJ, Marro BS, Nguyen LV, Srinivas P, Bell BD, Luhrs KA, Lane TE, Salvesen GS, Walsh CM. Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity. Proceedings of the National Academy of Sciences of the United States of America. 108: 15312-7. PMID 21876153 DOI: 10.1073/pnas.1102779108  0.88
2011 Albrow VE, Ponder EL, Fasci D, Békés M, Deu E, Salvesen GS, Bogyo M. Development of small molecule inhibitors and probes of human SUMO deconjugating proteases. Chemistry & Biology. 18: 722-32. PMID 21700208 DOI: 10.1016/j.chembiol.2011.05.008  0.88
2011 Ponder EL, Albrow VE, Leader BA, Békés M, Mikolajczyk J, Fonović UP, Shen A, Drag M, Xiao J, Deu E, Campbell AJ, Powers JC, Salvesen GS, Bogyo M. Functional characterization of a SUMO deconjugating protease of Plasmodium falciparum using newly identified small molecule inhibitors. Chemistry & Biology. 18: 711-21. PMID 21700207 DOI: 10.1016/j.chembiol.2011.04.010  0.88
2011 Akpan N, Serrano-Saiz E, Zacharia BE, Otten ML, Ducruet AF, Snipas SJ, Liu W, Velloza J, Cohen G, Sosunov SA, Frey WH, Salvesen GS, Connolly ES, Troy CM. Intranasal delivery of caspase-9 inhibitor reduces caspase-6-dependent axon/neuron loss and improves neurological function after stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 8894-904. PMID 21677173 DOI: 10.1523/JNEUROSCI.0698-11.2011  0.88
2011 Timmer JC, Salvesen GS. N-terminomics: a high-content screen for protease substrates and their cleavage sites. Methods in Molecular Biology (Clifton, N.J.). 753: 243-55. PMID 21604127 DOI: 10.1007/978-1-61779-148-2_16  0.88
2011 Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR. Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis. Nature. 471: 363-7. PMID 21368763 DOI: 10.1038/nature09852  0.88
2011 Zervoudi E, Papakyriakou A, Georgiadou D, Evnouchidou I, Gajda A, Poreba M, Salvesen GS, Drag M, Hattori A, Swevers L, Vourloumis D, Stratikos E. Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides. The Biochemical Journal. 435: 411-20. PMID 21314638 DOI: 10.1042/BJ20102049  0.88
2011 Békés M, Prudden J, Srikumar T, Raught B, Boddy MN, Salvesen GS. The dynamics and mechanism of SUMO chain deconjugation by SUMO-specific proteases. The Journal of Biological Chemistry. 286: 10238-47. PMID 21247896 DOI: 10.1074/jbc.M110.205153  0.88
2011 Petroski MD, Salvesen GS, Wolf DA. Urm1 couples sulfur transfer to ubiquitin-like protein function in oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 108: 1749-50. PMID 21245332 DOI: 10.1073/pnas.1019043108  0.88
2011 Pop C, Oberst A, Drag M, Van Raam BJ, Riedl SJ, Green DR, Salvesen GS. FLIP(L) induces caspase 8 activity in the absence of interdomain caspase 8 cleavage and alters substrate specificity. The Biochemical Journal. 433: 447-57. PMID 21235526 DOI: 10.1042/BJ20101738  0.88
2011 Leverrier S, Salvesen GS, Walsh CM. Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion Cell Death and Differentiation. 18: 90-98. PMID 20523353 DOI: 10.1038/cdd.2010.69  0.88
2011 Salvesen GS. Human caspases – Apoptosis and inflammation signaling proteases Apoptosis: Physiology and Pathology. 1-10. DOI: 10.1017/CBO9780511976094.001  0.88
2010 Leyva MJ, Degiacomo F, Kaltenbach LS, Holcomb J, Zhang N, Gafni J, Park H, Lo DC, Salvesen GS, Ellerby LM, Ellman JA. Identification and evaluation of small molecule pan-caspase inhibitors in Huntington's disease models. Chemistry & Biology. 17: 1189-200. PMID 21095569 DOI: 10.1016/j.chembiol.2010.08.014  0.88
2010 Chekeni FB, Elliott MR, Sandilos JK, Walk SF, Kinchen JM, Lazarowski ER, Armstrong AJ, Penuela S, Laird DW, Salvesen GS, Isakson BE, Bayliss DA, Ravichandran KS. Pannexin 1 channels mediate 'find-me' signal release and membrane permeability during apoptosis. Nature. 467: 863-7. PMID 20944749 DOI: 10.1038/nature09413  0.88
2010 Bratton SB, Salvesen GS. Regulation of the Apaf-1-caspase-9 apoptosome. Journal of Cell Science. 123: 3209-14. PMID 20844150 DOI: 10.1242/jcs.073643  0.88
2010 Shu CW, Drag M, Bekes M, Zhai D, Salvesen GS, Reed JC. Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4). Autophagy. 6: 936-47. PMID 20818167 DOI: 10.4161/auto.6.7.13075  0.88
2010 Drag M, Salvesen GS. Emerging principles in protease-based drug discovery. Nature Reviews. Drug Discovery. 9: 690-701. PMID 20811381 DOI: 10.1038/nrd3053  0.88
2010 Wachmann K, Pop C, van Raam BJ, Drag M, Mace PD, Snipas SJ, Zmasek C, Schwarzenbacher R, Salvesen GS, Riedl SJ. Activation and specificity of human caspase-10. Biochemistry. 49: 8307-15. PMID 20795673 DOI: 10.1021/bi100968m  0.88
2010 Nakamura T, Wang L, Wong CC, Scott FL, Eckelman BP, Han X, Tzitzilonis C, Meng F, Gu Z, Holland EA, Clemente AT, Okamoto S, Salvesen GS, Riek R, Yates JR, et al. Transnitrosylation of XIAP regulates caspase-dependent neuronal cell death. Molecular Cell. 39: 184-95. PMID 20670888 DOI: 10.1016/j.molcel.2010.07.002  0.88
2010 Enoksson M, Salvesen GS. Metacaspases are not caspases - Always doubt Cell Death and Differentiation. 17: 1221. PMID 20622886 DOI: 10.1038/cdd.2010.45  0.88
2010 Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR. Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation. The Journal of Biological Chemistry. 285: 16632-42. PMID 20308068 DOI: 10.1074/jbc.M109.095083  0.88
2010 Grzywa R, Oleksyszyn J, Salvesen GS, Drag M. Identification of very potent inhibitor of human aminopeptidase N (CD13). Bioorganic & Medicinal Chemistry Letters. 20: 2497-9. PMID 20307982 DOI: 10.1016/j.bmcl.2010.02.111  0.88
2010 van Raam BJ, Salvesen GS. Transferring death: a role for tRNA in apoptosis regulation. Molecular Cell. 37: 591-2. PMID 20227362 DOI: 10.1016/j.molcel.2010.02.001  0.88
2010 Staflin K, Krueger JS, Hachmann J, Forsyth JS, Lorger M, Steiniger SC, Mee J, Pop C, Salvesen GS, Janda KD, Felding-Habermann B. Targeting activated integrin alphavbeta3 with patient-derived antibodies impacts late-stage multiorgan metastasis. Clinical & Experimental Metastasis. 27: 217-31. PMID 20225083 DOI: 10.1007/s10585-010-9320-5  0.88
2010 Zhai D, Yu E, Jin C, Welsh K, Shiau CW, Chen L, Salvesen GS, Liddington R, Reed JC. Vaccinia virus protein F1L is a caspase-9 inhibitor. The Journal of Biological Chemistry. 285: 5569-80. PMID 20022954 DOI: 10.1074/jbc.M109.078113  0.88
2010 Drag M, Bogyo M, Ellman JA, Salvesen GS. Aminopeptidase fingerprints, an integrated approach for identification of good substrates and optimal inhibitors. The Journal of Biological Chemistry. 285: 3310-8. PMID 19948737 DOI: 10.1074/jbc.M109.060418  0.88
2010 Salvesen GS. Caspases. cell signaling by proteolysis Handbook of Cell Signaling, 2/E. 2: 1297-1302. DOI: 10.1016/B978-0-12-374145-5.00162-5  0.88
2009 Walters J, Pop C, Scott FL, Drag M, Swartz P, Mattos C, Salvesen GS, Clark AC. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. The Biochemical Journal. 424: 335-45. PMID 19788411 DOI: 10.1042/BJ20090825  0.88
2009 Timmer JC, Zhu W, Pop C, Regan T, Snipas SJ, Eroshkin AM, Riedl SJ, Salvesen GS. Structural and kinetic determinants of protease substrates. Nature Structural & Molecular Biology. 16: 1101-8. PMID 19767749 DOI: 10.1038/nsmb.1668  0.88
2009 Salvesen GS, Riedl SJ. Structure of the Fas/FADD complex: a conditional death domain complex mediating signaling by receptor clustering. Cell Cycle (Georgetown, Tex.). 8: 2723-7. PMID 19652545 DOI: 10.4161/cc.8.17.9399  0.88
2009 Pop C, Salvesen GS. Human caspases: activation, specificity, and regulation. The Journal of Biological Chemistry. 284: 21777-81. PMID 19473994 DOI: 10.1074/jbc.R800084200  0.88
2009 Békés M, Salvesen GS. The CULt of caspase-8 ubiquitination. Cell. 137: 604-6. PMID 19450509 DOI: 10.1016/j.cell.2009.04.052  0.88
2009 Zhu S, Goeres J, Sixt KM, Békés M, Zhang XD, Salvesen GS, Matunis MJ. Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1. Molecular Cell. 33: 570-80. PMID 19285941 DOI: 10.1016/j.molcel.2009.02.008  0.88
2009 Scott FL, Stec B, Pop C, Dobaczewska MK, Lee JJ, Monosov E, Robinson H, Salvesen GS, Schwarzenbacher R, Riedl SJ. The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature. 457: 1019-22. PMID 19118384 DOI: 10.1038/nature07606  0.88
2009 Timmer AM, Timmer JC, Pence MA, Hsu LC, Ghochani M, Frey TG, Karin M, Salvesen GS, Nizet V. Streptolysin O promotes group A Streptococcus immune evasion by accelerated macrophage apoptosis. The Journal of Biological Chemistry. 284: 862-71. PMID 19001420 DOI: 10.1074/jbc.M804632200  0.88
2008 Enoksson M, Salvesen GS. Proteolytic needles in the cellular haystack. Nature Chemical Biology. 4: 651-2. PMID 18936746 DOI: 10.1038/nchembio1108-651  0.88
2008 Drag M, Salvesen GS. DeSUMOylating enzymes--SENPs. Iubmb Life. 60: 734-42. PMID 18666185 DOI: 10.1002/iub.113  0.88
2008 Pop C, Salvesen GS, Scott FL. Caspase assays: identifying caspase activity and substrates in vitro and in vivo. Methods in Enzymology. 446: 351-67. PMID 18603133 DOI: 10.1016/S0076-6879(08)01621-2  0.88
2008 Drag M, Mikolajczyk J, Bekes M, Reyes-Turcu FE, Ellman JA, Wilkinson KD, Salvesen GS. Positional-scanning fluorigenic substrate libraries reveal unexpected specificity determinants of DUBs (deubiquitinating enzymes). The Biochemical Journal. 415: 367-75. PMID 18601651 DOI: 10.1042/BJ20080779  0.88
2008 Droga-Mazovec G, Bojic L, Petelin A, Ivanova S, Romih R, Repnik U, Salvesen GS, Stoka V, Turk V, Turk B. Cysteine cathepsins trigger caspase-dependent cell death through cleavage of bid and antiapoptotic Bcl-2 homologues. The Journal of Biological Chemistry. 283: 19140-50. PMID 18469004 DOI: 10.1074/jbc.M802513200  0.88
2008 Scott FL, Fuchs GJ, Boyd SE, Denault JB, Hawkins CJ, Dequiedt F, Salvesen GS. Caspase-8 cleaves histone deacetylase 7 and abolishes its transcription repressor function. The Journal of Biological Chemistry. 283: 19499-510. PMID 18458084 DOI: 10.1074/jbc.M800331200  0.88
2008 Salvesen GS, Riedl SJ. Caspase mechanisms. Advances in Experimental Medicine and Biology. 615: 13-23. PMID 18437889 DOI: 10.1007/978-1-4020-6554-5_2  0.88
2008 Snipas SJ, Drag M, Stennicke HR, Salvesen GS. Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC Cell Death and Differentiation. 15: 938-945. PMID 18309328 DOI: 10.1038/cdd.2008.23  0.88
2008 Eckelman BP, Drag M, Snipas SJ, Salvesen GS. The mechanism of peptide-binding specificity of IAP BIR domains. Cell Death and Differentiation. 15: 920-8. PMID 18239672 DOI: 10.1038/cdd.2008.6  0.88
2008 Denault JB, Salvesen GS. Apoptotic caspase activation and activity. Methods in Molecular Biology (Clifton, N.J.). 414: 191-220. PMID 18175821  0.88
2008 McStay GP, Salvesen GS, Green DR. Overlapping cleavage motif selectivity of caspases: Implications for analysis of apoptotic pathways Cell Death and Differentiation. 15: 322-331. PMID 17975551 DOI: 10.1038/sj.cdd.4402260  0.88
2008 Drag M, Mikolajczyk J, Krishnakumar IM, Huang Z, Salvesen GS. Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family. The Biochemical Journal. 409: 461-9. PMID 17916063 DOI: 10.1042/BJ20070940  0.88
2008 Enoksson M, Zhu W, Salvesen GS. Identification of protease substrates by mass spectrometry approaches-1 The Cancer Degradome: Proteases and Cancer Biology. 67-82. DOI: 10.1007/978-0-387-69057-5_5  0.88
2007 Denault JB, Drag M, Salvesen GS, Alves J, Heidt AB, Deveraux Q, Harris JL. Small molecules not direct activators of caspases. Nature Chemical Biology. 3: 519; author reply 52. PMID 17710090 DOI: 10.1038/nchembio0907-519  0.88
2007 Truscott M, Denault JB, Goulet B, Leduy L, Salvesen GS, Nepveu A. Carboxyl-terminal proteolytic processing of CUX1 by a caspase enables transcriptional activation in proliferating cells. The Journal of Biological Chemistry. 282: 30216-26. PMID 17681953 DOI: 10.1074/jbc.M702328200  0.88
2007 Wu YI, Munshi HG, Snipas SJ, Salvesen GS, Fridman R, Stack MS. Activation-coupled membrane-type 1 matrix metalloproteinase membrane trafficking. The Biochemical Journal. 407: 171-7. PMID 17650075 DOI: 10.1042/BJ20070552  0.88
2007 Timmer JC, Enoksson M, Wildfang E, Zhu W, Igarashi Y, Denault JB, Ma Y, Dummitt B, Chang YH, Mast AE, Eroshkin A, Smith JW, Tao WA, Salvesen GS. Profiling constitutive proteolytic events in vivo. The Biochemical Journal. 407: 41-8. PMID 17650073 DOI: 10.1042/BJ20070775  0.88
2007 Mikolajczyk J, Drag M, Békés M, Cao JT, Ronai Z, Salvesen GS. Small ubiquitin-related modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs. The Journal of Biological Chemistry. 282: 26217-24. PMID 17591783 DOI: 10.1074/jbc.M702444200  0.88
2007 Enoksson M, Li J, Ivancic MM, Timmer JC, Wildfang E, Eroshkin A, Salvesen GS, Tao WA. Identification of proteolytic cleavage sites by quantitative proteomics. Journal of Proteome Research. 6: 2850-8. PMID 17547438 DOI: 10.1021/pr0701052  0.88
2007 Salvesen GS, Riedl SJ. Caspase inhibition, specifically. Structure (London, England : 1993). 15: 513-4. PMID 17502096 DOI: 10.1016/j.str.2007.04.006  0.88
2007 Denault JB, Eckelman BP, Shin H, Pop C, Salvesen GS. Caspase 3 attenuates XIAP (X-linked inhibitor of apoptosis protein)-mediated inhibition of caspase 9. The Biochemical Journal. 405: 11-9. PMID 17437405 DOI: 10.1042/BJ20070288  0.88
2007 Riedl SJ, Salvesen GS. The apoptosome: signalling platform of cell death. Nature Reviews. Molecular Cell Biology. 8: 405-13. PMID 17377525 DOI: 10.1038/nrm2153  0.88
2007 Pop C, Fitzgerald P, Green DR, Salvesen GS. Role of proteolysis in caspase-8 activation and stabilization. Biochemistry. 46: 4398-407. PMID 17371051 DOI: 10.1021/bi602623b  0.88
2007 Timmer JC, Salvesen GS. Caspase substrates Cell Death and Differentiation. 14: 66-72. PMID 17082814 DOI: 10.1038/sj.cdd.4402059  0.88
2006 Dobó J, Swanson R, Salvesen GS, Olson ST, Gettins PG. Cytokine response modifier a inhibition of initiator caspases results in covalent complex formation and dissociation of the caspase tetramer. The Journal of Biological Chemistry. 281: 38781-90. PMID 17052983 DOI: 10.1074/jbc.M605151200  0.88
2006 Eckelman BP, Salvesen GS, Scott FL. Human inhibitor of apoptosis proteins: why XIAP is the black sheep of the family. Embo Reports. 7: 988-94. PMID 17016456 DOI: 10.1038/sj.embor.7400795  0.88
2006 Ekici OD, Li ZZ, Campbell AJ, James KE, Asgian JL, Mikolajczyk J, Salvesen GS, Ganesan R, Jelakovic S, Grütter MG, Powers JC. Design, synthesis, and evaluation of aza-peptide Michael acceptors as selective and potent inhibitors of caspases-2, -3, -6, -7, -8, -9, and -10. Journal of Medicinal Chemistry. 49: 5728-49. PMID 16970398 DOI: 10.1021/jm0601405  0.88
2006 Denault JB, Békés M, Scott FL, Sexton KM, Bogyo M, Salvesen GS. Engineered hybrid dimers: tracking the activation pathway of caspase-7. Molecular Cell. 23: 523-33. PMID 16916640 DOI: 10.1016/j.molcel.2006.06.020  0.88
2006 Berger AB, Witte MD, Denault JB, Sadaghiani AM, Sexton KM, Salvesen GS, Bogyo M. Identification of early intermediates of caspase activation using selective inhibitors and activity-based probes. Molecular Cell. 23: 509-21. PMID 16916639 DOI: 10.1016/j.molcel.2006.06.021  0.88
2006 Pop C, Timmer J, Sperandio S, Salvesen GS. The apoptosome activates caspase-9 by dimerization. Molecular Cell. 22: 269-75. PMID 16630894 DOI: 10.1016/j.molcel.2006.03.009  0.88
2006 Stennicke HR, Salvesen GS. Chemical ligation--an unusual paradigm in protease inhibition. Molecular Cell. 21: 727-8. PMID 16543139 DOI: 10.1016/j.molcel.2006.03.001  0.88
2006 Eckelman BP, Salvesen GS. The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases. The Journal of Biological Chemistry. 281: 3254-60. PMID 16339151 DOI: 10.1074/jbc.M510863200  0.88
2006 Salvesen GS, Murphy G, Nagase H. The trap hypothesis: α2M and protease inhibition Biochemist. 28: 46-48.  0.88
2005 Kato D, Boatright KM, Berger AB, Nazif T, Blum G, Ryan C, Chehade KA, Salvesen GS, Bogyo M. Activity-based probes that target diverse cysteine protease families. Nature Chemical Biology. 1: 33-8. PMID 16407991 DOI: 10.1038/nchembio707  0.88
2005 Pop C, Salvesen GS. The nematode death machine in 3D. Cell. 123: 192-3. PMID 16239138 DOI: 10.1016/j.cell.2005.10.010  0.88
2005 Simonovic M, Denault JB, Salvesen GS, Volz K, Gettins PG. Lack of involvement of strand s1'A of the viral serpin CrmA in anti-apoptotic or caspase-inhibitory functions. Archives of Biochemistry and Biophysics. 440: 1-9. PMID 15993378 DOI: 10.1016/  0.88
2005 Gregorc U, Dobersek A, Salvesen GS, Turk V, Turk B, Kopitar-Jerala N. A novel caspase-7 specific monoclonal antibody. Immunology Letters. 98: 167-9. PMID 15849872 DOI: 10.1016/j.imlet.2004.11.001  0.88
2005 Scott FL, Denault JB, Riedl SJ, Shin H, Renatus M, Salvesen GS. XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs. The Embo Journal. 24: 645-55. PMID 15650747 DOI: 10.1038/sj.emboj.7600544  0.88
2005 Bruckner S, Rhamouni S, Tautz L, Denault JB, Alonso A, Becattini B, Salvesen GS, Mustelin T. Yersinia phosphatase induces mitochondrially dependent apoptosis of T cells. The Journal of Biological Chemistry. 280: 10388-94. PMID 15632192 DOI: 10.1074/jbc.M408829200  0.88
2005 Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP. The Biochemical Journal. 385: 11-20. PMID 15485396 DOI: 10.1042/BJ20041108  0.88
2005 Shin H, Renatus M, Eckelman BP, Nunes VA, Sampaio CA, Salvesen GS. The BIR domain of IAP-like protein 2 is conformationally unstable: implications for caspase inhibition. The Biochemical Journal. 385: 1-10. PMID 15485395 DOI: 10.1042/BJ20041107  0.88
2005 Turk B, Turk D, Salvesen GS. Regulating cysteine protease activity: Essential role of protease inhibitors as guardians and regulators Medicinal Chemistry Reviews - Online. 2: 283-297. DOI: 10.2174/1381612023394124  0.88
2004 Snipas SJ, Wildfang E, Nazif T, Christensen L, Boatright KM, Bogyo M, Stennicke HR, Salvesen GS. Characteristics of the caspase-like catalytic domain of human paracaspase. Biological Chemistry. 385: 1093-8. PMID 15576331 DOI: 10.1515/BC.2004.142  0.88
2004 Fuentes-Prior P, Salvesen GS. The protein structures that shape caspase activity, specificity, activation and inhibition. The Biochemical Journal. 384: 201-32. PMID 15450003 DOI: 10.1042/BJ20041142  0.88
2004 Krajewska M, Rosenthal RE, Mikolajczyk J, Stennicke HR, Wiesenthal T, Mai J, Naito M, Salvesen GS, Reed JC, Fiskum G, Krajewski S. Early processing of Bid and caspase-6, -8, -10, -14 in the canine brain during cardiac arrest and resuscitation. Experimental Neurology. 189: 261-79. PMID 15380478 DOI: 10.1016/j.expneurol.2004.05.020  0.88
2004 Wilkinson JC, Wilkinson AS, Scott FL, Csomos RA, Salvesen GS, Duckettt CS. Neutralization of Smac/Diablo by inhibitors of apoptosis (IAPs): A caspase-independent mechanism for apoptotic inhibition Journal of Biological Chemistry. 279: 51082-51090. PMID 15371416 DOI: 10.1074/jbc.M408655200  0.88
2004 Mikolajczyk J, Scott FL, Krajewski S, Sutherlin DP, Salvesen GS. Activation and substrate specificity of caspase-14. Biochemistry. 43: 10560-9. PMID 15301553 DOI: 10.1021/bi0498048  0.88
2004 Dohi T, Okada K, Xia F, Wilford CE, Samuel T, Welsh K, Marusawa H, Zou H, Armstrong R, Matsuzawa S, Salvesen GS, Reed JC, Altieri DC. An IAP-IAP complex inhibits apoptosis. The Journal of Biological Chemistry. 279: 34087-90. PMID 15218035 DOI: 10.1074/jbc.C400236200  0.88
2004 Boatright KM, Deis C, Denault JB, Sutherlin DP, Salvesen GS. Activation of caspases-8 and -10 by FLIP(L). The Biochemical Journal. 382: 651-7. PMID 15209560 DOI: 10.1042/BJ20040809  0.88
2004 Salvesen GS, Abrams JM. Caspase activation - stepping on the gas or releasing the brakes? Lessons from humans and flies. Oncogene. 23: 2774-84. PMID 15077141 DOI: 10.1038/sj.onc.1207522  0.88
2004 Ekici OD, Götz MG, James KE, Li ZZ, Rukamp BJ, Asgian JL, Caffrey CR, Hansell E, Dvorák J, McKerrow JH, Potempa J, Travis J, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. Journal of Medicinal Chemistry. 47: 1889-92. PMID 15055989 DOI: 10.1021/jm049938j  0.88
2004 James KE, Asgian JL, Li ZZ, Ekici OD, Rubin JR, Mikolajczyk J, Salvesen GS, Powers JC. Design, synthesis, and evaluation of aza-peptide epoxides as selective and potent inhibitors of caspases-1, -3, -6, and -8. Journal of Medicinal Chemistry. 47: 1553-74. PMID 14998341 DOI: 10.1021/jm0305016  0.88
2004 Pedersen IM, Zapata JM, Samuel T, Scott FL, Salvesen GS, Honda T, Gribble GW, Suh N, Sporn MB, Kipps TJ, Reed JC. Retraction: The triterpenoid CDDO-Imidazolide induces apoptosis and enhances fludarabine-induced apoptosis of CLL B-cells. Blood. 104: 932. PMID 14739219 DOI: 10.1182/blood-2003-11-3774  0.88
2004 Wu YI, Munshi HG, Sen R, Snipas SJ, Salvesen GS, Fridman R, Stack MS. Glycosylation broadens the substrate profile of membrane type 1 matrix metalloproteinase. The Journal of Biological Chemistry. 279: 8278-89. PMID 14670950 DOI: 10.1074/jbc.M311870200  0.88
2004 Cirman T, Orešić K, Mazovec GD, Turk V, Reed JC, Myers RM, Salvesen GS, Turk B. Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins Journal of Biological Chemistry. 279: 3578-3587. PMID 14581476 DOI: 10.1074/jbc.M308347200  0.88
2003 Denault JB, Salvesen GS. Expression, purification, and characterization of caspases. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.13. PMID 18429241 DOI: 10.1002/0471140864.ps2113s30  0.88
2003 Boatright KM, Salvesen GS. Mechanisms of caspase activation. Current Opinion in Cell Biology. 15: 725-31. PMID 14644197 DOI: 10.1016/  0.88
2003 Boatright KM, Salvesen GS. Caspase activation. Biochemical Society Symposium. 233-42. PMID 14587296  0.88
2003 Ryan CA, Salvesen GS. Caspases and neuronal development Biological Chemistry. 384: 855-861. PMID 12887052 DOI: 10.1515/BC.2003.096  0.88
2003 Kashkar H, Haefs C, Shin H, Hamilton-Dutoit SJ, Salvesen GS, Kronke M, Jurgensmeier JM. XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells. The Journal of Experimental Medicine. 198: 341-7. PMID 12874265 DOI: 10.1084/jem.20021279  0.88
2003 Denault JB, Salvesen GS. Human Caspase-7 Activity and Regulation by Its N-terminal Peptide Journal of Biological Chemistry. 278: 34042-34050. PMID 12824163 DOI: 10.1074/jbc.M305110200  0.88
2003 Shin H, Okada K, Wilkinson JC, Solomon KM, Duckett CS, Reed JC, Salvesen GS. Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein Biochemical Journal. 373: 965-971. PMID 12747801 DOI: 10.1042/BJ20030583  0.88
2003 Salvesen GS, Scott FL. Serpins are getting hotter Structure. 11: 364-365. PMID 12679013 DOI: 10.1016/S0969-2126(03)00058-3  0.88
2003 Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, Salvesen GS. A unified model for apical caspase activation. Molecular Cell. 11: 529-41. PMID 12620239 DOI: 10.1016/S1097-2765(03)00051-0  0.88
2003 Mikolajczyk J, Boatright KM, Stennicke HR, Nazif T, Potempa J, Bogyo M, Salvesen GS. Sequential autolytic processing activates the zymogen of Arg-gingipain. The Journal of Biological Chemistry. 278: 10458-64. PMID 12533545 DOI: 10.1074/jbc.M210564200  0.88
2002 Denault JB, Salvesen GS. Caspases. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 21.8. PMID 18429233 DOI: 10.1002/0471140864.ps2108s26  0.88
2002 Denault JB, Salvesen GS. Caspases: Keys in the ignition of cell death Chemical Reviews. 102: 4489-4499. PMID 12475198 DOI: 10.1021/cr010183n  0.88
2002 Salvesen GS. Caspases and apoptosis Essays in Biochemistry. 38: 9-19. PMID 12463158  0.88
2002 Asgian JL, James KE, Li ZZ, Carter W, Barrett AJ, Mikolajczyk J, Salvesen GS, Powers JC. Aza-peptide epoxides: a new class of inhibitors selective for clan CD cysteine proteases. Journal of Medicinal Chemistry. 45: 4958-60. PMID 12408706 DOI: 10.1021/jm025581c  0.88
2002 Troy CM, Salvesen GS. Caspases on the brain. Journal of Neuroscience Research. 69: 145-50. PMID 12111795 DOI: 10.1002/jnr.10294  0.88
2002 Ryan CA, Stennicke HR, Nava VE, Burch JB, Hardwick JM, Salvesen GS. Inhibitor specificity of recombinant and endogenous caspase-9. The Biochemical Journal. 366: 595-601. PMID 12067274 DOI: 10.1042/BJ20020863  0.88
2002 Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nature Reviews. Molecular Cell Biology. 3: 401-10. PMID 12042762 DOI: 10.1038/nrm830  0.88
2002 Lu C, Fu W, Salvesen GS, Mattson MP. Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death. Neuromolecular Medicine. 1: 69-79. PMID 12025817 DOI: 10.1385/NMM:1:1:69  0.88
2002 Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, Bestvater F, Holloschi A, Knoch TA, Auerswald EA, Welsh K, Reed JC, Fritz H, Fuentes-Prior P, Spiess E, Salvesen GS, Machleidt W. Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members Journal of Biological Chemistry. 277: 27217-27226. PMID 12000759 DOI: 10.1074/jbc.M202945200  0.88
2002 Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA. Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 99: 3974-9. PMID 11904443 DOI: 10.1073/pnas.022036399  0.88
2002 Salvesen GS, Renatus M. Apoptosome: The seven-spoked death machine Developmental Cell. 2: 256-257. PMID 11879630 DOI: 10.1016/S1534-5807(02)00137-5  0.88
2002 Stennicke HR, Ryan CA, Salvesen GS. Reprieval from execution: The molecular basis of caspase inhibition Trends in Biochemical Sciences. 27: 94-101. PMID 11852247 DOI: 10.1016/S0968-0004(01)02045-X  0.88
2002 Salvesen GS. Caspases: Opening the boxes and interpreting the arrows Cell Death and Differentiation. 9: 3-5. PMID 11803369 DOI: 10.1038/sj.cdd.4400963  0.88
2001 Riedl SJ, Fuentes-Prior P, Renatus M, Kairies N, Krapp S, Huber R, Salvesen GS, Bode W. Structural basis for the activation of human procaspase-7 Proceedings of the National Academy of Sciences of the United States of America. 98: 14790-14795. PMID 11752425 DOI: 10.1073/pnas.221580098  0.88
2001 Renatus M, Stennicke HR, Scott FL, Liddington RC, Salvesen GS. Dimer formation drives the activation of the cell death protease caspase 9 Proceedings of the National Academy of Sciences of the United States of America. 98: 14250-14255. PMID 11734640 DOI: 10.1073/pnas.231465798  0.88
2001 Stefan JR, Renatus M, Snipas SJ, Salvesen GS. Mechanism-based inactivation of caspases by the apoptotic suppressor p35 Biochemistry. 40: 13274-13280. PMID 11683637 DOI: 10.1021/bi010574w  0.88
2001 Snipas SJ, Stennicke HR, Riedl S, Potempa J, Travis J, Barrett AJ, Salvesen GS. Inhibition of distant caspase homologues by natural caspase inhibitors. The Biochemical Journal. 357: 575-80. PMID 11439111 DOI: 10.1042/0264-6021:3570575  0.88
2001 Silverman GA, Bird PI, Carrell RW, Church FC, Coughlin PB, Gettins PG, Irving JA, Lomas DA, Luke CJ, Moyer RW, Pemberton PA, Remold-O'Donnell E, Salvesen GS, Travis J, Whisstock JC. The serpins are an expanding superfamily of structurally similar but functionally diverse proteins. Evolution, mechanism of inhibition, novel functions, and a revised nomenclature. The Journal of Biological Chemistry. 276: 33293-6. PMID 11435447 DOI: 10.1074/jbc.R100016200  0.88
2001 Riedl SJ, Renatus M, Schwarzenbacher R, Zhou Q, Sun C, Fesik SW, Liddington RC, Salvesen GS. Structural basis for the inhibition of caspase-3 by XIAP Cell. 104: 791-800. PMID 11257232  0.88
2001 Salvesen GS. A lysosomal protease enters the death scene Journal of Clinical Investigation. 107: 21-22. PMID 11134173  0.88
2001 Leo E, Deveraux QL, Buchholtz C, Welsh K, Matsuzawa SI, Stennicke HR, Salvesen GS, Reed JC. TRAF1 Is a Substrate of Caspases Activated during Tumor Necrosis Factor Receptor-α-induced Apoptosis Journal of Biological Chemistry. 276: 8087-8093. PMID 11098060 DOI: 10.1074/jbc.M009450200  0.88
2001 Stoka V, Turk B, Schendel SL, Kim TH, Cirman T, Snipas SJ, Ellerby LM, Bredesen D, Freeze H, Abrahamson M, Brömme D, Krajewski S, Reed JC, Yin XM, Turk V, ... Salvesen GS, et al. Lysosomal protease pathways to apoptosis: Cleavage of Bid, not pro-caspases, is the most likely route Journal of Biological Chemistry. 276: 3149-3157. PMID 11073962 DOI: 10.1074/jbc.M008944200  0.88
2001 Affar EB, Germain M, Winstall E, Vodenicharov M, Shah RG, Salvesen GS, Poirier GG. Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis. The Journal of Biological Chemistry. 276: 2935-42. PMID 11053413 DOI: 10.1074/jbc.M007269200  0.88
2000 Vucic D, Stennicke HR, Pisabarro MT, Salvesen GS, Dixit VM. ML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomas Current Biology. 10: 1359-1366. PMID 11084335 DOI: 10.1016/S0960-9822(00)00781-8  0.88
2000 Stennicke HR, Renatus M, Meldal M, Salvesen GS. Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8 Biochemical Journal. 350: 563-568. PMID 10947972 DOI: 10.1042/0264-6021:3500563  0.88
2000 Zhou Q, Salvesen GS. Viral caspase inhibitors CrmA and p35 Methods in Enzymology. 322: 143-154. PMID 10914011  0.88
2000 Renatus M, Zhou Q, Stennicke HR, Snipas SJ, Turk D, Bankston LA, Liddington RC, Salvesen GS. Crystal structure of the apoptotic suppressor CrmA in its cleaved form Structure. 8: 789-797. PMID 10903953 DOI: 10.1016/S0969-2126(00)00165-9  0.88
2000 Lu DC, Rabizadeh S, Chandra S, Shayya RF, Ellerby LM, Ye X, Salvesen GS, Koo EH, Bredesen DE. A second cytotoxic proteolytic peptide derived from amyloid beta-protein precursor. Nature Medicine. 6: 397-404. PMID 10742146 DOI: 10.1038/74656  0.88
2000 Stennicke HR, Salvesen GS. Caspases - Controlling intracellular signals by protease zymogen activation Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1477: 299-306. PMID 10708865 DOI: 10.1016/S0167-4838(99)00281-2  0.88
2000 Huang Q, Deveraux QL, Maeda S, Salvesen GS, Stennicke HR, Hammock BD, Reed JC. Evolutionary conservation of apoptosis mechanisms: lepidopteran and baculoviral inhibitor of apoptosis proteins are inhibitors of mammalian caspase-9. Proceedings of the National Academy of Sciences of the United States of America. 97: 1427-32. PMID 10677478 DOI: 10.1073/pnas.97.4.1427  0.88
1999 Deveraux QL, Stennicke HR, Salvesen GS, Reed JC. Endogenous inhibitors of caspases Journal of Clinical Immunology. 19: 388-398. PMID 10634212  0.88
1999 Stennicke HR, Salvesen GS. Catalytic properties of the caspases Cell Death and Differentiation. 6: 1054-1059. PMID 10578173  0.88
1999 Salvesen GS. Caspase 8: Igniting the death machine Structure. 7. PMID 10545333 DOI: 10.1016/S0969-2126(00)80048-9  0.88
1999 Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases Embo Journal. 18: 5242-5251. PMID 10508158 DOI: 10.1093/emboj/18.19.5242  0.88
1999 Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, Poirier GG. Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of caspase-7. The Journal of Biological Chemistry. 274: 28379-84. PMID 10497198 DOI: 10.1074/jbc.274.40.28379  0.88
1999 Wolf BB, Goldstein JC, Stennicke HR, Beere H, Amarante-Mendes GP, Salvesen GS, Green DR. Calpain functions in a caspase-independent manner to promote apoptosis-like events during platelet activation. Blood. 94: 1683-92. PMID 10477693  0.88
1999 Krajewski S, Krajewska M, Ellerby LM, Welsh K, Xie Z, Deveraux QL, Salvesen GS, Bredesen DE, Rosenthal RE, Fiskum G, Reed JC. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia Proceedings of the National Academy of Sciences of the United States of America. 96: 5752-5757. PMID 10318956 DOI: 10.1073/pnas.96.10.5752  0.88
1999 Stennicke HR, Salvesen GS. Caspases: Preparation and characterization Methods: a Companion to Methods in Enzymology. 17: 313-319. PMID 10196102 DOI: 10.1006/meth.1999.0745  0.88
1999 Salvesen GS. Programmed cell death and the caspases Apmis. 107: 73-79. PMID 10190282  0.88
1999 Chou JJ, Li H, Salvesen GS, Yuan J, Wagner G. Solution structure of BID, an intracellular amplifier of apoptotic signaling. Cell. 96: 615-24. PMID 10089877  0.88
1999 Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity. The Journal of Biological Chemistry. 274: 8730-6. PMID 10085113 DOI: 10.1074/jbc.274.13.8730  0.88
1999 Stennicke HR, Deveraux QL, Humke EW, Reed JC, Dixit VM, Salvesen GS. Caspase-9 can be activated without proteolytic processing. The Journal of Biological Chemistry. 274: 8359-62. PMID 10085063 DOI: 10.1074/jbc.274.13.8359  0.88
1999 Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity. Journal of Neurochemistry. 72: 185-95. PMID 9886069 DOI: 10.1046/j.1471-4159.1999.0720185.x  0.88
1999 Salvesen GS, Dixit VM. Caspase activation: The induced-proximity model Proceedings of the National Academy of Sciences of the United States of America. 96: 10964-10967. DOI: 10.1073/pnas.96.20.10964  0.88
1998 Amarante-Mendes GP, Finucane DM, Martin SJ, Cotter TG, Salvesen GS, Green DR. Anti-apoptotic oncogenes prevent caspase-dependent and independent commitment for cell death Cell Death and Differentiation. 5: 298-306. PMID 10200475  0.88
1998 Miyashita T, Nagao K, Krajewski S, Salvesen GS, Reed JC, Inoue T, Yamada M. Investigation of glucocorticoid-induced apoptotic pathway: Processing of caspase-6 but not caspase-3 Cell Death and Differentiation. 5: 1034-1041. PMID 9894610  0.88
1998 Yang X, Stennicke HR, Wang B, Green DR, Jänicke RU, Srinivasan A, Seth P, Salvesen GS, Froelich CJ. Granzyme B mimics apical caspases: Description of a unified pathway for trans-activation of executioner caspase-3 and -7 Journal of Biological Chemistry. 273: 34278-34283. PMID 9852092 DOI: 10.1074/jbc.273.51.34278  0.88
1998 Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC. Regulation of cell death protease caspase-9 by phosphorylation Science. 282: 1318-1321. PMID 9812896 DOI: 10.1126/science.282.5392.1318  0.88
1998 Mehlen P, Rabizadeh S, Snipas SJ, Assa-Munt N, Salvesen GS, Bredesen DE. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis Nature. 395: 801-804. PMID 9796814 DOI: 10.1038/27441  0.88
1998 Stennicke HR, Jürgensmeier JM, Shin H, Deveraux Q, Wolf BB, Yang X, Zhou Q, Ellerby HM, Ellerby LM, Bredesen D, Green DR, Reed JC, Froelich CJ, Salvesen GS. Pro-caspase-3 is a major physiologic target of caspase-8. The Journal of Biological Chemistry. 273: 27084-90. PMID 9765224 DOI: 10.1074/jbc.273.42.27084  0.88
1998 Stennicke HR, Salvesen GS. Properties of the caspases Biochimica Et Biophysica Acta - Protein Structure and Molecular Enzymology. 1387: 17-31. PMID 9748481 DOI: 10.1016/S0167-4838(98)00133-2  0.88
1998 Zhou Q, Krebs JF, Snipas SJ, Price A, Alnemri ES, Tomaselli KJ, Salvesen GS. Interaction of the baculovirus anti-apoptotic protein p35 with caspases. Specificity, kinetics, and characterization of the caspase/p35 complex Biochemistry. 37: 10757-10765. PMID 9692966 DOI: 10.1021/bi980893w  0.88
1998 Deveraux QL, Roy N, Stennicke HR, Van Arsdale T, Zhou Q, Srinivasula SM, Alnemri ES, Salvesen GS, Reed JC. IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases Embo Journal. 17: 2215-2223. PMID 9545235 DOI: 10.1093/emboj/17.8.2215  0.88
1998 Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, et al. Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract. The Journal of Biological Chemistry. 273: 9158-67. PMID 9535906 DOI: 10.1074/jbc.273.15.9158  0.88
1998 Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS, Reed JC. A single BIR domain of XIAP sufficient for inhibiting caspases. The Journal of Biological Chemistry. 273: 7787-90. PMID 9525868 DOI: 10.1074/jbc.273.14.7787  0.88
1998 Muzio M, Stockwell BR, Stennicke HR, Salvesen GS, Dixit VM. An induced proximity model for caspase-8 activation. The Journal of Biological Chemistry. 273: 2926-30. PMID 9446604 DOI: 10.1074/jbc.273.5.2926  0.88
1997 Salvesen GS, Dixit VM. Caspases: Intracellular signaling by proteolysis Cell. 91: 443-446. PMID 9390553 DOI: 10.1016/S0092-8674(00)80430-4  0.88
1997 Perry DK, Smyth MJ, Stennicke HR, Salvesen GS, Duriez P, Poirier GG, Hannun YA. Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. The Journal of Biological Chemistry. 272: 18530-3. PMID 9228015 DOI: 10.1074/jbc.272.30.18530  0.88
1997 Zhou Q, Snipas S, Ortht K, Muzio M, Dixit VM, Salvesen GS. Target protease specificity of the viral serpin CrmA. Analysis of five cascapses Journal of Biological Chemistry. 272: 7797-7800. PMID 9065443 DOI: 10.1074/jbc.272.12.7797  0.88
1997 Muzio M, Salvesen GS, Dixit VM. FLICE induced apoptosis in a cell-free system. Cleavage of caspase zymogens Journal of Biological Chemistry. 272: 2952-2956. PMID 9006941 DOI: 10.1074/jbc.272.5.2952  0.88
1996 Orth K, O'Rourke K, Salvesen GS, Dixit VM. Molecular ordering of apoptotic mammalian CED-3/ICE-like proteases Journal of Biological Chemistry. 271: 20977-20980. PMID 8702858 DOI: 10.1074/jbc.271.35.20977  0.88
1996 Quan LT, Tewari M, O'Rourke K, Dixit V, Snipas SJ, Poirier GG, Ray C, Pickup DJ, Salvesen GS. Proteolytic activation of the cell death protease Yama/CPP32 by granzyme B. Proceedings of the National Academy of Sciences of the United States of America. 93: 1972-6. PMID 8700869 DOI: 10.1073/pnas.93.5.1972  0.36
1995 Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen GS, Dixit VM. Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell. 81: 801-9. PMID 7774019 DOI: 10.1016/0092-8674(95)90541-3  0.88
1995 Quan LT, Caputo A, Bleackley RC, Pickup DJ, Salvesen GS. Granzyme B is inhibited by the cowpox virus serpin cytokine response modifier A. The Journal of Biological Chemistry. 270: 10377-9. PMID 7737968 DOI: 10.1074/jbc.270.18.10377  0.88
1993 Strittmatter WJ, Weisgraber KH, Huang DY, Dong LM, Salvesen GS, Pericak-Vance M, Schmechel D, Saunders AM, Goldgaber D, Roses AD. Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease. Proceedings of the National Academy of Sciences of the United States of America. 90: 8098-102. PMID 8367470 DOI: 10.1073/pnas.90.17.8098  0.88
1989 Roche PA, Salvesen GS, Pizzo SV. Symmetry of the inhibitory unit of human alpha 2-macroglobulin. Biochemistry. 27: 7876-81. PMID 2462911 DOI: 10.1021/bi00420a044  0.68
1980 Salvesen GS, Barrett AJ. Covalent binding of proteinases in their reaction with alpha 2-macroglobulin Biochemical Journal. 187: 695-701. PMID 6204637 DOI: 10.1042/bj1870695  0.88
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