Douglas F. Covey - Publications

Washington University, Saint Louis, St. Louis, MO 
Biochemistry, Organic Chemistry, Pharmacology

194 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Qian M, Engler-Chiurazzi EB, Lewis SE, Rath NP, Simpkins JW, Covey DF. Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens. Organic & Biomolecular Chemistry. PMID 27714297 DOI: 10.1039/C6Ob01726F  1
2015 Horváth G, Bencsura Á, Simon Á, Tochtrop GP, DeKoster GT, Covey DF, Cistola DP, Toke O. Structural determinants of ligand binding in the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR. The Febs Journal. PMID 26613247 DOI: 10.1111/Febs.13610  0.8
2015 Mydock-McGrane L, Rath NP, Covey DF. Correction to Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol. The Journal of Organic Chemistry. 80: 6000. PMID 25988770 DOI: 10.1021/Acs.Joc.5B01073  0.44
2014 Krause MR, Wang M, Mydock-McGrane L, Covey DF, Tejada E, Almeida PF, Regen SL. Eliminating the roughness in cholesterol's β-face: does it matter? Langmuir : the Acs Journal of Surfaces and Colloids. 30: 12114-8. PMID 25290635 DOI: 10.1021/La503075E  1
2014 Bandari S, Chakraborty H, Covey DF, Chattopadhyay A. Membrane dipole potential is sensitive to cholesterol stereospecificity: implications for receptor function. Chemistry and Physics of Lipids. 184: 25-9. PMID 25219773 DOI: 10.1016/J.Chemphyslip.2014.09.001  1
2014 Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Neuropharmacology. 85: 232-42. PMID 24878244 DOI: 10.1016/J.Neuropharm.2014.05.027  1
2014 Mydock-McGrane L, Rath NP, Covey DF. Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol. The Journal of Organic Chemistry. 79: 5636-43. PMID 24823889 DOI: 10.1021/Jo500813N  1
2014 Eaton MM, Lim YB, Covey DF, Akk G. Modulation of the human ρ1 GABAA receptor by inhibitory steroids. Psychopharmacology. 231: 3467-78. PMID 24317445 DOI: 10.1007/S00213-013-3379-Z  1
2013 Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife. 2: e01340. PMID 24171105 DOI: 10.7554/Elife.01340  1
2013 Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, et al. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 62: 3828-38. PMID 23835327 DOI: 10.2337/Db13-0813  1
2013 Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity. 38: 106-18. PMID 23273843 DOI: 10.1016/J.Immuni.2012.11.004  1
2013 Zorumski CF, Paul SM, Izumi Y, Covey DF, Mennerick S. Neurosteroids, stress and depression: potential therapeutic opportunities. Neuroscience and Biobehavioral Reviews. 37: 109-22. PMID 23085210 DOI: 10.1016/J.Neubiorev.2012.10.005  1
2013 Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Elife. 2013. DOI: 10.7554/eLife.01340.001  1
2012 Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular Pharmacology. 82: 408-19. PMID 22648971 DOI: 10.1124/Mol.112.078410  1
2012 Chen ZW, Chen LH, Akentieva N, Lichti CF, Darbandi R, Hastings R, Covey DF, Reichert DE, Townsend RR, Evers AS. A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis. 33: 666-74. PMID 22451060 DOI: 10.1002/Elps.201100434  1
2012 Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nature Chemical Biology. 8: 211-20. PMID 22231273 DOI: 10.1038/Nchembio.765  1
2012 Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S. Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. British Journal of Pharmacology. 165: 2228-43. PMID 21950777 DOI: 10.1111/J.1476-5381.2011.01690.X  1
2011 Stastna E, Rath NP, Covey DF. The use of symmetry in enantioselective synthesis: four pairs of chrysene enantiomers prepared from 19-nortestosterone. Organic & Biomolecular Chemistry. 9: 4685-94. PMID 21541379 DOI: 10.1039/C1Ob05385J  0.44
2011 Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity. Journal of Medicinal Chemistry. 54: 3926-34. PMID 21504158 DOI: 10.1021/Jm2002487  0.44
2010 Bandyopadhyaya AK, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorganic & Medicinal Chemistry Letters. 20: 6680-4. PMID 20875742 DOI: 10.1016/J.Bmcl.2010.09.008  0.44
2010 Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH. Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current Neuropharmacology. 8: 18-25. PMID 20808543 DOI: 10.2174/157015910790909458  1
2010 Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A. T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology. 59: 380-7. PMID 20547167 DOI: 10.1016/J.Neuropharm.2010.05.012  1
2010 Chisari M, Eisenman LN, Covey DF, Mennerick S, Zorumski CF. The sticky issue of neurosteroids and GABA(A) receptors. Trends in Neurosciences. 33: 299-306. PMID 20409596 DOI: 10.1016/J.Tins.2010.03.005  1
2010 Minogue S, Chu KM, Westover EJ, Covey DF, Hsuan JJ, Waugh MG. Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. Journal of Lipid Research. 51: 2314-24. PMID 20388919 DOI: 10.1194/Jlr.M005751  0.92
2010 Evers AS, Chen ZW, Manion BD, Han M, Jiang X, Darbandi-Tonkabon R, Kable T, Bracamontes J, Zorumski CF, Mennerick S, Steinbach JH, Covey DF. A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. The Journal of Pharmacology and Experimental Therapeutics. 333: 404-13. PMID 20124410 DOI: 10.1124/Jpet.109.164079  1
2010 Robinson CH, Covey DF. Biological formation and reactions The Chemistry of Ketenes, Allenes and Related Compounds: Part 1. 1: 451-485. DOI: 10.1002/9780470771600.ch13  1
2009 Li P, Bandyopadhyaya AK, Covey DF, Steinbach JH, Akk G. Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation. British Journal of Pharmacology. 158: 1322-9. PMID 19702782 DOI: 10.1111/J.1476-5381.2009.00390.X  1
2009 Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes. 58: 2656-65. PMID 19651818 DOI: 10.2337/Db08-1763  1
2009 Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S. Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Molecular Pharmacology. 76: 754-65. PMID 19596835 DOI: 10.1124/Mol.109.057687  1
2009 Jevtovic-Todorovic V, Covey DF, Todorovic SM. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology. 34: S178-85. PMID 19577375 DOI: 10.1016/J.Psyneuen.2009.06.001  1
2009 Chisari M, Eisenman LN, Krishnan K, Bandyopadhyaya AK, Wang C, Taylor A, Benz A, Covey DF, Zorumski CF, Mennerick S. The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. Journal of Neurophysiology. 102: 1254-64. PMID 19553485 DOI: 10.1152/Jn.00346.2009  1
2009 Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology. 34: S59-66. PMID 19541427 DOI: 10.1016/J.Psyneuen.2009.05.020  1
2009 Eisenman LN, Shu HJ, Wang C, Aizenman E, Covey DF, Zorumski CF, Mennerick S. NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue. The Journal of Physiology. 587: 2937-47. PMID 19403611 DOI: 10.1113/Jphysiol.2009.172700  1
2009 Jin X, Covey DF, Steinbach JH. Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue. The Journal of Physiology. 587: 981-97. PMID 19124545 DOI: 10.1113/Jphysiol.2008.159343  1
2009 Covey DF. ent-Steroids: novel tools for studies of signaling pathways. Steroids. 74: 577-85. PMID 19103212 DOI: 10.1016/j.steroids.2008.11.019  1
2009 Katona BW, Anant S, Covey DF, Stenson WF. Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. The Journal of Biological Chemistry. 284: 3354-64. PMID 19054763 DOI: 10.1074/Jbc.M805804200  1
2009 Yi KD, Covey DF, Simpkins JW. Mechanism of okadaic acid-induced neuronal death and the effect of estrogens. Journal of Neurochemistry. 108: 732-40. PMID 19054278 DOI: 10.1111/J.1471-4159.2008.05805.X  1
2009 Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. The Journal of Biological Chemistry. 284: 1755-64. PMID 18996837 DOI: 10.1074/Jbc.M807210200  1
2009 Zampieri S, Mellon SH, Butters TD, Nevyjel M, Covey DF, Bembi B, Dardis A. Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. Journal of Cellular and Molecular Medicine. 13: 3786-96. PMID 18774957 DOI: 10.1111/J.1582-4934.2008.00493.X  1
2008 Komarapuri S, Krishnan K, Covey DF. Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone. Journal of Labelled Compounds & Radiopharmaceuticals. 51: 430-434. PMID 19122784 DOI: 10.1002/Jlcr.1558  1
2008 Akk G, Li P, Bracamontes J, Reichert DE, Covey DF, Steinbach JH. Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular Pharmacology. 74: 614-27. PMID 18544665 DOI: 10.1124/Mol.108.048520  1
2008 Mennerick S, Lamberta M, Shu HJ, Hogins J, Wang C, Covey DF, Eisenman LN, Zorumski CF. Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors. Biophysical Journal. 95: 176-85. PMID 18339741 DOI: 10.1529/Biophysj.107.124768  1
2008 Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. Journal of Medicinal Chemistry. 51: 1309-18. PMID 18275132 DOI: 10.1021/Jm701128R  1
2008 Alakoskela JM, Sabatini K, Jiang X, Laitala V, Covey DF, Kinnunen PK. Enantiospecific interactions between cholesterol and phospholipids. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 830-6. PMID 18171092 DOI: 10.1021/La702909Q  1
2008 Yi KD, Cai ZY, Covey DF, Simpkins JW. Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. The Journal of Pharmacology and Experimental Therapeutics. 324: 1188-95. PMID 18089844 DOI: 10.1124/Jpet.107.132308  1
2008 Katona BW, Krishnan K, Cai ZY, Manion BD, Benz A, Taylor A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. European Journal of Medicinal Chemistry. 43: 107-13. PMID 17434649 DOI: 10.1016/J.Ejmech.2007.02.017  1
2007 Wang C, Rath NP, Covey DF. Neurosteroid Analogues. 13. Synthetic methods for the preparation of 2beta-hydroxygonane derivatives as structural mimics of ent-3alpha-hydroxysteroid modulators of GABA(A) receptors. Tetrahedron. 63: 7977-7984. PMID 18698337 DOI: 10.1016/J.Tet.2007.05.068  1
2007 Joksovic PM, Covey DF, Todorovic SM. Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid. Annals of the New York Academy of Sciences. 1122: 83-94. PMID 18077566 DOI: 10.1196/Annals.1403.006  1
2007 Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF. Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. Journal of Medicinal Chemistry. 50: 6048-58. PMID 17963371 DOI: 10.1021/Jm0707931  1
2007 Katona BW, Rath NP, Anant S, Stenson WF, Covey DF. Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines. The Journal of Organic Chemistry. 72: 9298-307. PMID 17958446 DOI: 10.1021/Jo701559Q  1
2007 Izumi Y, Murayama K, Tokuda K, Krishnan K, Covey DF, Zorumski CF. GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. The European Journal of Neuroscience. 26: 1881-8. PMID 17883414 DOI: 10.1111/J.1460-9568.2007.05809.X  1
2007 Li P, Shu HJ, Wang C, Mennerick S, Zorumski CF, Covey DF, Steinbach JH, Akk G. Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of Physiology. 584: 789-800. PMID 17761771 DOI: 10.1113/Jphysiol.2007.142794  1
2007 Twede V, Tartaglia AL, Covey DF, Bamber BA. The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Molecular Pharmacology. 72: 1322-9. PMID 17715402 DOI: 10.1124/Mol.107.034058  1
2007 Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A. Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol. European Journal of Pharmacology. 572: 94-101. PMID 17658511 DOI: 10.1016/J.Ejphar.2007.06.028  1
2007 Li W, Jin X, Covey DF, Steinbach JH. Neuroactive steroids and human recombinant rho1 GABAC receptors. The Journal of Pharmacology and Experimental Therapeutics. 323: 236-47. PMID 17636008 DOI: 10.1124/Jpet.107.127365  1
2007 Jastrzebska I, Scaglione JB, Dekoster GT, Rath NP, Covey DF. Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems. The Journal of Organic Chemistry. 72: 4837-43. PMID 17530900 DOI: 10.1021/Jo070530E  1
2007 Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & Therapeutics. 116: 35-57. PMID 17524487 DOI: 10.1016/J.Pharmthera.2007.03.004  1
2007 Bordet T, Buisson B, Michaud M, Drouot C, Galéa P, Delaage P, Akentieva NP, Evers AS, Covey DF, Ostuni MA, Lacapère JJ, Massaad C, Schumacher M, Steidl EM, Maux D, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. The Journal of Pharmacology and Experimental Therapeutics. 322: 709-20. PMID 17496168 DOI: 10.1124/Jpet.107.123000  1
2007 Li P, Bracamontes J, Katona BW, Covey DF, Steinbach JH, Akk G. Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular Pharmacology. 71: 1582-90. PMID 17341652 DOI: 10.1124/Mol.106.033407  1
2007 Eisenman LN, Shu HJ, Akk G, Wang C, Manion BD, Kress GJ, Evers AS, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature Neuroscience. 10: 523-30. PMID 17322875 DOI: 10.1038/Nn1862  1
2007 Cai ZY, Covey DF. A facile total synthesis of ent-17beta-estradiol and structurally related analogues. Steroids. 72: 351-9. PMID 17257636 DOI: 10.1016/J.Steroids.2006.12.007  1
2007 Shu HJ, Zeng CM, Wang C, Covey DF, Zorumski CF, Mennerick S. Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions. British Journal of Pharmacology. 150: 164-75. PMID 17160009 DOI: 10.1038/sj.bjp.0706973  1
2007 Alakoskela JM, Covey DF, Kinnunen PK. Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers. Biochimica Et Biophysica Acta. 1768: 131-45. PMID 16945324 DOI: 10.1016/J.Bbamem.2006.07.011  1
2006 Wang C, Rath NP, Covey DF. Abnormal Beckmann fragmentation/ring closing metathesis route for preparation of 18-nor-Delta-androgens and their 18-nor-13,17-epoxide derivatives. Tetrahedron Letters. 47: 7837-7839. PMID 17440602 DOI: 10.1016/J.Tetlet.2006.09.027  1
2006 Lancaster RW, Karamertzanis PG, Hulme AT, Tocher DA, Covey DF, Price SL. Racemic progesterone: predicted in silico and produced in the solid state. Chemical Communications (Cambridge, England). 4921-3. PMID 17136247 DOI: 10.1039/B611599C  1
2006 Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 13807-12. PMID 16940355 DOI: 10.1073/Pnas.0606218103  1
2006 Westover EJ, Lin X, Riehl TE, Ma L, Stenson WF, Covey DF, Ostlund RE. Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Journal of Lipid Research. 47: 2374-81. PMID 16936324 DOI: 10.1194/Jlr.M600165-Jlr200  1
2006 VanLandingham JW, Cutler SM, Virmani S, Hoffman SW, Covey DF, Krishnan K, Hammes SR, Jamnongjit M, Stein DG. The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury. Neuropharmacology. 51: 1078-85. PMID 16926035 DOI: 10.1016/J.Neuropharm.2006.07.015  1
2006 Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. The Journal of Biological Chemistry. 281: 27816-26. PMID 16857673 DOI: 10.1074/Jbc.M603781200  1
2006 Scaglione JB, Manion BD, Benz A, Taylor A, DeKoster GT, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. Journal of Medicinal Chemistry. 49: 4595-605. PMID 16854065 DOI: 10.1021/Jm0602920  1
2006 Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain. 125: 53-64. PMID 16782275 DOI: 10.1016/J.Pain.2006.04.024  1
2006 Wang X, Dykens JA, Perez E, Liu R, Yang S, Covey DF, Simpkins JW. Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Molecular Pharmacology. 70: 395-404. PMID 16614138 DOI: 10.1124/Mol.106.022384  1
2006 Li P, Covey DF, Steinbach JH, Akk G. Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Molecular Pharmacology. 69: 2015-26. PMID 16554408 DOI: 10.1124/Mol.106.022590  1
2006 Li W, Covey DF, Alakoskela JM, Kinnunen PK, Steinbach JH. Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action. Molecular Pharmacology. 69: 1779-82. PMID 16527905 DOI: 10.1124/Mol.106.022863  1
2006 Westover EJ, Covey DF. Synthesis of ent-25-hydroxycholesterol. Steroids. 71: 484-8. PMID 16519912 DOI: 10.1016/J.Steroids.2006.01.007  1
2006 Covey DF. Ent-steroids chemistry and biology Polish Journal of Chemistry. 80: 511-522.  1
2005 Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S. Neurosteroid access to the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11605-13. PMID 16354918 DOI: 10.1523/Jneurosci.4173-05.2005  1
2005 Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 117: 326-39. PMID 16150542 DOI: 10.1016/J.Pain.2005.06.019  1
2005 Cenedella RJ, Sexton PS, Krishnan K, Covey DF. Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis. Lipids. 40: 635-40. PMID 16149744 DOI: 10.1007/S11745-005-1426-9  1
2005 Liu J, Chang CC, Westover EJ, Covey DF, Chang TY. Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. The Biochemical Journal. 391: 389-97. PMID 15992359 DOI: 10.1042/Bj20050428  1
2005 O'Dell LE, Purdy RH, Covey DF, Richardson HN, Roberto M, Koob GF. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacology, Biochemistry, and Behavior. 81: 543-50. PMID 15950269 DOI: 10.1016/J.Pbb.2005.03.020  1
2005 Zeng CM, Manion BD, Benz A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 48: 3051-9. PMID 15828844 DOI: 10.1021/Jm049027+  1
2005 Kumar DM, Perez E, Cai ZY, Aoun P, Brun-Zinkernagel AM, Covey DF, Simpkins JW, Agarwal N. Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity. Free Radical Biology & Medicine. 38: 1152-63. PMID 15808412 DOI: 10.1016/J.Freeradbiomed.2004.12.007  1
2005 Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain. 114: 429-43. PMID 15777868 DOI: 10.1016/J.Pain.2005.01.009  1
2005 Perez E, Liu R, Yang SH, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Research. 1038: 216-22. PMID 15757637 DOI: 10.1016/J.Brainres.2005.01.026  1
2005 Scaglione JB, Rath NP, Covey DF. First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes. The Journal of Organic Chemistry. 70: 1089-92. PMID 15675880 DOI: 10.1021/Jo048561M  1
2005 Evason K, Huang C, Yamben I, Covey DF, Kornfeld K. Anticonvulsant medications extend worm life-span. Science (New York, N.Y.). 307: 258-62. PMID 15653505 DOI: 10.1126/Science.1105299  1
2005 Todorovic SM, Covey DF, Zorumski CF, Jevtovic-Todorovic V. Neuroactive steroids as targets for development of novel pain therapies Current Medicinal Chemistry - Central Nervous System Agents. 5: 157-164. DOI: 10.2174/1568015054022407  1
2005 Cegelski L, Rice CV, O'Connor RD, Caruano AL, Tochtrop GP, Cai ZY, Covey DF, Schaefer J. Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR Drug Development Research. 66: 93-102. DOI: 10.1002/Ddr.20048  1
2005 Perez E, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of estratriene analogs: Structure-activity relationships and molecular optimization Drug Development Research. 66: 78-92. DOI: 10.1002/Ddr.20047  1
2004 Westover EJ, Covey DF. The enantiomer of cholesterol. The Journal of Membrane Biology. 202: 61-72. PMID 15702370 DOI: 10.1007/S00232-004-0714-7  1
2004 Dykens JA, Carroll AK, Wiley S, Covey DF, Cai ZY, Zhao L, Wen R. Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog. Biochemical Pharmacology. 68: 1971-84. PMID 15476668 DOI: 10.1016/J.Bcp.2004.06.042  1
2004 Simpkins JW, Yang SH, Liu R, Perez E, Cai ZY, Covey DF, Green PS. Estrogen-like compounds for ischemic neuroprotection. Stroke; a Journal of Cerebral Circulation. 35: 2648-51. PMID 15472107 DOI: 10.1161/01.Str.0000143734.59507.88  1
2004 Tochtrop GP, DeKoster GT, Covey DF, Cistola DP. A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. Journal of the American Chemical Society. 126: 11024-9. PMID 15339188 DOI: 10.1021/Ja047589C  1
2004 Shu HJ, Eisenman LN, Jinadasa D, Covey DF, Zorumski CF, Mennerick S. Slow actions of neuroactive steroids at GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6667-75. PMID 15282269 DOI: 10.1523/Jneurosci.1399-04.2004  1
2004 Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Molecular Pharmacology. 66: 1223-35. PMID 15280444 DOI: 10.1124/Mol.104.002402  1
2004 Li Y, Ge M, Ciani L, Kuriakose G, Westover EJ, Dura M, Covey DF, Freed JH, Maxfield FR, Lytton J, Tabas I. Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. The Journal of Biological Chemistry. 279: 37030-9. PMID 15215242 DOI: 10.1074/Jbc.M405195200  1
2004 Akk G, Bracamontes JR, Covey DF, Evers A, Dao T, Steinbach JH. Neuroactive steroids have multiple actions to potentiate GABAA receptors. The Journal of Physiology. 558: 59-74. PMID 15146041 DOI: 10.1113/Jphysiol.2004.066571  1
2004 Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF. Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Molecular Pharmacology. 65: 1191-7. PMID 15102947 DOI: 10.1124/Mol.65.5.1191  1
2004 Das P, Bell-Horner CL, Huang RQ, Raut A, Gonzales EB, Chen ZL, Covey DF, Dillon GH. Inhibition of type A GABA receptors by L-type calcium channel blockers. Neuroscience. 124: 195-206. PMID 14960351 DOI: 10.1016/J.Neuroscience.2003.12.005  1
2004 Gonzales EB, Bell-Horner CL, de la Cruz MA, Ferrendelli JA, Covey DF, Dillon GH. Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function. The Journal of Pharmacology and Experimental Therapeutics. 309: 677-83. PMID 14742738 DOI: 10.1124/Jpet.103.063008  1
2004 Darbandi-Tonkabon R, Manion BD, Hastings WR, Craigen WJ, Akk G, Bracamontes JR, He Y, Sheiko TV, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 308: 502-11. PMID 14593090 DOI: 10.1124/Jpet.103.058123  1
2003 Jiang X, Manion BD, Benz A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 46: 5334-48. PMID 14640542 DOI: 10.1021/Jm030302M  1
2003 Zitzer A, Westover EJ, Covey DF, Palmer M. Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol. Febs Letters. 553: 229-31. PMID 14572629 DOI: 10.1016/S0014-5793(03)01023-8  1
2003 Westover EJ, Covey DF, Brockman HL, Brown RE, Pike LJ. Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. The Journal of Biological Chemistry. 278: 51125-33. PMID 14530278 DOI: 10.1074/Jbc.M304332200  1
2003 Tochtrop GP, Bruns JL, Tang C, Covey DF, Cistola DP. Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Biochemistry. 42: 11561-7. PMID 14529265 DOI: 10.1021/Bi0346502  1
2003 Westover EJ, Covey DF. First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. Steroids. 68: 159-66. PMID 12606007 DOI: 10.1016/S0039-128X(02)00174-5  1
2003 Darbandi-Tonkabon R, Hastings WR, Zeng CM, Akk G, Manion BD, Bracamontes JR, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of Biological Chemistry. 278: 13196-206. PMID 12560326 DOI: 10.1074/Jbc.M213168200  1
2003 Mannock DA, McIntosh TJ, Jiang X, Covey DF, McElhaney RN. Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. Biophysical Journal. 84: 1038-46. PMID 12547785 DOI: 10.1016/S0006-3495(03)74920-0  1
2003 Auchus RJ, Kumar AS, Boswell CA, Gupta MK, Bruce K, Rath NP, Covey DF. The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21 Archives of Biochemistry and Biophysics. 409: 134-144. PMID 12464252 DOI: 10.1016/S0003-9861(02)00491-5  1
2002 Liu R, Yang SH, Perez E, Yi KD, Wu SS, Eberst K, Prokai L, Prokai-Tatrai K, Cai ZY, Covey DF, Day AL, Simpkins JW. Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis. Stroke; a Journal of Cerebral Circulation. 33: 2485-91. PMID 12364742 DOI: 10.1161/01.Str.0000030317.43597.C8  1
2002 Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions. The Journal of Organic Chemistry. 67: 6764-71. PMID 12227809 DOI: 10.1021/Jo0259109  1
2002 Jiang X, Covey DF. Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon Journal of Organic Chemistry. 67: 4893-4900. PMID 12098302 DOI: 10.1021/Jo025535K  1
2002 Meyer DA, Carta M, Partridge LD, Covey DF, Valenzuela CF. Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors. The Journal of Biological Chemistry. 277: 28725-32. PMID 12042305 DOI: 10.1074/Jbc.M202592200  1
2002 Wang M, He Y, Eisenman LN, Fields C, Zeng CM, Mathews J, Benz A, Fu T, Zorumski E, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3366-75. PMID 11978813 DOI: 10.1523/Jneurosci.22-09-03366.2002  1
2002 Xia S, Cai ZY, Thio LL, Kim-Han JS, Dugan LL, Covey DF, Rothman SM. The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiology of Disease. 9: 282-93. PMID 11950274 DOI: 10.1006/Nbdi.2002.0478  1
2002 Ostlund RE, McGill JB, Zeng CM, Covey DF, Stearns J, Stenson WF, Spilburg CA. Gastrointestinal absorption and plasma kinetics of soy Δ5-phytosterols and phytostanols in humans American Journal of Physiology - Endocrinology and Metabolism. 282. PMID 11882512 DOI: 10.1152/Ajpendo.00328.2001  1
2002 Tochtrop GP, Richter K, Tang C, Toner JJ, Covey DF, Cistola DP. Energetics by NMR: site-specific binding in a positively cooperative system. Proceedings of the National Academy of Sciences of the United States of America. 99: 1847-52. PMID 11854486 DOI: 10.1073/Pnas.012379199  1
2002 Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions. Bioorganic & Medicinal Chemistry Letters. 12: 433-5. PMID 11814814 DOI: 10.1016/S0960-894X(01)00763-6  1
2002 He Y, Benz A, Fu T, Wang M, Covey DF, Zorumski CF, Mennerick S. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 42: 199-209. PMID 11804616 DOI: 10.1016/S0028-3908(01)00175-7  1
2001 Vallée M, Shen W, Heinrichs SC, Zorumski CF, Covey DF, Koob GF, Purdy RH. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats. The European Journal of Neuroscience. 14: 2003-10. PMID 11860495 DOI: 10.1046/J.0953-816X.2001.01817.X  1
2001 Covey DF, Evers AS, Mennerick S, Zorumski CF, Purdy RH. Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors. Brain Research. Brain Research Reviews. 37: 91-7. PMID 11744077 DOI: 10.1016/S0165-0173(01)00126-6  1
2001 Akwa Y, Ladurelle N, Covey DF, Baulieu EE. The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms? Proceedings of the National Academy of Sciences of the United States of America. 98: 14033-14037. PMID 11717462 DOI: 10.1073/Pnas.241503698  1
2001 Crowder CM, Westover EJ, Kumar AS, Ostlund RE, Covey DF. Enantiospecificity of cholesterol function in vivo. The Journal of Biological Chemistry. 276: 44369-72. PMID 11598105 DOI: 10.1074/Jbc.C100535200  1
2001 Mennerick S, Zeng CM, Benz A, Shen W, Izumi Y, Evers AS, Covey DF, Zorumski CF. Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission. Molecular Pharmacology. 60: 732-41. PMID 11562435  1
2001 Huang RQ, Bell-Horner CL, Dibas MI, Covey DF, Drewe JA, Dillon GH. Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action. The Journal of Pharmacology and Experimental Therapeutics. 298: 986-95. PMID 11504794  1
2001 Jiang X, Wang J, Hu J, Ge Z, Hu Y, Hu H, Covey DF. Synthesis of (5α)-17-azaandrostan-3-ols and (5α)-17-aza-D-homoandrostan-3-ols and their N-acylated derivatives Steroids. 66: 655-662. PMID 11430998 DOI: 10.1016/S0039-128X(01)00095-2  1
2001 Green PS, Yang SH, Nilsson KR, Kumar AS, Covey DF, Simpkins JW. The nonfeminizing enantiomer of 17β-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia Endocrinology. 142: 400-406. DOI: 10.1210/en.142.1.400  1
2001 Lalitha S, Sampath Kumar A, Stine KJ, Covey DF. Chirality in Membranes: First Evidence that Enantioselective Interactions Between Cholesterol and Cell Membrane Lipids Can Be a Determinant of Membrane Physical Properties Journal of Supramolecular Chemistry. 1: 53-61. DOI: 10.1016/S1472-7862(01)00013-2  1
2001 Lalitha S, Kumar AS, Stine KJ, Covey DF. Enantiospecificity of sterol-lipid interactions: First evidence that the absolute configuration of cholesterol affects the physical properties of cholesterol-sphingomyelin membranes Chemical Communications. 1192-1193.  1
2000 Zorumski CF, Mennerick S, Isenberg KE, Covey DF. Potential clinical uses of neuroactive steroids. Idrugs : the Investigational Drugs Journal. 3: 1053-63. PMID 16049865  1
2000 Zorumski CF, Mennerick S, Isenberg KE, Covey DF. Potential clinical uses of neuroactive steroids. Current Opinion in Investigational Drugs (London, England : 2000). 1: 360-9. PMID 11249720  1
2000 Chang Y, Covey DF, Weiss DS. Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. Molecular Pharmacology. 58: 1375-80. PMID 11093776 DOI: 10.1124/Mol.58.6.1375  1
2000 Abel E, De Wall SL, Edwards WB, Lalitha S, Covey DF, Gokel GW. Formation of stable vesicles from N- or 3-alkylindoles: possible evidence for tryptophan as a membrane anchor in proteins. The Journal of Organic Chemistry. 65: 5901-9. PMID 10987920 DOI: 10.1021/Jo000040L  1
2000 Covey DF, Han M, Kumar AS, de La Cruz MA, Meadows ES, Hu Y, Tonnies A, Nathan D, Coleman M, Benz A, Evers AS, Zorumski CF, Mennerick S. Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 43: 3201-4. PMID 10966737 DOI: 10.1021/Jm0002477  1
2000 Paradiso K, Sabey K, Evers AS, Zorumski CF, Covey DF, Steinbach JH. Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells. Molecular Pharmacology. 58: 341-51. PMID 10908302 DOI: 10.1124/Mol.58.2.341  1
2000 Covey DF, Nathan D, Kalkbrenner M, Nilsson KR, Hu Y, Zorumski CF, Evers AS. Enantioselectivity of pregnanolone-induced γ-aminobutyric acid(A) receptor modulation and anesthesia Journal of Pharmacology and Experimental Therapeutics. 293: 1009-1116. PMID 10869405  1
2000 Luker GD, Pica CM, Kumar AS, Covey DF, Piwnica-Worms D. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry. 39: 7651-61. PMID 10869171 DOI: 10.1021/Bi9928593  1
2000 Steinbach JH, Bracamontes J, Yu L, Zhang P, Covey DF. Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region Molecular Pharmacology. 58: 11-17. PMID 10860922 DOI: 10.1124/Mol.58.1.11  1
2000 Jiang X, Wang C, Hu Y, Hu H, Covey DF. A practical and facile route for the preparation of 18-norandrostan-17- ones from androstan-17-ones using SmI2-promoted cyclization and dehydroxylation Journal of Organic Chemistry. 65: 3555-3557. PMID 10843648 DOI: 10.1021/Jo991906U  1
2000 Shen W, Mennerick S, Covey DF, Zorumski CF. Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3571-9. PMID 10804198  1
2000 Xu W, Cormier R, Fu T, Covey DF, Isenberg KE, Zorumski CF, Mennerick S. Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3147-56. PMID 10777778 DOI: 10.1523/Jneurosci.20-09-03147.2000  1
2000 Zeng CM, Han M, Covey DF. Neurosteroid analogues. 7. A synthetic route for the conversion of 5β- methyl-3-ketosteroids into 7(S)-methyl-substituted analogues of neuroactive benz[e]indenes Journal of Organic Chemistry. 65: 2264-2266. PMID 10774062 DOI: 10.1021/Jo991953M  1
2000 Abel E, De Wall SL, Edwards WB, Lalitha S, Covey DF, Gokel GW. Aggregate formation from 3-alkylindoles: Amphiphilic models for interfacial helix anchoring groups Chemical Communications. 433-434.  1
1999 Hill MW, de la Cruz MA, Covey DF, Rothman SM. Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation. Epilepsy Research. 37: 121-31. PMID 10510978 DOI: 10.1016/S0920-1211(99)00041-8  1
1999 Nakashima YM, Pereverzev A, Schneider T, Covey DF, Lingle CJ. Blockade of Ba2+ current through human alpha1E channels by two steroid analogs, (+)-ACN and (+)-ECN. Neuropharmacology. 38: 843-55. PMID 10465688 DOI: 10.1016/S0028-3908(99)00013-1  1
1999 Shen W, Mennerick S, Zorumski EC, Covey DF, Zorumski CF. Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors. Neuropharmacology. 38: 267-71. PMID 10218867 DOI: 10.1016/S0028-3908(98)00172-5  1
1999 Luker GD, Nilsson KR, Covey DF, Piwnica-Worms D. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol Journal of Biological Chemistry. 274: 6979-6991. PMID 10066752 DOI: 10.1074/Jbc.274.11.6979  1
1999 Kumar AS, Covey DF. A new method for the preparation of Ent-cholesterol from Ent- testosterone Tetrahedron Letters. 40: 823-826. DOI: 10.1016/S0040-4039(98)02588-X  1
1998 Yamada KA, Hill MW, Hu Y, Covey DF. The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4- benzothiadiazine-S,S-dioxide augments AMPA- and GABA-mediated synaptic responses in cultured hippocampal neurons Neurobiology of Disease. 5: 196-205. PMID 9848091 DOI: 10.1006/Nbdi.1998.0196  1
1998 Nakashima YM, Todorovic SM, Covey DF, Lingle CJ. The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat. Molecular Pharmacology. 54: 559-68. PMID 9730915 DOI: 10.1124/Mol.54.3.559  1
1998 Nilsson KR, Zorumski CF, Covey DF. Neurosteroid analogues. 6. The synthesis and GABA(A) receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3α,5β)-3-hydroxypregnan-20-one sulfate Journal of Medicinal Chemistry. 41: 2604-2613. PMID 9651164 DOI: 10.1021/Jm980148H  1
1998 Hill MW, Reddy PA, Covey DF, Rothman SM. Inhibition of voltage-dependent sodium channels by the anticonvulsant gamma-aminobutyric acid type A receptor modulator, 3-benzyl-3-ethyl-2-piperidinone. The Journal of Pharmacology and Experimental Therapeutics. 285: 1303-9. PMID 9618437  1
1998 Zorumski CF, Mennerick SJ, Covey DF. Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures. Synapse (New York, N.Y.). 29: 162-71. PMID 9593106 DOI: 10.1002/(Sici)1098-2396(199806)29:2<162::Aid-Syn7>3.0.Co;2-5  1
1998 Yamada KA, Covey DF, Hsu CY, Hu R, Hu Y, He YY. The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury Annals of Neurology. 43: 664-669. PMID 9585363 DOI: 10.1002/Ana.410430517  1
1998 Bauman JL, Boucher BA, Bosso JA, Burckart GJ, Bussey HI, Chatto K, Covey DF, Cramer WR, Dasta JF, DeVane CL, Dukes GE, Elenbaas RM, Fagan SC, Garnett WR, Geraets DR, et al. The strategic plan of the American College of Clinical Pharmacy 1998- 2000 Pharmacotherapy. 18: 417-424. PMID 9545166  1
1998 Canney DJ, Lu HF, McKeon AC, Yoon KW, Xu K, Holland KD, Rothman SM, Ferrendelli JA, Covey DF. Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function. Bioorganic & Medicinal Chemistry. 6: 43-55. PMID 9502104 DOI: 10.1016/S0968-0896(97)10006-2  1
1997 Williams KL, Tucker JB, White G, Weiss DS, Ferrendelli JA, Covey DF, Krause JE, Rothman SM. Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site. Molecular Pharmacology. 52: 114-9. PMID 9224820 DOI: 10.1124/Mol.52.1.114  1
1997 Gross RA, Covey DF, Ferrendelli JA. Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones. The Journal of Pharmacology and Experimental Therapeutics. 280: 686-94. PMID 9023280  1
1997 Reddy PA, Woodward KE, McIlheran SM, Hsiang BC, Latifi TN, Hill MW, Rothman SM, Ferrendelli JA, Covey DF. Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams). Journal of Medicinal Chemistry. 40: 44-9. PMID 9016327 DOI: 10.1021/Jm960561U  1
1997 Hu Y, Wittmer LL, Kalkbrenner M, Evers AS, Zorumski CF, Covey DF. Neurosteroid analogues. Part 5. Enantiomers of neuroactive steroids and benz[e]indenes: Total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpoles Journal of the Chemical Society - Perkin Transactions 1. 3665-3671.  1
1996 Zorumski CF, Wittmer LL, Isenberg KE, Hu Y, Covey DF. Effects of neurosteroid and benz[e]indene enantiomers on GABA(A) receptors in cultured hippocampal neurons and transfected HEK-293 cells Neuropharmacology. 35: 1161-1168. PMID 9014131 DOI: 10.1016/S0028-3908(96)00035-4  1
1996 Wittmer LL, Hu Y, Kalkbrenner M, Evers AS, Zorumski CF, Covey DF. Enantioselectivity of steroid-induced γ-aminobutyric acidA receptor modulation and anesthesia Molecular Pharmacology. 50: 1581-1586. PMID 8967980  1
1996 Han M, Zorumski CF, Covey DF. Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABA(A) receptors Journal of Medicinal Chemistry. 39: 4218-4232. PMID 8863799 DOI: 10.1021/Jm960304P  1
1996 Mathews GC, Bolos-Sy AM, Covey DF, Rothman SM, Ferrendelli JA. Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors. Neuropharmacology. 35: 123-36. PMID 8734480 DOI: 10.1016/0028-3908(95)00180-8  1
1996 Reddy PA, Hsiang BC, Latifi TN, Hill MW, Woodward KE, Rothman SM, Ferrendelli JA, Covey DF. 3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents. Journal of Medicinal Chemistry. 39: 1898-906. PMID 8627613 DOI: 10.1021/Jm9600196  1
1996 Han M, Covey DF. An improved synthesis of 18-nor-17-ketosteroids and application of the method for the preparation of (3β,5β,13α)- and (3β,5β,13β)-3-hydroxygonan-17-one Journal of Organic Chemistry. 61: 7614-7616. DOI: 10.1021/Jo9611430  1
1996 Hu Y, Yamada KA, Chalmers DK, Annavajjula DP, Covey DF. Enenatioselective synthesis of cyclothiazide analogues: Novel probes of the stereospecific actions of benzothiadiazines at AMPA-type glutamate receptors Journal of the American Chemical Society. 118: 4550-4559. DOI: 10.1021/Ja9525317  1
1995 Xu M, Covey DF, Akabas MH. Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants. Biophysical Journal. 69: 1858-67. PMID 8580329 DOI: 10.1016/S0006-3495(95)80056-1  1
1995 Hu Y, Sherwin PF, Covey DF. Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-16-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer Steroids. 60: 250-255. PMID 7792826 DOI: 10.1016/0039-128X(94)00044-D  1
1995 Jakoby IV MG, Covey DF, Cistola DP. Localization of tolbutamide binding sites on human serum albumin using titration calorimetry and heteronuclear 2-D NMR Biochemistry. 34: 8780-8787. PMID 7612618 DOI: 10.1021/Bi00027A029  1
1995 Han M, Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5β- configuration Journal of Medicinal Chemistry. 38: 4548-4556. PMID 7473583 DOI: 10.1021/Jm00022A021  1
1995 Tinao-Wooldridge LV, Hsiang BCH, Latifi TN, Ferrendelli JA, Covey DF. Partial structures of the fungal toxin aflatrem, methyl-substituted 6,8-dioxabicyclo[3.2.1]octan-2-ones have anticonvulsant activity Bioorganic and Medicinal Chemistry Letters. 5: 265-270. DOI: 10.1016/0960-894X(95)00021-K  1
1995 Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues. 2. Total synthesis and electrophysiological evaluation of benz[e]indene analogues of the anesthetic steroid alphaxalone Journal of Organic Chemistry. 60: 3619-3625.  1
1994 Peterson EM, Xu K, Holland KD, McKeon AC, Rothman SM, Ferrendelli JA, Covey DF. Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. Journal of Medicinal Chemistry. 37: 275-86. PMID 8295215 DOI: 10.1021/Jm00028A011  1
1994 Mathews GC, Bolos-Sy AM, Holland KD, Isenberg KE, Covey DF, Ferrendelli JA, Rothman SM. Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons. Neuron. 13: 149-58. PMID 8043274 DOI: 10.1016/0896-6273(94)90465-0  1
1993 Covey DF, Hu Y, Bouley MG, Holland KD, Rodgers-Neame NT, Isenberg KE, Zorumski CF. Modulation of GABAA receptor function by benz[e]indenes and phenanthrenes Journal of Medicinal Chemistry. 36: 627-630. PMID 8388475 DOI: 10.1021/Jm00057A012  1
1993 Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of gabaA receptor function. 1. the effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles Journal of Medicinal Chemistry®. 36: 3956-3967. PMID 8254624 DOI: 10.1021/Jm00076A025  1
1993 Yoon KW, Covey DF, Rothman SM. Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons. The Journal of Physiology. 464: 423-39. PMID 8229811 DOI: 10.1113/Jphysiol.1993.Sp019643  1
1990 Holland KD, Ferrendelli JA, Covey DF, Rothman SM. Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 1719-27. PMID 2355246 DOI: 10.1523/Jneurosci.10-06-01719.1990  1
1990 Holland KD, Canney DJ, Rothman SM, Ferrendelli JA, Covey DF. Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons. Brain Research. 516: 147-50. PMID 2163720 DOI: 10.1016/0006-8993(90)90910-4  1
1987 Naritoku DK, Levine JA, Covey DF, Ferrendelli JA. Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake. Biochemical Pharmacology. 36: 797-800. PMID 3566782 DOI: 10.1016/0006-2952(87)90165-1  1
1985 Auchus RJ, Wilson DB, Covey DF, Majerus PW. The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells Biochemical and Biophysical Research Communications. 130: 1139-1146. PMID 4026861 DOI: 10.1016/0006-291X(85)91734-6  1
1982 Penning TM, Covey DF. Inactivation of Δ5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids Journal of Steroid Biochemistry. 16: 691-699. PMID 7098483 DOI: 10.1016/0022-4731(82)90106-6  1
1981 Perel E, Davis SP, Covey DF, Killinger DW. Effects of 4-hydroxy-4-androstene-3,17-dione and 10-propargylestr-4-ene-3,17-dione on the metabolism of androstenedione in human breast carcinoma and breast adipose tissues Steroids. 38: 397-405. PMID 7314156 DOI: 10.1016/0039-128X(81)90074-X  1
1981 Penning TM, Covey DF, Talalay P. Inactivation of delta 5-3-oxo steroid isomerase with active-site-directed acetylenic steroids Biochemical Journal. 193: 217-227. PMID 7305923 DOI: 10.1042/Bj1930217  1
1979 Covey DF, Albert KA, Robinson CH. Model studies with enzyme inhibitors. Addition of nucleophiles to conjugated allenic 3-oxo-5,10-secosteroids Journal of the Chemical Society, Chemical Communications. 795-796. DOI: 10.1039/C39790000795  1
1978 Voigt W, Castro A, Covey DF, Robinson CH. Inhibition of testosterone 5 alpha-reductase by and antiandrogenicity of allenic 3-keto-5,10-secosteroids. Acta Endocrinologica. 87: 668-72. PMID 580152 DOI: 10.1530/acta.0.0870668  1
1978 Carrell HL, Glusker JP, Covey DF, Batzold FH, Robinson CH. Molecular Structures Of Substrates And Inhibitors Of Δ5-3-Keto Steroid Isomerase And Their Relevance To The Enzymic Mechanism Cheminform. 9. DOI: 10.1002/Chin.197839064  1
1977 Batzold FH, Benson AM, Covey DF, Robinson CH, Talalay P. [51] Irreversible inhibitors of Δ 5-3-ketosteroid isomerase: Acetylenic and allenic 3-oxo-5,10-secosteroids Methods in Enzymology. 46: 461-468. PMID 909438 DOI: 10.1016/S0076-6879(77)46055-5  1
1977 Robaire B, Covey DF, Robinson CH, Ewing LL. Selective inhibition of rat epididymal steroid delta4-5alpha-reductase by conjugated allenic 3-oxo-5, 10-secosteroids. Journal of Steroid Biochemistry. 8: 307-10. PMID 886861 DOI: 10.1016/0022-4731(77)90024-3  1
1976 Covey DF, Robinson CH. Letter: Conjugated allenic 3-oxo-5,10-secosteroids. Irreversible inhibitors of delta 5-3-ketosteroid isomerase. Journal of the American Chemical Society. 98: 5038-40. PMID 950427 DOI: 10.1021/Ja00432A067  1
1976 Batzold FH, Benson AM, Covey DF, Robinson CH, Talalay P. The delta 5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition. Advances in Enzyme Regulation. 14: 243-67. PMID 9789 DOI: 10.1016/0065-2571(76)90016-9  1
1975 Nickon A, Covey DF, Pandit GD, Frank JJ. Regioselectivity and stereospecificity in homoketonizations. Control by thermodynamic and steric factors Tetrahedron Letters. 16: 3681-3684. DOI: 10.1016/S0040-4039(00)91307-8  1
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