| Year |
Citation |
Score |
| 2020 |
Wang X, Cai B, Yang X, Sonubi OO, Zheng Z, Ramakrishnan R, Shi H, Valenti L, Pajvani UB, Sandhu J, Infante RE, Radhakrishnan A, Covey DF, Guan KL, Buck J, et al. Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis. Cell Metabolism. PMID 32259482 DOI: 10.1016/J.Cmet.2020.03.010 |
0.322 |
|
| 2020 |
Smith CJ, Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Giner JL, Xie J, Covey DF, Wang C, Callahan BP. Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis. Biochemistry. PMID 32013401 DOI: 10.1021/Acs.Biochem.0C00013 |
0.329 |
|
| 2020 |
Wang X, Radhakrishnan A, Covey D, Horton J, Schwabe R, Tontonoz P, Guan K, Tabas I. Abstract B04: Hepatic cholesterol upregulates TAZ in nonalcoholic steatohepatitis Molecular Cancer Research. 18. DOI: 10.1158/1557-3125.Hippo19-B04 |
0.31 |
|
| 2019 |
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Cholesterol accessibility at the ciliary membrane controls Hedgehog signaling. Elife. 8. PMID 31657721 DOI: 10.7554/Elife.50051 |
0.315 |
|
| 2019 |
Rudolf AF, Kinnebrew M, Kowatsch C, Ansell TB, El Omari K, Bishop B, Pardon E, Schwab RA, Malinauskas T, Qian M, Duman R, Covey DF, Steyaert J, Wagner A, Sansom MSP, et al. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nature Chemical Biology. PMID 31548691 DOI: 10.1038/S41589-019-0370-Y |
0.357 |
|
| 2019 |
Petersen D, Reinholdt P, Szomek M, Hansen SK, Poongavanam V, Dupont A, Heegaard CW, Krishnan K, Fujiwara H, Covey DF, Ory DS, Kongsted J, Wüstner D. Binding and intracellular transport of 25-hydroxycholesterol by Niemann-Pick C2 protein. Biochimica Et Biophysica Acta. Biomembranes. 183063. PMID 31521631 DOI: 10.1016/J.Bbamem.2019.183063 |
0.339 |
|
| 2019 |
Cheng WWL, Budelier MM, Sugasawa Y, Bergdoll L, Queralt-Martín M, Rosencrans W, Rostovtseva TK, Chen ZW, Abramson J, Krishnan K, Covey DF, Whitelegge JP, Evers AS. Multiple neurosteroid and cholesterol binding sites in voltage-dependent anion channel-1 determined by photo-affinity labeling. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 31176038 DOI: 10.1016/J.Bbalip.2019.06.004 |
0.352 |
|
| 2019 |
Sugasawa Y, Bracamontes JR, Krishnan K, Covey DF, Reichert DE, Akk G, Chen Q, Tang P, Evers AS, Cheng WWL. The Molecular Determinants of Neurosteroid Binding in the GABA(A) Receptor. The Journal of Steroid Biochemistry and Molecular Biology. 105383. PMID 31150831 DOI: 10.1016/J.Jsbmb.2019.105383 |
0.312 |
|
| 2019 |
Feltes M, Moores S, Gale SE, Krishnan K, Mydock-McGrane L, Covey DF, Ory DS, Schaffer JE. Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking. Journal of Lipid Research. PMID 30617147 DOI: 10.1194/Jlr.D091470 |
0.361 |
|
| 2018 |
Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Kathiresan K, Mydock-McGrane L, Covey DF, Evers AS. Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. PMID 30471426 DOI: 10.1016/J.Bbalip.2018.11.005 |
0.355 |
|
| 2018 |
Shin DJ, Germann AL, Covey DF, Steinbach JH, Akk G. Analysis of GABAA receptor activation by combinations of agonists acting at the same or distinct binding sites. Molecular Pharmacology. PMID 30337372 DOI: 10.1124/Mol.118.113464 |
0.356 |
|
| 2018 |
Chisari M, Wilding TJ, Brunwasser S, Krishnan K, Qian M, Benz A, Huettner JE, Zorumski CF, Covey DF, Mennerick S. Visualizing pregnenolone sulfate-like modulators of NMDA receptor function reveals intracellular and plasma-membrane localization. Neuropharmacology. PMID 30332607 DOI: 10.1016/J.Neuropharm.2018.10.015 |
0.324 |
|
| 2018 |
Cheng WWL, Chen ZW, Bracamontes JR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS. Mapping Two Neurosteroid Modulatory Sites in the Prototypic Pentameric Ligand Gated Ion Channel GLIC. The Journal of Biological Chemistry. PMID 29301936 DOI: 10.1074/Jbc.Ra117.000359 |
0.306 |
|
| 2017 |
Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Janetka JW, Abramson J, Krishnan K, Mydock-McGrane L, Covey DF, Whitelegge JP, Evers AS. Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1. The Journal of Biological Chemistry. PMID 28396346 DOI: 10.1074/Jbc.M116.773069 |
0.361 |
|
| 2017 |
Castellano BM, Thelen AM, Moldavski O, Feltes M, van der Welle RE, Mydock-McGrane L, Jiang X, van Eijkeren RJ, Davis OB, Louie SM, Perera RM, Covey DF, Nomura DK, Ory DS, Zoncu R. Lysosomal cholesterol activates mTORC1 via an SLC38A9-Niemann-Pick C1 signaling complex. Science (New York, N.Y.). 355: 1306-1311. PMID 28336668 DOI: 10.1126/Science.Aag1417 |
0.326 |
|
| 2017 |
Brownholland DP, Covey DF. Synthesis of Side-Chain Oxysterols and their Enantiomers through Cross-Metathesis Reactions of Δ(22) Steroids. Steroids. PMID 28300584 DOI: 10.1016/J.Steroids.2017.03.002 |
0.302 |
|
| 2016 |
Engler-Chiurazzi EB, Covey DF, Simpkins JW. A novel mechanism of non-feminizing estrogens in neuroprotection. Experimental Gerontology. PMID 27818250 DOI: 10.1016/J.Exger.2016.10.013 |
0.331 |
|
| 2016 |
Qian M, Engler-Chiurazzi EB, Lewis SE, Rath NP, Simpkins JW, Covey DF. Structure-activity studies of non-steroid analogues structurally-related to neuroprotective estrogens. Organic & Biomolecular Chemistry. PMID 27714297 DOI: 10.1039/C6Ob01726F |
0.327 |
|
| 2016 |
Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R. Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling. Elife. 5. PMID 27705744 DOI: 10.7554/Elife.20304 |
0.336 |
|
| 2016 |
Jiang X, Shu HJ, Krishnan K, Qian M, Taylor AA, Covey DF, Zorumski CF, Mennerick S. A clickable neurosteroid photolabel reveals selective Golgi compartmentalization with preferential impact on proximal inhibition. Neuropharmacology. PMID 27114255 DOI: 10.1016/J.Neuropharm.2016.04.031 |
0.361 |
|
| 2016 |
Chakrabarti S, Qian M, Krishnan K, Covey DF, Mennerick S, Akk G. Comparison of Steroid Modulation of Spontaneous Inhibitory Postsynaptic Currents in Cultured Hippocampal Neurons and Steady-State Single-Channel Currents from Heterologously Expressed α1β2γ2L GABAA Receptors. Molecular Pharmacology. PMID 26769414 DOI: 10.1124/Mol.115.102202 |
0.303 |
|
| 2015 |
Horváth G, Bencsura Á, Simon Á, Tochtrop GP, DeKoster GT, Covey DF, Cistola DP, Toke O. Structural determinants of ligand binding in the ternary complex of human ileal bile acid-binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR. The Febs Journal. PMID 26613247 DOI: 10.1111/Febs.13610 |
0.764 |
|
| 2015 |
Iaea DB, Gale SE, Bielska AA, Krishnan K, Fujiwara H, Jiang H, Maxfield FR, Schlesinger PH, Covey DF, Schaffer JE, Ory DS. A novel intrinsically fluorescent probe for study of uptake and trafficking of 25-hydroxycholesterol. Journal of Lipid Research. PMID 26497473 DOI: 10.1194/Jlr.D064287 |
0.343 |
|
| 2015 |
Mydock-McGrane L, Rath NP, Covey DF. Correction to Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol. The Journal of Organic Chemistry. 80: 6000. PMID 25988770 DOI: 10.1021/Acs.Joc.5B01073 |
0.318 |
|
| 2014 |
Bandari S, Chakraborty H, Covey DF, Chattopadhyay A. Membrane dipole potential is sensitive to cholesterol stereospecificity: implications for receptor function. Chemistry and Physics of Lipids. 184: 25-9. PMID 25219773 DOI: 10.1016/J.Chemphyslip.2014.09.001 |
0.335 |
|
| 2014 |
Linsenbardt AJ, Taylor A, Emnett CM, Doherty JJ, Krishnan K, Covey DF, Paul SM, Zorumski CF, Mennerick S. Different oxysterols have opposing actions at N-methyl-D-aspartate receptors. Neuropharmacology. 85: 232-42. PMID 24878244 DOI: 10.1016/J.Neuropharm.2014.05.027 |
0.357 |
|
| 2014 |
Mydock-McGrane L, Rath NP, Covey DF. Synthesis of a smoothened cholesterol: 18,19-di-nor-cholesterol. The Journal of Organic Chemistry. 79: 5636-43. PMID 24823889 DOI: 10.1021/Jo500813N |
0.362 |
|
| 2014 |
Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS. Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry. 53: 3042-51. PMID 24758724 DOI: 10.1021/Bi5000096 |
0.332 |
|
| 2014 |
Chen ZW, Wang C, Krishnan K, Manion BD, Hastings R, Bracamontes J, Taylor A, Eaton MM, Zorumski CF, Steinbach JH, Akk G, Mennerick S, Covey DF, Evers AS. 11-trifluoromethyl-phenyldiazirinyl neurosteroid analogues: potent general anesthetics and photolabeling reagents for GABAA receptors. Psychopharmacology. 231: 3479-91. PMID 24756762 DOI: 10.1007/S00213-014-3568-4 |
0.359 |
|
| 2014 |
Peyrot SM, Nachtergaele S, Luchetti G, Mydock-McGrane LK, Fujiwara H, Scherrer D, Jallouk A, Schlesinger PH, Ory DS, Covey DF, Rohatgi R. Tracking the subcellular fate of 20(s)-hydroxycholesterol with click chemistry reveals a transport pathway to the Golgi. The Journal of Biological Chemistry. 289: 11095-110. PMID 24596093 DOI: 10.1074/Jbc.M113.540351 |
0.303 |
|
| 2014 |
Qian M, Krishnan K, Kudova E, Li P, Manion BD, Taylor A, Elias G, Akk G, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 18. Structure-activity studies of ent-steroid potentiators of γ-aminobutyric acid type A receptors and comparison of their activities with those of alphaxalone and allopregnanolone. Journal of Medicinal Chemistry. 57: 171-90. PMID 24328079 DOI: 10.1021/Jm401577C |
0.699 |
|
| 2014 |
Drews A, Mohr F, Rizun O, Wagner TF, Dembla S, Rudolph S, Lambert S, Konrad M, Philipp SE, Behrendt M, Marchais-Oberwinkler S, Covey DF, Oberwinkler J. Structural requirements of steroidal agonists of transient receptor potential melastatin 3 (TRPM3) cation channels. British Journal of Pharmacology. 171: 1019-32. PMID 24251620 DOI: 10.1111/Bph.12521 |
0.324 |
|
| 2014 |
Jafurulla M, Rao BD, Sreedevi S, Ruysschaert JM, Covey DF, Chattopadhyay A. Stereospecific requirement of cholesterol in the function of the serotonin1A receptor. Biochimica Et Biophysica Acta. 1838: 158-63. PMID 24008092 DOI: 10.1016/J.Bbamem.2013.08.015 |
0.367 |
|
| 2013 |
Olsen BN, Bielska AA, Lee T, Daily MD, Covey DF, Schlesinger PH, Baker NA, Ory DS. The structural basis of cholesterol accessibility in membranes. Biophysical Journal. 105: 1838-47. PMID 24138860 DOI: 10.1016/J.Bpj.2013.08.042 |
0.338 |
|
| 2012 |
Chen ZW, Manion B, Townsend RR, Reichert DE, Covey DF, Steinbach JH, Sieghart W, Fuchs K, Evers AS. Neurosteroid analog photolabeling of a site in the third transmembrane domain of the β3 subunit of the GABA(A) receptor. Molecular Pharmacology. 82: 408-19. PMID 22648971 DOI: 10.1124/Mol.112.078410 |
0.33 |
|
| 2012 |
Bielska AA, Schlesinger P, Covey DF, Ory DS. Oxysterols as non-genomic regulators of cholesterol homeostasis. Trends in Endocrinology and Metabolism: Tem. 23: 99-106. PMID 22244444 DOI: 10.1016/J.Tem.2011.12.002 |
0.323 |
|
| 2012 |
Krishnan K, Manion BD, Taylor A, Bracamontes J, Steinbach JH, Reichert DE, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 17. Inverted binding orientations of androsterone enantiomers at the steroid potentiation site on γ-aminobutyric acid type A receptors. Journal of Medicinal Chemistry. 55: 1334-45. PMID 22191644 DOI: 10.1021/Jm2014925 |
0.372 |
|
| 2012 |
Shu HJ, Bracamontes J, Taylor A, Wu K, Eaton MM, Akk G, Manion B, Evers AS, Krishnan K, Covey DF, Zorumski CF, Steinbach JH, Mennerick S. Characteristics of concatemeric GABA(A) receptors containing α4/δ subunits expressed in Xenopus oocytes. British Journal of Pharmacology. 165: 2228-43. PMID 21950777 DOI: 10.1111/J.1476-5381.2011.01690.X |
0.315 |
|
| 2011 |
D'Avanzo N, Hyrc K, Enkvetchakul D, Covey DF, Nichols CG. Enantioselective protein-sterol interactions mediate regulation of both prokaryotic and eukaryotic inward rectifier K+ channels by cholesterol. Plos One. 6: e19393. PMID 21559361 DOI: 10.1371/Journal.Pone.0019393 |
0.314 |
|
| 2011 |
Stastna E, Krishnan K, Manion BD, Taylor A, Rath NP, Chen ZW, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 16. A new explanation for the lack of anesthetic effects of δ(16)-alphaxalone and identification of a δ(17(20)) analogue with potent anesthetic activity. Journal of Medicinal Chemistry. 54: 3926-34. PMID 21504158 DOI: 10.1021/Jm2002487 |
0.357 |
|
| 2011 |
Bielska AA, Ory DS, Covey DF. Synthesis of the enantiomer of the oxysterol-antagonist LY295427. Steroids. 76: 986-90. PMID 21470559 DOI: 10.1016/J.Steroids.2011.03.008 |
0.35 |
|
| 2010 |
Bandyopadhyaya AK, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 15. A comparative study of the anesthetic and GABAergic actions of alphaxalone, Δ16-alphaxalone and their corresponding 17-carbonitrile analogues. Bioorganic & Medicinal Chemistry Letters. 20: 6680-4. PMID 20875742 DOI: 10.1016/J.Bmcl.2010.09.008 |
0.358 |
|
| 2010 |
Akk G, Covey DF, Evers AS, Mennerick S, Zorumski CF, Steinbach JH. Kinetic and structural determinants for GABA-A receptor potentiation by neuroactive steroids. Current Neuropharmacology. 8: 18-25. PMID 20808543 DOI: 10.2174/157015910790909458 |
0.342 |
|
| 2010 |
Chisari M, Eisenman LN, Covey DF, Mennerick S, Zorumski CF. The sticky issue of neurosteroids and GABA(A) receptors. Trends in Neurosciences. 33: 299-306. PMID 20409596 DOI: 10.1016/J.Tins.2010.03.005 |
0.352 |
|
| 2010 |
Minogue S, Chu KM, Westover EJ, Covey DF, Hsuan JJ, Waugh MG. Relationship between phosphatidylinositol 4-phosphate synthesis, membrane organization, and lateral diffusion of PI4KIIalpha at the trans-Golgi network. Journal of Lipid Research. 51: 2314-24. PMID 20388919 DOI: 10.1194/Jlr.M005751 |
0.776 |
|
| 2010 |
Evers AS, Chen ZW, Manion BD, Han M, Jiang X, Darbandi-Tonkabon R, Kable T, Bracamontes J, Zorumski CF, Mennerick S, Steinbach JH, Covey DF. A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors. The Journal of Pharmacology and Experimental Therapeutics. 333: 404-13. PMID 20124410 DOI: 10.1124/Jpet.109.164079 |
0.367 |
|
| 2010 |
CANNEY DJ, HOLLAND KD, LEVINE JA, MCKEON AC, FERRENDELLI JA, COVEY DF. ChemInform Abstract: Synthesis and Structure-Activity Studies of Alkyl-Substituted γ- Butyrolactones and γ-Thiobutyrolactones: Ligands for the Picrotoxin Receptor. Cheminform. 22: no-no. DOI: 10.1002/chin.199144152 |
0.689 |
|
| 2010 |
CANNEY DJ, LEVINE JA, LU H, COVEY DF. ChemInform Abstract: Facile Synthesis of α,β- and/or γ-Alkyl-Substituted . gamma.-Butyrolactones Using Readily Prepared Olefinic Esters. Cheminform. 22: no-no. DOI: 10.1002/chin.199109177 |
0.668 |
|
| 2010 |
Robinson CH, Covey DF. Biological formation and reactions The Chemistry of Ketenes, Allenes and Related Compounds: Part 1. 1: 451-485. DOI: 10.1002/9780470771600.ch13 |
0.472 |
|
| 2009 |
Li P, Bandyopadhyaya AK, Covey DF, Steinbach JH, Akk G. Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation. British Journal of Pharmacology. 158: 1322-9. PMID 19702782 DOI: 10.1111/J.1476-5381.2009.00390.X |
0.335 |
|
| 2009 |
Shu HJ, Eisenman LN, Wang C, Bandyopadhyaya AK, Krishnan K, Taylor A, Benz AM, Manion B, Evers AS, Covey DF, Zorumski CF, Mennerick S. Photodynamic effects of steroid-conjugated fluorophores on GABAA receptors. Molecular Pharmacology. 76: 754-65. PMID 19596835 DOI: 10.1124/Mol.109.057687 |
0.371 |
|
| 2009 |
Chisari M, Eisenman LN, Krishnan K, Bandyopadhyaya AK, Wang C, Taylor A, Benz A, Covey DF, Zorumski CF, Mennerick S. The influence of neuroactive steroid lipophilicity on GABAA receptor modulation: evidence for a low-affinity interaction. Journal of Neurophysiology. 102: 1254-64. PMID 19553485 DOI: 10.1152/Jn.00346.2009 |
0.371 |
|
| 2009 |
Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. The influence of the membrane on neurosteroid actions at GABA(A) receptors. Psychoneuroendocrinology. 34: S59-66. PMID 19541427 DOI: 10.1016/J.Psyneuen.2009.05.020 |
0.363 |
|
| 2009 |
Jin X, Covey DF, Steinbach JH. Kinetic analysis of voltage-dependent potentiation and block of the glycine alpha 3 receptor by a neuroactive steroid analogue. The Journal of Physiology. 587: 981-97. PMID 19124545 DOI: 10.1113/Jphysiol.2008.159343 |
0.306 |
|
| 2009 |
Katona BW, Anant S, Covey DF, Stenson WF. Characterization of enantiomeric bile acid-induced apoptosis in colon cancer cell lines. The Journal of Biological Chemistry. 284: 3354-64. PMID 19054763 DOI: 10.1074/Jbc.M805804200 |
0.585 |
|
| 2009 |
Gale SE, Westover EJ, Dudley N, Krishnan K, Merlin S, Scherrer DE, Han X, Zhai X, Brockman HL, Brown RE, Covey DF, Schaffer JE, Schlesinger P, Ory DS. Side chain oxygenated cholesterol regulates cellular cholesterol homeostasis through direct sterol-membrane interactions. The Journal of Biological Chemistry. 284: 1755-64. PMID 18996837 DOI: 10.1074/Jbc.M807210200 |
0.791 |
|
| 2008 |
Komarapuri S, Krishnan K, Covey DF. Synthesis of 19-Trideuterated ent-Testosterone and the GABA(A) Receptor Potentiators ent-Androsterone and ent-Etiocholanolone. Journal of Labelled Compounds & Radiopharmaceuticals. 51: 430-434. PMID 19122784 DOI: 10.1002/Jlcr.1558 |
0.334 |
|
| 2008 |
Akk G, Li P, Bracamontes J, Reichert DE, Covey DF, Steinbach JH. Mutations of the GABA-A receptor alpha1 subunit M1 domain reveal unexpected complexity for modulation by neuroactive steroids. Molecular Pharmacology. 74: 614-27. PMID 18544665 DOI: 10.1124/Mol.108.048520 |
0.308 |
|
| 2008 |
Scaglione JB, Jastrzebska I, Krishnan K, Li P, Akk G, Manion BD, Benz A, Taylor A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 14. Alternative ring system scaffolds: GABA modulatory and anesthetic actions of cyclopenta[b]phenanthrenes and cyclopenta[b]anthracenes. Journal of Medicinal Chemistry. 51: 1309-18. PMID 18275132 DOI: 10.1021/Jm701128R |
0.791 |
|
| 2008 |
Alakoskela JM, Sabatini K, Jiang X, Laitala V, Covey DF, Kinnunen PK. Enantiospecific interactions between cholesterol and phospholipids. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 830-6. PMID 18171092 DOI: 10.1021/La702909Q |
0.352 |
|
| 2008 |
Yi KD, Cai ZY, Covey DF, Simpkins JW. Estrogen receptor-independent neuroprotection via protein phosphatase preservation and attenuation of persistent extracellular signal-regulated kinase 1/2 activation. The Journal of Pharmacology and Experimental Therapeutics. 324: 1188-95. PMID 18089844 DOI: 10.1124/Jpet.107.132308 |
0.311 |
|
| 2008 |
Katona BW, Krishnan K, Cai ZY, Manion BD, Benz A, Taylor A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 12. Potent enhancement of GABA-mediated chloride currents at GABAA receptors by ent-androgens. European Journal of Medicinal Chemistry. 43: 107-13. PMID 17434649 DOI: 10.1016/J.Ejmech.2007.02.017 |
0.623 |
|
| 2007 |
Wang C, Rath NP, Covey DF. Neurosteroid Analogues. 13. Synthetic methods for the preparation of 2beta-hydroxygonane derivatives as structural mimics of ent-3alpha-hydroxysteroid modulators of GABA(A) receptors. Tetrahedron. 63: 7977-7984. PMID 18698337 DOI: 10.1016/J.Tet.2007.05.068 |
0.321 |
|
| 2007 |
Katona BW, Cummins CL, Ferguson AD, Li T, Schmidt DR, Mangelsdorf DJ, Covey DF. Synthesis, characterization, and receptor interaction profiles of enantiomeric bile acids. Journal of Medicinal Chemistry. 50: 6048-58. PMID 17963371 DOI: 10.1021/Jm0707931 |
0.618 |
|
| 2007 |
Katona BW, Rath NP, Anant S, Stenson WF, Covey DF. Enantiomeric deoxycholic acid: total synthesis, characterization, and preliminary toxicity toward colon cancer cell lines. The Journal of Organic Chemistry. 72: 9298-307. PMID 17958446 DOI: 10.1021/Jo701559Q |
0.615 |
|
| 2007 |
Li P, Shu HJ, Wang C, Mennerick S, Zorumski CF, Covey DF, Steinbach JH, Akk G. Neurosteroid migration to intracellular compartments reduces steroid concentration in the membrane and diminishes GABA-A receptor potentiation. The Journal of Physiology. 584: 789-800. PMID 17761771 DOI: 10.1113/Jphysiol.2007.142794 |
0.312 |
|
| 2007 |
Twede V, Tartaglia AL, Covey DF, Bamber BA. The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues. Molecular Pharmacology. 72: 1322-9. PMID 17715402 DOI: 10.1124/Mol.107.034058 |
0.327 |
|
| 2007 |
Kelley SP, Alan JK, O'Buckley TK, Mennerick S, Krishnan K, Covey DF, Leslie Morrow A. Antagonism of neurosteroid modulation of native gamma-aminobutyric acid receptors by (3alpha,5alpha)-17-phenylandrost-16-en-3-ol. European Journal of Pharmacology. 572: 94-101. PMID 17658511 DOI: 10.1016/J.Ejphar.2007.06.028 |
0.317 |
|
| 2007 |
Li W, Jin X, Covey DF, Steinbach JH. Neuroactive steroids and human recombinant rho1 GABAC receptors. The Journal of Pharmacology and Experimental Therapeutics. 323: 236-47. PMID 17636008 DOI: 10.1124/Jpet.107.127365 |
0.374 |
|
| 2007 |
Jastrzebska I, Scaglione JB, Dekoster GT, Rath NP, Covey DF. Palladium-catalyzed potassium enoxyborate alkylation of enantiopure Hajos-Parrish indenone to construct rearranged steroid ring systems. The Journal of Organic Chemistry. 72: 4837-43. PMID 17530900 DOI: 10.1021/Jo070530E |
0.771 |
|
| 2007 |
Akk G, Covey DF, Evers AS, Steinbach JH, Zorumski CF, Mennerick S. Mechanisms of neurosteroid interactions with GABA(A) receptors. Pharmacology & Therapeutics. 116: 35-57. PMID 17524487 DOI: 10.1016/J.Pharmthera.2007.03.004 |
0.345 |
|
| 2007 |
Li P, Bracamontes J, Katona BW, Covey DF, Steinbach JH, Akk G. Natural and enantiomeric etiocholanolone interact with distinct sites on the rat alpha1beta2gamma2L GABAA receptor. Molecular Pharmacology. 71: 1582-90. PMID 17341652 DOI: 10.1124/Mol.106.033407 |
0.607 |
|
| 2007 |
Eisenman LN, Shu HJ, Akk G, Wang C, Manion BD, Kress GJ, Evers AS, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. Anticonvulsant and anesthetic effects of a fluorescent neurosteroid analog activated by visible light. Nature Neuroscience. 10: 523-30. PMID 17322875 DOI: 10.1038/Nn1862 |
0.336 |
|
| 2007 |
Cai ZY, Covey DF. A facile total synthesis of ent-17beta-estradiol and structurally related analogues. Steroids. 72: 351-9. PMID 17257636 DOI: 10.1016/J.Steroids.2006.12.007 |
0.309 |
|
| 2007 |
Alakoskela JM, Covey DF, Kinnunen PK. Lack of enantiomeric specificity in the effects of anesthetic steroids on lipid bilayers. Biochimica Et Biophysica Acta. 1768: 131-45. PMID 16945324 DOI: 10.1016/J.Bbamem.2006.07.011 |
0.37 |
|
| 2006 |
Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon SH, Walkley SU, Covey DF, Schaffer JE, Ory DS. Pregnane X receptor (PXR) activation: a mechanism for neuroprotection in a mouse model of Niemann-Pick C disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 13807-12. PMID 16940355 DOI: 10.1073/Pnas.0606218103 |
0.322 |
|
| 2006 |
Westover EJ, Lin X, Riehl TE, Ma L, Stenson WF, Covey DF, Ostlund RE. Rapid transient absorption and biliary secretion of enantiomeric cholesterol in hamsters. Journal of Lipid Research. 47: 2374-81. PMID 16936324 DOI: 10.1194/Jlr.M600165-Jlr200 |
0.778 |
|
| 2006 |
VanLandingham JW, Cutler SM, Virmani S, Hoffman SW, Covey DF, Krishnan K, Hammes SR, Jamnongjit M, Stein DG. The enantiomer of progesterone acts as a molecular neuroprotectant after traumatic brain injury. Neuropharmacology. 51: 1078-85. PMID 16926035 DOI: 10.1016/J.Neuropharm.2006.07.015 |
0.303 |
|
| 2006 |
Yang C, McDonald JG, Patel A, Zhang Y, Umetani M, Xu F, Westover EJ, Covey DF, Mangelsdorf DJ, Cohen JC, Hobbs HH. Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. The Journal of Biological Chemistry. 281: 27816-26. PMID 16857673 DOI: 10.1074/Jbc.M603781200 |
0.8 |
|
| 2006 |
Scaglione JB, Manion BD, Benz A, Taylor A, DeKoster GT, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 11. Alternative ring system scaffolds: gamma-aminobutyric acid receptor modulation and anesthetic actions of benz[f]indenes. Journal of Medicinal Chemistry. 49: 4595-605. PMID 16854065 DOI: 10.1021/Jm0602920 |
0.781 |
|
| 2006 |
Li P, Covey DF, Steinbach JH, Akk G. Dual potentiating and inhibitory actions of a benz[e]indene neurosteroid analog on recombinant alpha1beta2gamma2 GABAA receptors. Molecular Pharmacology. 69: 2015-26. PMID 16554408 DOI: 10.1124/Mol.106.022590 |
0.363 |
|
| 2006 |
Li W, Covey DF, Alakoskela JM, Kinnunen PK, Steinbach JH. Enantiomers of neuroactive steroids support a specific interaction with the GABA-C receptor as the mechanism of steroid action. Molecular Pharmacology. 69: 1779-82. PMID 16527905 DOI: 10.1124/Mol.106.022863 |
0.367 |
|
| 2006 |
Westover EJ, Covey DF. Synthesis of ent-25-hydroxycholesterol. Steroids. 71: 484-8. PMID 16519912 DOI: 10.1016/J.Steroids.2006.01.007 |
0.78 |
|
| 2005 |
Akk G, Shu HJ, Wang C, Steinbach JH, Zorumski CF, Covey DF, Mennerick S. Neurosteroid access to the GABAA receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 11605-13. PMID 16354918 DOI: 10.1523/Jneurosci.4173-05.2005 |
0.326 |
|
| 2005 |
Cenedella RJ, Sexton PS, Krishnan K, Covey DF. Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis. Lipids. 40: 635-40. PMID 16149744 DOI: 10.1007/S11745-005-1426-9 |
0.331 |
|
| 2005 |
Liu J, Chang CC, Westover EJ, Covey DF, Chang TY. Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. The Biochemical Journal. 391: 389-97. PMID 15992359 DOI: 10.1042/Bj20050428 |
0.796 |
|
| 2005 |
Zeng CM, Manion BD, Benz A, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 10. The effect of methyl group substitution at the C-6 and C-7 positions on the GABA modulatory and anesthetic actions of (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 48: 3051-9. PMID 15828844 DOI: 10.1021/Jm049027+ |
0.356 |
|
| 2005 |
Kumar DM, Perez E, Cai ZY, Aoun P, Brun-Zinkernagel AM, Covey DF, Simpkins JW, Agarwal N. Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity. Free Radical Biology & Medicine. 38: 1152-63. PMID 15808412 DOI: 10.1016/J.Freeradbiomed.2004.12.007 |
0.317 |
|
| 2005 |
Perez E, Liu R, Yang SH, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of an estratriene analog are estrogen receptor independent in vitro and in vivo. Brain Research. 1038: 216-22. PMID 15757637 DOI: 10.1016/J.Brainres.2005.01.026 |
0.324 |
|
| 2005 |
Scaglione JB, Rath NP, Covey DF. First synthesis of enantiopure 1,6-difunctionalized dodecahydrobenz[f]indenes. The Journal of Organic Chemistry. 70: 1089-92. PMID 15675880 DOI: 10.1021/Jo048561M |
0.76 |
|
| 2005 |
Cegelski L, Rice CV, O'Connor RD, Caruano AL, Tochtrop GP, Cai ZY, Covey DF, Schaefer J. Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR Drug Development Research. 66: 93-102. DOI: 10.1002/Ddr.20048 |
0.647 |
|
| 2005 |
Perez E, Cai ZY, Covey DF, Simpkins JW. Neuroprotective effects of estratriene analogs: Structure-activity relationships and molecular optimization Drug Development Research. 66: 78-92. DOI: 10.1002/Ddr.20047 |
0.318 |
|
| 2004 |
Westover EJ, Covey DF. The enantiomer of cholesterol. The Journal of Membrane Biology. 202: 61-72. PMID 15702370 DOI: 10.1007/S00232-004-0714-7 |
0.772 |
|
| 2004 |
Simpkins JW, Yang SH, Liu R, Perez E, Cai ZY, Covey DF, Green PS. Estrogen-like compounds for ischemic neuroprotection. Stroke; a Journal of Cerebral Circulation. 35: 2648-51. PMID 15472107 DOI: 10.1161/01.Str.0000143734.59507.88 |
0.314 |
|
| 2004 |
Tochtrop GP, DeKoster GT, Covey DF, Cistola DP. A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein. Journal of the American Chemical Society. 126: 11024-9. PMID 15339188 DOI: 10.1021/Ja047589C |
0.762 |
|
| 2004 |
Shu HJ, Eisenman LN, Jinadasa D, Covey DF, Zorumski CF, Mennerick S. Slow actions of neuroactive steroids at GABAA receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6667-75. PMID 15282269 DOI: 10.1523/Jneurosci.1399-04.2004 |
0.334 |
|
| 2004 |
Li Y, Ge M, Ciani L, Kuriakose G, Westover EJ, Dura M, Covey DF, Freed JH, Maxfield FR, Lytton J, Tabas I. Enrichment of endoplasmic reticulum with cholesterol inhibits sarcoplasmic-endoplasmic reticulum calcium ATPase-2b activity in parallel with increased order of membrane lipids: implications for depletion of endoplasmic reticulum calcium stores and apoptosis in cholesterol-loaded macrophages. The Journal of Biological Chemistry. 279: 37030-9. PMID 15215242 DOI: 10.1074/Jbc.M405195200 |
0.774 |
|
| 2004 |
Akk G, Bracamontes JR, Covey DF, Evers A, Dao T, Steinbach JH. Neuroactive steroids have multiple actions to potentiate GABAA receptors. The Journal of Physiology. 558: 59-74. PMID 15146041 DOI: 10.1113/Jphysiol.2004.066571 |
0.318 |
|
| 2004 |
Mennerick S, He Y, Jiang X, Manion BD, Wang M, Shute A, Benz A, Evers AS, Covey DF, Zorumski CF. Selective antagonism of 5alpha-reduced neurosteroid effects at GABA(A) receptors. Molecular Pharmacology. 65: 1191-7. PMID 15102947 DOI: 10.1124/Mol.65.5.1191 |
0.314 |
|
| 2004 |
Das P, Bell-Horner CL, Huang RQ, Raut A, Gonzales EB, Chen ZL, Covey DF, Dillon GH. Inhibition of type A GABA receptors by L-type calcium channel blockers. Neuroscience. 124: 195-206. PMID 14960351 DOI: 10.1016/J.Neuroscience.2003.12.005 |
0.344 |
|
| 2004 |
Gonzales EB, Bell-Horner CL, de la Cruz MA, Ferrendelli JA, Covey DF, Dillon GH. Enantioselectivity of alpha-benzyl-alpha-methyl-gamma-butyrolactone-mediated modulation of anticonvulsant activity and GABA(A) receptor function. The Journal of Pharmacology and Experimental Therapeutics. 309: 677-83. PMID 14742738 DOI: 10.1124/Jpet.103.063008 |
0.34 |
|
| 2004 |
Darbandi-Tonkabon R, Manion BD, Hastings WR, Craigen WJ, Akk G, Bracamontes JR, He Y, Sheiko TV, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Neuroactive steroid interactions with voltage-dependent anion channels: lack of relationship to GABA(A) receptor modulation and anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 308: 502-11. PMID 14593090 DOI: 10.1124/Jpet.103.058123 |
0.342 |
|
| 2003 |
Jiang X, Manion BD, Benz A, Rath NP, Evers AS, Zorumski CF, Mennerick S, Covey DF. Neurosteroid analogues. 9. Conformationally constrained pregnanes: structure-activity studies of 13,24-cyclo-18,21-dinorcholane analogues of the GABA modulatory and anesthetic steroids (3alpha,5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 46: 5334-48. PMID 14640542 DOI: 10.1021/Jm030302M |
0.345 |
|
| 2003 |
Zitzer A, Westover EJ, Covey DF, Palmer M. Differential interaction of the two cholesterol-dependent, membrane-damaging toxins, streptolysin O and Vibrio cholerae cytolysin, with enantiomeric cholesterol. Febs Letters. 553: 229-31. PMID 14572629 DOI: 10.1016/S0014-5793(03)01023-8 |
0.783 |
|
| 2003 |
Westover EJ, Covey DF, Brockman HL, Brown RE, Pike LJ. Cholesterol depletion results in site-specific increases in epidermal growth factor receptor phosphorylation due to membrane level effects. Studies with cholesterol enantiomers. The Journal of Biological Chemistry. 278: 51125-33. PMID 14530278 DOI: 10.1074/Jbc.M304332200 |
0.793 |
|
| 2003 |
Tochtrop GP, Bruns JL, Tang C, Covey DF, Cistola DP. Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein. Biochemistry. 42: 11561-7. PMID 14529265 DOI: 10.1021/Bi0346502 |
0.772 |
|
| 2003 |
Westover EJ, Covey DF. First synthesis of ent-desmosterol and its conversion to ent-deuterocholesterol. Steroids. 68: 159-66. PMID 12606007 DOI: 10.1016/S0039-128X(02)00174-5 |
0.782 |
|
| 2003 |
Darbandi-Tonkabon R, Hastings WR, Zeng CM, Akk G, Manion BD, Bracamontes JR, Steinbach JH, Mennerick SJ, Covey DF, Evers AS. Photoaffinity labeling with a neuroactive steroid analogue. 6-azi-pregnanolone labels voltage-dependent anion channel-1 in rat brain. The Journal of Biological Chemistry. 278: 13196-206. PMID 12560326 DOI: 10.1074/Jbc.M213168200 |
0.33 |
|
| 2003 |
Mannock DA, McIntosh TJ, Jiang X, Covey DF, McElhaney RN. Effects of natural and enantiomeric cholesterol on the thermotropic phase behavior and structure of egg sphingomyelin bilayer membranes. Biophysical Journal. 84: 1038-46. PMID 12547785 DOI: 10.1016/S0006-3495(03)74920-0 |
0.329 |
|
| 2003 |
Auchus RJ, Kumar AS, Boswell CA, Gupta MK, Bruce K, Rath NP, Covey DF. The enantiomer of progesterone (ent-progesterone) is a competitive inhibitor of human cytochromes P450c17 and P450c21 Archives of Biochemistry and Biophysics. 409: 134-144. PMID 12464252 DOI: 10.1016/S0003-9861(02)00491-5 |
0.33 |
|
| 2002 |
Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. Synthesis of [3,4-(13)c(2)]-enriched bile salts as NMR probes of protein-ligand interactions. The Journal of Organic Chemistry. 67: 6764-71. PMID 12227809 DOI: 10.1021/Jo0259109 |
0.768 |
|
| 2002 |
Jiang X, Covey DF. Total synthesis of ent-cholesterol via a steroid C,D-ring side-chain synthon Journal of Organic Chemistry. 67: 4893-4900. PMID 12098302 DOI: 10.1021/Jo025535K |
0.344 |
|
| 2002 |
Meyer DA, Carta M, Partridge LD, Covey DF, Valenzuela CF. Neurosteroids enhance spontaneous glutamate release in hippocampal neurons. Possible role of metabotropic sigma1-like receptors. The Journal of Biological Chemistry. 277: 28725-32. PMID 12042305 DOI: 10.1074/Jbc.M202592200 |
0.303 |
|
| 2002 |
Wang M, He Y, Eisenman LN, Fields C, Zeng CM, Mathews J, Benz A, Fu T, Zorumski E, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. 3beta -hydroxypregnane steroids are pregnenolone sulfate-like GABA(A) receptor antagonists. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 3366-75. PMID 11978813 DOI: 10.1523/Jneurosci.22-09-03366.2002 |
0.307 |
|
| 2002 |
Xia S, Cai ZY, Thio LL, Kim-Han JS, Dugan LL, Covey DF, Rothman SM. The estrogen receptor is not essential for all estrogen neuroprotection: new evidence from a new analog. Neurobiology of Disease. 9: 282-93. PMID 11950274 DOI: 10.1006/Nbdi.2002.0478 |
0.3 |
|
| 2002 |
Tochtrop GP, Richter K, Tang C, Toner JJ, Covey DF, Cistola DP. Energetics by NMR: site-specific binding in a positively cooperative system. Proceedings of the National Academy of Sciences of the United States of America. 99: 1847-52. PMID 11854486 DOI: 10.1073/Pnas.012379199 |
0.752 |
|
| 2002 |
Tochtrop GP, DeKoster GT, Cistola DP, Covey DF. A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions. Bioorganic & Medicinal Chemistry Letters. 12: 433-5. PMID 11814814 DOI: 10.1016/S0960-894X(01)00763-6 |
0.758 |
|
| 2002 |
He Y, Benz A, Fu T, Wang M, Covey DF, Zorumski CF, Mennerick S. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 42: 199-209. PMID 11804616 DOI: 10.1016/S0028-3908(01)00175-7 |
0.309 |
|
| 2001 |
Vallée M, Shen W, Heinrichs SC, Zorumski CF, Covey DF, Koob GF, Purdy RH. Steroid structure and pharmacological properties determine the anti-amnesic effects of pregnenolone sulphate in the passive avoidance task in rats. The European Journal of Neuroscience. 14: 2003-10. PMID 11860495 DOI: 10.1046/J.0953-816X.2001.01817.X |
0.306 |
|
| 2001 |
Covey DF, Evers AS, Mennerick S, Zorumski CF, Purdy RH. Recent developments in structure-activity relationships for steroid modulators of GABA(A) receptors. Brain Research. Brain Research Reviews. 37: 91-7. PMID 11744077 DOI: 10.1016/S0165-0173(01)00126-6 |
0.355 |
|
| 2001 |
Crowder CM, Westover EJ, Kumar AS, Ostlund RE, Covey DF. Enantiospecificity of cholesterol function in vivo. The Journal of Biological Chemistry. 276: 44369-72. PMID 11598105 DOI: 10.1074/Jbc.C100535200 |
0.774 |
|
| 2001 |
Lalitha S, Sampath Kumar A, Stine KJ, Covey DF. Chirality in Membranes: First Evidence that Enantioselective Interactions Between Cholesterol and Cell Membrane Lipids Can Be a Determinant of Membrane Physical Properties Journal of Supramolecular Chemistry. 1: 53-61. DOI: 10.1016/S1472-7862(01)00013-2 |
0.343 |
|
| 2000 |
Chang Y, Covey DF, Weiss DS. Correlation of the apparent affinities and efficacies of gamma-aminobutyric acid(C) receptor agonists. Molecular Pharmacology. 58: 1375-80. PMID 11093776 DOI: 10.1124/Mol.58.6.1375 |
0.341 |
|
| 2000 |
Paradiso K, Sabey K, Evers AS, Zorumski CF, Covey DF, Steinbach JH. Steroid inhibition of rat neuronal nicotinic alpha4beta2 receptors expressed in HEK 293 cells. Molecular Pharmacology. 58: 341-51. PMID 10908302 DOI: 10.1124/Mol.58.2.341 |
0.34 |
|
| 2000 |
Luker GD, Pica CM, Kumar AS, Covey DF, Piwnica-Worms D. Effects of cholesterol and enantiomeric cholesterol on P-glycoprotein localization and function in low-density membrane domains. Biochemistry. 39: 7651-61. PMID 10869171 DOI: 10.1021/Bi9928593 |
0.328 |
|
| 1999 |
Hill MW, de la Cruz MA, Covey DF, Rothman SM. Effects of anticonvulsant lactams on in vitro seizures in the hippocampal slice preparation. Epilepsy Research. 37: 121-31. PMID 10510978 DOI: 10.1016/S0920-1211(99)00041-8 |
0.335 |
|
| 1999 |
Luker GD, Nilsson KR, Covey DF, Piwnica-Worms D. Multidrug resistance (MDR1) P-glycoprotein enhances esterification of plasma membrane cholesterol Journal of Biological Chemistry. 274: 6979-6991. PMID 10066752 DOI: 10.1074/Jbc.274.11.6979 |
0.312 |
|
| 1998 |
Nilsson KR, Zorumski CF, Covey DF. Neurosteroid analogues. 6. The synthesis and GABA(A) receptor pharmacology of enantiomers of dehydroepiandrosterone sulfate, pregnenolone sulfate, and (3α,5β)-3-hydroxypregnan-20-one sulfate Journal of Medicinal Chemistry. 41: 2604-2613. PMID 9651164 DOI: 10.1021/Jm980148H |
0.333 |
|
| 1998 |
Canney DJ, Lu HF, McKeon AC, Yoon KW, Xu K, Holland KD, Rothman SM, Ferrendelli JA, Covey DF. Structure-activity studies of fluoroalkyl-substituted gamma-butyrolactone and gamma-thiobutyrolactone modulators of GABA(A) receptor function. Bioorganic & Medicinal Chemistry. 6: 43-55. PMID 9502104 DOI: 10.1016/S0968-0896(97)10006-2 |
0.725 |
|
| 1997 |
Williams KL, Tucker JB, White G, Weiss DS, Ferrendelli JA, Covey DF, Krause JE, Rothman SM. Lactone modulation of the gamma-aminobutyric acid A receptor: evidence for a positive modulatory site. Molecular Pharmacology. 52: 114-9. PMID 9224820 DOI: 10.1124/Mol.52.1.114 |
0.317 |
|
| 1996 |
Zorumski CF, Wittmer LL, Isenberg KE, Hu Y, Covey DF. Effects of neurosteroid and benz[e]indene enantiomers on GABA(A) receptors in cultured hippocampal neurons and transfected HEK-293 cells Neuropharmacology. 35: 1161-1168. PMID 9014131 DOI: 10.1016/S0028-3908(96)00035-4 |
0.307 |
|
| 1996 |
Han M, Zorumski CF, Covey DF. Neurosteroid analogues. 4. The effect of methyl substitution at the C-5 and C-10 positions of neurosteroids on electrophysiological activity at GABA(A) receptors Journal of Medicinal Chemistry. 39: 4218-4232. PMID 8863799 DOI: 10.1021/Jm960304P |
0.34 |
|
| 1995 |
Jakoby IV MG, Covey DF, Cistola DP. Localization of tolbutamide binding sites on human serum albumin using titration calorimetry and heteronuclear 2-D NMR Biochemistry. 34: 8780-8787. PMID 7612618 DOI: 10.1021/Bi00027A029 |
0.632 |
|
| 1995 |
Han M, Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues. 3. The synthesis and electrophysiological evaluation of benz[e]indene congeners of neuroactive steroids having the 5β- configuration Journal of Medicinal Chemistry. 38: 4548-4556. PMID 7473583 DOI: 10.1021/Jm00022A021 |
0.325 |
|
| 1995 |
Tinao-Wooldridge LV, Hsiang BCH, Latifi TN, Ferrendelli JA, Covey DF. Partial structures of the fungal toxin aflatrem, methyl-substituted 6,8-dioxabicyclo[3.2.1]octan-2-ones have anticonvulsant activity Bioorganic and Medicinal Chemistry Letters. 5: 265-270. DOI: 10.1016/0960-894X(95)00021-K |
0.322 |
|
| 1994 |
Peterson EM, Xu K, Holland KD, McKeon AC, Rothman SM, Ferrendelli JA, Covey DF. Alpha-spirocyclopentyl- and alpha-spirocyclopropyl-gamma-butyrolactones: conformationally constrained derivatives of anticonvulsant and convulsant alpha,alpha-disubstituted gamma-butyrolactones. Journal of Medicinal Chemistry. 37: 275-86. PMID 8295215 DOI: 10.1021/Jm00028A011 |
0.323 |
|
| 1994 |
Mathews GC, Bolos-Sy AM, Holland KD, Isenberg KE, Covey DF, Ferrendelli JA, Rothman SM. Developmental alteration in GABAA receptor structure and physiological properties in cultured cerebellar granule neurons. Neuron. 13: 149-58. PMID 8043274 DOI: 10.1016/0896-6273(94)90465-0 |
0.314 |
|
| 1993 |
Canney DJ, Covey DF, Evers AS. Direct observation of a fluorinated anticonvulsant in brain tissue using 19F-NMR techniques. Biochemical Pharmacology. 45: 949-59. PMID 8452571 DOI: 10.1016/0006-2952(93)90181-U |
0.695 |
|
| 1993 |
Holland KD, Bouley MG, Covey DF, Ferrendelli JA. Alkyl-substituted gamma-butyrolactones act at a distinct site allosterically linked to the TBPS/picrotoxinin site on the GABAA receptor complex. Brain Research. 615: 170-4. PMID 8395954 DOI: 10.1016/0006-8993(93)91128-F |
0.356 |
|
| 1993 |
Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues: structure-activity studies of benz[e]indene modulators of gabaA receptor function. 1. the effect of 6-methyl substitution on the electrophysiological activity of 7-substituted benz[e]indene-3-carbonitriles Journal of Medicinal Chemistry®. 36: 3956-3967. PMID 8254624 DOI: 10.1021/Jm00076A025 |
0.323 |
|
| 1993 |
Yoon KW, Covey DF, Rothman SM. Multiple mechanisms of picrotoxin block of GABA-induced currents in rat hippocampal neurons. The Journal of Physiology. 464: 423-39. PMID 8229811 DOI: 10.1113/Jphysiol.1993.Sp019643 |
0.316 |
|
| 1993 |
Holland KD, McKeon AC, Canney DJ, Covey DF, Ferrendelli JA. Relative anticonvulsant effects of GABAmimetic and GABA modulatory agents. Epilepsia. 33: 981-6. PMID 1334454 DOI: 10.1111/J.1528-1157.1992.Tb01747.X |
0.701 |
|
| 1992 |
Thomas JL, Strickler RC, Myers RP, Covey DF. Affinity labeling of human placental 3 beta-hydroxy-delta 5-steroid dehydrogenase and steroid delta-isomerase: evidence for bifunctional catalysis by a different conformation of the same protein for each enzyme activity. Biochemistry. 31: 5522-7. PMID 1610797 DOI: 10.1021/Bi00139A014 |
0.324 |
|
| 1991 |
Canney DJ, Holland KD, Levine JA, McKeon AC, Ferrendelli JA, Covey DF. Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor. Journal of Medicinal Chemistry. 34: 1460-7. PMID 1849999 DOI: 10.1021/Jm00108A034 |
0.725 |
|
| 1990 |
Holland KD, Canney DJ, Rothman SM, Ferrendelli JA, Covey DF. Physiological modulation of the GABA receptor by convulsant and anticonvulsant barbiturates in cultured rat hippocampal neurons. Brain Research. 516: 147-50. PMID 2163720 DOI: 10.1016/0006-8993(90)90910-4 |
0.695 |
|
| 1990 |
Canney DJ, Levine JA, Lu H, Covey DF. Facile Synthesis of α, β, and/or γ-Alkyl-Substituted γ-Butyrolactones Using Readily Prepared Olefinic Esters Synthetic Communications. 20: 2065-2073. DOI: 10.1080/00397919008053138 |
0.695 |
|
| 1989 |
Sherwin PF, McMullan PC, Covey DF. Effects of steroid D-ring modification on suicide inactivation and competitive inhibition of aromatase by analogues of androsta-1,4-diene-3,17-dione. Journal of Medicinal Chemistry. 32: 651-8. PMID 2918514 DOI: 10.1021/Jm00123A026 |
0.31 |
|
| 1989 |
Auchus RJ, Palmer JO, Carrell HL, Covey DF. Preparation of 14,15-secoestra-1,3,5(10)-trien-15-ynes, inhibitors of estradiol dehydrogenase. Steroids. 53: 77-96. PMID 2772972 DOI: 10.1016/0039-128X(89)90147-5 |
0.357 |
|
| 1986 |
Covey DF, Hood WF, McMullan PC. Studies of the inactivation of human placental aromatase by 17 alpha-ethynyl-substituted 10 beta-hydroperoxy and related 19-nor steroids. Biochemical Pharmacology. 35: 1671-4. PMID 3707596 DOI: 10.1016/0006-2952(86)90321-7 |
0.325 |
|
| 1981 |
Penning TM, Covey DF, Talalay P. Inactivation of delta 5-3-oxo steroid isomerase with active-site-directed acetylenic steroids Biochemical Journal. 193: 217-227. PMID 7305923 DOI: 10.1042/Bj1930217 |
0.348 |
|
| 1980 |
Highet RJ, Covey DF, Robinson CH. Carbon-13 nuclear magnetic resonance spectra of 5,10-secosteroids. A transannular intramolecular hydrogen bond The Journal of Organic Chemistry. 45: 3286-3289. DOI: 10.1021/Jo01304A029 |
0.527 |
|
| 1979 |
Covey DF, Albert KA, Robinson CH. Model studies with enzyme inhibitors. Addition of nucleophiles to conjugated allenic 3-oxo-5,10-secosteroids Journal of the Chemical Society, Chemical Communications. 795-796. DOI: 10.1039/C39790000795 |
0.561 |
|
| 1978 |
Voigt W, Castro A, Covey DF, Robinson CH. Inhibition of testosterone 5 alpha-reductase by and antiandrogenicity of allenic 3-keto-5,10-secosteroids. Acta Endocrinologica. 87: 668-72. PMID 580152 DOI: 10.1530/acta.0.0870668 |
0.502 |
|
| 1978 |
Carrell HL, Glusker JP, Covey DF, Batzold FH, Robinson CH. Molecular structures of substrates and inhibitors of .DELTA.5-3-keto steroid isomerase and their relevance to the enzymic mechanism Journal of the American Chemical Society. 100: 4282-4289. DOI: 10.1021/Ja00481A045 |
0.55 |
|
| 1978 |
Carrell HL, Glusker JP, Covey DF, Batzold FH, Robinson CH. Molecular Structures Of Substrates And Inhibitors Of Δ5-3-Keto Steroid Isomerase And Their Relevance To The Enzymic Mechanism Cheminform. 9. DOI: 10.1002/Chin.197839064 |
0.548 |
|
| 1977 |
Batzold FH, Benson AM, Covey DF, Robinson CH, Talalay P. [51] Irreversible inhibitors of Δ 5-3-ketosteroid isomerase: Acetylenic and allenic 3-oxo-5,10-secosteroids Methods in Enzymology. 46: 461-468. PMID 909438 DOI: 10.1016/S0076-6879(77)46055-5 |
0.575 |
|
| 1977 |
Robaire B, Covey DF, Robinson CH, Ewing LL. Selective inhibition of rat epididymal steroid delta4-5alpha-reductase by conjugated allenic 3-oxo-5, 10-secosteroids. Journal of Steroid Biochemistry. 8: 307-10. PMID 886861 DOI: 10.1016/0022-4731(77)90024-3 |
0.51 |
|
| 1977 |
Covey DF, Nickon A. Difunctionalized brendanes via thallium triacetate cleavage of the cyclopropyl ring of triaxane The Journal of Organic Chemistry. 42: 794-799. DOI: 10.1021/Jo00425A006 |
0.602 |
|
| 1977 |
Amzel LM, Covey DF, Fenselau C, Nickon A, Robinson CH. Organic structural analysis. J. B. Lambert, H. F. Shurvell, L. Berbit, R. G. Cooks, G. H. Stout, Macmillan Publishing Co. Inc., New York, N. Y., 1976. 596 pp. $22.95 Biological Mass Spectrometry. 4: vii-ix. DOI: 10.1002/Bms.1200040612 |
0.468 |
|
| 1976 |
Covey DF, Robinson CH. Letter: Conjugated allenic 3-oxo-5,10-secosteroids. Irreversible inhibitors of delta 5-3-ketosteroid isomerase. Journal of the American Chemical Society. 98: 5038-40. PMID 950427 DOI: 10.1021/Ja00432A067 |
0.554 |
|
| 1976 |
Batzold FH, Benson AM, Covey DF, Robinson CH, Talalay P. The delta 5-3-ketosteroid isomerase reaction: catalytic mechanism, specificity and inhibition. Advances in Enzyme Regulation. 14: 243-67. PMID 9789 DOI: 10.1016/0065-2571(76)90016-9 |
0.53 |
|
| 1976 |
Nickon A, Lambert JL, Oliver JE, Covey DF, Morgan J. .beta.-Epimerization and .gamma.-hydrogen abstraction via homoenolate ions Journal of the American Chemical Society. 98: 2593-2599. DOI: 10.1021/Ja00425A031 |
0.595 |
|
| 1976 |
COVEY DF, ROBINSON CH. ChemInform Abstract: CONJUGATED ALLENIC 3-OXO-5,10-SECOSTEROIDS. IRREVERSIBLE INHIBITORS OF Δ5-3-KETOSTEROID ISOMERASE Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/chin.197644355 |
0.508 |
|
| 1976 |
NICKON A, LAMBERT JL, OLIVER JE, COVEY DF, MORGAN J. ChemInform Abstract: β-EPIMERIZATION AND Γ-HYDROGEN ABSTRACTION VIA HOMOENOLATE IONS Chemischer Informationsdienst. 7: no-no. DOI: 10.1002/Chin.197628113 |
0.591 |
|
| 1975 |
Nickon A, Covey DF, Huang F, Kuo Y. Unusually facile bridgehead enolization. Locked boat forms in anti-Bredt olefins Journal of the American Chemical Society. 97: 904-905. DOI: 10.1021/Ja00837A043 |
0.592 |
|
| 1975 |
Nickon A, Covey DF, Pandit GD, Frank JJ. Regioselectivity and stereospecificity in homoketonizations. Control by thermodynamic and steric factors Tetrahedron Letters. 16: 3681-3684. DOI: 10.1016/S0040-4039(00)91307-8 |
0.542 |
|
| 1974 |
Nickon A, Frank JJ, Covey DF, Lin YI. Acid homoketonization with inversion of configuaration. Dramatic effect of water in control of stereochemistry Journal of the American Chemical Society. 96: 7574-7576. DOI: 10.1021/Ja00831A043 |
0.557 |
|
| 1973 |
HUNTER DH, JOHNSON AL, STOTHERS JB, NICKON A, LAMBERT JL, COVEY DF. ChemInform Abstract: (13)C-NMR-UNTERSUCHUNGEN 25. MITT. (13)C-NMR ZUR UEBERWACHUNG ANIONISCHER AUSTAUSCHPROZESSE, NICHT BENACHBARTE EPIMERISIERUNG UEBER HOMOENOLATIONEN UND ARYL-D-AUSTAUSCH Chemischer Informationsdienst. 4: no-no. DOI: 10.1002/Chin.197307129 |
0.602 |
|
| 1972 |
Hunter DH, Johnson AL, Stothers JB, Nickon A, Lambert JL, Covey DF. Carbon-13 nuclear magnetic resonance studies. XXV. Carbon-13 nuclear magnetic resonance as a monitor for anionic exchange processes. Remote epimerization via homoenolate ions and aryl D exchange Journal of the American Chemical Society. 94: 8582-8584. DOI: 10.1021/Ja00779A051 |
0.582 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 1997 |
Reddy PA, Woodward KE, McIlheran SM, Hsiang BC, Latifi TN, Hill MW, Rothman SM, Ferrendelli JA, Covey DF. Synthesis and anticonvulsant activities of 3,3-dialkyl- and 3-alkyl-3-benzyl-2-piperidinones (delta-valerolactams) and hexahydro-2H-azepin-2-ones (epsilon-caprolactams). Journal of Medicinal Chemistry. 40: 44-9. PMID 9016327 DOI: 10.1021/Jm960561U |
0.299 |
|
| 2013 |
Simpkins JW, Richardson TE, Yi KD, Perez E, Covey DF. Neuroprotection with non-feminizing estrogen analogues: an overlooked possible therapeutic strategy. Hormones and Behavior. 63: 278-83. PMID 22498694 DOI: 10.1016/J.Yhbeh.2012.03.013 |
0.298 |
|
| 1998 |
Todorovic SM, Prakriya M, Nakashima YM, Nilsson KR, Han M, Zorumski CF, Covey DF, Lingle CJ. Enantioselective blockade of T-type Ca2+ current in adult rat sensory neurons by a steroid that lacks gamma-aminobutyric acid-modulatory activity. Molecular Pharmacology. 54: 918-27. PMID 9804627 DOI: 10.1124/Mol.54.5.918 |
0.297 |
|
| 2014 |
Krause MR, Wang M, Mydock-McGrane L, Covey DF, Tejada E, Almeida PF, Regen SL. Eliminating the roughness in cholesterol's β-face: does it matter? Langmuir : the Acs Journal of Surfaces and Colloids. 30: 12114-8. PMID 25290635 DOI: 10.1021/La503075E |
0.296 |
|
| 2020 |
Tesic V, Joksimovic SM, Quillinan N, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Neuroactive steroids alphaxalone and CDNC24 are effective hypnotics and potentiators of GABA currents, but are not neurotoxic to the developing rat brain. British Journal of Anaesthesia. PMID 32151384 DOI: 10.1016/J.Bja.2020.01.013 |
0.296 |
|
| 2002 |
Liu R, Yang SH, Perez E, Yi KD, Wu SS, Eberst K, Prokai L, Prokai-Tatrai K, Cai ZY, Covey DF, Day AL, Simpkins JW. Neuroprotective effects of a novel non-receptor-binding estrogen analogue: in vitro and in vivo analysis. Stroke; a Journal of Cerebral Circulation. 33: 2485-91. PMID 12364742 DOI: 10.1161/01.Str.0000030317.43597.C8 |
0.295 |
|
| 2018 |
Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y. Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model. Scientific Reports. 8: 12851. PMID 30150786 DOI: 10.1038/S41598-018-31239-2 |
0.294 |
|
| 2000 |
Steinbach JH, Bracamontes J, Yu L, Zhang P, Covey DF. Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region Molecular Pharmacology. 58: 11-17. PMID 10860922 DOI: 10.1124/Mol.58.1.11 |
0.294 |
|
| 1996 |
Mathews GC, Bolos-Sy AM, Covey DF, Rothman SM, Ferrendelli JA. Physiological comparison of alpha-ethyl-alpha-methyl-gamma-thiobutyrolactone with benzodiazepine and barbiturate modulators of GABAA receptors. Neuropharmacology. 35: 123-36. PMID 8734480 DOI: 10.1016/0028-3908(95)00180-8 |
0.294 |
|
| 2010 |
Qian M, Covey DF. The Efficient and Enantiospecific Total Synthesis of Cyclopenta[b]phenanthrenes Structurally-related to Neurosteroids. Advanced Synthesis & Catalysis. 352: 2057-2061. PMID 22022301 DOI: 10.1002/Adsc.201000370 |
0.294 |
|
| 1990 |
Holland KD, Ferrendelli JA, Covey DF, Rothman SM. Physiological regulation of the picrotoxin receptor by gamma-butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 1719-27. PMID 2355246 DOI: 10.1523/Jneurosci.10-06-01719.1990 |
0.293 |
|
| 1994 |
Weiner SJ, Holl SM, Covey DF. Synthesis of13C,15N-enriched α-dicarbonyl model adducts to determine the utility of13c and15N NMR for studying mechanism-based inactivation of cytochromes P-450 by substituted dichloroacetamides Magnetic Resonance in Chemistry. 32: 122-127. DOI: 10.1002/Mrc.1260320212 |
0.293 |
|
| 1988 |
Covey DF, McMullan PC, Wixler LL, Cabell M. [19-14C]androstenedione: a new substrate for assaying aromatase and studying its reaction mechanism. Biochemical and Biophysical Research Communications. 157: 81-6. PMID 3196351 DOI: 10.1016/S0006-291X(88)80014-7 |
0.292 |
|
| 2005 |
Pathirathna S, Brimelow BC, Jagodic MM, Krishnan K, Jiang X, Zorumski CF, Mennerick S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. New evidence that both T-type calcium channels and GABAA channels are responsible for the potent peripheral analgesic effects of 5alpha-reduced neuroactive steroids. Pain. 114: 429-43. PMID 15777868 DOI: 10.1016/J.Pain.2005.01.009 |
0.292 |
|
| 2014 |
Mohr F, Goecke C, Drews A, Rizun O, Covey DF, Behrendt M, Oberwinkler J. Properties of the Steroid Binding Site of TRPM3 Channels Biophysical Journal. 106: 335a. DOI: 10.1016/J.Bpj.2013.11.1918 |
0.292 |
|
| 2011 |
Yi KD, Perez E, Yang S, Liu R, Covey DF, Simpkins JW. The assessment of non-feminizing estrogens for use in neuroprotection. Brain Research. 1379: 61-70. PMID 21111714 DOI: 10.1016/J.Brainres.2010.11.058 |
0.292 |
|
| 2006 |
Wang X, Dykens JA, Perez E, Liu R, Yang S, Covey DF, Simpkins JW. Neuroprotective effects of 17beta-estradiol and nonfeminizing estrogens against H2O2 toxicity in human neuroblastoma SK-N-SH cells. Molecular Pharmacology. 70: 395-404. PMID 16614138 DOI: 10.1124/Mol.106.022384 |
0.292 |
|
| 2016 |
Wei X, Song H, Yin L, Rizzo MG, Sidhu R, Covey DF, Ory DS, Semenkovich CF. Fatty acid synthesis configures the plasma membrane for inflammation in diabetes. Nature. PMID 27806377 DOI: 10.1038/Nature20117 |
0.291 |
|
| 2000 |
Xu W, Cormier R, Fu T, Covey DF, Isenberg KE, Zorumski CF, Mennerick S. Slow death of postnatal hippocampal neurons by GABA(A) receptor overactivation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3147-56. PMID 10777778 DOI: 10.1523/Jneurosci.20-09-03147.2000 |
0.291 |
|
| 2013 |
Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling. Elife. 2: e01340. PMID 24171105 DOI: 10.7554/Elife.01340 |
0.291 |
|
| 1999 |
Nakashima YM, Pereverzev A, Schneider T, Covey DF, Lingle CJ. Blockade of Ba2+ current through human alpha1E channels by two steroid analogs, (+)-ACN and (+)-ECN. Neuropharmacology. 38: 843-55. PMID 10465688 DOI: 10.1016/S0028-3908(99)00013-1 |
0.291 |
|
| 1998 |
Zorumski CF, Mennerick SJ, Covey DF. Enantioselective modulation of GABAergic synaptic transmission by steroids and benz[e]indenes in hippocampal microcultures. Synapse (New York, N.Y.). 29: 162-71. PMID 9593106 DOI: 10.1002/(Sici)1098-2396(199806)29:2<162::Aid-Syn7>3.0.Co;2-5 |
0.29 |
|
| 2008 |
Mennerick S, Lamberta M, Shu HJ, Hogins J, Wang C, Covey DF, Eisenman LN, Zorumski CF. Effects on membrane capacitance of steroids with antagonist properties at GABAA receptors. Biophysical Journal. 95: 176-85. PMID 18339741 DOI: 10.1529/Biophysj.107.124768 |
0.29 |
|
| 2006 |
Wang C, Rath NP, Covey DF. Abnormal Beckmann fragmentation/ring closing metathesis route for preparation of 18-nor-Delta-androgens and their 18-nor-13,17-epoxide derivatives. Tetrahedron Letters. 47: 7837-7839. PMID 17440602 DOI: 10.1016/J.Tetlet.2006.09.027 |
0.29 |
|
| 2016 |
Byrne EF, Sircar R, Miller PS, Hedger G, Luchetti G, Nachtergaele S, Tully MD, Mydock-McGrane L, Covey DF, Rambo RP, Sansom MS, Newstead S, Rohatgi R, Siebold C. Structural basis of Smoothened regulation by its extracellular domains. Nature. PMID 27437577 DOI: 10.1038/Nature18934 |
0.29 |
|
| 1982 |
Penning TM, Covey DF. Inactivation of Δ5-3-ketosteroid isomerase(s) from beef adrenal cortex by acetylenic ketosteroids Journal of Steroid Biochemistry. 16: 691-699. PMID 7098483 DOI: 10.1016/0022-4731(82)90106-6 |
0.29 |
|
| 1981 |
Covey DF, Hood WF. Enzyme-generated intermediates derived from 4-androstene-3,6,17-trione and 1,4,6-androstatriene-3,17-dione cause a time-dependent decrease in human placental aromatase activity. Endocrinology. 108: 1597-9. PMID 7472286 DOI: 10.1210/Endo-108-4-1597 |
0.29 |
|
| 2018 |
Budelier MM, Cheng WW, Bracamontes JR, Chen Z, Kathiresan K, Mydock-McGrane L, Covey DF, Evers AS. Cholesterol and Neurosteroids Bind Common Sites but Assume Different Orientations in a Pentameric Ligand Gated Ion Channel Biophysical Journal. 114: 197a-198a. DOI: 10.1016/J.Bpj.2017.11.1106 |
0.29 |
|
| 2011 |
Stastna E, Rath NP, Covey DF. The use of symmetry in enantioselective synthesis: four pairs of chrysene enantiomers prepared from 19-nortestosterone. Organic & Biomolecular Chemistry. 9: 4685-94. PMID 21541379 DOI: 10.1039/C1Ob05385J |
0.289 |
|
| 1996 |
Hu Y, Yamada KA, Chalmers DK, Annavajjula DP, Covey DF. Enenatioselective synthesis of cyclothiazide analogues: Novel probes of the stereospecific actions of benzothiadiazines at AMPA-type glutamate receptors Journal of the American Chemical Society. 118: 4550-4559. DOI: 10.1021/Ja9525317 |
0.289 |
|
| 2016 |
Luchetti G, Sircar R, Kong JH, Nachtergaele S, Sagner A, Byrne EF, Covey DF, Siebold C, Rohatgi R. Author response: Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling Elife. DOI: 10.7554/Elife.20304.015 |
0.288 |
|
| 2005 |
Pathirathna S, Todorovic SM, Covey DF, Jevtovic-Todorovic V. 5alpha-reduced neuroactive steroids alleviate thermal and mechanical hyperalgesia in rats with neuropathic pain. Pain. 117: 326-39. PMID 16150542 DOI: 10.1016/J.Pain.2005.06.019 |
0.288 |
|
| 2013 |
Zorumski CF, Paul SM, Izumi Y, Covey DF, Mennerick S. Neurosteroids, stress and depression: potential therapeutic opportunities. Neuroscience and Biobehavioral Reviews. 37: 109-22. PMID 23085210 DOI: 10.1016/J.Neubiorev.2012.10.005 |
0.288 |
|
| 1999 |
Shen W, Mennerick S, Zorumski EC, Covey DF, Zorumski CF. Pregnenolone sulfate and dehydroepiandrosterone sulfate inhibit GABA-gated chloride currents in Xenopus oocytes expressing picrotoxin-insensitive GABA(A) receptors. Neuropharmacology. 38: 267-71. PMID 10218867 DOI: 10.1016/S0028-3908(98)00172-5 |
0.288 |
|
| 2001 |
Jiang X, Wang J, Hu J, Ge Z, Hu Y, Hu H, Covey DF. Synthesis of (5α)-17-azaandrostan-3-ols and (5α)-17-aza-D-homoandrostan-3-ols and their N-acylated derivatives Steroids. 66: 655-662. PMID 11430998 DOI: 10.1016/S0039-128X(01)00095-2 |
0.288 |
|
| 1985 |
Auchus RJ, Wilson DB, Covey DF, Majerus PW. The 5-hydroxyl of myo-inositol is essential for uptake into HSDM1C1 mouse fibrosarcoma cells Biochemical and Biophysical Research Communications. 130: 1139-1146. PMID 4026861 DOI: 10.1016/0006-291X(85)91734-6 |
0.287 |
|
| 2000 |
Shen W, Mennerick S, Covey DF, Zorumski CF. Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization. The Journal of Neuroscience. 20: 3571-3579. DOI: 10.1523/Jneurosci.20-10-03571.2000 |
0.287 |
|
| 1986 |
Beusen DD, Kalman BL, Covey DF. Role of substrate conformational features in the stereospecificity of aromatase. Biochemistry. 25: 662-667. PMID 3955022 DOI: 10.1021/Bi00351A023 |
0.287 |
|
| 1987 |
Auchus RJ, Covey DF. Mechanism-based inactivation of 17 beta,20 alpha-hydroxysteroid dehydrogenase by an acetylenic secoestradiol. Biochemistry. 25: 7295-300. PMID 3467792 DOI: 10.1021/Bi00371A008 |
0.287 |
|
| 2018 |
Chen Z, Bracamontes J, Cheng WW, Budelier M, Kathiresan K, Qian M, Covey DF, Evers AS. Identification of Neurosteroid Binding Sites on GABAA Receptors using Photolabeling with Mass Spectrometry Biophysical Journal. 114: 25a. DOI: 10.1016/J.Bpj.2017.11.183 |
0.285 |
|
| 1998 |
Yamada KA, Hill MW, Hu Y, Covey DF. The diazoxide derivative 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4- benzothiadiazine-S,S-dioxide augments AMPA- and GABA-mediated synaptic responses in cultured hippocampal neurons Neurobiology of Disease. 5: 196-205. PMID 9848091 DOI: 10.1006/Nbdi.1998.0196 |
0.284 |
|
| 1998 |
Hill MW, Reddy PA, Covey DF, Rothman SM. Contribution of Subsaturating GABA Concentrations to IPSCs in Cultured Hippocampal Neurons The Journal of Neuroscience. 18: 5103-5111. DOI: 10.1523/Jneurosci.18-14-05103.1998 |
0.284 |
|
| 2005 |
O'Dell LE, Purdy RH, Covey DF, Richardson HN, Roberto M, Koob GF. Epipregnanolone and a novel synthetic neuroactive steroid reduce alcohol self-administration in rats. Pharmacology, Biochemistry, and Behavior. 81: 543-50. PMID 15950269 DOI: 10.1016/J.Pbb.2005.03.020 |
0.283 |
|
| 1988 |
Beusen DD, Carrell HL, Covey DF. Metabolism of 19-methyl-substituted steroids by human placental aromatase. Biochemistry. 26: 7833-41. PMID 3427108 DOI: 10.1021/Bi00398A045 |
0.281 |
|
| 1994 |
Schlegel BP, Pawlowski JE, Hu Y, Scolnick DM, Covey DF, Penning TM. Secosteroid mechanism-based inactivators and site-directed mutagenesis as probes for steroid hormone recognition by 3 alpha-hydroxysteroid dehydrogenase. Biochemistry. 33: 10367-74. PMID 8068673 DOI: 10.1021/Bi00200A017 |
0.281 |
|
| 2012 |
Chen ZW, Chen LH, Akentieva N, Lichti CF, Darbandi R, Hastings R, Covey DF, Reichert DE, Townsend RR, Evers AS. A neurosteroid analogue photolabeling reagent labels the colchicine-binding site on tubulin: a mass spectrometric analysis. Electrophoresis. 33: 666-74. PMID 22451060 DOI: 10.1002/Elps.201100434 |
0.28 |
|
| 2011 |
Sneitz N, Krishnan K, Covey DF, Finel M. Glucuronidation of the steroid enantiomers ent-17β-estradiol, ent-androsterone and ent-etiocholanolone by the human UDP-glucuronosyltransferases. The Journal of Steroid Biochemistry and Molecular Biology. 127: 282-8. PMID 21899827 DOI: 10.1016/J.Jsbmb.2011.08.008 |
0.28 |
|
| 2019 |
Molnar KS, Dunyak BM, Su B, Izrayelit Y, McGlasson-Naumann B, Hamilton PD, Qian M, Covey DF, Gestwicki JE, Makley LN, Andley UP. Mechanism of Action of VP1-001 in cryAB(R120G)-Associated and Age-Related Cataracts. Investigative Ophthalmology & Visual Science. 60: 3320-3331. PMID 31369034 DOI: 10.1167/Iovs.18-25647 |
0.28 |
|
| 2012 |
Nachtergaele S, Mydock LK, Krishnan K, Rammohan J, Schlesinger PH, Covey DF, Rohatgi R. Oxysterols are allosteric activators of the oncoprotein Smoothened. Nature Chemical Biology. 8: 211-20. PMID 22231273 DOI: 10.1038/Nchembio.765 |
0.279 |
|
| 2014 |
Eaton MM, Lim YB, Covey DF, Akk G. Modulation of the human ρ1 GABAA receptor by inhibitory steroids. Psychopharmacology. 231: 3467-78. PMID 24317445 DOI: 10.1007/S00213-013-3379-Z |
0.279 |
|
| 1986 |
Levine JA, Ferrendelli JA, Covey DF. Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents. Journal of Medicinal Chemistry. 29: 1996-9. PMID 3761317 DOI: 10.1021/Jm00160A032 |
0.278 |
|
| 2007 |
Ory D, Langmade SJ, Gale SE, Frolov A, Mohri I, Suzuki K, Mellon S, Walkley SU, Covey DF, S. J. 20 Pregnane X receptor (PXR) activation: A novel mechanism for neuroprotection in a mouse model of Niemann–Pick C disease Molecular Genetics and Metabolism. 92: 16. DOI: 10.1016/J.Ymgme.2007.08.025 |
0.278 |
|
| 2009 |
Yi KD, Covey DF, Simpkins JW. Mechanism of okadaic acid-induced neuronal death and the effect of estrogens. Journal of Neurochemistry. 108: 732-40. PMID 19054278 DOI: 10.1111/J.1471-4159.2008.05805.X |
0.277 |
|
| 1989 |
Covey DF, Carrell HL, Beusen DD. Metabolism of 19-methyl substituted steroids and a proposal for the third aromatase monooxygenation. Steroids. 50: 363-74. PMID 3332933 DOI: 10.1016/0039-128X(87)90025-0 |
0.276 |
|
| 1982 |
Klunk WE, McKeon A, Covey DF, Ferrendelli JA. Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs. Science (New York, N.Y.). 217: 1040-2. PMID 6810462 DOI: 10.1126/Science.6810462 |
0.276 |
|
| 2004 |
Dykens JA, Carroll AK, Wiley S, Covey DF, Cai ZY, Zhao L, Wen R. Photoreceptor preservation in the S334ter model of retinitis pigmentosa by a novel estradiol analog. Biochemical Pharmacology. 68: 1971-84. PMID 15476668 DOI: 10.1016/J.Bcp.2004.06.042 |
0.276 |
|
| 2001 |
Green PS, Yang SH, Nilsson KR, Kumar AS, Covey DF, Simpkins JW. The nonfeminizing enantiomer of 17beta-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia. Endocrinology. 142: 400-6. PMID 11145603 DOI: 10.1210/Endo.142.1.7888 |
0.276 |
|
| 1985 |
Levine JA, Ferrendelli JA, Covey DF. Convulsant and anti-convulsant gammabutyrolactones bind at the picrotoxinin/T-butylbicyclophosphorothionate (TBPS) receptor. Biochemical Pharmacology. 34: 4187-90. PMID 2998401 DOI: 10.1016/0006-2952(85)90218-7 |
0.276 |
|
| 1991 |
Brandt ME, Covey DF, Zimniski SJ. The effects of in vivo administration of 10-propargylestr-4-ene-3,17-dione on rat ovarian aromatase and estrogen levels. Journal of Enzyme Inhibition. 4: 143-52. PMID 2098521 DOI: 10.3109/14756369009040736 |
0.275 |
|
| 1996 |
Reddy PA, Hsiang BC, Latifi TN, Hill MW, Woodward KE, Rothman SM, Ferrendelli JA, Covey DF. 3,3-Dialkyl- and 3-alkyl-3-benzyl-substituted 2-pyrrolidinones: a new class of anticonvulsant agents. Journal of Medicinal Chemistry. 39: 1898-906. PMID 8627613 DOI: 10.1021/Jm9600196 |
0.273 |
|
| 2016 |
Jiang X, Sidhu R, Mydock-McGrane L, Hsu FF, Covey DF, Scherrer DE, Earley B, Gale SE, Farhat NY, Porter FD, Dietzen DJ, Orsini JJ, Berry-Kravis E, Zhang X, Reunert J, et al. Development of a bile acid-based newborn screen for Niemann-Pick disease type C. Science Translational Medicine. 8: 337ra63. PMID 27147587 DOI: 10.1126/Scitranslmed.Aaf2326 |
0.272 |
|
| 2017 |
Nåbo LJ, Modzel M, Krishnan K, Covey DF, Fujiwara H, Ory DS, Szomek M, Khandelia H, Wüstner D, Kongsted J. Structural design of intrinsically fluorescent oxysterols. Chemistry and Physics of Lipids. PMID 29287905 DOI: 10.1016/J.Chemphyslip.2017.12.005 |
0.272 |
|
| 1997 |
Hu Y, Wittmer LL, Kalkbrenner M, Evers AS, Zorumski CF, Covey DF. Neurosteroid analogues. Part 5.1 Enantiomers of neuroactive steroids and benz[e]indenes: total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpoles Journal of the Chemical Society-Perkin Transactions 1. 3665-3672. DOI: 10.1039/A703212I |
0.272 |
|
| 1988 |
Baker K, Yang J, Covey DF, Clifford DB, Zorumski CF. Alpha-substituted thiobutyrolactones potentiate GABA currents in voltage-clamped chick spinal cord neurons. Neuroscience Letters. 87: 133-8. PMID 2454424 DOI: 10.1016/0304-3940(88)90158-9 |
0.272 |
|
| 2011 |
Yuan C, Treistman SN, Covey DF, Chen M, Johnston LJ. Cholesterol Regulates the Basal Functions and Ethanol Sensitivity of Large Conductance, Ca2+-Sensitive K+ channel through Specific Cholesterol-Protein Interaction Biophysical Journal. 100: 583a. DOI: 10.1016/J.Bpj.2010.12.3369 |
0.271 |
|
| 1998 |
Yamada KA, Covey DF, Hsu CY, Hu R, Hu Y, He YY. The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury Annals of Neurology. 43: 664-669. PMID 9585363 DOI: 10.1002/Ana.410430517 |
0.271 |
|
| 1989 |
Zorumski CF, Yang J, Baker K, Covey DF, Clifford DB. Convulsant gamma-butyrolactones block GABA currents in cultured chick spinal cord neurons. Brain Research. 484: 102-10. PMID 2713674 DOI: 10.1016/0006-8993(89)90352-1 |
0.269 |
|
| 1995 |
Hu Y, Sherwin PF, Covey DF. Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer. Steroids. 60: 491-496. PMID 7676484 DOI: 10.1016/0039-128X(95)00062-U |
0.269 |
|
| 1995 |
Hu Y, Sherwin PF, Covey DF. Synthesis of (17R)- and (17S)-17-hydroxy-14, 15-secoandrost-4-en-16-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer Steroids. 60: 250-255. PMID 7792826 DOI: 10.1016/0039-128X(94)00044-D |
0.268 |
|
| 1981 |
Strickler RC, Covey DF, Tobias B. Study of 3 alpha, 20 beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site. Biochemistry. 19: 4950-4. PMID 6936053 DOI: 10.1021/Bi00563A002 |
0.268 |
|
| 2020 |
Lee SJ, Chen Z, Budelier M, Krishnan K, Covey DF, Evers AS, Nichols CG. The Molecular Mechanisms of Cholesterol Regulation of Kir Channels Revealed by Direct and Quantitative Approaches Biophysical Journal. 118: 191a. DOI: 10.1016/J.Bpj.2019.11.1157 |
0.268 |
|
| 1993 |
Covey DF, Hu Y, Bouley MG, Holland KD, Rodgers-Neame NT, Isenberg KE, Zorumski CF. Modulation of GABAA receptor function by benz[e]indenes and phenanthrenes Journal of Medicinal Chemistry. 36: 627-630. PMID 8388475 DOI: 10.1021/Jm00057A012 |
0.268 |
|
| 1995 |
Xu M, Covey DF, Akabas MH. Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants. Biophysical Journal. 69: 1858-67. PMID 8580329 DOI: 10.1016/S0006-3495(95)80056-1 |
0.267 |
|
| 1989 |
Ferrendelli JA, Holland KD, McKeon AC, Covey DF. Comparison of the anticonvulsant activities of ethosuximide, valproate, and a new anticonvulsant, thiobutyrolactone. Epilepsia. 30: 617-22. PMID 2507307 DOI: 10.1111/J.1528-1157.1989.Tb05482.X |
0.265 |
|
| 2020 |
Ishikawa M, Takaseki S, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y. The neurosteroid allopregnanolone protects retinal neurons by effects on autophagy and GABRs/GABA receptors in rat glaucoma models. Autophagy. 1-18. PMID 32070183 DOI: 10.1080/15548627.2020.1731270 |
0.265 |
|
| 2019 |
Kinnebrew M, Iverson EJ, Patel BB, Pusapati GV, Kong JH, Johnson KA, Luchetti G, Eckert KM, McDonald JG, Covey DF, Siebold C, Radhakrishnan A, Rohatgi R. Author response: Cholesterol accessibility at the ciliary membrane controls hedgehog signaling Elife. DOI: 10.7554/Elife.50051.025 |
0.264 |
|
| 1982 |
Covey DF, Parikh VD. Inhibitors of steroid biosynthesis: preparation of 5,10-secoestr-4-ynes The Journal of Organic Chemistry. 47: 5315-5318. DOI: 10.1021/Jo00148A017 |
0.264 |
|
| 1995 |
Hu Y, Zorumski CF, Covey DF. Neurosteroid Analogs. 2. Total Synthesis and Electrophysiological Evaluation of Benz[e]indene Analogs of the Anesthetic Steroid Alphaxalone Journal of Organic Chemistry. 60: 3619-3625. DOI: 10.1021/Jo00117A010 |
0.264 |
|
| 1988 |
Zimniski SJ, Brandt ME, Covey DF, Puett D. Inhibition of aromatase activity and of endocrine-responsive tumor growth by 10-propargylestr-4-ene-3, 17-dione and its 17-propionate derivative. Steroids. 50: 135-46. PMID 3504057 DOI: 10.1016/0039-128X(83)90067-3 |
0.263 |
|
| 1988 |
Brandt ME, Puett D, Covey DF, Zimniski SJ. Characterization of pregnant mare's serum gonadotropin-stimulated rat ovarian aromatase and its inhibition by 10-propargylestr-4-ene-3,17-dione. Journal of Steroid Biochemistry. 31: 317-24. PMID 3419162 DOI: 10.1016/0022-4731(88)90356-1 |
0.263 |
|
| 2007 |
Joksovic PM, Covey DF, Todorovic SM. Inhibition of T-type calcium current in the reticular thalamic nucleus by a novel neuroactive steroid. Annals of the New York Academy of Sciences. 1122: 83-94. PMID 18077566 DOI: 10.1196/Annals.1403.006 |
0.263 |
|
| 1987 |
Naritoku DK, Levine JA, Covey DF, Ferrendelli JA. Effects of anticonvulsant and convulsant gamma-butyrolactones and thiobutyrolactones on GABA-mediated chloride uptake. Biochemical Pharmacology. 36: 797-800. PMID 3566782 DOI: 10.1016/0006-2952(87)90165-1 |
0.262 |
|
| 2019 |
Griffiths WJ, Yutuc E, Abdel-Khalik J, Crick PJ, Hearn T, Dickson A, Bigger BW, Hoi-Yee Wu T, Goenka A, Ghosh A, Jones SA, Covey DF, Ory DS, Wang Y. Metabolism of Non-Enzymatically Derived Oxysterols: Clues from sterol metabolic disorders. Free Radical Biology & Medicine. PMID 31009661 DOI: 10.1016/J.Freeradbiomed.2019.04.020 |
0.261 |
|
| 2001 |
Akwa Y, Ladurelle N, Covey DF, Baulieu EE. The synthetic enantiomer of pregnenolone sulfate is very active on memory in rats and mice, even more so than its physiological neurosteroid counterpart: Distinct mechanisms? Proceedings of the National Academy of Sciences of the United States of America. 98: 14033-14037. PMID 11717462 DOI: 10.1073/Pnas.241503698 |
0.26 |
|
| 2004 |
Todorovic SM, Pathirathna S, Brimelow BC, Jagodic MM, Ko SH, Jiang X, Nilsson KR, Zorumski CF, Covey DF, Jevtovic-Todorovic V. 5beta-reduced neuroactive steroids are novel voltage-dependent blockers of T-type Ca2+ channels in rat sensory neurons in vitro and potent peripheral analgesics in vivo. Molecular Pharmacology. 66: 1223-35. PMID 15280444 DOI: 10.1124/Mol.104.002402 |
0.259 |
|
| 1998 |
Nakashima YM, Todorovic SM, Covey DF, Lingle CJ. The anesthetic steroid (+)-3alpha-hydroxy-5alpha-androstane-17beta-carbonitrile blocks N-, Q-, and R-type, but not L- and P-type, high voltage-activated Ca2+ current in hippocampal and dorsal root ganglion neurons of the rat. Molecular Pharmacology. 54: 559-68. PMID 9730915 DOI: 10.1124/Mol.54.3.559 |
0.259 |
|
| 1986 |
Covey DF, McMullan PC, Weaver AJ, Chien WW. Inactivation of Streptomyces hydrogenans 20 beta-hydroxysteroid dehydrogenase by an enzyme-generated ethoxyacetylenic ketone in the presence of a thiol. Biochemistry. 25: 7288-94. PMID 3467791 DOI: 10.1021/Bi00371A007 |
0.259 |
|
| 2007 |
Izumi Y, Murayama K, Tokuda K, Krishnan K, Covey DF, Zorumski CF. GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices. The European Journal of Neuroscience. 26: 1881-8. PMID 17883414 DOI: 10.1111/J.1460-9568.2007.05809.X |
0.258 |
|
| 2013 |
Blanc M, Hsieh WY, Robertson KA, Kropp KA, Forster T, Shui G, Lacaze P, Watterson S, Griffiths SJ, Spann NJ, Meljon A, Talbot S, Krishnan K, Covey DF, Wenk MR, et al. The transcription factor STAT-1 couples macrophage synthesis of 25-hydroxycholesterol to the interferon antiviral response. Immunity. 38: 106-18. PMID 23273843 DOI: 10.1016/J.Immuni.2012.11.004 |
0.258 |
|
| 2000 |
Zeng CM, Han M, Covey DF. Neurosteroid analogues. 7. A synthetic route for the conversion of 5β- methyl-3-ketosteroids into 7(S)-methyl-substituted analogues of neuroactive benz[e]indenes Journal of Organic Chemistry. 65: 2264-2266. PMID 10774062 DOI: 10.1021/Jo991953M |
0.257 |
|
| 2017 |
Budelier MM, Cheng WW, Bergdoll L, Chen ZW, Abramson J, Krishnan K, Qian M, Covey DF, Janetka JW, Evers AS. Click Chemistry Reagent for Identification of Sites of Covalent Ligand Incorporation in Integral Membrane Proteins. Analytical Chemistry. PMID 28194953 DOI: 10.1021/Acs.Analchem.6B05003 |
0.256 |
|
| 2009 |
Zampieri S, Mellon SH, Butters TD, Nevyjel M, Covey DF, Bembi B, Dardis A. Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. Journal of Cellular and Molecular Medicine. 13: 3786-96. PMID 18774957 DOI: 10.1111/J.1582-4934.2008.00493.X |
0.256 |
|
| 2019 |
Zorumski CF, Paul SM, Covey DF, Mennerick S. Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond. Neurobiology of Stress. 11: 100196. PMID 31649968 DOI: 10.1016/J.Ynstr.2019.100196 |
0.256 |
|
| 2000 |
Covey DF, Han M, Kumar AS, de La Cruz MA, Meadows ES, Hu Y, Tonnies A, Nathan D, Coleman M, Benz A, Evers AS, Zorumski CF, Mennerick S. Neurosteroid analogues. 8. Structure-activity studies of N-acylated 17a-aza-D-homosteroid analogues of the anesthetic steroids (3alpha, 5alpha)- and (3alpha,5beta)-3-hydroxypregnan-20-one. Journal of Medicinal Chemistry. 43: 3201-4. PMID 10966737 DOI: 10.1021/Jm0002477 |
0.255 |
|
| 1979 |
Covey DF. Synthesis of 17 beta-[(1S)-1-hydroxy-2-propynyl]- and 17 beta-[(1R)-1-hydroxy-2-propynyl]androst-4-en-3-one. Potential suicide substrates of 20 alpha- and 20 beta-hydroxysteroid dehydrogenases. Steroids. 34: 199-206. PMID 494361 DOI: 10.1016/0039-128X(79)90048-5 |
0.254 |
|
| 2009 |
Eisenman LN, Shu HJ, Wang C, Aizenman E, Covey DF, Zorumski CF, Mennerick S. NMDA potentiation by visible light in the presence of a fluorescent neurosteroid analogue. The Journal of Physiology. 587: 2937-47. PMID 19403611 DOI: 10.1113/Jphysiol.2009.172700 |
0.253 |
|
| 2002 |
Darbandi-Tonkabon R, Hastings R, Zeng C, Covey DF, Evers AS. Photoaffinity Labeling of a Neuroactive Steroid Binding Protein in Rat Brain Anesthesiology. 96: A814. DOI: 10.1097/00000542-200209002-00814 |
0.251 |
|
| 1987 |
Auchus RJ, d'Avignon A, Covey DF. A rare example of extremely strong carbon—carbon coupling: Analysis of13C and1H NMR spectra of a13C2-acetylenic ketone Magnetic Resonance in Chemistry. 25: 462-465. DOI: 10.1002/Mrc.1260250515 |
0.251 |
|
| 1981 |
Penning T, Covey D, Talalay P. AFFINITY LABELING OF Δ5 -3-KETOSTEROID ISOMERASE FROM PSEUDOMONAS TESTOSTERONI Biochemical Society Transactions. 9: 322P-322P. DOI: 10.1042/Bst009322Pa |
0.25 |
|
| 1985 |
Covey DF, Hood WF, Beusen DD, Carrell HL. Hydroperoxides as inactivators of aromatase: 10 beta-hydroperoxy-4-estrene-3,17-dione, crystal structure and inactivation characteristics. Biochemistry. 23: 5398-406. PMID 6509027 DOI: 10.1021/Bi00318A004 |
0.249 |
|
| 2021 |
Krishnan K, Qian M, Feltes M, Chen ZW, Gale S, Wang L, Sugasawa Y, Reichert DE, Schaffer JE, Ory DS, Evers AS, Covey DF. Validation of Trifluoromethylphenyl Diazirine Cholesterol Analogues As Cholesterol Mimetics and Photolabeling Reagents. Acs Chemical Biology. PMID 34355883 DOI: 10.1021/acschembio.1c00364 |
0.247 |
|
| 2014 |
Zolkowska D, Dhir A, Krishnan K, Covey DF, Rogawski MA. Anticonvulsant potencies of the enantiomers of the neurosteroids androsterone and etiocholanolone exceed those of the natural forms. Psychopharmacology. 231: 3325-32. PMID 24705905 DOI: 10.1007/S00213-014-3546-X |
0.247 |
|
| 2005 |
Evason K, Huang C, Yamben I, Covey DF, Kornfeld K. Anticonvulsant medications extend worm life-span. Science (New York, N.Y.). 307: 258-62. PMID 15653505 DOI: 10.1126/Science.1105299 |
0.247 |
|
| 2006 |
Pathirathna S, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Differential effects of endogenous cysteine analogs on peripheral thermal nociception in intact rats. Pain. 125: 53-64. PMID 16782275 DOI: 10.1016/J.Pain.2006.04.024 |
0.247 |
|
| 2000 |
Abel E, Wall SLD, Edwards WB, Lalitha S, Covey DF, Gokel GW. Aggregate formation from 3-alkylindoles: amphiphilicmodels for interfacial helix anchoring groups Chemical Communications. 433-434. DOI: 10.1039/A909527F |
0.245 |
|
| 2010 |
Handforth A, Homanics GE, Covey DF, Krishnan K, Lee JY, Sakimura K, Martin FC, Quesada A. T-type calcium channel antagonists suppress tremor in two mouse models of essential tremor. Neuropharmacology. 59: 380-7. PMID 20547167 DOI: 10.1016/J.Neuropharm.2010.05.012 |
0.244 |
|
| 1985 |
Heston WD, Uy L, Fair WR, Covey DF. Cytotoxic activity of aziridinyl putrescine enhanced by polyamine depletion with alpha-difluoromethylornithine. Biochemical Pharmacology. 34: 2409-10. PMID 3925954 DOI: 10.1016/0006-2952(85)90806-8 |
0.244 |
|
| 2006 |
Akwa Y, Dumas J, Nathalie L, Schumacher M, Krishnan K, Covey DF, Baulieu E. Pregnenolone sulfate (PREGS) and its synthetic enantiomer (ent-PREGS) stimulate memory performance in rats through common and differential activation of glutamatergic receptor signalling pathways Frontiers in Neuroendocrinology. 27: 21. DOI: 10.1016/J.Yfrne.2006.03.044 |
0.243 |
|
| 2016 |
Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y. TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model. Neuropharmacology. PMID 27596950 DOI: 10.1016/J.Neuropharm.2016.09.001 |
0.242 |
|
| 2009 |
Jevtovic-Todorovic V, Covey DF, Todorovic SM. Are neuroactive steroids promising therapeutic agents in the management of acute and chronic pain? Psychoneuroendocrinology. 34: S178-85. PMID 19577375 DOI: 10.1016/J.Psyneuen.2009.06.001 |
0.241 |
|
| 1983 |
Klunk WE, Covey DF, Ferrendelli JA. Alkyl-substituted gamma-butyrolactones as potential tools in the study and treatment of epilepsy. Biochemical Pharmacology. 32: 2999-3004. PMID 6315013 DOI: 10.1016/0006-2952(83)90240-X |
0.241 |
|
| 2000 |
Covey DF, Nathan D, Kalkbrenner M, Nilsson KR, Hu Y, Zorumski CF, Evers AS. Enantioselectivity of pregnanolone-induced γ-aminobutyric acid(A) receptor modulation and anesthesia Journal of Pharmacology and Experimental Therapeutics. 293: 1009-1116. PMID 10869405 |
0.24 |
|
| 1981 |
Perel E, Davis SP, Covey DF, Killinger DW. Effects of 4-hydroxy-4-androstene-3,17-dione and 10-propargylestr-4-ene-3,17-dione on the metabolism of androstenedione in human breast carcinoma and breast adipose tissues Steroids. 38: 397-405. PMID 7314156 DOI: 10.1016/0039-128X(81)90074-X |
0.24 |
|
| 2018 |
Joksimovic SL, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Neurosteroids in Pain Management: A New Perspective on an Old Player. Frontiers in Pharmacology. 9: 1127. PMID 30333753 DOI: 10.3389/Fphar.2018.01127 |
0.238 |
|
| 2019 |
Joksimovic SM, Izumi Y, Joksimovic SL, Tesic V, Krishnan K, Asnake B, Jevtovic-Todorovic V, Covey DF, Zorumski CF, Todorovic SM. Novel neurosteroid hypnotic blocks T-type calcium channel-dependent rebound burst firing and suppresses long-term potentiation in the rat subiculum. British Journal of Anaesthesia. PMID 30916017 DOI: 10.1016/J.Bja.2019.01.029 |
0.237 |
|
| 1996 |
Rothman SM, Yamada KA, Covey DF. Thiazide derivatives block rapid AMPA receptordesensitization European Neuropsychopharmacology. 6: 152. DOI: 10.1016/0924-977X(96)88007-2 |
0.237 |
|
| 2007 |
Bordet T, Buisson B, Michaud M, Drouot C, Galéa P, Delaage P, Akentieva NP, Evers AS, Covey DF, Ostuni MA, Lacapère JJ, Massaad C, Schumacher M, Steidl EM, Maux D, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. The Journal of Pharmacology and Experimental Therapeutics. 322: 709-20. PMID 17496168 DOI: 10.1124/Jpet.107.123000 |
0.236 |
|
| 1987 |
Auchus RJ, Covey DF. Dehydrogenase inactivation by an enzyme-generated acetylenic ketone: identification of a lysyl enaminone by carbon-13 NMR Journal of the American Chemical Society. 109: 280-282. DOI: 10.1021/Ja00235A047 |
0.236 |
|
| 2011 |
Petit GH, Tobin C, Krishnan K, Moricard Y, Covey DF, Rondi-Reig L, Akwa Y. Pregnenolone sulfate and its enantiomer: differential modulation of memory in a spatial discrimination task using forebrain NMDA receptor deficient mice. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 21: 211-5. PMID 21036556 DOI: 10.1016/J.Euroneuro.2010.09.010 |
0.233 |
|
| 2020 |
Wong MY, Lewis M, Doherty JJ, Shi Y, Cashikar AG, Amelianchik A, Tymchuk S, Sullivan PM, Qian M, Covey DF, Petsko GA, Holtzman DM, Paul SM, Luo W. 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. Journal of Neuroinflammation. 17: 192. PMID 32552741 DOI: 10.1186/S12974-020-01869-3 |
0.233 |
|
| 1981 |
Covey DF, Parikh VD. The addition of hypobromous acid to 3 beta, 17 beta-diacetoxy-4-estrene and an equilibration study involving neighboring group participation by the A-ring acetoxy group. Steroids. 36: 451-61. PMID 7444995 DOI: 10.1016/0039-128X(80)90032-X |
0.232 |
|
| 2011 |
Nachtergaele S, Mydock L, Krishnan K, Covey D, Rohatgi R. Abstract LB-238: Regulation of signaling pathways by endogenous small molecules Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-238 |
0.231 |
|
| 2000 |
Jiang X, Wang C, Hu Y, Hu H, Covey DF. A practical and facile route for the preparation of 18-norandrostan-17- ones from androstan-17-ones using SmI2-promoted cyclization and dehydroxylation Journal of Organic Chemistry. 65: 3555-3557. PMID 10843648 DOI: 10.1021/Jo991906U |
0.23 |
|
| 2002 |
Ostlund RE, McGill JB, Zeng CM, Covey DF, Stearns J, Stenson WF, Spilburg CA. Gastrointestinal absorption and plasma kinetics of soy Δ5-phytosterols and phytostanols in humans American Journal of Physiology - Endocrinology and Metabolism. 282. PMID 11882512 DOI: 10.1152/Ajpendo.00328.2001 |
0.229 |
|
| 2019 |
Joksimovic SL, Joksimovic SM, Manzella FM, Asnake B, Orestes P, Raol YH, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Novel neuroactive steroid with hypnotic and T-channel blocking properties exerts effective analgesia in a rodent model of post-surgical pain. British Journal of Pharmacology. PMID 31732978 DOI: 10.1111/Bph.14930 |
0.228 |
|
| 2018 |
Cheng WW, Chen Z, John BR, Budelier MM, Krishnan K, Shin DJ, Wang C, Jiang X, Covey DF, Akk G, Evers AS. Mapping Two Neursteroid Modulatory Sites in GLIC: A Prototypic Pentameric Ligand Gated Ion Channel Biophysical Journal. 114: 299a. DOI: 10.1016/J.Bpj.2017.11.1704 |
0.226 |
|
| 2005 |
Kumar DM, Perez E, Cai ZY, Aoun P, Brun-Zinkernagel A, Covey DF, Simpkins JW, Agarwal N. Corrigendum to “Role of nonfeminizing estrogen analogues in neuroprotection of rat retinal ganglion cells against glutamate-induced cytotoxicity” [Free Radic. Biol. Med. 38:1152–1163; 2005] Free Radical Biology and Medicine. 39: 1676. DOI: 10.1016/J.Freeradbiomed.2005.09.009 |
0.225 |
|
| 2014 |
El Bitar F, Meunier J, Villard V, Alméras M, Krishnan K, Covey DF, Maurice T, Akwa Y. Neuroprotection by the synthetic neurosteroid enantiomers ent-PREGS and ent-DHEAS against Aβ₂₅₋₃₅ peptide-induced toxicity in vitro and in vivo in mice. Psychopharmacology. 231: 3293-312. PMID 24481566 DOI: 10.1007/S00213-014-3435-3 |
0.225 |
|
| 1995 |
Hu Y, Sherwin PF, Covey D. Erratum: Synthesis of (17R)- and (17S)- 17-hydroxy-14,15-secoandrost-4- en-15-yn-3-one and the X-ray crystal structure of the (17S)-diastereomer (Steroids (1995) 60 (250-255)) Steroids. 60. DOI: 10.1016/0039-128X(95)98213-J |
0.224 |
|
| 2006 |
Covey DF. Ent-steroids chemistry and biology Polish Journal of Chemistry. 80: 511-522. |
0.224 |
|
| 2009 |
Latham JR, Pathirathna S, Jagodic MM, Choe WJ, Levin ME, Nelson MT, Lee WY, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Selective T-type calcium channel blockade alleviates hyperalgesia in ob/ob mice. Diabetes. 58: 2656-65. PMID 19651818 DOI: 10.2337/Db08-1763 |
0.223 |
|
| 1984 |
Beusen DD, Covey DF. Study of the role of Schiff base formation in the aromatization of 3-[18O]testosterone and 3,17-di-[18O]androstenedione by human placental aromatase. Journal of Steroid Biochemistry. 20: 931-4. PMID 6708562 DOI: 10.1016/0022-4731(84)90408-4 |
0.222 |
|
| 2007 |
Shu HJ, Zeng CM, Wang C, Covey DF, Zorumski CF, Mennerick S. Cyclodextrins sequester neuroactive steroids and differentiate mechanisms that rate limit steroid actions. British Journal of Pharmacology. 150: 164-75. PMID 17160009 DOI: 10.1038/sj.bjp.0706973 |
0.22 |
|
| 2013 |
Maurice T, Akwa Y, Bitar FE, Meunier J, Villard V, Almeras M, Krishnan K, Covey D. Neuroprotection by the synthetic enantiomers of the neurosteroids PREGS and DHEAS against beta-amyloid 25-35 peptide–induced toxicity Alzheimers & Dementia. 9: 507. DOI: 10.1016/J.Jalz.2013.05.1059 |
0.22 |
|
| 2020 |
Timic Stamenic T, Feseha S, Manzella FM, Wallace D, Wilkey D, Corrigan T, Fiedler H, Doerr P, Krishnan K, Raol YH, Covey DF, Jevtovic-Todorovic V, Todorovic SM. The T-type calcium channel isoform Ca3.1 is a target for the hypnotic effect of the anaesthetic neurosteroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile. British Journal of Anaesthesia. PMID 32859366 DOI: 10.1016/J.Bja.2020.07.022 |
0.219 |
|
| 2001 |
Huang RQ, Bell-Horner CL, Dibas MI, Covey DF, Drewe JA, Dillon GH. Pentylenetetrazole-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action. The Journal of Pharmacology and Experimental Therapeutics. 298: 986-95. PMID 11504794 |
0.218 |
|
| 2020 |
Sugasawa Y, Cheng WW, Bracamontes JR, Chen ZW, Wang L, Germann AL, Pierce SR, Senneff TC, Krishnan K, Reichert DE, Covey DF, Akk G, Evers AS. Site-specific effects of neurosteroids on GABA receptor activation and desensitization. Elife. 9. PMID 32955433 DOI: 10.7554/Elife.55331 |
0.217 |
|
| 1990 |
Lawate SS, Covey DF. Trifluoromethylacetylenic alcohols as affinity labels: inactivation of estradiol dehydrogenase by a trifluoromethylacetylenic secostradiol. Journal of Medicinal Chemistry. 33: 2319-21. PMID 2391679 DOI: 10.1021/Jm00171A002 |
0.215 |
|
| 2020 |
Ziolkowski L, Mordukhovich I, Chen DM, Chisari M, Shu HJ, Lambert PM, Qian M, Zorumski CF, Covey DF, Mennerick S. A neuroactive steroid with a therapeutically interesting constellation of actions at GABA and NMDA receptors. Neuropharmacology. 108358. PMID 33115614 DOI: 10.1016/j.neuropharm.2020.108358 |
0.215 |
|
| 1996 |
Han M, Covey DF. An improved synthesis of 18-nor-17-ketosteroids and application of the method for the preparation of (3β,5β,13α)- and (3β,5β,13β)-3-hydroxygonan-17-one Journal of Organic Chemistry. 61: 7614-7616. DOI: 10.1021/Jo9611430 |
0.214 |
|
| 1996 |
Wittmer LL, Hu Y, Kalkbrenner M, Evers AS, Zorumski CF, Covey DF. Enantioselectivity of steroid-induced γ-aminobutyric acidA receptor modulation and anesthesia Molecular Pharmacology. 50: 1581-1586. PMID 8967980 |
0.213 |
|
| 1998 |
Todorovic SM, Covey DF, Lingle CJ. ENANTIOSELECTIVE BLOCKADE OF T-TYPE CALCIUM CURRENT IN RAT SENSORY NEURONS BY A NOVEL ANESTHETIC STEROID (+)-ACN Anesthesiology. 89: 156A. DOI: 10.1097/00000542-199809040-00060 |
0.212 |
|
| 1987 |
Heston WD, Watanabe KA, Pankiewicz KW, Covey DF. Cytotoxic and non-cytotoxic N-alkyl derivatives of putrescine: effect on polyamine uptake and growth of prostatic cancer cells in vitro. Biochemical Pharmacology. 36: 1849-52. PMID 3579979 DOI: 10.1016/0006-2952(87)90250-4 |
0.21 |
|
| 2006 |
Lancaster RW, Karamertzanis PG, Hulme AT, Tocher DA, Covey DF, Price SL. Racemic progesterone: predicted in silico and produced in the solid state. Chemical Communications (Cambridge, England). 4921-3. PMID 17136247 DOI: 10.1039/B611599C |
0.208 |
|
| 2009 |
Covey DF. ent-Steroids: novel tools for studies of signaling pathways. Steroids. 74: 577-85. PMID 19103212 DOI: 10.1016/j.steroids.2008.11.019 |
0.207 |
|
| 2001 |
Mennerick S, Zeng CM, Benz A, Shen W, Izumi Y, Evers AS, Covey DF, Zorumski CF. Effects on gamma-aminobutyric acid (GABA)(A) receptors of a neuroactive steroid that negatively modulates glutamate neurotransmission and augments GABA neurotransmission. Molecular Pharmacology. 60: 732-41. PMID 11562435 |
0.206 |
|
| 1999 |
Kumar AS, Covey DF. A new method for the preparation of Ent-cholesterol from Ent- testosterone Tetrahedron Letters. 40: 823-826. DOI: 10.1016/S0040-4039(98)02588-X |
0.204 |
|
| 2022 |
Shin HR, Citron YR, Wang L, Tribouillard L, Goul CS, Stipp R, Sugasawa Y, Jain A, Samson N, Lim CY, Davis OB, Castaneda-Carpio D, Qian M, Nomura DK, Perera RM, ... ... Covey DF, et al. Lysosomal GPCR-like protein LYCHOS signals cholesterol sufficiency to mTORC1. Science (New York, N.Y.). eabg6621. PMID 36007018 DOI: 10.1126/science.abg6621 |
0.201 |
|
| 2022 |
Dietzen NM, Arcario MJ, Chen LJ, Petroff JT, Moreland KT, Krishnan K, Brannigan G, Covey DF, Cheng WW. Polyunsaturated fatty acids inhibit a pentameric ligand-gated ion channel through one of two binding sites. Elife. 11. PMID 34982031 DOI: 10.7554/eLife.74306 |
0.201 |
|
| 2021 |
Wang L, Covey DF, Akk G, Evers AS. Neurosteroid modulation of GABAA receptor function by independent action at multiple specific binding sites. Current Neuropharmacology. PMID 34856904 DOI: 10.2174/1570159X19666211202150041 |
0.199 |
|
| 2023 |
Tateiwa H, Chintala SM, Chen Z, Wang L, Amtashar F, Bracamontes J, Germann AL, Pierce SR, Covey DF, Akk G, Evers AS. The Mechanism of Enantioselective Neurosteroid Actions on GABA Receptors. Biomolecules. 13. PMID 36830708 DOI: 10.3390/biom13020341 |
0.199 |
|
| 1998 |
Hill MW, Reddy PA, Covey DF, Rothman SM. Inhibition of voltage-dependent sodium channels by the anticonvulsant gamma-aminobutyric acid type A receptor modulator, 3-benzyl-3-ethyl-2-piperidinone. The Journal of Pharmacology and Experimental Therapeutics. 285: 1303-9. PMID 9618437 |
0.199 |
|
| 2018 |
Atluri N, Joksimovic SM, Oklopcic A, Milanovic D, Klawitter J, Eggan P, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. A neurosteroid analogue with T-type calcium channel blocking properties is an effective hypnotic, but is not harmful to neonatal rat brain. British Journal of Anaesthesia. 120: 768-778. PMID 29576117 DOI: 10.1016/J.Bja.2017.12.039 |
0.198 |
|
| 1993 |
Zimniski SJ, Brandt ME, Covey DF, Puett D. Inhibition of growth and appearance of estrogen-dependent rat mammary tumors by 10-propargylestr-4-ene-3,17-dione, an aromatase inhibitor. Breast Cancer Research and Treatment. 26: 15-21. PMID 8400320 DOI: 10.1007/Bf00682696 |
0.198 |
|
| 2021 |
Manzella FM, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future. Journal of Neuroendocrinology. e13086. PMID 35014105 DOI: 10.1111/jne.13086 |
0.198 |
|
| 2019 |
Chen ZW, Bracamontes JR, Budelier MM, Germann AL, Shin DJ, Kathiresan K, Qian MX, Manion B, Cheng WWL, Reichert DE, Akk G, Covey DF, Evers AS. Multiple functional neurosteroid binding sites on GABAA receptors. Plos Biology. 17: e3000157. PMID 30845142 DOI: 10.1371/Journal.Pbio.3000157 |
0.197 |
|
| 2013 |
Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Author response: Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Elife. DOI: 10.7554/Elife.01340.020 |
0.196 |
|
| 2021 |
Wagner AG, Stagnitta RT, Xu Z, Pezzullo JL, Kandel N, Giner JL, Covey DF, Wang C, Callahan BP. Nanomolar, Noncovalent Antagonism of Hedgehog Cholesterolysis: Exception to the "Irreversibility Rule" for Protein Autoprocessing Inhibition. Biochemistry. PMID 34941260 DOI: 10.1021/acs.biochem.1c00697 |
0.192 |
|
| 2005 |
Todorovic SM, Covey DF, Zorumski CF, Jevtovic-Todorovic V. Neuroactive steroids as targets for development of novel pain therapies Current Medicinal Chemistry - Central Nervous System Agents. 5: 157-164. DOI: 10.2174/1568015054022407 |
0.192 |
|
| 2001 |
Lalitha S, Kumar AS, Stine KJ, Covey DF. Enantiospecificity of sterol-lipid interactions: First evidence that the absolute configuration of cholesterol affects the physical properties of cholesterol-sphingomyelin membranes Chemical Communications. 1192-1193. |
0.191 |
|
| 2021 |
Griffiths SC, Schwab RA, El Omari K, Bishop B, Iverson EJ, Malinauskas T, Dubey R, Qian M, Covey DF, Gilbert RJC, Rohatgi R, Siebold C. Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nature Communications. 12: 7171. PMID 34887403 DOI: 10.1038/s41467-021-27475-2 |
0.19 |
|
| 2020 |
Szomek M, Moesgaard L, Reinholdt P, Haarhøj Hald SB, Petersen D, Krishnan K, Covey DF, Kongsted J, Wüstner D. Membrane organization and intracellular transport of a fluorescent analogue of 27-hydroxycholesterol. Chemistry and Physics of Lipids. 233: 105004. PMID 33137329 DOI: 10.1016/j.chemphyslip.2020.105004 |
0.186 |
|
| 2021 |
Moldavski O, Zushin PH, Berdan CA, Van Eijkeren RJ, Jiang X, Qian M, Ory DS, Covey DF, Nomura DK, Stahl A, Weiss EJ, Zoncu R. 4β-hydroxycholesterol is a pro-lipogenic factor that promotes SREBP1c expression and activity through Liver X-receptor. Journal of Lipid Research. 100051. PMID 33631213 DOI: 10.1016/j.jlr.2021.100051 |
0.182 |
|
| 2022 |
Kinnebrew M, Woolley RE, Ansell TB, Byrne EFX, Frigui S, Luchetti G, Sircar R, Nachtergaele S, Mydock-McGrane L, Krishnan K, Newstead S, Sansom MSP, Covey DF, Siebold C, Rohatgi R. Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Science Advances. 8: eabm5563. PMID 35658032 DOI: 10.1126/sciadv.abm5563 |
0.179 |
|
| 2023 |
Akkerman V, Scheidt HA, Reinholdt P, Bashawat M, Szomek M, Lehmann M, Wessig P, Covey DF, Kongsted J, Müller P, Wüstner D. Natamycin interferes with ergosterol-dependent lipid phases in model membranes. Bba Advances. 4: 100102. PMID 37691996 DOI: 10.1016/j.bbadva.2023.100102 |
0.179 |
|
| 2018 |
Chen DM, Ziolkowski L, Benz A, Qian M, Zorumski CF, Covey DF, Mennerick S. A Clickable Oxysterol Photolabel Retains NMDA Receptor Activity and Accumulates in Neurons. Frontiers in Neuroscience. 12: 923. PMID 30574068 DOI: 10.3389/fnins.2018.00923 |
0.175 |
|
| 2024 |
Germann AL, Xu Y, Covey DF, Evers AS, Akk G. Comparison of Behavioral Effects of GABAergic Low- and High-Efficacy Neuroactive Steroids in the Zebrafish Larvae Assay. Acs Chemical Neuroscience. PMID 38386612 DOI: 10.1021/acschemneuro.3c00836 |
0.172 |
|
| 1995 |
Hu Y, Zorumski CF, Covey DF. Neurosteroid analogues. 2. Total synthesis and electrophysiological evaluation of benz[e]indene analogues of the anesthetic steroid alphaxalone Journal of Organic Chemistry. 60: 3619-3625. |
0.167 |
|
| 2024 |
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter JF, et al. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Nature Structural & Molecular Biology. PMID 38326651 DOI: 10.1038/s41594-024-01223-8 |
0.155 |
|
| 2023 |
Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, et al. GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway. Biorxiv : the Preprint Server For Biology. PMID 37292845 DOI: 10.1101/2023.05.23.540554 |
0.154 |
|
| 2021 |
Juhl AD, Heegaard CW, Werner S, Schneider G, Krishnan K, Covey DF, Wüstner D. Quantitative imaging of membrane contact sites for sterol transfer between endo-lysosomes and mitochondria in living cells. Scientific Reports. 11: 8927. PMID 33903617 DOI: 10.1038/s41598-021-87876-7 |
0.152 |
|
| 2023 |
Covey DF, Evers AS, Izumi Y, Maguire JL, Mennerick SJ, Zorumski CF. Neurosteroid Enantiomers as Potentially Novel Neurotherapeutics. Neuroscience and Biobehavioral Reviews. 105191. PMID 37085023 DOI: 10.1016/j.neubiorev.2023.105191 |
0.151 |
|
| 2024 |
Freitas FP, Alborzinia H, Dos Santos AF, Nepachalovich P, Pedrera L, Zilka O, Inague A, Klein C, Aroua N, Kaushal K, Kast B, Lorenz SM, Kunz V, Nehring H, Xavier da Silva TN, ... ... Covey DF, et al. 7-Dehydrocholesterol is an endogenous suppressor of ferroptosis. Nature. PMID 38297129 DOI: 10.1038/s41586-023-06878-9 |
0.149 |
|
| 2013 |
Nachtergaele S, Whalen DM, Mydock LK, Zhao Z, Malinauskas T, Krishnan K, Ingham PW, Covey DF, Siebold C, Rohatgi R. Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling Elife. 2013. DOI: 10.7554/eLife.01340.001 |
0.147 |
|
| 2000 |
Shen W, Mennerick S, Covey DF, Zorumski CF. Pregnenolone sulfate modulates inhibitory synaptic transmission by enhancing GABA(A) receptor desensitization. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3571-9. PMID 10804198 |
0.147 |
|
| 2011 |
Yuan C, Chen M, Covey DF, Johnston LJ, Treistman SN. Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids. Plos One. 6: e27572. PMID 22140451 DOI: 10.1371/journal.pone.0027572 |
0.146 |
|
| 2000 |
Zorumski CF, Mennerick S, Isenberg KE, Covey DF. Potential clinical uses of neuroactive steroids. Idrugs : the Investigational Drugs Journal. 3: 1053-63. PMID 16049865 |
0.145 |
|
| 2000 |
Zorumski CF, Mennerick S, Isenberg KE, Covey DF. Potential clinical uses of neuroactive steroids. Current Opinion in Investigational Drugs (London, England : 2000). 1: 360-9. PMID 11249720 |
0.145 |
|
| 2022 |
Ishikawa M, Nakazawa T, Kunikata H, Sato K, Yoshitomi T, Krishnan K, Covey DF, Zorumski CF, Izumi Y. The Enantiomer of Allopregnanolone Prevents Pressure-Mediated Retinal Degeneration Via Autophagy. Frontiers in Pharmacology. 13: 855779. PMID 35370641 DOI: 10.3389/fphar.2022.855779 |
0.143 |
|
| 2010 |
TINAO-WOOLDRIDGE LV, HSIANG BCH, LATIFI TN, FERRENDELLI JA, COVEY DF. ChemInform Abstract: Partial Structures of the Fungal Toxin Aflatrem, Methyl-Substituted 6, 8-Dioxabicyclo(3.2.1)octan-2-ones Having Anticonvulsant Activity. Cheminform. 26: no-no. DOI: 10.1002/chin.199527266 |
0.136 |
|
| 1997 |
Gross RA, Covey DF, Ferrendelli JA. Voltage-dependent calcium channels as targets for convulsant and anticonvulsant alkyl-substituted thiobutyrolactones. The Journal of Pharmacology and Experimental Therapeutics. 280: 686-94. PMID 9023280 |
0.135 |
|
| 1997 |
Hu Y, Wittmer LL, Kalkbrenner M, Evers AS, Zorumski CF, Covey DF. Neurosteroid analogues. Part 5. Enantiomers of neuroactive steroids and benz[e]indenes: Total synthesis, electrophysiological effects on GABAA receptor function and anesthetic actions in tadpoles Journal of the Chemical Society - Perkin Transactions 1. 3665-3671. |
0.133 |
|
| 2023 |
Qian M, Xu Y, Covey DF. Synthetic routes to trifluoromethylphenyl diazirine photolabeling reagents containing an alkyne substituent (TPDYNE) for chemical biology applications. Rsc Advances. 13: 36484-36492. PMID 38099258 DOI: 10.1039/d3ra07260f |
0.133 |
|
| 2022 |
Izumi Y, Ishikawa M, Nakazawa T, Kunikata H, Sato K, Covey DF, Zorumski CF. Neurosteroids as stress modulators and neurotherapeutics: lessons from the retina. Neural Regeneration Research. 18: 1004-1008. PMID 36254981 DOI: 10.4103/1673-5374.355752 |
0.131 |
|
| 2021 |
Coulter I, Stamenic TT, Eggan P, Fine BR, Corrigan T, Covey DF, Yang L, Pan JQ, Todorovic SM. Different roles of T-type calcium channel isoforms in hypnosis induced by an endogenous neurosteroid epipregnanolone. Neuropharmacology. 108739. PMID 34339750 DOI: 10.1016/j.neuropharm.2021.108739 |
0.13 |
|
| 1983 |
COVEY DF, PARIKH VD. ChemInform Abstract: INHIBITORS OF STEROID BIOSYNTHESIS: PREPARATION OF 5,10-SECOESTR-4-YNES Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198321311 |
0.125 |
|
| 2024 |
Qian M, Covey DF. A unified total synthesis route to 18-trideuterated and/or 19-trideuterated testosterone, androstenedione and progesterone. Steroids. 205: 109391. PMID 38437943 DOI: 10.1016/j.steroids.2024.109391 |
0.12 |
|
| 1990 |
Holland K, Ferrendelli J, Covey D, Rothman S. Physiological regulation of the picrotoxin receptor by gamma- butyrolactones and gamma-thiobutyrolactones in cultured hippocampal neurons The Journal of Neuroscience. 10: 1719-1727. DOI: 10.1523/jneurosci.10-06-01719.1990 |
0.119 |
|
| 1987 |
AUCHUS RJ, COVEY DF. ChemInform Abstract: Dehydrogenase Inactivation by an Enzyme-Generated Acetylenic Ketone: Identification of a Lysyl Enaminone by 13C NMR. Cheminform. 18. DOI: 10.1002/chin.198721268 |
0.117 |
|
| 2024 |
Salvatore SV, Ilagan MXG, Shu H, Lambert PM, Benz A, Qian M, Covey DF, Zorumski CF, Mennerick S. Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model. Scientific Reports. 14: 1042. PMID 38200205 DOI: 10.1038/s41598-024-51582-x |
0.116 |
|
| 2010 |
HAN M, HU Y, ZORUMSKI CF, COVEY DF. ChemInform Abstract: Neurosteroid Analogues. Part 3. The Synthesis and Electrophysiological Evaluation of Benz(e)indene Congeners of Neuroactive Steroids Having the 5β-Configuration. Cheminform. 27: no-no. DOI: 10.1002/chin.199610259 |
0.114 |
|
| 2010 |
Zeng C, Han M, Covey DF. ChemInform Abstract: Neurosteroid Analogues. Part 7. A Synthetic Route for the Conversion of 5β-Methyl-3-ketosteroids into 7(S)-Methyl-Substituted Analogues of Neuroactive Benz[e]indenes. Cheminform. 31: no-no. DOI: 10.1002/chin.200029153 |
0.113 |
|
| 1977 |
COVEY DF, NICKON A. ChemInform Abstract: DIFUNCTIONALIZED BRENDANES VIA THALLIUM TRIACETATE CLEAVAGE OF THE CYCLOPROPYL RING OF TRIAXANE Chemischer Informationsdienst. 8: no-no. DOI: 10.1002/chin.197725187 |
0.107 |
|
| 2018 |
Ishikawa M, Yoshitomi T, Covey DF, Zorumski CF, Izumi Y. Neurosteroids and oxysterols as potential therapeutic agents for glaucoma and Alzheimer's disease. Neuropsychiatry. 8: 344-359. PMID 30774720 DOI: 10.4172/Neuropsychiatry.1000356 |
0.106 |
|
| 2022 |
Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. British Journal of Anaesthesia. PMID 36428160 DOI: 10.1016/j.bja.2022.09.025 |
0.106 |
|
| 2000 |
Covey DF, et al. ea. ChemInform Abstract: Neurosteroid Analogues. Part 8. Structure-Activity Studies of N-Acylated 17a-Aza-D-homosteroid Analogues of the Anesthetic Steroids (3α,5α)- and (3α,5β)-3-Hydroxypregnan-20-one. Cheminform. 31: no-no. DOI: 10.1002/chin.200050195 |
0.102 |
|
| 2010 |
HU Y, COVEY DF. ChemInform Abstract: Synthesis of 1,10-Seco-5α-estr-1-ynes: Potential Mechanism-Based Inhibitors of 3α- and 3β-Hydroxysteroid Dehydrogenases. Cheminform. 24: no-no. DOI: 10.1002/chin.199323253 |
0.101 |
|
| 1987 |
LEVINE JA, FERRENDELLI JA, COVEY DF. ChemInform Abstract: Alkyl-Substituted Thiolo-, Thiono-, and Dithio-γ-butyrolactones: New Classes of Convulsant and Anticonvulsant Agents. Cheminform. 18. DOI: 10.1002/chin.198711161 |
0.097 |
|
| 2000 |
Abel E, De Wall SL, Edwards WB, Lalitha S, Covey DF, Gokel GW. Aggregate formation from 3-alkylindoles: Amphiphilic models for interfacial helix anchoring groups Chemical Communications. 433-434. |
0.097 |
|
| 2020 |
Tat QL, Joksimovic SM, Krishnan K, Covey DF, Todorovic SM, Jevtovic-Todorovic V. Preemptive Analgesic Effect of Intrathecal Applications of Neuroactive Steroids in a Rodent Model of Post-Surgical Pain: Evidence for the Role of T-Type Calcium Channels. Cells. 9. PMID 33322727 DOI: 10.3390/cells9122674 |
0.097 |
|
| 1983 |
KLUNK WE, MCKEON AC, COVEY DF, FERRENDELLI JA. ChemInform Abstract: ALPHA-SUBSTITUTED Γ-BUTYROLACTONES: NEW CLASS OF ANTICONVULSANT DRUGS Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198310211 |
0.095 |
|
| 2022 |
Timic Stamenic T, Manzella FM, Maksimovic S, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Further Evidence that Inhibition of Neuronal Voltage-Gated Calcium Channels Contributes to the Hypnotic Effect of Neurosteroid Analogue, 3β-OH. Frontiers in Pharmacology. 13: 850658. PMID 35677453 DOI: 10.3389/fphar.2022.850658 |
0.094 |
|
| 2014 |
Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology. 231: 3503-15. PMID 24800894 DOI: 10.1007/S00213-014-3588-0 |
0.086 |
|
| 2002 |
Wang M, He Y, Eisenman LN, Fields C, Zeng C, Mathews J, Benz A, Fu T, Zorumski E, Steinbach JH, Covey DF, Zorumski CF, Mennerick S. 3β-Hydroxypregnane Steroids Are Pregnenolone Sulfate-Like GABAAReceptor Antagonists The Journal of Neuroscience. 22: 3366-3375. DOI: 10.1523/JNEUROSCI.22-09-03366.2002 |
0.085 |
|
| 2021 |
Izumi Y, Cashikar A, Krishnan K, Paul SM, Covey DF, Mennerick SJ, Zorumski CF. A Pro-inflammatory Stimulus Disrupts Hippocampal Plasticity and Learning via Microglial Activation and 25-Hydroxycholesterol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 34725187 DOI: 10.1523/JNEUROSCI.1502-21.2021 |
0.084 |
|
| 1979 |
COVEY DF, PARIKH VD, CHIEN WW. ChemInform Abstract: 19-ACETYLENIC, 19-HYDROXYANDROST-4-ENE-3,17-DIONES. POTENTIAL SUICIDE SUBSTRATES OF ESTROGEN BIOSYNTHESIS Chemischer Informationsdienst. 10. DOI: 10.1002/chin.197939285 |
0.081 |
|
| 2013 |
Orestes P, Osuru HP, McIntire WE, Jacus MO, Salajegheh R, Jagodic MM, Choe W, Lee J, Lee SS, Rose KE, Poiro N, Digruccio MR, Krishnan K, Covey DF, Lee JH, et al. Reversal of neuropathic pain in diabetes by targeting glycosylation of Ca(V)3.2 T-type calcium channels. Diabetes. 62: 3828-38. PMID 23835327 DOI: 10.2337/Db13-0813 |
0.075 |
|
| 2019 |
Han M, Covey DF. An Improved Synthesis of 18-Nor-17-ketosteroids and Application of the Method for the Preparation of (3beta,5beta,13alpha)- and (3beta,5beta,13beta)-3-Hydroxygonan-17-one. The Journal of Organic Chemistry. 61: 7614-7616. PMID 11667699 DOI: 10.1021/jo9611430 |
0.07 |
|
| 2010 |
PETERSON EM, XU K, HOLLAND KD, MCKEON AC, ROTHMAN SM, FERRENDELLI JA, COVEY DF. ChemInform Abstract: α-Spirocyclopentyl- and α-Spirocyclopropyl-γ- butyrolactones: Conformationally Constrained Derivatives of Anticonvulsant and Convulsant α,α-Disubstituted γ- Butyrolactones. Cheminform. 25: no-no. DOI: 10.1002/chin.199420140 |
0.068 |
|
| 2001 |
Green PS, Yang SH, Nilsson KR, Kumar AS, Covey DF, Simpkins JW. The nonfeminizing enantiomer of 17β-estradiol exerts protective effects in neuronal cultures and a rat model of cerebral ischemia Endocrinology. 142: 400-406. DOI: 10.1210/en.142.1.400 |
0.064 |
|
| 2000 |
Ellis SL, Carter BL, Malone DC, Billups SJ, Okano GJ, Valuck RJ, Barnette DJ, Sintek CD, Covey D, Mason B, Jue S, Carmichael J, Guthrie K, Dombrowski R, Geraets DR, et al. Clinical and economic impact of ambulatory care clinical pharmacists in management of dyslipidemia in older adults: the IMPROVE study. Impact of Managed Pharmaceutical Care on Resource Utilization and Outcomes in Veterans Affairs Medical Centers. Pharmacotherapy. 20: 1508-16. PMID 11130223 DOI: 10.1592/Phco.20.19.1508.34852 |
0.064 |
|
| 2023 |
Fine-Raquet B, Manzella FM, Joksimovic SM, Dietz RM, Orfila JE, Sampath D, Tesic V, Atluri N, Covey DF, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum. Experimental Biology and Medicine (Maywood, N.J.). 15353702231177009. PMID 37309730 DOI: 10.1177/15353702231177009 |
0.063 |
|
| 2000 |
Abel E, De Wall SL, Edwards WB, Lalitha S, Covey DF, Gokel GW. Formation of stable vesicles from N- or 3-alkylindoles: possible evidence for tryptophan as a membrane anchor in proteins. The Journal of Organic Chemistry. 65: 5901-9. PMID 10987920 DOI: 10.1021/Jo000040L |
0.063 |
|
| 2021 |
Joksimovic SM, Sampath D, Krishnan K, Covey DF, Jevtovic-Todorovic V, Raol YH, Todorovic SM. Differential effects of the novel neurosteroid hypnotic (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile on electroencephalogram activity in male and female rats. British Journal of Anaesthesia. PMID 33972091 DOI: 10.1016/j.bja.2021.03.029 |
0.061 |
|
| 2010 |
HAN M, COVEY DF. ChemInform Abstract: An Improved Synthesis of 18-Nor-17-ketosteroids and Application of the Method for the Preparation of (3β,5β,13α)- and (3β ,5β,13β)-3-Hydroxygonan-17-one. Cheminform. 28: no-no. DOI: 10.1002/chin.199710158 |
0.06 |
|
| 2022 |
Maksimovic S, Useinovic N, Quillinan N, Covey DF, Todorovic SM, Jevtovic-Todorovic V. General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action. International Journal of Molecular Sciences. 23. PMID 35163810 DOI: 10.3390/ijms23031889 |
0.06 |
|
| 1992 |
Bernard JM, Black JR, Kokseng CU, Covey DF. Warfarin sodium. Practitioner beware Journal of the American Podiatric Medical Association. 82: 345-351. PMID 1432651 DOI: 10.7547/87507315-82-7-345 |
0.056 |
|
| 1988 |
Eckert RJA, Covey DF. Developments in the field of hydrogenated diene copolymers as viscosity index improvers Lubrication Science. 1: 65-80. DOI: 10.1002/ls.3010010106 |
0.045 |
|
| 2017 |
Lee M, Badowski ME, Acquisto NM, Covey DF, Fox BD, Gaffney SM, Haines ST, Hilaire ML, Raymond A, Salvo MC, Turner K. ACCP Template for Evaluating a Clinical Pharmacist. Pharmacotherapy. PMID 28417479 DOI: 10.1002/phar.1927 |
0.018 |
|
| 1975 |
Thorburn Burns D, Covey D, Johnson E. Identification and determination of certain N,N′-disubstituted p-phenylenediamine antiozonants in cured styrenebutadiene elastomers Journal of Chromatography A. 103: 247-258. DOI: 10.1016/S0021-9673(00)87217-9 |
0.015 |
|
| 2016 |
Sorensen TD, Shapiro NL, Benedict N, Edwards KL, Chan A, Covey D, Daniels C, Hagemann T, Hemstreet B, Miller W, Musselman ME. Recommendations for Aligning PGY2 Pharmacy Residency Training and Pharmacy Specialist Board Certification. Pharmacotherapy. PMID 27062513 DOI: 10.1002/phar.1741 |
0.01 |
|
| 1998 |
Bauman JL, Boucher BA, Bosso JA, Burckart GJ, Bussey HI, Chatto K, Covey DF, Cramer WR, Dasta JF, DeVane CL, Dukes GE, Elenbaas RM, Fagan SC, Garnett WR, Geraets DR, et al. The strategic plan of the American College of Clinical Pharmacy 1998- 2000 Pharmacotherapy. 18: 417-424. PMID 9545166 |
0.01 |
|
| 1992 |
Covey DF, Shackelford DD, Geck WE. Pharmacy Services in a Hypertension Clinic Journal of Pharmacy Practice. 5: 7-11. DOI: 10.1177/089719009200500104 |
0.01 |
|
| Hide low-probability matches. |