Kuo-Hsiung Lee - Publications

Affiliations: 
Pharmaceutical Sciences University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmaceutical Chemistry, Pharmacology

280 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Tsurumi F, Miura Y, Nakano M, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from . Journal of Natural Products. PMID 31442048 DOI: 10.1021/acs.jnatprod.8b00732  0.52
2019 Chang YT, Teng YN, Lin KI, Wang CCN, Morris-Natschke SL, Lee KH, Hung CC. Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells. Scientific Reports. 9: 11628. PMID 31406162 DOI: 10.1038/s41598-019-48169-2  0.8
2019 Luo M, Zhang JC, Yin H, Wang CM, Morris-Natschke S, Lee KH. Correction to: One-step templated synthesis of chiral organometallic salicyloxazoline complexes. Bmc Chemistry. 13: 63. PMID 31386026 DOI: 10.1186/s13065-019-0577-8  0.48
2019 Luo M, Zhang JC, Yin H, Wang CM, Morris-Natschke S, Lee KH. One-step templated synthesis of chiral organometallic salicyloxazoline complexes. Bmc Chemistry. 13: 51. PMID 31384799 DOI: 10.1186/s13065-019-0565-z  0.48
2019 Yamashita H, Matsuzaki M, Kurokawa Y, Nakane T, Goto M, Lee KH, Shibata T, Bando H, Wada K. Four New Triterpenoids from the Bark of forma . Phytochemistry Letters. 31: 140-146. PMID 31379978 DOI: 10.1016/j.phytol.2019.03.015  0.48
2019 Yamashita H, Miyao M, Hiramori K, Kobayashi D, Suzuki Y, Mizukami M, Goto M, Lee KH, Wada K. Cytotoxic diterpenoid alkaloid from Aconitum japonicum subsp. subcuneatum. Journal of Natural Medicines. PMID 31346973 DOI: 10.1007/s11418-019-01346-z  0.48
2019 Liu Q, Cheng YY, Li W, Huang L, Asada Y, Hsieh MT, Morris-Natschke SL, Chen CH, Koike K, Lee KH. Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents. Journal of Medicinal Chemistry. PMID 31343875 DOI: 10.1021/acs.jmedchem.9b00339  0.8
2019 Wada K, Goto M, Shimizu T, Kusanagi N, Mizukami M, Suzuki Y, Li KP, Lee KH, Yamashita H. Structure-activity relationships and evaluation of esterified diterpenoid alkaloid derivatives as antiproliferative agents. Journal of Natural Medicines. PMID 31222559 DOI: 10.1007/s11418-019-01331-6  0.48
2019 Zhou KS, Yi P, Yang T, Tian W, Yang FM, Lee KH, Zhao BY, Wang YH, Tan CJ. Ochrocephalamines B-D, Three Alkaloids from Oxytropis ochrocephala Bunge. Organic Letters. PMID 31199154 DOI: 10.1021/acs.orglett.9b01643  0.48
2019 Wang GK, Jin WF, Zhang N, Wang G, Cheng YY, Morris-Natschke SL, Goto M, Zhou ZY, Liu JS, Lee KH. Kalshiolin A, new lignan from . Journal of Asian Natural Products Research. 1-7. PMID 31190564 DOI: 10.1080/10286020.2019.1592164  0.8
2019 Huang YS, Lu Y, Chen CH, Lee KH, Chen DF. Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata. Journal of Natural Products. PMID 31184480 DOI: 10.1021/acs.jnatprod.9b00088  0.8
2019 Li J, Chang LC, Hsieh KY, Hsu PL, Capuzzi SJ, Zhang YC, Li KP, Morris-Natschke SL, Goto M, Lee KH. Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid. Bioorganic & Medicinal Chemistry. PMID 31126820 DOI: 10.1016/j.bmc.2019.05.016  0.8
2019 Chen PY, Chang CC, Huang HC, Zhang LJ, Liaw CC, Lin YC, Nguyen NL, Vo TH, Cheng YY, Morris-Natschke SL, Lee KH, Kuo YH. New Dammarane-type Saponins from . Molecules (Basel, Switzerland). 24. PMID 30965662 DOI: 10.3390/molecules24071375  0.8
2019 Zhang Y, Goto M, Oda A, Hsu PL, Guo LL, Fu YH, Morris-Natschke SL, Hamel E, Lee KH, Hao XJ. Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Inhibit Tubulin Polymerization. Molecules (Basel, Switzerland). 24. PMID 30935100 DOI: 10.3390/molecules24071256  0.8
2019 Song ZL, Yang GZ, Li JC, Liu YQ, Yang CJ, Goto M, Zhang ZJ, Morris-Natschke SL, Liu H, Lee KH. Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents. Natural Product Research. 1-8. PMID 30784310 DOI: 10.1080/14786419.2019.1573231  0.8
2019 Wu H, Ma G, Yang Q, Zhu Y, Huang L, Tian Y, Yang X, Zhang M, Chen CH, Morris-Natschke SL, Yang M, Xu X, Lee KH. Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity. European Journal of Medicinal Chemistry. 166: 159-166. PMID 30703659 DOI: 10.1016/j.ejmech.2019.01.020  0.8
2019 Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, et al. Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. Journal of Medicinal Chemistry. PMID 30624934 DOI: 10.1021/acs.jmedchem.8b01656  0.8
2018 Chang YT, Wang CCN, Wang JY, Lee TE, Cheng YY, Morris-Natschke SL, Lee KH, Hung CC. Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 53: 252-262. PMID 30668405 DOI: 10.1016/j.phymed.2018.09.008  0.8
2018 Gao P, Wang X, Sun L, Cheng X, Poongavanam V, Kongsted J, Álvarez M, Luczkowiak J, Pannecouque C, Clercq E, Lee KH, Chen CH, Liu H, Menéndez-Arias L, Liu X, et al. Design, Synthesis and Biological Evaluation of Novel Galloyl Derivatives as HIV-1 RNase H Inhibitors. Chemical Biology & Drug Design. PMID 30560566 DOI: 10.1111/cbdd.13455  0.8
2018 Guo Y, Wang K, Chen X, Li H, Wan Q, Morris-Natschke S, Lee KH, Chen Y. Seco-4-methyl-DCK derivatives as potent chemosensitizers. Bioorganic & Medicinal Chemistry Letters. PMID 30455148 DOI: 10.1016/j.bmcl.2018.11.023  0.48
2018 Zhao YF, Zhang YW, Wang Y, Morris-Natschke SL, Liu W, Shang TT, Yin H, Lee KH, Huang XF. New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III. Natural Product Research. 1-7. PMID 30453752 DOI: 10.1080/14786419.2018.1499640  0.8
2018 Wu G, Zalloum WA, Meuser ME, Jing L, Kang D, Chen CH, Tian Y, Zhang F, Cocklin S, Lee KH, Liu X, Zhan P. Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. European Journal of Medicinal Chemistry. 158: 478-492. PMID 30243152 DOI: 10.1016/j.ejmech.2018.09.029  0.8
2018 Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. Journal of Natural Products. PMID 30106296 DOI: 10.1021/acs.jnatprod.8b00411  0.52
2018 Liu Q, Li W, Huang L, Asada Y, Morris-Natschke SL, Chen CH, Lee KH, Koike K. Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui. European Journal of Medicinal Chemistry. 156: 618-627. PMID 30031972 DOI: 10.1016/j.ejmech.2018.07.020  0.8
2018 Rahim A, Saito Y, Miyake K, Goto M, Chen CH, Alam G, Morris-Natschke S, Lee KH, Nakagawa-Goto K. Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita. Journal of Natural Products. PMID 30010341 DOI: 10.1021/acs.jnatprod.8b00211  0.8
2018 Zhang Q, Hu XF, Xin MM, Liu HB, Sun LJ, Morris-Natschke SL, Chen Y, Lee KH. Antidiabetic potential of the ethyl acetate extract of Physalis alkekengi and chemical constituents identified by HPLC-ESI-QTOF-MS. Journal of Ethnopharmacology. PMID 29981847 DOI: 10.1016/j.jep.2018.07.007  0.8
2018 Sun YP, Jin WF, Wang YY, Wang G, Morris-Natschke SL, Liu JS, Wang GK, Lee KH. Chemical Structures and Biological Activities of Limonoids from the Genus (Meliaceae). Molecules (Basel, Switzerland). 23. PMID 29966275 DOI: 10.3390/molecules23071588  0.8
2018 Hsieh MT, Huang LJ, Wu TS, Lin HY, Morris-Natschke SL, Lee KH, Kuo SC. Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells. Bioorganic & Medicinal Chemistry. PMID 29908756 DOI: 10.1016/j.bmc.2018.06.011  0.8
2018 Ling Y, Yang QX, Teng YN, Chen S, Gao WJ, Guo J, Hsu PL, Liu Y, Morris-Natschke SL, Hung CC, Lee KH. Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities. European Journal of Medicinal Chemistry. 154: 199-209. PMID 29803003 DOI: 10.1016/j.ejmech.2018.05.025  0.8
2018 Jing L, Tang Y, Goto M, Lee KH, Xiao Z. SAR study on ,-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents. Rsc Advances. 8: 11871-11885. PMID 29682280 DOI: 10.1039/c8ra01440j  0.68
2018 Tian Y, Liu Z, Liu J, Huang B, Kang D, Zhang H, De Clercq E, Daelemans D, Pannecouque C, Lee KH, Chen CH, Zhan P, Liu X. Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus. European Journal of Medicinal Chemistry. 151: 339-350. PMID 29635166 DOI: 10.1016/j.ejmech.2018.03.059  0.8
2018 Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata. Organic Letters. PMID 29624062 DOI: 10.1021/acs.orglett.8b00624  0.52
2018 Huang L, Lai WH, Zhu L, Li W, Wei L, Lee KH, Xie L, Chen CH. Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor. Acs Medicinal Chemistry Letters. 9: 268-273. PMID 29541372 DOI: 10.1021/acsmedchemlett.8b00012  0.8
2018 Teng YN, Wang Y, Hsu PL, Xin G, Zhang Y, Morris-Natschke SL, Goto M, Lee KH. Mechanism of action of cytotoxic compounds from the seeds of Euphorbia lathyris. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 41: 62-66. PMID 29519320 DOI: 10.1016/j.phymed.2018.02.001  0.8
2018 Shang XF, Morris-Natschke SL, Yang GZ, Liu YQ, Guo X, Xu XS, Goto M, Li JC, Zhang JY, Lee KH. Biologically active quinoline and quinazoline alkaloids part II. Medicinal Research Reviews. PMID 29485730 DOI: 10.1002/med.21492  0.8
2018 Wang YR, Yu Y, Li SM, Liu W, Li W, Morris-Natschke SL, Goto M, Lee KH, Huang XF. Salvisertin A, a New Hexacyclic Triterpenoid, and Other Bioactive Terpenes from Salvia deserta Root. Chemistry & Biodiversity. PMID 29451710 DOI: 10.1002/cbdv.201800019  0.8
2018 Hu XF, Zhang Q, Zhang PP, Sun LJ, Liang JC, Morris-Natschke SL, Chen Y, Lee KH. Evaluation of in vitro/in vivo anti-diabetic effects and identification of compounds from Physalis alkekengi. Fitoterapia. PMID 29447981 DOI: 10.1016/j.fitote.2018.02.015  0.8
2018 Yamashita H, Katoh M, Kokubun A, Uchimura A, Mikami S, Takeuchi A, Kaneda K, Suzuki Y, Mizukami M, Goto M, Lee KH, Wada K. Four new C19-diterpenoid alkaloids from Delphinium elatum. Phytochemistry Letters. 24: 6-9. PMID 29375725 DOI: 10.1016/j.phytol.2017.12.013  0.48
2018 Zhang Y, Yuan YX, Goto M, Guo LL, Li XN, Morris-Natschke SL, Lee KH, Hao XJ. Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa. Journal of Natural Products. PMID 29319316 DOI: 10.1021/acs.jnatprod.7b00949  0.8
2017 Zhao Y, Liu PY, Hsieh KY, Hsu PL, Goto M, Morris-Natschke SL, Harn HJ, Lee KH. Design, Synthesis and Structure-Activity Relationships of (±)-Isochaihulactone Derivatives. Medchemcomm. 8: 2040-2049. PMID 29391939 DOI: 10.1039/C7MD00310B  0.8
2017 Wang Y, Chen SR, Yang X, Lee KH, Cheng YC. Structure-activity relationships of cryptopleurine analogs with E-ring modifications as anti-hepatitis C virus agents. Bioorganic & Medicinal Chemistry. PMID 29317151 DOI: 10.1016/j.bmc.2017.12.027  0.64
2017 Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa. The Journal of Organic Chemistry. PMID 29286245 DOI: 10.1021/acs.joc.7b02951  0.52
2017 Yang X, Zhao Y, Hsieh MT, Xin G, Wu RT, Hsu PL, Horng LY, Sung HC, Cheng CH, Lee KH. Total Synthesis of (+)-Medicarpin. Journal of Natural Products. PMID 29164880 DOI: 10.1021/acs.jnatprod.7b00741  0.48
2017 Chang LC, Hsieh MT, Yang JS, Lu CC, Tsai FJ, Tsao JW, Chiu YJ, Kuo SC, Lee KH. Effect of bis(hydroxymethyl) alkanoate curcuminoid derivative MTH-3 on cell cycle arrest, apoptotic and autophagic pathway in triple-negative breast adenocarcinoma MDA-MB-231 cells: An in vitro study. International Journal of Oncology. PMID 29138806 DOI: 10.3892/ijo.2017.4204  0.44
2017 Chen Z, Duan H, Tong X, Hsu P, Han L, Morris-Natschke SL, Yang S, Liu W, Lee KH. Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives. Journal of Natural Products. PMID 29131631 DOI: 10.1021/acs.jnatprod.7b00578  0.8
2017 Yamashita H, Takeda K, Haraguchi M, Abe Y, Kuwahara N, Suzuki S, Terui A, Masaka T, Munakata N, Uchida M, Nunokawa M, Kaneda K, Goto M, Lee KH, Wada K. Four new diterpenoid alkaloids from Aconitum japonicum subsp. subcuneatum. Journal of Natural Medicines. PMID 29052027 DOI: 10.1007/s11418-017-1139-9  0.48
2017 Yang CJ, Song ZL, Goto M, Hsu PL, Zhang XS, Yang QR, Liu YQ, Wang MJ, Morris-Natschke SL, Shang XF, Lee KH. Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 28927790 DOI: 10.1016/j.bmcl.2017.09.012  0.8
2017 Shiau JY, Nakagawa-Goto K, Lee KH, Shyur LF. Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death. Oncotarget. 8: 56942-56958. PMID 28915644 DOI: 10.18632/oncotarget.18183  0.52
2017 Shang XF, Morris-Natschke SL, Liu YQ, Guo X, Xu XS, Goto M, Li JC, Yang GZ, Lee KH. Biologically active quinoline and quinazoline alkaloids part I. Medicinal Research Reviews. PMID 28902434 DOI: 10.1002/med.21466  0.8
2017 Yuan YX, Zhang Y, Guo LL, Wang YH, Goto M, Morris-Natschke SL, Lee KH, Hao XJ. Tabercorymines A and B, Two Vobasinyl-Ibogan-Type Bisindole Alkaloids from Tabernaemontana corymbosa. Organic Letters. PMID 28876071 DOI: 10.1021/acs.orglett.7b02445  0.8
2017 Wang Y, Lee S, Ha Y, Lam W, Chen SR, Dutschman GE, Gullen EA, Grill SP, Cheng Y, Fürstner A, Francis S, Baker DC, Yang X, Lee KH, Cheng YC. Tylophorine Analogs Allosterically Regulates Heat Shock Cognate Protein 70 And Inhibits Hepatitis C Virus Replication. Scientific Reports. 7: 10037. PMID 28855547 DOI: 10.1038/s41598-017-08815-z  0.64
2017 Yang CJ, Song ZL, Goto M, Liu YQ, Hsieh KY, Morris-Natschke SL, Zhao YL, Zhang JX, Lee KH. Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties. Bioorganic & Medicinal Chemistry Letters. PMID 28789891 DOI: 10.1016/j.bmcl.2017.07.078  0.8
2017 Shiau JY, Chang YQ, Nakagawa-Goto K, Lee KH, Shyur LF. Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions. Frontiers in Pharmacology. 8: 398. PMID 28706483 DOI: 10.3389/fphar.2017.00398  0.52
2017 Cui MT, Jiang L, Goto M, Hsu PL, Li L, Zhang Q, Wei L, Yuan SJ, Hamel E, Morris-Natschke SL, Lee KH, Xie L. In Vivo and Mechanistic Studies on Antitumor Lead 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin-2(1H)-one and Its Modification as a Novel Class of Tubulin-Binding Tumor-Vascular Disrupting Agents. Journal of Medicinal Chemistry. PMID 28653846 DOI: 10.1021/acs.jmedchem.7b00273  0.8
2017 Zhou A, Yan L, Lai F, Chen X, Goto M, Lee KH, Xiao Z. Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds. Bioorganic & Medicinal Chemistry Letters. PMID 28625363 DOI: 10.1016/j.bmcl.2017.06.019  0.68
2017 Shiau JY, Nakagawa-Goto K, Lee KH, Shyur LF. Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death. Oncotarget. PMID 28615523 DOI: 10.18632/oncotarget.18183  0.52
2017 Wei L, Wang HL, Huang L, Chen CH, Morris-Natschke SL, Lee KH, Xie L. Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus. Bioorganic & Medicinal Chemistry Letters. PMID 28465101 DOI: 10.1016/j.bmcl.2017.04.068  0.8
2017 Luo P, Xia W, Morris-Natschke SL, Lee KH, Zhao Y, Gu Q, Xu J. Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia. Journal of Natural Products. PMID 28453270 DOI: 10.1021/acs.jnatprod.6b01195  0.8
2017 Wang SB, Cui MT, Wang XF, Ohkoshi E, Goto M, Yang DX, Li L, Yuan S, Morris-Natschke SL, Lee KH, Xie L. Erratum to "Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors" [Bioorg. Med. Chem. 24 (2016) 3083-3092]. Bioorganic & Medicinal Chemistry. PMID 28363445 DOI: 10.1016/j.bmc.2017.03.044  0.8
2017 Hsieh MT, Chang LC, Hung HY, Lin HY, Shih MH, Tsai CH, Kuo SC, Lee KH. New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo. European Journal of Medicinal Chemistry. 131: 141-151. PMID 28319780 DOI: 10.1016/j.ejmech.2017.03.006  0.8
2017 Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa. Journal of Natural Products. PMID 28290698 DOI: 10.1021/acs.jnatprod.6b01151  0.52
2017 Zhu GX, Cheng PL, Goto M, Zhang N, Morris-Natschke SL, Hsieh KY, Yang GZ, Yang QR, Liu YQ, Chen HL, Zhang XS, Lee KH. Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 28285912 DOI: 10.1016/j.bmcl.2017.02.066  0.8
2017 Vijaya Bhaskar Reddy M, Hung HY, Kuo PC, Huang GJ, Chan YY, Huang SC, Wu SJ, Morris-Natschke SL, Lee KH, Wu TS. Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. PMID 28256373 DOI: 10.1016/j.bmcl.2017.02.038  0.8
2017 Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, ... ... Lee KH, et al. Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release. Free Radical Biology & Medicine. PMID 28188927 DOI: 10.1016/j.freeradbiomed.2017.02.018  0.8
2017 Suzuki Y, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. (-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks. Journal of Natural Products. PMID 28099003 DOI: 10.1021/acs.jnatprod.6b01153  0.52
2017 Zhang P, Lee KH, Lee CH. Fretting friction and wear characteristics of magnetorheological fluid under different magnetic field strengths Journal of Magnetism and Magnetic Materials. 421: 13-18. DOI: 10.1016/j.jmmm.2016.07.064  0.36
2016 Liu LN, Ran JQ, Li LJ, Zhao Y, Goto M, Morris-Natschke SL, Lee KH, Zhao BY, Tan CJ. Ochrocephalamine A, a new quinolizidine alkaloid from Oxytropis ochrocephala Bunge. Tetrahedron Letters. 57: 5047-5049. PMID 28066032 DOI: 10.1016/j.tetlet.2016.10.009  0.8
2016 Liu SN, Huang D, Morris-Natschke SL, Ma H, Liu ZH, Seeram NP, Xu J, Lee KH, Gu Q. Euphomilones A and B, ent-Rosane Diterpenoids with 7/5/6 and 5/7/6 Skeletons from Euphorbia milii. Organic Letters. 18: 6132-6135. PMID 27934394 DOI: 10.1021/acs.orglett.6b03142  0.8
2016 Morita C, Kobayashi Y, Saito Y, Miyake K, Tokuda H, Suzuki N, Ichiishi E, Lee KH, Nakagawa-Goto K. Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. 79: 2890-2897. PMID 27933896 DOI: 10.1021/acs.jnatprod.6b00646  0.52
2016 Liao YR, Kuo PC, Tsai WJ, Huang GJ, Lee KH, Wu TS. Bioactive chemical constituents from the root bark of Morus australis. Bioorganic & Medicinal Chemistry Letters. PMID 27908762 DOI: 10.1016/j.bmcl.2016.11.046  0.4
2016 Xin G, Wei Z, Ji C, Zheng H, Gu J, Ma L, Huang W, Morris-Natschke SL, Yeh JL, Zhang R, Qin C, Wen L, Xing Z, Cao Y, Xia Q, ... ... Lee KH, et al. Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release. Scientific Reports. 6: 36222. PMID 27805009 DOI: 10.1038/srep36222  0.8
2016 Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K. Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. PMID 27797192 DOI: 10.1021/acs.jnatprod.6b00645  0.8
2016 Lee KY, Kim YC, Cho SY, Kim SY, Yoon YY, Koh DC, Ha K, Ko KS. Determination of recharge fraction of injection water in combined abstraction-injection wells using continuous radon monitoring. Journal of Environmental Radioactivity. 165: 140-143. PMID 27718382 DOI: 10.1016/j.jenvrad.2016.09.009  0.4
2016 Nakagawa-Goto K, Taniguchi Y, Watanabe Y, Oda A, Ohkoshi E, Hamel E, Lee KH, Goto M. Triethylated chromones with substituted naphthalenes as tubulin inhibitors. Bioorganic & Medicinal Chemistry. PMID 27707623 DOI: 10.1016/j.bmc.2016.09.062  0.52
2016 Zhao Y, Gu Q, Morris-Natschke SL, Chen CH, Lee KH. Incorporation of Privileged Structures into Bevirimat Can Improve Activity against Wild-Type and Bevirimat-Resistant HIV-1. Journal of Medicinal Chemistry. PMID 27676157 DOI: 10.1021/acs.jmedchem.6b00461  0.8
2016 Li R, Morris-Natschke SL, Lee KH. Clerodane diterpenes: sources, structures, and biological activities. Natural Product Reports. PMID 27433555 DOI: 10.1039/c5np00137d  0.48
2016 Wang SB, Cui MT, Wang XF, Ohkoshi E, Goto M, Yang DX, Li L, Yuan S, Morris-Natschke SL, Lee KH, Xie L. Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. PMID 27238842 DOI: 10.1016/j.bmc.2016.05.025  0.8
2016 Liu N, Wei L, Huang L, Yu F, Zheng W, Qin B, Zhu DQ, Morris-Natschke SL, Jiang S, Chen CH, Lee KH, Xie L. Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus. Journal of Medicinal Chemistry. PMID 27070547 DOI: 10.1021/acs.jmedchem.5b01827  0.8
2016 Nakagawa-Goto K, Chen JY, Cheng YT, Lee WL, Takeya M, Saito Y, Lee KH, Shyur LF. Novel sesquiterpene lactone analogues as potent anti-breast cancer agents. Molecular Oncology. PMID 27055598 DOI: 10.1016/j.molonc.2016.03.002  0.48
2016 Feng JH, Nakagawa-Goto K, Lee KH, Shyur LF. A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice. Molecular Cancer Therapeutics. PMID 27048951 DOI: 10.1158/1535-7163.MCT-15-0973  0.52
2016 Song ZL, Wang MJ, Li L, Wu D, Wang YH, Yan LT, Morris-Natschke SL, Liu YQ, Zhao YL, Wang CY, Liu H, Goto M, Liu H, Zhu GX, Lee KH. Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives. European Journal of Medicinal Chemistry. 115: 109-120. PMID 26994847 DOI: 10.1016/j.ejmech.2016.02.070  0.48
2016 Dang Z, Zhu L, Lai W, Bogerd H, Lee KH, Huang L, Chen CH. Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors. Acs Medicinal Chemistry Letters. 7: 240-4. PMID 26985308 DOI: 10.1021/acsmedchemlett.5b00339  0.48
2016 Shih HC, Kuo PC, Wu SJ, Hwang TL, Hung HY, Shen DY, Shieh PC, Liao YR, Lee EJ, Gu Q, Lee KH, Wu TS. Anti-inflammatory neolignans from the roots of Magnolia officinalis. Bioorganic & Medicinal Chemistry. PMID 26928286 DOI: 10.1016/j.bmc.2016.01.049  0.48
2016 Lin YC, Chen YF, Tseng LS, Lee YH, Morris-Natschke SL, Kuo SC, Yang NS, Lee KH, Huang LJ. Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells. European Journal of Medicinal Chemistry. 110: 98-114. PMID 26820553 DOI: 10.1016/j.ejmech.2016.01.004  0.48
2016 Jiang H, Wang Y, Lee K, Rhee I. DRWA: A receiver-centric solution to bufferbloat in cellular networks Ieee Transactions On Mobile Computing. 15: 2719-2734. DOI: 10.1109/TMC.2015.2510641  0.36
2016 Liu X, Zhang Y, Lee KY. Robust distributed MPC for load frequency control of uncertain power systems Control Engineering Practice. 56: 136-147. DOI: 10.1016/j.conengprac.2016.08.007  0.32
2016 Zhang ZY, Wong MS, Lee KH. Evaluation of the representativeness of ground-based visibility for analysing the spatial and temporal variability of aerosol optical thickness in China Atmospheric Environment. 147: 31-45. DOI: 10.1016/j.atmosenv.2016.09.060  0.56
2016 Fu YJ, Lai CL, Hu CC, Sun YM, Wu SY, Chen JT, Huang SH, Hung WS, Lee KR. Extraordinary transport behavior of gases in isothermally annealed poly(4-methyl-1-pentene) membranes Journal of Polymer Science, Part B: Polymer Physics. 54: 2368-2376. DOI: 10.1002/polb.24150  0.4
2015 Tan CJ, Zhao Y, Goto M, Hsieh KY, Yang XM, Morris-Natschke SL, Liu LN, Zhao BY, Lee KH. Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. Bioorganic & Medicinal Chemistry Letters. PMID 26865176 DOI: 10.1016/j.bmcl.2015.09.010  0.48
2015 Yuan WH, Goto M, Hsieh KY, Yuan B, Zhao Y, Morris-Natschke SL, Lee KH. Selective cytotoxic eremophilane-type sesquiterpenes from Penicillium citreonigrum. Journal of Asian Natural Products Research. 1-6. PMID 26666171 DOI: 10.1080/10286020.2015.1115020  0.48
2015 Li J, Goto M, Yang X, Morris-Natschke SL, Huang L, Chen CH, Lee KH. Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. Bioorganic & Medicinal Chemistry Letters. PMID 26598461 DOI: 10.1016/j.bmcl.2015.11.029  0.48
2015 Yan M, Lu Y, Chen CH, Zhao Y, Lee KH, Chen DF. Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme. Journal of Natural Products. PMID 26562066 DOI: 10.1021/acs.jnatprod.5b00660  0.48
2015 Lai W, Huang L, Zhu L, Ferrari G, Chan C, Li W, Lee KH, Chen CH. Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β. Journal of Medicinal Chemistry. PMID 26509731 DOI: 10.1021/acs.jmedchem.5b01233  0.68
2015 Xiao Z, Morris-Natschke SL, Lee KH. Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates. Medicinal Research Reviews. PMID 26359649 DOI: 10.1002/med.21377  0.68
2015 Fang HW, Liao YR, Hwang TL, Shieh PC, Lee KH, Hung HY, Wu TS. Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursors. Bioorganic & Medicinal Chemistry Letters. PMID 26248804 DOI: 10.1016/j.bmcl.2015.07.074  0.68
2015 Wang SB, Wang XF, Qin B, Ohkoshi E, Hsieh KY, Hamel E, Cui MT, Zhu DQ, Goto M, Morris-Natschke SL, Lee KH, Xie L. Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. PMID 26242242 DOI: 10.1016/j.bmc.2015.07.016  0.68
2015 Chao MW, Wang LT, Lai CY, Yang XM, Cheng YW, Lee KH, Pan SL, Teng CM. eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer. Oncotarget. 6: 24092-104. PMID 26204490  0.6
2015 Wu T, Jiang C, Wang L, Morris-Natschke SL, Miao H, Gu L, Xu J, Lee KH, Gu Q. 3,5-Diarylpyrazole Derivatives Obtained by Ammonolysis of the Total Flavonoids from Chrysanthemum indicum Extract Show Potential for the Treatment of Alzheimer's Disease. Journal of Natural Products. PMID 26099993 DOI: 10.1021/acs.jnatprod.5b00156  0.68
2015 Song ZL, Chen HL, Wang YH, Goto M, Gao WJ, Cheng PL, Morris-Natschke SL, Liu YQ, Zhu GX, Wang MJ, Lee KH. Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction. Bioorganic & Medicinal Chemistry Letters. 25: 2690-3. PMID 25987370 DOI: 10.1016/j.bmcl.2015.04.060  0.68
2015 Gao J, Fang C, Xiao Z, Huang L, Chen CH, Wang LT, Lee KH. Discovery of novel 5-fluoro-N (2),N (4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9. Medchemcomm. 6: 444-454. PMID 25914804 DOI: 10.1039/C4MD00412D  0.68
2015 Hsu TI, Chen YJ, Hung CY, Wang YC, Lin SJ, Su WC, Lai MD, Kim SY, Wang Q, Qian K, Goto M, Zhao Y, Kashiwada Y, Lee KH, Chang WC, et al. A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy. Oncotarget. 6: 13671-87. PMID 25909174  0.8
2015 Dang Z, Jung K, Zhu L, Xie H, Lee KH, Chen CH, Huang L. Phenolic diterpenoid derivatives as anti-influenza a virus agents. Acs Medicinal Chemistry Letters. 6: 355-8. PMID 25815159 DOI: 10.1021/ml500533x  0.68
2015 Liu YQ, Li WQ, Morris-Natschke SL, Qian K, Yang L, Zhu GX, Wu XB, Chen AL, Zhang SY, Nan X, Lee KH. Perspectives on Biologically Active Camptothecin Derivatives. Medicinal Research Reviews. 35: 753-89. PMID 25808858 DOI: 10.1002/med.21342  0.68
2015 Fang S, Chen L, Yu M, Cheng B, Lin Y, Morris-Natschke SL, Lee KH, Gu Q, Xu J. Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives. Organic & Biomolecular Chemistry. 13: 4714-26. PMID 25800703 DOI: 10.1039/c5ob00007f  0.8
2015 Wada K, Ohkoshi E, Zhao Y, Goto M, Morris-Natschke SL, Lee KH. Evaluation of Aconitum diterpenoid alkaloids as antiproliferative agents. Bioorganic & Medicinal Chemistry Letters. 25: 1525-31. PMID 25770782 DOI: 10.1016/j.bmcl.2015.02.018  0.68
2015 Wada K, Lee JY, Hung HY, Shi Q, Lin L, Zhao Y, Goto M, Yang PC, Kuo SC, Chen HW, Lee KH. Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects. Bioorganic & Medicinal Chemistry. 23: 1507-14. PMID 25753330 DOI: 10.1016/j.bmc.2015.02.003  0.68
2015 Nakagawa-Goto K, Oda A, Hamel E, Ohkoshi E, Lee KH, Goto M. Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring. Journal of Medicinal Chemistry. 58: 2378-89. PMID 25695315 DOI: 10.1021/jm501859j  0.68
2015 Wu T, Wang Q, Jiang C, Morris-Natschke SL, Cui H, Wang Y, Yan Y, Xu J, Lee KH, Gu Q. Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication. Journal of Natural Products. 78: 500-9. PMID 25647077 DOI: 10.1021/np500988m  0.8
2015 Liu CY, Cheng YY, Chang LC, Huang LJ, Chou LC, Huang CH, Tsai MT, Liao CC, Hsu MH, Lin HY, Wu TS, Wen YF, Zhao Y, Kuo SC, Lee KH. Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines. European Journal of Medicinal Chemistry. 90: 775-87. PMID 25528332 DOI: 10.1016/j.ejmech.2014.11.062  0.68
2015 Chen YF, Lin YC, Morris-Natschke SL, Wei CF, Shen TC, Lin HY, Hsu MH, Chou LC, Zhao Y, Kuo SC, Lee KH, Huang LJ. Synthesis and SAR studies of novel 6,7,8-substituted 4-substituted benzyloxyquinolin-2(1H)-one derivatives for anticancer activity. British Journal of Pharmacology. 172: 1195-221. PMID 25363404 DOI: 10.1111/bph.12992  0.68
2015 Liu YQ, Tian J, Qian K, Zhao XB, Morris-Natschke SL, Yang L, Nan X, Tian X, Lee KH. Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents. Medicinal Research Reviews. 35: 1-62. PMID 24827545 DOI: 10.1002/med.21319  0.68
2014 Yang L, Wang MJ, Zhang ZJ, Morris-Natschke SL, Goto M, Tian J, Liu YQ, Wang CY, Tian X, Yang XM, Lee KH. Synthesis of novel spin-labeled derivatives of 5-FU as potential antineoplastic agents. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 23: 3269-3273. PMID 25722628 DOI: 10.1007/s00044-013-0906-8  0.8
2014 Yang L, Nan X, Li WQ, Wang MJ, Zhao XB, Liu YQ, Zhang ZJ, Lee KH. Synthesis of novel spin-labeled podophyllotoxin derivatives as potential antineoplastic agents: Part XXV. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 23: 4926-4931. PMID 25709376 DOI: 10.1007/s00044-014-1042-9  0.68
2014 Li RJ, Zhao Y, Tokuda H, Yang XM, Wang YH, Shi Q, Morris-Natschke SL, Lou HX, Lee KH. Total synthesis of plagiochin G and derivatives as potential cancer chemopreventive agents. Tetrahedron Letters. 55: 6500-6503. PMID 25574060 DOI: 10.1016/j.tetlet.2014.10.038  0.8
2014 Zhao XB, Wu D, Wang MJ, Goto M, Morris-Natschke SL, Liu YQ, Wu XB, Song ZL, Zhu GX, Lee KH. Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry. 22: 6453-8. PMID 25438769 DOI: 10.1016/j.bmc.2014.09.035  0.8
2014 Gu W, Zhang Y, Hao XJ, Yang FM, Sun QY, Morris-Natschke SL, Lee KH, Wang YH, Long CL. Indole alkaloid glycosides from the aerial parts of Strobilanthes cusia. Journal of Natural Products. 77: 2590-4. PMID 25427242 DOI: 10.1021/np5003274  0.68
2014 Wu SY, Pan SL, Xiao ZY, Hsu JL, Chen MC, Lee KH, Teng CM. NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells. Plos One. 9: e112220. PMID 25372714 DOI: 10.1371/journal.pone.0112220  0.68
2014 Wang YH, Goto M, Wang LT, Hsieh KY, Morris-Natschke SL, Tang GH, Long CL, Lee KH. Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues. Bioorganic & Medicinal Chemistry Letters. 24: 4818-21. PMID 25241925 DOI: 10.1016/j.bmcl.2014.08.063  0.68
2014 Wang S, Li RJ, Zhu RX, Hu XY, Guo YX, Zhou JC, Lin ZM, Zhang JZ, Wu JY, Kang YQ, Morris-Natschke SL, Lee KH, Yuan HQ, Lou HX. Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens. Journal of Natural Products. 77: 2081-7. PMID 25226363 DOI: 10.1021/np5004559  0.8
2014 Dang Z, Jung K, Zhu L, Lai W, Xie H, Lee KH, Huang L, Chen CH. Identification and synthesis of quinolizidines with anti-influenza a virus activity. Acs Medicinal Chemistry Letters. 5: 942-6. PMID 25147619 DOI: 10.1021/ml500236n  0.68
2014 Liu WT, Chen C, Lu IC, Kuo SC, Lee KH, Chen TL, Song TS, Lu YL, Gean PW, Hour MJ. MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex. Neuropharmacology. 86: 219-27. PMID 25107587 DOI: 10.1016/j.neuropharm.2014.07.014  0.68
2014 Liu N, Qin B, Sun LQ, Yu F, Lu L, Jiang S, Lee KH, Xie L. Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors Bioorganic and Medicinal Chemistry Letters. 24: 3719-3723. PMID 25042339 DOI: 10.1016/j.bmcl.2014.07.011  0.68
2014 Zhao XB, Goto M, Song ZL, Morris-Natschke SL, Zhao Y, Wu D, Yang L, Li SG, Liu YQ, Zhu GX, Wu XB, Lee KH. Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 24: 3850-3. PMID 25008456 DOI: 10.1016/j.bmcl.2014.06.060  0.8
2014 Wang MJ, Liu YQ, Chang LC, Wang CY, Zhao YL, Zhao XB, Qian K, Nan X, Yang L, Yang XM, Hung HY, Yang JS, Kuo DH, Goto M, Morris-Natschke SL, ... ... Lee KH, et al. Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents. Journal of Medicinal Chemistry. 57: 6008-18. PMID 25003995 DOI: 10.1021/jm5003588  0.68
2014 Wang R, Liu YQ, Ha W, Shi YP, Hwang TL, Huang GJ, Wu TS, Lee KH. In vitro anti-inflammatory effects of diterpenoids and sesquiterpenoids from traditional Chinese medicine Siegesbeckia pubescens. Bioorganic & Medicinal Chemistry Letters. 24: 3944-7. PMID 24997688 DOI: 10.1016/j.bmcl.2014.06.039  0.68
2014 Li RJ, Zhu RX, Zhao Y, Morris-Natschke SL, Chen CH, Wang S, Zhang JZ, Zhou JC, Lou HX, Lee KH. Two new cadinane-type sesquiterpenes from the Chinese liverwort Frullania serrata. Natural Product Research. 28: 1519-24. PMID 24969508 DOI: 10.1080/14786419.2014.909416  0.8
2014 Wu ZY, Liu N, Qin B, Huang L, Yu F, Qian K, Morris-Natschke SL, Jiang S, Chen CH, Lee KH, Xie L. Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS. Chemmedchem. 9: 1546-55. PMID 24895029 DOI: 10.1002/cmdc.201400075  0.8
2014 Wang YH, Morris-Natschke SL, Yang J, Niu HM, Long CL, Lee KH. Anticancer principles from medicinal piper ( hú jiāo) plants. Journal of Traditional and Complementary Medicine. 4: 8-16. PMID 24872928 DOI: 10.4103/2225-4110.124811  0.68
2014 Sprague B, Shi Q, Kim MT, Zhang L, Sedykh A, Ichiishi E, Tokuda H, Lee KH, Zhu H. Design, synthesis and experimental validation of novel potential chemopreventive agents using random forest and support vector machine binary classifiers. Journal of Computer-Aided Molecular Design. 28: 631-46. PMID 24840854 DOI: 10.1007/s10822-014-9748-9  0.48
2014 Shi LS, Kuo SC, Sun HD, Morris-Natschke SL, Lee KH, Wu TS. Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria. Bioorganic & Medicinal Chemistry. 22: 1889-98. PMID 24582402 DOI: 10.1016/j.bmc.2014.01.052  0.68
2014 Kou L, Wang MJ, Wang LT, Zhao XB, Nan X, Yang L, Liu YQ, Morris-Natschke SL, Lee KH. Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions. European Journal of Medicinal Chemistry. 75: 282-8. PMID 24553146 DOI: 10.1016/j.ejmech.2014.01.038  0.68
2014 Wang XF, Guan F, Ohkoshi E, Guo W, Wang L, Zhu DQ, Wang SB, Wang LT, Hamel E, Yang D, Li L, Qian K, Morris-Natschke SL, Yuan S, Lee KH, et al. Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site. Journal of Medicinal Chemistry. 57: 1390-402. PMID 24502232 DOI: 10.1021/jm4016526  0.68
2014 Chen CY, Yang SC, Lee KH, Yang X, Wei LY, Chow LP, Wang TC, Hong TM, Lin JC, Kuan C, Yang PC. The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis. Journal of Medicinal Chemistry. 57: 677-85. PMID 24428777 DOI: 10.1021/jm401686b  0.48
2014 Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Bori ID, Qian K, Lee KH. A-ring modified betulinic acid derivatives as potent cancer preventive agents. Bioorganic & Medicinal Chemistry Letters. 24: 1005-8. PMID 24411124 DOI: 10.1016/j.bmcl.2013.12.041  0.68
2014 Zhang ZJ, Tian J, Wang LT, Wang MJ, Nan X, Yang L, Liu YQ, Morris-Natschke SL, Lee KH. Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. Bioorganic & Medicinal Chemistry. 22: 204-10. PMID 24332656 DOI: 10.1016/j.bmc.2013.11.035  0.68
2014 Yu FL, He XY, Gu C, Ohkoshi E, Wang LT, Wang SB, Lai CY, Yu L, Morris-Natschke SL, Lee KH, Liu S, Xie L. Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway. Bioorganic & Medicinal Chemistry. 22: 325-33. PMID 24315191 DOI: 10.1016/j.bmc.2013.11.018  0.8
2013 Li RJ, Zhu RX, Li YY, Zhou JC, Zhang JZ, Wang S, Ye JP, Wang YH, Morris-Natschke SL, Lee KH, Lou HX. Secondary metabolites from the Chinese liverwort Cephaloziella kiaeri. Journal of Natural Products. 76: 1700-8. PMID 24033150 DOI: 10.1021/np400426a  0.8
2013 Lin YC, Tsai JY, Yang JS, Lee YH, Hamel E, Lee KH, Kuo SC, Huang LJ. The novel synthetic compound 6-acetyl-9-(3,4,5-trimetho-xybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells. International Journal of Oncology. 43: 1596-606. PMID 23970288 DOI: 10.3892/ijo.2013.2069  0.68
2013 Cheng YY, Liu CY, Tsai MT, Lin HY, Yang JS, Wu TS, Kuo SC, Huang LJ, Lee KH. Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead. Bioorganic & Medicinal Chemistry Letters. 23: 5223-7. PMID 23916255 DOI: 10.1016/j.bmcl.2013.06.083  0.68
2013 Cheng YY, Liu CY, Huang LJ, Huang CH, Lee KH, Lin CT, Kuo SC. Mechanistic studies on regioselective dephosphorylation of phosphate prodrugs during a facile synthesis of antitumor phosphorylated 2-phenyl-6,7-methylenedioxy-1H-quinolin-4-one. Molecules (Basel, Switzerland). 18: 8028-45. PMID 23884134 DOI: 10.3390/molecules18078028  0.68
2013 Lu Y, Li YQ, Liu YN, Lee KH, Chen DF. Cytotoxic and potential anticancer constituents from the stems of Schisandra pubescens. Pharmaceutical Biology. 51: 1204-7. PMID 23883077 DOI: 10.3109/13880209.2013.818039  0.48
2013 Wang XF, Wang SB, Ohkoshi E, Wang LT, Hamel E, Qian K, Morris-Natschke SL, Lee KH, Xie L. N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin. European Journal of Medicinal Chemistry. 67: 196-207. PMID 23867604 DOI: 10.1016/j.ejmech.2013.06.041  0.68
2013 Chen YF, Lin YC, Huang PK, Chan HC, Kuo SC, Lee KH, Huang LJ. Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase. Bioorganic & Medicinal Chemistry. 21: 5064-75. PMID 23867385 DOI: 10.1016/j.bmc.2013.06.046  0.68
2013 Wei S, Tang YB, Hua H, Ohkoshi E, Goto M, Wang LT, Lee KH, Xiao Z. Discovery of novel andrographolide derivatives as cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 23: 4056-60. PMID 23768904 DOI: 10.1016/j.bmcl.2013.05.061  0.68
2013 Zhao Y, Su J, Goto M, Morris-Natschke SL, Li Y, Zhao QS, Yao ZJ, Lee KH. Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation. Journal of Medicinal Chemistry. 56: 4749-57. PMID 23725535 DOI: 10.1021/jm400479p  0.68
2013 Shih HC, Hwang TL, Chen HC, Kuo PC, Lee EJ, Lee KH, Wu TS. Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of Magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release. Plos One. 8: e59502. PMID 23667420 DOI: 10.1371/journal.pone.0059502  0.4
2013 Lai CY, Pan SL, Yang XM, Chang LH, Chang YL, Yang PC, Lee KH, Teng CM. Depletion of 4E-BP1 and regulation of autophagy lead to YXM110-induced anticancer effects. Carcinogenesis. 34: 2050-60. PMID 23633518 DOI: 10.1093/carcin/bgt146  0.6
2013 Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Kuang X, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lu Y, Lee KH. Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme. Journal of Natural Products. 76: 852-7. PMID 23611151 DOI: 10.1021/np300815t  0.8
2013 Yang Kuo LM, Zhang LJ, Huang HT, Lin ZH, Liaw CC, Cheng HL, Lee KH, Morris-Natschke SL, Kuo YH, Ho HO. Antioxidant lignans and chromone glycosides from Eurya japonica. Journal of Natural Products. 76: 580-7. PMID 23540981 DOI: 10.1021/np3007638  0.8
2013 Li WQ, Wang XL, Qian K, Liu YQ, Wang CY, Yang L, Tian J, Morris-Natschke SL, Zhou XW, Lee KH. Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives. Bioorganic & Medicinal Chemistry. 21: 2363-9. PMID 23490151 DOI: 10.1016/j.bmc.2013.01.069  0.8
2013 Chen M, Xu X, Xu B, Yang P, Liao Z, Morris-Natschke SL, Lee KH, Chen D. Neglschisandrins E-F: two new lignans and related cytotoxic lignans from Schisandra neglecta. Molecules (Basel, Switzerland). 18: 2297-306. PMID 23429345 DOI: 10.3390/molecules18022297  0.8
2013 Dang Z, Ho P, Zhu L, Qian K, Lee KH, Huang L, Chen CH. New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1. Journal of Medicinal Chemistry. 56: 2029-37. PMID 23379607 DOI: 10.1021/jm3016969  0.8
2013 Liu YQ, Li XJ, Zhao CY, Nan X, Tian J, Morris-Natschke SL, Zhang ZJ, Yang XM, Yang L, Li LH, Zhou XW, Lee KH. Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents. Bioorganic & Medicinal Chemistry. 21: 1248-56. PMID 23369687 DOI: 10.1016/j.bmc.2012.12.046  0.8
2013 Wang XF, Ohkoshi E, Wang SB, Hamel E, Bastow KF, Morris-Natschke SL, Lee KH, Xie L. Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. 21: 632-42. PMID 23274123 DOI: 10.1016/j.bmc.2012.11.047  0.68
2013 Huang SM, Cheng YY, Chen MH, Huang CH, Huang LJ, Hsu MH, Kuo SC, Lee KH. Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents. Bioorganic & Medicinal Chemistry Letters. 23: 699-701. PMID 23260351 DOI: 10.1016/j.bmcl.2012.11.105  0.68
2013 Wang Q, Chen TH, Bastow KF, Morris-Natschke SL, Lee KH, Chen DF. Songaricalarins A-E, cytotoxic oplopane sesquiterpenes from Ligularia songarica. Journal of Natural Products. 76: 305-10. PMID 23043462 DOI: 10.1021/np300532p  0.68
2012 Lee KH, Morris-Natschke SL, Yang X, Huang R, Zhou T, Wu SF, Shi Q, Itokawa H. Recent progress of research on medicinal mushrooms, foods, and other herbal products used in traditional Chinese medicine. Journal of Traditional and Complementary Medicine. 2: 84-95. PMID 24716120  0.8
2012 Lee KH, Morris-Natschke S, Qian K, Dong Y, Yang X, Zhou T, Belding E, Wu SF, Wada K, Akiyama T. Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng). Journal of Traditional and Complementary Medicine. 2: 6-26. PMID 24716110  0.8
2012 Dang Z, Jung K, Qian K, Lee KH, Huang L, Chen CH. Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators. Acs Medicinal Chemistry Letters. 3: 925-930. PMID 23330053 DOI: 10.1021/ml3001962  0.8
2012 Wang Y, Wong HC, Gullen EA, Lam W, Yang X, Shi Q, Lee KH, Cheng YC. Cryptopleurine analogs with modification of e ring exhibit different mechanism to rac-cryptopleurine and tylophorine. Plos One. 7: e51138. PMID 23251437 DOI: 10.1371/journal.pone.0051138  0.64
2012 Hung HY, Ohkoshi E, Goto M, Nakagawa-Goto K, Lee KH. 1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity. Bioorganic & Medicinal Chemistry Letters. 22: 7726-9. PMID 23122817 DOI: 10.1016/j.bmcl.2012.09.096  0.8
2012 Liu Y, Qian K, Wang CY, Chen CH, Yang X, Lee KH. Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 7530-3. PMID 23122524 DOI: 10.1016/j.bmcl.2012.10.041  0.8
2012 Liu YQ, Dai W, Wang CY, Morris-Natschke SL, Zhou XW, Yang L, Yang XM, Li WQ, Lee KH. Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 22: 7659-61. PMID 23102893 DOI: 10.1016/j.bmcl.2012.10.002  0.8
2012 Qian K, Bori ID, Chen CH, Huang L, Lee KH. Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors. Journal of Medicinal Chemistry. 55: 8128-36. PMID 22978745 DOI: 10.1021/jm301040s  0.68
2012 Sun LQ, Zhu L, Qian K, Qin B, Huang L, Chen CH, Lee KH, Xie L. Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. Journal of Medicinal Chemistry. 55: 7219-29. PMID 22856541 DOI: 10.1021/jm3007678  0.8
2012 Cheng YY, Yang JS, Tsai SC, Liaw CC, Chung JG, Huang LJ, Lee KH, Lu CC, Chien HC, Tsuzuki M, Kuo SC. The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells. Oncology Reports. 28: 1482-90. PMID 22825350 DOI: 10.3892/or.2012.1923  0.44
2012 Yang X, Shi Q, Lai CY, Chen CY, Ohkoshi E, Yang SC, Wang CY, Bastow KF, Wu TS, Pan SL, Teng CM, Yang PC, Lee KH. Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. Journal of Medicinal Chemistry. 55: 6751-61. PMID 22823514 DOI: 10.1021/jm3001218  0.68
2012 Dang Z, Qian K, Ho P, Zhu L, Lee KH, Huang L, Chen CH. Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. Bioorganic & Medicinal Chemistry Letters. 22: 5190-4. PMID 22818973 DOI: 10.1016/j.bmcl.2012.06.080  0.8
2012 Shen DY, Chao CH, Chan HH, Huang GJ, Hwang TL, Lai CY, Lee KH, Thang TD, Wu TS. Bioactive constituents of Clausena lansium and a method for discrimination of aldose enantiomers. Phytochemistry. 82: 110-7. PMID 22818357 DOI: 10.1016/j.phytochem.2012.06.019  0.4
2012 Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC, Lee KH. Correction to first total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Journal of Medicinal Chemistry. 55: 6985. PMID 22817473 DOI: 10.1021/jm300948p  0.8
2012 Wu TS, Sun CR, Lee KH. Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis. Natural Product Communications. 7: 725-7. PMID 22816292  0.4
2012 Wang LT, Pan SL, Chen TH, Dong Y, Lee KH, Teng CM. DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells. Chembiochem : a European Journal of Chemical Biology. 13: 1663-72. PMID 22761044 DOI: 10.1002/cbic.201200191  0.64
2012 Bori ID, Hung HY, Qian K, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry. Tetrahedron Letters. 53: 1987-1989. PMID 22711941 DOI: 10.1016/j.tetlet.2012.02.022  0.68
2012 Ye D, Shi Q, Leung CH, Kim SW, Park SY, Gullen EA, Jiang ZL, Zhu H, Morris-Natschke SL, Cheng YC, Lee KH. Antitumor agents 294. Novel E-ring-modified camptothecin-4β-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents. Bioorganic & Medicinal Chemistry. 20: 4489-94. PMID 22698783 DOI: 10.1016/j.bmc.2012.05.030  0.8
2012 Shi Q, Wada K, Ohkoshi E, Lin L, Huang R, Morris-Natschke SL, Goto M, Lee KH. Antitumor agents 290. Design, synthesis, and biological evaluation of new LNCaP and PC-3 cytotoxic curcumin analogs conjugated with anti-androgens. Bioorganic & Medicinal Chemistry. 20: 4020-31. PMID 22672984 DOI: 10.1016/j.bmc.2012.05.011  0.8
2012 Li J, Hua HM, Tang YB, Zhang S, Ohkoshi E, Lee KH, Xiao Zy. Synthesis and evaluation of novel podophyllotoxin analogs. Bioorganic & Medicinal Chemistry Letters. 22: 4293-5. PMID 22658864 DOI: 10.1016/j.bmcl.2012.05.033  0.48
2012 Hung HY, Ohkoshi E, Goto M, Bastow KF, Nakagawa-Goto K, Lee KH. Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs. Journal of Medicinal Chemistry. 55: 5413-24. PMID 22612652 DOI: 10.1021/jm300378k  0.68
2012 Yen CT, Nakagawa-Goto K, Hwang TL, Morris-Natschke SL, Bastow KF, Wu YC, Lee KH. Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 22: 4018-22. PMID 22595179 DOI: 10.1016/j.bmcl.2012.04.084  0.68
2012 Hung HY, Qian K, Morris-Natschke SL, Hsu CS, Lee KH. Recent discovery of plant-derived anti-diabetic natural products. Natural Product Reports. 29: 580-606. PMID 22491825 DOI: 10.1039/c2np00074a  0.8
2012 Zhou T, Ohkoshi E, Shi Q, Bastow KF, Lee KH. Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy. Bioorganic & Medicinal Chemistry Letters. 22: 3219-22. PMID 22465634 DOI: 10.1016/j.bmcl.2012.03.037  0.68
2012 Xu K, Xiao Z, Tang YB, Huang L, Chen CH, Ohkoshi E, Lee KH. Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2772-4. PMID 22437113 DOI: 10.1016/j.bmcl.2012.02.086  0.8
2012 Sun LQ, Qin B, Huang L, Qian K, Chen CH, Lee KH, Xie L. Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2376-9. PMID 22406117 DOI: 10.1016/j.bmcl.2012.02.055  0.8
2012 Wang CY, Tsai AC, Peng CY, Chang YL, Lee KH, Teng CM, Pan SL. Dehydrocostuslactone suppresses angiogenesis in vitro and in vivo through inhibition of Akt/GSK-3β and mTOR signaling pathways. Plos One. 7: e31195. PMID 22359572 DOI: 10.1371/journal.pone.0031195  0.6
2012 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Kim Y, Lee EY, Lee KH. Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility. Journal of Natural Products. 75: 370-7. PMID 22304236 DOI: 10.1021/np2007878  0.68
2012 Chen Y, Liu HR, Liu HS, Cheng M, Xia P, Qian K, Wu PC, Lai CY, Xia Y, Yang ZY, Morris-Natschke SL, Lee KH. Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents. European Journal of Medicinal Chemistry. 49: 74-85. PMID 22265685 DOI: 10.1016/j.ejmech.2011.12.025  0.8
2012 Hsu MH, Liu CY, Lin CM, Chen YJ, Chen CJ, Lin YF, Huang LJ, Lee KH, Kuo SC. 2-(3-Methoxyphenyl)-5-methyl-1,8-naphthyridin-4(1H)-one (HKL-1) induces G2/M arrest and mitotic catastrophe in human leukemia HL-60 cells. Toxicology and Applied Pharmacology. 259: 219-26. PMID 22245593 DOI: 10.1016/j.taap.2011.12.026  0.44
2012 Liu YQ, Ohkoshi E, Li LH, Yang L, Lee KH. Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 920-3. PMID 22204911 DOI: 10.1016/j.bmcl.2011.12.024  0.52
2012 Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Morris-Natschke SL, Lee KH. Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(†). Pharmaceutical Biology. 50: 18-24. PMID 22196579 DOI: 10.3109/13880209.2011.608078  0.8
2012 Wada K, Ohkoshi E, Morris-Natschke SL, Bastow KF, Lee KH. Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line. Bioorganic & Medicinal Chemistry Letters. 22: 249-52. PMID 22142543 DOI: 10.1016/j.bmcl.2011.11.026  0.68
2012 Vijaya Bhaskar Reddy M, Shen YC, Ohkoshi E, Bastow KF, Qian K, Lee KH, Wu TS. Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents. European Journal of Medicinal Chemistry. 47: 97-103. PMID 22115618 DOI: 10.1016/j.ejmech.2011.10.026  0.68
2012 Zhou T, Shi Q, Chen CH, Huang L, Ho P, Morris-Natschke SL, Lee KH. Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents. European Journal of Medicinal Chemistry. 47: 86-96. PMID 22063755 DOI: 10.1016/j.ejmech.2011.10.025  0.8
2012 Chen MC, Pan SL, Shi Q, Xiao Z, Lee KH, Li TK, Teng CM. QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. Cancer Science. 103: 80-7. PMID 21920000 DOI: 10.1111/j.1349-7006.2011.02103.x  0.68
2011 Nakagawa-Goto K, Bastow KF, Ohkoshi E, Morris-Natschke SL, Lee KH. Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents. Medicinal Chemistry. 1. PMID 23293751 DOI: 10.4172/2161-0444.1000101  0.8
2011 Vijaya Bhaskar Reddy M, Tsai WJ, Qian K, Lee KH, Wu TS. Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation. Bioorganic & Medicinal Chemistry. 19: 7711-9. PMID 22055718 DOI: 10.1016/j.bmc.2011.08.004  0.68
2011 Soares J, Keppler BR, Wang X, Lee KH, Jarstfer MB. ortho-Quinone tanshinones directly inhibit telomerase through an oxidative mechanism mediated by hydrogen peroxide. Bioorganic & Medicinal Chemistry Letters. 21: 7474-8. PMID 22044621 DOI: 10.1016/j.bmcl.2011.09.112  0.68
2011 Huang L, Ho P, Yu J, Zhu L, Lee KH, Chen CH. Picomolar dichotomous activity of gnidimacrin against HIV-1. Plos One. 6: e26677. PMID 22039528 DOI: 10.1371/journal.pone.0026677  0.8
2011 Chen CT, Hsu MH, Cheng YY, Liu CY, Chou LC, Huang LJ, Wu TS, Yang X, Lee KH, Kuo SC. Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs. European Journal of Medicinal Chemistry. 46: 6046-56. PMID 22030314 DOI: 10.1016/j.ejmech.2011.10.017  0.48
2011 Kurimoto S, Kashiwada Y, Morris-Natschke SL, Lee KH, Takaishi Y. Dyscusins A-C, three new steroids from the leaves of Dysoxylum cumingianum. Chemical & Pharmaceutical Bulletin. 59: 1303-6. PMID 21963644 DOI: JST.JSTAGE/cpb/59.1303  0.8
2011 Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. European Journal of Pharmacology. 670: 96-104. PMID 21907193 DOI: 10.1016/j.ejphar.2011.08.006  0.44
2011 Liu HS, Xu SQ, Cheng M, Chen Y, Xia P, Qian K, Xia Y, Yang ZY, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity. Bioorganic & Medicinal Chemistry Letters. 21: 5831-4. PMID 21871800 DOI: 10.1016/j.bmcl.2011.07.105  0.8
2011 Chen Y, Cheng M, Liu FQ, Xia P, Qian K, Yu D, Xia Y, Yang ZY, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues. European Journal of Medicinal Chemistry. 46: 4924-36. PMID 21864952 DOI: 10.1016/j.ejmech.2011.07.051  0.8
2011 Qian K, Kim SY, Hung HY, Huang L, Chen CH, Lee KH. New betulinic acid derivatives as potent proteasome inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5944-7. PMID 21856154 DOI: 10.1016/j.bmcl.2011.07.072  0.8
2011 Wu SF, Hwang TL, Chen SL, Wu CC, Ohkoshi E, Lee KH, Chang FR, Wu YC. Bioactive components from the heartwood of Pterocarpus santalinus. Bioorganic & Medicinal Chemistry Letters. 21: 5630-2. PMID 21784631 DOI: 10.1016/j.bmcl.2011.06.036  0.48
2011 Wang Q, Hu W, Wang S, Pan Z, Tao L, Guo X, Qian K, Chen CH, Lee KH, Chang J. Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents. European Journal of Medicinal Chemistry. 46: 4178-83. PMID 21745701 DOI: 10.1016/j.ejmech.2011.06.020  0.8
2011 Yang X, Shi Q, Yang SC, Chen CY, Yu SL, Bastow KF, Morris-Natschke SL, Wu PC, Lai CY, Wu TS, Pan SL, Teng CM, Lin JC, Yang PC, Lee KH. Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. Journal of Medicinal Chemistry. 54: 5097-107. PMID 21668000 DOI: 10.1021/jm200330s  0.68
2011 Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lee KH. Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L. Organic Letters. 13: 2904-7. PMID 21561135 DOI: 10.1021/ol200889s  0.8
2011 Rosselli S, Bruno M, Maggio A, Raccuglia RA, Safder M, Lai CY, Bastow KF, Lee KH. Cytotoxic geranylflavonoids from Bonannia graeca. Phytochemistry. 72: 942-5. PMID 21459391 DOI: 10.1016/j.phytochem.2011.03.005  0.68
2011 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity. Bioorganic & Medicinal Chemistry Letters. 21: 2341-4. PMID 21420855 DOI: 10.1016/j.bmcl.2011.02.084  0.68
2011 Chan HH, Hwang TL, Reddy MV, Li DT, Qian K, Bastow KF, Lee KH, Wu TS. Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds. Journal of Natural Products. 74: 796-802. PMID 21417387 DOI: 10.1021/np100851s  0.68
2011 Dang Z, Lin A, Ho P, Soroka D, Lee KH, Huang L, Chen CH. Synthesis and proteasome inhibition of lithocholic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 21: 1926-8. PMID 21388808 DOI: 10.1016/j.bmcl.2011.02.041  0.8
2011 Reddy MV, Shen YC, Yang JS, Hwang TL, Bastow KF, Qian K, Lee KH, Wu TS. New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis. Bioorganic & Medicinal Chemistry. 19: 1895-906. PMID 21377368 DOI: 10.1016/j.bmc.2011.02.004  0.68
2011 Kuo TC, Chiang PC, Yu CC, Nakagawa-Goto K, Bastow KF, Lee KH, Guh JH. A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways. Biochemical Pharmacology. 81: 1136-44. PMID 21371443 DOI: 10.1016/j.bcp.2011.02.013  0.68
2011 Huang SM, Yang JS, Tsai SC, Chen MH, Hsu MH, Lin HY, Chou LC, Chinag JH, Lee KH, Huang LJ, Kuo SC. The novel synthesized 2-(3-(methylamino)phenyl)-6-(pyrrolidin-1-yl)quinolin-4-one (Smh-3) compound induces G2/M phase arrest and mitochondrial-dependent apoptotic cell death through inhibition of CDK1 and AKT activity in HL-60 human leukemia cells. International Journal of Oncology. 38: 1357-64. PMID 21344160 DOI: 10.3892/ijo.2011.952  0.44
2011 Yang ML, Kuo PC, Hwang TL, Chiou WF, Qian K, Lai CY, Lee KH, Wu TS. Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives. Bioorganic & Medicinal Chemistry. 19: 1674-82. PMID 21316977 DOI: 10.1016/j.bmc.2011.01.034  0.8
2011 Oberoi L, Akiyama T, Lee KH, Liu SJ. The aqueous extract, not organic extracts, of Terminalia arjuna bark exerts cardiotonic effect on adult ventricular myocytes. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 18: 259-65. PMID 21315570 DOI: 10.1016/j.phymed.2010.07.006  0.44
2011 Nakagawa-Goto K, Wu PC, Bastow KF, Yang SC, Yu SL, Chen HY, Lin JC, Goto M, Morris-Natschke SL, Yang PC, Lee KH. Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action. Bioorganic & Medicinal Chemistry. 19: 1816-22. PMID 21296579 DOI: 10.1016/j.bmc.2011.01.001  0.68
2011 Nakagawa-Goto K, Wu PC, Lai CY, Hamel E, Zhu H, Zhang L, Kozaka T, Ohkoshi E, Goto M, Bastow KF, Lee KH. Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. Journal of Medicinal Chemistry. 54: 1244-55. PMID 21284385 DOI: 10.1021/jm1011947  0.68
2011 Dong Y, Morris-Natschke SL, Lee KH. Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents. Natural Product Reports. 28: 529-42. PMID 21225077 DOI: 10.1039/c0np00035c  0.8
2011 Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EY, Bastow KF, Lee KH. Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 52-7. PMID 21147529 DOI: 10.1016/j.bmcl.2010.11.077  0.68
2011 Zhang P, Xu L, Qian K, Liu J, Zhang L, Lee KH, Sun H. Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. Bioorganic & Medicinal Chemistry Letters. 21: 338-41. PMID 21123066 DOI: 10.1016/j.bmcl.2010.11.004  0.8
2011 Shi LS, Chao CH, Shen DY, Chan HH, Chen CH, Liao YR, Wu SJ, Leu YL, Shen YC, Kuo YH, Lee EJ, Qian K, Wu TS, Lee KH. Biologically active constituents from the fruiting body of Taiwanofungus camphoratus. Bioorganic & Medicinal Chemistry. 19: 677-83. PMID 21115251 DOI: 10.1016/j.bmc.2010.10.032  0.8
2011 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 546-9. PMID 21087859 DOI: 10.1016/j.bmcl.2010.10.074  0.68
2010 Zhou T, Shi Q, Bastow KF, Lee KH. Antitumor agents 286. Design, synthesis, and structure-activity relationships of 3'R,4'R-disubstituted-2',2'-dimethyldihydropyrano[2,3-f]chromone (DSP) analogues as potent chemosensitizers to overcome multidrug resistance. Journal of Medicinal Chemistry. 53: 8700-8. PMID 21082774 DOI: 10.1021/jm101249z  0.68
2010 Tian X, Qin B, Wu Z, Wang X, Lu H, Morris-Natschke SL, Chen CH, Jiang S, Lee KH, Xie L. Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 53: 8287-97. PMID 21049929 DOI: 10.1021/jm100738d  0.8
2010 Wu SJ, Leu YL, Chen CH, Chao CH, Shen DY, Chan HH, Lee EJ, Wu TS, Wang YH, Shen YC, Qian K, Bastow KF, Lee KH. Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. Journal of Natural Products. 73: 1756-62. PMID 21028898 DOI: 10.1021/np1002143  0.68
2010 Chou LC, Tsai MT, Hsu MH, Wang SH, Way TD, Huang CH, Lin HY, Qian K, Dong Y, Lee KH, Huang LJ, Kuo SC. Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents. Journal of Medicinal Chemistry. 53: 8047-58. PMID 20973552 DOI: 10.1021/jm100780c  0.8
2010 Xu SQ, Yan X, Chen Y, Xia P, Qian K, Yu D, Xia Y, Yang ZY, Morris-Natschke SL, Lee KH. Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs. Bioorganic & Medicinal Chemistry. 18: 7203-11. PMID 20846868 DOI: 10.1016/j.bmc.2010.08.031  0.8
2010 Chang CL, Zhang LJ, Chen RY, Kuo LM, Huang JP, Huang HC, Lee KH, Wu YC, Kuo YH. Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. Journal of Natural Products. 73: 1482-8. PMID 20825224 DOI: 10.1021/np100181c  0.48
2010 Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natschke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K, ... ... Lee KH, et al. Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent. Journal of Natural Products. 73: 1553-8. PMID 20738103 DOI: 10.1021/np100406d  0.68
2010 Nakagawa-Goto K, Chang PC, Lai CY, Hung HY, Chen TH, Wu PC, Zhu H, Sedykh A, Bastow KF, Lee KH. Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues. Journal of Medicinal Chemistry. 53: 6699-705. PMID 20735140 DOI: 10.1021/jm100846r  0.68
2010 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 20: 4085-7. PMID 20542429 DOI: 10.1016/j.bmcl.2010.05.079  0.68
2010 Tang J, Qian K, Zhang BN, Chen Y, Xia P, Yu D, Xia Y, Yang ZY, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents. Bioorganic & Medicinal Chemistry. 18: 4363-73. PMID 20537902 DOI: 10.1016/j.bmc.2010.04.089  0.8
2010 Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, ... ... Lee KH, et al. Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. Journal of Medicinal Chemistry. 53: 2299-308. PMID 20148565 DOI: 10.1021/jm1000858  0.68
2010 Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH. Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. Bioorganic & Medicinal Chemistry. 18: 803-8. PMID 20034799 DOI: 10.1016/j.bmc.2009.11.049  0.68
2009 Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Bastow KF, Morris-Natschke SL, Lee KH. Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents. Bioorganic & Medicinal Chemistry Letters. 19: 6289-92. PMID 19819136 DOI: 10.1016/j.bmcl.2009.09.092  0.68
2009 Qian K, Yu D, Chen CH, Huang L, Morris-Natschke SL, Nitz TJ, Salzwedel K, Reddick M, Allaway GP, Lee KH. Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. Journal of Medicinal Chemistry. 52: 3248-58. PMID 19388685 DOI: 10.1021/jm900136j  0.68
2009 Lin JC, Yang SC, Hong TM, Yu SL, Shi Q, Wei L, Chen HY, Yang PC, Lee KH. Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways. Journal of Medicinal Chemistry. 52: 1903-11. PMID 19284764 DOI: 10.1021/jm801344j  0.48
2009 Lee CL, Chang FR, Yen MH, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Wu YC, Lee KH. Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis. Journal of Natural Products. 72: 210-3. PMID 19193043 DOI: 10.1021/np800622a  0.68
2009 Lee KH, Yu DH, Lee YS. Gene expression profiling of rat cerebral cortex development using cDNA microarrays. Neurochemical Research. 34: 1030-8. PMID 18987971 DOI: 10.1007/s11064-008-9867-6  0.4
2008 Xie L, Guo HF, Lu H, Zhuang XM, Zhang AM, Wu G, Ruan JX, Zhou T, Yu D, Qian K, Lee KH, Jiang S. Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK). Journal of Medicinal Chemistry. 51: 7689-96. PMID 19053755 DOI: 10.1021/jm8003009  0.8
2008 Lee CL, Nakagawa-Goto K, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Chang FR, Wu YC, Lee KH. Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis. Bioorganic & Medicinal Chemistry Letters. 18: 4275-7. PMID 18640035 DOI: 10.1016/j.bmcl.2008.06.099  0.68
2008 Huang L, Yu D, Ho P, Qian K, Lee KH, Chen CH. Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives. Bioorganic & Medicinal Chemistry. 16: 6696-701. PMID 18562200 DOI: 10.1016/j.bmc.2008.05.078  0.8
2008 Gao W, Chen AP, Leung CH, Gullen EA, Fürstner A, Shi Q, Wei L, Lee KH, Cheng YC. Structural analogs of tylophora alkaloids may not be functional analogs. Bioorganic & Medicinal Chemistry Letters. 18: 704-9. PMID 18077159 DOI: 10.1016/j.bmcl.2007.11.054  0.68
2007 Cheon SH, Lee KH, Kwon JY, Ryu HN, Yu DH, Choi YS, Kim DI. Effects of silkworm hemolymph on cell viability and hCTLA4Ig production in transgenic rice cell suspension cultures. Journal of Microbiology and Biotechnology. 17: 1944-8. PMID 18167440  0.4
2007 Qian K, Nakagawa-Goto K, Yu D, Morris-Natschke SL, Nitz TJ, Kilgore N, Allaway GP, Lee KH. Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 17: 6553-7. PMID 17935987 DOI: 10.1016/j.bmcl.2007.09.081  0.8
2007 Suzuki M, Yu D, Morris-Natschke SL, Smith PC, Lee KH. Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives. Bioorganic & Medicinal Chemistry. 15: 6852-8. PMID 17719228 DOI: 10.1016/j.bmc.2006.12.013  0.8
2007 Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC, Lee KH. First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Journal of Medicinal Chemistry. 50: 3921-7. PMID 17622129 DOI: 10.1021/jm070363a  0.8
2007 Wei L, Shi Q, Bastow KF, Brossi A, Morris-Natschke SL, Nakagawa-Goto K, Wu TS, Pan SL, Teng CM, Lee KH. Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Journal of Medicinal Chemistry. 50: 3674-80. PMID 17585747 DOI: 10.1021/jm061366a  0.68
2007 Zhang S, Wei L, Bastow K, Zheng W, Brossi A, Lee KH, Tropsha A. Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents. Journal of Computer-Aided Molecular Design. 21: 97-112. PMID 17340042 DOI: 10.1007/s10822-007-9102-6  0.68
2007 Yu D, Morris-Natschke SL, Lee KH. New developments in natural products-based anti-AIDS research. Medicinal Research Reviews. 27: 108-32. PMID 16888749 DOI: 10.1002/med.20075  0.8
2006 Wang AG, Lee KY, Kim SY, Choi JY, Lee KH, Kim WH, Wang HJ, Kim JM, Park MG, Yeom YI, Kim NS, Yu DY, Lee DS. The expression of estrogen receptors in hepatocellular carcinoma in Korean patients. Yonsei Medical Journal. 47: 811-6. PMID 17191310 DOI: 10.3349/ymj.2006.47.6.811  0.4
2006 Horiuch M, Murakami C, Fukamiya N, Yu D, Chen TH, Bastow KF, Zhang DC, Takaishi Y, Imakura Y, Lee KH. Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids. Journal of Natural Products. 69: 1271-4. PMID 16989518 DOI: 10.1021/np060124a  0.68
2006 Yu D, Sakurai Y, Chen CH, Chang FR, Huang L, Kashiwada Y, Lee KH. Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. Journal of Medicinal Chemistry. 49: 5462-9. PMID 16942019 DOI: 10.1021/jm0601912  0.8
2006 Wei L, Brossi A, Kendall R, Bastow KF, Morris-Natschke SL, Shi Q, Lee KH. Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents. Bioorganic & Medicinal Chemistry. 14: 6560-9. PMID 16809043 DOI: 10.1016/j.bmc.2006.06.009  0.68
2005 Ahn MJ, Yoo YD, Lee KH, Ahn JI, Yu DH, Lee HS, Oh HS, Choi JH, Lee YS. cDNA microarray analysis of differential gene expression in gastric cancer cells sensitive and resistant to 5-fluorouracil and cisplatin. Cancer Research and Treatment : Official Journal of Korean Cancer Association. 37: 54-62. PMID 19956511 DOI: 10.4143/crt.2005.37.1.54  0.4
2005 Nedashkovskaya OI, Kim SB, Suzuki M, Shevchenko LS, Lee MS, Lee KH, Park MS, Frolova GM, Oh HW, Bae KS, Park HY, Mikhailov VV. Pontibacter actiniarum gen. nov., sp. nov., a novel member of the phylum 'Bacteroidetes', and proposal of Reichenbachiella gen. nov. as a replacement for the illegitimate prokaryotic generic name Reichenbachia Nedashkovskaya et al. 2003. International Journal of Systematic and Evolutionary Microbiology. 55: 2583-8. PMID 16280531 DOI: 10.1099/ijs.0.63819-0  0.56
2005 Suzuki M, Li Y, Smith PC, Swenberg JA, Martin DE, Morris-Natschke SL, Lee KH. Anti-AIDS agents 65: investigation of the in vitro oxidative metabolism of 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-hiv agents. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1588-92. PMID 16087699 DOI: 10.1124/dmd.105.004218  0.8
2005 Xie L, Zhao CH, Zhou T, Chen HF, Fan BT, Chen XH, Ma JZ, Li JY, Bao ZY, Lo Z, Yu D, Lee KH. Molecular modeling, design, synthesis, and biological evaluation of novel 3',4'-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents. Bioorganic & Medicinal Chemistry. 13: 6435-49. PMID 16061386 DOI: 10.1016/j.bmc.2005.06.057  0.8
2005 Yu D, Wild CT, Martin DE, Morris-Natschke SL, Chen CH, Allaway GP, Lee KH. The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV. Expert Opinion On Investigational Drugs. 14: 681-93. PMID 16004596 DOI: 10.1517/13543784.14.6.681  0.8
2005 Nakamura S, Kozuka M, Bastow KF, Tokuda H, Nishino H, Suzuki M, Tatsuzaki J, Morris Natschke SL, Kuo SC, Lee KH. Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters. Bioorganic & Medicinal Chemistry. 13: 4396-401. PMID 15914009 DOI: 10.1016/j.bmc.2005.04.078  0.68
2005 Huang L, Yuan X, Yu D, Lee KH, Chen CH. Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives. Virology. 332: 623-8. PMID 15680427 DOI: 10.1016/j.virol.2004.11.033  0.8
2005 Lai YY, Huang LJ, Lee KH, Xiao Z, Bastow KF, Yamori T, Kuo SC. Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents. Bioorganic & Medicinal Chemistry. 13: 265-75. PMID 15582470 DOI: 10.1016/j.bmc.2004.09.041  0.68
2004 Ahn MJ, Lee KH, Ahn JI, Yu DH, Lee HS, Choi JH, Jang JS, Bae JM, Lee YS. The differential gene expression profiles between sensitive and resistant breast cancer cells to adriamycin by cDNA microarray. Cancer Research and Treatment : Official Journal of Korean Cancer Association. 36: 43-9. PMID 20396564 DOI: 10.4143/crt.2004.36.1.43  0.4
2004 Zhang Q, Chen Y, Xia P, Xia Y, Yang ZY, Yu D, Morris-Natschke SL, Lee KH. Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs. Bioorganic & Medicinal Chemistry Letters. 14: 5855-7. PMID 15501055 DOI: 10.1016/j.bmcl.2004.09.032  0.8
2004 Xiao Z, Bastow KF, Vance JR, Sidwell RS, Wang HK, Chen MS, Shi Q, Lee KH. Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4β-[(4″-benzamido)-amino]-4′-O-demethyl- epipodophyllotoxin derivatives Journal of Medicinal Chemistry. 47: 5140-5148. PMID 15456257 DOI: 10.1021/jm030609l  0.68
2004 Yu DH, Lee KH, Lee JY, Kim S, Shin DM, Kim JH, Lee YS, Lee YS, Oh SK, Moon SY, Lee SH, Lee YS. Changes of gene expression profiles during neuronal differentiation of central nervous system precursors treated with ascorbic acid. Journal of Neuroscience Research. 78: 29-37. PMID 15372504 DOI: 10.1002/jnr.20220  0.4
2004 Yu D, Chen CH, Brossi A, Lee KH. Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents. Journal of Medicinal Chemistry. 47: 4072-82. PMID 15267246 DOI: 10.1021/jm0400505  0.8
2004 Zhu XK, Guan J, Xiao Z, Cosentino LM, Lee KH. Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives. Bioorganic & Medicinal Chemistry. 12: 4267-73. PMID 15246103 DOI: 10.1016/j.bmc.2004.04.048  0.68
2004 Xiao Z, Vance JR, Bastow KF, Brossi A, Wang HK, Lee KH. Antitumor agents. Part 235: Novel 4′-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential Bioorganic and Medicinal Chemistry. 12: 3363-3369. PMID 15158805 DOI: 10.1016/j.bmc.2004.03.056  0.68
2004 Xiao Z, Bastow KF, Vance JR, Lee KH. Antitumor agents. Part 227: Studies on novel 4′-O-demethyl- epipodophyllotoxins as antitumor agents targeting topoisomerase II Bioorganic and Medicinal Chemistry. 12: 3339-3344. PMID 15158802 DOI: 10.1016/j.bmc.2004.03.067  0.68
2004 Han S, Xiao Z, Bastow KF, Lee KH. Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 2979-82. PMID 15125972 DOI: 10.1016/j.bmcl.2004.02.102  0.68
2004 Xiao Z, Han S, Bastow KF, Lee KH. Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. Bioorganic & Medicinal Chemistry Letters. 14: 1581-4. PMID 15006408 DOI: 10.1016/j.bmcl.2003.12.096  0.68
2004 Xie L, Yu D, Wild C, Allaway G, Turpin J, Smith PC, Lee KH. Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives. Journal of Medicinal Chemistry. 47: 756-60. PMID 14736256 DOI: 10.1021/jm030416y  0.8
2003 Ohtsu H, Itokawa H, Xiao Z, Su CY, Shih CC, Chiang T, Chang E, Lee Y, Chiu SY, Chang C, Lee KH. Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids. Bioorganic & Medicinal Chemistry. 11: 5083-90. PMID 14604672  0.68
2003 Golbraikh A, Shen M, Xiao Z, Xiao YD, Lee KH, Tropsha A. Rational selection of training and test sets for the development of validated QSAR models. Journal of Computer-Aided Molecular Design. 17: 241-53. PMID 13677490 DOI: 10.1023/A:1025386326946  0.68
2003 Wu JH, Chang FR, Hayashi Ki, Shiraki H, Liaw CC, Nakanishi Y, Bastow KF, Yu D, Chen IS, Lee KH. Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis. Bioorganic & Medicinal Chemistry Letters. 13: 2223-5. PMID 12798338 DOI: 10.1016/S0960-894X(03)00379-2  0.68
2003 Yu D, Brossi A, Kilgore N, Wild C, Allaway G, Lee KH. Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent. Bioorganic & Medicinal Chemistry Letters. 13: 1575-6. PMID 12699758  0.8
2003 Yu D, Suzuki M, Xie L, Morris-Natschke SL, Lee KH. Recent progress in the development of coumarin derivatives as potent anti-HIV agents. Medicinal Research Reviews. 23: 322-45. PMID 12647313 DOI: 10.1002/med.10034  0.8
2002 Ohtsu H, Xiao Z, Ishida J, Nagai M, Wang HK, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee Y, Tsai MY, Chang C, Lee KH. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. Journal of Medicinal Chemistry. 45: 5037-42. PMID 12408714  0.68
2002 Xiao Z, Xiao YD, Feng J, Golbraikh A, Tropsha A, Lee KH. Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method. Journal of Medicinal Chemistry. 45: 2294-309. PMID 12014968 DOI: 10.1021/jm0105427  0.68
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