Douglas R. Spitz - Publications

Affiliations: 
University of Iowa, Iowa City, IA 
Area:
Oncology, Radiation Chemistry
Website:
https://frrbp.medicine.uiowa.edu/people/douglas-spitz

231 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Roy SJ, Koval OM, Sebag SC, Ait-Aissa K, Allen BG, Spitz DR, Grumbach IM. Inhibition of CaMKII in mitochondria preserves endothelial barrier function after irradiation. Free Radical Biology & Medicine. PMID 31711984 DOI: 10.1016/j.freeradbiomed.2019.11.012  0.36
2019 Bi J, Yang S, Li L, Dai Q, Borcherding N, Wagner BA, Buettner GR, Spitz DR, Leslie KK, Zhang J, Meng X. Metadherin enhances vulnerability of cancer cells to ferroptosis. Cell Death & Disease. 10: 682. PMID 31527591 DOI: 10.1038/s41419-019-1897-2  1
2019 Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB. Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis. Cell Reports. 28: 2608-2619.e6. PMID 31484072 DOI: 10.1016/j.celrep.2019.07.098  0.56
2019 Bodeker KL, Allen BG, Smith MC, Monga V, Sandhu S, Hohl RJ, Carlisle TL, Brown HA, Hollenbeck NJ, Vollstedt S, Greenlee JDW, Howard MA, Mapuskar KA, Seyedin SN, Caster JM, ... ... Spitz DR, et al. First-in-human phase 1 clinical trial of pharmacological ascorbate combined with radiation and temozolomide for newly diagnosed glioblastoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31427282 DOI: 10.1158/1078-0432.CCR-19-0594  1
2019 Spitz DR, Buettner GR, Limoli CL. Response to letter regarding "An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses". Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 31427044 DOI: 10.1016/j.radonc.2019.07.009  1
2019 Petronek MS, Spitz DR, Buettner GR, Allen BG. Linking Cancer Metabolic Dysfunction and Genetic Instability through the Lens of Iron Metabolism. Cancers. 11. PMID 31366108 DOI: 10.3390/cancers11081077  1
2019 Park JH, Elpers C, Reunert J, McCormick ML, Mohr J, Biskup S, Schwartz O, Rust S, Grüneberg M, Seelhöfer A, Schara U, Boltshauser E, Spitz DR, Marquardt T. SOD1 deficiency: a novel syndrome distinct from amyotrophic lateral sclerosis. Brain : a Journal of Neurology. PMID 31332433 DOI: 10.1093/brain/awz182  1
2019 Petronek MS, Wagner BA, Hollenbeck NJ, Caster JM, Spitz DR, Cullen JJ, Buettner GR, Allen BG. Assessment of the Stability of Supraphysiological Ascorbate in Human Blood: Appropriate Handling of Samples from Clinical Trials For Measurements of Pharmacological Ascorbate. Radiation Research. PMID 31039080 DOI: 10.1667/RR15328.1  1
2019 Spitz DR, Buettner GR, Petronek MS, St-Aubin JJ, Flynn RT, Waldron TJ, Limoli CL. An integrated physico-chemical approach for explaining the differential impact of FLASH versus conventional dose rate irradiation on cancer and normal tissue responses. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. PMID 31010709 DOI: 10.1016/j.radonc.2019.03.028  1
2019 Bittle J, Menezes EC, McCormick ML, Spitz DR, Dailey M, Stevens HE. The Role of Redox Dysregulation in the Effects of Prenatal Stress on Embryonic Interneuron Migration. Cerebral Cortex (New York, N.Y. : 1991). PMID 30877797 DOI: 10.1093/cercor/bhz052  1
2019 Mapuskar KA, Anderson CM, Spitz DR, Batinic-Haberle I, Allen BG, E Oberley-Deegan R. Utilizing Superoxide Dismutase Mimetics to Enhance Radiation Therapy Response While Protecting Normal Tissues. Seminars in Radiation Oncology. 29: 72-80. PMID 30573187 DOI: 10.1016/j.semradonc.2018.10.005  0.56
2019 Schoenfeld JD, Alexander MS, Waldron TJ, Sibenaller ZA, Spitz DR, Buettner GR, Allen BG, Cullen JJ. Pharmacological Ascorbate as a Means of Sensitizing Cancer Cells to Radio-Chemotherapy While Protecting Normal Tissue. Seminars in Radiation Oncology. 29: 25-32. PMID 30573181 DOI: 10.1016/j.semradonc.2018.10.006  1
2018 Mapuskar KA, Wen H, Holanda DG, Rastogi P, Steinbach E, Han R, Coleman MC, Attanasio M, Riley DP, Spitz DR, Allen BG, Zepeda-Orozco D. Persistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease. Redox Biology. 20: 98-106. PMID 30296702 DOI: 10.1016/j.redox.2018.09.020  0.76
2018 Alexander MS, Wilkes JG, Schroeder SR, Buettner GR, Wagner BA, Du J, Gibson-Corely K, O'Leary BR, Spitz DR, Buatti JM, Berg DJ, Bodeker KL, Vollstedt S, Brown HA, Allen BG, et al. Pharmacological ascorbate reduces radiation-induced normal tissue toxicity and enhances tumor radiosensitization in pancreatic cancer. Cancer Research. PMID 30254147 DOI: 10.1158/0008-5472.CAN-18-1680  1
2018 Zhu Y, Dean AE, Horikoshi N, Heer C, Spitz DR, Gius D. Emerging evidence for targeting mitochondrial metabolic dysfunction in cancer therapy. The Journal of Clinical Investigation. 128: 3682-3691. PMID 30168803 DOI: 10.1172/JCI120844  1
2018 Luo M, Shang L, Brooks MD, Jiagge E, Zhu Y, Buschhaus JM, Conley S, Fath MA, Davis A, Gheordunescu E, Wang Y, Harouaka R, Lozier A, Triner D, McDermott S, ... ... Spitz DR, et al. Targeting Breast Cancer Stem Cell State Equilibrium through Modulation of Redox Signaling. Cell Metabolism. 28: 69-86.e6. PMID 29972798 DOI: 10.1016/j.cmet.2018.06.006  1
2018 Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA. Corrigendum to: Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells [Redox Biol. (2018) 82-87]. Redox Biology. PMID 29891355 DOI: 10.1016/j.redox.2018.06.001  1
2018 Pennington SM, Klutho PR, Xie L, Broadhurst K, Koval OM, McCormick ML, Spitz DR, Grumbach IM. Defective protein repair under methionine sulfoxide A deletion drives autophagy and ARE-dependent gene transcription. Redox Biology. 16: 401-413. PMID 29649787 DOI: 10.1016/j.redox.2018.04.001  1
2018 O'Leary BR, Houwen FK, Johnson CL, Allen BG, Mezhir JJ, Berg DJ, Cullen JJ, Spitz DR. Pharmacological Ascorbate as an Adjuvant for Enhancing Radiation-Chemotherapy Responses in Gastric Adenocarcinoma. Radiation Research. PMID 29547353 DOI: 10.1667/RR14978.1  1
2018 Zhang X, Yoon JY, Morley M, McLendon JM, Mapuskar KA, Gutmann R, Mehdi H, Bloom HL, Dudley SC, Ellinor PT, Shalaby AA, Weiss R, Tang WHW, Moravec CS, Singh M, ... ... Spitz DR, et al. A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality. The Journal of Clinical Investigation. PMID 29457789 DOI: 10.1172/JCI95710  0.56
2018 Heer CD, Davis AB, Riffe DB, Wagner BA, Falls KC, Allen BG, Buettner GR, Beardsley RA, Riley DP, Spitz DR. Superoxide Dismutase Mimetic GC4419 Enhances the Oxidation of Pharmacological Ascorbate and Its Anticancer Effects in an H₂O₂-Dependent Manner. Antioxidants (Basel, Switzerland). 7. PMID 29351198 DOI: 10.3390/antiox7010018  1
2018 Rashmi R, Huang X, Floberg JM, Elhammali A, McCormick ML, Patti GJ, Spitz DR, Schwarz JK. Radio-resistant Cervical Cancers Are Sensitive to Inhibition of Glycolysis and Redox Metabolism. Cancer Research. PMID 29339540 DOI: 10.1158/0008-5472.CAN-17-2367  1
2017 Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Bradley MD, Wagner BA, Buettner GR, Monga V, Milhem M, Spitz DR, Allen BG. Redox active metals and H2O2 mediate the increased efficacy of pharmacological ascorbate in combination with gemcitabine or radiation in pre-clinical sarcoma models. Redox Biology. 14: 417-422. PMID 29069637 DOI: 10.1016/j.redox.2017.09.012  1
2017 Brandt KE, Falls KC, Schoenfeld JD, Rodman SN, Gu Z, Zhan F, Cullen JJ, Wagner BA, Buettner GR, Allen BG, Berg DJ, Spitz DR, Fath MA. Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells. Redox Biology. 14: 82-87. PMID 28886484 DOI: 10.1016/j.redox.2017.08.017  1
2017 Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, ... ... Spitz DR, et al. O2(⋅-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. 32: 268. PMID 28810149 DOI: 10.1016/j.ccell.2017.07.008  1
2017 Mapuskar KA, Flippo KH, Schoenfeld JD, Riley DP, Strack S, Abu-Hejleh T, Furqan M, Monga V, Domann FE, Buatti JM, Goswami PC, Spitz DR, Allen BG. Mitochondrial superoxide increases age-associated susceptibility of human dermal fibroblasts to radiation and chemotherapy. Cancer Research. PMID 28765155 DOI: 10.1158/0008-5472.CAN-17-0106  1
2017 Zahra A, Fath MA, Opat E, Mapuskar KA, Bhatia SK, Ma DC, Iii SNR, Snyders TP, Chenard CA, Eichenberger-Gilmore JM, Bodeker KL, Ahmann L, Smith BJ, Vollstedt SA, Brown HA, ... ... Spitz DR, et al. Consuming a Ketogenic Diet while Receiving Radiation and Chemotherapy for Locally Advanced Lung Cancer and Pancreatic Cancer: The University of Iowa Experience of Two Phase 1 Clinical Trials. Radiation Research. PMID 28437190 DOI: 10.1667/RR14668.1  1
2017 Sciegienka SJ, Solst SR, Falls KC, Schoenfeld JD, Klinger AR, Ross NL, Rodman SN, Spitz DR, Fath MA. D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress. Free Radical Biology & Medicine. PMID 28389407 DOI: 10.1016/j.freeradbiomed.2017.04.001  0.72
2017 Schoenfeld JD, Sibenaller ZA, Mapuskar KA, Wagner BA, Cramer-Morales KL, Furqan M, Sandhu S, Carlisle TL, Smith MC, Abu Hejleh T, Berg DJ, Zhang J, Keech J, Parekh KR, Bhatia S, ... ... Spitz DR, et al. O2(⋅-) and H2O2-Mediated Disruption of Fe Metabolism Causes the Differential Susceptibility of NSCLC and GBM Cancer Cells to Pharmacological Ascorbate. Cancer Cell. PMID 28366679 DOI: 10.1016/j.ccell.2017.02.018  1
2016 Zahra A, Chang T, Hejleh TA, Furqan M, Clamon GH, Bhatia SK, Watkins JM, Mott SL, Ahmann LL, Bodeker KL, Spitz DR, Buatti JM, Allen BG. Once Daily High-dose Radiation (≥60 Gy) Treatment in Limited Stage Small Cell Lung Cancer. Journal of Oncology Translational Research. 2. PMID 27981260  0.36
2016 Rodman SN, Spence JM, Ronnfeldt TJ, Zhu Y, Solst SR, O'Neill RA, Allen BG, Guan X, Spitz DR, Fath MA. Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin- and Glutathione-Dependent Metabolism. Radiation Research. PMID 27643875 DOI: 10.1667/RR14463.1  1
2016 Wongrakpanich A, Mudunkotuwa IA, Geary SM, Morris AS, Mapuskar KA, Spitz DR, Grassian VH, Salem AK. Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells. Environmental Science. Nano. 3: 365-374. PMID 27347420 DOI: 10.1039/C5EN00271K  0.56
2016 Klaren WD, Gibson-Corley KN, Wels B, Simmons DL, McCormick ML, Spitz DR, Robertson LW. Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity. Chemical Research in Toxicology. PMID 26967026 DOI: 10.1021/acs.chemrestox.6b00022  0.72
2016 Wongrakpanich A, Mudunkotuwa IA, Geary SM, Morris AS, Mapuskar KA, Spitz DR, Grassian VH, Salem AK. Size-dependent cytotoxicity of copper oxide nanoparticles in lung epithelial cells Environmental Science: Nano. 3: 365-374. DOI: 10.1039/c5en00271k  0.72
2015 Silvis AM, McCormick ML, Spitz DR, Kiningham KK. Redox balance influences differentiation status of neuroblastoma in the presence of all-trans retinoic acid. Redox Biology. 7: 88-96. PMID 26678800 DOI: 10.1016/j.redox.2015.11.012  0.72
2015 Welch DR, Antalis TM, Burnstein K, Vona-Davis L, Jensen RA, Nakshatri H, Riegel AT, Spitz DR, Watson DK, Weiner GJ. Essential Components of Cancer Education. Cancer Research. PMID 26627010 DOI: 10.1158/0008-5472.CAN-15-2077  0.72
2015 Rasmussen TP, Wu Y, Joiner ML, Koval OM, Wilson NR, Luczak ED, Wang Q, Chen B, Gao Z, Zhu Z, Wagner BA, Soto J, McCormick ML, Kutschke W, Weiss RM, ... ... Spitz DR, et al. Inhibition of MCU forces extramitochondrial adaptations governing physiological and pathological stress responses in heart. Proceedings of the National Academy of Sciences of the United States of America. 112: 9129-34. PMID 26153425 DOI: 10.1073/pnas.1504705112  1
2015 Hrabe JE, O'Leary BR, Fath MA, Rodman SN, Button AM, Domann FE, Spitz DR, Mezhir JJ. Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells. Redox Biology. 5: 319-327. PMID 26114584 DOI: 10.1016/j.redox.2015.06.004  1
2015 Du J, Cieslak JA, Welsh JL, Sibenaller ZA, Allen BG, Wagner BA, Kalen AL, Doskey CM, Strother RK, Button AM, Mott SL, Smith B, Tsai S, Mezhir J, Goswami PC, ... Spitz DR, et al. Pharmacological Ascorbate Radiosensitizes Pancreatic Cancer. Cancer Research. PMID 26081808 DOI: 10.1158/0008-5472.CAN-14-1707  0.72
2015 Bayer JL, Spitz DR, Christensen D, McCormick ML, Farley D, DeGeest K, Damoush L, Aust S, Sood AK, Lutgendorf SK. Biobehavioral and neuroendocrine correlates of antioxidant enzyme activity in ovarian carcinoma. Brain, Behavior, and Immunity. PMID 25989110 DOI: 10.1016/j.bbi.2015.04.019  1
2015 O'Leary BR, Fath MA, Bellizzi AM, Hrabe JE, Button AM, Allen BG, Case AJ, Altekruse S, Wagner BA, Buettner GR, Lynch CF, Hernandez BY, Cozen W, Beardsley RA, Keene J, ... ... Spitz DR, et al. Loss of SOD3 (EcSOD) Expression Promotes an Aggressive Phenotype in Human Pancreatic Ductal Adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1741-51. PMID 25634994 DOI: 10.1158/1078-0432.CCR-14-1959  1
2015 Li L, Fath MA, Scarbrough PM, Watson WH, Spitz DR. Combined inhibition of glycolysis, the pentose cycle, and thioredoxin metabolism selectively increases cytotoxicity and oxidative stress in human breast and prostate cancer. Redox Biology. 4: 127-35. PMID 25560241 DOI: 10.1016/j.redox.2014.12.001  1
2014 Allen BG, Bhatia SK, Anderson CM, Eichenberger-Gilmore JM, Sibenaller ZA, Mapuskar KA, Schoenfeld JD, Buatti JM, Spitz DR, Fath MA. Ketogenic diets as an adjuvant cancer therapy: History and potential mechanism. Redox Biology. 2: 963-970. PMID 25460731 DOI: 10.1016/j.redox.2014.08.002  1
2014 Wegman-Points LJ, Teoh-Fitzgerald ML, Mao G, Zhu Y, Fath MA, Spitz DR, Domann FE. Retroviral-infection increases tumorigenic potential of MDA-MB-231 breast carcinoma cells by expanding an aldehyde dehydrogenase (ALDH1) positive stem-cell like population. Redox Biology. 2: 847-54. PMID 25009786 DOI: 10.1016/j.redox.2014.06.006  0.72
2014 Zhou D, Shao L, Spitz DR. Reactive oxygen species in normal and tumor stem cells. Advances in Cancer Research. 122: 1-67. PMID 24974178 DOI: 10.1016/B978-0-12-420117-0.00001-3  1
2014 Hall DD, Wu Y, Domann FE, Spitz DR, Anderson ME. Mitochondrial calcium uniporter activity is dispensable for MDA-MB-231 breast carcinoma cell survival. Plos One. 9: e96866. PMID 24802861 DOI: 10.1371/journal.pone.0096866  0.72
2014 Wongrakpanich A, Adamcakova-Dodd A, Xie W, Joshi VB, Mapuskar KA, Geary SM, Spitz DR, Thorne PS, Salem AK. The absence of CpG in plasmid DNA-chitosan polyplexes enhances transfection efficiencies and reduces inflammatory responses in murine lungs. Molecular Pharmaceutics. 11: 1022-31. PMID 24494979 DOI: 10.1021/mp400689r  0.72
2014 Spitz DR, Hauer-Jensen M. Ionizing radiation-induced responses: where free radical chemistry meets redox biology and medicine. Antioxidants & Redox Signaling. 20: 1407-9. PMID 24354361 DOI: 10.1089/ars.2013.5769  1
2014 Coleman MC, Olivier AK, Jacobus JA, Mapuskar KA, Mao G, Martin SM, Riley DP, Gius D, Spitz DR. Superoxide mediates acute liver injury in irradiated mice lacking sirtuin 3. Antioxidants & Redox Signaling. 20: 1423-35. PMID 23919724 DOI: 10.1089/ars.2012.5091  0.72
2013 Cyr AR, Brown KE, McCormick ML, Coleman MC, Case AJ, Watts GS, Futscher BW, Spitz DR, Domann FE. Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. Redox Biology. 1: 172-7. PMID 24024150 DOI: 10.1016/j.redox.2013.01.001  0.72
2013 Worthington KL, Adamcakova-Dodd A, Wongrakpanich A, Mudunkotuwa IA, Mapuskar KA, Joshi VB, Allan Guymon C, Spitz DR, Grassian VH, Thorne PS, Salem AK. Chitosan coating of copper nanoparticles reduces in vitro toxicity and increases inflammation in the lung. Nanotechnology. 24: 395101. PMID 24008224 DOI: 10.1088/0957-4484/24/39/395101  0.72
2013 Zhu Y, Mapuskar KA, Marek RF, Xu W, Lehmler HJ, Robertson LW, Hornbuckle KC, Spitz DR, Aykin-Burns N. A new player in environmentally induced oxidative stress: polychlorinated biphenyl congener, 3,3'-dichlorobiphenyl (PCB11). Toxicological Sciences : An Official Journal of the Society of Toxicology. 136: 39-50. PMID 23997111 DOI: 10.1093/toxsci/kft186  1
2013 Bey EA, Reinicke KE, Srougi MC, Varnes M, Anderson VE, Pink JJ, Li LS, Patel M, Cao L, Moore Z, Rommel A, Boatman M, Lewis C, Euhus DM, Bornmann WG, ... ... Spitz DR, et al. Catalase abrogates β-lapachone-induced PARP1 hyperactivation-directed programmed necrosis in NQO1-positive breast cancers Molecular Cancer Therapeutics. 12: 2110-2120. PMID 23883585 DOI: 10.1158/1535-7163.MCT-12-0962  0.72
2013 Jacobus JA, Duda CG, Coleman MC, Martin SM, Mapuskar K, Mao G, Smith BJ, Aykin-Burns N, Guida P, Gius D, Domann FE, Knudson CM, Spitz DR. Low-dose radiation-induced enhancement of thymic lymphomagenesis in Lck-Bax mice is dependent on LET and gender. Radiation Research. 180: 156-65. PMID 23819597 DOI: 10.1667/RR3293.1  0.72
2013 Xiao W, Zhu Y, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Selenoprotein P regulates 1-(4-Chlorophenyl)-benzo-2,5-quinone-induced oxidative stress and toxicity in human keratinocytes. Free Radical Biology & Medicine. 65: 70-7. PMID 23770201 DOI: 10.1016/j.freeradbiomed.2013.06.010  1
2013 Allen BG, Bhatia SK, Buatti JM, Brandt KE, Lindholm KE, Button AM, Szweda LI, Smith BJ, Spitz DR, Fath MA. Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 3905-13. PMID 23743570 DOI: 10.1158/1078-0432.CCR-12-0287  0.72
2012 Kim SY, Rhee JG, Song X, Prochownik EV, Spitz DR, Lee YJ. Breast cancer stem cell-like cells are more sensitive to ionizing radiation than non-stem cells: role of ATM. Plos One. 7: e50423. PMID 23185620 DOI: 10.1371/journal.pone.0050423  1
2012 Sobhakumari A, Love-Homan L, Fletcher EV, Martin SM, Parsons AD, Spitz DR, Knudson CM, Simons AL. Susceptibility of human head and neck cancer cells to combined inhibition of glutathione and thioredoxin metabolism. Plos One. 7: e48175. PMID 23118946 DOI: 10.1371/journal.pone.0048175  0.72
2012 Duru N, Fan M, Candas D, Menaa C, Liu HC, Nantajit D, Wen Y, Xiao K, Eldridge A, Chromy BA, Li S, Spitz DR, Lam KS, Wicha MS, Li JJ. HER2-associated radioresistance of breast cancer stem cells isolated from HER2-negative breast cancer cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6634-47. PMID 23091114 DOI: 10.1158/1078-0432.CCR-12-1436  0.72
2012 Zhu Y, Park SH, Ozden O, Kim HS, Jiang H, Vassilopoulos A, Spitz DR, Gius D. Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity. Free Radical Biology & Medicine. 53: 828-33. PMID 22732184 DOI: 10.1016/j.freeradbiomed.2012.06.020  1
2012 Tyra HM, Spitz DR, Rutkowski DT. Inhibition of fatty acid oxidation enhances oxidative protein folding and protects hepatocytes from endoplasmic reticulum stress. Molecular Biology of the Cell. 23: 811-9. PMID 22262455 DOI: 10.1091/mbc.E11-12-1011  1
2012 Kang MA, So EY, Simons AL, Spitz DR, Ouchi T. DNA damage induces reactive oxygen species generation through the H2AX-Nox1/Rac1 pathway. Cell Death & Disease. 3: e249. PMID 22237206 DOI: 10.1038/cddis.2011.134  1
2012 Osborn-Heaford HL, Ryan AJ, Murthy S, Racila AM, He C, Sieren JC, Spitz DR, Carter AB. Mitochondrial Rac1 GTPase import and electron transfer from cytochrome c are required for pulmonary fibrosis. The Journal of Biological Chemistry. 287: 3301-12. PMID 22157762 DOI: 10.1074/jbc.M111.308387  1
2012 Scarbrough PM, Mapuskar KA, Mattson DM, Gius D, Watson WH, Spitz DR. Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress. Free Radical Biology & Medicine. 52: 436-43. PMID 22100505 DOI: 10.1016/j.freeradbiomed.2011.10.493  1
2012 Owens KM, Aykin-Burns N, Dayal D, Coleman MC, Domann FE, Spitz DR. Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2(-•) and H2O2. Free Radical Biology & Medicine. 52: 160-6. PMID 22041456 DOI: 10.1016/j.freeradbiomed.2011.10.435  1
2012 Zagorodna O, Martin SM, Rutkowski DT, Kuwana T, Spitz DR, Knudson CM. 2-deoxyglucose-induced toxicity is regulated by Bcl-2 family members and is enhanced by antagonizing Bcl-2 in lymphoma cell lines. Oncogene. 31: 2738-49. PMID 21986940 DOI: 10.1038/onc.2011.454  0.72
2012 Goel A, Spitz DR, Weiner GJ. Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma. Journal of Cellular Biochemistry. 113: 419-25. PMID 21956712 DOI: 10.1002/jcb.23387  1
2011 He BJ, Joiner ML, Singh MV, Luczak ED, Swaminathan PD, Koval OM, Kutschke W, Allamargot C, Yang J, Guan X, Zimmerman K, Grumbach IM, Weiss RM, Spitz DR, Sigmund CD, et al. Oxidation of CaMKII determines the cardiotoxic effects of aldosterone. Nature Medicine. 17: 1610-8. PMID 22081025 DOI: 10.1038/nm.2506  0.72
2011 Park SH, Ozden O, Jiang H, Cha YI, Pennington JD, Aykin-Burns N, Spitz DR, Gius D, Kim HS. Sirt3, mitochondrial ROS, ageing, and carcinogenesis. International Journal of Molecular Sciences. 12: 6226-39. PMID 22016654 DOI: 10.3390/ijms12096226  0.72
2011 Fath MA, Ahmad IM, Smith CJ, Spence J, Spitz DR. Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 6206-17. PMID 21844013 DOI: 10.1158/1078-0432.CCR-11-0736  0.72
2011 Schickling BM, Aykin-Burns N, Leslie KK, Spitz DR, Korovkina VP. An inhibitor of K+ channels modulates human endometrial tumor-initiating cells. Cancer Cell International. 11: 25. PMID 21810252 DOI: 10.1186/1475-2867-11-25  1
2011 Spitz DR. Metabolic oxidative stress and low dose radiation responses: are mitochondria involved. Health Physics. 100: 295. PMID 21595073  1
2011 Orcutt KP, Parsons AD, Sibenaller ZA, Scarbrough PM, Zhu Y, Sobhakumari A, Wilke WW, Kalen AL, Goswami P, Miller FJ, Spitz DR, Simons AL. Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. Cancer Research. 71: 3932-40. PMID 21482679 DOI: 10.1158/0008-5472.CAN-10-3425  1
2011 Cullen JJ, Spitz DR, Buettner GR. Comment on "Pharmacologic ascorbate synergizes with gemcitabine in preclinical models of pancreatic cancer," i.e., all we are saying is, give C a chance. Free Radical Biology & Medicine. 50: 1726-7. PMID 21459141 DOI: 10.1016/j.freeradbiomed.2011.03.030  1
2011 He C, Murthy S, McCormick ML, Spitz DR, Ryan AJ, Carter AB. Mitochondrial Cu,Zn-superoxide dismutase mediates pulmonary fibrosis by augmenting H2O2 generation. The Journal of Biological Chemistry. 286: 15597-607. PMID 21393238 DOI: 10.1074/jbc.M110.187377  0.72
2011 Ozden O, Park SH, Kim HS, Jiang H, Coleman MC, Spitz DR, Gius D. Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging. 3: 102-7. PMID 21386137  1
2011 Aykin-Burns N, Slane BG, Liu AT, Owens KM, O'Malley MS, Smith BJ, Domann FE, Spitz DR. Sensitivity to low-dose/low-LET ionizing radiation in mammalian cells harboring mutations in succinate dehydrogenase subunit C is governed by mitochondria-derived reactive oxygen species. Radiation Research. 175: 150-8. PMID 21268708 DOI: 10.1667/RR2220.1  1
2011 Case AJ, McGill JL, Tygrett LT, Shirasawa T, Spitz DR, Waldschmidt TJ, Legge KL, Domann FE. Elevated mitochondrial superoxide disrupts normal T cell development, impairing adaptive immune responses to an influenza challenge. Free Radical Biology & Medicine. 50: 448-58. PMID 21130157 DOI: 10.1016/j.freeradbiomed.2010.11.025  1
2011 Westin ER, Aykin-Burns N, Buckingham EM, Spitz DR, Goldman FD, Klingelhutz AJ. The p53/p21(WAF/CIP) pathway mediates oxidative stress and senescence in dyskeratosis congenita cells with telomerase insufficiency. Antioxidants & Redox Signaling. 14: 985-97. PMID 21087144 DOI: 10.1089/ars.2010.3444  1
2010 Tao R, Coleman MC, Pennington JD, Ozden O, Park SH, Jiang H, Kim HS, Flynn CR, Hill S, Hayes McDonald W, Olivier AK, Spitz DR, Gius D. Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress. Molecular Cell. 40: 893-904. PMID 21172655 DOI: 10.1016/j.molcel.2010.12.013  0.72
2010 Bera S, Greiner S, Choudhury A, Dispenzieri A, Spitz DR, Russell SJ, Goel A. Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis. Neoplasia (New York, N.Y.). 12: 980-92. PMID 21170263 DOI: 10.1593/neo.101146  1
2010 Fitzgerald MP, Madsen JM, Coleman MC, Teoh ML, Westphal SG, Spitz DR, Radi R, Domann FE. Transgenic biosynthesis of trypanothione protects Escherichia coli from radiation-induced toxicity. Radiation Research. 174: 290-6. PMID 20726720 DOI: 10.1667/RR2235.1  1
2010 Tan M, Zhu Y, Kovacev J, Zhao Y, Pan ZQ, Spitz DR, Sun Y. Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells. Free Radical Biology & Medicine. 49: 976-83. PMID 20638939 DOI: 10.1016/j.freeradbiomed.2010.05.030  0.72
2010 Sun WG, Weydert CJ, Zhang Y, Yu L, Liu J, Spitz DR, Cullen JJ, Oberley LW. Superoxide Enhances the Antitumor Combination of AdMnSOD Plus BCNU in Breast Cancer. Cancers. 2: 68-87. PMID 20532186 DOI: 10.3390/cancers2010068  1
2010 Shutt DC, O'Dorisio MS, Aykin-Burns N, Spitz DR. 2-deoxy-D-glucose induces oxidative stress and cell killing in human neuroblastoma cells. Cancer Biology & Therapy. 9: 853-61. PMID 20364116 DOI: 10.4161/cbt.9.11.11632  1
2010 Chaudhuri L, Sarsour EH, Kalen AL, Aykin-Burns N, Spitz DR, Goswami PC. Polychlorinated biphenyl induced ROS signaling delays the entry of quiescent human breast epithelial cells into the proliferative cycle. Free Radical Biology & Medicine. 49: 40-9. PMID 20307652 DOI: 10.1016/j.freeradbiomed.2010.03.012  1
2010 Solazzo SA, Ahmed M, Schor-Bardach R, Yang W, Girnun GD, Rahmanuddin S, Levchenko T, Signoretti S, Spitz DR, Torchilin V, Goldberg SN. Liposomal doxorubicin increases radiofrequency ablation-induced tumor destruction by increasing cellular oxidative and nitrative stress and accelerating apoptotic pathways. Radiology. 255: 62-74. PMID 20160000 DOI: 10.1148/radiol.09091196  0.72
2010 Kim HS, Patel K, Muldoon-Jacobs K, Bisht KS, Aykin-Burns N, Pennington JD, van der Meer R, Nguyen P, Savage J, Owens KM, Vassilopoulos A, Ozden O, Park SH, Singh KK, Abdulkadir SA, ... Spitz DR, et al. SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress. Cancer Cell. 17: 41-52. PMID 20129246 DOI: 10.1016/j.ccr.2009.11.023  1
2010 Hadzic T, Aykin-Burns N, Zhu Y, Coleman MC, Leick K, Jacobson GM, Spitz DR. Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress. Free Radical Biology & Medicine. 48: 1024-33. PMID 20083194 DOI: 10.1016/j.freeradbiomed.2010.01.018  1
2010 Spitz DR, Sullivan SJ. The generation of stable oxidative stress-resistant phenotypes in Chinese hamster fibroblasts chronically exposed to hydrogen peroxide or hyperoxia. Methods in Molecular Biology (Clifton, N.J.). 610: 183-99. PMID 20013179 DOI: 10.1007/978-1-60327-029-8_11  1
2009 Simons AL, Mattson DM, Dornfeld K, Spitz DR. Glucose deprivation-induced metabolic oxidative stress and cancer therapy. Journal of Cancer Research and Therapeutics. 5: S2-6. PMID 20009288 DOI: 10.4103/0973-1482.55133  1
2009 Dayal D, Martin SM, Owens KM, Aykin-Burns N, Zhu Y, Boominathan A, Pain D, Limoli CL, Goswami PC, Domann FE, Spitz DR. Mitochondrial complex II dysfunction can contribute significantly to genomic instability after exposure to ionizing radiation. Radiation Research. 172: 737-45. PMID 19929420 DOI: 10.1667/RR1617.1  1
2009 Zhu Y, Kalen AL, Li L, Lehmler HJ, Robertson LW, Goswami PC, Spitz DR, Aykin-Burns N. Polychlorinated-biphenyl-induced oxidative stress and cytotoxicity can be mitigated by antioxidants after exposure. Free Radical Biology & Medicine. 47: 1762-71. PMID 19796678 DOI: 10.1016/j.freeradbiomed.2009.09.024  1
2009 Simons AL, Parsons AD, Foster KA, Orcutt KP, Fath MA, Spitz DR. Inhibition of glutathione and thioredoxin metabolism enhances sensitivity to perifosine in head and neck cancer cells. Journal of Oncology. 2009: 519563. PMID 19746172 DOI: 10.1155/2009/519563  1
2009 Du C, Gao Z, Venkatesha VA, Kalen AL, Chaudhuri L, Spitz DR, Cullen JJ, Oberley LW, Goswami PC. Mitochondrial ROS and radiation induced transformation in mouse embryonic fibroblasts. Cancer Biology & Therapy. 8: 1962-71. PMID 19738419 DOI: 10.4161/cbt.8.20.9648  1
2009 Holley AK, Kiningham KK, Spitz DR, Edwards DP, Jenkins JT, Moore MR. Progestin stimulation of manganese superoxide dismutase and invasive properties in T47D human breast cancer cells. The Journal of Steroid Biochemistry and Molecular Biology. 117: 23-30. PMID 19563893 DOI: 10.1016/j.jsbmb.2009.06.004  1
2009 Xie W, Wu Q, Kania-Korwel I, Tharappel JC, Telu S, Coleman MC, Glauert HP, Kannan K, Mariappan SV, Spitz DR, Weydert J, Lehmler HJ. Subacute exposure to N-ethyl perfluorooctanesulfonamidoethanol results in the formation of perfluorooctanesulfonate and alters superoxide dismutase activity in female rats. Archives of Toxicology. 83: 909-24. PMID 19544052 DOI: 10.1007/s00204-009-0450-y  1
2009 Gupta AK, Lee JH, Wilke WW, Quon H, Smith G, Maity A, Buatti JM, Spitz DR. Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT. International Journal of Radiation Oncology, Biology, Physics. 74: 928-33. PMID 19480971 DOI: 10.1016/j.ijrobp.2009.03.004  1
2009 Fath MA, Diers AR, Aykin-Burns N, Simons AL, Hua L, Spitz DR. Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells. Cancer Biology & Therapy. 8: 1228-36. PMID 19411865  1
2009 Grdina DJ, Murley JS, Kataoka Y, Baker KL, Kunnavakkam R, Coleman MC, Spitz DR. Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. International Journal of Radiation Oncology, Biology, Physics. 73: 886-96. PMID 19215822 DOI: 10.1016/j.ijrobp.2008.10.061  1
2009 Lamkin DM, Spitz DR, Shahzad MM, Zimmerman B, Lenihan DJ, Degeest K, Lubaroff DM, Shinn EH, Sood AK, Lutgendorf SK. Glucose as a prognostic factor in ovarian carcinoma. Cancer. 115: 1021-7. PMID 19156916 DOI: 10.1002/cncr.24126  1
2009 Haak JL, Buettner GR, Spitz DR, Kregel KC. Aging augments mitochondrial susceptibility to heat stress. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R812-20. PMID 19144753 DOI: 10.1152/ajpregu.90708.2008  1
2009 von Bergen NH, Koppenhafer SL, Spitz DR, Volk KA, Patel SS, Roghair RD, Lamb FS, Segar JL, Scholz TD. Fetal programming alters reactive oxygen species production in sheep cardiac mitochondria. Clinical Science (London, England : 1979). 116: 659-68. PMID 19032144 DOI: 10.1042/CS20080474  1
2009 Nyunoya T, Monick MM, Klingelhutz AL, Glaser H, Cagley JR, Brown CO, Matsumoto E, Aykin-Burns N, Spitz DR, Oshima J, Hunninghake GW. Cigarette smoke induces cellular senescence via Werner's syndrome protein down-regulation. American Journal of Respiratory and Critical Care Medicine. 179: 279-87. PMID 19011155 DOI: 10.1164/rccm.200802-320OC  1
2009 Mattson DM, Ahmad IM, Dayal D, Parsons AD, Aykin-Burns N, Li L, Orcutt KP, Spitz DR, Dornfeld KJ, Simons AL. Cisplatin combined with zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol-dependent mechanism. Free Radical Biology & Medicine. 46: 232-7. PMID 18983911 DOI: 10.1016/j.freeradbiomed.2008.10.023  1
2009 Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR. Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. The Biochemical Journal. 418: 29-37. PMID 18937644 DOI: 10.1042/BJ20081258  1
2008 Dziegielewski J, Baulch JE, Goetz W, Coleman MC, Spitz DR, Murley JS, Grdina DJ, Morgan WF. WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free Radical Biology & Medicine. 45: 1674-81. PMID 18845240 DOI: 10.1016/j.freeradbiomed.2008.09.004  1
2008 Jacobs KM, Pennington JD, Bisht KS, Aykin-Burns N, Kim HS, Mishra M, Sun L, Nguyen P, Ahn BH, Leclerc J, Deng CX, Spitz DR, Gius D. SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression. International Journal of Biological Sciences. 4: 291-9. PMID 18781224  1
2008 Smith-Pearson PS, Kooshki M, Spitz DR, Poole LB, Zhao W, Robbins ME. Decreasing peroxiredoxin II expression decreases glutathione, alters cell cycle distribution, and sensitizes glioma cells to ionizing radiation and H(2)O(2). Free Radical Biology & Medicine. 45: 1178-89. PMID 18718523 DOI: 10.1016/j.freeradbiomed.2008.07.015  1
2008 Monick MM, Powers LS, Barrett CW, Hinde S, Ashare A, Groskreutz DJ, Nyunoya T, Coleman M, Spitz DR, Hunninghake GW. Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity. Journal of Immunology (Baltimore, Md. : 1950). 180: 7485-96. PMID 18490749  1
2008 Erickson JR, Joiner ML, Guan X, Kutschke W, Yang J, Oddis CV, Bartlett RK, Lowe JS, O'Donnell SE, Aykin-Burns N, Zimmerman MC, Zimmerman K, Ham AJ, Weiss RM, Spitz DR, et al. A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation. Cell. 133: 462-74. PMID 18455987 DOI: 10.1016/j.cell.2008.02.048  1
2008 Dong LF, Low P, Dyason JC, Wang XF, Prochazka L, Witting PK, Freeman R, Swettenham E, Valis K, Liu J, Zobalova R, Turanek J, Spitz DR, Domann FE, Scheffler IE, et al. α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II Oncogene. 27: 4324-4335. PMID 18372923 DOI: 10.1038/onc.2008.69  1
2008 Dayal D, Martin SM, Limoli CL, Spitz DR. Hydrogen peroxide mediates the radiation-induced mutator phenotype in mammalian cells. The Biochemical Journal. 413: 185-91. PMID 18352860 DOI: 10.1042/BJ20071643  1
2008 van de Wetering CI, Coleman MC, Spitz DR, Smith BJ, Knudson CM. Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma. Free Radical Biology & Medicine. 44: 1677-86. PMID 18291119 DOI: 10.1016/j.freeradbiomed.2008.01.022  1
2008 Kiningham KK, Cardozo ZA, Cook C, Cole MP, Stewart JC, Tassone M, Coleman MC, Spitz DR. All-trans-retinoic acid induces manganese superoxide dismutase in human neuroblastoma through NF-kappaB. Free Radical Biology & Medicine. 44: 1610-6. PMID 18280257 DOI: 10.1016/j.freeradbiomed.2008.01.015  1
2008 Coleman MC, Asbury CR, Daniels D, Du J, Aykin-Burns N, Smith BJ, Li L, Spitz DR, Cullen JJ. 2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer. Free Radical Biology & Medicine. 44: 322-31. PMID 18215740 DOI: 10.1016/j.freeradbiomed.2007.08.032  1
2008 Dornfeld K, Hopkins S, Simmons J, Spitz DR, Menda Y, Graham M, Smith R, Funk G, Karnell L, Karnell M, Dornfeld M, Yao M, Buatti J. Posttreatment FDG-PET uptake in the supraglottic and glottic larynx correlates with decreased quality of life after chemoradiotherapy. International Journal of Radiation Oncology, Biology, Physics. 71: 386-92. PMID 18164842 DOI: 10.1016/j.ijrobp.2007.09.052  1
2008 Weydert CJ, Zhang Y, Sun W, Waugh TA, Teoh ML, Andringa KK, Aykin-Burns N, Spitz DR, Smith BJ, Oberley LW. Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth. Free Radical Biology & Medicine. 44: 856-67. PMID 18155673 DOI: 10.1016/j.freeradbiomed.2007.11.009  1
2008 Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, Oberley LW, Domann FE, Spitz DR. 2-Deoxyglucose combined with wild-type p53 overexpression enhances cytotoxicity in human prostate cancer cells via oxidative stress. Free Radical Biology & Medicine. 44: 826-34. PMID 18155176 DOI: 10.1016/j.freeradbiomed.2007.11.007  1
2008 Venkatachalam P, De Toledo SM, Pandey BN, Tephly LA, Carter AB, Little JB, Spitz DR, Azzam EI. Regulation of normal cell cycle progression by flavin-containing oxidases Oncogene. 27: 20-31. PMID 17637756 DOI: 10.1038/sj.onc.1210634  1
2007 Simons AL, Fath MA, Mattson DM, Smith BJ, Walsh SA, Graham MM, Hichwa RD, Buatti JM, Dornfeld K, Spitz DR. Enhanced response of human head and neck cancer xenograft tumors to cisplatin combined with 2-deoxy-D-glucose correlates with increased 18F-FDG uptake as determined by PET imaging. International Journal of Radiation Oncology, Biology, Physics. 69: 1222-30. PMID 17967311 DOI: 10.1016/j.ijrobp.2007.07.2343  1
2007 Simons AL, Ahmad IM, Mattson DM, Dornfeld KJ, Spitz DR. 2-Deoxy-D-glucose combined with cisplatin enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells. Cancer Research. 67: 3364-70. PMID 17409446 DOI: 10.1158/0008-5472.CAN-06-3717  1
2007 Fan M, Ahmed KM, Coleman MC, Spitz DR, Li JJ. Nuclear factor-kappaB and manganese superoxide dismutase mediate adaptive radioresistance in low-dose irradiated mouse skin epithelial cells. Cancer Research. 67: 3220-8. PMID 17409430 DOI: 10.1158/0008-5472.CAN-06-2728  1
2007 Smith PS, Zhao W, Spitz DR, Robbins ME. Inhibiting catalase activity sensitizes 36B10 rat glioma cells to oxidative stress. Free Radical Biology & Medicine. 42: 787-97. PMID 17320761 DOI: 10.1016/j.freeradbiomed.2006.11.032  1
2007 Brown KE, Meleah Mathahs M, Broadhurst KA, Coleman MC, Ridnour LA, Schmidt WN, Spitz DR. Increased hepatic telomerase activity in a rat model of iron overload: a role for altered thiol redox state? Free Radical Biology & Medicine. 42: 228-35. PMID 17189828 DOI: 10.1016/j.freeradbiomed.2006.10.039  1
2006 de Toledo SM, Asaad N, Venkatachalam P, Li L, Howell RW, Spitz DR, Azzam EI. Adaptive responses to low-dose/low-dose-rate gamma rays in normal human fibroblasts: the role of growth architecture and oxidative metabolism. Radiation Research. 166: 849-57. PMID 17149977 DOI: 10.1667/RR0640.1  1
2006 Yu L, Venkataraman S, Coleman MC, Spitz DR, Wertz PW, Domann FE. Glutathione peroxidase-1 inhibits UVA-induced AP-2alpha expression in human keratinocytes. Biochemical and Biophysical Research Communications. 351: 1066-71. PMID 17097614 DOI: 10.1016/j.bbrc.2006.10.171  1
2006 Du J, Daniels DH, Asbury C, Venkataraman S, Liu J, Spitz DR, Oberley LW, Cullen JJ. Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells. The Journal of Biological Chemistry. 281: 37416-26. PMID 17040906 DOI: 10.1074/jbc.M605063200  1
2006 Bentle MS, Reinicke KE, Bey EA, Spitz DR, Boothman DA. Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. The Journal of Biological Chemistry. 281: 33684-96. PMID 16920718 DOI: 10.1074/jbc.M603678200  1
2006 Luo J, Li L, Zhang Y, Spitz DR, Buettner GR, Oberley LW, Domann FE. Inactivation of primary antioxidant enzymes in mouse keratinocytes by photodynamically generated singlet oxygen. Antioxidants & Redox Signaling. 8: 1307-14. PMID 16910778 DOI: 10.1089/ars.2006.8.1307  1
2006 Gius D, Spitz DR. Redox signaling in cancer biology. Antioxidants & Redox Signaling. 8: 1249-52. PMID 16910772 DOI: 10.1089/ars.2006.8.1249  1
2006 Slane BG, Aykin-Burns N, Smith BJ, Kalen AL, Goswami PC, Domann FE, Spitz DR. Mutation of succinate dehydrogenase subunit C results in increased O2.-, oxidative stress, and genomic instability. Cancer Research. 66: 7615-20. PMID 16885361 DOI: 10.1158/0008-5472.CAN-06-0833  1
2006 Weydert CJ, Waugh TA, Ritchie JM, Iyer KS, Smith JL, Li L, Spitz DR, Oberley LW. Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth. Free Radical Biology & Medicine. 41: 226-37. PMID 16814103 DOI: 10.1016/j.freeradbiomed.2006.03.015  1
2006 Coyle CH, Martinez LJ, Coleman MC, Spitz DR, Weintraub NL, Kader KN. Mechanisms of H2O2-induced oxidative stress in endothelial cells. Free Radical Biology & Medicine. 40: 2206-13. PMID 16785034 DOI: 10.1016/j.freeradbiomed.2006.02.017  1
2006 Andringa KK, Coleman MC, Aykin-Burns N, Hitchler MJ, Walsh SA, Domann FE, Spitz DR. Inhibition of glutamate cysteine ligase activity sensitizes human breast cancer cells to the toxicity of 2-deoxy-D-glucose. Cancer Research. 66: 1605-10. PMID 16452219 DOI: 10.1158/0008-5472.CAN-05-3462  1
2006 Laszlo A, Davidson T, Harvey A, Sim JE, Malyapa RS, Spitz DR, Roti Roti JL. Alterations in heat-induced radiosensitization accompanied by nuclear structure alterations in Chinese hamster cells. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 22: 43-60. PMID 16423752 DOI: 10.1080/02656730500394296  1
2006 Nguyen P, Awwad RT, Smart DD, Spitz DR, Gius D. Thioredoxin reductase as a novel molecular target for cancer therapy. Cancer Letters. 236: 164-74. PMID 15955621 DOI: 10.1016/j.canlet.2005.04.028  1
2005 Hadzic T, Li L, Cheng N, Walsh SA, Spitz DR, Knudson CM. The role of low molecular weight thiols in T lymphocyte proliferation and IL-2 secretion. Journal of Immunology (Baltimore, Md. : 1950). 175: 7965-72. PMID 16339532  1
2005 Vasilyev N, Williams T, Brennan ML, Unzek S, Zhou X, Heinecke JW, Spitz DR, Topol EJ, Hazen SL, Penn MS. Myeloperoxidase-generated oxidants modulate left ventricular remodeling but not infarct size after myocardial infarction. Circulation. 112: 2812-20. PMID 16267254 DOI: 10.1161/CIRCULATIONAHA.105.542340  1
2005 Wang M, Kirk JS, Venkataraman S, Domann FE, Zhang HJ, Schafer FQ, Flanagan SW, Weydert CJ, Spitz DR, Buettner GR, Oberley LW. Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene. 24: 8154-66. PMID 16170370 DOI: 10.1038/sj.onc.1208986  1
2005 Harrison JF, Hollensworth SB, Spitz DR, Copeland WC, Wilson GL, LeDoux SP. Oxidative stress-induced apoptosis in neurons correlates with mitochondrial DNA base excision repair pathway imbalance. Nucleic Acids Research. 33: 4660-71. PMID 16107556 DOI: 10.1093/nar/gki759  1
2005 Morrison JP, Coleman MC, Aunan ES, Walsh SA, Spitz DR, Kregel KC. Thiol supplementation in aged animals alters antioxidant enzyme activity after heat stress. Journal of Applied Physiology (Bethesda, Md. : 1985). 99: 2271-7. PMID 16099896 DOI: 10.1152/japplphysiol.00412.2005  1
2005 Reszka KJ, Wagner BA, Teesch LM, Britigan BE, Spitz DR, Burns CP. Inactivation of anthracyclines by cellular peroxidase. Cancer Research. 65: 6346-53. PMID 16024637 DOI: 10.1158/0008-5472.CAN-04-2312  1
2005 Abdalla MY, Ahmad IM, Spitz DR, Schmidt WN, Britigan BE. Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. Journal of Medical Virology. 76: 489-97. PMID 15977232 DOI: 10.1002/jmv.20388  1
2005 Morrison JP, Coleman MC, Aunan ES, Walsh SA, Spitz DR, Kregel KC. Aging reduces responsiveness to BSO- and heat stress-induced perturbations of glutathione and antioxidant enzymes. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 289: R1035-41. PMID 15947071 DOI: 10.1152/ajpregu.00254.2005  1
2005 Menon SG, Coleman MC, Walsh SA, Spitz DR, Goswami PC. Differential susceptibility of nonmalignant human breast epithelial cells and breast cancer cells to thiol antioxidant-induced G(1)-delay. Antioxidants & Redox Signaling. 7: 711-8. PMID 15890017 DOI: 10.1089/ars.2005.7.711  1
2005 Ridnour LA, Sim JE, Choi J, Dickinson DA, Forman HJ, Ahmad IM, Coleman MC, Hunt CR, Goswami PC, Spitz DR. Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process. Free Radical Biology & Medicine. 38: 1361-71. PMID 15855054 DOI: 10.1016/j.freeradbiomed.2005.01.023  1
2005 Grishko VI, Rachek LI, Spitz DR, Wilson GL, LeDoux SP. Contribution of mitochondrial DNA repair to cell resistance from oxidative stress. The Journal of Biological Chemistry. 280: 8901-5. PMID 15632148 DOI: 10.1074/jbc.M413022200  1
2005 Ahmad IM, Aykin-Burns N, Sim JE, Walsh SA, Higashikubo R, Buettner GR, Venkataraman S, Mackey MA, Flanagan SW, Oberley LW, Spitz DR. Mitochondrial O2*- and H2O2 mediate glucose deprivation-induced stress in human cancer cells. The Journal of Biological Chemistry. 280: 4254-63. PMID 15561720 DOI: 10.1074/jbc.M411662200  1
2004 Hook GJ, Spitz DR, Sim JE, Higashikubo R, Baty JD, Moros EG, Roti Roti JL. Evaluation of parameters of oxidative stress after in vitro exposure to FMCW- and CDMA-modulated radiofrequency radiation fields. Radiation Research. 162: 497-504. PMID 15624304 DOI: 10.1667/RR3251  1
2004 Ozeki M, Tamae D, Hou DX, Wang T, Lebon T, Spitz DR, Li JJ. Response of cyclin B1 to ionizing radiation: regulation by NF-kappaB and mitochondrial antioxidant enzyme MnSOD. Anticancer Research. 24: 2657-63. PMID 15517870  1
2004 Lewis A, Ough M, Li L, Hinkhouse MM, Ritchie JM, Spitz DR, Cullen JJ. Treatment of pancreatic cancer cells with dicumarol induces cytotoxicity and oxidative stress. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 4550-8. PMID 15240547 DOI: 10.1158/1078-0432.CCR-03-0667  1
2004 Spitz DR, Azzam EI, Li JJ, Gius D. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Reviews. 23: 311-22. PMID 15197331 DOI: 10.1023/B:CANC.0000031769.14728.bc  1
2004 Mattson D, Bradbury CM, Bisht KS, Curry HA, Spitz DR, Gius D. Heat shock and the activation of AP-1 and inhibition of NF-kappa B DNA-binding activity: possible role of intracellular redox status. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 20: 224-33. PMID 15195516 DOI: 10.1080/02656730310001619956  1
2004 Gius D, Mattson D, Bradbury CM, Smart DK, Spitz DR. Thermal stress and the disruption of redox-sensitive signalling and transcription factor activation: Possible role in radiosensitization International Journal of Hyperthermia. 20: 213-223. PMID 15195515 DOI: 10.1080/02656730310001619505  1
2004 O'Malley YQ, Reszka KJ, Spitz DR, Denning GM, Britigan BE. Pseudomonas aeruginosa pyocyanin directly oxidizes glutathione and decreases its levels in airway epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology. 287: L94-103. PMID 15020296 DOI: 10.1152/ajplung.00025.2004  1
2004 Carter AB, Tephly LA, Venkataraman S, Oberley LW, Zhang Y, Buettner GR, Spitz DR, Hunninghake GW. High levels of catalase and glutathione peroxidase activity dampen H2O2 signaling in human alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology. 31: 43-53. PMID 14962975 DOI: 10.1165/rcmb.2003-0377OC  1
2004 Wen F, Abdalla MY, Aloman C, Xiang J, Ahmad IM, Walewski J, McCormick ML, Brown KE, Branch AD, Spitz DR, Britigan BE, Schmidt WN. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. Journal of Medical Virology. 72: 230-40. PMID 14695664 DOI: 10.1002/jmv.10567  1
2003 Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW. Intracellular thiols contribute to Th2 function via a positive role in IL-4 production. Journal of Immunology (Baltimore, Md. : 1950). 171: 5107-15. PMID 14607909  1
2003 Brown KE, Dennery PA, Ridnour LA, Fimmel CJ, Kladney RD, Brunt EM, Spitz DR. Effect of iron overload and dietary fat on indices of oxidative stress and hepatic fibrogenesis in rats. Liver International : Official Journal of the International Association For the Study of the Liver. 23: 232-42. PMID 12895262  1
2003 Lee YJ, Song YK, Song JJ, Siervo-Sassi RR, Kim HR, Li L, Spitz DR, Lokshin A, Kim JH. Reconstitution of galectin-3 alters glutathione content and potentiates TRAIL-induced cytotoxicity by dephosphorylation of Akt. Experimental Cell Research. 288: 21-34. PMID 12878156 DOI: 10.1016/S0014-4827(03)00211-8  1
2003 Lin X, Zhang F, Bradbury CM, Kaushal A, Li L, Spitz DR, Aft RL, Gius D. 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism. Cancer Research. 63: 3413-7. PMID 12810678  1
2003 Menon SG, Sarsour EH, Spitz DR, Higashikubo R, Sturm M, Zhang H, Goswami PC. Redox regulation of the G1 to S phase transition in the mouse embryo fibroblast cell cycle. Cancer Research. 63: 2109-17. PMID 12727827  1
2003 Narushima S, Spitz DR, Oberley LW, Toyokuni S, Miyata T, Gunnett CA, Buettner GR, Zhang J, Ismail H, Lynch RG, Berg DJ. Evidence for oxidative stress in NSAID-induced colitis in IL10-/- mice. Free Radical Biology & Medicine. 34: 1153-66. PMID 12706496 DOI: 10.1016/S0891-5849(03)00065-0  1
2003 Guo G, Yan-Sanders Y, Lyn-Cook BD, Wang T, Tamae D, Ogi J, Khaletskiy A, Li Z, Weydert C, Longmate JA, Huang TT, Spitz DR, Oberley LW, Li JJ. Manganese superoxide dismutase-mediated gene expression in radiation-induced adaptive responses. Molecular and Cellular Biology. 23: 2362-78. PMID 12640121 DOI: 10.1128/MCB.23.7.2362-2378.2003  1
2002 Borrelli MJ, Bernock LJ, Landry J, Spitz DR, Weber LA, Hickey E, Freeman ML, Corry PM. Stress protection by a fluorescent Hsp27 chimera that is independent of nuclear translocation or multimeric dissociation. Cell Stress & Chaperones. 7: 281-96. PMID 12482204 DOI: 10.1379/1466-1268(2002)007<0281:SPBAFH>2.0.CO;2  1
2002 Kirsch JD, Yi AK, Spitz DR, Krieg AM. Accumulation of glutathione disulfide mediates NF-kappaB activation during immune stimulation with CpG DNA. Antisense & Nucleic Acid Drug Development. 12: 327-40. PMID 12477282 DOI: 10.1089/108729002761381302  1
2002 Zimmerman MC, Lazartigues E, Lang JA, Sinnayah P, Ahmad IM, Spitz DR, Davisson RL. Superoxide mediates the actions of angiotensin II in the central nervous system. Circulation Research. 91: 1038-45. PMID 12456490 DOI: 10.1161/01.RES.0000043501.47934.FA  1
2002 Azzam EI, De Toledo SM, Spitz DR, Little JB. Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from alpha-particle-irradiated normal human fibroblast cultures. Cancer Research. 62: 5436-42. PMID 12359750  1
2002 Song JJ, Rhee JG, Suntharalingam M, Walsh SA, Spitz DR, Lee YJ. Role of glutaredoxin in metabolic oxidative stress. Glutaredoxin as a sensor of oxidative stress mediated by H2O2. The Journal of Biological Chemistry. 277: 46566-75. PMID 12244106 DOI: 10.1074/jbc.M206826200  1
2002 Karimpour S, Lou J, Lin LL, Rene LM, Lagunas L, Ma X, Karra S, Bradbury CM, Markovina S, Goswami PC, Spitz DR, Hirota K, Kalvakolanu DV, Yodoi J, Gius D. Thioredoxin reductase regulates AP-1 activity as well as thioredoxin nuclear localization via active cysteines in response to ionizing radiation. Oncogene. 21: 6317-27. PMID 12214272 DOI: 10.1038/sj.onc.1205749  1
2002 Suzuki T, Spitz DR, Gandhi P, Lin HY, Crawford DR. Mammalian resistance to oxidative stress: a comparative analysis. Gene Expression. 10: 179-91. PMID 12173744  1
2002 Goswami PC, Higashikubo R, Spitz DR. Redox control of cell cycle-coupled topoisomerase II alpha gene expression. Methods in Enzymology. 353: 448-59. PMID 12078518 DOI: 10.1016/S0076-6879(02)53068-8  1
2002 VanderWaal RP, Spitz DR, Griffith CL, Higashikubo R, Roti Roti JL. Evidence that protein disulfide isomerase (PDI) is involved in DNA-nuclear matrix anchoring. Journal of Cellular Biochemistry. 85: 689-702. PMID 11968009 DOI: 10.1002/jcb.10169  1
2002 Sekhar KR, Spitz DR, Harris S, Nguyen TT, Meredith MJ, Holt JT, Gius D, Marnett LJ, Summar ML, Freeman ML, Guis D. Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase. Free Radical Biology & Medicine. 32: 650-62. PMID 11909699 DOI: 10.1016/S0891-5849(02)00755-4  1
2001 Spitz DR, Oberley LW. Measurement of MnSOD and CuZnSOD activity in mammalian tissue homogenates Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. PMID 20954153  1
2001 Zhao W, Spitz DR, Oberley LW, Robbins ME. Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation. Cancer Research. 61: 5537-43. PMID 11454704  1
2001 Li WG, Miller FJ, Zhang HJ, Spitz DR, Oberley LW, Weintraub NL. H2O2-induced O2.- Production by a Non-phagocytic NAD(P)H Oxidase Causes Oxidant Injury Journal of Biological Chemistry. 276: 29251-29256. PMID 11358965 DOI: 10.1074/jbc.M102124200  1
2001 Bradbury CM, Locke JE, Wei SJ, Rene LM, Karimpour S, Hunt C, Spitz DR, Gius D. Increased activator protein 1 activity as well as resistance to heat-induced radiosensitization, hydrogen peroxide, and cisplatin are inhibited by indomethacin in oxidative stress-resistant cells Cancer Research. 61: 3486-3492. PMID 11309312  1
2001 Lee YJ, Chen JC, Amoscato AA, Bennouna J, Spitz DR, Suntharalingam M, Rhee JG. Protective role in Bcl2 in metabolic oxidative stress-induced cell death Journal of Cell Science. 114: 677-684. PMID 11171373  1
2001 VanderWaal RP, Higashikubo R, Xu M, Spitz DR, Wright WD, Roti Roti JL. Cytometric methods to analyze thermal effects Methods in Cell Biology. 269-286. PMID 11070844  1
2000 Wei SJ, Botero A, Hirota K, Bradbury CM, Markovina S, Laszlo A, Spitz DR, Goswami PC, Yodoi J, Gius D. Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation Cancer Research. 60: 6688-6695. PMID 11118054  1
2000 La Regina MC, Culbreth VO, Higashikubo R, Roti Roti JL, Spitz DR. An alternative method to stereotactic inoculation of transplantable brain tumours in large numbers of rats Laboratory Animals. 34: 265-271. PMID 11037120  1
2000 Goswami PC, Sheren J, Albee LD, Parsian A, Sim JE, Ridnour LA, Higashikubo R, Gius D, Hunt CR, Spitz DR. Cell cycle-coupled variation in topoisomerase IIα mRNA is regulated by the 3′-untranslated region: Possible role of redox-sensitive protein binding in mRNA accumulation Journal of Biological Chemistry. 275: 38384-38392. PMID 10986283 DOI: 10.1074/jbc.M005298200  1
2000 Hollensworth SB, Shen C, Sim JE, Spitz DR, Wilson GL, LeDoux SP. Glial cell type-specific responses to menadione-induced oxidative stress. Free Radical Biology & Medicine. 28: 1161-74. PMID 10889445 DOI: 10.1016/S0891-5849(00)00214-8  1
2000 Ercal N, Neal R, Treeratphan P, Lutz PM, Hammond TC, Dennery PA, Spitz DR. A role for oxidative stress in suppressing serum immunoglobulin levels in lead-exposed Fisher 344 rats. Archives of Environmental Contamination and Toxicology. 39: 251-6. PMID 10871428 DOI: 10.1007/s002440010102  1
2000 Ridnour LA, Sim JE, Hayward MA, Wink DA, Martin SM, Buettner GR, Spitz DR. A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media. Analytical Biochemistry. 281: 223-9. PMID 10870839 DOI: 10.1006/abio.2000.4583  1
2000 Spitz DR, Sim JE, Ridnour LA, Galoforo SS, Lee YJ. Glucose deprivation-induced oxidative stress in human tumor cells. A fundamental defect in metabolism? Annals of the New York Academy of Sciences. 899: 349-362. PMID 10863552  1
2000 Lee YJ, Galoforo SS, Sim JE, Ridnour LA, Choi J, Forman HJ, Corry PM, Spitz DR. Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line Free Radical Biology and Medicine. 28: 575-584. PMID 10719239 DOI: 10.1016/S0891-5849(99)00267-1  1
1999 Higashikubo R, Culbreth VO, Spitz DR, LaRegina MC, Pickard WF, Straube WL, Moros EG, Roti Roti JL. Radiofrequency electromagnetic fields have no effect on the in vivo proliferation of the 9L brain tumor Radiation Research. 152: 665-671. PMID 10581537  1
1999 Diamond DA, Parsian A, Hunt CR, Lofgren S, Spitz DR, Goswami PC, Gius D. Redox factor-1 (Ref-1) mediates the activation of AP-1 in HeLa and NIH 3T3 cells in response to heat shock. The Journal of Biological Chemistry. 274: 16959-64. PMID 10358044 DOI: 10.1074/jbc.274.24.16959  1
1999 Ridnour LA, Winters RA, Ercal N, Spitz DR. Measurement of glutathione, glutathione disulfide, and other thiols in mammalian cell and tissue homogenates using high-performance liquid chromatography separation of N-(1-pyrenyl)maleimide derivatives. Methods in Enzymology. 299: 258-67. PMID 9916204 DOI: 10.1016/S0076-6879(99)99025-0  1
1999 Blackburn RV, Spitz DR, Liu X, Galoforo SS, Sim JE, Ridnour LA, Chen JC, Davis BH, Corry PM, Lee YJ. Metabolic oxidative stress activates signal transduction and gene expression during glucose deprivation in human tumor cells Free Radical Biology and Medicine. 26: 419-430. PMID 9895234 DOI: 10.1016/S0891-5849(98)00217-2  1
1998 Gurer H, Ozgunes H, Neal R, Spitz DR, Ercal N. Antioxidant effects of N-acetylcysteine and succimer in red blood cells from lead-exposed rats Toxicology. 128: 181-189. PMID 9750041 DOI: 10.1016/S0300-483X(98)00074-2  1
1998 Hunt CR, Sim JE, Sullivan SJ, Featherstone T, Golden W, Von Kapp-Herr C, Hock RA, Gomez RA, Parsian AJ, Spitz DR. Genomic instability and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Research. 58: 3986-92. PMID 9731512  1
1998 Polavarapu R, Spitz DR, Sim JE, Follansbee MH, Oberley LW, Rahemtulla A, Nanji AA. Increased lipid peroxidation and impaired antioxidant enzyme function is associated with pathological liver injury in experimental alcoholic liver disease in rats fed diets high in corn oil and fish oil Hepatology. 27: 1317-1323. PMID 9581686 DOI: 10.1002/hep.510270518  1
1998 Bojes HK, Suresh PK, Mills EM, Spitz DR, Sim JE, Kehrer JP. Bcl-2 and Bcl-x(L) in peroxide-resistant A549 and U87MG cells Toxicological Sciences. 42: 109-116. PMID 9579023 DOI: 10.1006/toxs.1997.2416  1
1998 Brown KE, Kinter MT, Oberley TD, Freeman ML, Frierson HF, Ridnour LA, Tao Y, Oberley LW, Spitz DR. Enhanced γ-glutamyl transpeptidase expression and selective loss of CuZn superoxide dismutase in hepatic iron overload Free Radical Biology and Medicine. 24: 545-555. PMID 9559866 DOI: 10.1016/S0891-5849(97)00284-0  1
1998 Dennery PA, Spitz DR, Yang G, Tatarov A, Lee CS, Shegog ML, Poss KD. Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2. The Journal of Clinical Investigation. 101: 1001-11. PMID 9486970 DOI: 10.1172/JCI448  1
1998 Lee YJ, Galoforo SS, Berns CM, Chen JC, Davis BH, Sim JE, Corry PM, Spitz DR. Glucose deprivation-induced cytotoxicity and alterations in mitogen- activated protein kinase activation are mediated by oxidative stress in multidrug-resistant human breast carcinoma cells Journal of Biological Chemistry. 273: 5294-5299. PMID 9478987 DOI: 10.1074/jbc.273.9.5294  1
1997 Goswami PC, Albee LD, Spitz DR, Ridnour LA. A polymerase chain reaction assay for simultaneous detection and quantitation of proto-oncogene and GAPD mRNAs in different cell growth rates Cell Proliferation. 30: 271-282. PMID 9451418  1
1997 Sekhar KR, Meredith MJ, Kerr LD, Soltaninassab SR, Spitz DR, Xu ZQ, Freeman ML. Expression of glutathione and gamma-glutamylcysteine synthetase mRNA is Jun dependent. Biochemical and Biophysical Research Communications. 234: 588-93. PMID 9175757 DOI: 10.1006/bbrc.1997.6697  1
1997 Dennery PA, Sridhar KJ, Lee CS, Wong HE, Shokoohi V, Rodgers PA, Spitz DR. Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts. The Journal of Biological Chemistry. 272: 14937-42. PMID 9169465 DOI: 10.1074/jbc.272.23.14937  1
1996 Kinter M, Spitz DR, Roberts RJ. Oleic acid incorporation protects cultured hamster fibroblasts from oxygen-induced cytotoxicity Journal of Nutrition. 126: 2952-2959. PMID 9001361  1
1996 Ercal N, Oztezcan S, Hammond TC, Matthews RH, Spitz DR. High-performance liquid chromatography assay for N-acetylcysteine in biological samples following derivatization with N-(1-pyrenyl)maleimide Journal of Chromatography B: Biomedical Applications. 685: 329-334. PMID 8953175 DOI: 10.1016/S0378-4347(96)00196-X  1
1996 Dennery PA, Wong HE, Sridhar KJ, Rodgers PA, Sim JE, Spitz DR. Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts. The American Journal of Physiology. 271: L672-9. PMID 8897916  1
1996 Ercal N, Treeratphan P, Hammond TC, Matthews RH, Grannemann NH, Spitz DR. In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-dimercaptosuccinic acid or N- acetylcysteine Free Radical Biology and Medicine. 21: 157-161. PMID 8818630 DOI: 10.1016/0891-5849(96)00020-2  1
1996 Guyton KZ, Spitz DR, Holbrook NJ. Expression of stress response genes GADD153, c-jun, and heme oxygenase-1 in H2O2- and O2-resistant fibroblasts Free Radical Biology and Medicine. 20: 735-741. PMID 8721617 DOI: 10.1016/0891-5849(95)02151-5  1
1996 Huot J, Houle F, Spitz DR, Landry J. HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Research. 56: 273-9. PMID 8542580  1
1995 Whit Walker M, Kinter MT, Roberts RJ, Spitz DR. Nitric oxide-induced cytotoxicity: Involvement of cellular resistance to oxidative stress and the role of glutathione in protection Pediatric Research. 37: 41-49. PMID 7700733  1
1995 Winters RA, Zukowski J, Ercal N, Matthews RH, Spitz DR. Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide. Analytical Biochemistry. 227: 14-21. PMID 7668373 DOI: 10.1006/abio.1995.1246  1
1995 Spitz DR, Kinter MT, Roberts RJ. Contribution of increased glutathione content to mechanisms of oxidative stress resistance in hydrogen peroxide resistant hamster fibroblasts Journal of Cellular Physiology. 165: 600-609. PMID 7593239 DOI: 10.1002/jcp.1041650318  1
1995 Dennery PA, McDonagh AF, Spitz DR, Rodgers PA, Stevenson DK. Hyperbilirubinemia results in reduced oxidative injury in neonatal Gunn rats exposed to hyperoxia. Free Radical Biology & Medicine. 19: 395-404. PMID 7590389 DOI: 10.1016/0891-5849(95)00032-S  1
1993 Goligorsky MS, Morgan MA, Lyubsky S, Gross RW, Adams DT, Spitz DR. Establishment of a Hydrogen Peroxide Resistant Variant of Renal Tubular Epithelial Cells: Role of Calcium-Independent Phospholipase A2 in Cell Damage Archives of Biochemistry and Biophysics. 301: 119-128. PMID 8442655 DOI: 10.1006/abbi.1993.1123  1
1993 Spitz DR, Phillips JW, Adams DT, Sherman CM, Deen DF, Li GC. Cellular resistance to oxidative stress is accompanied by resistance to cisplatin: The significance of increased catalase activity and total glutathione in hydrogen peroxide‐resistant fibroblasts Journal of Cellular Physiology. 156: 72-79. PMID 8314861 DOI: 10.1002/jcp.1041560111  1
1992 Spitz DR, Adams DT, Sherman CM, Roberts RJ. Mechanisms of cellular resistance to hydrogen peroxide, hyperoxia, and 4-hydroxy-2-nonenal toxicity: The significance of increased catalase activity in H2O2-resistant fibroblasts Archives of Biochemistry and Biophysics. 292: 221-227. PMID 1727639 DOI: 10.1016/0003-9861(92)90071-4  1
1992 Park YM, Anderson RL, Spitz DR, Hahn GM. Hypoxia and resistance to hydrogen peroxide confer resistance to tumor necrosis factor in murine L929 cells. Radiation Research. 131: 162-8. PMID 1641471  1
1992 Sullivan SJ, Oberley TD, Roberts RJ, Spitz DR. A stable O2-resistant cell line: Role of lipid peroxidation byproducts in O2-mediated injury American Journal of Physiology - Lung Cellular and Molecular Physiology. 262. PMID 1616058  1
1992 Spitz DR, Kinter MT, Kehrer JP, Roberts RJ. The effect of monosaturated and polyunsaturated fatty acids on oxygen toxicity in cultured cells Pediatric Research. 32: 366-372. PMID 1408477  1
1991 Sullivan SJ, Roberts RJ, Spitz DR. Replacement of media in cell culture alters oxygen toxicity: Possible role of lipid aldehydes and glutathione transferases in oxygen toxicity Journal of Cellular Physiology. 147: 427-433. PMID 2066363 DOI: 10.1002/jcp.1041470307  1
1991 Spitz DR, Sullivan SJ, Malcolm RR, Roberts RJ. Glutathione dependent metabolism and detoxification of 4-hydroxy-2-nonenal Free Radical Biology and Medicine. 11: 415-423. PMID 1797627 DOI: 10.1016/0891-5849(91)90159-Z  1
1990 Peak MJ, Jones CA, Sedita BA, Dudek EJ, Spitz DR, Peak JG. Evidence that hydrogen peroxide generated by 365-nm UVA radiation is not important in mammalian cell killing. Radiation Research. 123: 220-3. PMID 2389008 DOI: 10.2307/3577548  1
1990 Spitz DR, Elwell JH, Sun Y, Oberley LW, Oberley TD, Sullivan SJ, Roberts RJ. Oxygen toxicity in control and H2O2-resistant Chinese hamster fibroblast cell lines Archives of Biochemistry and Biophysics. 279: 249-260. PMID 2350176 DOI: 10.1016/0003-9861(90)90489-L  1
1990 Spitz DR, Malcolm RR, Roberts RJ. Cytotoxicity and metabolism of 4-hydroxy-2-nonenal and 2-nonenal in H2O2-resistant cell lines: do aldehydic by-products of lipid peroxidation contribute to oxidative stress? Biochemical Journal. 267: 453-459. PMID 2334404  1
1990 Spitz DR, Li GC. Heat‐induced cytotoxicity in H2O2‐resistant Chinese hamster fibroblasts Journal of Cellular Physiology. 142: 255-260. PMID 2303525 DOI: 10.1002/jcp.1041420206  1
1990 Freeman ML, Spitz DR, Meredith MJ. Does heat shock enhance oxidative stress? Studies with ferrous and ferric iron. Radiation Research. 124: 288-93. PMID 2175921 DOI: 10.2307/3577841  1
1989 Spitz DR, Mackey MA, Li GC, Elwell JH, McCormick ML, Oberley LW. Relationship between changes in ploidy and stable cellular resistance to hydrogen peroxide. Journal of Cellular Physiology. 139: 592-8. PMID 2738104 DOI: 10.1002/jcp.1041390320  1
1989 Spitz DR, Oberley LW. An assay for superoxide dismutase activity in mammalian tissue homogenates Analytical Biochemistry. 179: 8-18. PMID 2547324 DOI: 10.1016/0003-2697(89)90192-9  1
1988 Spitz DR, Li GC, McCormick ML, Sun Y, Oberley LW. Stable H2O2-resistant variants of Chinese hamster fibroblasts demonstrate increases in catalase activity. Radiation Research. 114: 114-24. PMID 3353499  1
1988 Spitz DR, Li GC, McCormick ML, Sun Y, Oberley LW. The isolation and partial characterization of stable H2O2-resistant variants of Chinese hamster fibroblasts. Basic Life Sciences. 49: 549-52. PMID 3250510  1
1984 Oberley LW, Spitz DR. Assay of superoxide dismutase activity in tumor tissue Methods in Enzymology. 457-464. PMID 6547201  1
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