William E. Van Nostrand - Publications

Affiliations: 
Stony Brook University, Stony Brook, NY, United States 
Area:
Neuroscience Biology, Biochemistry, Cell Biology

120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Xu F, Van Nostrand WE. Data on thrombotic ischemic lesions in the presence or absence of amyloid ß-protein precursor or its homolog amyloid precursor-like protein-2 in mice. Data in Brief. 6: 149-52. PMID 26858980 DOI: 10.1016/j.dib.2015.11.050  1
2016 Van Nostrand WE. The influence of the amyloid ß-protein and its precursor in modulating cerebral hemostasis. Biochimica Et Biophysica Acta. 1862: 1018-26. PMID 26519139 DOI: 10.1016/j.bbadis.2015.10.020  1
2015 Fu Z, Aucoin D, Davis J, Van Nostrand WE, Smith SO. Mechanism of Nucleated Conformational Conversion of Aβ42. Biochemistry. 54: 4197-207. PMID 26069943 DOI: 10.1021/acs.biochem.5b00467  1
2015 Ou-Yang MH, Xu F, Liao MC, Davis J, Robinson JK, Van Nostrand WE. The N-terminal region of myelin basic protein reduces fibrillar amyloid-β deposition in Tg-5xFAD mice. Neurobiology of Aging. 36: 801-11. PMID 25457550 DOI: 10.1016/j.neurobiolaging.2014.10.006  1
2014 Fu Z, Aucoin D, Ahmed M, Ziliox M, Van Nostrand WE, Smith SO. Capping of aβ42 oligomers by small molecule inhibitors. Biochemistry. 53: 7893-903. PMID 25422864 DOI: 10.1021/bi500910b  1
2014 Xu F, Kotarba AE, Ou-Yang MH, Fu Z, Davis J, Smith SO, Van Nostrand WE. Early-onset formation of parenchymal plaque amyloid abrogates cerebral microvascular amyloid accumulation in transgenic mice. The Journal of Biological Chemistry. 289: 17895-908. PMID 24828504 DOI: 10.1074/jbc.M113.536565  1
2014 Park L, Koizumi K, El Jamal S, Zhou P, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. Age-dependent neurovascular dysfunction and damage in a mouse model of cerebral amyloid angiopathy. Stroke; a Journal of Cerebral Circulation. 45: 1815-21. PMID 24781082 DOI: 10.1161/STROKEAHA.114.005179  1
2014 Xu W, Xu F, Anderson ME, Kotarba AE, Davis J, Robinson JK, Van Nostrand WE. Cerebral microvascular rather than parenchymal amyloid-β protein pathology promotes early cognitive impairment in transgenic mice. Journal of Alzheimer's Disease : Jad. 38: 621-32. PMID 24037035 DOI: 10.3233/JAD-130758  1
2013 Ou-Yang MH, Van Nostrand WE. The absence of myelin basic protein promotes neuroinflammation and reduces amyloid β-protein accumulation in Tg-5xFAD mice. Journal of Neuroinflammation. 10: 134. PMID 24188129 DOI: 10.1186/1742-2094-10-134  1
2013 Hu ZI, Kotarba AM, Van Nostrand WE. Absence of Nitric Oxide Synthase 3 Increases Amyloid β-Protein Pathology in Tg-5xFAD Mice. Neuroscience and Medicine. 4: 84-91. PMID 24159423 DOI: 10.4236/nm.2013.42013  1
2013 Kotarba AE, Aucoin D, Hoos MD, Smith SO, Van Nostrand WE. Fine mapping of the amyloid β-protein binding site on myelin basic protein. Biochemistry. 52: 2565-73. PMID 23510371 DOI: 10.1021/bi4001936  1
2013 Park L, Zhou P, Koizumi K, El Jamal S, Previti ML, Van Nostrand WE, Carlson G, Iadecola C. Brain and circulating levels of Aβ1-40 differentially contribute to vasomotor dysfunction in the mouse brain. Stroke; a Journal of Cerebral Circulation. 44: 198-204. PMID 23204056 DOI: 10.1161/STROKEAHA.112.670976  1
2012 Xu F, Vitek MP, Colton CA, Previti ML, Davis J, Van Nostrand WE. Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice. Journal of Alzheimer's Disease : Jad. 31: 359-69. PMID 22635103 DOI: 10.3233/JAD-2012-120421  1
2012 Ladiwala AR, Litt J, Kane RS, Aucoin DS, Smith SO, Ranjan S, Davis J, Van Nostrand WE, Tessier PM. Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity. The Journal of Biological Chemistry. 287: 24765-73. PMID 22547072 DOI: 10.1074/jbc.M111.329763  1
2012 Vitek MP, Christensen DJ, Wilcock D, Davis J, Van Nostrand WE, Li FQ, Colton CA. APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. Neuro-Degenerative Diseases. 10: 122-6. PMID 22326991 DOI: 10.1159/000334914  1
2012 Van Nostrand WE, Davis J, Previti ML, Xu F. Clearance of amyloid-β protein deposits in transgenic mice following focal cerebral ischemia Neurodegenerative Diseases. 10: 108-111. PMID 22269180 DOI: 10.1159/000334763  1
2011 Blackshear AL, Xu W, Anderson M, Xu F, Previti ML, Van Nostrand WE, Robinson JK. A novel operant testing regimen for multi-construct cognitive characterization of a murine model of Alzheimer's amyloid-related behavioral impairment. Neurobiology of Learning and Memory. 96: 443-51. PMID 21763776 DOI: 10.1016/j.nlm.2011.06.017  1
2011 Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-beta. Proceedings of the National Academy of Sciences of the United States of America. 108: 5063-8. PMID 21383152 DOI: 10.1073/pnas.1015413108  1
2010 Robert R, Lefranc MP, Ghochikyan A, Agadjanyan MG, Cribbs DH, Van Nostrand WE, Wark KL, Dolezal O. Restricted V gene usage and VH/VL pairing of mouse humoral response against the N-terminal immunodominant epitope of the amyloid β peptide. Molecular Immunology. 48: 59-72. PMID 20970857 DOI: 10.1016/j.molimm.2010.09.012  1
2010 Van Nostrand WE, Xu F, Rozemuller AJ, Colton CA. Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. Stroke; a Journal of Cerebral Circulation. 41: S135-8. PMID 20876489 DOI: 10.1161/STROKEAHA.110.595272  1
2010 Liao MC, Hoos MD, Aucoin D, Ahmed M, Davis J, Smith SO, Van Nostrand WE. N-terminal domain of myelin basic protein inhibits amyloid beta-protein fibril assembly. The Journal of Biological Chemistry. 285: 35590-8. PMID 20807757 DOI: 10.1074/jbc.M110.169599  1
2010 Ahmed M, Davis J, Aucoin D, Sato T, Ahuja S, Aimoto S, Elliott JI, Van Nostrand WE, Smith SO. Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nature Structural & Molecular Biology. 17: 561-7. PMID 20383142 DOI: 10.1038/nsmb.1799  1
2010 Liao MC, Van Nostrand WE. Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro. Biochemistry. 49: 1127-36. PMID 20050683 DOI: 10.1021/bi901994d  1
2010 Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA. Amyloid reduction by amyloid-β vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease (The Journal of Neuroscience (2009) (7957-7965)) Journal of Neuroscience. 30: 1197-1198.  1
2009 Liao MC, Ahmed M, Smith SO, Van Nostrand WE. Degradation of amyloid beta protein by purified myelin basic protein. The Journal of Biological Chemistry. 284: 28917-25. PMID 19692707 DOI: 10.1074/jbc.M109.050856  1
2009 Wilcock DM, Gharkholonarehe N, Van Nostrand WE, Davis J, Vitek MP, Colton CA. Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7957-65. PMID 19553436 DOI: 10.1523/JNEUROSCI.1339-09.2009  1
2009 Xu F, Previti ML, Nieman MT, Davis J, Schmaier AH, Van Nostrand WE. AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5666-70. PMID 19403832 DOI: 10.1523/JNEUROSCI.0095-09.2009  1
2009 Hoos MD, Ahmed M, Smith SO, Van Nostrand WE. Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro. Biochemistry. 48: 4720-7. PMID 19385666 DOI: 10.1021/bi900037s  1
2008 Colton CA, Wilcock DM, Wink DA, Davis J, Van Nostrand WE, Vitek MP. The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. Journal of Alzheimer's Disease : Jad. 15: 571-87. PMID 19096157  1
2008 Van Vickle GD, Esh CL, Daugs ID, Kokjohn TA, Kalback WM, Patton RL, Luehrs DC, Walker DG, Lue LF, Beach TG, Davis J, Van Nostrand WE, Castaño EM, Roher AE. Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy. The American Journal of Pathology. 173: 483-93. PMID 18599612 DOI: 10.2353/ajpath.2008.071191  1
2008 Xu F, Vitek MP, Colton CA, Previti ML, Gharkholonarehe N, Davis J, Van Nostrand WE. Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5312-20. PMID 18480287 DOI: 10.1523/JNEUROSCI.1042-08.2008  1
2008 Wilcock DM, Lewis MR, Van Nostrand WE, Davis J, Previti ML, Gharkholonarehe N, Vitek MP, Colton CA. Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1537-45. PMID 18272675 DOI: 10.1523/JNEUROSCI.5066-07.2008  1
2007 Vasilevko V, Xu F, Previti ML, Van Nostrand WE, Cribbs DH. Experimental investigation of antibody-mediated clearance mechanisms of amyloid-beta in CNS of Tg-SwDI transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13376-83. PMID 18057195 DOI: 10.1523/JNEUROSCI.2788-07.2007  1
2007 Fan R, DeFilippis K, Van Nostrand WE. Induction of complement proteins in a mouse model for cerebral microvascular A beta deposition. Journal of Neuroinflammation. 4: 22. PMID 17877807 DOI: 10.1186/1742-2094-4-22  1
2007 Xu F, Previti ML, Van Nostrand WE. Increased severity of hemorrhage in transgenic mice expressing cerebral protease nexin-2/amyloid beta-protein precursor. Stroke; a Journal of Cerebral Circulation. 38: 2598-601. PMID 17656662 DOI: 10.1161/STROKEAHA.106.480103  1
2007 Fan R, Xu F, Previti ML, Davis J, Grande AM, Robinson JK, Van Nostrand WE. Minocycline reduces microglial activation and improves behavioral deficits in a transgenic model of cerebral microvascular amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3057-63. PMID 17376966 DOI: 10.1523/JNEUROSCI.4371-06.2007  1
2007 Xu F, Grande AM, Robinson JK, Previti ML, Vasek M, Davis J, Van Nostrand WE. Early-onset subicular microvascular amyloid and neuroinflammation correlate with behavioral deficits in vasculotropic mutant amyloid β-protein precursor transgenic mice Neuroscience. 146: 98-107. PMID 17331655 DOI: 10.1016/j.neuroscience.2007.01.043  1
2007 Hoos MD, Ahmed M, Smith SO, Van Nostrand WE. Inhibition of familial cerebral amyloid angiopathy mutant amyloid beta-protein fibril assembly by myelin basic protein. The Journal of Biological Chemistry. 282: 9952-61. PMID 17259179 DOI: 10.1074/jbc.M603494200  1
2006 Yamamoto N, Van Nostrand WE, Yanagisawa K. Further evidence of local ganglioside-dependent amyloid beta-protein assembly in brain. Neuroreport. 17: 1735-7. PMID 17047463 DOI: 10.1097/01.wnr.0000239958.53072.14  1
2006 Carrasco J, Adlard P, Cotman C, Quintana A, Penkowa M, Xu F, Van Nostrand WE, Hidalgo J. Metallothionein-I and -III expression in animal models of Alzheimer disease. Neuroscience. 143: 911-22. PMID 17027170 DOI: 10.1016/j.neuroscience.2006.08.054  1
2006 Colton CA, Mott RT, Sharpe H, Xu Q, Van Nostrand WE, Vitek MP. Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD. Journal of Neuroinflammation. 3: 27. PMID 17005052 DOI: 10.1186/1742-2094-3-27  1
2006 Colton CA, Vitek MP, Wink DA, Xu Q, Cantillana V, Previti ML, Van Nostrand WE, Weinberg JB, Weinberg B, Dawson H. NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 103: 12867-72. PMID 16908860 DOI: 10.1073/pnas.0601075103  1
2006 Previti ML, Zhang W, Van Nostrand WE. Dexamethasone diminishes the pro-inflammatory and cytotoxic effects of amyloid beta-protein in cerebrovascular smooth muscle cells. Journal of Neuroinflammation. 3: 18. PMID 16887032 DOI: 10.1186/1742-2094-3-18  1
2006 Herzig MC, Van Nostrand WE, Jucker M. Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models. Brain Pathology (Zurich, Switzerland). 16: 40-54. PMID 16612981 DOI: 10.1111/j.1750-3639.2006.tb00560.x  1
2006 Davis J, Xu F, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE. Deficient cerebral clearance of vasculotropic mutant Dutch/Iowa Double A beta in human A betaPP transgenic mice. Neurobiology of Aging. 27: 946-54. PMID 16105708 DOI: 10.1016/j.neurobiolaging.2005.05.031  1
2005 Xu F, Davis J, Miao J, Previti ML, Romanov G, Ziegler K, Van Nostrand WE. Protease nexin-2/amyloid beta-protein precursor limits cerebral thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 18135-40. PMID 16330760 DOI: 10.1073/pnas.0507798102  1
2005 Miao J, Xu F, Davis J, Otte-Höller I, Verbeek MM, Van Nostrand WE. Cerebral microvascular amyloid beta protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid beta precursor protein. The American Journal of Pathology. 167: 505-15. PMID 16049335  0.36
2005 Miao J, Vitek MP, Xu F, Previti ML, Davis J, Van Nostrand WE. Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 6271-7. PMID 16000616 DOI: 10.1523/JNEUROSCI.1306-05.2005  1
2005 Wilhelmus MM, Otte-Höller I, Davis J, Van Nostrand WE, de Waal RM, Verbeek MM. Apolipoprotein E genotype regulates amyloid-beta cytotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3621-7. PMID 15814793 DOI: 10.1523/JNEUROSCI.4213-04.2005  1
2005 Yamamoto N, Hirabayashi Y, Amari M, Yamaguchi H, Romanov G, Van Nostrand WE, Yanagisawa K. Assembly of hereditary amyloid beta-protein variants in the presence of favorable gangliosides. Febs Letters. 579: 2185-90. PMID 15811339 DOI: 10.1016/j.febslet.2005.03.013  1
2005 Miao J, Xu F, Davis J, Otte-Höller I, Verbeek MM, Van Nostrand WE. Cerebral microvascular amyloid β protein deposition induces vascular degeneration and neuroinflammation in transgenic mice expressing human vasculotropic mutant amyloid β precursor protein American Journal of Pathology. 167: 505-515.  1
2004 Deane R, Wu Z, Sagare A, Davis J, Du Yan S, Hamm K, Xu F, Parisi M, LaRue B, Hu HW, Spijkers P, Guo H, Song X, Lenting PJ, Van Nostrand WE, et al. LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms. Neuron. 43: 333-44. PMID 15294142 DOI: 10.1016/j.neuron.2004.07.017  1
2004 Davis J, Xu F, Deane R, Romanov G, Previti ML, Zeigler K, Zlokovic BV, Van Nostrand WE. Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor. The Journal of Biological Chemistry. 279: 20296-306. PMID 14985348 DOI: 10.1074/jbc.M312946200  1
2003 Davis J, Wagner MR, Zhang W, Xu F, Van Nostrand WE. Amyloid beta-protein stimulates the expression of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in human cerebrovascular smooth muscle cells. The Journal of Biological Chemistry. 278: 19054-61. PMID 12754271 DOI: 10.1074/jbc.M301398200  1
2003 Jung SS, Zhang W, Van Nostrand WE. Pathogenic A beta induces the expression and activation of matrix metalloproteinase-2 in human cerebrovascular smooth muscle cells. Journal of Neurochemistry. 85: 1208-15. PMID 12753080 DOI: 10.1046/j.1471-4159.2003.01745.x  1
2003 Jung SS, Van Nostrand WE. Humanin rescues human cerebrovascular smooth muscle cells from Abeta-induced toxicity. Journal of Neurochemistry. 84: 266-72. PMID 12558989 DOI: 10.1046/j.1471-4159.2003.01524.x  1
2002 Van Nostrand WE, Melchor JP, Romanov G, Zeigler K, Davis J. Pathogenic effects of cerebral amyloid angiopathy mutations in the amyloid beta-protein precursor. Annals of the New York Academy of Sciences. 977: 258-65. PMID 12480759  1
2002 Jung SS, Van Nostrand WE. Abeta does not induce oxidative stress in human cerebrovascular smooth muscle cells. Neuroreport. 13: 1309-12. PMID 12151793  1
2002 Van Nostrand WE, Melchor JP, Keane DM, Saporito-Irwin SM, Romanov G, Davis J, Xu F. Localization of a fibrillar amyloid beta-protein binding domain on its precursor. The Journal of Biological Chemistry. 277: 36392-8. PMID 12107175 DOI: 10.1074/jbc.M204676200  1
2001 Van Nostrand WE, Melchor JP. Disruption of pathologic amyloid beta-protein fibril assembly on the surface of cultured human cerebrovascular smooth muscle cells. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 8: 20-7. PMID 11676286  1
2001 Van Nostrand WE, Melchor JP, Cho HS, Greenberg SM, Rebeck GW. Pathogenic Effects of D23N Iowa Mutant Amyloid β-Protein Journal of Biological Chemistry. 276: 32860-32866. PMID 11441013 DOI: 10.1074/jbc.M104135200  1
2000 Van Nostrand WE. Cellular and transgenic animal models of cerebrovascular amyloidosis Molecular Medicine Today. 6: 373-374. PMID 10954871 DOI: 10.1016/S1357-4310(00)01762-7  1
2000 Mahdi F, Rehemtulla A, Van Nostrand WE, Bajaj SP, Schmaier AH. Protease nexin-2/amyloid β-protein precursor regulates factor VIIa and the factor VIIa-tissue factor complex Thrombosis Research. 99: 267-276. PMID 10942793 DOI: 10.1016/S0049-3848(00)00245-0  1
2000 Wagner MR, Keane DM, Melchor JP, Auspaker KR, Van Nostrand WE. Fibrillar amyloid beta-protein binds protease nexin-2/amyloid beta-protein precursor: stimulation of its inhibition of coagulation factor XIa. Biochemistry. 39: 7420-7. PMID 10858290 DOI: 10.1021/bi0002840  1
2000 Verbeek MM, Van Nostrand WE, Otte-Höller I, Wesseling P, De Waal RMW. Amyloid-β-induced degeneration of human brain pericytes is dependent on the apolipoprotein E genotype Annals of the New York Academy of Sciences. 903: 187-199. PMID 10818507  1
2000 Van Nostrand WE, Melchor J, Wagner M, Davis J. Cerebrovascular smooth muscle cell surface fibrillar aβ Annals of the New York Academy of Sciences. 903: 89-96. PMID 10818493  1
2000 Melchor JP, McVoy L, Van Nostrand WE. Charge alterations of E22 enhance the pathogenic properties of the amyloid beta-protein. Journal of Neurochemistry. 74: 2209-12. PMID 10800967 DOI: 10.1046/j.1471-4159.2000.0742209.x  1
2000 Melchor JP, Van Nostrand WE. Fibrillar amyloid beta-protein mediates the pathologic accumulation of its secreted precursor in human cerebrovascular smooth muscle cells. The Journal of Biological Chemistry. 275: 9782-91. PMID 10734132 DOI: 10.1074/jbc.275.13.9782  1
1999 Davis J, Cribbs DH, Cotman CW, Van Nostrand WE. Pathogenic amyloid beta-protein induces apoptosis in cultured human cerebrovascular smooth muscle cells. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 6: 157-64. PMID 10524279  1
1999 Van Nostrand WE, Porter M. Plasmin cleavage of the amyloid β-protein: Alteration of secondary structure and stimulation of tissue plasminogen activator activity Biochemistry. 38: 11570-11576. PMID 10471309 DOI: 10.1021/bi990610f  1
1998 Bornebroek M, Von Dem Borne PAK, Haan J, Meijers JCM, Van Nostrand WE, Roos RAC. Binding of amyloid β precursor protein to coagulation factor XIa in vivo may favour haemorrhagic stroke Journal of Neurology. 245: 111-115. PMID 9507418 DOI: 10.1007/s004150050188  1
1998 Van Nostrand WE, Melchor JP, Ruffini L. Pathologic amyloid beta-protein cell surface fibril assembly on cultured human cerebrovascular smooth muscle cells. Journal of Neurochemistry. 70: 216-23. PMID 9422365  1
1997 Zhang Y, Scandura JM, Van Nostrand WE, Walsh PN. The mechanism by which heparin promotes the inhibition of coagulation factor XIa by protease nexin-2. The Journal of Biological Chemistry. 272: 26139-44. PMID 9334179 DOI: 10.1074/jbc.272.42.26139  1
1997 Verbeek MM, De Waal RMW, Schipper JJ, Van Nostrand WE. Rapid degeneration of cultured human brain pericytes by amyloid β protein Journal of Neurochemistry. 68: 1135-1141. PMID 9048759  1
1997 Scandura JM, Zhang Y, Van Nostrand WE, Walsh PN. Progress curve analysis of the kinetics with which blood coagulation factor XIa is inhibited by protease nexin-2. Biochemistry. 36: 412-20. PMID 9003194 DOI: 10.1021/bi9612576  1
1997 Verbeek MM, De Waal RMW, Van Nostrand WE. Aβ-induced cytotoxicity: A model for cerebral vascular degeneration in Alzheimer's disease Endothelium: Journal of Endothelial Cell Research. 5: 355.  1
1997 Saporito-Irwin SM, Thinakaran G, Ruffini L, Sisodia SS, Van Nostrand WE. Amyloid ß-protein stimulates parallel increases in cellular levels of its precursor and amyloid precursor-like protein 2 (APLP2) in human cerebrovascular smooth muscle cells Amyloid. 4: 54-60.  1
1996 Van Nostrand WE, Davis-Salinas J, Saporito-Irwin SM. Amyloid β-protein induces the cerebrovascular cellular pathology of Alzheimer's disease and related disorders Annals of the New York Academy of Sciences. 777: 297-302. PMID 8624102  1
1996 Davis J, Van Nostrand WE. Enhanced pathologic properties of Dutch-type mutant amyloid β-protein Proceedings of the National Academy of Sciences of the United States of America. 93: 2996-3000. PMID 8610157 DOI: 10.1073/pnas.93.7.2996  1
1995 Verbeek MM, Otte-Höller I, Wesseling P, Van Nostrand WE, Sorg C, de Waal RMW, Ruiter DJ. A lysosomal marker for activated microglial cells involved in Alzheimer classic senile plaques Acta Neuropathologica. 90: 493-503. PMID 8560983 DOI: 10.1007/BF00294811  1
1995 Choi BH, Kim RC, Vaughan PJ, Lau A, Van Nostrand WE, Cotman CW, Cunningham DD. Decreases in protease nexins in Alzheimer's disease brain. Neurobiology of Aging. 16: 557-62. PMID 8544905 DOI: 10.1016/0197-4580(95)00060-R  1
1995 Van Nostrand WE. Zinc (II) selectively enhances the inhibition of coagulation factor XIa by protease nexin-2/amyloid β-Protein precursor Thrombosis Research. 78: 43-53. PMID 7778065 DOI: 10.1016/0049-3848(95)00033-X  1
1995 Davis-Salinas J, Van Nostrand WE. Amyloid β-protein aggregation nullifies its pathologic properties in cultured cerebrovascular smooth muscle cells Journal of Biological Chemistry. 270: 20887-20890. PMID 7673109 DOI: 10.1074/jbc.270.36.20887  1
1995 Veerhuis R, van der Valk P, Janssen I, Zhan SS, Eikelenboom P, Van Nostrand WE. Complement activation in amyloid plaques in Alzheimer's disease brains does not proceed further than C3 Virchows Archiv. 426: 603-610. PMID 7655742 DOI: 10.1007/BF00192116  1
1995 Gregori L, Fuchs C, Figueiredo-Pereira ME, Van Nostrand WE, Goldgaber D. Amyloid β-protein inhibits ubiquitin-dependent protein degradation in vitro Journal of Biological Chemistry. 270: 19702-19708. PMID 7649980 DOI: 10.1074/jbc.270.34.19702  1
1995 Davis-Salinas J, Saporito-Irwin SM, Cotman CW, Van Nostrand WE. Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. Journal of Neurochemistry. 65: 931-4. PMID 7616257  1
1995 Zhan SS, Kamphorst W, Van Nostrand WE, Eikelenboom P. Distribution of neuronal growth-promoting factors and cytoskeletal proteins in altered neurites in Alzheimer's disease and non-demented elderly Acta Neuropathologica. 89: 356-362. PMID 7610767 DOI: 10.1007/BF00309629  1
1995 Saporito-Irwin SM, Van Nostrand WE. Coagulation factor XIa cleaves the RHDS sequence and abolishes the cell adhesive properties of the amyloid β-protein Journal of Biological Chemistry. 270: 26265-26269. PMID 7592834 DOI: 10.1074/jbc.270.44.26265  1
1995 Mahdi F, Van Nostrand WE, Schmaier AH. Protease nexin-2/amyloid β-protein precursor inhibits factor Xa in the prothrombinase complex Journal of Biological Chemistry. 270: 23468-23474. PMID 7559509 DOI: 10.1074/jbc.270.40.23468  1
1995 Van Nostrand WE, Schmaier AH, Siegel RS, Wagner SL, Raschke WC. Enhanced plasmin inhibition by a reactive center lysine mutant of the Kunitz-type protease inhibitor domain of the amyloid β-protein precursor Journal of Biological Chemistry. 270: 22827-22830. PMID 7559414 DOI: 10.1074/jbc.270.39.22827  1
1994 Davis-Salinas J, Saporito-Irwin SM, Donovan FM, Cunningham DD, Van Nostrand WE. Thrombin receptor activation induces secretion and nonamyloidogenic processing of amyloid beta-protein precursor. The Journal of Biological Chemistry. 269: 22623-7. PMID 8077213  1
1994 Van Nostrand WE, Schmaier AH, Neiditch BR, Siegel RS, Raschke WC, Sisodia SS, Wagner SL. Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2. Biochimica Et Biophysica Acta. 1209: 165-70. PMID 7811686 DOI: 10.1016/0167-4838(94)90180-5  1
1994 Van Nostrand WE, Rozemuller AJM, Chung R, Cotman CW, Saporito-Irwin SM. Amyloid βprotein precursor in cultured leptomeningeal smooth muscle cells Amyloid. 1: 1-7. DOI: 10.3109/13506129409148618  1
1993 Wagner SL, Van Nostrand WE, Lau AL, Farrow JS, Suzuki M, Bartus RT, Schuppek R, Nguyen A, Cotman CW, Cunningham DD. Co-distribution of protease nexin-1 and protease nexin-2 in brains of non-human primates. Brain Research. 626: 90-8. PMID 8281456 DOI: 10.1016/0006-8993(93)90567-7  1
1993 Kibbey MC, Jucker M, Weeks BS, Neve RL, Van Nostrand WE, Kleinman HK. β-Amyloid precursor protein binds to the neurite-promoting IKVAV site of laminin Proceedings of the National Academy of Sciences of the United States of America. 90: 10150-10153. PMID 8234269 DOI: 10.1073/pnas.90.21.10150  1
1993 Schmaier AH, Dahl LD, Rozemuller AJM, Roos RAC, Wagner SL, Chung R, Van Nostrand WE. Protease nexin-2/amyloid β protein precursor. A tight-binding inhibitor of coagulation factor IXa Journal of Clinical Investigation. 92: 2540-2545. PMID 8227367  1
1993 Rozemuller AJM, Roos RAC, Bots GTAM, Kamphorst W, Eikelenboom P, Van Nostrand WE. Distribution of β/A4 protein and amyloid precursor protein in hereditary cerebral hemorrhage with amyloidosis-Dutch type and Alzheimer's disease American Journal of Pathology. 142: 1449-1457. PMID 7684195  1
1992 van Nostrand WE, Wagner SL, Haan J, Bakker E, Roos RAC. Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis–dutch type share a decrease in cerebrospinal fluid levels of amyloid β‐protein precursor Annals of Neurology. 32: 215-218. PMID 1510361 DOI: 10.1002/ana.410320214  1
1992 Wagner SL, Siegel RS, Vedvick TS, Raschke WC, Van Nostrand WE. High level expression, purification, and characterization of the Kunitz-type protease inhibitor domain of protease nexin-2/amyloid β-protein precursor Biochemical and Biophysical Research Communications. 186: 1138-1145. PMID 1497647 DOI: 10.1016/0006-291X(92)90865-I  1
1992 Cummings BJ, Su JH, Geddes JW, Van Nostrand WE, Wagner SL, Cunningham DD, Cotman CW. Aggregation of the amyloid precursor protein within degenerating neurons and dystrophic neurites in Alzheimer's disease. Neuroscience. 48: 763-77. PMID 1378573 DOI: 10.1016/0306-4522(92)90265-4  1
1992 Farlow M, Ghetti B, Benson MD, Farrow JS, van Nostrand WE, Wagner SL. Low cerebrospinal-fluid concentrations of soluble amyloid beta-protein precursor in hereditary Alzheimer's disease. Lancet. 340: 453-4. PMID 1354785 DOI: 10.1016/0140-6736(92)91771-Y  1
1992 VAN NOSTRAND WE, SCHMAIER AH, WAGNER SL. Potential Role of Protease Nexin‐2/Amyloid β‐Protein Precursor as a Cerebral Anticoagulant Annals of the New York Academy of Sciences. 674: 243-252. PMID 1288367 DOI: 10.1111/j.1749-6632.1992.tb27493.x  1
1991 Abraham CR, Driscoll J, Potter H, Van Nostrand WE, Tempst P. A calcium-activated protease from Alzheimer's disease brain cleaves at the N-terminus of the amyloid beta-protein. Biochemical and Biophysical Research Communications. 174: 790-6. PMID 1993072 DOI: 10.1016/0006-291X(91)91487-W  1
1991 Bhasin R, Van Nostrand WE, Saitoh T, Donets MA, Barnes EA, Quitschke WW, Goldgaber D. Expression of active secreted forms of human amyloid beta-protein precursor by recombinant baculovirus-infected insect cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 10307-11. PMID 1946449  1
1991 Van Nostrand WE, Farrow JS, Wagner SL, Bhasin R, Goldgaber D, Cotman CW, Cunningham DD. The predominant form of the amyloid beta-protein precursor in human brain is protease nexin 2. Proceedings of the National Academy of Sciences of the United States of America. 88: 10302-6. PMID 1946448  1
1991 Van Nostrand WE, Schmaier AH, Farrow JS, Cines DB, Cunningham DD. Protease nexin-2/amyloid beta-protein precursor in blood is a platelet-specific protein. Biochemical and Biophysical Research Communications. 175: 15-21. PMID 1900151 DOI: 10.1016/S0006-291X(05)81193-3  1
1991 Abraham CR, Razzaboni BL, Sisodia SS, Koo EH, Price DL, Van Nostrand WE, Papastoitsis G. Studies on the proteolytic degradation of the beta-protein precursor by proteases purified from Alzheimer's disease brain. Annals of the New York Academy of Sciences. 640: 161-5. PMID 1776735  1
1991 Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD. Platelet protease nexin-2/amyloid beta-protein precursor. Possible pathologic and physiologic functions. Annals of the New York Academy of Sciences. 640: 140-4. PMID 1776731  1
1991 Gajdusek DC, Beyreuther K, Brown P, Cork LC, Cunningham DD, Frangione B, Gibbs CJ, Goldfarb LG, Goldgaber D, Hsiao KK. Regulation and genetic control of brain amyloid. FESN Study Group. Brain Research. Brain Research Reviews. 16: 83-114. PMID 1677826 DOI: 10.1016/0165-0173(91)90021-Y  1
1990 Van Nostrand WE, Wagner SL, Farrow JS, Cunningham DD. Immunopurification and protease inhibitory properties of protease nexin-2/amyloid beta-protein precursor. The Journal of Biological Chemistry. 265: 9591-4. PMID 2112543  1
1990 Van Nostrand WE, Schmaier AH, Farrow JS, Cunningham DD. Protease nexin-II (amyloid beta-protein precursor): a platelet alpha-granule protein. Science (New York, N.Y.). 248: 745-8. PMID 2110384  1
1989 Van Nostrand WE, Wagner SL, Suzuki M, Choi BH, Farrow JS, Geddes JW, Cotman CW, Cunningham DD. Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursor. Nature. 341: 546-9. PMID 2507928 DOI: 10.1038/341546a0  1
1988 Van Nostrand WE, Wagner SL, Cunningham DD. Purification of a form of protease nexin 1 that binds heparin with a low affinity. Biochemistry. 27: 2176-81. PMID 3378053  1
1988 Wagner SL, Van Nostrand WE, Lau AL, Cunningham DD. Monoclonal antibodies to protease nexin 1 that differentially block its inhibition of target proteases. Biochemistry. 27: 2173-6. PMID 3378052  1
1988 Van Nostrand WE, McKay LD, Baker JB, Cunningham DD. Functional and structural similarities between protease nexin I and C1 inhibitor. The Journal of Biological Chemistry. 263: 3979-83. PMID 3279027  1
1987 Van Nostrand WE, Cunningham DD. Purification of a proteinase inhibitor from bovine serum with C1-inhibitor activity. Biochimica Et Biophysica Acta. 923: 167-75. PMID 3814612 DOI: 10.1016/0304-4165(87)90001-8  1
1987 Van Nostrand WE, Cunningham DD. Purification of protease nexin II from human fibroblasts. The Journal of Biological Chemistry. 262: 8508-14. PMID 3597385  1
1986 Cunningham DD, Van Nostrand WE, Farrell DH, Campbell CH. Interactions of serine proteases with cultured fibroblasts. Journal of Cellular Biochemistry. 32: 281-91. PMID 3543029 DOI: 10.1002/jcb.240320405  1
1986 Farrell DH, Van Nostrand WE, Cunningham DD. A simple two-step purification of protease nexin. The Biochemical Journal. 237: 907-12. PMID 3099760  1
1985 Van Nostrand WE, Cunningham DD. Purification of a protease nexin II-like inhibitor from bovine serum Federation Proceedings. 44.  1
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