Jeffrey Varner - Publications

Cornell University, Ithaca, NY, United States 
Chemical Engineering, Biomedical Engineering, Biochemistry, Systematic Biology

46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Bunaciu RP, MacDonald RJ, Jensen HA, Gao F, Wang X, Johnson L, Varner JD, Yen A. Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML. Leukemia & Lymphoma. 1-12. PMID 30570341 DOI: 10.1080/10428194.2018.1543880  0.4
2018 MacDonald RJ, Bunaciu RP, Ip V, Dai D, Tran D, Varner JD, Yen A. Src family kinase inhibitor bosutinib enhances retinoic acid-induced differentiation of HL-60 leukemia cells. Leukemia & Lymphoma. 1-11. PMID 29569971 DOI: 10.1080/10428194.2018.1452213  0.4
2018 Bunaciu RP, MacDonald RJ, Gao F, Johnson LM, Varner JD, Wang X, Nataraj S, Guzman ML, Yen A. Potential for subsets of wt-NPM1 primary AML blasts to respond to retinoic acid treatment. Oncotarget. 9: 4134-4149. PMID 29423110 DOI: 10.18632/oncotarget.23642  0.4
2017 Tasseff R, Jensen HA, Congleton J, Dai D, Rogers KV, Sagar A, Bunaciu RP, Yen A, Varner JD. An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program. Scientific Reports. 7: 14327. PMID 29085021 DOI: 10.1038/s41598-017-14523-5  0.52
2016 Gould R, Bassen DM, Chakrabarti A, Varner JD, Butcher J. Population Heterogeneity in the Epithelial to Mesenchymal Transition Is Controlled by NFAT and Phosphorylated Sp1. Plos Computational Biology. 12: e1005251. PMID 28027307 DOI: 10.1371/journal.pcbi.1005251  0.68
2015 Jensen HA, Yourish HB, Bunaciu RP, Varner JD, Yen A. Induced myelomonocytic differentiation in leukemia cells is accompanied by noncanonical transcription factor expression. Febs Open Bio. 5: 789-800. PMID 26566473 DOI: 10.1016/j.fob.2015.09.008  1
2015 Bunaciu RP, Jensen HA, MacDonald RJ, LaTocha DH, Varner JD, Yen A. 6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells. Plos One. 10: e0135668. PMID 26287494 DOI: 10.1371/journal.pone.0135668  1
2015 Hu CY, Varner J, Lucks JB. Generating effective models and parameters for RNA genetic circuits. Acs Synthetic Biology. PMID 26046393 DOI: 10.1021/acssynbio.5b00077  1
2015 Jensen HA, Bunaciu RP, Varner JD, Yen A. GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation. Cellular Signalling. 27: 1666-75. PMID 25817574 DOI: 10.1016/j.cellsig.2015.03.014  1
2014 Jensen HA, Bunaciu RP, Ibabao CN, Myers R, Varner JD, Yen A. Retinoic acid therapy resistance progresses from unilineage to bilineage in HL-60 leukemic blasts. Plos One. 9: e98929. PMID 24922062 DOI: 10.1371/journal.pone.0098929  1
2014 Portnoff AD, Stephens EA, Varner JD, DeLisa MP. Ubiquibodies, synthetic E3 ubiquitin ligases endowed with unnatural substrate specificity for targeted protein silencing. The Journal of Biological Chemistry. 289: 7844-55. PMID 24474696 DOI: 10.1074/jbc.M113.544825  1
2013 Verbridge SS, Chakrabarti A, DelNero P, Kwee B, Varner JD, Stroock AD, Fischbach C. Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model. Journal of Biomedical Materials Research. Part A. 101: 2948-56. PMID 23559519 DOI: 10.1002/jbm.a.34587  1
2013 Jensen HA, Styskal LE, Tasseff R, Bunaciu RP, Congleton J, Varner JD, Yen A. The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells. Plos One. 8: e58621. PMID 23554907 DOI: 10.1371/journal.pone.0058621  1
2013 Gould RA, Aboulmouna LM, Varner JD, Butcher JT. Hierarchical approaches for systems modeling in cardiac development. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 5: 289-305. PMID 23463736 DOI: 10.1002/wsbm.1217  1
2013 Wayman JA, Varner JD. Biological systems modeling of metabolic and signaling networks Current Opinion in Chemical Engineering. 2: 365-372. DOI: 10.1016/j.coche.2013.09.001  1
2013 Gould RA, Chakrabarti A, Butcher J, Varner J. Phenotypic heterogeneity in the epithelial to mesenchymal transition (EMT) is controlled by the NFAT and phosphorylated-Sp1 transcription factors Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 924.  1
2013 Wayman JA, Mansell TJ, DeLisa MP, Varner JD. Improving glycosylation yield in escherichia coli using an adapted genome-scale metabolic model and metaheuristic optimization techniques Food, Pharmaceutical and Bioengineering Division 2013 - Core Programming Area At the 2013 Aiche Annual Meeting: Global Challenges For Engineering a Sustainable Future. 690.  1
2012 Chakrabarti A, Verbridge S, Stroock AD, Fischbach C, Varner JD. Multiscale models of breast cancer progression. Annals of Biomedical Engineering. 40: 2488-500. PMID 23008097 DOI: 10.1007/s10439-012-0655-8  1
2012 Sun S, Titushkin I, Varner J, Cho M. Millimeter wave-induced modulation of calcium dynamics in an engineered skin co-culture model: role of secreted ATP on calcium spiking. Journal of Radiation Research. 53: 159-67. PMID 22510588 DOI: JST.JSTAGE/jrr/11037  1
2011 Lequieu J, Chakrabarti A, Nayak S, Varner JD. Computational modeling and analysis of insulin induced eukaryotic translation initiation. Plos Computational Biology. 7: e1002263. PMID 22102801 DOI: 10.1371/journal.pcbi.1002263  1
2011 Chakrabarti A, Chen AW, Varner JD. A review of the mammalian unfolded protein response. Biotechnology and Bioengineering. 108: 2777-93. PMID 21809331 DOI: 10.1002/bit.23282  1
2011 Shen M, Bunaciu RP, Congleton J, Jensen HA, Sayam LG, Varner JD, Yen A. Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells. Leukemia & Lymphoma. 52: 2372-9. PMID 21740303 DOI: 10.3109/10428194.2011.603449  1
2011 Tasseff R, Nayak S, Song SO, Yen A, Varner JD. Modeling and analysis of retinoic acid induced differentiation of uncommitted precursor cells. Integrative Biology : Quantitative Biosciences From Nano to Macro. 3: 578-91. PMID 21437295 DOI: 10.1039/c0ib00141d  1
2011 Nayak S, Siddiqui JK, Varner JD. Modelling and analysis of an ensemble of eukaryotic translation initiation models. Iet Systems Biology. 5: 2. PMID 21261397 DOI: 10.1049/iet-syb.2009.0065  1
2010 Luan D, Szlam F, Tanaka KA, Barie PS, Varner JD. Ensembles of uncertain mathematical models can identify network response to therapeutic interventions. Molecular Biosystems. 6: 2272-86. PMID 20844798 DOI: 10.1039/b920693k  1
2010 Reiterer G, Chen L, Tassef R, Varner JD, Chen CY, Yen A. RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition. Cell Cycle (Georgetown, Tex.). 9: 3297-304. PMID 20703093 DOI: 0.4161/cc.9.16.12631  1
2010 Song SO, Chakrabarti A, Varner JD. Ensembles of signal transduction models using Pareto Optimal Ensemble Techniques (POETs). Biotechnology Journal. 5: 768-80. PMID 20665647 DOI: 10.1002/biot.201000059  1
2010 Nayak S, Shen M, Bunaciu RP, Bloom SE, Varner JD, Yen A. Arsenic trioxide cooperates with all trans retinoic acid to enhance mitogen-activated protein kinase activation and differentiation in PML-RARalpha negative human myeloblastic leukemia cells. Leukemia & Lymphoma. 51: 1734-47. PMID 20615082 DOI: 10.3109/10428194.2010.501535  1
2010 Tasseff R, Nayak S, Salim S, Kaushik P, Rizvi N, Varner JD. Analysis of the molecular networks in androgen dependent and independent prostate cancer revealed fragile and robust subsystems. Plos One. 5: e8864. PMID 20126616 DOI: 10.1371/journal.pone.0008864  1
2010 Szlam F, Luan D, Bolliger D, Szlam AD, Levy JH, Varner JD, Tanaka KA. Anti-factor IXa Aptamer reduces propagation of thrombin generation in plasma anticoagulated with warfarin. Thrombosis Research. 125: 432-7. PMID 20004955 DOI: 10.1016/j.thromres.2009.11.018  1
2009 Song SO, Varner J. Modeling and analysis of the molecular basis of pain in sensory neurons. Plos One. 4: e6758. PMID 19750220 DOI: 10.1371/journal.pone.0006758  1
2008 Jin IK, Varner JD, Ramkrishna D. A hybrid model of anaerobic E. coli GJT001: Combination of elementary flux modes and cybernetic variables Biotechnology Progress. 24: 993-1006. PMID 19194908 DOI: 10.1002/btpr.73  1
2008 Conrado RJ, Varner JD, DeLisa MP. Engineering the spatial organization of metabolic enzymes: mimicking nature's synergy. Current Opinion in Biotechnology. 19: 492-9. PMID 18725290 DOI: 10.1016/j.copbio.2008.07.006  1
2008 Nayak S, Salim S, Luan D, Zai M, Varner JD. A test of highly optimized tolerance reveals fragile cell-cycle mechanisms are molecular targets in clinical cancer trials. Plos One. 3: e2016. PMID 18431497 DOI: 10.1371/journal.pone.0002016  1
2008 Luan D, Zai M, Varner JD. Factor XI is a potential therapeutic target for thrombosis that maintains hemostasis Aiche Annual Meeting, Conference Proceedings 1
2008 Tasseff RA, Nayak S, Kudela D, Siddiqui JK, Yen A, Varner JD. Mathematical modeling and analysis of the role of the BLR1 protein and MAPK activation in the growth-arrest and differentiation program of a model adult stem-cell Aiche Annual Meeting, Conference Proceedings 1
2008 Tasseff RA, Nayak S, Kaushia P, Rizvi N, Salim S, Varner JD. Formulation and analysis of an ultrascale protein interaction network involved in the androgen response of prostate cancer epithelial cells Aiche Annual Meeting, Conference Proceedings 1
2007 Luan D, Zai M, Varner JD. Computationally derived points of fragility of a human cascade are consistent with current therapeutic strategies. Plos Computational Biology. 3: e142. PMID 17658944 DOI: 10.1371/journal.pcbi.0030142  1
2007 Conrado RJ, Mansell TJ, Varner JD, DeLisa MP. Stochastic reaction-diffusion simulation of enzyme compartmentalization reveals improved catalytic efficiency for a synthetic metabolic pathway. Metabolic Engineering. 9: 355-63. PMID 17601761 DOI: 10.1016/j.ymben.2007.05.002  1
2007 Srivastava R, Varner J. Emerging technologies: systems biology. Biotechnology Progress. 23: 24-7. PMID 17269665 DOI: 10.1021/bp060352v  1
2007 Tasseff R, Nayak S, Luan D, Mansell T, Song SO, Varner J. Identification of fragile mechanisms in the human complement cascade is sensitive to the choice of numerical method for the solution of the sensitivity equations Aiche Annual Meeting, Conference Proceedings 1
2005 Varner JD. Systems biology and the mathematical modelling of antibody-directed enzyme prodrug therapy (ADEPT) Iee Proceedings Systems Biology. 152: 291-302. PMID 16986273 DOI: 10.1049/ip-syb:20050047  1
2005 Leclerc CA, Varner JD. Sensitivity of cybernetic models to variability in microarray data Aiche Annual Meeting, Conference Proceedings. 11779.  1
2003 Gadkar KG, Doyle FJ, Crowley TJ, Varner JD. Cybernetic model predictive control of a continuous bioreactor with cell recycle. Biotechnology Progress. 19: 1487-97. PMID 14524710 DOI: 10.1021/bp025776d  1
1999 Varner J, Ramkrishna D. Metabolic engineering from a cybernetic perspective: aspartate family of amino acids. Metabolic Engineering. 1: 88-116. PMID 10935757 DOI: 10.1006/mben.1998.0104  1
1999 Varner J, Ramkrishna D. Mathematical models of metabolic pathways. Current Opinion in Biotechnology. 10: 146-50. PMID 10209144 DOI: 10.1016/S0958-1669(99)80025-1  1
Show low-probability matches.