| Year |
Citation |
Score |
| 2023 |
Huber AD, Poudel S, Wu J, Miller DJ, Lin W, Yang L, Bwayi MN, Rimmer MA, Gee RRF, Seetharaman J, Chai SC, Chen T. A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR. Nucleic Acids Research. PMID 38084912 DOI: 10.1093/nar/gkad1175 |
0.324 |
|
| 2022 |
Li Y, Lin W, Chai SC, Wu J, Annu K, Chen T. Design and Optimization of 1-1,2,3-Triazole-4-carboxamides as Novel, Potent, and Selective Inverse Agonists and Antagonists of PXR. Journal of Medicinal Chemistry. 65: 16829-16859. PMID 36480704 DOI: 10.1021/acs.jmedchem.2c01640 |
0.317 |
|
| 2021 |
Li Y, Lin W, Wright WC, Chai SC, Wu J, Chen T. Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70. Journal of Medicinal Chemistry. PMID 33497575 DOI: 10.1021/acs.jmedchem.0c02201 |
0.301 |
|
| 2020 |
Huber AD, Wright WC, Lin W, Majumder K, Low JA, Wu J, Buchman CD, Pintel DJ, Chen T. Mutation of a single amino acid of pregnane X receptor switches an antagonist to agonist by altering AF-2 helix positioning. Cellular and Molecular Life Sciences : Cmls. PMID 32232515 DOI: 10.1007/S00018-020-03505-Y |
0.349 |
|
| 2019 |
Lin W, Bwayi M, Wu J, Li Y, Chai SC, Huber AD, Chen T. CITCO Directly Binds to and Activates Human Pregnane X Receptor. Molecular Pharmacology. PMID 31882411 DOI: 10.1124/Mol.119.118513 |
0.381 |
|
| 2019 |
Chai SC, Lin W, Li Y, Chen T. Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor. Drug Discovery Today. PMID 30731240 DOI: 10.1016/J.Drudis.2019.01.021 |
0.394 |
|
| 2018 |
Ippagunta SK, Pollock JA, Sharma N, Lin W, Chen T, Tawaratsumida K, High AA, Min J, Chen Y, Guy RK, Redecke V, Katzenellenbogen JA, Häcker H. Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins. Science Signaling. 11. PMID 30108181 DOI: 10.1126/Scisignal.Aaq1077 |
0.359 |
|
| 2018 |
Chang Y, Woessner DW, Lin W, Chen T, Xu B, Fan Y, Tan H, Peng J, Kasper L, Churchman ML, Gerhard DS, Loh ML, Hunger SP, Seth A, Gascoigne K, et al. Abstract IA12: Modeling and targeting CREBBP mutations in relapsed acute lymphoblastic leukemia Cancer Research. 78. DOI: 10.1158/1538-7445.Pedca17-Ia12 |
0.314 |
|
| 2017 |
Roberts KG, Yang YL, Payne-Turner D, Lin W, Files JK, Dickerson K, Gu Z, Taunton J, Janke LJ, Chen T, Loh ML, Hunger SP, Mullighan CG. Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL. Blood Advances. 1: 1657-1671. PMID 29296813 DOI: 10.1182/Bloodadvances.2017011296 |
0.335 |
|
| 2017 |
Pitre A, Ge Y, Lin W, Wang Y, Fukuda Y, Temirov J, Phillips AH, Peters JL, Fan Y, Ma J, Nourse A, Sinha C, Lin H, Kriwacki R, Downing JR, et al. An unexpected protein interaction promotes drug resistance in leukemia. Nature Communications. 8: 1547. PMID 29146910 DOI: 10.1038/S41467-017-01678-Y |
0.332 |
|
| 2017 |
Lin W, Goktug AN, Wu J, Currier DG, Chen T. High-Throughput Screening Identifies 1,4,5-Substituted 1,2,3-Triazole Analogs as Potent and Specific Antagonists of Pregnane X Receptor. Assay and Drug Development Technologies. PMID 29112465 DOI: 10.1089/adt.2017.809 |
0.33 |
|
| 2017 |
Lin W, Wang YM, Chai SC, Lv L, Zheng J, Wu J, Zhang Q, Wang YD, Griffin PR, Chen T. SPA70 is a potent antagonist of human pregnane X receptor. Nature Communications. 8: 741. PMID 28963450 DOI: 10.1038/S41467-017-00780-5 |
0.399 |
|
| 2017 |
Genthe JR, Min J, Farmer DM, Shelat AA, Grenet JA, Lin W, Finkelstein DB, Vrijens K, Chen T, Guy RK, Clements WK, Roussel MF. Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway. Acs Chemical Biology. PMID 28787124 DOI: 10.1021/Acschembio.7B00527 |
0.348 |
|
| 2017 |
Yang J, Milasta S, Hu D, AlTahan A, Interiano R, Zhou J, Davidson J, Low J, Lin W, Bao J, Goh P, Nathwani A, Wang R, Wang Y, Ong SS, et al. Targeting histone demethylases in MYC-driven neuroblastomas with ciclopirox. Cancer Research. PMID 28684529 DOI: 10.1158/0008-5472.Can-16-0826 |
0.32 |
|
| 2017 |
Oladimeji PO, Lin W, Brewer CT, Chen T. Glucose-dependent regulation of pregnane X receptor is modulated by AMP-activated protein kinase. Scientific Reports. 7: 46751. PMID 28436464 DOI: 10.1038/Srep46751 |
0.385 |
|
| 2016 |
Cherian MT, Yang L, Chai SC, Lin W, Chen T. Identification and characterization of CINPA1 metabolites facilitates structure-activity studies of the constitutive androstane receptor. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 27519550 DOI: 10.1124/Dmd.116.071993 |
0.403 |
|
| 2016 |
Sprowl JA, Ong SS, Gibson AA, Hu S, Du G, Lin W, Li L, Bharill S, Ness RA, Stecula A, Offer SM, Diasio RB, Nies AT, Schwab M, Cavaletti G, et al. A phosphotyrosine switch regulates organic cation transporters. Nature Communications. 7: 10880. PMID 26979622 DOI: 10.1038/Ncomms10880 |
0.384 |
|
| 2016 |
Comeaux E, Lin W, Chen T, Freeman B, Mullighan CG. PI3K and MEK Inhibition in Hypodiploid Acute Lymphoblastic Leukemia Blood. 128: 1635-1635. DOI: 10.1182/Blood.V128.22.1635.1635 |
0.362 |
|
| 2015 |
Lin W, Yang L, Chai SC, Lu Y, Chen T. Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor. European Journal of Medicinal Chemistry. 108: 505-528. PMID 26717202 DOI: 10.1016/J.Ejmech.2015.12.018 |
0.427 |
|
| 2015 |
Wang YM, Chai SC, Lin W, Chai X, Elias A, Wu J, Ong SS, Pondugula SR, Beard JA, Schuetz EG, Zeng S, Xie W, Chen T. Serine 350 of Human Pregnane X Receptor Is Crucial for Its Heterodimerization with Retinoid X Receptor Alpha and Transactivation of Target Genes in Vitro and in Vivo. Biochemical Pharmacology. PMID 26119819 DOI: 10.1016/J.Bcp.2015.06.018 |
0.39 |
|
| 2015 |
Cherian MT, Lin W, Wu J, Chen T. CINPA1 is an inhibitor of constitutive androstane receptor that does not activate pregnane X receptor. Molecular Pharmacology. 87: 878-89. PMID 25762023 DOI: 10.1124/Mol.115.097782 |
0.472 |
|
| 2015 |
Leung WH, Vong QP, Lin W, Bouck D, Wendt S, Sullivan E, Li Y, Bari R, Chen T, Leung W. PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. Journal of Immunology (Baltimore, Md. : 1950). 194: 2930-41. PMID 25687758 DOI: 10.4049/Jimmunol.1400817 |
0.331 |
|
| 2015 |
Sharma LK, Leonardi R, Lin W, Boyd VA, Goktug A, Shelat AA, Chen T, Jackowski S, Rock CO. A high-throughput screen reveals new small-molecule activators and inhibitors of pantothenate kinases. Journal of Medicinal Chemistry. 58: 1563-8. PMID 25569308 DOI: 10.1021/Jm501585Q |
0.399 |
|
| 2015 |
Cherian MT, Takwi AA, Lin W, Chen T. Abstract C76: A novel small molecule inhibitor of constitutive androstane receptor (CAR) that resensitizes doxorubicin-resistant neuroblastoma cells Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-C76 |
0.439 |
|
| 2014 |
Lin W, Liu J, Jeffries C, Yang L, Lu Y, Lee RE, Chen T. Development of BODIPY FL vindoline as a novel and high-affinity pregnane X receptor fluorescent probe. Bioconjugate Chemistry. 25: 1664-77. PMID 25133934 DOI: 10.1021/Bc5002856 |
0.389 |
|
| 2014 |
Yu DD, Lin W, Forman BM, Chen T. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorganic & Medicinal Chemistry. 22: 2919-38. PMID 24775917 DOI: 10.1016/J.Bmc.2014.04.014 |
0.403 |
|
| 2014 |
Walters BJ, Lin W, Diao S, Brimble M, Iconaru LI, Dearman J, Goktug A, Chen T, Zuo J. High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor. Plos One. 9: e91173. PMID 24646893 DOI: 10.1371/Journal.Pone.0091173 |
0.348 |
|
| 2014 |
Sun S, Playa HC, Deokar HS, Lin W, Buolamwini JK. Abstract 4478: Biopharmaceutic studies of novel nucleoside transporter inhibitor prodrugs that can protect against nucleoside drug-induced mitochondrial toxicity Cancer Research. 74: 4478-4478. DOI: 10.1158/1538-7445.Am2014-4478 |
0.607 |
|
| 2013 |
Leung WH, Vong QP, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXRγ activation. The Journal of Experimental Medicine. 210: 2675-92. PMID 24190430 DOI: 10.1084/Jem.20122292 |
0.351 |
|
| 2013 |
McCoy F, Darbandi R, Lee HC, Bharatham K, Moldoveanu T, Grace CR, Dodd K, Lin W, Chen SI, Tangallapally RP, Kurokawa M, Lee RE, Shelat AA, Chen T, Green DR, et al. Metabolic activation of CaMKII by coenzyme A. Molecular Cell. 52: 325-39. PMID 24095281 DOI: 10.1016/j.molcel.2013.08.043 |
0.324 |
|
| 2013 |
Lin W, Chen T. A vinblastine fluorescent probe for pregnane X receptor in a time-resolved fluorescence resonance energy transfer assay. Analytical Biochemistry. 443: 252-60. PMID 24044991 DOI: 10.4172/2155-9872.S1.017 |
0.404 |
|
| 2013 |
Wang C, Lin W, Playa H, Sun S, Cameron K, Buolamwini JK. Dipyridamole analogs as pharmacological inhibitors of equilibrative nucleoside transporters. Identification of novel potent and selective inhibitors of the adenosine transporter function of human equilibrative nucleoside transporter 4 (hENT4). Biochemical Pharmacology. 86: 1531-40. PMID 24021350 DOI: 10.1016/J.Bcp.2013.08.063 |
0.632 |
|
| 2013 |
Wang YM, Lin W, Chai SC, Wu J, Ong SS, Schuetz EG, Chen T. Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1. Toxicology and Applied Pharmacology. 272: 96-107. PMID 23707768 DOI: 10.1016/J.Taap.2013.05.014 |
0.423 |
|
| 2013 |
Yu DD, Lin W, Chen T, Forman BM. Development of time resolved fluorescence resonance energy transfer-based assay for FXR antagonist discovery. Bioorganic & Medicinal Chemistry. 21: 4266-78. PMID 23688559 DOI: 10.1016/J.Bmc.2013.04.069 |
0.378 |
|
| 2013 |
Vrijens K, Lin W, Cui J, Farmer D, Low J, Pronier E, Zeng FY, Shelat AA, Guy K, Taylor MR, Chen T, Roussel MF. Identification of small molecule activators of BMP signaling. Plos One. 8: e59045. PMID 23527084 DOI: 10.1371/Journal.Pone.0059045 |
0.338 |
|
| 2012 |
Li G, Lin W, Araya JJ, Chen T, Timmermann BN, Guo GL. A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor. Toxicology and Applied Pharmacology. 258: 268-74. PMID 22178739 DOI: 10.1016/J.Taap.2011.11.006 |
0.374 |
|
| 2011 |
Zhao Y, Hammoudeh D, Lin W, Das S, Yun MK, Li Z, Griffith E, Chen T, White SW, Lee RE. Development of a pterin-based fluorescent probe for screening dihydropteroate synthase. Bioconjugate Chemistry. 22: 2110-7. PMID 21916405 DOI: 10.1021/Bc200346E |
0.366 |
|
| 2011 |
Lin W, Buolamwini JK. Design, synthesis, and evaluation of 2-diethanolamino-4,8-diheptamethyleneimino-2-(N-aminoethyl-N-ethanolamino)-6-(N,N-diethanolamino)pyrimido[5,4-d]pyrimidine-fluorescein conjugate (8MDP-fluor), as a novel equilibrative nucleoside transporter probe. Bioconjugate Chemistry. 22: 1221-7. PMID 21539390 DOI: 10.1021/Bc2000758 |
0.604 |
|
| 2011 |
Vrijens K, Lin W, Cui J, Shelat A, Taylor M, Guy KR, Chen T, Roussel MF. Abstract 4522: Identification of small molecule agonists/activators of BMP-2, 4, 7 signaling Cancer Research. 71: 4522-4522. DOI: 10.1158/1538-7445.Am2011-4522 |
0.366 |
|
| 2010 |
Leonardi R, Zhang YM, Yun MK, Zhou R, Zeng FY, Lin W, Cui J, Chen T, Rock CO, White SW, Jackowski S. Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain. Chemistry & Biology. 17: 892-902. PMID 20797618 DOI: 10.1016/J.Chembiol.2010.06.006 |
0.397 |
|
| 2010 |
Dong H, Lin W, Wu J, Chen T. Flavonoids activate pregnane x receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells. Bmc Biochemistry. 11: 23. PMID 20553580 DOI: 10.1186/1471-2091-11-23 |
0.384 |
|
| 2008 |
Lin W, Wu J, Dong H, Bouck D, Zeng FY, Chen T. Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells. The Journal of Biological Chemistry. 283: 30650-7. PMID 18784074 DOI: 10.1074/Jbc.M806132200 |
0.4 |
|
| 2007 |
Lin W, Buolamwini JK. Synthesis, flow cytometric evaluation, and identification of highly potent dipyridamole analogues as equilibrative nucleoside transporter 1 inhibitors. Journal of Medicinal Chemistry. 50: 3906-20. PMID 17636949 DOI: 10.1021/Jm070311L |
0.629 |
|
| 2002 |
Xu P, Lin W, Zou X. Synthesis of a Peptidomimetic HCMV Protease Inhibitor Library Synthesis. 2002: 1017-1026. DOI: 10.1055/S-2002-31948 |
0.323 |
|
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