Hardik J. Patel, Ph.D. - Publications

2009 St. John's University (New York), School of Pharmacy 
Pharmaceutical Chemistry, Organic Chemistry, Pharmacology

19 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Shrestha L, Bolaender A, Patel HJ, Taldone T. Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease. Current Topics in Medicinal Chemistry. PMID 27072696  0.96
2016 Shrestha L, Patel HJ, Chiosis G. Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease. Cell Chemical Biology. 23: 158-72. PMID 26933742 DOI: 10.1016/j.chembiol.2015.12.006  0.96
2015 Patel HJ, Patel PD, Ochiana SO, Yan P, Sun W, Patel MR, Shah SK, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. Journal of Medicinal Chemistry. 58: 3922-43. PMID 25901531 DOI: 10.1021/acs.jmedchem.5b00197  0.96
2014 Taldone T, Patel HJ, Bolaender A, Patel MR, Chiosis G. Protein chaperones: a composition of matter review (2008 - 2013). Expert Opinion On Therapeutic Patents. 24: 501-18. PMID 24742089 DOI: 10.1517/13543776.2014.887681  0.96
2014 Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1208-24. PMID 24548239 DOI: 10.1021/jm401552y  0.96
2014 Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1188-207. PMID 24548207 DOI: 10.1021/jm401551n  0.96
2014 Bhagwat N, Koppikar P, Keller M, Marubayashi S, Shank K, Rampal R, Qi J, Kleppe M, Patel HJ, Shah SK, Taldone T, Bradner JE, Chiosis G, Levine RL. Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms. Blood. 123: 2075-83. PMID 24470592 DOI: 10.1182/blood-2014-01-547760  0.96
2013 Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, et al. Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chemistry & Biology. 20: 1469-80. PMID 24239008 DOI: 10.1016/j.chembiol.2013.10.008  0.96
2013 Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nature Chemical Biology. 9: 677-84. PMID 23995768 DOI: 10.1038/nchembio.1335  0.96
2013 Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D, Chiosis G. Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. Journal of Medicinal Chemistry. 56: 6803-18. PMID 23965125 DOI: 10.1021/jm400619b  0.96
2013 Taldone T, Rodina A, Dagama Gomes EM, Riolo M, Patel HJ, Alonso-Sabadell R, Zatorska D, Patel MR, Kishinevsky S, Chiosis G. Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes. Beilstein Journal of Organic Chemistry. 9: 544-56. PMID 23616796 DOI: 10.3762/bjoc.9.60  0.96
2013 Taldone T, Zatorska D, Patel HJ, Sun W, Patel MR, Chiosis G. Preparation of a diverse purine-scaffold library via one-step palladium catalyzed cross-coupling Heterocycles. 87: 91-113. DOI: 10.3987/COM-12-12613  0.96
2012 Taldone T, Patel PD, Patel HJ, Chiosis G. About the reaction of aryl fluorides with sodium sulfide: Investigation into the selectivity of substitution of fluorobenzonitriles to yield mercaptobenzonitriles via S NAr displacement of fluorine Tetrahedron Letters. 53: 2548-2551. DOI: 10.1016/j.tetlet.2012.03.032  0.96
2011 Patel HJ, Modi S, Chiosis G, Taldone T. Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment. Expert Opinion On Drug Discovery. 6: 559-587. PMID 22400044 DOI: 10.1517/17460441.2011.563296  0.96
2010 Patel HJ, Olgun N, Lengyel I, Reznik S, Stephani RA. Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acids as selective ET(A) antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 6840-4. PMID 20932745 DOI: 10.1016/j.bmcl.2010.08.074  0.96
2010 Olgun NS, Patel HJ, Stephani R, Lengyel I, Reznik SE. Blockade of endothelin-1 with a novel series of 1,3,6-trisubstituted-2-carboxy-quinol-4-ones controls infection-associated preterm birth. The American Journal of Pathology. 177: 1929-35. PMID 20802183 DOI: 10.2353/ajpath.2010.100281  0.96
2008 Olgun N, Patel HJ, Stephani R, Wang W, Yen H, Reznik SE. Effect of the putative novel selective ETA-receptor antagonist HJP272, a 1,3,6-trisubstituted-2-carboxy-quinol-4-one, on infection-mediated premature delivery. Canadian Journal of Physiology and Pharmacology. 86: 571-5. PMID 18758506 DOI: 10.1139/Y08-057  0.96
2007 Lengyei I, Patel HJ, Stephani RA. The preparation and characterization of nineteen new phthalidyl spirohydantoins Heterocycles. 73: 349-375. DOI: 10.3987/COM-07-S(U)9  0.96
2006 Patel HJ, Sarra J, Caruso F, Rossi M, Doshi U, Stephani RA. Synthesis and anticonvulsant activity of new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones. Bioorganic & Medicinal Chemistry Letters. 16: 4644-7. PMID 16793262 DOI: 10.1016/j.bmcl.2006.05.102  0.96
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