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Carlo L. Condello, Ph.D. - Publications

Affiliations: 
Institute for Neurodegenerative Diseases University of California, San Francisco, San Francisco, CA 
Area:
Neurodegenerative diseases, Biology of Neuron-Glial interactions
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37 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Ghosh U, Tse E, Shi M, Yang H, Wang F, Merz GE, Prusiner SB, Southworth DR, Condello C. Cryo-EM Structures Reveal Tau Filaments from Down Syndrome Adopt Alzheimer's Disease Fold. Biorxiv : the Preprint Server For Biology. PMID 38617229 DOI: 10.1101/2024.04.02.587507  0.632
2023 Wallace HM, Yang H, Tan S, Pan HS, Yang R, Xu J, Jo H, Condello C, Polizzi NF, DeGrado WF. Design of Peptides that Bind Specific Conformers of α-Synuclein. Biorxiv : the Preprint Server For Biology. PMID 38014268 DOI: 10.1101/2023.11.14.567090  0.335
2023 Kandi S, Cline EN, Rivera BM, Viola KL, Zhu J, Condello C, LeDuc RD, Klein WL, Kelleher NL, Patrie SM. Amyloid β Proteoforms Elucidated by Quantitative LC/MS in the 5xFAD Mouse Model of Alzheimer's Disease. Journal of Proteome Research. 22: 3475-3488. PMID 37847596 DOI: 10.1021/acs.jproteome.3c00353  0.504
2023 Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Goodness D, Tian R, Grosjean P, Abskharon R, Eisenberg D, Kanaan NM, Gan L, Condello C, Swaney DL, Kampmann M. CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. Biorxiv : the Preprint Server For Biology. PMID 37398204 DOI: 10.1101/2023.06.16.545386  0.364
2023 Condello C, Ayers JI, Dalgard CL, Garcia Garcia MM, Rivera BM, Seeley WW, Perl DP, Prusiner SB. Guam ALS-PDC is a distinct double-prion disorder featuring both tau and Aβ prions. Proceedings of the National Academy of Sciences of the United States of America. 120: e2220984120. PMID 36952379 DOI: 10.1073/pnas.2220984120  0.598
2023 Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C. EMBER multidimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains. Proceedings of the National Academy of Sciences of the United States of America. 120: e2300769120. PMID 36927157 DOI: 10.1073/pnas.2300769120  0.56
2023 Yang H, Yuan P, Wu Y, Shi M, Caro CD, Tengeiji A, Yamanoi S, Inoue M, DeGrado WF, Condello C. EMBER multi-dimensional spectral microscopy enables quantitative determination of disease- and cell-specific amyloid strains. Biorxiv : the Preprint Server For Biology. PMID 36778268 DOI: 10.1101/2023.02.01.526692  0.546
2023 Johnson NR, Yuan P, Castillo E, Lopez TP, Yue W, Bond A, Rivera BM, Sullivan MC, Hirouchi M, Giles K, Aoyagi A, Condello C. CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model. Nature Communications. 14: 118. PMID 36624100 DOI: 10.1038/s41467-022-35753-w  0.41
2022 Condello C, Merz GE, Aoyagi A, DeGrado WF, Prusiner SB. Aβ and Tau Prions Causing Alzheimer's Disease. Methods in Molecular Biology (Clifton, N.J.). 2561: 293-337. PMID 36399277 DOI: 10.1007/978-1-0716-2655-9_16  0.658
2022 Condello C, Maxwell AM, Castillo E, Aoyagi A, Graff C, Ingelsson M, Lannfelt L, Bird TD, Keene CD, Seeley WW, Perl DP, Head E, Prusiner SB. Aβ and tau prions feature in the neuropathogenesis of Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 119: e2212954119. PMID 36343257 DOI: 10.1073/pnas.2212954119  0.621
2022 Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, et al. Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature Communications. 13: 1969. PMID 35413950 DOI: 10.1038/s41467-022-29552-6  0.321
2022 Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB. Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35115402 DOI: 10.1073/pnas.2113489119  0.694
2022 Belsare KD, Wu H, Mondal D, Bond A, Castillo E, Jin J, Jo H, Roush AE, Pilla KB, Sali A, Condello C, DeGrado WF. Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35082148 DOI: 10.1073/pnas.2114486119  0.48
2021 Maxwell AM, Yuan P, Rivera BM, Schaaf W, Mladinov M, Prasher VP, Robinson AC, DeGrado WF, Condello C. Emergence of distinct and heterogeneous strains of amyloid beta with advanced Alzheimer's disease pathology in Down syndrome. Acta Neuropathologica Communications. 9: 201. PMID 34961556 DOI: 10.1186/s40478-021-01298-0  0.536
2020 Condello C, DeGrado WF, Prusiner SB. Prion biology: implications for Alzheimer's disease therapeutics. The Lancet. Neurology. 19: 802-803. PMID 32949533 DOI: 10.1016/S1474-4422(20)30274-X  0.585
2019 Aoyagi A, Condello C, Stöhr J, Yue W, Rivera BM, Lee JC, Woerman AL, Halliday G, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Keene CD, Seeley WW, et al. Aβ and tau prion-like activities decline with longevity in the Alzheimer's disease human brain. Science Translational Medicine. 11. PMID 31043574 DOI: 10.1126/Scitranslmed.Aat8462  0.807
2019 Didonna A, Cantó E, Shams H, Isobe N, Zhao C, Caillier SJ, Condello C, Yamate-Morgan H, Tiwari-Woodruff SK, Mofrad MRK, Hauser SL, Oksenberg JR. Sex-specific Tau methylation patterns and synaptic transcriptional alterations are associated with neural vulnerability during chronic neuroinflammation. Journal of Autoimmunity. PMID 31010726 DOI: 10.1016/J.Jaut.2019.04.003  0.423
2018 Mok SA, Condello C, Freilich R, Gillies A, Arhar T, Oroz J, Kadavath H, Julien O, Assimon VA, Rauch JN, Dunyak BM, Lee J, Tsai FTF, Wilson MR, Zweckstetter M, et al. Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature Structural & Molecular Biology. 25: 384-393. PMID 29728653 DOI: 10.1038/S41594-018-0057-1  0.454
2018 Condello C, Lemmin T, Stöhr J, Nick M, Wu Y, Maxwell AM, Watts JC, Caro CD, Oehler A, Keene CD, Bird TD, van Duinen SG, Lannfelt L, Ingelsson M, Graff C, et al. Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 29311311 DOI: 10.1073/Pnas.1714966115  0.788
2017 Johnson NR, Condello C, Guan S, Oehler A, Becker J, Gavidia M, Carlson GA, Giles K, Prusiner SB. Evidence for sortilin modulating regional accumulation of human tau prions in transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29203673 DOI: 10.1073/Pnas.1717193114  0.641
2017 Condello C, Yuan P, Grutzendler J. Microglia-Mediated Neuroprotection, TREM2, and Alzheimer's Disease: Evidence From Optical Imaging. Biological Psychiatry. PMID 29169609 DOI: 10.1016/J.Biopsych.2017.10.007  0.784
2017 Lopez TP, Giles K, Dugger BN, Oehler A, Condello C, Krejciova Z, Castaneda JA, Carlson GA, Prusiner SB. A novel vector for transgenesis in the rat CNS. Acta Neuropathologica Communications. 5: 84. PMID 29157304 DOI: 10.1186/S40478-017-0484-Y  0.456
2017 Stöhr J, Wu H, Nick M, Wu Y, Bhate M, Condello C, Johnson N, Rodgers J, Lemmin T, Acharya S, Becker J, Robinson K, Kelly MJS, Gai F, Stubbs G, et al. A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells. Nature Chemistry. 9: 874-881. PMID 28837163 DOI: 10.1038/Nchem.2754  0.568
2017 Condello C, Stöehr J. Aβ propagation and strains: Implications for the phenotypic diversity in Alzheimer's disease. Neurobiology of Disease. 109: 191-200. PMID 28359847 DOI: 10.1016/J.Nbd.2017.03.014  0.571
2016 Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 92: 252-264. PMID 27710785 DOI: 10.1016/j.neuron.2016.09.016  0.696
2016 Giles K, Berry DB, Condello C, Dugger BN, Li Z, Oehler A, Bhardwaj S, Elepano M, Guan S, Silber BM, Olson SH, Prusiner SB. Optimization of aryl amides that extend survival in prion-infected mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 27317802 DOI: 10.1124/Jpet.116.235556  0.51
2016 Yuan P, Condello C, Keene CD, Wang Y, Bird TD, Paul SM, Luo W, Colonna M, Baddeley D, Grutzendler J. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. 90: 724-739. PMID 27196974 DOI: 10.1016/J.Neuron.2016.05.003  0.804
2015 Giles K, Berry DB, Condello C, Hawley RC, Gallardo-Godoy A, Bryant C, Oehler A, Elepano M, Bhardwaj S, Patel S, Silber BM, Guan S, DeArmond SJ, Renslo AR, Prusiner SB. Different 2-Aminothiazole Therapeutics Produce Distinct Patterns of Scrapie Prion Neuropathology in Mouse Brains. The Journal of Pharmacology and Experimental Therapeutics. 355: 2-12. PMID 26224882 DOI: 10.1124/Jpet.115.224659  0.567
2015 Giles K, Berry D, Condello C, Bhardwaj S, Oehler A, Gallardo-Godoy A, DeArmond S, Renslo A, Prusiner S. Improving therapeutic efficacy of 2-aminothiazoles in PrP prion disease Prion. 9. PMID 25970046 DOI: 10.1080/19336896.2015.1033248  0.472
2015 Condello C, Yuan P, Schain A, Grutzendler J. Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques. Nature Communications. 6: 6176. PMID 25630253 DOI: 10.1038/Ncomms7176  0.794
2014 Watts JC, Condello C, Stöhr J, Oehler A, Lee J, DeArmond SJ, Lannfelt L, Ingelsson M, Giles K, Prusiner SB. Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients. Proceedings of the National Academy of Sciences of the United States of America. 111: 10323-8. PMID 24982139 DOI: 10.1073/Pnas.1408900111  0.78
2014 Stöhr J, Condello C, Watts JC, Bloch L, Oehler A, Nick M, DeArmond SJ, Giles K, DeGrado WF, Prusiner SB. Distinct synthetic Aβ prion strains producing different amyloid deposits in bigenic mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 10329-34. PMID 24982137 DOI: 10.1073/Pnas.1408968111  0.751
2013 Condello C, Yuan P, Das P, Grutzendler J. P2-018: Microglia constitute a barrier that prevents the formation of neurotoxic oligomeric beta-amyloid hot spots around plaques Alzheimer's & Dementia. 9: P351-P351. DOI: 10.1016/J.Jalz.2013.05.660  0.733
2013 Yuan P, Condello C, Schain A, Grutzendler J. P1-033: A time stamp imaging method for measuring the kinetics and toxicity of beta-amyloid and tau deposition by sequential multicolor labeling with beta-sheet binding dyes Alzheimer's & Dementia. 9: P164-P164. DOI: 10.1016/J.Jalz.2013.05.253  0.744
2011 Condello C, Schain A, Grutzendler J. Multicolor time-stamp reveals the dynamics and toxicity of amyloid deposition. Scientific Reports. 1: 19. PMID 22355538 DOI: 10.1038/Srep00019  0.8
2010 Liu Z, Condello C, Schain A, Harb R, Grutzendler J. CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-β phagocytosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 17091-101. PMID 21159979 DOI: 10.1523/Jneurosci.4403-10.2010  0.779
2006 Condello C, Aoyagi A, Stöhr J, Lee JC, Rivera BM, Woerman AL, Halliday GM, van Duinen S, Ingelsson M, Lannfelt L, Graff C, Bird TD, Dirk Keene C, Seeley WW, DeGrado WF, et al. P4-233: AGED ALZHEIMER'S DISEASE BRAINS EXHIBIT NUMEROUS Aβ BUT ONLY FEW TAU PRIONS Alzheimer's & Dementia. 14: P1531-P1532. DOI: 10.1016/J.Jalz.2018.07.054  0.786
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