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Santosh D'Mello, Ph.D. - Publications

Affiliations: 
Molecular and Cell Biology University of Texas at Dallas, Richardson, TX, United States 
Area:
Neurodegenerative diseases, HDACs
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69 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 D'Mello SR. MECP2 and the Biology of MECP2 Duplication Syndrome. Journal of Neurochemistry. PMID 33638179 DOI: 10.1111/jnc.15331  0.317
2019 Pfister JA, Ma C, D'Mello SR. Catalytic-independent neuroprotection by SIRT1 is mediated through interaction with HDAC1. Plos One. 14: e0215208. PMID 30973934 DOI: 10.1371/journal.pone.0215208  0.723
2018 Qu Z, Titus ASCLS, Xuan Z, D'Mello SR. Neuroprotection by Heat Shock Factor-1 (HSF1) and Trimerization-Deficient Mutant Identifies Novel Alterations in Gene Expression. Scientific Reports. 8: 17255. PMID 30467350 DOI: 10.1038/S41598-018-35610-1  0.686
2018 Montgomery KR, Louis Sam Titus ASC, Wang L, D'Mello SR. Elevated MeCP2 in Mice Causes Neurodegeneration Involving Tau Dysregulation and Excitotoxicity: Implications for the Understanding and Treatment of MeCP2 Triplication Syndrome. Molecular Neurobiology. PMID 29637441 DOI: 10.1007/s12035-018-1046-4  0.321
2018 Qu Z, D'Mello SR. Proteomic analysis identifies NPTX1 and HIP1R as potential targets of histone deacetylase-3-mediated neurodegeneration. Experimental Biology and Medicine (Maywood, N.J.). 1535370218761149. PMID 29486577 DOI: 10.1177/1535370218761149  0.686
2017 Louis Sam Titus ASC, Yusuff T, Cassar M, Thomas E, Kretzschmar D, D'Mello SR. Reduced expression of Foxp1 as a contributing factor in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28550168 DOI: 10.1523/Jneurosci.3612-16.2017  0.455
2016 Pfister JA, D'Mello SR. Regulation of neuronal survival by nucleophosmin 1 (NPM1) is dependent on its expression level, subcellular localization and oligomerization status. The Journal of Biological Chemistry. PMID 27510036 DOI: 10.1074/jbc.M116.723015  0.772
2016 Rawat V, Goux W, Piechaczyk M, D'Mello SR. c-Fos Protects Neurons Through a Noncanonical Mechanism Involving HDAC3 Interaction: Identification of a 21-Amino Acid Fragment with Neuroprotective Activity. Molecular Neurobiology. 53: 1165-80. PMID 25592718 DOI: 10.1007/s12035-014-9058-1  0.807
2015 Smith C, D'Mello SR. Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival. Molecular Neurobiology. PMID 26476842 DOI: 10.1007/s12035-015-9452-3  0.54
2015 Pfister JA, D'Mello SR. Insights into the regulation of neuronal viability by nucleophosmin/B23. Experimental Biology and Medicine (Maywood, N.J.). 240: 774-86. PMID 25908633 DOI: 10.1177/1535370215579168  0.729
2015 Sharma D, Kim MS, D'Mello SR. Transcriptome profiling of expression changes during neuronal death by RNA-Seq. Experimental Biology and Medicine (Maywood, N.J.). 240: 242-51. PMID 25258427 DOI: 10.1177/1535370214551688  0.463
2014 Norwood J, Franklin JM, Sharma D, D'Mello SR. Histone deacetylase 3 is necessary for proper brain development. The Journal of Biological Chemistry. 289: 34569-82. PMID 25339172 DOI: 10.1074/jbc.M114.576397  0.83
2014 Mallick S, D'Mello SR. JAZ (Znf346), a SIRT1-interacting protein, protects neurons by stimulating p21 (WAF/CIP1) protein expression. The Journal of Biological Chemistry. 289: 35409-20. PMID 25331946 DOI: 10.1074/jbc.M114.597575  0.854
2014 Verma P, Pfister JA, Mallick S, D'Mello SR. HSF1 protects neurons through a novel trimerization- and HSP-independent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1599-612. PMID 24478344 DOI: 10.1523/Jneurosci.3039-13.2014  0.849
2013 Bardai FH, Verma P, Smith C, Rawat V, Wang L, D'Mello SR. Disassociation of histone deacetylase-3 from normal huntingtin underlies mutant huntingtin neurotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11833-8. PMID 23864673 DOI: 10.1523/Jneurosci.5831-12.2013  0.807
2013 Price V, Wang L, D'Mello SR. Conditional deletion of histone deacetylase-4 in the central nervous system has no major effect on brain architecture or neuronal viability. Journal of Neuroscience Research. 91: 407-15. PMID 23239283 DOI: 10.1002/jnr.23170  0.423
2012 Bardai FH, Price V, Zaayman M, Wang L, D'Mello SR. Histone deacetylase-1 (HDAC1) is a molecular switch between neuronal survival and death. The Journal of Biological Chemistry. 287: 35444-53. PMID 22918830 DOI: 10.1074/jbc.M112.394544  0.865
2012 Dastidar SG, Bardai FH, Ma C, Price V, Rawat V, Verma P, Narayanan V, D'Mello SR. Isoform-specific toxicity of Mecp2 in postmitotic neurons: suppression of neurotoxicity by FoxG1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 2846-55. PMID 22357867 DOI: 10.1523/Jneurosci.5841-11.2012  0.823
2012 Dastidar SG, Narayanan S, Stifani S, D'Mello SR. Transducin-like enhancer of Split-1 (TLE1) combines with Forkhead box protein G1 (FoxG1) to promote neuronal survival. The Journal of Biological Chemistry. 287: 14749-59. PMID 22354967 DOI: 10.1074/Jbc.M111.328336  0.573
2011 Bardai FH, D'Mello SR. Selective toxicity by HDAC3 in neurons: regulation by Akt and GSK3beta. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 1746-51. PMID 21289184 DOI: 10.1523/JNEUROSCI.5704-10.2011  0.873
2011 Dastidar SG, Landrieu PM, D'Mello SR. FoxG1 promotes the survival of postmitotic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 402-13. PMID 21228151 DOI: 10.1523/JNEUROSCI.2897-10.2011  0.533
2011 Ma C, D'Mello SR. Neuroprotection by histone deacetylase-7 (HDAC7) occurs by inhibition of c-jun expression through a deacetylase-independent mechanism. The Journal of Biological Chemistry. 286: 4819-28. PMID 21118817 DOI: 10.1074/jbc.M110.146860  0.567
2010 Chen HL, D'Mello SR. Induction of neuronal cell death by paraneoplastic Ma1 antigen. Journal of Neuroscience Research. 88: 3508-19. PMID 20936693 DOI: 10.1002/jnr.22506  0.72
2010 Wang L, Ankati H, Akubathini SK, Balderamos M, Storey CA, Patel AV, Price V, Kretzschmar D, Biehl ER, D'Mello SR. Identification of novel 1,4-benzoxazine compounds that are protective in tissue culture and in vivo models of neurodegeneration. Journal of Neuroscience Research. 88: 1970-84. PMID 20143421 DOI: 10.1002/Jnr.22352  0.473
2009 D'Mello SR. Histone deacetylases as targets for the treatment of human neurodegenerative diseases. Drug News & Perspectives. 22: 513-24. PMID 20072728 DOI: 10.1358/dnp.2009.9.1428871  0.462
2008 Pfister JA, Ma C, Morrison BE, D'Mello SR. Opposing effects of sirtuins on neuronal survival: SIRT1-mediated neuroprotection is independent of its deacetylase activity. Plos One. 3: e4090. PMID 19116652 DOI: 10.1371/journal.pone.0004090  0.85
2008 Chen HM, Wang L, D'Mello SR. A chemical compound commonly used to inhibit PKR, {8-(imidazol-4-ylmethylene)-6H-azolidino[5,4-g] benzothiazol-7-one}, protects neurons by inhibiting cyclin-dependent kinase. The European Journal of Neuroscience. 28: 2003-16. PMID 19046382 DOI: 10.1111/j.1460-9568.2008.06491.x  0.846
2008 Balderamos M, Ankati H, Akubathini SK, Patel AV, Kamila S, Mukherjee C, Wang L, Biehl ER, D'Mello SR. Synthesis and structure-activity relationship studies of 3-substituted indolin-2-ones as effective neuroprotective agents. Experimental Biology and Medicine (Maywood, N.J.). 233: 1395-402. PMID 18957634 DOI: 10.3181/0805-RM-153  0.334
2008 Majdzadeh N, Wang L, Morrison BE, Bassel-Duby R, Olson EN, D'Mello SR. HDAC4 inhibits cell-cycle progression and protects neurons from cell death. Developmental Neurobiology. 68: 1076-92. PMID 18498087 DOI: 10.1002/Dneu.20637  0.843
2008 Morrison BE, D'Mello SR. Polydactyly in mice lacking HDAC9/HDRP. Experimental Biology and Medicine (Maywood, N.J.). 233: 980-8. PMID 18480421 DOI: 10.3181/0802-RM-48  0.72
2008 Zhang X, Chen HM, Jaramillo E, Wang L, D'Mello SR. Histone deacetylase-related protein inhibits AES-mediated neuronal cell death by direct interaction. Journal of Neuroscience Research. 86: 2423-31. PMID 18438919 DOI: 10.1002/jnr.21680  0.859
2008 Chen HM, Wang L, D'Mello SR. Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074. Journal of Neurochemistry. 105: 1300-12. PMID 18194435 DOI: 10.1111/j.1471-4159.2008.05226.x  0.841
2008 Majdzadeh N, Morrison BE, D'Mello SR. Class IIA HDACs in the regulation of neurodegeneration. Frontiers in Bioscience : a Journal and Virtual Library. 13: 1072-82. PMID 17981613 DOI: 10.2741/2745  0.812
2008 Koulich E, Nguyen T, Johnson K, Giardina CA, D'Mello SR. NF-κB is involved in the survival of cerebellar granule neurons: association of IκBβ phosphorylation with cell survival Journal of Neurochemistry. 77: 351-351. DOI: 10.1046/J.1471-4159.2001.00303.X  0.662
2007 Morrison BE, Majdzadeh N, D'Mello SR. Histone deacetylases: focus on the nervous system. Cellular and Molecular Life Sciences : Cmls. 64: 2258-69. PMID 17530170 DOI: 10.1007/S00018-007-7035-9  0.837
2006 Morrison BE, Majdzadeh N, Zhang X, Lyles A, Bassel-Duby R, Olson EN, D'Mello SR. Neuroprotection by histone deacetylase-related protein. Molecular and Cellular Biology. 26: 3550-64. PMID 16611996 DOI: 10.1128/Mcb.26.9.3550-3564.2006  0.846
2006 Liu L, D'Mello SR. Phosphorylation of IkappaB-beta is necessary for neuronal survival. The Journal of Biological Chemistry. 281: 1506-15. PMID 16286457 DOI: 10.1074/jbc.M510402200  0.498
2005 Chin PC, Majdzadeh N, D'Mello SR. Inhibition of GSK3beta is a common event in neuroprotection by different survival factors. Brain Research. Molecular Brain Research. 137: 193-201. PMID 15950778 DOI: 10.1016/J.Molbrainres.2005.03.004  0.823
2005 Johnson K, Liu L, Majdzadeh N, Chavez C, Chin PC, Morrison B, Wang L, Park J, Chugh P, Chen HM, D'Mello SR. Inhibition of neuronal apoptosis by the cyclin-dependent kinase inhibitor GW8510: identification of 3' substituted indolones as a scaffold for the development of neuroprotective drugs. Journal of Neurochemistry. 93: 538-48. PMID 15836613 DOI: 10.1111/J.1471-4159.2004.03004.X  0.769
2005 D'Mello SR, Chin PC. Treating neurodegenerative conditions through the understanding of neuronal apoptosis. Current Drug Targets. Cns and Neurological Disorders. 4: 3-23. PMID 15723610 DOI: 10.2174/1568007053005118  0.786
2005 Johnson K, D'Mello SR. p21-Activated kinase-1 is necessary for depolarization-mediated neuronal survival. Journal of Neuroscience Research. 79: 809-15. PMID 15693023 DOI: 10.1002/Jnr.20415  0.751
2005 Chin PC, D'Mello SR. Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis. Frontiers in Bioscience : a Journal and Virtual Library. 10: 552-68. PMID 15574392  0.789
2004 Ferrante RJ, Ryu H, Kubilus JK, D'Mello S, Sugars KL, Lee J, Lu P, Smith K, Browne S, Beal MF, Kristal BS, Stavrovskaya IG, Hewett S, Rubinsztein DC, Langley B, et al. Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10335-42. PMID 15548647 DOI: 10.1523/Jneurosci.2599-04.2004  0.402
2004 Chin PC, D'Mello SR. Survival of cultured cerebellar granule neurons can be maintained by Akt-dependent and Akt-independent signaling pathways. Brain Research. Molecular Brain Research. 127: 140-5. PMID 15306131 DOI: 10.1016/J.Molbrainres.2004.02.029  0.749
2004 Chin PC, Liu L, Morrison BE, Siddiq A, Ratan RR, Bottiglieri T, D'Mello SR. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. Journal of Neurochemistry. 90: 595-608. PMID 15255937 DOI: 10.1111/J.1471-4159.2004.02530.X  0.858
2003 Meng F, D'Mello SR. NF-kappaB stimulates Akt phosphorylation and gene expression by distinct signaling mechanisms. Biochimica Et Biophysica Acta. 1630: 35-40. PMID 14580677 DOI: 10.1016/J.Bbaexp.2003.09.001  0.576
2003 Yalcin A, Koulich E, Mohamed S, Liu L, D'Mello SR. Apoptosis in cerebellar granule neurons is associated with reduced interaction between CREB-binding protein and NF-kappaB. Journal of Neurochemistry. 84: 397-408. PMID 12559002 DOI: 10.1046/J.1471-4159.2003.01540.X  0.567
2002 Meng F, Liu L, Chin PC, D'Mello SR. Akt is a downstream target of NF-kappa B. The Journal of Biological Chemistry. 277: 29674-80. PMID 12052823 DOI: 10.1074/Jbc.M112464200  0.759
2001 Kumari S, Liu X, Nguyen T, Zhang X, D'Mello SR. Distinct phosphorylation patterns underlie Akt activation by different survival factors in neurons. Brain Research. Molecular Brain Research. 96: 157-62. PMID 11731021 DOI: 10.1016/S0006-8993(01)03045-1  0.665
2001 Mitchell BD, Gibbons B, Allen LR, Stella J, D'Mello SR. Aberrant apoptosis in the neurological mutant Flathead is associated with defective cytokinesis of neural progenitor cells. Brain Research. Developmental Brain Research. 130: 53-63. PMID 11557093 DOI: 10.1016/S0165-3806(01)00206-1  0.338
2001 Koulich E, Nguyen T, Johnson K, Giardina C, D'mello S. NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival. Journal of Neurochemistry. 76: 1188-98. PMID 11181838 DOI: 10.1046/J.1471-4159.2001.00134.X  0.66
2001 Koulich E, Nguyen T, Johnson K, Giardina CA, D'Mello SR. NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta phosphorylation with cell survival. CORRECTION Journal of Neurochemistry. 77: 351-351. DOI: 10.1046/J.1471-4159.2001.T01-1-00303.X  0.664
2000 D'Mello SR, Kuan CY, Flavell RA, Rakic P. Caspase-3 is required for apoptosis-associated DNA fragmentation but not for cell death in neurons deprived of potassium. Journal of Neuroscience Research. 59: 24-31. PMID 10658182 DOI: 10.1002/(Sici)1097-4547(20000101)59:1<24::Aid-Jnr4>3.0.Co;2-8  0.463
1998 Borodezt K, D'Mello SR. Decreased expression of the metabotropic glutamate receptor-4 gene is associated with neuronal apoptosis. Journal of Neuroscience Research. 53: 531-41. PMID 9726424 DOI: 10.1002/(SICI)1097-4547(19980901)53:5<531::AID-JNR3>3.0.CO;2-A  0.373
1998 D'Mello SR, Aglieco F, Roberts MR, Borodezt K, Haycock JW. A DEVD-inhibited caspase other than CPP32 is involved in the commitment of cerebellar granule neurons to apoptosis induced by K+ deprivation. Journal of Neurochemistry. 70: 1809-18. PMID 9572264 DOI: 10.1046/J.1471-4159.1998.70051809.X  0.387
1998 D'Mello SR. Molecular regulation of neuronal apoptosis. Current Topics in Developmental Biology. 39: 187-213. PMID 9476001  0.466
1997 D'Mello SR, Borodezt K, Soltoff SP. Insulin-like growth factor and potassium depolarization maintain neuronal survival by distinct pathways: possible involvement of PI 3-kinase in IGF-1 signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 1548-60. PMID 9030615  0.433
1995 Levick V, Coffey H, D'Mello SR. Opposing effects of thapsigargin on the survival of developing cerebellar granule neurons in culture. Brain Research. 676: 325-35. PMID 7614002 DOI: 10.1016/0006-8993(95)00115-7  0.394
1994 D'Mello SR, Anelli R, Calissano P. Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons. Experimental Cell Research. 211: 332-8. PMID 8143780 DOI: 10.1006/Excr.1994.1095  0.709
1993 D'Mello SR, Galli C. SGP2, ubiquitin, 14K lectin and RP8 mRNAs are not induced in neuronal apoptosis. Neuroreport. 4: 355-8. PMID 8388743  0.493
1993 D'Mello SR, Galli C, Ciotti T, Calissano P. Induction of apoptosis in cerebellar granule neurons by low potassium: inhibition of death by insulin-like growth factor I and cAMP. Proceedings of the National Academy of Sciences of the United States of America. 90: 10989-93. PMID 8248201 DOI: 10.1073/Pnas.90.23.10989  0.679
1992 D'Mello SR, Jiang C, Lamberti C, Martin SC, Heinrich G. Differential regulation of the nerve growth factor and brain-derived neurotrophic factor genes in L929 mouse fibroblasts. Journal of Neuroscience Research. 33: 519-26. PMID 1336558 DOI: 10.1002/Jnr.490330404  0.745
1992 Cartwright M, Martin S, D'Mello S, Heinrich G. The human nerve growth factor gene: structure of the promoter region and expression in L929 fibroblasts. Brain Research. Molecular Brain Research. 15: 67-75. PMID 1331671 DOI: 10.1016/0169-328X(92)90153-3  0.753
1991 D'Mello SR, Heinrich G. Structural and functional identification of regulatory regions and cis elements surrounding the nerve growth factor gene promoter. Brain Research. Molecular Brain Research. 11: 255-64. PMID 1661823 DOI: 10.1016/0169-328X(91)90034-U  0.739
1991 D'Mello SR, Heinrich G. Multiple signalling pathways interact in the regulation of nerve growth factor production in L929 fibroblasts. Journal of Neurochemistry. 57: 1570-6. PMID 1655978  0.749
1990 D'Mello SR, Heinrich G. Induction of nerve growth factor gene expression by 12-O-tetradecanoyl phorbol 13-acetate. Journal of Neurochemistry. 55: 718-21. PMID 2370555 DOI: 10.1111/J.1471-4159.1990.Tb04192.X  0.752
1989 D'Mello SR, Turzai LM, Gioio AE, Kaplan BB. Isolation and structural characterization of the bovine tyrosine hydroxylase gene. Journal of Neuroscience Research. 23: 31-40. PMID 2568495 DOI: 10.1002/jnr.490230105  0.526
1988 Batter DK, D'Mello SR, Turzai LM, Hughes HB, Gioio AE, Kaplan BB. The complete nucleotide sequence and structure of the gene encoding bovine phenylethanolamine N-methyltransferase. Journal of Neuroscience Research. 19: 367-76. PMID 3379652 DOI: 10.1002/jnr.490190313  0.524
1988 D'Mello SR, Weisberg EP, Stachowiak MK, Turzai LM, Gioio AE, Kaplan BB. Isolation and nucleotide sequence of a cDNA clone encoding bovine adrenal tyrosine hydroxylase: comparative analysis of tyrosine hydroxylase gene products. Journal of Neuroscience Research. 19: 440-9. PMID 2898537 DOI: 10.1002/jnr.490190408  0.524
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