Zhiyan Xiao, Ph.D. - Publications

Affiliations: 
2003 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy

44 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Nan G, Huang L, Li Y, Yang Y, Yang Y, Li K, Lai F, Chen X, Xiao Z. Identification of N, C-capped di- and tripeptides as selective immunoproteasome inhibitors. European Journal of Medicinal Chemistry. 234: 114252. PMID 35286927 DOI: 10.1016/j.ejmech.2022.114252  0.367
2022 Zhang L, Tian J, Cheng H, Yang Y, Yang Y, Ye F, Xiao Z. Identification of novel xanthine oxidase inhibitors via virtual screening with enhanced characterization of molybdopterin binding groups. European Journal of Medicinal Chemistry. 230: 114101. PMID 35063733 DOI: 10.1016/j.ejmech.2022.114101  0.34
2021 Dong J, Pan X, Yang Y, Zhang G, Xiao Z, Liu Z. Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors. European Journal of Medicinal Chemistry. 223: 113631. PMID 34147748 DOI: 10.1016/j.ejmech.2021.113631  0.365
2021 Zhang H, Jing L, Liu M, Goto M, Lai F, Liu X, Sheng L, Yang Y, Yang Y, Li Y, Chen X, Lee KH, Xiao Z. Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors. European Journal of Medicinal Chemistry. 223: 113634. PMID 34147745 DOI: 10.1016/j.ejmech.2021.113634  0.582
2020 Yang Y, Zhang L, Tian J, Ye F, Xiao Z. Identification of xanthine oxidase inhibitors through hierarchical virtual screening. Rsc Advances. 10: 27752-27763. PMID 35516940 DOI: 10.1039/d0ra03143g  0.313
2020 Yang Y, Wang K, Wu B, Yang Y, Lai F, Chen X, Xiao Z. Design, synthesis and biological evaluation of triaryl compounds as novel 20S proteasome inhibitors. Bioorganic & Medicinal Chemistry Letters. 127508. PMID 32853683 DOI: 10.1016/J.Bmcl.2020.127508  0.475
2020 Zhang L, Lai F, Chen X, Xiao Z. Identification of potential indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors by an FBG-based 3D QSAR pharmacophore model. Journal of Molecular Graphics & Modelling. 99: 107628. PMID 32387857 DOI: 10.1016/J.Jmgm.2020.107628  0.448
2020 Yang Y, Tian JY, Ye F, Xiao Z. Identification of natural products as selective PTP1B inhibitors via virtual screening. Bioorganic Chemistry. 98: 103706. PMID 32199302 DOI: 10.1016/J.Bioorg.2020.103706  0.431
2020 Yang Y, Zhang L, Tian J, Ye F, Xiao Z. Identification of xanthine oxidase inhibitors through hierarchical virtual screening Rsc Advances. 10: 27752-27763. DOI: 10.1039/D0Ra03143G  0.416
2019 Liu Z, Yang Y, Dong W, Liu Q, Wang R, Pang J, Xia X, Zhu X, Liu S, Shen Z, Xiao Z, Liu Y. Investigation on the Enzymatic Profile of Mulberry Alkaloids by Enzymatic Study and Molecular Docking. Molecules (Basel, Switzerland). 24. PMID 31071910 DOI: 10.3390/Molecules24091776  0.355
2018 Tang Y, Zhang X, Chen Z, Yin W, Nan G, Tian J, Ye F, Xiao Z. Novel benzamido derivatives as PTP1B inhibitors with anti-hyperglycemic and lipid-lowering efficacy. Acta Pharmaceutica Sinica. B. 8: 919-932. PMID 30505661 DOI: 10.1016/J.Apsb.2018.05.001  0.424
2018 Sun Z, Zhou T, Pan X, Yang Y, Huan Y, Xiao Z, Shen Z, Liu Z. Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings. Bioorganic & Medicinal Chemistry Letters. PMID 30097366 DOI: 10.1016/J.Bmcl.2018.07.048  0.446
2018 Jing L, Tang Y, Goto M, Lee KH, Xiao Z. SAR study on ,-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents. Rsc Advances. 8: 11871-11885. PMID 29682280 DOI: 10.1039/C8Ra01440J  0.599
2018 Jing L, Tang Y, Xiao Z. Discovery of novel CDK inhibitors via scaffold hopping from CAN508. Bioorganic & Medicinal Chemistry Letters. PMID 29550093 DOI: 10.1016/J.Bmcl.2018.02.054  0.491
2017 Zhou A, Yan L, Lai F, Chen X, Goto M, Lee KH, Xiao Z. Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds. Bioorganic & Medicinal Chemistry Letters. PMID 28625363 DOI: 10.1016/J.Bmcl.2017.06.019  0.55
2017 Lu X, Pan X, Yang Y, Ji M, Chen X, Xiao Z, Liu Z. Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carboline moieties. European Journal of Medicinal Chemistry. 135: 260-269. PMID 28456034 DOI: 10.1016/J.Ejmech.2017.04.061  0.458
2017 Xie K, Dou X, Chen R, Chen D, Fang C, Xiao Z, Dai J. Molecular Characterization and Phylogenetic Analysis of Two Novel Fungal Phenolic UDP-Glycosyltransferases from Absidia coerulea and Rhizopus japonicus. Applied and Environmental Microbiology. PMID 28159792 DOI: 10.1128/Aem.03103-16  0.488
2016 Kang J, Tang Y, Liu Q, Guo N, Zhang J, Xiao Z, Chen R, Shen Z. Isolation, modification, and aldose reductase inhibitory activity of rosmarinic acid derivatives from the roots of Salvia grandifolia. Fitoterapia. PMID 27233987 DOI: 10.1016/j.fitote.2016.05.011  0.345
2015 Fang C, Xiao Z. Receptor-based 3D-QSAR in Drug Design: Methods and Applications in Kinase Studies. Current Topics in Medicinal Chemistry. PMID 26369822 DOI: 10.2174/1568026615666150915120943  0.503
2015 Xiao Z, Morris-Natschke SL, Lee KH. Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates. Medicinal Research Reviews. PMID 26359649 DOI: 10.1002/med.21377  0.392
2015 Xu K, Wang K, Yang Y, Yan DA, Huang L, Chen CH, Xiao Z. Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome. European Journal of Medicinal Chemistry. 98: 61-8. PMID 26005024 DOI: 10.1016/J.Ejmech.2015.05.023  0.471
2015 Gao J, Fang C, Xiao Z, Huang L, Chen CH, Wang LT, Lee KH. Discovery of novel 5-fluoro-N (2),N (4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9. Medchemcomm. 6: 444-454. PMID 25914804 DOI: 10.1039/C4Md00412D  0.668
2015 Yan L, Lai F, Chen X, Xiao Z. Discovery of novel indirubin-3'-monoxime derivatives as potent inhibitors against CDK2 and CDK9. Bioorganic & Medicinal Chemistry Letters. 25: 2447-51. PMID 25908517 DOI: 10.1016/J.Bmcl.2015.03.066  0.493
2014 Wu SY, Pan SL, Xiao ZY, Hsu JL, Chen MC, Lee KH, Teng CM. NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells. Plos One. 9: e112220. PMID 25372714 DOI: 10.1371/journal.pone.0112220  0.43
2014 Tang YB, Liu JZ, Zhang SE, Du X, Nie F, Tian JY, Ye F, Huang K, Hu JP, Li Y, Xiao Z. 3-Phenylpropanoic acid-based phosphotyrosine (pTyr) mimetics: hit evolution to a novel orally active protein tyrosine phosphatase 1B (PTP1B) inhibitor. Chemmedchem. 9: 918-21. PMID 24644278 DOI: 10.1002/Cmdc.201400007  0.381
2014 Tang Y, Liu J, Zhang S, Du X, Nie F, Tian J, Ye F, Huang K, Hu J, Li Y, Xiao Z. Back Cover: 3-Phenylpropanoic Acid-Based Phosphotyrosine (pTyr) Mimetics: Hit Evolution to a Novel Orally Active Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitor (ChemMedChem 5/2014) Chemmedchem. 9: 1084-1084. DOI: 10.1002/Cmdc.201490019  0.346
2013 Liu JZ, Zhang SE, Nie F, Yang Y, Tang YB, Yin W, Tian JY, Ye F, Xiao Z. Discovery of novel PTP1B inhibitors via pharmacophore-oriented scaffold hopping from Ertiprotafib. Bioorganic & Medicinal Chemistry Letters. 23: 6217-22. PMID 24148325 DOI: 10.1016/J.Bmcl.2013.10.002  0.472
2013 Wei S, Tang YB, Hua H, Ohkoshi E, Goto M, Wang LT, Lee KH, Xiao Z. Discovery of novel andrographolide derivatives as cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 23: 4056-60. PMID 23768904 DOI: 10.1016/J.Bmcl.2013.05.061  0.564
2013 Tang YB, Lu D, Chen Z, Hu C, Yang Y, Tian JY, Ye F, Wu L, Zhang ZY, Xiao Z. Design, synthesis and insulin-sensitising effects of novel PTP1B inhibitors. Bioorganic & Medicinal Chemistry Letters. 23: 2313-8. PMID 23499238 DOI: 10.1016/J.Bmcl.2013.02.073  0.471
2012 Li J, Hua HM, Tang YB, Zhang S, Ohkoshi E, Lee KH, Xiao Zy. Synthesis and evaluation of novel podophyllotoxin analogs. Bioorganic & Medicinal Chemistry Letters. 22: 4293-5. PMID 22658864 DOI: 10.1016/J.Bmcl.2012.05.033  0.544
2012 Xu K, Xiao Z, Tang YB, Huang L, Chen CH, Ohkoshi E, Lee KH. Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2772-4. PMID 22437113 DOI: 10.1016/J.Bmcl.2012.02.086  0.619
2012 Chen MC, Pan SL, Shi Q, Xiao Z, Lee KH, Li TK, Teng CM. QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. Cancer Science. 103: 80-7. PMID 21920000 DOI: 10.1111/j.1349-7006.2011.02103.x  0.404
2011 Fang C, Xiao Z, Guo Z. Generation and validation of the first predictive pharmacophore model for cyclin-dependent kinase 9 inhibitors. Journal of Molecular Graphics & Modelling. 29: 800-8. PMID 21333571 DOI: 10.1016/J.Jmgm.2011.01.003  0.539
2005 Lai YY, Huang LJ, Lee KH, Xiao Z, Bastow KF, Yamori T, Kuo SC. Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents. Bioorganic & Medicinal Chemistry. 13: 265-75. PMID 15582470 DOI: 10.1016/j.bmc.2004.09.041  0.468
2004 Xiao Z, Bastow KF, Vance JR, Sidwell RS, Wang HK, Chen MS, Shi Q, Lee KH. Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4β-[(4″-benzamido)-amino]-4′-O-demethyl- epipodophyllotoxin derivatives Journal of Medicinal Chemistry. 47: 5140-5148. PMID 15456257 DOI: 10.1021/jm030609l  0.531
2004 Zhu XK, Guan J, Xiao Z, Cosentino LM, Lee KH. Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives. Bioorganic & Medicinal Chemistry. 12: 4267-73. PMID 15246103 DOI: 10.1016/j.bmc.2004.04.048  0.445
2004 Xiao Z, Vance JR, Bastow KF, Brossi A, Wang HK, Lee KH. Antitumor agents. Part 235: Novel 4′-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential Bioorganic and Medicinal Chemistry. 12: 3363-3369. PMID 15158805 DOI: 10.1016/j.bmc.2004.03.056  0.519
2004 Xiao Z, Bastow KF, Vance JR, Lee KH. Antitumor agents. Part 227: Studies on novel 4′-O-demethyl- epipodophyllotoxins as antitumor agents targeting topoisomerase II Bioorganic and Medicinal Chemistry. 12: 3339-3344. PMID 15158802 DOI: 10.1016/j.bmc.2004.03.067  0.489
2004 Han S, Xiao Z, Bastow KF, Lee KH. Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 2979-82. PMID 15125972 DOI: 10.1016/j.bmcl.2004.02.102  0.506
2004 Xiao Z, Han S, Bastow KF, Lee KH. Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. Bioorganic & Medicinal Chemistry Letters. 14: 1581-4. PMID 15006408 DOI: 10.1016/j.bmcl.2003.12.096  0.503
2003 Ohtsu H, Itokawa H, Xiao Z, Su CY, Shih CC, Chiang T, Chang E, Lee Y, Chiu SY, Chang C, Lee KH. Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids. Bioorganic & Medicinal Chemistry. 11: 5083-90. PMID 14604672 DOI: 10.1016/J.Bmc.2003.08.029  0.462
2003 Golbraikh A, Shen M, Xiao Z, Xiao YD, Lee KH, Tropsha A. Rational selection of training and test sets for the development of validated QSAR models. Journal of Computer-Aided Molecular Design. 17: 241-53. PMID 13677490 DOI: 10.1023/A:1025386326946  0.392
2002 Ohtsu H, Xiao Z, Ishida J, Nagai M, Wang HK, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee Y, Tsai MY, Chang C, Lee KH. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. Journal of Medicinal Chemistry. 45: 5037-42. PMID 12408714 DOI: 10.1021/Jm020200G  0.455
2002 Xiao Z, Xiao YD, Feng J, Golbraikh A, Tropsha A, Lee KH. Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method. Journal of Medicinal Chemistry. 45: 2294-309. PMID 12014968 DOI: 10.1021/Jm0105427  0.415
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