Yizhou Dong, Ph.D. - Publications

2009 Pharmaceutical Sciences University of North Carolina, Chapel Hill, Chapel Hill, NC 
Pharmaceutical Chemistry, Pharmacology

45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Hou X, Zhang X, Zhao W, Zeng C, Deng B, McComb DW, Du S, Zhang C, Li W, Dong Y. Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis. Nature Nanotechnology. 15: 41-46. PMID 31907443 DOI: 10.1038/s41565-019-0600-1  0.6
2019 Li B, Niu Y, Ji W, Dong Y. Strategies for the CRISPR-Based Therapeutics. Trends in Pharmacological Sciences. PMID 31862124 DOI: 10.1016/j.tips.2019.11.006  0.6
2019 Zhang C, Zhao W, Bian C, Hou X, Deng B, McComb DW, Chen X, Dong Y. Antibiotic-Derived Lipid Nanoparticles to Treat Intracellular . Acs Applied Bio Materials. 2: 1270-1277. PMID 31750420 DOI: 10.1021/acsabm.8b00821  0.52
2019 Zhang C, Zhang X, Zhao W, Zeng C, Li W, Li B, Luo X, Li J, Jiang J, Deng B, McComb DW, Dong Y. Chemotherapy drugs derived nanoparticles encapsulating mRNA encoding tumor suppressor proteins to treat triple-negative breast cancer. Nano Research. 12: 855-861. PMID 31737223 DOI: 10.1007/s12274-019-2308-9  0.6
2019 Zhao W, Hou X, Vick OG, Dong Y. RNA delivery biomaterials for the treatment of genetic and rare diseases. Biomaterials. 217: 119291. PMID 31255978 DOI: 10.1016/j.biomaterials.2019.119291  0.52
2019 Zhang Y, Zhang X, Zeng C, Li B, Zhang C, Li W, Hou X, Dong Y. Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR). Bioorganic & Medicinal Chemistry. PMID 31005367 DOI: 10.1016/j.bmc.2019.04.019  0.6
2018 Luo X, Zhao W, Li B, Zhang X, Zhang C, Bratasz A, Deng B, McComb DW, Dong Y. Co-delivery of mRNA and SPIONs through amino-ester nanomaterials. Nano Research. 11: 5596-5603. PMID 31737222 DOI: 10.1007/s12274-018-2082-0  0.6
2018 Zhang X, Zhang C, Yang X, Hou X, Zhao W, Benson D, Yu J, Dong Y. Design, synthesis and evaluation of anti-CD38 antibody drug conjugate based on Daratumumab and maytansinoid. Bioorganic & Medicinal Chemistry. PMID 30594452 DOI: 10.1016/j.bmc.2018.12.024  0.6
2018 Li B, Zeng C, Li W, Zhang X, Luo X, Zhao W, Zhang C, Dong Y. Synthetic Oligonucleotides Inhibit CRISPR-Cpf1-Mediated Genome Editing. Cell Reports. 25: 3262-3272.e3. PMID 30566855 DOI: 10.1016/j.celrep.2018.11.079  0.6
2018 Zhao W, Zhang C, Li B, Zhang X, Luo X, Zeng C, Li W, Gao M, Dong Y. Lipid Polymer Hybrid Nanomaterials for mRNA Delivery. Cellular and Molecular Bioengineering. 11: 397-406. PMID 30555598 DOI: 10.1007/s12195-018-0536-9  0.6
2018 Zhang X, Zhao W, Li B, Li W, Zhang C, Hou X, Jiang J, Dong Y. Ratiometric fluorescent probes for capturing endogenous hypochlorous acid in the lungs of mice. Chemical Science. 9: 8207-8212. PMID 30542568 DOI: 10.1039/c8sc03226b  0.6
2018 Li B, Zhang X, Dong Y. Nanoscale platforms for messenger RNA delivery. Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology. e1530. PMID 29726120 DOI: 10.1002/wnan.1530  0.6
2018 Li B, Zeng C, Dong Y. Design and assessment of engineered CRISPR-Cpf1 and its use for genome editing. Nature Protocols. 13: 899-914. PMID 29622802 DOI: 10.1038/nprot.2018.004  0.6
2017 Guo S, Li H, Ma M, Fu J, Dong Y, Guo P. Size, Shape, and Sequence-Dependent Immunogenicity of RNA Nanoparticles. Molecular Therapy. Nucleic Acids. 9: 399-408. PMID 29246318 DOI: 10.1016/j.omtn.2017.10.010  0.4
2017 Li B, Zhao W, Luo X, Zhang X, Li C, Zeng C, Dong Y. Engineering CRISPR-Cpf1 crRNAs and mRNAs to maximize genome editing efficiency. Nature Biomedical Engineering. 1. PMID 28840077 DOI: 10.1038/s41551-017-0066  0.6
2017 Zhang X, Chen X, Zhao W, Zeng C, Luo X, Li W, Li B, Jiang J, Dong Y. GalNAc conjugated atorvastatin with enhanced water solubility and cellular internalization. Bioconjugate Chemistry. PMID 28745862 DOI: 10.1021/acs.bioconjchem.7b00295  0.6
2017 Li B, Dong Y. Preparation and Optimization of Lipid-Like Nanoparticles for mRNA Delivery. Methods in Molecular Biology (Clifton, N.J.). 1632: 207-217. PMID 28730441 DOI: 10.1007/978-1-4939-7138-1_13  0.6
2017 Zhang X, Li B, Luo X, Zhao W, Jiang J, Zhang C, Gao M, Chen X, Dong Y. Biodegradable Amino-ester Nanomaterials for Cas9 mRNA Delivery in Vitro and in Vivo. Acs Applied Materials & Interfaces. PMID 28685575 DOI: 10.1021/acsami.7b08163  0.6
2017 Jiang C, Mei M, Li B, Zhu X, Zu W, Tian Y, Wang Q, Guo Y, Dong Y, Tan X. A non-viral CRISPR/Cas9 delivery system for therapeutic gene targeting in vivo. Cell Research. PMID 28117345 DOI: 10.1038/cr.2017.16  0.6
2016 Li B, Zhao W, Zhang X, Wang J, Luo X, Baker SD, Jordan CT, Dong Y. Design, synthesis and evaluation of anti-CD123 antibody drug conjugates. Bioorganic & Medicinal Chemistry. PMID 27687970 DOI: 10.1016/j.bmc.2016.09.043  0.6
2016 Li B, Luo X, Deng B, Giancola JB, McComb DW, Schmittgen TD, Dong Y. Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA. Scientific Reports. 6: 22137. PMID 26916931 DOI: 10.1038/srep22137  0.6
2016 Li B, Luo X, Dong Y. Effects of Chemically Modified Messenger RNA on Protein Expression. Bioconjugate Chemistry. PMID 26906521 DOI: 10.1021/acs.bioconjchem.6b00090  0.6
2016 Yin H, Song CQ, Dorkin JR, Zhu LJ, Li Y, Wu Q, Park A, Yang J, Suresh S, Bizhanova A, Gupta A, Bolukbasi MF, Walsh S, Bogorad RL, Gao G, ... ... Dong Y, et al. Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo. Nature Biotechnology. PMID 26829318 DOI: 10.1038/nbt.3471  0.64
2016 Dong Y, Dorkin JR, Wang W, Chang PH, Webber MJ, Tang BC, Yang J, Abutbul-Ionita I, Danino D, DeRosa F, Heartlein M, Langer R, Anderson DG. Poly(glycoamidoamine) brushes formulated nanomaterials for systemic siRNA and mRNA delivery in vivo. Nano Letters. PMID 26727632 DOI: 10.1021/acs.nanolett.5b02428  0.64
2015 Li B, Luo X, Deng B, Wang J, McComb DW, Shi Y, Gaensler KM, Tan X, Dunn A, Kerlin B, Dong Y. An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in vivo. Nano Letters. PMID 26529392 DOI: 10.1021/acs.nanolett.5b03528  0.6
2015 Khan OF, Zaia EW, Jhunjhunwala S, Xue W, Cai W, Yun DS, Barnes CM, Dahlman JE, Dong Y, Pelet JM, Webber MJ, Tsosie JK, Jacks TE, Langer R, Anderson DG. Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature. Nano Letters. 15: 3008-16. PMID 25789998 DOI: 10.1021/nl5048972  0.64
2014 Eltoukhy AA, Chen D, Veiseh O, Pelet JM, Yin H, Dong Y, Anderson DG. Nucleic acid-mediated intracellular protein delivery by lipid-like nanoparticles. Biomaterials. 35: 6454-61. PMID 24831975 DOI: 10.1016/j.biomaterials.2014.04.014  0.64
2014 Dahlman JE, Barnes C, Khan OF, Thiriot A, Jhunjunwala S, Shaw TE, Xing Y, Sager HB, Sahay G, Speciner L, Bader A, Bogorad RL, Yin H, Racie T, Dong Y, et al. In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight. Nature Nanotechnology. 9: 648-55. PMID 24813696 DOI: 10.1038/nnano.2014.84  0.64
2014 Dong Y, Eltoukhy AA, Alabi CA, Khan OF, Veiseh O, Dorkin JR, Sirirungruang S, Yin H, Tang BC, Pelet JM, Chen D, Gu Z, Xue Y, Langer R, Anderson DG. Lipid-like nanomaterials for simultaneous gene expression and silencing in vivo. Advanced Healthcare Materials. 3: 1392-7. PMID 24623658 DOI: 10.1002/adhm.201400054  0.64
2014 Dong Y, Love KT, Dorkin JR, Sirirungruang S, Zhang Y, Chen D, Bogorad RL, Yin H, Chen Y, Vegas AJ, Alabi CA, Sahay G, Olejnik KT, Wang W, Schroeder A, et al. Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates. Proceedings of the National Academy of Sciences of the United States of America. 111: 3955-60. PMID 24516150 DOI: 10.1073/pnas.1322937111  0.64
2013 Gu Z, Dang TT, Ma M, Tang BC, Cheng H, Jiang S, Dong Y, Zhang Y, Anderson DG. Glucose-responsive microgels integrated with enzyme nanocapsules for closed-loop insulin delivery. Acs Nano. 7: 6758-66. PMID 23834678 DOI: 10.1021/nn401617u  0.64
2013 Zhang Y, Pelet JM, Heller DA, Dong Y, Chen D, Gu Z, Joseph BJ, Wallas J, Anderson DG. Lipid-modified aminoglycoside derivatives for in vivo siRNA delivery. Advanced Materials (Deerfield Beach, Fla.). 25: 4641-5. PMID 23813808 DOI: 10.1002/adma.201301917  0.64
2012 Lee KH, Morris-Natschke S, Qian K, Dong Y, Yang X, Zhou T, Belding E, Wu SF, Wada K, Akiyama T. Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng). Journal of Traditional and Complementary Medicine. 2: 6-26. PMID 24716110  0.88
2012 Wang LT, Pan SL, Chen TH, Dong Y, Lee KH, Teng CM. DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells. Chembiochem : a European Journal of Chemical Biology. 13: 1663-72. PMID 22761044 DOI: 10.1002/cbic.201200191  0.88
2012 Chen D, Love KT, Chen Y, Eltoukhy AA, Kastrup C, Sahay G, Jeon A, Dong Y, Whitehead KA, Anderson DG. Rapid discovery of potent siRNA-containing lipid nanoparticles enabled by controlled microfluidic formulation. Journal of the American Chemical Society. 134: 6948-51. PMID 22475086 DOI: 10.1021/ja301621z  0.64
2012 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Kim Y, Lee EY, Lee KH. Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility. Journal of Natural Products. 75: 370-7. PMID 22304236 DOI: 10.1021/np2007878  0.64
2011 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity. Bioorganic & Medicinal Chemistry Letters. 21: 2341-4. PMID 21420855 DOI: 10.1016/j.bmcl.2011.02.084  0.64
2011 Dong Y, Morris-Natschke SL, Lee KH. Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents. Natural Product Reports. 28: 529-42. PMID 21225077 DOI: 10.1039/c0np00035c  0.88
2011 Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EY, Bastow KF, Lee KH. Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 52-7. PMID 21147529 DOI: 10.1016/j.bmcl.2010.11.077  0.64
2011 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 546-9. PMID 21087859 DOI: 10.1016/j.bmcl.2010.10.074  0.64
2010 Chou LC, Tsai MT, Hsu MH, Wang SH, Way TD, Huang CH, Lin HY, Qian K, Dong Y, Lee KH, Huang LJ, Kuo SC. Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents. Journal of Medicinal Chemistry. 53: 8047-58. PMID 20973552 DOI: 10.1021/jm100780c  0.88
2010 Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 20: 4085-7. PMID 20542429 DOI: 10.1016/j.bmcl.2010.05.079  0.64
2010 Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH. Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. Bioorganic & Medicinal Chemistry. 18: 803-8. PMID 20034799 DOI: 10.1016/j.bmc.2009.11.049  0.64
2009 Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Bastow KF, Morris-Natschke SL, Lee KH. Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents. Bioorganic & Medicinal Chemistry Letters. 19: 6289-92. PMID 19819136 DOI: 10.1016/j.bmcl.2009.09.092  0.64
2009 Dong Y, Shi Q, Liu YN, Wang X, Bastow KF, Lee KH. Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents. Journal of Medicinal Chemistry. 52: 3586-90. PMID 19425534 DOI: 10.1021/jm9001567  0.64
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