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John C. Kalvass, Ph.D. - Publications

Affiliations: 
2006 University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Pharmacy, Pharmacology
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2013 Kikuchi R, de Morais SM, Kalvass JC. In vitro P-glycoprotein efflux ratio can predict the in vivo brain penetration regardless of biopharmaceutics drug disposition classification system class. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 2012-7. PMID 24009309 DOI: 10.1124/dmd.113.053868  0.482
2013 Kalvass JC, Polli JW, Bourdet DL, Feng B, Huang SM, Liu X, Smith QR, Zhang LK, Zamek-Gliszczynski MJ. Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position. Clinical Pharmacology and Therapeutics. 94: 80-94. PMID 23588303 DOI: 10.1038/Clpt.2013.34  0.345
2009 Zhao R, Kalvass JC, Pollack GM. Assessment of blood-brain barrier permeability using the in situ mouse brain perfusion technique. Pharmaceutical Research. 26: 1657-64. PMID 19384470 DOI: 10.1007/S11095-009-9876-4  0.667
2009 Zhao R, Kalvass JC, Yanni SB, Bridges AS, Pollack GM. Fexofenadine brain exposure and the influence of blood-brain barrier P-glycoprotein after fexofenadine and terfenadine administration. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 529-35. PMID 19114463 DOI: 10.1124/Dmd.107.019893  0.684
2009 Zamek-Gliszczynski MJ, Kalvass JC, Pollack GM, Brouwer KL. Relationship between drug/metabolite exposure and impairment of excretory transport function. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 386-90. PMID 19022942 DOI: 10.1124/Dmd.108.023648  0.487
2009 Kielbasa W, Kalvass JC, Stratford R. Microdialysis evaluation of atomoxetine brain penetration and central nervous system pharmacokinetics in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 137-42. PMID 18936112 DOI: 10.1124/Dmd.108.023119  0.344
2007 Kalvass JC, Olson ER, Cassidy MP, Selley DE, Pollack GM. Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data. The Journal of Pharmacology and Experimental Therapeutics. 323: 346-55. PMID 17646430 DOI: 10.1124/Jpet.107.119560  0.663
2007 Kalvass JC, Maurer TS, Pollack GM. Use of plasma and brain unbound fractions to assess the extent of brain distribution of 34 drugs: comparison of unbound concentration ratios to in vivo p-glycoprotein efflux ratios. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 660-6. PMID 17237155 DOI: 10.1124/Dmd.106.012294  0.66
2007 Kalvass JC, Pollack GM. Kinetic considerations for the quantitative assessment of efflux activity and inhibition: implications for understanding and predicting the effects of efflux inhibition. Pharmaceutical Research. 24: 265-76. PMID 17191095 DOI: 10.1007/S11095-006-9135-X  0.498
2007 Kalvass JC, Olson ER, Pollack GM. Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 455-9. PMID 17178769 DOI: 10.1124/Dmd.106.011445  0.722
2006 Bauer B, Yang X, Hartz AM, Olson ER, Zhao R, Kalvass JC, Pollack GM, Miller DS. In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation. Molecular Pharmacology. 70: 1212-9. PMID 16837625 DOI: 10.1124/Mol.106.023796  0.719
2006 Turncliff RZ, Hoffmaster KA, Kalvass JC, Pollack GM, Brouwer KL. Hepatobiliary disposition of a drug/metabolite pair: Comprehensive pharmacokinetic modeling in sandwich-cultured rat hepatocytes. The Journal of Pharmacology and Experimental Therapeutics. 318: 881-9. PMID 16690724 DOI: 10.1124/Jpet.106.102616  0.512
2004 Kalvass JC, Graff CL, Pollack GM. Use of loperamide as a phenotypic probe of mdr1a status in CF-1 mice. Pharmaceutical Research. 21: 1867-70. PMID 15553234 DOI: 10.1023/B:Pham.0000045241.26925.8B  0.644
2002 Kalvass JC, Maurer TS. Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery. Biopharmaceutics & Drug Disposition. 23: 327-38. PMID 12415573 DOI: 10.1002/bdd.325  0.397
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