James L. Manley, Ph. D. - Publications

Biological Sciences Columbia University, New York, NY 
mRNA processing

269 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Richard P, Feng S, Tsai YL, Li W, Rinchetti P, Muhith U, Irizarry-Cole J, Stolz K, Sanz LA, Hartono S, Hoque M, Tadesse S, Seitz H, Lotti F, Hirano M, ... ... Manley JL, et al. SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation. Autophagy. PMID 32686621 DOI: 10.1080/15548627.2020.1796292  0.4
2020 Cheng LC, Zheng D, Baljinnyam E, Sun F, Ogami K, Yeung PL, Hoque M, Lu CW, Manley JL, Tian B. Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation. Nature Communications. 11: 3182. PMID 32576858 DOI: 10.1038/S41467-020-16959-2  0.4
2020 Tsai YL, Coady TH, Lu L, Zheng D, Alland I, Tian B, Shneider NA, Manley JL. ALS/FTD-associated protein FUS induces mitochondrial dysfunction by preferentially sequestering respiratory chain complex mRNAs. Genes & Development. PMID 32381627 DOI: 10.1101/Gad.335836.119  0.4
2020 Liu Z, Zhang J, Sun Y, Perea-Chamblee TE, Manley JL, Rabadan R. Pan-cancer analysis identifies mutations in that recapitulate mutant SF3B1 splicing dysregulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 32332164 DOI: 10.1073/Pnas.1922622117  0.56
2019 Zhang J, Ali AM, Lieu YK, Liu Z, Gao J, Rabadan R, Raza A, Mukherjee S, Manley JL. Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1. Molecular Cell. PMID 31474574 DOI: 10.1016/J.Molcel.2019.07.017  0.56
2019 Yamazaki T, Liu L, Lazarev D, Al-Zain A, Fomin V, Yeung PL, Chambers SM, Lu CW, Studer L, Manley JL. Corrigendum: TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency. Genes & Development. 33: 733-736. PMID 31160395 DOI: 10.1101/Gad.326983.119  0.36
2018 Carbone M, Amelio I, Affar EB, Brugarolas J, Cannon-Albright LA, Cantley LC, Cavenee WK, Chen Z, Croce CM, Andrea A, Gandara D, Giorgi C, Jia W, Lan Q, Mak TW, ... Manley JL, et al. Consensus report of the 8 and 9th Weinman Symposia on Gene x Environment Interaction in carcinogenesis: novel opportunities for precision medicine. Cell Death and Differentiation. PMID 30323273 DOI: 10.1038/S41418-018-0213-5  1
2018 Fomin V, Richard P, Hoque M, Li C, Gu Z, Fissore-O'Leary M, Tian B, Prives C, Manley JL. The gene, implicated in ALS/FTD, encodes a protein that functions in control of endothelin and glutamate signaling. Molecular and Cellular Biology. PMID 30150298 DOI: 10.1128/Mcb.00155-18  0.72
2018 Yamazaki T, Liu L, Lazarev D, Al-Zain A, Fomin V, Yeung PL, Chambers SM, Lu CW, Studer L, Manley JL. TCF3 alternative splicing controlled by hnRNP H/F regulates E-cadherin expression and hESC pluripotency. Genes & Development. PMID 30115631 DOI: 10.1101/Gad.316984.118  0.36
2017 Yurko N, Liu X, Yamazaki T, Hoque M, Tian B, Manley JL. MPK1/SLT2 Links Multiple Stress Responses with Gene Expression in Budding Yeast by Phosphorylating Tyr1 of the RNAP II CTD. Molecular Cell. 68: 913-925.e3. PMID 29220656 DOI: 10.1016/J.Molcel.2017.11.020  0.4
2017 Sun Y, Zhang Y, Hamilton K, Manley JL, Shi Y, Walz T, Tong L. Molecular basis for the recognition of the human AAUAAA polyadenylation signal. Proceedings of the National Academy of Sciences of the United States of America. PMID 29208711 DOI: 10.1073/pnas.1718723115  0.56
2017 Liu X, Hoque M, Larochelle M, Lemay JF, Yurko N, Manley JL, Bachand F, Tian B. Comparative analysis of alternative polyadenylation in S. cerevisiae and S. pombe. Genome Research. PMID 28916539 DOI: 10.1101/Gr.222331.117  0.4
2017 Ogami K, Richard P, Chen Y, Hoque M, Li W, Moresco JJ, Yates JR, Tian B, Manley JL. An Mtr4/ZFC3H1 complex facilitates turnover of unstable nuclear RNAs to prevent their cytoplasmic transport and global translational repression. Genes & Development. PMID 28733371 DOI: 10.1101/Gad.302604.117  0.4
2016 Tian B, Manley JL. Alternative polyadenylation of mRNA precursors. Nature Reviews. Molecular Cell Biology. PMID 27677860 DOI: 10.1038/Nrm.2016.116  0.4
2016 Conlon EG, Lu L, Sharma A, Yamazaki T, Tang T, Shneider NA, Manley JL. The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS patient brains. Elife. 5. PMID 27623008 DOI: 10.7554/Elife.17820  1
2016 Morales JC, Richard P, Patidar PL, Motea EA, Dang TT, Manley JL, Boothman DA. XRN2 Links Transcription Termination to DNA Damage and Replication Stress. Plos Genetics. 12: e1006107. PMID 27437695 DOI: 10.1371/Journal.Pgen.1006107  0.96
2015 Zhang J, Lieu YK, Ali AM, Penson A, Reggio KS, Rabadan R, Raza A, Mukherjee S, Manley JL. Disease-associated mutation in SRSF2 misregulates splicing by altering RNA-binding affinities. Proceedings of the National Academy of Sciences of the United States of America. PMID 26261309 DOI: 10.1073/Pnas.1514105112  1
2015 Coady TH, Manley JL. ALS mutations in TLS/FUS disrupt target gene expression. Genes & Development. 29: 1696-706. PMID 26251528 DOI: 10.1101/Gad.267286.115  1
2015 Pfister NT, Fomin V, Regunath K, Zhou JY, Zhou W, Silwal-Pandit L, Freed-Pastor WA, Laptenko O, Neo SP, Bargonetti J, Hoque M, Tian B, Gunaratne J, Engebraaten O, Manley JL, et al. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes & Development. 29: 1298-315. PMID 26080815 DOI: 10.1101/Gad.263202.115  0.96
2015 Drisaldi B, Colnaghi L, Fioriti L, Rao N, Myers C, Snyder AM, Metzger DJ, Tarasoff J, Konstantinov E, Fraser PE, Manley JL, Kandel ER. SUMOylation Is an Inhibitory Constraint that Regulates the Prion-like Aggregation and Activity of CPEB3. Cell Reports. 11: 1694-702. PMID 26074071 DOI: 10.1016/J.Celrep.2015.04.061  0.96
2015 Shi Y, Manley JL. The end of the message: multiple protein-RNA interactions define the mRNA polyadenylation site. Genes & Development. 29: 889-97. PMID 25934501 DOI: 10.1101/Gad.261974.115  0.48
2015 Li W, You B, Hoque M, Zheng D, Luo W, Ji Z, Park JY, Gunderson SI, Kalsotra A, Manley JL, Tian B. Systematic profiling of poly(A)+ transcripts modulated by core 3' end processing and splicing factors reveals regulatory rules of alternative cleavage and polyadenylation. Plos Genetics. 11: e1005166. PMID 25906188 DOI: 10.1371/Journal.Pgen.1005166  1
2015 Manley JL. A journey to the end of the message. Rna (New York, N.Y.). 21: 538-40. PMID 25780128 DOI: 10.1261/Rna.050724.115  1
2015 Ng CH, Akhter A, Yurko N, Burgener JM, Rosonina E, Manley JL. Sumoylation controls the timing of Tup1-mediated transcriptional deactivation. Nature Communications. 6: 6610. PMID 25766875 DOI: 10.1038/Ncomms7610  1
2015 Shi Y, Manley JL. The end of the message: Multiple protein–RNA interactions define the mRNA polyadenylation site Genes and Development. 29: 889-897.  1
2014 Lazarev D, Miller RL, Dimango E, Fu XD, Li HR, Logan CJ, Manley JL. cFLIP expression is altered in severe corticosteroid-resistant asthma. Genomics Data. 2: 99-104. PMID 26484081 DOI: 10.1016/J.Gdata.2014.05.003  0.36
2014 Di Giammartino DC, Li W, Ogami K, Yashinskie JJ, Hoque M, Tian B, Manley JL. RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs. Genes & Development. 28: 2248-60. PMID 25319826 DOI: 10.1101/Gad.245787.114  1
2014 Chan SL, Huppertz I, Yao C, Weng L, Moresco JJ, Yates JR, Ule J, Manley JL, Shi Y. CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing. Genes & Development. 28: 2370-80. PMID 25301780 DOI: 10.1101/Gad.250993.114  0.48
2014 Di Giammartino DC, Manley JL. New links between mRNA polyadenylation and diverse nuclear pathways. Molecules and Cells. 37: 644-9. PMID 25081038 DOI: 10.14348/Molcells.2014.0177  0.96
2014 Rosonina E, Yurko N, Li W, Hoque M, Tian B, Manley JL. Threonine-4 of the budding yeast RNAP II CTD couples transcription with Htz1-mediated chromatin remodeling. Proceedings of the National Academy of Sciences of the United States of America. 111: 11924-31. PMID 25071213 DOI: 10.1073/Pnas.1412802111  1
2014 Hsin JP, Li W, Hoque M, Tian B, Manley JL. RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells. Elife. 3: e02112. PMID 24842995 DOI: 10.7554/Elife.02112  1
2014 Hsin JP, Xiang K, Manley JL. Function and control of RNA polymerase II C-terminal domain phosphorylation in vertebrate transcription and RNA processing. Molecular and Cellular Biology. 34: 2488-98. PMID 24752900 DOI: 10.1128/Mcb.00181-14  1
2014 Xiang K, Tong L, Manley JL. Delineating the structural blueprint of the pre-mRNA 3'-end processing machinery. Molecular and Cellular Biology. 34: 1894-910. PMID 24591651 DOI: 10.1128/Mcb.00084-14  1
2014 Nagaike T, Manley JL. In vitro analysis of transcriptional activators and polyadenylation. Methods in Molecular Biology (Clifton, N.J.). 1125: 65-74. PMID 24590780 DOI: 10.1007/978-1-62703-971-0_6  0.32
2014 Morales JC, Richard P, Rommel A, Fattah FJ, Motea EA, Patidar PL, Xiao L, Leskov K, Wu SY, Hittelman WN, Chiang CM, Manley JL, Boothman DA. Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair. Nucleic Acids Research. 42: 4996-5006. PMID 24589584 DOI: 10.1093/Nar/Gku160  1
2014 Zhou X, Wu W, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H, Feng Y. Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation. Nucleic Acids Research. 42: 4019-30. PMID 24442672 DOI: 10.1093/nar/gkt1387  1
2014 Lazarev D, Miller RL, Dimango E, Fu XD, Li HR, Logan CJ, Manley JL. CFLIP expression is altered in severe corticosteroid-resistant asthma Genomics Data. 2: 99-104. DOI: 10.1016/j.gdata.2014.05.003  1
2013 Zhang J, Manley JL. Misregulation of pre-mRNA alternative splicing in cancer. Cancer Discovery. 3: 1228-37. PMID 24145039 DOI: 10.1158/2159-8290.Cd-13-0253  1
2013 Richard P, Feng S, Manley JL. A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. Genes & Development. 27: 2227-32. PMID 24105744 DOI: 10.1101/Gad.224923.113  1
2013 Richard P, Manley JL. How bidirectional becomes unidirectional. Nature Structural & Molecular Biology. 20: 1022-4. PMID 24008561 DOI: 10.1038/Nsmb.2657  1
2013 Vi SL, Trost G, Lange P, Czesnick H, Rao N, Lieber D, Laux T, Gray WM, Manley JL, Groth D, Kappel C, Lenhard M. Target specificity among canonical nuclear poly(A) polymerases in plants modulates organ growth and pathogen response. Proceedings of the National Academy of Sciences of the United States of America. 110: 13994-9. PMID 23918356 DOI: 10.1073/Pnas.1303967110  1
2013 Li H, Wang Z, Zhou X, Cheng Y, Xie Z, Manley JL, Feng Y. Far upstream element-binding protein 1 and RNA secondary structure both mediate second-step splicing repression. Proceedings of the National Academy of Sciences of the United States of America. 110: E2687-95. PMID 23818605 DOI: 10.1073/Pnas.1310607110  1
2013 Tian B, Manley JL. Alternative cleavage and polyadenylation: the long and short of it. Trends in Biochemical Sciences. 38: 312-20. PMID 23632313 DOI: 10.1016/J.Tibs.2013.03.005  1
2013 Di Giammartino DC, Shi Y, Manley JL. PARP1 represses PAP and inhibits polyadenylation during heat shock. Molecular Cell. 49: 7-17. PMID 23219533 DOI: 10.1016/J.Molcel.2012.11.005  1
2013 Zhang J, Neupane R, Canoll P, Lieu Y, Mukherjee S, Rabadan R, Raza A, Manley JL. Abstract IA6: Misregulation of pre-mRNA splicing in cancer Cancer Research. 73. DOI: 10.1158/1538-7445.Fbcr13-Ia6  0.56
2012 Biderman L, Manley JL, Prives C. Mdm2 and MdmX as Regulators of Gene Expression. Genes & Cancer. 3: 264-73. PMID 23150759 DOI: 10.1177/1947601912455331  1
2012 Xiang K, Manley JL, Tong L. An unexpected binding mode for a Pol II CTD peptide phosphorylated at Ser7 in the active site of the CTD phosphatase Ssu72. Genes & Development. 26: 2265-70. PMID 23070812 DOI: 10.1101/Gad.198853.112  1
2012 Hsin JP, Manley JL. The RNA polymerase II CTD coordinates transcription and RNA processing. Genes & Development. 26: 2119-37. PMID 23028141 DOI: 10.1101/Gad.200303.112  1
2012 Tan AY, Manley JL. TLS/FUS: a protein in cancer and ALS. Cell Cycle (Georgetown, Tex.). 11: 3349-50. PMID 22918236 DOI: 10.4161/Cc.21875  1
2012 Xiang K, Manley JL, Tong L. The yeast regulator of transcription protein Rtr1 lacks an active site and phosphatase activity. Nature Communications. 3: 946. PMID 22781759 DOI: 10.1038/Ncomms1947  1
2012 Tan AY, Riley TR, Coady T, Bussemaker HJ, Manley JL. TLS/FUS (translocated in liposarcoma/fused in sarcoma) regulates target gene transcription via single-stranded DNA response elements. Proceedings of the National Academy of Sciences of the United States of America. 109: 6030-5. PMID 22460799 DOI: 10.1073/Pnas.1203028109  1
2012 Rosonina E, Duncan SM, Manley JL. Sumoylation of transcription factor Gcn4 facilitates its Srb10-mediated clearance from promoters in yeast. Genes & Development. 26: 350-5. PMID 22345516 DOI: 10.1101/Gad.184689.111  1
2012 Chen M, David CJ, Manley JL. Concentration-dependent control of pyruvate kinase M mutually exclusive splicing by hnRNP proteins. Nature Structural & Molecular Biology. 19: 346-54. PMID 22307054 DOI: 10.1038/Nsmb.2219  1
2012 Biderman L, Poyurovsky MV, Assia Y, Manley JL, Prives C. MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress. Molecular and Cellular Biology. 32: 1214-25. PMID 22290440 DOI: 10.1128/Mcb.06150-11  1
2012 Kanehiro Y, Todo K, Negishi M, Fukuoka J, Gan W, Hikasa T, Kaga Y, Takemoto M, Magari M, Li X, Manley JL, Ohmori H, Kanayama N. Activation-induced cytidine deaminase (AID)-dependent somatic hypermutation requires a splice isoform of the serine/arginine-rich (SR) protein SRSF1. Proceedings of the National Academy of Sciences of the United States of America. 109: 1216-21. PMID 22232677 DOI: 10.1073/Pnas.1120368109  1
2011 David CJ, Manley JL. The RNA polymerase C-terminal domain: a new role in spliceosome assembly. Transcription. 2: 221-5. PMID 22231118 DOI: 10.4161/trns.2.5.17272  1
2011 Hsin JP, Sheth A, Manley JL. RNAP II CTD phosphorylated on threonine-4 is required for histone mRNA 3' end processing. Science (New York, N.Y.). 334: 683-6. PMID 22053051 DOI: 10.1126/Science.1206034  1
2011 Gan W, Guan Z, Liu J, Gui T, Shen K, Manley JL, Li X. R-loop-mediated genomic instability is caused by impairment of replication fork progression. Genes & Development. 25: 2041-56. PMID 21979917 DOI: 10.1101/Gad.17010011  1
2011 Nagaike T, Manley JL. Transcriptional activators enhance polyadenylation of mRNA precursors. Rna Biology. 8: 964-7. PMID 21941122 DOI: 10.4161/Rna.8.6.17210  1
2011 David CJ, Boyne AR, Millhouse SR, Manley JL. The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. Genes & Development. 25: 972-83. PMID 21536736 DOI: 10.1101/Gad.2038011  1
2011 Nagaike T, Logan C, Hotta I, Rozenblatt-Rosen O, Meyerson M, Manley JL. Transcriptional activators enhance polyadenylation of mRNA precursors. Molecular Cell. 41: 409-18. PMID 21329879 DOI: 10.1016/J.Molcel.2011.01.022  1
2011 Chang JH, Xiang S, Xiang K, Manley JL, Tong L. Structural and biochemical studies of the 5'→3' exoribonuclease Xrn1. Nature Structural & Molecular Biology. 18: 270-6. PMID 21297639 DOI: 10.1038/Nsmb.1984  1
2011 Bai Y, Srivastava SK, Chang JH, Manley JL, Tong L. Structural basis for dimerization and activity of human PAPD1, a noncanonical poly(A) polymerase. Molecular Cell. 41: 311-20. PMID 21292163 DOI: 10.1016/J.Molcel.2011.01.013  1
2011 Shi Y, Nishida K, Campigli Di Giammartino D, Manley JL. Heat shock-induced SRSF10 dephosphorylation displays thermotolerance mediated by Hsp27. Molecular and Cellular Biology. 31: 458-65. PMID 21135127 DOI: 10.1128/Mcb.01123-10  1
2011 David CJ, Manley JL. The RNA polymerase II C-terminal domain-A new role in spliceosome assembly Transcription. 2: 227-231.  1
2010 David CJ, Manley JL. Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged. Genes & Development. 24: 2343-64. PMID 21041405 DOI: 10.1101/Gad.1973010  1
2010 Chen M, Zhang J, Manley JL. Turning on a fuel switch of cancer: hnRNP proteins regulate alternative splicing of pyruvate kinase mRNA. Cancer Research. 70: 8977-80. PMID 20978194 DOI: 10.1158/0008-5472.Can-10-2513  1
2010 Xiang K, Nagaike T, Xiang S, Kilic T, Beh MM, Manley JL, Tong L. Crystal structure of the human symplekin-Ssu72-CTD phosphopeptide complex. Nature. 467: 729-33. PMID 20861839 DOI: 10.1038/Nature09391  1
2010 García A, Rosonina E, Manley JL, Calvo O. Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation. Molecular and Cellular Biology. 30: 5180-93. PMID 20823273 DOI: 10.1128/Mcb.00819-10  1
2010 Mutsuddi M, Mukherjee A, Shen B, Manley JL, Nambu JR. Drosophila Pelle phosphorylates Dichaete protein and influences its subcellular distribution in developing oocytes. The International Journal of Developmental Biology. 54: 1309-15. PMID 20563992 DOI: 10.1387/Ijdb.092991Mm  1
2010 Manley JL, Krainer AR. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes & Development. 24: 1073-4. PMID 20516191 DOI: 10.1101/Gad.1934910  1
2010 Chen M, David CJ, Manley JL. Tumor metabolism: hnRNP proteins get in on the act. Cell Cycle (Georgetown, Tex.). 9: 1863-4. PMID 20505328 DOI: 10.4161/Cc.9.10.11675  1
2010 Rosonina E, Duncan SM, Manley JL. SUMO functions in constitutive transcription and during activation of inducible genes in yeast. Genes & Development. 24: 1242-52. PMID 20504900 DOI: 10.1101/Gad.1917910  1
2010 Pedrotti S, Bielli P, Paronetto MP, Ciccosanti F, Fimia GM, Stamm S, Manley JL, Sette C. The splicing regulator Sam68 binds to a novel exonic splicing silencer and functions in SMN2 alternative splicing in spinal muscular atrophy. The Embo Journal. 29: 1235-47. PMID 20186123 DOI: 10.1038/Emboj.2010.19  1
2010 Rosonina E, Manley JL. Alternative polyadenylation blooms. Developmental Cell. 18: 172-4. PMID 20159589 DOI: 10.1016/J.Devcel.2010.02.001  1
2010 David CJ, Chen M, Assanah M, Canoll P, Manley JL. HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature. 463: 364-8. PMID 20010808 DOI: 10.1038/Nature08697  1
2010 Tan AY, Manley JL. TLS inhibits RNA polymerase III transcription. Molecular and Cellular Biology. 30: 186-96. PMID 19841068 DOI: 10.1128/Mcb.00884-09  1
2010 Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochemical Pharmacology. 79: 669-77. PMID 19814999 DOI: 10.1016/J.Bcp.2009.09.028  1
2010 Li X, Manley JL. The role of alternative splicing during the cell cycle and programmed cell death Handbook of Cell Signaling, 2/E. 3: 2329-2333. DOI: 10.1016/B978-0-12-374145-5.00280-1  1
2009 Vethantham V, Manley JL. In vitro sumoylation of recombinant proteins and subsequent purification for use in enzymatic assays. Cold Spring Harbor Protocols. 2009: pdb.prot5121. PMID 20147016 DOI: 10.1101/Pdb.Prot5121  1
2009 Tan AY, Manley JL. The TET family of proteins: functions and roles in disease. Journal of Molecular Cell Biology. 1: 82-92. PMID 19783543 DOI: 10.1093/Jmcb/Mjp025  1
2009 Chen M, Manley JL. Mechanisms of alternative splicing regulation: insights from molecular and genomics approaches. Nature Reviews. Molecular Cell Biology. 10: 741-54. PMID 19773805 DOI: 10.1038/Nrm2777  1
2009 Beckerman R, Donner AJ, Mattia M, Peart MJ, Manley JL, Espinosa JM, Prives C. A role for Chk1 in blocking transcriptional elongation of p21 RNA during the S-phase checkpoint. Genes & Development. 23: 1364-77. PMID 19487575 DOI: 10.1101/Gad.1795709  1
2009 Richard P, Manley JL. Transcription termination by nuclear RNA polymerases. Genes & Development. 23: 1247-69. PMID 19487567 DOI: 10.1101/Gad.1792809  1
2009 Wachtel C, Manley JL. Splicing of mRNA precursors: the role of RNAs and proteins in catalysis. Molecular Biosystems. 5: 311-6. PMID 19396366 DOI: 10.1039/B820828J  1
2009 Feng Y, Valley MT, Lazar J, Yang AL, Bronson RT, Firestein S, Coetzee WA, Manley JL. SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Developmental Cell. 16: 528-38. PMID 19386262 DOI: 10.1016/J.Devcel.2009.02.009  1
2009 Loomis RJ, Naoe Y, Parker JB, Savic V, Bozovsky MR, Macfarlan T, Manley JL, Chakravarti D. Chromatin binding of SRp20 and ASF/SF2 and dissociation from mitotic chromosomes is modulated by histone H3 serine 10 phosphorylation. Molecular Cell. 33: 450-61. PMID 19250906 DOI: 10.1016/J.Molcel.2009.02.003  1
2009 Shi Y, Di Giammartino DC, Taylor D, Sarkeshik A, Rice WJ, Yates JR, Frank J, Manley JL. Molecular architecture of the human pre-mRNA 3' processing complex. Molecular Cell. 33: 365-76. PMID 19217410 DOI: 10.1016/J.Molcel.2008.12.028  1
2009 Rosonina E, Willis IM, Manley JL. Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III. Molecular and Cellular Biology. 29: 2308-21. PMID 19204085 DOI: 10.1128/Mcb.01841-08  1
2009 Xiang S, Cooper-Morgan A, Jiao X, Kiledjian M, Manley JL, Tong L. Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1. Nature. 458: 784-8. PMID 19194460 DOI: 10.1038/Nature07731  1
2009 Rozenblatt-Rosen O, Nagaike T, Francis JM, Kaneko S, Glatt KA, Hughes CM, LaFramboise T, Manley JL, Meyerson M. The tumor suppressor Cdc73 functionally associates with CPSF and CstF 3' mRNA processing factors. Proceedings of the National Academy of Sciences of the United States of America. 106: 755-60. PMID 19136632 DOI: 10.1073/Pnas.0812023106  1
2009 Valadkhan S, Manley JL. The use of simple model systems to study spliceosomal catalysis. Rna (New York, N.Y.). 15: 4-7. PMID 19029305 DOI: 10.1261/Rna.1425809  1
2009 Vethantham V, Manley JL. Emerging roles for SUMO in mRNA processing and metabolism Sumo Regulation of Cellular Processes. 41-57. DOI: 10.1007/978-90-481-2649-1_3  1
2008 Feng Y, Chen M, Manley JL. Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator. Nature Structural & Molecular Biology. 15: 1040-8. PMID 18794844 DOI: 10.1038/Nsmb.1485  1
2008 Vethantham V, Rao N, Manley JL. Sumoylation regulates multiple aspects of mammalian poly(A) polymerase function. Genes & Development. 22: 499-511. PMID 18281463 DOI: 10.1101/Gad.1628208  1
2008 Mirkin N, Fonseca D, Mohammed S, Cevher MA, Manley JL, Kleiman FE. The 3' processing factor CstF functions in the DNA repair response. Nucleic Acids Research. 36: 1792-804. PMID 18252771 DOI: 10.1093/Nar/Gkn005  1
2008 David CJ, Manley JL. The search for alternative splicing regulators: new approaches offer a path to a splicing code. Genes & Development. 22: 279-85. PMID 18245441 DOI: 10.1101/Gad.1643108  1
2008 Bush SD, Richard P, Manley JL. Variations in intracellular levels of TATA binding protein can affect specific genes by different mechanisms. Molecular and Cellular Biology. 28: 83-92. PMID 17954564 DOI: 10.1128/Mcb.00809-07  1
2007 Sims RJ, Millhouse S, Chen CF, Lewis BA, Erdjument-Bromage H, Tempst P, Manley JL, Reinberg D. Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing. Molecular Cell. 28: 665-76. PMID 18042460 DOI: 10.1016/J.Molcel.2007.11.010  1
2007 Xu YX, Manley JL. Pin1 modulates RNA polymerase II activity during the transcription cycle. Genes & Development. 21: 2950-62. PMID 18006688 DOI: 10.1101/Gad.1592807  1
2007 Xu YX, Manley JL. New insights into mitotic chromosome condensation: a role for the prolyl isomerase Pin1. Cell Cycle (Georgetown, Tex.). 6: 2896-901. PMID 17993783 DOI: 10.4161/Cc.6.23.4977  1
2007 Kaneko S, Chu C, Shatkin AJ, Manley JL. Human capping enzyme promotes formation of transcriptional R loops in vitro. Proceedings of the National Academy of Sciences of the United States of America. 104: 17620-5. PMID 17978174 DOI: 10.1073/Pnas.0708866104  1
2007 Li X, Niu T, Manley JL. The RNA binding protein RNPS1 alleviates ASF/SF2 depletion-induced genomic instability. Rna (New York, N.Y.). 13: 2108-15. PMID 17959926 DOI: 10.1261/Rna.734407  1
2007 Valadkhan S, Mohammadi A, Wachtel C, Manley JL. Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing. Rna (New York, N.Y.). 13: 2300-11. PMID 17940139 DOI: 10.1261/Rna.626207  1
2007 Shi Y, Manley JL. A complex signaling pathway regulates SRp38 phosphorylation and pre-mRNA splicing in response to heat shock. Molecular Cell. 28: 79-90. PMID 17936706 DOI: 10.1016/J.Molcel.2007.08.028  1
2007 Vethantham V, Rao N, Manley JL. Sumoylation modulates the assembly and activity of the pre-mRNA 3' processing complex. Molecular and Cellular Biology. 27: 8848-58. PMID 17923699 DOI: 10.1128/Mcb.01186-07  1
2007 Kaneko S, Rozenblatt-Rosen O, Meyerson M, Manley JL. The multifunctional protein p54nrb/PSF recruits the exonuclease XRN2 to facilitate pre-mRNA 3' processing and transcription termination. Genes & Development. 21: 1779-89. PMID 17639083 DOI: 10.1101/Gad.1565207  1
2007 Lazarev D, Manley JL. Concurrent splicing and transcription are not sufficient to enhance splicing efficiency. Rna (New York, N.Y.). 13: 1546-57. PMID 17630325 DOI: 10.1261/Rna.595907  1
2007 Ali GS, Palusa SG, Golovkin M, Prasad J, Manley JL, Reddy AS. Regulation of plant developmental processes by a novel splicing factor. Plos One. 2: e471. PMID 17534421 DOI: 10.1371/Journal.Pone.0000471  1
2007 Xu YX, Manley JL. The prolyl isomerase Pin1 functions in mitotic chromosome condensation. Molecular Cell. 26: 287-300. PMID 17466629 DOI: 10.1016/J.Molcel.2007.03.020  1
2007 Bai Y, Auperin TC, Chou CY, Chang GG, Manley JL, Tong L. Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursors. Molecular Cell. 25: 863-75. PMID 17386263 DOI: 10.1016/J.Molcel.2007.01.034  1
2007 Kashima T, Rao N, Manley JL. An intronic element contributes to splicing repression in spinal muscular atrophy. Proceedings of the National Academy of Sciences of the United States of America. 104: 3426-31. PMID 17307868 DOI: 10.1073/Pnas.0700343104  1
2006 Bush S, Manley JL. Transcription and RNA processing factors play complex roles in DT40 cells. Sub-Cellular Biochemistry. 40: 207-23. PMID 17623907 DOI: 10.1007/978-1-4020-4896-8_12  1
2006 Mandel CR, Kaneko S, Zhang H, Gebauer D, Vethantham V, Manley JL, Tong L. Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease. Nature. 444: 953-6. PMID 17128255 DOI: 10.1038/Nature05363  1
2006 Shi Y, Reddy B, Manley JL. PP1/PP2A phosphatases are required for the second step of Pre-mRNA splicing and target specific snRNP proteins. Molecular Cell. 23: 819-29. PMID 16973434 DOI: 10.1016/J.Molcel.2006.07.022  1
2006 Li X, Manley JL. Cotranscriptional processes and their influence on genome stability. Genes & Development. 20: 1838-47. PMID 16847344 DOI: 10.1101/Gad.1438306  1
2006 Li X, Manley JL. Alternative splicing and control of apoptotic DNA fragmentation. Cell Cycle (Georgetown, Tex.). 5: 1286-8. PMID 16760667 DOI: 10.4161/Cc.5.12.2832  1
2006 Rosonina E, Kaneko S, Manley JL. Terminating the transcript: breaking up is hard to do. Genes & Development. 20: 1050-6. PMID 16651651 DOI: 10.1101/Gad.1431606  1
2006 Marin-Vinader L, Shin C, Onnekink C, Manley JL, Lubsen NH. Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock. Molecular Biology of the Cell. 17: 886-94. PMID 16339078 DOI: 10.1091/Mbc.E05-07-0596  1
2005 Li X, Manley JL. New talents for an old acquaintance: the SR protein splicing factor ASF/SF2 functions in the maintenance of genome stability. Cell Cycle (Georgetown, Tex.). 4: 1706-8. PMID 16294036 DOI: 10.4161/Cc.4.12.2210  1
2005 Li X, Wang J, Manley JL. Loss of splicing factor ASF/SF2 induces G2 cell cycle arrest and apoptosis, but inhibits internucleosomal DNA fragmentation. Genes & Development. 19: 2705-14. PMID 16260492 DOI: 10.1101/Gad.1359305  1
2005 Rosonina E, Manley JL. From transcription to mRNA: PAF provides a new path. Molecular Cell. 20: 167-8. PMID 16246718 DOI: 10.1016/J.Molcel.2005.10.004  1
2005 Kaneko S, Manley JL. The mammalian RNA polymerase II C-terminal domain interacts with RNA to suppress transcription-coupled 3' end formation. Molecular Cell. 20: 91-103. PMID 16209948 DOI: 10.1016/J.Molcel.2005.08.033  1
2005 Shin C, Kleiman FE, Manley JL. Multiple properties of the splicing repressor SRp38 distinguish it from typical SR proteins. Molecular and Cellular Biology. 25: 8334-43. PMID 16135820 DOI: 10.1128/Mcb.25.18.8334-8343.2005  1
2005 Li X, Manley JL. Inactivation of the SR protein splicing factor ASF/SF2 results in genomic instability. Cell. 122: 365-78. PMID 16096057 DOI: 10.1016/J.Cell.2005.06.008  1
2005 Kleiman FE, Wu-Baer F, Fonseca D, Kaneko S, Baer R, Manley JL. BRCA1/BARD1 inhibition of mRNA 3' processing involves targeted degradation of RNA polymerase II. Genes & Development. 19: 1227-37. PMID 15905410 DOI: 10.1101/Gad.1309505  1
2005 Calvo O, Manley JL. The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription. The Embo Journal. 24: 1009-20. PMID 15692559 DOI: 10.1038/Sj.Emboj.7600575  1
2005 Xu X, Yang D, Ding JH, Wang W, Chu PH, Dalton ND, Wang HY, Bermingham JR, Ye Z, Liu F, Rosenfeld MG, Manley JL, Ross J, Chen J, Xiao RP, et al. ASF/SF2-regulated CaMKIIdelta alternative splicing temporally reprograms excitation-contraction coupling in cardiac muscle. Cell. 120: 59-72. PMID 15652482 DOI: 10.1016/J.Cell.2004.11.036  1
2005 Millhouse S, Manley JL. The C-terminal domain of RNA polymerase II functions as a phosphorylation-dependent splicing activator in a heterologous protein. Molecular and Cellular Biology. 25: 533-44. PMID 15632056 DOI: 10.1128/Mcb.25.2.533-544.2005  1
2004 Barnard DC, Ryan K, Manley JL, Richter JD. Symplekin and xGLD-2 are required for CPEB-mediated cytoplasmic polyadenylation. Cell. 119: 641-51. PMID 15550246 DOI: 10.1016/J.Cell.2004.10.029  1
2004 Shin C, Manley JL. Cell signalling and the control of pre-mRNA splicing. Nature Reviews. Molecular Cell Biology. 5: 727-38. PMID 15340380 DOI: 10.1038/Nrm1467  1
2004 Ryan K, Calvo O, Manley JL. Evidence that polyadenylation factor CPSF-73 is the mRNA 3' processing endonuclease. Rna (New York, N.Y.). 10: 565-73. PMID 15037765 DOI: 10.1261/Rna.5214404  1
2004 Shin C, Feng Y, Manley JL. Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock. Nature. 427: 553-8. PMID 14765198 DOI: 10.1038/Nature02288  1
2004 Xu YX, Manley JL. Pinning down transcription: regulation of RNA polymerase II activity during the cell cycle. Cell Cycle (Georgetown, Tex.). 3: 432-5. PMID 14739776 DOI: 10.4161/Cc.3.4.769  1
2003 Xu YX, Hirose Y, Zhou XZ, Lu KP, Manley JL. Pin1 modulates the structure and function of human RNA polymerase II. Genes & Development. 17: 2765-76. PMID 14600023 DOI: 10.1101/Gad.1135503  1
2003 Poyurovsky MV, Jacq X, Ma C, Karni-Schmidt O, Parker PJ, Chalfie M, Manley JL, Prives C. Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization. Molecular Cell. 12: 875-87. PMID 14580339 DOI: 10.1016/S1097-2765(03)00400-3  1
2003 Chen Z, Manley JL. Core promoter elements and TAFs contribute to the diversity of transcriptional activation in vertebrates. Molecular and Cellular Biology. 23: 7350-62. PMID 14517303 DOI: 10.1128/Mcb.23.20.7350-7362.2003  1
2003 Chen Z, Manley JL. In vivo functional analysis of the histone 3-like TAF9 and a TAF9-related factor, TAF9L. The Journal of Biological Chemistry. 278: 35172-83. PMID 12837753 DOI: 10.1074/Jbc.M304241200  1
2003 Kashima T, Manley JL. A negative element in SMN2 exon 7 inhibits splicing in spinal muscular atrophy. Nature Genetics. 34: 460-3. PMID 12833158 DOI: 10.1038/Ng1207  1
2003 Valadkhan S, Manley JL. Characterization of the catalytic activity of U2 and U6 snRNAs. Rna (New York, N.Y.). 9: 892-904. PMID 12810922 DOI: 10.1261/Rna.5440303  1
2003 Calvo O, Manley JL. Strange bedfellows: polyadenylation factors at the promoter. Genes & Development. 17: 1321-7. PMID 12782649 DOI: 10.1101/Gad.1093603  1
2003 Prasad J, Manley JL. Regulation and substrate specificity of the SR protein kinase Clk/Sty. Molecular and Cellular Biology. 23: 4139-49. PMID 12773558 DOI: 10.1128/Mcb.23.12.4139-4149.2003  1
2003 Schwerk C, Prasad J, Degenhardt K, Erdjument-Bromage H, White E, Tempst P, Kidd VJ, Manley JL, Lahti JM, Reinberg D. ASAP, a novel protein complex involved in RNA processing and apoptosis. Molecular and Cellular Biology. 23: 2981-90. PMID 12665594 DOI: 10.1128/Mcb.23.8.2981-2990.2003  1
2003 Portal D, Lobo GS, Kadener S, Prasad J, Espinosa JM, Pereira CA, Tang Z, Lin RJ, Manley JL, Kornblihtt AR, Flawiá MM, Torres HN. Trypanosoma cruzi TcSRPK, the first protozoan member of the SRPK family, is biochemically and functionally conserved with metazoan SR protein-specific kinases. Molecular and Biochemical Parasitology. 127: 9-21. PMID 12615332 DOI: 10.1016/S0166-6851(02)00299-2  1
2003 Shin C, Manley JL. Role of Alternative Splicing During the Cell Cycle and Programmed Cell Death Handbook of Cell Signaling. 3: 331-334. DOI: 10.1016/B978-012124546-7/50682-3  0.96
2002 Shin C, Manley JL. The SR protein SRp38 represses splicing in M phase cells. Cell. 111: 407-17. PMID 12419250 DOI: 10.1016/S0092-8674(02)01038-3  1
2002 Manley JL. Nuclear coupling: RNA processing reaches back to transcription. Nature Structural Biology. 9: 790-1. PMID 12402032 DOI: 10.1038/Nsb1102-790  1
2002 Valadkhan S, Manley JL. Intrinsic metal binding by a spliceosomal RNA. Nature Structural Biology. 9: 498-9. PMID 12080335 DOI: 10.1038/Nsb0702-498  1
2002 Shen B, Manley JL. Pelle kinase is activated by autophosphorylation during Toll signaling in Drosophila. Development (Cambridge, England). 129: 1925-33. PMID 11934858  1
2002 Chen A, Kleiman FE, Manley JL, Ouchi T, Pan ZQ. Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase. The Journal of Biological Chemistry. 277: 22085-92. PMID 11927591 DOI: 10.1074/Jbc.M201252200  1
2002 Lemaire R, Prasad J, Kashima T, Gustafson J, Manley JL, Lafyatis R. Stability of a PKCI-1-related mRNA is controlled by the splicing factor ASF/SF2: a novel function for SR proteins. Genes & Development. 16: 594-607. PMID 11877379 DOI: 10.1101/Gad.939502  1
2002 Ryan K, Murthy KG, Kaneko S, Manley JL. Requirements of the RNA polymerase II C-terminal domain for reconstituting pre-mRNA 3' cleavage. Molecular and Cellular Biology. 22: 1684-92. PMID 11865048 DOI: 10.1128/Mcb.22.6.1684-1692.2002  1
2002 Valadkhan S, Manley JL. Erratum: Intrinsic metal binding by a spliceosomal RNA Nature Structural & Molecular Biology. 9: 711-711. DOI: 10.1038/Nsb0902-711B  1
2001 Luo C, Shen B, Manley JL, Zheng L. Tehao functions in the Toll pathway in Drosophila melanogaster: possible roles in development and innate immunity. Insect Molecular Biology. 10: 457-64. PMID 11881810 DOI: 10.1046/j.0962-1075.2001.00284.x  1
2001 Prives C, Manley JL. Why is p53 acetylated? Cell. 107: 815-8. PMID 11779456 DOI: 10.1016/S0092-8674(01)00619-5  1
2001 Valadkhan S, Manley JL. Splicing-related catalysis by protein-free snRNAs. Nature. 413: 701-7. PMID 11607023 DOI: 10.1038/35099500  1
2001 Topalian SL, Kaneko S, Gonzales MI, Bond GL, Ward Y, Manley JL. Identification and functional characterization of neo-poly(A) polymerase, an RNA processing enzyme overexpressed in human tumors. Molecular and Cellular Biology. 21: 5614-23. PMID 11463842 DOI: 10.1128/Mcb.21.16.5614-5623.2001  1
2001 Shen B, Liu H, Skolnik EY, Manley JL. Physical and functional interactions between Drosophila TRAF2 and Pelle kinase contribute to Dorsal activation. Proceedings of the National Academy of Sciences of the United States of America. 98: 8596-601. PMID 11447260 DOI: 10.1073/Pnas.141235698  1
2001 Calvo O, Manley JL. Evolutionarily conserved interaction between CstF-64 and PC4 links transcription, polyadenylation, and termination. Molecular Cell. 7: 1013-23. PMID 11389848 DOI: 10.1016/S1097-2765(01)00236-2  1
2001 Um M, Yamauchi J, Kato S, Manley JL. Heterozygous disruption of the TATA-binding protein gene in DT40 cells causes reduced cdc25B phosphatase expression and delayed mitosis. Molecular and Cellular Biology. 21: 2435-48. PMID 11259592 DOI: 10.1128/Mcb.21.7.2435-2448.2001  1
2001 Kleiman FE, Manley JL. The BARD1-CstF-50 interaction links mRNA 3' end formation to DNA damage and tumor suppression. Cell. 104: 743-53. PMID 11257228 DOI: 10.1016/S0092-8674(01)00270-7  1
2000 Um M, Manley JL. The Drosophila TATA binding protein contains a strong but masked activation domain. Gene Expression. 9: 123-32. PMID 11243409  1
2000 Mendez R, Murthy KG, Ryan K, Manley JL, Richter JD. Phosphorylation of CPEB by Eg2 mediates the recruitment of CPSF into an active cytoplasmic polyadenylation complex. Molecular Cell. 6: 1253-9. PMID 11106762 DOI: 10.1016/S1097-2765(00)00121-0  1
2000 Xu Y, Tao X, Shen B, Horng T, Medzhitov R, Manley JL, Tong L. Structural basis for signal transduction by the Toll/interleukin-1 receptor domains. Nature. 408: 111-5. PMID 11081518 DOI: 10.1038/35040600  1
2000 Shatkin AJ, Manley JL. The ends of the affair: capping and polyadenylation. Nature Structural Biology. 7: 838-42. PMID 11017188 DOI: 10.1038/79583  1
2000 Bond GL, Prives C, Manley JL. Poly(A) polymerase phosphorylation is dependent on novel interactions with cyclins. Molecular and Cellular Biology. 20: 5310-20. PMID 10866687 DOI: 10.1128/Mcb.20.14.5310-5320.2000  1
2000 Chen Z, Manley JL. Robust mRNA transcription in chicken DT40 cells depleted of TAF(II)31 suggests both functional degeneracy and evolutionary divergence. Molecular and Cellular Biology. 20: 5064-76. PMID 10866663 DOI: 10.1128/Mcb.20.14.5064-5076.2000  1
2000 Hirose Y, Manley JL. RNA polymerase II and the integration of nuclear events. Genes & Development. 14: 1415-29. PMID 10859161 DOI: 10.1101/Gad.14.12.1415  1
2000 Koffa MD, Graham SV, Takagaki Y, Manley JL, Clements JB. The human papillomavirus type 16 negative regulatory RNA element interacts with three proteins that act at different posttranscriptional levels. Proceedings of the National Academy of Sciences of the United States of America. 97: 4677-82. PMID 10781073 DOI: 10.1073/Pnas.070049097  1
2000 Valadkhan S, Manley JL. A tertiary interaction detected in a human U2-U6 snRNA complex assembled in vitro resembles a genetically proven interaction in yeast. Rna (New York, N.Y.). 6: 206-19. PMID 10688360 DOI: 10.1017/S1355838200992197  1
2000 Takagaki Y, Manley JL. Complex protein interactions within the human polyadenylation machinery identify a novel component. Molecular and Cellular Biology. 20: 1515-25. PMID 10669729 DOI: 10.1128/Mcb.20.5.1515-1525.2000  1
2000 Hatton LS, Eloranta JJ, Figueiredo LM, Takagaki Y, Manley JL, O'Hare K. The Drosophila homologue of the 64 kDa subunit of cleavage stimulation factor interacts with the 77 kDa subunit encoded by the suppressor of forked gene. Nucleic Acids Research. 28: 520-6. PMID 10606651 DOI: 10.1093/Nar/28.2.520  1
1999 Prasad J, Colwill K, Pawson T, Manley JL. The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Molecular and Cellular Biology. 19: 6991-7000. PMID 10490636 DOI: 10.1128/Mcb.19.10.6991  1
1999 Kleiman FE, Manley JL. Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50. Science (New York, N.Y.). 285: 1576-9. PMID 10477523 DOI: 10.1126/Science.285.5433.1576  1
1999 Tacke R, Manley JL. Determinants of SR protein specificity. Current Opinion in Cell Biology. 11: 358-62. PMID 10395560 DOI: 10.1016/S0955-0674(99)80050-7  1
1999 Hirose Y, Tacke R, Manley JL. Phosphorylated RNA polymerase II stimulates pre-mRNA splicing. Genes & Development. 13: 1234-9. PMID 10346811 DOI: 10.1101/Gad.13.10.1234  1
1999 Li C, Manley JL. Allosteric regulation of even-skipped repression activity by phosphorylation. Molecular Cell. 3: 77-86. PMID 10024881 DOI: 10.1016/S1097-2765(00)80176-8  1
1999 Tacke R, Manley JL. Functions of SR and Tra2 proteins in pre-mRNA splicing regulation. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 220: 59-63. PMID 9933499 DOI: 10.1046/J.1525-1373.1999.D01-10.X  1
1998 Takagaki Y, Manley JL. Levels of polyadenylation factor CstF-64 control IgM heavy chain mRNA accumulation and other events associated with B cell differentiation. Molecular Cell. 2: 761-71. PMID 9885564 DOI: 10.1016/S1097-2765(00)80291-9  1
1998 Shen B, Manley JL. Phosphorylation modulates direct interactions between the Toll receptor, Pelle kinase and Tube. Development (Cambridge, England). 125: 4719-28. PMID 9806920  1
1998 Xiao SH, Manley JL. Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. The Embo Journal. 17: 6359-67. PMID 9799243 DOI: 10.1093/Emboj/17.21.6359  1
1998 Hirose Y, Manley JL. RNA polymerase II is an essential mRNA polyadenylation factor. Nature. 395: 93-6. PMID 9738505 DOI: 10.1038/25786  1
1998 Moreira A, Takagaki Y, Brackenridge S, Wollerton M, Manley JL, Proudfoot NJ. The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms. Genes & Development. 12: 2522-34. PMID 9716405 DOI: 10.1101/Gad.12.16.2522  1
1998 Zhao W, Manley JL. Deregulation of poly(A) polymerase interferes with cell growth. Molecular and Cellular Biology. 18: 5010-20. PMID 9710585 DOI: 10.1128/Mcb.18.9.5010  1
1998 Wang J, Xiao SH, Manley JL. Genetic analysis of the SR protein ASF/SF2: interchangeability of RS domains and negative control of splicing. Genes & Development. 12: 2222-33. PMID 9679066 DOI: 10.1101/Gad.12.14.2222  1
1998 Li C, Manley JL. Even-skipped represses transcription by binding TATA binding protein and blocking the TFIID-TATA box interaction. Molecular and Cellular Biology. 18: 3771-81. PMID 9632760 DOI: 10.1128/Mcb.18.7.3771  1
1998 Sun JS, Valadkhan S, Manley JL. A UV-crosslinkable interaction in human U6 snRNA. Rna (New York, N.Y.). 4: 489-97. PMID 9582092 DOI: 10.1017/S1355838298980141  1
1998 Tacke R, Tohyama M, Ogawa S, Manley JL. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell. 93: 139-48. PMID 9546399 DOI: 10.1016/S0092-8674(00)81153-8  1
1998 Jayaraman L, Moorthy NC, Murthy KG, Manley JL, Bustin M, Prives C. High mobility group protein-1 (HMG-1) is a unique activator of p53. Genes & Development. 12: 462-72. PMID 9472015 DOI: 10.1101/Gad.12.4.462  1
1998 Colgan DF, Murthy KG, Zhao W, Prives C, Manley JL. Inhibition of poly(A) polymerase requires p34cdc2/cyclin B phosphorylation of multiple consensus and non-consensus sites. The Embo Journal. 17: 1053-62. PMID 9463383 DOI: 10.1093/Emboj/17.4.1053  1
1997 Hirose Y, Manley JL. Creatine phosphate, not ATP, is required for 3' end cleavage of mammalian pre-mRNA in vitro. The Journal of Biological Chemistry. 272: 29636-42. PMID 9368030 DOI: 10.1074/Jbc.272.47.29636  1
1997 Colgan DF, Manley JL. Mechanism and regulation of mRNA polyadenylation. Genes & Development. 11: 2755-66. PMID 9353246 DOI: 10.1101/Gad.11.21.2755  1
1997 Takagaki Y, Manley JL. RNA recognition by the human polyadenylation factor CstF. Molecular and Cellular Biology. 17: 3907-14. PMID 9199325 DOI: 10.1128/Mcb.17.7.3907  1
1997 Sun JS, Manley JL. The human U6 snRNA intramolecular helix: structural constraints and lack of sequence specificity. Rna (New York, N.Y.). 3: 514-26. PMID 9149232  1
1997 Wang J, Manley JL. Regulation of pre-mRNA splicing in metazoa. Current Opinion in Genetics & Development. 7: 205-11. PMID 9115432 DOI: 10.1016/S0959-437X(97)80130-X  1
1997 Tacke R, Chen Y, Manley JL. Sequence-specific RNA binding by an SR protein requires RS domain phosphorylation: creation of an SRp40-specific splicing enhancer. Proceedings of the National Academy of Sciences of the United States of America. 94: 1148-53. PMID 9037021 DOI: 10.1073/Pnas.94.4.1148  1
1997 Xiao SH, Manley JL. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes & Development. 11: 334-44. PMID 9030686 DOI: 10.1101/Gad.11.3.334  1
1996 Manley JL, Takagaki Y. The end of the message--another link between yeast and mammals. Science (New York, N.Y.). 274: 1481-2. PMID 8966619 DOI: 10.1126/Science.274.5292.1481  1
1996 Takagaki Y, Seipelt RL, Peterson ML, Manley JL. The polyadenylation factor CstF-64 regulates alternative processing of IgM heavy chain pre-mRNA during B cell differentiation. Cell. 87: 941-52. PMID 8945520 DOI: 10.1016/S0092-8674(00)82000-0  1
1996 Farmer G, Friedlander P, Colgan J, Manley JL, Prives C. Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein. Nucleic Acids Research. 24: 4281-8. PMID 8932384 DOI: 10.1093/Nar/24.21.4281  1
1996 Colgan DF, Murthy KG, Prives C, Manley JL. Cell-cycle related regulation of poly(A) polymerase by phosphorylation. Nature. 384: 282-5. PMID 8918882 DOI: 10.1038/384282A0  1
1996 Wang J, Takagaki Y, Manley JL. Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability. Genes & Development. 10: 2588-99. PMID 8895660 DOI: 10.1101/GAD.10.20.2588  1
1996 Norris JL, Manley JL. Functional interactions between the pelle kinase, Toll receptor, and tube suggest a mechanism for activation of dorsal. Genes & Development. 10: 862-72. PMID 8846922 DOI: 10.1101/Gad.10.7.862  1
1996 Farmer G, Colgan J, Nakatani Y, Manley JL, Prives C. Functional interaction between p53, the TATA-binding protein (TBP), andTBP-associated factors in vivo. Molecular and Cellular Biology. 16: 4295-304. PMID 8754830 DOI: 10.1128/Mcb.16.8.4295  1
1996 Manley JL, Um M, Li C, Ashali H. Mechanisms of transcriptional activation and repression can both involve TFIID. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 517-26. PMID 8735274 DOI: 10.1098/Rstb.1996.0050  1
1996 Manley JL, Tacke R. SR proteins and splicing control. Genes & Development. 10: 1569-79. PMID 8682289 DOI: 10.1101/Gad.10.13.1569  1
1996 Zhao W, Manley JL. Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Molecular and Cellular Biology. 16: 2378-86. PMID 8628305 DOI: 10.1128/Mcb.16.5.2378  1
1996 Colwill K, Pawson T, Andrews B, Prasad J, Manley JL, Bell JC, Duncan PI. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. The Embo Journal. 15: 265-75. PMID 8617202 DOI: 10.1002/J.1460-2075.1996.Tb00357.X  1
1996 Lutz CS, Murthy KG, Schek N, O'Connor JP, Manley JL, Alwine JC. Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro. Genes & Development. 10: 325-37. PMID 8595883 DOI: 10.1101/Gad.10.3.325  1
1995 Bermingham JR, Arden KC, Naumova AK, Sapienza C, Viars CS, Fu XD, Khotz J, Manley JL, Rosenfeld MG. Chromosomal localization of mouse and human genes encoding the splicing factors ASF/SF2 (SFRS1) and SC-35 (SFRS2). Genomics. 29: 70-9. PMID 8530103 DOI: 10.1006/Geno.1995.1216  1
1995 Sun JS, Manley JL. A novel U2-U6 snRNA structure is necessary for mammalian mRNA splicing. Genes & Development. 9: 843-54. PMID 7705661  0.6
1995 Jamison SF, Pasman Z, Wang J, Will C, Lührmann R, Manley JL, Garcia-Blanco MA. U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements. Nucleic Acids Research. 23: 3260-7. PMID 7667103 DOI: 10.1093/Nar/23.16.3260  1
1995 Um M, Li C, Manley JL. The transcriptional repressor even-skipped interacts directly with TATA-binding protein. Molecular and Cellular Biology. 15: 5007-16. PMID 7651419 DOI: 10.1128/Mcb.15.9.5007  1
1995 Wang J, Manley JL. Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways. Rna (New York, N.Y.). 1: 335-46. PMID 7489505  1
1994 Kohtz JD, Jamison SF, Will CL, Zuo P, Lührmann R, Garcia-Blanco MA, Manley JL. Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors. Nature. 368: 119-24. PMID 8139654 DOI: 10.1038/368119A0  1
1994 Manley JL, Proudfoot NJ. RNA 3' ends: formation and function--meeting review. Genes & Development. 8: 259-64. PMID 7906236  1
1994 Zuo P, Manley JL. The human splicing factor ASF/SF2 can specifically recognize pre-mRNA 5' splice sites. Proceedings of the National Academy of Sciences of the United States of America. 91: 3363-7. PMID 7512732 DOI: 10.1073/Pnas.91.8.3363  1
1993 Zuo P, Manley JL. Functional domains of the human splicing factor ASF/SF2. The Embo Journal. 12: 4727-37. PMID 8223481 DOI: 10.1002/J.1460-2075.1993.Tb06161.X  1
1992 Takagaki Y, MacDonald CC, Shenk T, Manley JL. The human 64-kDa polyadenylylation factor contains a ribonucleoprotein-type RNA binding domain and unusual auxiliary motifs. Proceedings of the National Academy of Sciences of the United States of America. 89: 1403-7. PMID 1741396 DOI: 10.1073/Pnas.89.4.1403  1
1992 Kim YJ, Zuo P, Manley JL, Baker BS. The Drosophila RNA-binding protein RBP1 is localized to transcriptionally active sites of chromosomes and shows a functional similarity to human splicing factor ASF/SF2. Genes & Development. 6: 2569-79. PMID 1340470 DOI: 10.1101/Gad.6.12B.2569  1
1991 Ge H, Zuo P, Manley JL. Primary structure of the human splicing factor ASF reveals similarities with Drosophila regulators. Cell. 66: 373-82. PMID 1855257 DOI: 10.1016/0092-8674(91)90626-A  1
1991 Zuo P, Stanojević D, Colgan J, Han K, Levine M, Manley JL. Activation and repression of transcription by the gap proteins hunchback and Krüppel in cultured Drosophila cells. Genes & Development. 5: 254-64. PMID 1671661 DOI: 10.1101/Gad.5.2.254  1
1991 Han YM, Dahlberg J, Lund E, Manley JL, Prives C. SV40 T-antigen-binding sites within the 5'-flanking regions of human U1 and U2 genes. Gene. 109: 219-31. PMID 1662655 DOI: 10.1016/0378-1119(91)90612-F  1
1990 Wilusz J, Shenk T, Takagaki Y, Manley JL. A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates. Molecular and Cellular Biology. 10: 1244-8. PMID 2304466 DOI: 10.1128/Mcb.10.3.1244  1
1990 Harper JE, Miceli SM, Roberts RJ, Manley JL. Sequence specificity of the human mRNA N6-adenosine methylase in vitro. Nucleic Acids Research. 18: 5735-41. PMID 2216767 DOI: 10.1093/Nar/18.19.5735  1
1990 Ge H, Manley JL. A protein factor, ASF, controls cell-specific alternative splicing of SV40 early pre-mRNA in vitro. Cell. 62: 25-34. PMID 2163768 DOI: 10.1016/0092-8674(90)90236-8  1
1990 Ge H, Noble J, Colgan J, Manley JL. Polyoma virus small tumor antigen pre-mRNA splicing requires cooperation between two 3' splice sites. Proceedings of the National Academy of Sciences of the United States of America. 87: 3338-42. PMID 2159146 DOI: 10.1073/Pnas.87.9.3338  0.76
1990 Takagaki Y, Manley JL, MacDonald CC, Wilusz J, Shenk T. A multisubunit factor, CstF, is required for polyadenylation of mammalian pre-mRNAs. Genes & Development. 4: 2112-20. PMID 1980119 DOI: 10.1101/Gad.4.12A.2112  1
1989 Connelly S, Manley JL. A CCAAT box sequence in the adenovirus major late promoter functions as part of an RNA polymerase II termination signal. Cell. 57: 561-71. PMID 2720783 DOI: 10.1016/0092-8674(89)90126-8  1
1989 Manley JL, Proudfoot NJ, Platt T. RNA 3'-end formation. Genes & Development. 3: 2218-22. PMID 2628168 DOI: 10.1101/Gad.3.12B.2218  1
1989 Connelly S, Manley JL. RNA polymerase II transcription termination is mediated specifically by protein binding to a CCAAT box sequence. Molecular and Cellular Biology. 9: 5254-9. PMID 2601722 DOI: 10.1128/Mcb.9.11.5254  1
1989 Rushlow CA, Han K, Manley JL, Levine M. The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell. 59: 1165-77. PMID 2598265 DOI: 10.1016/0092-8674(89)90772-1  1
1989 Ryner LC, Takagaki Y, Manley JL. Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectly. Molecular and Cellular Biology. 9: 1759-71. PMID 2566911 DOI: 10.1128/Mcb.9.4.1759  1
1989 Han K, Levine MS, Manley JL. Synergistic activation and repression of transcription by Drosophila homeobox proteins. Cell. 56: 573-83. PMID 2563673 DOI: 10.1016/0092-8674(89)90580-1  1
1989 Wu J, Manley JL. Mammalian pre-mRNA branch site selection by U2 snRNP involves base pairing. Genes & Development. 3: 1553-61. PMID 2558966 DOI: 10.1101/Gad.3.10.1553  1
1989 Takagaki Y, Ryner LC, Manley JL. Four factors are required for 3'-end cleavage of pre-mRNAs. Genes & Development. 3: 1711-24. PMID 2558045 DOI: 10.1101/Gad.3.11.1711  1
1989 Ryner LC, Takagaki Y, Manley JL. Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formation. Molecular and Cellular Biology. 9: 4229-38. PMID 2555686 DOI: 10.1128/Mcb.9.10.4229  1
1989 Pan ZQ, Ge H, Fu XY, Manley JL, Prives C. Oligonucleotide-targeted degradation of U1 and U2 snRNAs reveals differential interactions of simian virus 40 pre-mRNAs with snRNPs. Nucleic Acids Research. 17: 6553-68. PMID 2550896 DOI: 10.1093/Nar/17.16.6553  0.92
1989 Noble JC, Ge H, Chaudhuri M, Manley JL. Factor interactions with the simian virus 40 early pre-mRNA influence branch site selection and alternative splicing. Molecular and Cellular Biology. 9: 2007-17. PMID 2546057 DOI: 10.1128/Mcb.9.5.2007  0.76
1988 Fu XY, Colgan JD, Manley JL. Multiple cis-acting sequence elements are required for efficient splicing of simian virus 40 small-t antigen pre-mRNA. Molecular and Cellular Biology. 8: 3582-90. PMID 2851720 DOI: 10.1128/Mcb.8.9.3582  1
1988 Noble JC, Prives C, Manley JL. Alternative splicing of SV40 early pre-mRNA is determined by branch site selection. Genes & Development. 2: 1460-75. PMID 2850262 DOI: 10.1101/Gad.2.11.1460  0.32
1988 Fu XY, Ge H, Manley JL. The role of the polypyrimidine stretch at the SV40 early pre-mRNA 3' splice site in alternative splicing. The Embo Journal. 7: 809-17. PMID 2840286 DOI: 10.1002/J.1460-2075.1988.Tb02879.X  0.92
1988 Connelly S, Manley JL. A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II. Genes & Development. 2: 440-52. PMID 2836265  1
1988 Takagaki Y, Ryner LC, Manley JL. Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylation. Cell. 52: 731-42. PMID 2830992 DOI: 10.1016/0092-8674(88)90411-4  1
1987 Noble JC, Pan ZQ, Prives C, Manley JL. Splicing of SV40 early pre-mRNA to large T and small t mRNAs utilizes different patterns of lariat branch sites. Cell. 50: 227-36. PMID 3036371 DOI: 10.1016/0092-8674(87)90218-2  0.32
1987 Grass DS, Jove R, Manley JL. RNA polymerase II terminates transcription in vitro in the SV40 origin region. Nucleic Acids Research. 15: 4417-36. PMID 3035493 DOI: 10.1093/Nar/15.11.4417  1
1987 Grass DS, Manley JL. Selective translation initiation on bicistronic simian virus 40 late mRNA. Journal of Virology. 61: 2331-5. PMID 3035232  1
1987 Ryner LC, Manley JL. Requirements for accurate and efficient mRNA 3' end cleavage and polyadenylation of a simian virus 40 early pre-RNA in vitro. Molecular and Cellular Biology. 7: 495-503. PMID 3031477  1
1987 Fu XY, Manley JL. Factors influencing alternative splice site utilization in vivo. Molecular and Cellular Biology. 7: 738-48. PMID 3029566 DOI: 10.1128/Mcb.7.2.738  0.92
1987 Grass DS, Read D, Lewis ED, Manley JL. Cell- and promoter-specific activation of transcription by DNA replication. Genes & Development. 1: 1065-74. PMID 2828163 DOI: 10.1101/Gad.1.10.1065  1
1986 Noble JC, Prives C, Manley JL. In vitro splicing of simian virus 40 early pre mRNA. Nucleic Acids Research. 14: 1219-35. PMID 3005968 DOI: 10.1093/Nar/14.3.1219  1
1986 Grass DS, Manley JL. Effects of the adenovirus 2 late promoter on simian virus 40 transcription and replication. Journal of Virology. 57: 129-37. PMID 3001338  1
1985 Sadofsky M, Connelly S, Manley JL, Alwine JC. Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing. Molecular and Cellular Biology. 5: 2713-9. PMID 3016512 DOI: 10.1128/Mcb.5.10.2713  1
1985 Manley JL, Yu H, Ryner L. RNA sequence containing hexanucleotide AAUAAA directs efficient mRNA polyadenylation in vitro. Molecular and Cellular Biology. 5: 373-9. PMID 2579321  1
1984 Fradin A, Jove R, Hemenway C, Keiser HD, Manley JL, Prives C. Splicing pathways of SV40 mRNAs in X. laevis oocytes differ in their requirements for snRNPs. Cell. 37: 927-36. PMID 6086149 DOI: 10.1016/0092-8674(84)90427-6  0.32
1983 Chen S, Grass DS, Blanck G, Hoganson N, Manley JL, Pollack RE. A functional simian virus 40 origin of replication is required for the generation of a super T antigen with a molecular weight of 100,000 in transformed mouse cells. Journal of Virology. 48: 492-502. PMID 6312105  1
1983 Mitsialis SA, Manley JL, Guntaka RV. Localization of active promoters for eucaryotic RNA polymerase II in the long terminal repeat of avian sarcoma virus DNA. Molecular and Cellular Biology. 3: 811-8. PMID 6306447  1
1983 Manley JL, Fire A, Samuels M, Sharp PA. In vitro transcription: whole-cell extract. Methods in Enzymology. 101: 568-82. PMID 6193397 DOI: 10.1016/0076-6879(83)01038-1  0.6
1982 Manley JL, Sharp PA, Gefter ML. Rna synthesis in isolated nuclei processing of adenovirus serotype 2 late messenger rna precursors. Journal of Molecular Biology. 159: 581-99. PMID 6183434 DOI: 10.1016/0022-2836(82)90102-4  0.96
1981 Fire A, Baker CC, Manley JL, Ziff EB, Sharp PA. In vitro transcription of adenovirus. Journal of Virology. 40: 703-19. PMID 7321101 DOI: 10.1128/Jvi.40.3.703-719.1981  1
1981 Spritz RA, Jagadeeswaran P, Choudary PV, Biro PA, Elder JT, deRiel JK, Manley JL, Gefter ML, Forget BG, Weissman SM. Base substitution in an intervening sequence of a beta+-thalassemic human globin gene. Proceedings of the National Academy of Sciences of the United States of America. 78: 2455-9. PMID 6264477 DOI: 10.1073/Pnas.78.4.2455  1
1981 Manley JL, Gefter ML. Transcription of mammalian genes in vitro. Gene Amplification and Analysis. 2: 369-82. PMID 6101055  0.96
1980 Manley JL, Fire A, Cano A, Sharp PA, Gefter ML. DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract. Proceedings of the National Academy of Sciences of the United States of America. 77: 3855-9. PMID 6933441 DOI: 10.1073/Pnas.77.7.3855  0.96
1980 Proudfoot NJ, Shander MH, Manley JL, Gefter ML, Maniatis T. Structure and in vitro transcription of human globin genes. Science (New York, N.Y.). 209: 1329-36. PMID 6158093 DOI: 10.1126/Science.6158093  1
1979 Manley JL, Sharp PA, Gefter ML. RNA synthesis in isolated nuclei: identification and comparison of adenovirus 2 encoded transcripts synthesized in vitro and vivo. Journal of Molecular Biology. 135: 171-97. PMID 529286 DOI: 10.1016/0022-2836(79)90346-2  0.96
1979 Manley JL, Sharp PA, Gefter ML. RNA synthesis in isolated nuclei: in vitro initiation of adenovirus 2 major late mRNA precursor. Proceedings of the National Academy of Sciences of the United States of America. 76: 160-4. PMID 284328 DOI: 10.1073/Pnas.76.1.160  0.96
1978 Manley JL, Gesteland RF. Suppression of amber mutants in vitro induced by low temperature. Journal of Molecular Biology. 125: 433-47. PMID 105144 DOI: 10.1016/0022-2836(78)90309-1  1
1973 Manley J, Reiness G, Zubay G, Gefter ML. Cell-free synthesis of SU+ III tyrosyl transfer RNA: Characterization of the 4S product Archives of Biochemistry and Biophysics. 157: 50-54. PMID 4716962 DOI: 10.1016/0003-9861(73)90388-3  0.96
1973 Chambers DA, Manley JL. On the nature of -galactosidase synthesized by DNA-directed cell-free system. Molecular & General Genetics : Mgg. 120: 301-8. PMID 4686985 DOI: 10.1007/BF00268144  1
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