Jack N. Wells - Publications

Affiliations: 
Pharmacology Vanderbilt University, Nashville, TN 
Area:
Pharmacology, Biochemistry, Molecular Biology
Website:
http://www.mc.vanderbilt.edu/reporter/index.html?ID=2764

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2001 Feoktistov I, Garland EM, Goldstein AE, Zeng D, Belardinelli L, Wells JN, Biaggioni I. Inhibition of human mast cell activation with the novel selective adenosine A(2B) receptor antagonist 3-isobutyl-8-pyrrolidinoxanthine (IPDX)(2). Biochemical Pharmacology. 62: 1163-73. PMID 11705449 DOI: 10.1016/S0006-2952(01)00765-1  1
2001 Dawson ES, Wells JN. Determination of amino acid residues that are accessible from the ligand binding crevice in the seventh transmembrane-spanning region of the human A(1) adenosine receptor. Molecular Pharmacology. 59: 1187-95. PMID 11306703  1
2000 Scholl DJ, Wells JN. Serine and alanine mutagenesis of the nine native cysteine residues of the human A(1) adenosine receptor. Biochemical Pharmacology. 60: 1647-54. PMID 11077047 DOI: 10.1016/S0006-2952(00)00474-3  1
1998 Corbin JD, Beasley A, Turko IV, Haik TL, Mangum KA, Wells JN, Francis SH, Sekhar KR. A photoaffinity probe covalently modifies the catalytic site of the cGMP-binding cGMP-specific phosphodiesterase (PDE-5). Cell Biochemistry and Biophysics. 29: 145-57. PMID 9631243 DOI: 10.1007/BF02737833  1
1998 Feoktistov I, Wells JN, Biaggioni I. Adenosine A(2B) receptors as therapeutic targets Drug Development Research. 45: 198-206.  1
1996 Kennedy AP, Mangum KC, Linden J, Wells JN. Covalent modification of transmembrane span III of the A1 adenosine receptor with an antagonist photoaffinity probe. Molecular Pharmacology. 50: 789-98. PMID 8863823  1
1996 Saunders C, Keefer JR, Kennedy AP, Wells JN, Limbird LE. Receptors coupled to pertussis toxin-sensitive G-proteins traffic to opposite surfaces in Madin-Darby canine kidney cells. A1 adenosine receptors achieve apical and alpha 2A adrenergic receptors achieve basolateral localization. The Journal of Biological Chemistry. 271: 995-1002. PMID 8557716  1
1995 Carey EL, Robertson D, Wells JN, Robertson RM. Contraction of isolated porcine coronary arteries is inhibited by high concentrations of propranolol. Angiology. 46: 453-60. PMID 7785786 DOI: 10.1177/000331979504600601  1
1994 Pong AS, Wells JN. Proteolysis of a membrane-bound protein in polyacrylamide gel slices using freeze-pulverization and gel electrophoresis techniques. Analytical Biochemistry. 217: 163-5. PMID 8203735 DOI: 10.1006/abio.1994.1101  1
1994 Piersen CE, True CD, Wells JN. 125I-2-[4-[2-[2-[(4-azidophenyl)methylcarbonylamino] ethylaminocarbonyl]ethyl]phenyl] ethylamino-5'-N-ethylcarboxamidoadenosine labels transmembrane span V of the A2a adenosine receptor. Molecular Pharmacology. 45: 871-7. PMID 8190104  1
1994 Piersen CE, True CD, Wells JN. A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding. Molecular Pharmacology. 45: 861-70. PMID 8190103  1
1992 Sekhar KR, Hatchett RJ, Shabb JB, Wolfe L, Francis SH, Wells JN, Jastorff B, Butt E, Chakinala MM, Corbin JD. Relaxation of pig coronary arteries by new and potent cGMP analogs that selectively activate type I alpha, compared with type I beta, cGMP-dependent protein kinase. Molecular Pharmacology. 42: 103-8. PMID 1321950  1
1991 Guthrie TS, Tsuji J, Wells JN. A synthetic pseudosubstrate peptide of protein kinase C inhibits the phorbol-12,13-dibutyrate effect on permeabilized coronary artery smooth muscle. Molecular Pharmacology. 39: 621-4. PMID 2034234  1
1990 Kuan CJ, Wells JN, Jackson EK. Endogenous adenosine restrains renin release in conscious rats. Circulation Research. 66: 637-46. PMID 2407369  1
1990 Zhang Y, Wells JN. The effects of chronic caffeine administration on peripheral adenosine receptors. The Journal of Pharmacology and Experimental Therapeutics. 254: 757-63. PMID 2395110  1
1990 Katsushima T, Nieves L, Wells JN. Structure-activity relationships of 8-cycloalkyl-1,3-dipropylxanthines as antagonists of adenosine receptors. Journal of Medicinal Chemistry. 33: 1906-10. PMID 1694546 DOI: 10.1021/jm00169a012  1
1990 Zhang Y, Wells JN. Effects of chronic caffeine administration on peripheral adenosine receptors Journal of Pharmacology and Experimental Therapeutics. 254: 270-276.  1
1989 Kuan CJ, Wells JN, Jackson EK. Endogenous adenosine restrains renin release during sodium restriction. The Journal of Pharmacology and Experimental Therapeutics. 249: 110-6. PMID 2651649  1
1988 Corbin JD, Cobb CE, Beebe SJ, Granner DK, Koch SR, Gettys TW, Blackmore PF, Francis SH, Wells JN. Mechanism and function of cAMP- and cGMP-dependent protein kinases. Advances in Second Messenger and Phosphoprotein Research. 21: 75-86. PMID 3137961  1
1988 Francis SH, Noblett BD, Todd BW, Wells JN, Corbin JD. Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Molecular Pharmacology. 34: 506-17. PMID 2845250  1
1988 Miller-Hance WC, Miller JR, Wells JN, Stull JT, Kamm KE. Biochemical events associated with activation of smooth muscle contraction. The Journal of Biological Chemistry. 263: 13979-82. PMID 2844749  1
1988 Miot F, Keppens S, Erneux C, Wells JN, De Wulf H. Involvement of a plasma membrane phosphodiesterase in the negative control of cyclic AMP levels by vasopressin in rat hepatocytes. Biochemical Pharmacology. 37: 3447-53. PMID 2844189 DOI: 10.1016/0006-2952(88)90695-8  1
1988 Miller JR, Wells JN. Estimating the association of phosphodiesterase with calmodulin in intact cells. Methods in Enzymology. 159: 594-604. PMID 2842622  1
1988 Graber SE, Clancey MA, Wells JN, Gerzer R. A novel mechanism of soluble guanylate cyclase stimulation: time-dependent activation by bacterial lipopolysaccharide in rat fetal spleen cells. Biochimica Et Biophysica Acta. 972: 331-8. PMID 2461743 DOI: 10.1016/0167-4889(88)90209-1  1
1988 Wells JN, Miller JR. Methylxanthine inhibitors of phosphodiesterases. Methods in Enzymology. 159: 489-96. PMID 2457788  1
1987 Martinson EA, Johnson RA, Wells JN. Potent adenosine receptor antagonists that are selective for the A1 receptor subtype. Molecular Pharmacology. 31: 247-52. PMID 3561384  1
1987 Kuan CJ, Wells JN, Jackson EK. Role of endogenous adenosine as a modulator of the renin response to salt restriction. NÉPhrologie. 8: 283-6. PMID 3330576  1
1986 Miller JR, Hawkins DJ, Wells JN. Phorbol diesters alter the contractile responses of porcine coronary artery. The Journal of Pharmacology and Experimental Therapeutics. 239: 38-42. PMID 3463739  1
1986 Keravis TM, Duemler BH, Wells JN. Calmodulin sensitive phosphodiesterase of porcine cerebral cortex: kinetic behavior, calmodulin activation, and stability. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 11: 365-72. PMID 3040819  1
1986 Sullivan TA, Duemler BH, Kuttesch NJ, Keravis TM, Wells JN. Irreversible inhibition of calmodulin-sensitive cyclic nucleotide phosphodiesterase. Journal of Cyclic Nucleotide and Protein Phosphorylation Research. 11: 355-64. PMID 2442214  1
1986 Schneller SW, Ibay AC, Martinson EA, Wells JN. Inhibition of cyclic nucleotide phosphodiesterases from pig coronary artery by benzo-separated analogues of 3-isobutyl-1-methylxanthine. Journal of Medicinal Chemistry. 29: 972-8. PMID 2423691  1
1986 Tanner LI, Harden TK, Wells JN, Martin MW. Identification of the phosphodiesterase regulated by muscarinic cholinergic receptors of 1321N1 human astrocytoma cells. Molecular Pharmacology. 29: 455-60. PMID 2422535  1
1985 Giedroc DP, Keravis TM, Staros JV, Ling N, Wells JN, Puett D. Functional properties of covalent beta-endorphin peptide/calmodulin complexes. Chlorpromazine binding and phosphodiesterase activation. Biochemistry. 24: 1203-11. PMID 3006746  1
1985 Saitoh Y, Hardman JG, Wells JN. Differences in the association of calmodulin with cyclic nucleotide phosphodiesterase in relaxed and contracted arterial strips. Biochemistry. 24: 1613-8. PMID 2988604  1
1985 Miller JR, Hawkins DJ, Wells JN. Phorbol ester increases coronary artery tension and sensitivity to histamine Federation Proceedings. 44.  1
1985 Tanner LI, Harden TK, Wells JN, Martin MW. Indirect identification of the phosphodiesterase (PDE) isozyme regulated by muscarinic receptors (MR) in astrocytoma cells Federation Proceedings. 44.  1
1984 Miot F, Erneux C, Wells JN, Dumont JE. The effects of alkylated xanthines on cyclic AMP accumulation in dog thyroid slices exposed to carbamylcholine. Molecular Pharmacology. 25: 261-6. PMID 6321949  1
1984 Dumont JE, Miot F, Erneux C, Couchie D, Cochaux P, Gervy-Decoster C, Van Sande J, Wells JN. Negative regulation of cyclic AMP levels by activation of cyclic nucleotide phosphodiesterases: the example of the dog thyroid. Advances in Cyclic Nucleotide and Protein Phosphorylation Research. 16: 325-36. PMID 6202125  1
1983 Nemecek GM, Chamberlain RH, Wells JN. Xanthine accumulation by normal and SV40-transformed WI-38 fibroblasts. Biochemical Pharmacology. 32: 1134-7. PMID 6301509 DOI: 10.1016/0006-2952(83)90641-X  1
1983 Lorenz KL, Wells JN. Potentiation of the effects of sodium nitroprusside and of isoproterenol by selective phosphodiesterase inhibitors. Molecular Pharmacology. 23: 424-30. PMID 6300651  1
1983 Wells JN, Miller JR. Inhibition of cyclic nucleotide phosphodiesterases in muscle Trends in Pharmacological Sciences. 4: 385-387. DOI: 10.1016/0165-6147(83)90456-X  1
1982 Saitoh Y, Wells JN, Hardman JG. Trifluoperazine TFP can prevent activation of phosphodiesterase (PD) by calmodulin plus Ca2+ (AM-Ca2+) at 4° without causing extensive inactivation of preformed PD-CAM-Ca2+ Federation Proceedings. 41: No. 8530.  1
1982 Carey EL, Robertson D, Wells JN, Robertson RM. Contraction of isolated porcine coronary arteries is inhibited by propranolol American Journal of Cardiology. 49: 941.  1
1981 Wells JN, Garst JE, Kramer GL. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from pig coronary arteries by 1,3-disubstituted and 1,3,8-trisubstituted xanthines. Journal of Medicinal Chemistry. 24: 954-8. PMID 6276544  1
1981 Weiss RM, Hardman JG, Wells JN. Resistance of a separated form of canine ureteral phosphodiesterase activity to inhibition by xanthines and papaverine. Biochemical Pharmacology. 30: 2371-4. PMID 6271142 DOI: 10.1016/0006-2952(81)90117-9  1
1981 Mushlin P, Boerth RC, Wells JN. Xanthine derivatives that selectively inhibit cyclic GMP hydrolysis potentiate cardiac contractile effects of isoproterenol but not those of bethanecol. Molecular Pharmacology. 20: 190-4. PMID 6270532  1
1981 Mushlin P, Boerth RC, Wells JN. Selective phosphodiesterase inhibition and alterations of cardiac function by alkylated xanthines. Molecular Pharmacology. 20: 179-89. PMID 6270531  1
1981 Wells JN, Kramer GL. Phosphodiesterase inhibitors as tools in cyclic nucleotide research: a precautionary comment. Molecular and Cellular Endocrinology. 23: 1-9. PMID 6167475 DOI: 10.1016/0303-7207(81)90112-X  1
1980 Nemecek GM, Wells JN, Butcher RW. Inhibition of fibroblast cyclic AMP escape and cyclic nucleotide phosphodiesterase activities by xanthines. Molecular Pharmacology. 18: 57-64. PMID 6251359  1
1980 Coquil JF, Franks DJ, Wells JN, Dupuis M, Hamet P. Characteristics of a new binding protein distinct from the kinase for guanosine 3':5'-monophosphate in rat platelets. Biochimica Et Biophysica Acta. 631: 148-65. PMID 6249389 DOI: 10.1016/0304-4165(80)90063-X  1
1980 Kramer GL, Wells JN. Xanthines and skeletal muscle: lack of relationship between phosphodiesterase inhibition and increased twitch tension in rat diaphragms. Molecular Pharmacology. 17: 73-8. PMID 6247639  1
1980 Keravis TM, Wells JN, Hardman JG. Cyclic nucleotide phosphodiesterase activities from pig coronary arteries. Lack of interconvertibility of major forms. Biochimica Et Biophysica Acta. 613: 116-29. PMID 6246952 DOI: 10.1016/0005-2744(80)90198-9  1
1979 Kramer GL, Wells JN. Effects of phosphodiesterase inhibitors on cyclic nucleotide levels and relaxation of pig coronary arteries. Molecular Pharmacology. 16: 813-22. PMID 231194  1
1979 Smellie FW, Davis CW, Daly JW, Wells JN. Alkylxanthines: Inhibition of adenosine-elicited accumulation of cyclic AMP in brain slices and of brain phosphodiesterase activity Life Sciences. 24: 2475-2481. PMID 225626 DOI: 10.1016/0024-3205(79)90458-2  1
1979 Smellie FW, Daly JW, Wells JN. 1-Isoamyl-3-isobutylxanthine: A remarkably potent agent for the potentiation of norepinephrine, histamine, and adenosine-elicited accumulations of cyclic AMP in brain slices Life Sciences. 25: 1917-1924. PMID 93674 DOI: 10.1016/0024-3205(79)90613-1  1
1979 Kramer GL, Wells JN. Effects of xanthines to inhibit phosphodiesterase (PD) and increase contraction in skeletal muscle Federation Proceedings. 38.  1
1979 Weiss RM, Hardman JG, Wells JN. Ureteral phosphodiesterase (PD) activity: Resistance of a separated form to inhibition by xanthines and papaverine Federation Proceedings. 38: No.196.  1
1979 Nemecek GM, Wells JN, Butcher RW. Inhibition of fibroblast phosphodiesterases (PDEs) and cyclic AMP (cAMP) escape by xanthines Federation Proceedings. 38.  1
1978 Mushlin P, Boerth RC, Wells JN. Selective inhibition of cardiac phosphodiesterases and alteration of atrial function by methylxanthines Circulation. 58.  1
1977 Wells JN, Hardman JG. Cyclic nucleotide phosphodiesterases. Advances in Cyclic Nucleotide Research. 8: 119-43. PMID 200125  1
1977 Kramer GL, Garst JE, Mitchel SS, Wells JN. Selective inhibition of cyclic nucleotide phosphodiesterases by analogues of 1-methyl-3-isobutylxanthine. Biochemistry. 16: 3316-21. PMID 196632  1
1977 Kramer GL, Wells JN. Effects of phosphodiesterase (PD) inhibitors on cyclic nucleotide levels and relaxation of coronary arteries Pharmacologist. 19.  1
1977 Kramer GL, Garst JE, Wells JN. Structural requirements for inhibition of cyclic nucleotide phosphodiesterase (PD) by analogs of 1 methyl 3 isobutylxanthine (MIX) Federation Proceedings. 36.  1
1976 Wells JN, Garbers DL. Nucleoside 3',5'-monophosphate phosphodiesterases in sea urchin sperm. Biology of Reproduction. 15: 46-53. PMID 182290  1
1976 Garst JE, Kramer GL, Wu YJ, Wells JN. Inhibition of separated forms of phosphodiesterases from pig coronary arteries by uracils and by 7-substituted derivatives of 1-methyl-3-isobutylxanthine. Journal of Medicinal Chemistry. 19: 499-503. PMID 177782  1
1976 Wells JN, Garst JE, Kramer GL, Garbers DL. Selective inhibitors of cyclic nucleotide phosphodiesterases (PD) Federation Proceedings. 35.  1
1975 Wells JN, Wu YJ, Baird CE, Hardman JG. Phosphodiesterases from porcine coronary arteries: inhibition of separated forms by xanthines, papaverine, and cyclic nucleotides. Molecular Pharmacology. 11: 775-83. PMID 173982  1
1975 Wells JN, Baird CE, Wu YJ, Hardman JG. Cyclic nucleotide phosphodiesterase activities of pig coronary arteries Bba - Enzymology. 384: 430-442. PMID 164919 DOI: 10.1016/0005-2744(75)90044-3  1
1974 Wells JN, Baird CE, Hardman JG. Inhibition of cyclic AMP (cA) and cyclic GMP (cG) phosphodiesterase (PD) activities from pig coronary arteries Federation Proceedings. 33: I.  1
1964 Burckhalter JH, Wells JN, Mayer WJ. Mechanism of the mannich reaction involving 2,4-dimethylphenol and morpholine Tetrahedron Letters. 5: 1353-1359.  1
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