Robert S. Fuller - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
proprotein processing and protein localization in yeast

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 De M, Oleskie AN, Ayyash M, Dutta S, Mancour L, Abazeed ME, Brace EJ, Skiniotis G, Fuller RS. The Vps13p-Cdc31p complex is directly required for TGN late endosome transport and TGN homotypic fusion. The Journal of Cell Biology. PMID 28122955 DOI: 10.1083/jcb.201606078  0.92
2014 Yang RT, Lim GL, Yee CT, Fuller RS, Ritchie HH. Site specificity of DSP-PP cleavage by BMP1. Connective Tissue Research. 55: 142-5. PMID 25158199 DOI: 10.3109/03008207.2014.923863  1
2013 De M, Abazeed ME, Fuller RS. Direct binding of the Kex2p cytosolic tail to the VHS domain of yeast Gga2p facilitates TGN to prevacuolar compartment transport and is regulated by phosphorylation. Molecular Biology of the Cell. 24: 495-509. PMID 23408788 DOI: 10.1091/mbc.E12-11-0843  1
2013 Yang RT, Lim GL, Dong Z, Lee AM, Yee CT, Fuller RS, Ritchie HH. The efficiency of dentin sialoprotein-phosphophoryn processing is affected by mutations both flanking and distant from the cleavage site. The Journal of Biological Chemistry. 288: 6024-33. PMID 23297400 DOI: 10.1074/jbc.M112.382952  1
2013 Fuller RS. Kexin Handbook of Proteolytic Enzymes. 3: 3270-3277. DOI: 10.1016/B978-0-12-382219-2.00722-5  1
2013 Fuller RS. Yapsin 2 Handbook of Proteolytic Enzymes. 1: 180-182. DOI: 10.1016/B978-0-12-382219-2.00039-9  1
2012 Ritchie HH, Yee CT, Tang XN, Dong Z, Fuller RS. DSP-PP precursor protein cleavage by tolloid-related-1 protein and by bone morphogenetic protein-1. Plos One. 7: e41110. PMID 22815932 DOI: 10.1371/journal.pone.0041110  1
2009 Komiyama T, Coppola JM, Larsen MJ, van Dort ME, Ross BD, Day R, Rehemtulla A, Fuller RS. Inhibition of furin/proprotein convertase-catalyzed surface and intracellular processing by small molecules. The Journal of Biological Chemistry. 284: 15729-38. PMID 19332539 DOI: 10.1074/jbc.M901540200  1
2008 Abazeed ME, Fuller RS. Yeast Golgi-localized, gamma-Ear-containing, ADP-ribosylation factor-binding proteins are but adaptor protein-1 is not required for cell-free transport of membrane proteins from the trans-Golgi network to the prevacuolar compartment. Molecular Biology of the Cell. 19: 4826-36. PMID 18784256 DOI: 10.1091/mbc.E07-05-0442  1
2008 Fuller RS. A tribute to Arthur Kornberg 1918-2007. Nature Structural & Molecular Biology. 15: 2-17. PMID 18176549 DOI: 10.1038/nsmb0108-2  1
2006 Brace EJ, Parkinson LP, Fuller RS. Skp1p regulates Soi3p/Rav1p association with endosomal membranes but is not required for vacuolar ATPase assembly. Eukaryotic Cell. 5: 2104-13. PMID 17041187 DOI: 10.1128/EC.00347-05  1
2005 Komiyama T, Swanson JA, Fuller RS. Protection from anthrax toxin-mediated killing of macrophages by the combined effects of furin inhibitors and chloroquine. Antimicrobial Agents and Chemotherapy. 49: 3875-82. PMID 16127065 DOI: 10.1128/AAC.49.9.3875-3882.2005  1
2005 Krysan DJ, Ting EL, Abeijon C, Kroos L, Fuller RS. Yapsins are a family of aspartyl proteases required for cell wall integrity in Saccharomyces cerevisiae. Eukaryotic Cell. 4: 1364-74. PMID 16087741 DOI: 10.1128/EC.4.8.1364-1374.2005  1
2005 Abazeed ME, Blanchette JM, Fuller RS. Cell-free transport from the trans-golgi network to late endosome requires factors involved in formation and consumption of clathrin-coated vesicles. The Journal of Biological Chemistry. 280: 4442-50. PMID 15572353 DOI: 10.1074/jbc.M412553200  1
2004 Blanchette JM, Abazeed ME, Fuller RS. Cell-free reconstitution of transport from the trans-golgi network to the late endosome/prevacuolar compartment. The Journal of Biological Chemistry. 279: 48767-73. PMID 15364946 DOI: 10.1074/jbc.M406368200  1
2004 Rozan L, Krysan DJ, Rockwell NC, Fuller RS. Plasticity of extended subsites facilitates divergent substrate recognition by Kex2 and furin. The Journal of Biological Chemistry. 279: 35656-63. PMID 15159396 DOI: 10.1074/jbc.M405362200  1
2004 Podsiadlo P, Komiyama T, Fuller RS, Blum O. Furin inhibition by compounds of copper and zinc. The Journal of Biological Chemistry. 279: 36219-27. PMID 15140896 DOI: 10.1074/jbc.M400338200  1
2004 Sipos G, Brickner JH, Brace EJ, Chen L, Rambourg A, Kepes F, Fuller RS. Soi3p/Rav1p functions at the early endosome to regulate endocytic trafficking to the vacuole and localization of trans-Golgi network transmembrane proteins. Molecular Biology of the Cell. 15: 3196-209. PMID 15090613 DOI: 10.1091/mbc.E03-10-0755  1
2004 Holyoak T, Kettner CA, Petsko GA, Fuller RS, Ringe D. Structural basis for differences in substrate selectivity in Kex2 and furin protein convertases. Biochemistry. 43: 2412-21. PMID 14992578 DOI: 10.1021/bi035849h  1
2003 Komiyama T, VanderLugt B, Fugère M, Day R, Kaufman RJ, Fuller RS. Optimization of protease-inhibitor interactions by randomizing adventitious contacts. Proceedings of the National Academy of Sciences of the United States of America. 100: 8205-10. PMID 12832612 DOI: 10.1073/pnas.1032865100  1
2003 Holyoak T, Wilson MA, Fenn TD, Kettner CA, Petsko GA, Fuller RS, Ringe D. 2.4 A resolution crystal structure of the prototypical hormone-processing protease Kex2 in complex with an Ala-Lys-Arg boronic acid inhibitor. Biochemistry. 42: 6709-18. PMID 12779325 DOI: 10.1021/bi034434t  1
2002 Rockwell NC, Krysan DJ, Komiyama T, Fuller RS. Precursor processing by kex2/furin proteases. Chemical Reviews. 102: 4525-48. PMID 12475200 DOI: 10.1021/cr010168i  1
2002 Brinkerhoff CJ, Podsiadlo P, Komiyama T, Fuller RS, Blum O. Protease inhibitors formed in situ from copper and tridentate chelates: a generalized approach towards metal-based pharmaceuticals. Chembiochem : a European Journal of Chemical Biology. 3: 1141-3. PMID 12404642 DOI: 10.1002/1439-7633(20021104)3:11<1141::AID-CBIC1141>3.0.CO;2-7  1
2002 Sipos G, Fuller RS. Separation of Golgi and endosomal compartments. Methods in Enzymology. 351: 351-65. PMID 12073356 DOI: 10.1016/S0076-6879(02)51857-7  1
2002 Rockwell NC, Fuller RS. Specific modulation of Kex2/furin family proteases by potassium. The Journal of Biological Chemistry. 277: 17531-7. PMID 11893737 DOI: 10.1074/jbc.M111909200  1
2002 Rockwell NC, Fuller RS. 10 Yeast Kex2 protease Enzymes. 22: 259-289. DOI: 10.1016/S1874-6047(02)80011-7  1
2001 Brickner JH, Blanchette JM, Sipos G, Fuller RS. The Tlg SNARE complex is required for TGN homotypic fusion. The Journal of Cell Biology. 155: 969-78. PMID 11739408 DOI: 10.1083/jcb.200104093  1
2001 Rockwell NC, Fuller RS. Differential utilization of enzyme-substrate interactions for acylation but not deacylation during the catalytic cycle of Kex2 protease. The Journal of Biological Chemistry. 276: 38394-9. PMID 11514565 DOI: 10.1074/jbc.M105782200  1
2001 MacLeod KJ, Fuller RS, Scholten JD, Ahn K. Conserved cysteine and tryptophan residues of the endothelin-converting enzyme-1 CXAW motif are critical for protein maturation and enzyme activity. The Journal of Biological Chemistry. 276: 30608-14. PMID 11397811 DOI: 10.1074/jbc.M103928200  1
2001 Rockwell NC, Fuller RS. Direct measurement of acylenzyme hydrolysis demonstrates rate-limiting deacylation in cleavage of physiological sequences by the processing protease Kex2. Biochemistry. 40: 3657-65. PMID 11297433 DOI: 10.1021/bi0020877  1
2000 Komiyama T, Fuller RS. Engineered eglin c variants inhibit yeast and human proprotein processing proteases, Kex2 and furin. Biochemistry. 39: 15156-65. PMID 11106495 DOI: 10.1021/bi001907c  1
2000 Rockwell NC, Krysan DJ, Fuller RS. Synthesis of peptidyl methylcoumarin esters as substrates and active-site titrants for the prohormone processing proteases Kex2 and PC2. Analytical Biochemistry. 280: 201-8. PMID 10790301 DOI: 10.1006/abio.2000.4541  1
2000 Hwang JR, Siekhaus DE, Fuller RS, Taghert PH, Lindberg I. Interaction of Drosophila melanogaster prohormone convertase 2 and 7B2. Insect cell-specific processing and secretion. The Journal of Biological Chemistry. 275: 17886-93. PMID 10749852 DOI: 10.1074/jbc.M000032200  1
1999 Komano H, Rockwell N, Wang GT, Krafft GA, Fuller RS. Purification and characterization of the yeast glycosylphosphatidylinositol-anchored, monobasic-specific aspartyl protease yapsin 2 (Mkc7p). The Journal of Biological Chemistry. 274: 24431-7. PMID 10446224 DOI: 10.1074/jbc.274.34.24431  1
1999 Krysan DJ, Rockwell NC, Fuller RS. Quantitative characterization of furin specificity. Energetics of substrate discrimination using an internally consistent set of hexapeptidyl methylcoumarinamides. The Journal of Biological Chemistry. 274: 23229-34. PMID 10438496 DOI: 10.1074/jbc.274.33.23229  1
1999 Siekhaus DE, Fuller RS. A role for amontillado, the Drosophila homolog of the neuropeptide precursor processing protease PC2, in triggering hatching behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6942-54. PMID 10436051  1
1998 Komano H, Seeger M, Gandy S, Wang GT, Krafft GA, Fuller RS. Involvement of cell surface glycosyl-phosphatidylinositol-linked aspartyl proteases in alpha-secretase-type cleavage and ectodomain solubilization of human Alzheimer beta-amyloid precursor protein in yeast. The Journal of Biological Chemistry. 273: 31648-51. PMID 9822624 DOI: 10.1074/jbc.273.48.31648  1
1998 MacKenzie DA, Kraunsoe JA, Chesshyre JA, Lowe G, Komiyama T, Fuller RS, Archer DB. Aberrant processing of wild-type and mutant bovine pancreatic trypsin inhibitor secreted by Aspergillus niger. Journal of Biotechnology. 63: 137-46. PMID 9772752 DOI: 10.1016/S0168-1656(98)00081-9  1
1998 Bevan A, Brenner C, Fuller RS. Quantitative assessment of enzyme specificity in vivo: P2 recognition by Kex2 protease defined in a genetic system. Proceedings of the National Academy of Sciences of the United States of America. 95: 10384-9. PMID 9724712 DOI: 10.1073/pnas.95.18.10384  1
1998 Rockwell NC, Fuller RS. Interplay between S1 and S4 subsites in Kex2 protease: Kex2 exhibits dual specificity for the P4 side chain. Biochemistry. 37: 3386-91. PMID 9521659 DOI: 10.1021/bi972534r  1
1997 Brickner JH, Fuller RS. SOI1 encodes a novel, conserved protein that promotes TGN-endosomal cycling of Kex2p and other membrane proteins by modulating the function of two TGN localization signals. The Journal of Cell Biology. 139: 23-36. PMID 9314526 DOI: 10.1083/jcb.139.1.23  1
1997 Kean LS, Grant AM, Angeletti C, Mahé Y, Kuchler K, Fuller RS, Nichols JW. Plasma membrane translocation of fluorescent-labeled phosphatidylethanolamine is controlled by transcription regulators, PDR1 and PDR3. The Journal of Cell Biology. 138: 255-70. PMID 9230069 DOI: 10.1083/jcb.138.2.255  1
1997 Rockwell NC, Wang GT, Krafft GA, Fuller RS. Internally consistent libraries of fluorogenic substrates demonstrate that Kex2 protease specificity is generated by multiple mechanisms. Biochemistry. 36: 1912-7. PMID 9048578 DOI: 10.1021/bi961779l  1
1996 Redding K, Seeger M, Payne GS, Fuller RS. The effects of clathrin inactivation on localization of Kex2 protease are independent of the TGN localization signal in the cytosolic tail of Kex2p. Molecular Biology of the Cell. 7: 1667-77. PMID 8930891  1
1996 Redding K, Brickner JH, Marschall LG, Nichols JW, Fuller RS. Allele-specific suppression of a defective trans-Golgi network (TGN) localization signal in Kex2p identifies three genes involved in localization of TGN transmembrane proteins. Molecular and Cellular Biology. 16: 6208-17. PMID 8887651  1
1995 Komano H, Fuller RS. Shared functions in vivo of a glycosyl-phosphatidylinositol-linked aspartyl protease, Mkc7, and the proprotein processing protease Kex2 in yeast. Proceedings of the National Academy of Sciences of the United States of America. 92: 10752-6. PMID 7479877 DOI: 10.1073/pnas.92.23.10752  1
1994 Gluschankof P, Fuller RS. A C-terminal domain conserved in precursor processing proteases is required for intramolecular N-terminal maturation of pro-Kex2 protease. The Embo Journal. 13: 2280-8. PMID 8194519  1
1994 Zhang H, Komano H, Fuller RS, Gandy SE, Frail DE. Proteolytic processing and secretion of human beta-amyloid precursor protein in yeast. Evidence for a yeast secretase activity. The Journal of Biological Chemistry. 269: 27799-802. PMID 7961704  1
1994 Bravo DA, Gleason JB, Sanchez RI, Roth RA, Fuller RS. Accurate and efficient cleavage of the human insulin proreceptor by the human proprotein-processing protease furin. Characterization and kinetic parameters using the purified, secreted soluble protease expressed by a recombinant baculovirus. The Journal of Biological Chemistry. 269: 25830-7. PMID 7929288  1
1994 Brenner C, Bevan A, Fuller RS. Biochemical and genetic methods for analyzing specificity and activity of a precursor-processing enzyme: yeast Kex2 protease, kexin. Methods in Enzymology. 244: 152-67. PMID 7845204 DOI: 10.1016/0076-6879(94)44013-1  1
1993 Brenner C, Bevan A, Fuller RS. One-step site-directed mutagenesis of the Kex2 protease oxyanion hole. Current Biology : Cb. 3: 498-506. PMID 15335687 DOI: 10.1016/0960-9822(93)90040-U  1
1993 Angliker H, Wikstrom P, Shaw E, Brenner C, Fuller RS. The synthesis of inhibitors for processing proteinases and their action on the Kex2 proteinase of yeast. The Biochemical Journal. 293: 75-81. PMID 8328974  1
1993 Kean LS, Fuller RS, Nichols JW. Retrograde lipid traffic in yeast: identification of two distinct pathways for internalization of fluorescent-labeled phosphatidylcholine from the plasma membrane. The Journal of Cell Biology. 123: 1403-19. PMID 8253840  1
1992 Brenner C, Fuller RS. Structural and enzymatic characterization of a purified prohormone-processing enzyme: secreted, soluble Kex2 protease. Proceedings of the National Academy of Sciences of the United States of America. 89: 922-6. PMID 1736307  1
1992 Wilcox CA, Redding K, Wright R, Fuller RS. Mutation of a tyrosine localization signal in the cytosolic tail of yeast Kex2 protease disrupts Golgi retention and results in default transport to the vacuole. Molecular Biology of the Cell. 3: 1353-71. PMID 1493334  1
1991 Redding K, Holcomb C, Fuller RS. Immunolocalization of Kex2 protease identifies a putative late Golgi compartment in the yeast Saccharomyces cerevisiae. The Journal of Cell Biology. 113: 527-38. PMID 2016334  1
1991 Franzusoff A, Redding K, Crosby J, Fuller RS, Schekman R. Localization of components involved in protein transport and processing through the yeast Golgi apparatus. The Journal of Cell Biology. 112: 27-37. PMID 1986005  1
1991 Wilcox CA, Fuller RS. Posttranslational processing of the prohormone-cleaving Kex2 protease in the Saccharomyces cerevisiae secretory pathway. The Journal of Cell Biology. 115: 297-307. PMID 1918142  1
1989 Fuller RS, Brake AJ, Thorner J. Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science (New York, N.Y.). 246: 482-6. PMID 2683070  1
1989 Fuller RS, Brake A, Thorner J. Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. Proceedings of the National Academy of Sciences of the United States of America. 86: 1434-8. PMID 2646633  1
1988 Thomas G, Thorne BA, Thomas L, Allen RG, Hruby DE, Fuller R, Thorner J. Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells. Science (New York, N.Y.). 241: 226-30. PMID 3291117  1
1988 Fuller RS, Sterne RE, Thorner J. Enzymes required for yeast prohormone processing. Annual Review of Physiology. 50: 345-62. PMID 3288097 DOI: 10.1146/annurev.ph.50.030188.002021  1
1985 Kaguni JM, Bertsch LL, Bramhill D, Flynn JE, Fuller RS, Funnell B, Maki S, Ogawa T, Ogawa K, van der Ende A. Initiation of replication of the Escherichia coli chromosomal origin reconstituted with purified enzymes. Basic Life Sciences. 30: 141-50. PMID 2990405  1
1984 Fuller RS, Funnell BE, Kornberg A. The dnaA protein complex with the E. coli chromosomal replication origin (oriC) and other DNA sites. Cell. 38: 889-900. PMID 6091903 DOI: 10.1016/0092-8674(84)90284-8  1
1984 Funnell BE, Fuller RS, Kaguni JM. Initiation of replication at the E. coli chromosomal origin with purified enzymes Federation Proceedings. 43: no. 1475.  1
1983 Stayton MM, Bertsch L, Biswas S, Burgers P, Dixon N, Flynn JE, Fuller R, Kaguni J, Kobori J, Kodaira M, Low R, Kornberg A. Enzymatic recognition of DNA replication origins. Cold Spring Harbor Symposia On Quantitative Biology. 47: 693-700. PMID 6345074  1
1983 Fuller RS, Kornberg A. Purified dnaA protein in initiation of replication at the Escherichia coli chromosomal origin of replication. Proceedings of the National Academy of Sciences of the United States of America. 80: 5817-21. PMID 6310593  1
1982 Kaguni JM, Fuller RS, Kornberg A. Enzymatic replication of E. coli chromosomal origin is bidirectional. Nature. 296: 623-7. PMID 7040980 DOI: 10.1038/296623a0  1
1981 Fuller RS, Kaguni JM, Kornberg A. Enzymatic replication of the origin of the Escherichia coli chromosome. Proceedings of the National Academy of Sciences of the United States of America. 78: 7370-4. PMID 6278471  1
1978 Fuller RS, Platt T. The attenuator of the tryptophan operon in E.coli: rho-mediated release of RNA polymerase from a transcription termination complex in vitro. Nucleic Acids Research. 5: 4613-23. PMID 370776  1
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