Preethi Krishnan, Ph.D. - Related publications

2000 University of North Carolina, Chapel Hill, Chapel Hill, NC 
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50 most relevant papers in past 60 days:
Year Citation  Score
2020 da Silva Hage-Melim LI, Federico LB, de Oliveira NKS, Francisco VCC, Correa LC, de Lima HB, Gomes SQ, Barcelos MP, Francischini IAG, de Paula da Silva CHT. Virtual screening, ADME/Tox predictions and the drug repurposing concept for future use of old drugs against the COVID-19. Life Sciences. 117963. PMID 32535080 DOI: 10.1016/j.lfs.2020.117963   
2020 Rahman N, Basharat Z, Yousuf M, Castaldo G, Rastrelli L, Khan H. Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2). Molecules (Basel, Switzerland). 25. PMID 32408547 DOI: 10.3390/molecules25102271   
2020 Rensi S, Altman RB, Liu T, Lo YC, McInnes G, Derry A, Keys A. Homology Modeling of TMPRSS2 Yields Candidate Drugs That May Inhibit Entry of SARS-CoV-2 into Human Cells. Chemrxiv : the Preprint Server For Chemistry. PMID 32511288 DOI: 10.26434/chemrxiv.12009582   
2020 Sharma S, Sharma S, Singh PP, Khan IA. Potential Inhibitors Against NDM-1 Type Metallo-β-Lactamases: An Overview. Microbial Drug Resistance (Larchmont, N.Y.). PMID 32486911 DOI: 10.1089/mdr.2019.0315   
2020 Naik B, Gupta N, Ojha R, Singh S, Prajapati VK, Prusty D. High throughput virtual screening reveals SARS-CoV-2 multi-target binding natural compounds to lead instant therapy for COVID-19 treatment. International Journal of Biological Macromolecules. PMID 32470577 DOI: 10.1016/j.ijbiomac.2020.05.184   
2020 Alzhrani ZMM, Alam MM, Neamatallah T, Nazreen S. Design, synthesis and antiproliferative activity of new thiazolidinedione-1,3,4-oxadiazole hybrids as thymidylate synthase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry. 35: 1116-1123. PMID 32354237 DOI: 10.1080/14756366.2020.1759581   
2020 Asemanipoor N, Mohammadi-Khanaposhtani M, Moradi S, Vahidi M, Asadi M, Faramarzi MA, Mahdavi M, Biglar M, Larijani B, Hamedifar H, Hajimiri MH. Synthesis and biological evaluation of new benzimidazole-1,2,3-triazole hybrids as potential α-glucosidase inhibitors. Bioorganic Chemistry. 95: 103482. PMID 31838286 DOI: 10.1016/j.bioorg.2019.103482   
2020 Ali M, Khan KM, Mahdavi M, Jabbar A, Shamim S, Salar U, Taha M, Perveen S, Larijani B, Faramarzi MA. Synthesis, in vitro and in silico screening of 2-amino-4-aryl-6-(phenylthio) pyridine-3,5-dicarbonitriles as novel α-glucosidase inhibitors. Bioorganic Chemistry. 100: 103879. PMID 32413625 DOI: 10.1016/j.bioorg.2020.103879   
2020 Mäder P, Bartholomäus R, Nicolussi S, Baumann A, Weis M, Chicca A, Rau M, Simão AC, Gertsch J, Altmann KH. Synthesis and Biological Evaluation of Endocannabinoid Uptake Inhibitors Derived from WOBE437. Chemmedchem. PMID 32369259 DOI: 10.1002/cmdc.202000153   
2020 Krátký M, Baranyai Z, Štěpánková Š, Svrčková K, Švarcová M, Stolaříková J, Horváth L, Bősze S, Vinšová J. -Alkyl-2-[4-(trifluoromethyl)benzoyl]hydrazine-1-carboxamides and Their Analogues: Synthesis and Multitarget Biological Activity. Molecules (Basel, Switzerland). 25. PMID 32408517 DOI: 10.3390/molecules25102268   
2020 Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Biorxiv : the Preprint Server For Biology. PMID 32511378 DOI: 10.1101/2020.04.20.051581   
2020 Kalčic F, Kolman V, Ajani H, Zídek Z, Janeba Z. Polysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE2 Production with a Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema. Chemmedchem. PMID 32410351 DOI: 10.1002/cmdc.202000258   
2020 Ma C, Sacco MD, Hurst B, Townsend JA, Hu Y, Szeto T, Zhang X, Tarbet B, Marty MT, Chen Y, Wang J. Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease. Cell Research. PMID 32541865 DOI: 10.1038/s41422-020-0356-z   
2020 Tripathi RKP, Patel AD, Pasha TY, Lunagaria P, Shah U, Bhambharoliya T. Design and Synthesis of a Library of Thiazolidin-4-one Derivatives as Protein Tyrosine Phosphatase 1B (PTP1B) Inhibitors: An Attempt to Discover Novel Anti-diabetic Agents. Chemmedchem. PMID 32390300 DOI: 10.1002/cmdc.202000055   
2020 Braun NJ, Quek JP, Huber S, Kouretova J, Rogge D, Lang-Henkel H, Cheong ZKE, Chew BLA, Heine A, Luo D, Steinmetzer T. Structure-based macrocyclization of substrate analog NS2B-NS3 protease inhibitors of Zika, West Nile and Dengue viruses. Chemmedchem. PMID 32501637 DOI: 10.1002/cmdc.202000237   
2020 El Mansouri AE, Maatallah M, Ait Benhassou H, Moumen A, Mehdi A, Snoeck R, Andrei G, Zahouily M, Lazrek HB. Design, synthesis, chemical characterization, biological evaluation, and docking study of new 1,3,4-oxadiazole homonucleoside analogs. Nucleosides, Nucleotides & Nucleic Acids. 1-20. PMID 32397827 DOI: 10.1080/15257770.2020.1761982   
2020 Shaykoon MS, Marzouk AA, Soltan OM, Wanas AS, Radwan MM, Gouda AM, Youssif BGM, Abdel-Aziz M. Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives. Bioorganic Chemistry. 100: 103933. PMID 32446119 DOI: 10.1016/j.bioorg.2020.103933   
2020 Fullington S, Cheng Z, Thomas C, Miller C, Yang K, Ju LC, Bergstrom A, Shurina BA, Bretz SL, Page RC, Tierney DL, Crowder MW. An integrated biophysical approach to discovering mechanisms of NDM-1 inhibition for several thiol-containing drugs. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 32500360 DOI: 10.1007/s00775-020-01794-z   
2020 Han H, Li C, Li M, Yang L, Zhao S, Wang Z, Liu H, Liu D. Design, Synthesis, and Biological Evaluation of 8-Mercapto-3,7-Dihydro-1-Purine-2,6-Diones as Potent Inhibitors of SIRT1, SIRT2, SIRT3, and SIRT5. Molecules (Basel, Switzerland). 25. PMID 32549218 DOI: 10.3390/molecules25122755   
2020 Umesh, Kundu D, Selvaraj C, Singh SK, Dubey VK. Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target. Journal of Biomolecular Structure & Dynamics. 1-9. PMID 32362243 DOI: 10.1080/07391102.2020.1763202   
2020 Ur Rehman N, Halim SA, Al-Azri M, Khan M, Khan A, Rafiq K, Al-Rawahi A, Csuk R, Al-Harrasi A. Triterpenic Acids as Non-Competitive α-Glucosidase Inhibitors from with Structure-Activity Relationship: In Vitro and In Silico Studies. Biomolecules. 10. PMID 32408614 DOI: 10.3390/biom10050751   
2020 Ribeiro JA, Hammer AJS, Libreros-Z Uacute Ntilde Iga GAES, Chavez-Pacheco SM, Tyrakis P, de Oliveira GS, Kirkman T, El Bakali J, Rocco SA, Sforça ML, Parise Filho R, Coyne AG, Blundell TL, Abell C, Dias MVB. Using a fragment-based approach to identify alternative chemical scaffolds targeting dihydrofolate reductase from Mycobacterium tuberculosis. Acs Infectious Diseases. PMID 32603583 DOI: 10.1021/acsinfecdis.0c00263   
2020 Woo HS, Shin KC, Kim JY, Kim YS, Ban YJ, Oh YJ, Cho HJ, Oh DK, Kim DW. Bakkenolides and Caffeoylquinic Acids from the Aerial Portion of and Their Bacterial Neuraminidase Inhibition Ability. Biomolecules. 10. PMID 32532086 DOI: 10.3390/biom10060888   
2020 Philoppes JN, Khedr MA, Hassan MHA, Kamel G, Lamie PF. New pyrazolopyrimidine derivatives with anticancer activity: Design, synthesis, PIM-1 inhibition, molecular docking study and molecular dynamics. Bioorganic Chemistry. 100: 103944. PMID 32450389 DOI: 10.1016/j.bioorg.2020.103944   
2020 Al-Awadhi FH, Luesch H. Targeting eukaryotic proteases for natural products-based drug development. Natural Product Reports. 37: 827-860. PMID 32519686 DOI: 10.1039/c9np00060g   
2020 Juárez-Saldivar A, Schroeder M, Salentin S, Haupt VJ, Saavedra E, Vázquez C, Reyes-Espinosa F, Herrera-Mayorga V, Villalobos-Rocha JC, García-Pérez CA, Campillo NE, Rivera G. Computational Drug Repositioning for Chagas Disease Using Protein-Ligand Interaction Profiling. International Journal of Molecular Sciences. 21. PMID 32560043 DOI: 10.3390/ijms21124270   
2020 Punetha A, Ngo HX, Holbrook SYL, Green KD, Willby MJ, Bonnett SA, Krieger K, Dennis EK, Posey JE, Parish T, Tsodikov OV, Garneau-Tsodikova S. Structure-Guided Optimization of Inhibitors of Acetyltransferase Eis from . Acs Chemical Biology. PMID 32421305 DOI: 10.1021/acschembio.0c00184   
2020 An Y, Dong Y, Min L, Zhao L, Zhao D, Han J, Sun B. Construction and Evaluation of Molecular Models: Guide and Design of Novel SE Inhibitors. Acs Medicinal Chemistry Letters. 11: 1152-1159. PMID 32550995 DOI: 10.1021/acsmedchemlett.0c00017   
2020 Zhang L, Lai F, Chen X, Xiao Z. Identification of potential indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors by an FBG-based 3D QSAR pharmacophore model. Journal of Molecular Graphics & Modelling. 99: 107628. PMID 32387857 DOI: 10.1016/j.jmgm.2020.107628   
2020 S Hifnawy M, Hassan HM, Mohammed R, M Fouda M, Sayed AM, A Hamed A, F AbouZid S, Rateb ME, Alhadrami HA, Abdelmohsen UR. Induction of Antibacterial Metabolites by Co-Cultivation of Two Red-Sea-Sponge-Associated Actinomycetes sp. UR56 and sp. EG49. Marine Drugs. 18. PMID 32380771 DOI: 10.3390/md18050243   
2020 Wang X, Yang Y, Gao Y, Niu X. Discovery of the Novel Inhibitor Against New Delhi Metallo-β-Lactamase Based on Virtual Screening and Molecular Modelling. International Journal of Molecular Sciences. 21. PMID 32443639 DOI: 10.3390/ijms21103567   
2020 Gonçalves DS, de S Melo SM, Jacomini AP, J V da Silva M, Pianoski KE, Ames FQ, Aguiar RP, Oliveira AF, Volpato H, Bidóia DL, Nakamura CV, Bersani-Amado CA, Back DF, Moura S, Paula FR, et al. Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. Bioorganic & Medicinal Chemistry. 28: 115549. PMID 32503692 DOI: 10.1016/j.bmc.2020.115549   
2020 Gütschow M, Küppers J, Benkel T, Annala S, Kimura K, Reinelt L, Fleischmann BK, Kostenis E. Tetrahydroimidazo[1,2-a]pyrazine Derivatives: Synthesis and Evaluation As Gαq-Protein Ligands. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 32428383 DOI: 10.1002/chem.202001446   
2020 Minond D. Novel Approaches and Challenges of Discovery of Exosite Modulators of a Disintegrin and Metalloprotease 10. Frontiers in Molecular Biosciences. 7: 75. PMID 32435655 DOI: 10.3389/fmolb.2020.00075   
2020 Newton AS, Faver JC, Micevic G, Muthusamy V, Kudalkar SN, Bertoletti N, Anderson KS, Bosenberg MW, Jorgensen WL. Structure-Guided Identification of DNMT3B Inhibitors. Acs Medicinal Chemistry Letters. 11: 971-976. PMID 32435413 DOI: 10.1021/acsmedchemlett.0c00011   
2020 Zhao W, Xiong M, Yuan X, Li M, Sun H, Xu Y. In Silico Screening-based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-validation Study of Molecular Docking and Experimental Testing. Journal of Chemical Information and Modeling. PMID 32459092 DOI: 10.1021/acs.jcim.0c00171   
2020 Lolak N, Akocak S, Türkeş C, Taslimi P, Işık M, Beydemir Ş, Gülçin İ, Durgun M. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorganic Chemistry. 100: 103897. PMID 32413628 DOI: 10.1016/j.bioorg.2020.103897   
2020 Avci A, Taşci H, Kandemir Ü, Can ÖD, Gökhan-Kelekçi N, Tozkoparan B. Synthesis, characterization, and in vivo pharmacological evaluation of novel mannich bases derived from 1,2,4-triazole containing a naproxen moiety. Bioorganic Chemistry. 100: 103892. PMID 32388433 DOI: 10.1016/j.bioorg.2020.103892   
2020 Kim JH, Jang DH, Lee KW, Kim KD, Shah AB, Zhumanova K, Park KH. Tyrosinase Inhibition and Kinetic Details of Puerol A Having But-2-Enolide Structure from . Molecules (Basel, Switzerland). 25. PMID 32443441 DOI: 10.3390/molecules25102344   
2020 Gehling VS, McGrath JP, Duplessis M, Khanna A, Brucelle F, Vaswani RG, Côté A, Stuckey J, Watson V, Cummings RT, Balasubramanian S, Iyer P, Sawant P, Good AC, Albrecht BK, et al. Design and Synthesis of Styrenylcyclopropylamine LSD1 Inhibitors. Acs Medicinal Chemistry Letters. 11: 1213-1220. PMID 32551003 DOI: 10.1021/acsmedchemlett.0c00060   
2020 Nan J, Zhang S, Zhan P, Jiang L. Evaluation of Bronopol and Disulfiram as Potential Liberibacter asiaticus Inosine 5'-Monophosphate Dehydrogenase Inhibitors by Using Molecular Docking and Enzyme Kinetic. Molecules (Basel, Switzerland). 25. PMID 32423116 DOI: 10.3390/molecules25102313   
2020 Nan J, Zhang S, Zhan P, Jiang L. Evaluation of Bronopol and Disulfiram as Potential Liberibacter asiaticus Inosine 5'-Monophosphate Dehydrogenase Inhibitors by Using Molecular Docking and Enzyme Kinetic. Molecules (Basel, Switzerland). 25. PMID 32423116 DOI: 10.3390/molecules25102313   
2020 Kung PP, Bingham P, Burke BJ, Chen Q, Cheng X, Deng YL, Dou D, Feng J, Gallego GM, Gehring MR, Grant SK, Greasley S, Harris AR, Maegley KA, Meier J, et al. Characterization of Specific -α-Acetyltransferase 50 (Naa50) Inhibitors Identified Using a DNA Encoded Library. Acs Medicinal Chemistry Letters. 11: 1175-1184. PMID 32550998 DOI: 10.1021/acsmedchemlett.0c00029   
2020 Kosaka M, Zhang D, Wong S, Yan Z. NADPH-Independent Inactivation of CYP2B6 and NADPH-dependent Inactivation of CYP3A4/5 by Pyrrolobenzodiazepine Dimer (PBD) and Potential Implication for Assessing Covalent Modulators for Time-dependent Inhibition. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 32482757 DOI: 10.1124/dmd.120.090878   
2020 Zhou B, Li H, Cui Z, Li D, Geng H, Gao J, Zhou L. Simple analogues of natural product chelerythrine: Discovery of a novel anticholinesterase 2-phenylisoquinolin-2-ium scaffold with excellent potency against acetylcholinesterase. European Journal of Medicinal Chemistry. 200: 112415. PMID 32454229 DOI: 10.1016/j.ejmech.2020.112415   
2020 Xu D, Xue G, Peng B, Feng Z, Lu H, Gong L. High-Throughput Docking and Molecular Dynamics Simulations towards the Identification of Potential Inhibitors against Human Coagulation Factor XIIa. Computational and Mathematical Methods in Medicine. 2020: 2852051. PMID 32549905 DOI: 10.1155/2020/2852051   
2020 Era B, Delogu GL, Pintus F, Fais A, Gatto G, Uriarte E, Borges F, Kumar A, Matos MJ. Looking for new xanthine oxidase inhibitors: 3-Phenylcoumarins versus 2-phenylbenzofurans. International Journal of Biological Macromolecules. PMID 32574739 DOI: 10.1016/j.ijbiomac.2020.06.152   
2020 Caselli E, Fini F, Introvigne ML, Stucchii M, Taracila MA, Fish E, Smolen K, Rather PN, Powers RA, Wallar BJ, Bonomo RA, Prati F. 1,2,3-Triazolylmethaneboronate: a Structure Activity Relationship Study of a New Class of β-Lactamase Inhibitors against Acinetobacter baumannii Cephalosporinase (ADC-7). Acs Infectious Diseases. PMID 32502340 DOI: 10.1021/acsinfecdis.0c00254   
2020 Ferraro F, Cabrera MA, Álvarez GI, Corvo I. Drug Targets: Screening for Small Molecules that Inhibit Fasciola hepatica Enzymes. Methods in Molecular Biology (Clifton, N.J.). 2137: 221-231. PMID 32399933 DOI: 10.1007/978-1-0716-0475-5_17   
2020 Taha M, Uddin N, Ali M, Anouar EH, Rahim F, Khan G, Farooq RK, Gollapalli M, Iqbal N, Farooq M, Khan KM. Inhibition potential of phenyl linked benzimidazole-triazolothiadiazole modular hybrids against β-glucuronidase and their interactions thereof. International Journal of Biological Macromolecules. PMID 32512086 DOI: 10.1016/j.ijbiomac.2020.06.006