Anders Skov Kristensen, Ph.D. - Publications

Medicinal Chemistry University of Copenhagen, København, Denmark 
Glutamate receptors, SLC6 transporters

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Andersen J, Ladefoged LK, Kristensen TN, Munro L, Grouleff J, Stuhr-Hansen N, Kristensen AS, Schiøtt B, Strømgaard K. Interrogating the molecular basis for substrate recognition in serotonin and dopamine transporters with high-affinity substrate-based bivalent ligands. Acs Chemical Neuroscience. PMID 27425420 DOI: 10.1021/acschemneuro.6b00164  0.32
2015 Larsen MA, Plenge P, Andersen J, Eildal JN, Kristensen AS, Bøgesø KP, Gether U, Strømgaard K, Bang-Andersen B, Loland CJ. Structure-activity relationship studies of citalopram derivatives: examining substituents conferring selectivity for the allosteric site in the serotonin transporter. British Journal of Pharmacology. PMID 26699847 DOI: 10.1111/bph.13411  0.56
2015 Kristensen AS, Hansen KB, Naur P, Olsen L, Kurtkaya NL, Dravid SM, Kvist T, Yi F, Pohlsgaard J, Clausen RP, Gajhede M, Kastrup JS, Traynelis SF. Pharmacology and Structural Analysis of Ligand Binding to the Orthosteric Site of Glutamate-Like GluD2 Receptors. Molecular Pharmacology. PMID 26661043 DOI: 10.1124/mol.115.100909  0.56
2015 Andersen J, Ringsted KB, Bang-Andersen B, Strømgaard K, Kristensen AS. Binding site residues control inhibitor selectivity in the human norepinephrine transporter but not in the human dopamine transporter. Scientific Reports. 5: 15650. PMID 26503701 DOI: 10.1038/srep15650  0.56
2015 Andersen J, Ladefoged LK, Wang D, Kristensen TN, Bang-Andersen B, Kristensen AS, Schiøtt B, Strømgaard K. Binding of the Multimodal Antidepressant Drug Vortioxetine to the Human Serotonin Transporter. Acs Chemical Neuroscience. PMID 26389667 DOI: 10.1021/acschemneuro.5b00225  0.56
2015 Söderhielm PC, Andersen J, Munro L, Nielsen AT, Kristensen AS. Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry. Molecular Pharmacology. 88: 676-88. PMID 26174773 DOI: 10.1124/mol.115.099911  0.56
2015 Rannversson H, Wilson P, Kristensen KB, Sinning S, Kristensen AS, Strømgaard K, Andersen J. Importance of the Extracellular Loop 4 in the Human Serotonin Transporter for Inhibitor Binding and Substrate Translocation. The Journal of Biological Chemistry. 290: 14582-94. PMID 25903124 DOI: 10.1074/jbc.M114.629071  0.56
2015 Nissen KB, Haugaard-Kedström LM, Wilbek TS, Nielsen LS, Åberg E, Kristensen AS, Bach A, Jemth P, Strømgaard K. Targeting protein-protein interactions with trimeric ligands: high affinity inhibitors of the MAGUK protein family. Plos One. 10: e0117668. PMID 25658767 DOI: 10.1371/journal.pone.0117668  0.56
2015 Poulsen MH, Andersen J, Christensen R, Hansen KB, Traynelis SF, Strømgaard K, Kristensen AS. Binding of ArgTX-636 in the NMDA receptor ion channel. Journal of Molecular Biology. 427: 176-89. PMID 24862283 DOI: 10.1016/j.jmb.2014.05.017  0.56
2014 Jørgensen L, Nielsen B, Pickering DS, Kristensen AS, Frydenvang K, Madsen U, Clausen RP. Analogues of 3-hydroxyisoxazole-containing glutamate receptor ligands based on the 3-hydroxypyrazole-moiety: design, synthesis and pharmacological characterization. Neurochemical Research. 39: 1895-905. PMID 24848194 DOI: 10.1007/s11064-014-1332-0  0.56
2014 Nørager NG, Poulsen MH, Jensen AG, Jeppesen NS, Kristensen AS, Strømgaard K. Structure-activity relationship studies of N-methylated and N-hydroxylated spider polyamine toxins as inhibitors of ionotropic glutamate receptors. Journal of Medicinal Chemistry. 57: 4940-9. PMID 24824658 DOI: 10.1021/jm5004705  0.56
2014 Poulsen MH, Lucas S, Strømgaard K, Kristensen AS. Inhibition of AMPA receptors by polyamine toxins is regulated by agonist efficacy and stargazin. Neurochemical Research. 39: 1906-13. PMID 24557991 DOI: 10.1007/s11064-014-1258-6  0.56
2014 Andersen J, Stuhr-Hansen N, Zachariassen LG, Koldsø H, Schiøtt B, Strømgaard K, Kristensen AS. Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac). Molecular Pharmacology. 85: 703-14. PMID 24516100 DOI: 10.1124/mol.113.091249  0.56
2014 Sørensen L, Strømgaard K, Kristensen AS. Characterization of intracellular regions in the human serotonin transporter for phosphorylation sites. Acs Chemical Biology. 9: 935-44. PMID 24450286 DOI: 10.1021/cb4007198  0.56
2014 Poulsen MH, Lucas S, Strømgaard K, Kristensen AS. Evaluation of PhTX-74 as subtype-selective inhibitor of GluA2-containing AMPA receptors. Molecular Pharmacology. 85: 261-8. PMID 24220009 DOI: 10.1124/mol.113.089961  0.56
2013 Nørager NG, Jensen CB, Rathje M, Andersen J, Madsen KL, Kristensen AS, Strømgaard K. Development of potent fluorescent polyamine toxins and application in labeling of ionotropic glutamate receptors in hippocampal neurons. Acs Chemical Biology. 8: 2033-41. PMID 23838571 DOI: 10.1021/cb400272m  0.56
2013 Poulsen MH, Lucas S, Bach TB, Barslund AF, Wenzler C, Jensen CB, Kristensen AS, Strømgaard K. Structure-activity relationship studies of argiotoxins: selective and potent inhibitors of ionotropic glutamate receptors. Journal of Medicinal Chemistry. 56: 1171-81. PMID 23320429 DOI: 10.1021/jm301602d  0.56
2012 Lucas S, Poulsen MH, Nørager NG, Barslund AF, Bach TB, Kristensen AS, Strømgaard K. General synthesis of β-alanine-containing spider polyamine toxins and discovery of nephila polyamine toxins 1 and 8 as highly potent inhibitors of ionotropic glutamate receptors. Journal of Medicinal Chemistry. 55: 10297-301. PMID 23092360 DOI: 10.1021/jm301255m  0.56
2012 Sørensen L, Andersen J, Thomsen M, Hansen SM, Zhao X, Sandelin A, Strømgaard K, Kristensen AS. Interaction of antidepressants with the serotonin and norepinephrine transporters: mutational studies of the S1 substrate binding pocket. The Journal of Biological Chemistry. 287: 43694-707. PMID 23086945 DOI: 10.1074/jbc.M112.342212  0.56
2012 Strømgaard K, Kristensen AS. A heteromeric snake toxin and the molecular details of pain perception. Angewandte Chemie (International Ed. in English). 51: 4009-11. PMID 22422721 DOI: 10.1002/anie.201200340  0.56
2012 Bach A, Clausen BH, Møller M, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K. A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proceedings of the National Academy of Sciences of the United States of America. 109: 3317-22. PMID 22343531 DOI: 10.1073/pnas.1113761109  0.56
2011 Kristensen AS, Andersen J, Jørgensen TN, Sørensen L, Eriksen J, Loland CJ, Strømgaard K, Gether U. SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacological Reviews. 63: 585-640. PMID 21752877 DOI: 10.1124/pr.108.000869  0.56
2011 Andersen J, Stuhr-Hansen N, Zachariassen L, Toubro S, Hansen SM, Eildal JN, Bond AD, Bøgesø KP, Bang-Andersen B, Kristensen AS, Strømgaard K. Molecular determinants for selective recognition of antidepressants in the human serotonin and norepinephrine transporters. Proceedings of the National Academy of Sciences of the United States of America. 108: 12137-42. PMID 21730142 DOI: 10.1073/pnas.1103060108  0.56
2011 Kristensen AS, Jenkins MA, Banke TG, Schousboe A, Makino Y, Johnson RC, Huganir R, Traynelis SF. Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating. Nature Neuroscience. 14: 727-35. PMID 21516102 DOI: 10.1038/nn.2804  0.56
2011 Barslund AF, Poulsen MH, Bach TB, Lucas S, Kristensen AS, Strømgaard K. Solid-phase synthesis and biological evaluation of Joro spider toxin-4 from Nephila clavata. Journal of Natural Products. 74: 483-6. PMID 21188966 DOI: 10.1021/np100746w  0.56
2010 Frølund S, Bella A, Kristensen AS, Ziegler HL, Witt M, Olsen CA, Strømgaard K, Franzyk H, Jaroszewski JW. Assessment of structurally diverse philanthotoxin analogues for inhibitory activity on ionotropic glutamate receptor subtypes: discovery of nanomolar, nonselective, and use-dependent antagonists. Journal of Medicinal Chemistry. 53: 7441-51. PMID 20873775 DOI: 10.1021/jm100886h  0.56
2010 Chi CN, Bach A, Gottschalk M, Kristensen AS, Strømgaard K, Jemth P. Deciphering the kinetic binding mechanism of dimeric ligands using a potent plasma-stable dimeric inhibitor of postsynaptic density protein-95 as an example. The Journal of Biological Chemistry. 285: 28252-60. PMID 20576616 DOI: 10.1074/jbc.M110.124040  0.56
2010 Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS. Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter. The Journal of Biological Chemistry. 285: 2051-63. PMID 19892699 DOI: 10.1074/jbc.M109.072587  0.56
2009 Bach A, Chi CN, Pang GF, Olsen L, Kristensen AS, Jemth P, Strømgaard K. Design and synthesis of highly potent and plasma-stable dimeric inhibitors of the PSD-95-NMDA receptor interaction. Angewandte Chemie (International Ed. in English). 48: 9685-9. PMID 19937879 DOI: 10.1002/anie.200904741  0.56
2009 Clausen RP, Naur P, Kristensen AS, Greenwood JR, Strange M, Bräuner-Osborne H, Jensen AA, Nielsen AS, Geneser U, Ringgaard LM, Nielsen B, Pickering DS, Brehm L, Gajhede M, Krogsgaard-Larsen P, et al. The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization. Journal of Medicinal Chemistry. 52: 4911-22. PMID 19588945 DOI: 10.1021/jm900565c  0.56
2009 Andersen J, Kristensen AS, Bang-Andersen B, Strømgaard K. Recent advances in the understanding of the interaction of antidepressant drugs with serotonin and norepinephrine transporters. Chemical Communications (Cambridge, England). 3677-92. PMID 19557250 DOI: 10.1039/b903035m  0.56
2009 Gottschalk M, Bach A, Hansen JL, Krogsgaard-Larsen P, Kristensen AS, Strømgaard K. Detecting protein-protein interactions in living cells: development of a bioluminescence resonance energy transfer assay to evaluate the PSD-95/NMDA receptor interaction. Neurochemical Research. 34: 1729-37. PMID 19495967 DOI: 10.1007/s11064-009-9998-4  0.56
2009 Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS. Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants. The Journal of Biological Chemistry. 284: 10276-84. PMID 19213730 DOI: 10.1074/jbc.M806907200  0.36
2009 Hansen KB, Naur P, Kurtkaya NL, Kristensen AS, Gajhede M, Kastrup JS, Traynelis SF. Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 907-17. PMID 19176800 DOI: 10.1523/JNEUROSCI.4081-08.2009  0.56
2009 Nelson JK, Frølund SU, Tikhonov DB, Kristensen AS, Strømgaard K. Synthesis and biological activity of argiotoxin 636 and analogues: selective antagonists for ionotropic glutamate receptors. Angewandte Chemie (International Ed. in English). 48: 3087-91. PMID 19152392 DOI: 10.1002/anie.200805426  0.56
2008 Eildal JN, Andersen J, Kristensen AS, Jørgensen AM, Bang-Andersen B, Jørgensen M, Strømgaard K. From the selective serotonin transporter inhibitor citalopram to the selective norepinephrine transporter inhibitor talopram: synthesis and structure-activity relationship studies. Journal of Medicinal Chemistry. 51: 3045-8. PMID 18429609 DOI: 10.1021/jm701602g  0.56
2007 Naur P, Hansen KB, Kristensen AS, Dravid SM, Pickering DS, Olsen L, Vestergaard B, Egebjerg J, Gajhede M, Traynelis SF, Kastrup JS. Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proceedings of the National Academy of Sciences of the United States of America. 104: 14116-21. PMID 17715062 DOI: 10.1073/pnas.0703718104  0.56
2007 Erreger K, Geballe MT, Kristensen A, Chen PE, Hansen KB, Lee CJ, Yuan H, Le P, Lyuboslavsky PN, Micale N, Jørgensen L, Clausen RP, Wyllie DJ, Snyder JP, Traynelis SF. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Molecular Pharmacology. 72: 907-20. PMID 17622578 DOI: 10.1124/mol.107.037333  0.56
2006 Kasper C, Pickering DS, Mirza O, Olsen L, Kristensen AS, Greenwood JR, Liljefors T, Schousboe A, Wätjen F, Gajhede M, Sigurskjold BW, Kastrup JS. The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)-glutamate and the antagonist (S)-NS1209. Journal of Molecular Biology. 357: 1184-201. PMID 16483599 DOI: 10.1016/j.jmb.2006.01.024  0.56
2006 Kristensen AS, Geballe MT, Snyder JP, Traynelis SF. Glutamate receptors: variation in structure-function coupling. Trends in Pharmacological Sciences. 27: 65-9. PMID 16406088 DOI: 10.1016/  0.56
2005 Kristensen AS, Traynelis SF. Neuroscience: an intrusive chaperone. Nature. 435: 1042-3. PMID 15973396 DOI: 10.1038/4351042a  0.56
2004 Valgeirsson J, Nielsen EO, Peters D, Mathiesen C, Kristensen AS, Madsen U. Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. Journal of Medicinal Chemistry. 47: 6948-57. PMID 15615543 DOI: 10.1021/jm030638w  0.56
2004 Lund TM, Christensen E, Kristensen AS, Schousboe A, Lund AM. On the neurotoxicity of glutaric, 3-hydroxyglutaric, and trans-glutaconic acids in glutaric acidemia type 1. Journal of Neuroscience Research. 77: 143-7. PMID 15197747 DOI: 10.1002/jnr.20136  0.56
2004 Kristensen AS, Larsen MB, Johnsen LB, Wiborg O. Mutational scanning of the human serotonin transporter reveals fast translocating serotonin transporter mutants. The European Journal of Neuroscience. 19: 1513-23. PMID 15066148 DOI: 10.1111/j.1460-9568.2004.03202.x  0.56
2003 Valgeirsson J, Nielsen EØ, Peters D, Varming T, Mathiesen C, Kristensen AS, Madsen U. 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. Journal of Medicinal Chemistry. 46: 5834-43. PMID 14667236 DOI: 10.1021/jm030428j  0.56
2003 Valgeirsson J, Christensen JK, Kristensen AS, Pickering DS, Nielsen B, Fischer CH, Bräuner-Osborne H, Nielsen EØ, Krogsgaard-Larsen P, Madsen U. Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues. Bioorganic & Medicinal Chemistry. 11: 4341-9. PMID 13129570 DOI: 10.1016/S0968-0896(03)00485-1  0.56
2003 Bjerrum EJ, Kristensen AS, Pickering DS, Greenwood JR, Nielsen B, Liljefors T, Schousboe A, Bräuner-Osborne H, Madsen U. Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). Journal of Medicinal Chemistry. 46: 2246-9. PMID 12747796 DOI: 10.1021/jm020588f  0.56
2002 White HS, Sarup A, Bolvig T, Kristensen AS, Petersen G, Nelson N, Pickering DS, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A. Correlation between anticonvulsant activity and inhibitory action on glial gamma-aminobutyric acid uptake of the highly selective mouse gamma-aminobutyric acid transporter 1 inhibitor 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and its N-alkylated analogs. The Journal of Pharmacology and Experimental Therapeutics. 302: 636-44. PMID 12130726 DOI: 10.1124/jpet.102.034819  0.56
2001 Campiani G, Morelli E, Nacci V, Fattorusso C, Ramunno A, Novellino E, Greenwood J, Liljefors T, Griffiths R, Sinclair C, Reavy H, Kristensen AS, Pickering DS, Schousboe A, Cagnotto A, et al. Characterization of the 1H-cyclopentapyrimidine-2,4(1H,3H)-dione derivative (S)-CPW399 as a novel, potent, and subtype-selective AMPA receptor full agonist with partial desensitization properties. Journal of Medicinal Chemistry. 44: 4501-4. PMID 11741469 DOI: 10.1021/jm015552m  0.56
2001 Mortensen OV, Kristensen AS, Wiborg O. Species-scanning mutagenesis of the serotonin transporter reveals residues essential in selective, high-affinity recognition of antidepressants. Journal of Neurochemistry. 79: 237-47. PMID 11677251 DOI: 10.1046/j.1471-4159.2001.00587.x  0.56
1999 Mortensen OV, Kristensen AS, Rudnick G, Wiborg O. Molecular cloning, expression and characterization of a bovine serotonin transporter. Brain Research. Molecular Brain Research. 71: 120-6. PMID 10407194 DOI: 10.1016/S0169-328X(99)00178-3  0.56
Show low-probability matches.