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Douwe D. Breimer - Publications

Affiliations: 
pharmacology Leiden University, Leiden, Netherlands 
Website:
http://www.leidenuniv.nl/professoren/show.php3-medewerker_id=468.htm

264 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

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Year Citation  Score
2008 Breimer DD. PK/PD modelling and beyond: impact on drug development. Pharmaceutical Research. 25: 2720-2. PMID 18810328 DOI: 10.1007/s11095-008-9717-x  1
2008 van Ree JM, Breimer DD. Pharmacology in The Netherlands: past, present and future. Trends in Pharmacological Sciences. 29: 167-9. PMID 18355928 DOI: 10.1016/j.tips.2008.01.009  1
2003 Gaillard PJ, de Boer AB, Breimer DD. Pharmacological investigations on lipopolysaccharide-induced permeability changes in the blood-brain barrier in vitro. Microvascular Research. 65: 24-31. PMID 12535868 DOI: 10.1016/S0026-2862(02)00009-2  1
2003 van der Sandt ICJ, De Boer AG, Breimer DD. Implications of P-glycoprotein for the Transport and Distribution of Drugs into the Brain Blood-Spinal Cord and Brain Barriers in Health and Disease. 63-72. DOI: 10.1016/B978-012639011-7/50011-5  1
2001 van der Sandt IC, Gaillard PJ, Voorwinden HH, de Boer AG, Breimer DD. P-glycoprotein inhibition leads to enhanced disruptive effects by anti-microtubule cytostatics at the in vitro blood-brain barrier. Pharmaceutical Research. 18: 587-92. PMID 11465412 DOI: 10.1023/A:1011016923346  1
2001 van der Sandt IC, Smolders R, Nabulsi L, Zuideveld KP, de Boer AG, Breimer DD. Active efflux of the 5-HT(1A) receptor agonist flesinoxan via P-glycoprotein at the blood-brain barrier. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 14: 81-6. PMID 11457654 DOI: 10.1016/S0928-0987(01)00150-6  1
2001 Gaillard PJ, van Der Meide PH, de Boer AG, Breimer DD. Glucocorticoid and type 1 interferon interactions at the blood-brain barrier: relevance for drug therapies for multiple sclerosis. Neuroreport. 12: 2189-93. PMID 11447332  1
2001 van der Sandt IC, Vos CM, Nabulsi L, Blom-Roosemalen MC, Voorwinden HH, de Boer AG, Breimer DD. Assessment of active transport of HIV protease inhibitors in various cell lines and the in vitro blood--brain barrier. Aids (London, England). 15: 483-91. PMID 11242145 DOI: 10.1097/00002030-200103090-00007  1
2001 Breimer DD. Future training needs in the pharmaceutical sciences: academia -- industry. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 12: 347-52. PMID 11231100 DOI: 10.1016/S0928-0987(01)00099-9  1
2001 Gaillard PJ, Voorwinden LH, Nielsen JL, Ivanov A, Atsumi R, Engman H, Ringbom C, de Boer AG, Breimer DD. Establishment and functional characterization of an in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 12: 215-22. PMID 11113640 DOI: 10.1016/S0928-0987(00)00123-8  1
2000 Gaillard PJ, van der Sandt IC, Voorwinden LH, Vu D, Nielsen JL, de Boer AG, Breimer DD. Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier. Pharmaceutical Research. 17: 1198-205. PMID 11145224  1
2000 de Lange EC, de Boer AG, Breimer DD. Methodological issues in microdialysis sampling for pharmacokinetic studies. Advanced Drug Delivery Reviews. 45: 125-48. PMID 11108971 DOI: 10.1016/S0169-409X(00)00107-1  1
2000 Grouls R, Korsten E, Ackerman E, Hellebrekers L, Van Zundert A, Breimer D. Diffusion of n-butyl-p-aminobenzoate (BAB), lidocaine and bupivacaine through the human dura-arachnoid mater in vitro European Journal of Pharmaceutical Sciences. 12: 125-131. PMID 11102740 DOI: 10.1016/S0928-0987(00)00147-0  1
2000 van der Sandt IC, Blom-Roosemalen MC, de Boer AG, Breimer DD. Specificity of doxorubicin versus rhodamine-123 in assessing P-glycoprotein functionality in the LLC-PK1, LLC-PK1:MDR1 and Caco-2 cell lines. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 11: 207-14. PMID 11042226 DOI: 10.1016/S0928-0987(00)00097-X  1
2000 Pereira VA, Auler JO, Carmona MJ, Mateus FH, Lanchote VL, Breimer DD, Santos SR. A micromethod for quantitation of debrisoquine and 4-hydroxydebrisoquine in urine by liquid chromatography. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 33: 509-14. PMID 10775881  1
2000 Breimer DD. An interview with a distinguished pharmaceutical scientist: Douwe D. Breimer--elected Foreign Associate Member of the Institute of Medicine of the National Academy of Sciences of the U.S.A. (1999). Pharmaceutical Research. 17: 1-6. PMID 10714600  1
2000 Wijnholds J, deLange EC, Scheffer GL, van den Berg DJ, Mol CA, van der Valk M, Schinkel AH, Scheper RJ, Breimer DD, Borst P. Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. The Journal of Clinical Investigation. 105: 279-85. PMID 10675353 DOI: 10.1172/JCI8267  1
1999 de Lange EC, de Boer BA, Breimer DD. Microdialysis for pharmacokinetic analysis of drug transport to the brain. Advanced Drug Delivery Reviews. 36: 211-227. PMID 10837717 DOI: 10.1016/S0169-409X(98)00089-1  1
1999 Hesselink MB, Smolders H, De Boer AG, Breimer DD, Danysz W. Modifications of the behavioral profile of non-competitive NMDA receptor antagonists, memantine, amantadine and (+)MK-801 after chronic administration. Behavioural Pharmacology. 10: 85-98. PMID 10780305  1
1999 Hesselink MB, De Boer AG, Breimer DD, Danysz W. Dopamine release in the prefrontal cortex in response to memantine following sub-chronic NMDA receptor blockade with memantine: a microdialysis study in rats. Journal of Neural Transmission (Vienna, Austria : 1996). 106: 803-18. PMID 10599863 DOI: 10.1007/s007020050201  1
1999 Breimer DD. Future challenges for drug delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 62: 3-6. PMID 10518628 DOI: 10.1016/S0168-3659(99)00060-7  1
1999 Hesselink MB, De Boer AG, Breimer DD, Danysz W. Adaptations of NMDA and dopamine D2, but not of muscarinic receptors following 14 days administration of uncompetitive NMDA receptor antagonists. Journal of Neural Transmission (Vienna, Austria : 1996). 106: 409-21. PMID 10443547 DOI: 10.1007/s007020050168  1
1999 Hesselink MB, Smolders H, Eilbacher B, De Boer AG, Breimer DD, Danysz W. The role of probenecid-sensitive organic acid transport in the pharmacokinetics of N-methyl-D-aspartate receptor antagonists acting at the glycine(B)-site: microdialysis and maximum electroshock seizures studies. The Journal of Pharmacology and Experimental Therapeutics. 290: 543-50. PMID 10411561  1
1999 Hesselink MB, De Boer BG, Breimer DD, Danysz W. Brain penetration and in vivo recovery of NMDA receptor antagonists amantadine and memantine: a quantitative microdialysis study. Pharmaceutical Research. 16: 637-42. PMID 10350004 DOI: 10.1023/A:1018856020583  1
1999 van Steveninck AL, van Berckel BN, Schoemaker RC, Breimer DD, van Gerven JM, Cohen AF. The sensitivity of pharmacodynamic tests for the central nervous system effects of drugs on the effects of sleep deprivation. Journal of Psychopharmacology (Oxford, England). 13: 10-7. PMID 10221355  1
1999 de Boer AG, Gaillard PJ, Breimer DD. The transference of results between blood-brain barrier cell culture systems. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 8: 1-4. PMID 10072472 DOI: 10.1016/S0928-0987(99)00003-2  1
1999 Jochemsen R, Laveille C, Breimer DD. Application of pharmacokinetic/pharmacodynamic modelling and population approaches to drug development International Journal of Pharmaceutical Medicine. 13: 243-251.  1
1998 Breimer DD. Future challenges for drug delivery research. Advanced Drug Delivery Reviews. 33: 265-268. PMID 10837666 DOI: 10.1016/S0169-409X(98)00034-9  1
1998 de Lange EC, de Bock G, Schinkel AH, de Boer AG, Breimer DD. BBB transport and P-glycoprotein functionality using MDR1A (-/-) and wild-type mice. Total brain versus microdialysis concentration profiles of rhodamine-123. Pharmaceutical Research. 15: 1657-65. PMID 9833984 DOI: 10.1023/A:1011988024295  1
1998 Breimer DD. [Transport of drugs across the blood-brain barrier]. Verhandelingen - Koninklijke Academie Voor Geneeskunde Van België. 60: 47-60; discussion 60. PMID 9646722  1
1998 de Boer AG, Breimer DD. Cytokines and blood-brain barrier permeability. Progress in Brain Research. 115: 425-51. PMID 9632945 DOI: 10.1016/S0079-6123(08)62045-2  1
1998 Desrayaud S, De Lange EC, Lemaire M, Bruelisauer A, De Boer AG, Breimer DD. Effect of the Mdr1a P-glycoprotein gene disruption on the tissue distribution of SDZ PSC 833, a multidrug resistance-reversing agent, in mice. The Journal of Pharmacology and Experimental Therapeutics. 285: 438-43. PMID 9580581  1
1998 Meijer OC, de Lange EC, Breimer DD, de Boer AG, Workel JO, de Kloet ER. Penetration of dexamethasone into brain glucocorticoid targets is enhanced in mdr1A P-glycoprotein knockout mice. Endocrinology. 139: 1789-93. PMID 9528963 DOI: 10.1210/endo.139.4.5917  1
1998 De Boer AB, De Lange EL, Van der Sandt IC, Breimer DD. Transporters and the blood-brain barrier (BBB). International Journal of Clinical Pharmacology and Therapeutics. 36: 14-5. PMID 9476143  1
1998 Breimer DD. Pharmacokinetics and metabolism in drug development: current and future strategies Pharmacochemistry Library. 29: 85-89. DOI: 10.1016/S0165-7208(98)80047-0  1
1997 Tanaka E, Breimer DD. In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease. Journal of Clinical Pharmacy and Therapeutics. 22: 237-49. PMID 9548204  1
1997 de Lange EC, Danhof M, de Boer AG, Breimer DD. Methodological considerations of intracerebral microdialysis in pharmacokinetic studies on drug transport across the blood-brain barrier. Brain Research. Brain Research Reviews. 25: 27-49. PMID 9370049 DOI: 10.1016/S0165-0173(97)00014-3  1
1997 Tuk B, Oberyé JJ, Pieters MS, Schoemaker RC, Kemp B, van Gerven J, Danhof M, Kamphuisen HA, Cohen AF, Breimer DD, Peck CC. Pharmacodynamics of temazepam in primary insomnia: assessment of the value of quantitative electroencephalography and saccadic eye movements in predicting improvement of sleep. Clinical Pharmacology and Therapeutics. 62: 444-52. PMID 9357396 DOI: 10.1016/S0009-9236(97)90123-5  1
1997 Mulders TM, Bergman DJ, Poll-The BT, Smit GP, Breimer DD, Mulder GJ, Duran M, Smeitink JA. Abnormal glutathione conjugation in patients with tyrosinaemia type I. Journal of Inherited Metabolic Disease. 20: 473-85. PMID 9266383 DOI: 10.1023/A:1005385009831  1
1997 Grouls RJ, Ackerman EW, Korsten HH, Hellebrekers LJ, Breimer DD. Partition coefficients (n-octanol/water) of N-butyl-p-aminobenzoate and other local anesthetics measured by reversed-phase high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Sciences and Applications. 694: 421-5. PMID 9252058 DOI: 10.1016/S0378-4347(97)00207-7  1
1997 Auler Júnior JO, Espada EB, Crivelli E, Quintavalle TB, Kurata A, Stolf NA, Issy AM, Paschoa OE, Danhof M, Breimer DD, Chamone DA, Santos SR. Diclofenac plasma protein binding: PK-PD modelling in cardiac patients submitted to cardiopulmonary bypass. Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas MéDicas E BiolóGicas / Sociedade Brasileira De BiofíSica ... [Et Al.]. 30: 369-74. PMID 9246235  1
1997 de Vries HE, Kuiper J, de Boer AG, Van Berkel TJ, Breimer DD. The blood-brain barrier in neuroinflammatory diseases. Pharmacological Reviews. 49: 143-55. PMID 9228664  1
1997 Breimer DD, Danhof M. Relevance of the application of pharmacokinetic-pharmacodynamic modelling concepts in drug development. The "wooden shoe' paradigm. Clinical Pharmacokinetics. 32: 259-67. PMID 9113436 DOI: 10.2165/00003088-199732040-00001  1
1997 Grouls RJ, Meert TF, Korsten HH, Hellebrekers LJ, Breimer DD. Epidural and intrathecal n-butyl-p-aminobenzoate solution in the rat. Comparison with bupivacaine. Anesthesiology. 86: 181-7. PMID 9009953 DOI: 10.1097/00000542-199701000-00022  1
1997 Touw DJ, Jacobs FAH, Brimicombe RW, Heijerman HGM, Bakker W, Breimer DD. Pharmacokinetics of aerosolized tobramycin in adult patients with cystic fibrosis Antimicrobial Agents and Chemotherapy. 41: 184-187. PMID 8980777  1
1997 De Boer AG, Breimer DD. Hepatic first-pass effect and controlled drug delivery following rectal administration Advanced Drug Delivery Reviews. 28: 229-237. DOI: 10.1016/S0169-409X(97)00074-4  1
1997 Gaillard PJ, De Boer AG, Breimer DD. Astrocytes protect the in vitro blood-brain barrier against endotoxin mediated breakdown, through a steroid mediated pathway Endothelium: Journal of Endothelial Cell Research. 5: 358-359.  1
1997 Touw DJ, Breimer DD. The cytochrome P450 enzyme system. A family with actions, reactions and interactions. Part 2 | Een familie met acties, reacties en interacties. Deel 2. Het cytochroom P450-enzymsysteem Pharmaceutisch Weekblad. 132: 996-1009.  1
1997 Touw DJ, Breimer DD. The cytochrome P450 enzyme system. A family with actions, reactions and interactions. Part 1 | Het cytochroom P450-enzymsysteem. Een familie met acties, reacties en interacties. Deel 1 Pharmaceutisch Weekblad. 132: 948-963.  1
1997 De Boer AG, Gaillard PJ, De Lange ECM, Breimer DD. In-vitro and in-vivo methods to assess drug transport to the brain Proceedings of the Controlled Release Society. 215-216.  1
1997 De Lange ECM, De Boer AG, Breimer DD. Monitoring in vivo blood-brain barrier drug transport: Cerebrospinal fluid sampling, the unit impulse response method and, with special reference, intracerebral microdialysis | Suivi in vivo du transport des medicaments au travers de la barriere hemato-encephalique prelevement du fluide cerebrospinal, methode de la reponse a l'impulsion unitaire, et consideration speciale sur la microdialyse intracerebrale a partir de comprimes presentant diferentes cinetiques de liberation S.T.P. Pharma Sciences. 7: 17-27.  1
1997 Breimer DD. Future challenges for drug delivery-research Proceedings of the Controlled Release Society. 1-2.  1
1996 Mathot RA, Wenden EM, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Partial agonism of the nonselective adenosine receptor agonist 8-butylaminoadenosine at the A1 receptor in vivo. The Journal of Pharmacology and Experimental Therapeutics. 279: 1439-46. PMID 8968369  1
1996 Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, et al. Evaluation of orally administered highly variable drugs and drug formulations Pharmaceutical Research. 13: 1590-1594. PMID 8956322 DOI: 10.1023/A:1016468018478  1
1996 Breimer DD. [Pharmacokinetics as the key to understanding drug actions]. Pharmazie in Unserer Zeit. 25: 192-3. PMID 8927632  1
1996 Breimer DD. An integrated pharmacokinetic and pharmacodynamic approach to controlled drug delivery. Journal of Drug Targeting. 3: 411-5. PMID 8863134 DOI: 10.3109/10611869609015961  1
1996 van Steveninck AL, Gieschke R, Schoemaker RC, Roncari G, Tuk B, Pieters MS, Breimer DD, Cohen AF. Pharmacokinetic and pharmacodynamic interactions of bretazenil and diazepam with alcohol. British Journal of Clinical Pharmacology. 41: 565-73. PMID 8799523  1
1996 Groen K, Breimer DD. Antipyrine, theophylline, and hexobarbital as in vivo P450 probe drugs. Methods in Enzymology. 272: 169-77. PMID 8791775  1
1996 Mathoôt RA, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Pharmacokinetic-haemodynamic relationships of 2-chloroadenosine at adenosine A1 and A2a receptors in vivo. British Journal of Pharmacology. 118: 369-77. PMID 8735640 DOI: 10.1111/j.1476-5381.1996.tb15412.x  1
1996 de Vries HE, Blom-Roosemalen MC, de Boer AG, van Berkel TJ, Breimer DD, Kuiper J. Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro. The Journal of Pharmacology and Experimental Therapeutics. 277: 1418-23. PMID 8667205  1
1996 de Vries HE, Blom-Roosemalen MC, van Oosten M, de Boer AG, van Berkel TJ, Breimer DD, Kuiper J. The influence of cytokines on the integrity of the blood-brain barrier in vitro. Journal of Neuroimmunology. 64: 37-43. PMID 8598388 DOI: 10.1016/0165-5728(95)00148-4  1
1996 De Boer AG, Breimer DD. Reconstitution of the blood-brain barrier in cell culture for studies of drug transport and metabolism Advanced Drug Delivery Reviews. 22: 251-264. DOI: 10.1016/S0169-409X(96)00421-8  1
1996 Verhoef JC, Breimer DD. Fifth International Symposium on Delivery and Targeting of Peptides, Proteins and Genes: Editorial Journal of Controlled Release. 41: 1. DOI: 10.1016/S0168-3659(96)90040-1  1
1996 Breimer LH, Breimer DD. The CED - Le DEC: Common European Doctorate, or Doctorate Europeen Commune or dissertations on the internet Scientometrics. 35: 347-353.  1
1995 Mulders TM, Keizer, Ouwerkerk J, van der Velde EA, Breimer DD, Mulder GJ. Effect of ifosfamide treatment on glutathione and glutathione conjugation activity in patients with advanced cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 1: 1525-36. PMID 9815953  1
1995 Grouls RJ, Machielsen E, Korsten HH, Hellebrekers LJ, Breimer DD, Ackerman EW. Capillary gas chromatographic method for the determination of n-butyl-p-aminobenzoate and lidocaine in plasma samples. Journal of Chromatography. B, Biomedical Applications. 673: 51-7. PMID 8925074 DOI: 10.1016/0378-4347(95)00237-D  1
1995 de Lange EC, Danhof M, Zurcher C, de Boer AG, Breimer DD. Repeated microdialysis perfusions: periprobe tissue reactions and BBB permeability. Brain Research. 702: 261-5. PMID 8846086 DOI: 10.1016/0006-8993(95)01184-X  1
1995 de Vries HE, Eppens EF, Prins M, Kuiper J, van Berkel TJ, de Boer AG, Breimer DD. Transport of a hydrophilic compound into the cerebrospinal fluid during experimental allergic encephalomyelitis and after lipopolysaccharide administration. Pharmaceutical Research. 12: 1932-6. PMID 8786968 DOI: 10.1023/A:1016291806357  1
1995 de Lange EC, de Vries JD, Zurcher C, Danhof M, de Boer AG, Breimer DD. The use of intracerebral microdialysis for the determination of pharmacokinetic profiles of anticancer drugs in tumor-bearing rat brain. Pharmaceutical Research. 12: 1924-31. PMID 8786967 DOI: 10.1023/A:1016239822287  1
1995 de Lange EC, Bouw MR, Mandema JW, Danhof M, de Boer AG, Breimer DD. Application of intracerebral microdialysis to study regional distribution kinetics of drugs in rat brain. British Journal of Pharmacology. 116: 2538-44. PMID 8581296  1
1995 de Vries HE, Hoogendoorn KH, van Dijk J, Zijlstra FJ, van Dam AM, Breimer DD, van Berkel TJ, de Boer AG, Kuiper J. Eicosanoid production by rat cerebral endothelial cells: stimulation by lipopolysaccharide, interleukin-1 and interleukin-6. Journal of Neuroimmunology. 59: 1-8. PMID 7797610 DOI: 10.1016/0165-5728(95)00009-Q  1
1995 de Lange EC, Hesselink MB, Danhof M, de Boer AG, Breimer DD. The use of intracerebral microdialysis to determine changes in blood-brain barrier transport characteristics. Pharmaceutical Research. 12: 129-33. PMID 7724474 DOI: 10.1023/A:1016207208406  1
1995 Mathôt RA, Van den Aarsen BC, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Pharmacokinetic-pharmacodynamic modelling of the cardiovascular effects of R- and S-N6-phenylisopropyladenosine in conscious normotensive rats. The Journal of Pharmacology and Experimental Therapeutics. 273: 405-14. PMID 7714796  1
1995 Mulders TM, Keizer HJ, Breimer DD, Mulder GJ. In vivo characterization and modulation of the glutathione/glutathione S-transferase system in cancer patients. Drug Metabolism Reviews. 27: 191-229. PMID 7641576 DOI: 10.3109/03602539509029823  1
1995 de Vries HE, Breedveld B, Kuiper J, de Boer AG, Van Berkel TJ, Breimer DD. High-density lipoprotein and cerebral endothelial cells in vitro: interactions and transport. Biochemical Pharmacology. 50: 271-3. PMID 7632172 DOI: 10.1016/0006-2952(95)00127-L  1
1995 Groen K, Breimer DD, Brouwer A, Schijff G, Jansen EJ, van Bezooijen CF. The influence of dietary restriction on the metabolism of theophylline and antipyrine in the ageing female BN/BiRij rat. The Journal of Pharmacology and Experimental Therapeutics. 274: 143-7. PMID 7616391  1
1995 Breimer LH, Breimer DD. A computer-based international 'thesis-line'? Trends in Biochemical Sciences. 20: 175-6. PMID 7610477 DOI: 10.1016/S0968-0004(00)89000-3  1
1995 Noach AB, Blom-Roosemalen MC, De Boer AG, Breimer DD. Absorption enhancement of a hydrophilic model compound by verapamil after rectal administration to rats. The Journal of Pharmacy and Pharmacology. 47: 466-8. PMID 7545750  1
1995 Breimer DD. Rate and time control in drug delivery Farmacevtski Vestnik. 46: 159-160.  1
1994 Moor AC, de Vries HE, de Boer AG, Breimer DD. The blood-brain barrier and multiple sclerosis. Biochemical Pharmacology. 47: 1717-24. PMID 8204088 DOI: 10.1016/0006-2952(94)90297-6  1
1994 van Steveninck AL, Schoemaker HC, den Hartigh J, Pieters MS, Breimer DD, Cohen AF. Effects of intravenous temazepam. II. A study of the long-term reproducibility of pharmacokinetics, pharmacodynamics, and concentration-effect parameters. Clinical Pharmacology and Therapeutics. 55: 546-55. PMID 8181199  1
1994 van Steveninck AL, Schoemaker HC, den Hartigh J, Rijnkels J, Pieters MS, Breimer DD, Cohen AF. Effects of intravenous temazepam. I. Saccadic eye movements and electroencephalogram after fast and slow infusion to pseudo steady state. Clinical Pharmacology and Therapeutics. 55: 535-45. PMID 8181198  1
1994 Masereeuw R, Jaehde U, Langemeijer MW, de Boer AG, Breimer DD. In vitro and in vivo transport of zidovudine (AZT) across the blood-brain barrier and the effect of transport inhibitors. Pharmaceutical Research. 11: 324-30. PMID 8165196 DOI: 10.1023/A:1018932213953  1
1994 Mathôt RA, van Schaick EA, Langemeijer MW, Soudijn W, Breimer DD, Ijzerman AP, Danhof M. Pharmacokinetic-pharmacodynamic relationship of the cardiovascular effects of adenosine A1 receptor agonist N6-cyclopentyladenosine in the rat. The Journal of Pharmacology and Experimental Therapeutics. 268: 616-24. PMID 8113972  1
1994 Groen K, Breimer DD, Jansen EJ, van Bezooijen CF. The influence of aging on the metabolism of simultaneously administered hexobarbital enantiomers and antipyrine before and after phenobarbital induction in male rats: a longitudinal study. The Journal of Pharmacology and Experimental Therapeutics. 268: 531-6. PMID 8113964  1
1994 Jaehde U, Masereeuw R, De Boer AG, Fricker G, Nagelkerke JF, Vonderscher J, Breimer DD. Quantification and visualization of the transport of octreotide, a somatostatin analogue, across monolayers of cerebrovascular endothelial cells. Pharmaceutical Research. 11: 442-8. PMID 8008714 DOI: 10.1023/A:1018929508018  1
1994 de Vries HE, Moor AC, Blom-Roosemalen MC, de Boer AG, Breimer DD, van Berkel TJ, Kuiper J. Lymphocyte adhesion to brain capillary endothelial cells in vitro. Journal of Neuroimmunology. 52: 1-8. PMID 7911476 DOI: 10.1016/0165-5728(94)90155-4  1
1994 de Lange ECM, Danhof M, de Boer AG, Breimer DD. Critical factors of intracerebral microdialysis as a technique to determined the pharmacokinetics of drugs in rat brain Brain Research. 666: 1-8. PMID 7889356 DOI: 10.1016/0006-8993(94)90276-3  1
1994 De Boer AG, Breimer DD. The blood-brain barrier: clinical implications for drug delivery to the brain. Journal of the Royal College of Physicians of London. 28: 502-6. PMID 7884704  1
1994 Sakai M, Noach AB, Blom-Roosemalen MC, de Boer AG, Breimer DD. Absorption enhancement of hydrophilic compounds by verapamil in Caco-2 cell monolayers. Biochemical Pharmacology. 48: 1199-210. PMID 7524505 DOI: 10.1016/0006-2952(94)90157-0  1
1994 Noach AB, Sakai M, Blom-Roosemalen MC, de Jonge HR, de Boer AG, Breimer DD. Effect of anisotonic conditions on the transport of hydrophilic model compounds across monolayers of human colonic cell lines. The Journal of Pharmacology and Experimental Therapeutics. 270: 1373-80. PMID 7523659  1
1994 de Boer AG, de Vries HE, de Lange ECM, Danhof M, Kuiper J, Breimer DD. Drug transport to the brain: in vitro versus in vivo approaches Journal of Controlled Release. 28: 259-263. DOI: 10.1016/0168-3659(94)90173-2  1
1994 Breimer DD, Verhoef JC. Guest editorial Journal of Controlled Release. 29: v.  1
1993 Van Bree JB, De Boer AG, Danhof M, Breimer DD. Drug transport across the blood-brain barrier. III. Mechanisms and methods to improve drug delivery to the central nervous system. Pharmacy World & Science : Pws. 15: 2-9. PMID 8485503 DOI: 10.1007/BF02116163  1
1993 Soons PA, Mulders TM, Uchida E, Schoemaker HC, Cohen AF, Breimer DD. Stereoselective pharmacokinetics of oral felodipine and nitrendipine in healthy subjects: correlation with nifedipine pharmacokinetics. European Journal of Clinical Pharmacology. 44: 163-9. PMID 8453961 DOI: 10.1007/BF00315475  1
1993 Soons PA, Cohen AF, Breimer DD. Comparative effects of felodipine, nitrendipine and nifedipine in healthy subjects: concentration-effect relationships of racemic drugs and enantiomers. European Journal of Clinical Pharmacology. 44: 113-20. PMID 8453956 DOI: 10.1007/BF00315467  1
1993 Cohen AF, Kroon R, Schoemaker HC, Breimer DD, Van Vliet-Verbeek A, Brandenburg HC. The bioavailability of digoxin from three oral formulations measured by a specific h.p.l.c. assay. British Journal of Clinical Pharmacology. 35: 136-42. PMID 8443031  1
1993 van Steveninck AL, Pieters MS, Schoemaker HC, Breimer DD, Cohen AF. CNS-related performance and haemodynamics of metoprolol-Oros and propranolol after single and 3 days dosing in healthy volunteers. British Journal of Clinical Pharmacology. 35: 114-20. PMID 8443028  1
1993 Mulders TM, Venizelos V, Schoemaker R, Cohen AF, Breimer DD, Mulder GJ. Characterization of glutathione conjugation in humans: stereoselectivity in plasma elimination pharmacokinetics and urinary excretion of (R)- and (S)-2-bromoisovalerylurea in healthy volunteers. Clinical Pharmacology and Therapeutics. 53: 49-58. PMID 8422741 DOI: 10.1038/clpt.1993.8  1
1993 Groen K, Horan MA, Roberts NA, Gulati RS, Miljkovic B, Jansen EJ, Paramsothy V, Breimer DD, van Bezooijen CF. The relationship between phenazone (antipyrine) metabolite formation and theophylline metabolism in healthy and frail elderly women. Clinical Pharmacokinetics. 25: 136-44. PMID 8403737 DOI: 10.2165/00003088-199325020-00006  1
1993 De Boer A, Kluft C, Kasper FJ, Kroon JM, Schoemaker HC, Breimer DD, Soons PA, Cohen AF. Interaction study between nifedipine and recombinant tissue-type plasminogen activator in healthy subjects. British Journal of Clinical Pharmacology. 36: 99-104. PMID 8398589  1
1993 de Lange EC, Danhof M, de Boer AG, Breimer DD. The use of intracerebral microdialysis to study blood-brain barrier transport in health, after modification and in disease. Advances in Experimental Medicine and Biology. 331: 257-62. PMID 8333341  1
1993 Mulders TM, van Ommen B, van Bladeren PJ, Breimer DD, Mulder GJ. Stereoselectivity of human liver and intestinal cytosolic fractions as well as purified human glutathione S-transferase isoenzymes towards 2-bromoisovalerylurea enantiomers. Biochemical Pharmacology. 46: 1775-80. PMID 8250963 DOI: 10.1016/0006-2952(93)90582-H  1
1993 Roos RA, Tijssen MA, van der Velde EA, Breimer DD. The influence of a standard meal on Sinemet CR absorption in patients with Parkinson's disease. Clinical Neurology and Neurosurgery. 95: 215-9. PMID 8242964 DOI: 10.1016/0303-8467(93)90126-2  1
1993 Van Rooij J, Schoemaker HC, Bruno R, Reinhoudt JF, Breimer DD, Cohen AF. Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine. British Journal of Clinical Pharmacology. 35: 661-3. PMID 8101096  1
1993 Breimer DD, Urquhart J. Nifedipine GITS. Lancet (London, England). 341: 306. PMID 8093939  1
1993 de Vries HE, Kuiper J, de Boer AG, van Berkel TJ, Breimer DD. Characterization of the scavenger receptor on bovine cerebral endothelial cells in vitro. Journal of Neurochemistry. 61: 1813-21. PMID 7901334  1
1993 van Steveninck AL, Gieschke R, Schoemaker HC, Pieters MS, Kroon JM, Breimer DD, Cohen AF. Pharmacodynamic interactions of diazepam and intravenous alcohol at pseudo steady state. Psychopharmacology. 110: 471-8. PMID 7870919 DOI: 10.1007/BF02244655  1
1993 Hurni MA, Noach AB, Blom-Roosemalen MC, de Boer AG, Nagelkerke JF, Breimer DD. Permeability enhancement in Caco-2 cell monolayers by sodium salicylate and sodium taurodihydrofusidate: assessment of effect-reversibility and imaging of transepithelial transport routes by confocal laser scanning microscopy. The Journal of Pharmacology and Experimental Therapeutics. 267: 942-50. PMID 7504101  1
1993 Boeijinga JK, Kraaij CJ, Kleinbloesem CH, Cohen AF, Breimer DD. The influence of cilazapril on anticoagulation in hypertensive patients treated with coumarins Current Therapeutic Research. 54: 443-451. DOI: 10.1016/S0011-393X(05)80650-2  1
1993 Jaehde U, Goto T, de Boer AG, Breimer DD. Blood-brain barrier transport rate of quinoline antibacterials evaluated in cerebrovascular endothelial cell cultures European Journal of Pharmaceutical Sciences. 1: 49-55. DOI: 10.1016/0928-0987(93)90017-5  1
1993 Noach ABJ, Kurosaki Y, Blom-Roosemalen MCM, de Boer AG, Breimer DD. Cell-polarity dependent effect of chelation on the paracellular permeability of confluent caco-2 cell monolayers International Journal of Pharmaceutics. 90: 229-237. DOI: 10.1016/0378-5173(93)90195-L  1
1993 Van Steveninck AL, Van Berckel BNM, Schoemaker HC, Breimer DD, Cohen AF. Sensitivity of CNS performances tests to the effects of sleep deprivation British Journal of Clinical Pharmacology. 35: 551P.  1
1992 Stark H, Van Bree JBMM, De Boer AG, Jaehde U, Breimer DD. In vitro penetration of des-tyrosine1-D-phenylalanine3-β-casomorphin across the blood-brain barrier Peptides. 13: 47-51. PMID 1620656 DOI: 10.1016/0196-9781(92)90138-S  1
1992 de Boer A, Kluft C, Kroon JM, Kasper FJ, Schoemaker HC, Pruis J, Breimer DD, Soons PA, Emeis JJ, Cohen AF. Liver blood flow as a major determinant of the clearance of recombinant human tissue-type plasminogen activator. Thrombosis and Haemostasis. 67: 83-7. PMID 1615490  1
1992 Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M. Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers. Clinical Pharmacology and Therapeutics. 51: 715-28. PMID 1611810  1
1992 Venizelos V, Irth H, Tjaden UR, van der Greef J, Breimer DD, Mulders TM, Mulder GJ. Enantioselective determination of R- and S-(alpha-bromoisovaleryl)urea in plasma using high-performance liquid chromatography after solid-phase extraction. Journal of Chromatography. 573: 259-64. PMID 1601958 DOI: 10.1016/0378-4347(92)80127-C  1
1992 Soons PA, van den Berg G, Danhof M, van Brummelen P, Jansen JBMJ, Lamers CBHW, Breimer DD. Influence of single- and multiple-dose omeprazole treatment on nifedipine pharmacokinetics and effects in healthy subjects European Journal of Clinical Pharmacology. 42: 319-324. PMID 1577051 DOI: 10.1007/BF00266355  1
1992 Soons PA, Schoemaker HC, Cohen AF, Breimer DD. Intraindividual variability in nifedipine pharmacokinetics and effects in healthy subjects. Journal of Clinical Pharmacology. 32: 324-31. PMID 1569235  1
1992 Soons PA, Ankermann T, Breimer DD, Kirch W. Stereoselective pharmacokinetics of oral nitrendipine in elderly hypertensive patients with normal and impaired renal function European Journal of Clinical Pharmacology. 42: 423-427. PMID 1516607 DOI: 10.1007/BF00280129  1
1992 de Boer A, Kroon JM, Kroon C, van Vliet A, Schoemaker HC, Breimer DD, Donoghue S, Cohen AF. Pronounced effects of the combination of a new thromboxane antagonist (GR32191) and heparin on bleeding time in man. Thrombosis and Haemostasis. 68: 24-9. PMID 1514168  1
1992 Van Bree JB, De Boer AG, Danhof M, Breimer DD. Drug transport across the blood-brain barrier. II. Experimental techniques to study drug transport. Pharmaceutisch Weekblad. Scientific Edition. 14: 338-48. PMID 1475172 DOI: 10.1007/BF01970169  1
1992 Jaehde U, Langemeijer MW, de Boer AG, Breimer DD. Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats. The Journal of Pharmacology and Experimental Therapeutics. 263: 1140-6. PMID 1469626  1
1992 Van Bree JB, De Boer AG, Danhof M, Breimer DD. Drug transport across the blood--brain barrier. I. Anatomical and physiological aspects. Pharmaceutisch Weekblad. Scientific Edition. 14: 305-10. PMID 1437514 DOI: 10.1007/BF01977618  1
1992 van Steveninck AL, Verver S, Schoemaker HC, Pieters MS, Kroon R, Breimer DD, Cohen AF. Effects of temazepam on saccadic eye movements: concentration-effect relationships in individual volunteers. Clinical Pharmacology and Therapeutics. 52: 402-8. PMID 1424412  1
1992 Lehr CM, Bouwstra JA, Kok W, De Boer AG, Tukker JJ, Verhoef JC, Breimer DD, Junginger HE. Effects of the mucoadhesive polymer polycarbophil on the intestinal absorption of a peptide drug in the rat. The Journal of Pharmacy and Pharmacology. 44: 402-7. PMID 1359054 DOI: 10.1111/j.2042-7158.1992.tb03633.x  1
1992 Groen K, Breimer DD, van Bezooijen CF. Metabolism of simultaneously administered antipyrine and theophylline in male BN/BiRij rats before and after induction with 3-methylcholanthrene. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 20: 502-6. PMID 1356725  1
1992 Soons PA, Grib C, Breimer DD, Kirch W. Effects of acute febrile infectious diseases on the oral pharmacokinetics and effects of nitrendipine enantiomers and of bisoprolol. Clinical Pharmacokinetics. 23: 238-48. PMID 1355019 DOI: 10.2165/00003088-199223030-00006  1
1992 de Boer A, Kluft C, Dooijewaard G, Kasper FJ, Kroon JM, Breimer DD, Stiekema JC, Cohen AF. Influence of heparin and a low molecular weight heparinoid on specific endogenous and exogenous fibrinolytic factors during rest and exercise. Thrombosis and Haemostasis. 68: 550-5. PMID 1280862  1
1992 de Boer AG, van Hoogdalem EJ, Breimer DD. (D) Routes of delivery: Case studies. (4) Rate-controlled rectal peptide drug absorption enhancement Advanced Drug Delivery Reviews. 8: 237-251. DOI: 10.1016/0169-409X(92)90004-A  1
1992 Breimer DD. Pharmacokinetic and pharmacodynamic basis for peptide drug delivery system design Journal of Controlled Release. 21: 5-10. DOI: 10.1016/0168-3659(92)90003-A  1
1992 Breimer DD, Verhoef JC. Third International Symposium on Disposition and Delivery of Peptide Drugs: Guest editorial Journal of Controlled Release. 21: 3. DOI: 10.1016/0168-3659(92)90002-9  1
1991 Schellens JH, Soons PA, van der Wart JH, Hoevers JW, Breimer DD. Lack of pharmacokinetic interaction between nifedipine, sparteine and phenytoin in man. British Journal of Clinical Pharmacology. 31: 175-8. PMID 2049233 DOI: 10.1111/j.1365-2125.1991.tb05508.x  1
1991 van Bree JBMM, Heijligers-Feijen CD, de Boer AG, Danhof M, Breimer DD. Stereoselective Transport of Baclofen Across the Blood–Brain Barrier in Rats as Determined by the Unit Impulse Response Methodology Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 8: 259-262. PMID 2023878 DOI: 10.1023/A:1015812725011  1
1991 Breimer DD, Ariens EJ. Problems in medical ethics and registration of racemates [2] Nederlands Tijdschrift Voor Geneeskunde. 135: 487-488. PMID 2023658  1
1991 Van Bree JBMM, Van Nispen JW, Verhoef JC, Breimer DD. Development of specific antisera against 9-desglycinamide-8-arginine vasopressin by site-specific immunization Journal of Pharmaceutical Sciences. 80: 46-49. PMID 2013849 DOI: 10.1002/jps.2600800112  1
1991 Schellens JH, Ghabrial H, van der Wart HH, Bakker EN, Wilkinson GR, Breimer DD. Differential effects of quinidine on the disposition of nifedipine, sparteine, and mephenytoin in humans. Clinical Pharmacology and Therapeutics. 50: 520-8. PMID 1934865 DOI: 10.1038/clpt.1991.177  1
1991 Soons PA, Vogels BA, Roosemalen MC, Schoemaker HC, Uchida E, Edgar B, Lundahl J, Cohen AF, Breimer DD. Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans. Clinical Pharmacology and Therapeutics. 50: 394-403. PMID 1914375  1
1991 Dooijewaard G, De Boer A, Turion PNC, Cohen AF, Breimer DD, Kluft C. Physical exercise induces enhancement of urokinase-type plasminogen activator (u-PA) levels in plasma Thrombosis and Haemostasis. 65: 82-86. PMID 1902597  1
1991 Schellens JH, Van Haelst IM, Houston JB, Breimer DD. Nonlinear first-pass metabolism of nifedipine in healthy subjects. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 21: 547-55. PMID 1897253 DOI: 10.3109/00498259109039494  1
1991 Soons PA, Breimer DD. Stereoselective pharmacokinetics of oral and intravenous nitrendipine in healthy male subjects British Journal of Clinical Pharmacology. 32: 11-16. PMID 1888628  1
1991 van Hoogdalem EJ, de Boer AG, Breimer DD. Pharmacokinetics of Rectal Drug Administration, Part II: Clinical Applications of Peripherally Acting Drugs, and Conclusions Clinical Pharmacokinetics. 21: 110-128. PMID 1884566 DOI: 10.2165/00003088-199121020-00003  1
1991 Roosemalen MCM, Soons PA, Funaki T, Breimer DD. High-performance liquid chromatographic determination of the polar metabolites of nifedipine in plasma, blood and urine Journal of Chromatography B: Biomedical Sciences and Applications. 565: 516-522. PMID 1874901 DOI: 10.1016/0378-4347(91)80419-D  1
1991 Van Steveninck AL, Schoemaker HC, Pieters MSM, Kroon R, Breimer DD, Cohen AF. A comparison of the sensitivities of adaptive tracking, eye movement analysis, and visual analog lines to the effects of incremental doses of temazepam in healthy volunteers Clinical Pharmacology and Therapeutics. 50: 172-180. PMID 1868679  1
1991 Soons PA, De Boer A, Cohen AF, Breimer DD. Assessment of hepatic blood flow in healthy subjects by continuous infusion of indocyanine green British Journal of Clinical Pharmacology. 32: 697-704. PMID 1768562  1
1991 De Boer A, Stiekema JCJ, Danhof M, Van Dinther TG, Boeijinga JK, Cohen AF, Breimer DD. Studies of interaction of a low-molecular-weight heparinoid (Org 10172) with cloxacillin and ticarcillin in healthy male volunteers Antimicrobial Agents and Chemotherapy. 35: 2110-2115. PMID 1759835  1
1991 de Boer A, Stiekema JCJ, Danhof M, Moolenaar AJ, Breimer DD. Interaction of ORG 10172, a low molecular weight heparinoid, and digoxin in healthy volunteers European Journal of Clinical Pharmacology. 41: 245-250. PMID 1748141 DOI: 10.1007/BF00315437  1
1991 Soons PA, Schellens JH, Roosemalen MC, Breimer DD. Analysis of nifedipine and its pyridine metabolite dehydronifedipine in blood and plasma: review and improved high-performance liquid chromatographic methodology. Journal of Pharmaceutical and Biomedical Analysis. 9: 475-84. PMID 1747400 DOI: 10.1016/0731-7085(91)80249-9  1
1991 De Boer A, Danhof M, Cohen AF, Magnani HN, Breimer DD. Interaction study between Org 10172, a low molecular weight heparinoid, and acetylsalicylic acid in healthy male volunteers Thrombosis and Haemostasis. 66: 202-207. PMID 1722918  1
1991 van Hoogdalem EJ, de Boer AG, Breimer DD. Pharmacokinetics of Rectal Drug Administration, Part I: General Considerations and Clinical Applications of Centrally Acting Drugs Clinical Pharmacokinetics. 21: 11-26. PMID 1717195 DOI: 10.2165/00003088-199121010-00002  1
1991 De Boer A, Stiekema JC, Danhof M, Breimer DD. Influence of chlorthalidone on the pharmacokinetics and pharmacodynamics of Org 10172 (Lomoparan®), a low molecular weight heparinoid, in healthy volunteers Journal of Clinical Pharmacology. 31: 611-617. PMID 1716644  1
1991 De Boer A, Stiekema JCJ, Danhof M, Breimer DD. The influence of Org 10172, a low molecular weight heparinoid, on antipyrine metabolism and the effect of enzyme induction on the response to Org 10172 British Journal of Clinical Pharmacology. 32: 23-29. PMID 1716140  1
1991 Breimer DD. Status of absorption enhancers Pharmaceutisch Weekblad. 126: 1044-1045.  1
1990 Soons PA, Kroon JM, Breimer DD. Effects of single-dose and short-term oral nifedipine on indocyanine green clearance as assessed by spectrophotometry and high performance liquid chromatography Journal of Clinical Pharmacology. 30: 693-698. PMID 2401748  1
1990 Cohen AF, van Hall MA, van Harten J, Schoemaker RC, Johansson P, Breimer DD, Visser R, Edgar B. The influence of infusion rate on the hemodynamic effects of felodipine. Clinical Pharmacology and Therapeutics. 48: 309-17. PMID 2401128  1
1990 Levy G, Amidon GL, Benet LZ, Borchardt RT, Brouwer KR, Fung HL, Giacomini KM, Kroboth PD, Repta AJ, Robinson JR, Slattery JT, Lee VHL, Breimer D, Sezaki H. Academic pharmaceutics: The challenge of excellence Pharmaceutical Research. 7: 782-785. PMID 2395809 DOI: 10.1023/A:1015844411943  1
1990 Soons PA, Roosemalen MCM, Breimer DD. Enantioselective determination of felodipine and other chiral dihydropyridine calcium entry blockers in human plasma Journal of Chromatography B: Biomedical Sciences and Applications. 528: 343-356. PMID 2384574 DOI: 10.1016/S0378-4347(00)82393-2  1
1990 Schellens JH, van der Wart JH, Breimer DD. Relationship between mephenytoin oxidation polymorphism and phenytoin, methylphenytoin and phenobarbitone hydroxylation assessed in a phenotyped panel of healthy subjects. British Journal of Clinical Pharmacology. 29: 665-71. PMID 2378787 DOI: 10.1111/j.1365-2125.1990.tb03687.x  1
1990 van Bree JBMM, Tio S, de Boer AG, Verhoef JC, Breimer DD. Transport of Desglycinamide-Arginine Vasopressin Across the Blood–Brain Barrier in Rats as Evaluated by the Unit Impulse Response Methodology Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 293-298. PMID 2339105 DOI: 10.1023/A:1015838532048  1
1990 Van Hoogdalem EJ, Vermeij-Kerrs C, De Boer AG, Breimer DD. Topical effects of absorption enhancing agents on the rectal mucosa of rats in vivo Journal of Pharmaceutical Sciences. 79: 866-870. PMID 2280353  1
1990 Verhoef JC, Boddé HE, de Boer AG, Bouwstra JA, Junginger HE, Merkus FWHM, Breimer DD. Transport of peptide and protein drugs across biological membranes European Journal of Drug Metabolism and Pharmacokinetics. 15: 83-93. PMID 2200688 DOI: 10.1007/BF03190191  1
1990 de Boer AG, van Hoogdalem EJ, Breimer DD. Improvement of drug absorption through enhancers European Journal of Drug Metabolism and Pharmacokinetics. 15: 155-157. PMID 2200684 DOI: 10.1007/BF03190198  1
1990 Breimer DD, Schellens JH. A 'cocktail' strategy to assess in vivo oxidative drug metabolism in humans. Trends in Pharmacological Sciences. 11: 223-5. PMID 2200179 DOI: 10.1016/0165-6147(90)90245-4  1
1990 van Hoogdalem EJ, Heijligers-Feijen CD, Verhoef JC, de Boer AG, Breimer DD. Absorption Enhancement of Rectally Infused Insulin by Sodium Tauro-24,25-Dihydrofusidate (STDHF) in Rats Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 7: 180-183. PMID 2106676 DOI: 10.1023/A:1015837004307  1
1990 Stiekema JCJ, de Boer A, Danhof M, Kroon C, Broekmans AW, van Dinther TH, Voerman J, Breimer DD. Interaction of the combined medication with the new low-molecular-weight heparinoid lomoparan® (Org 10172) and acenocoumarol Pathophysiology of Haemostasis and Thrombosis. 20: 136-146. PMID 1696921 DOI: 10.1159/000216120  1
1990 De Boer AG, van Hoogdalem EJ, Heijligers-Feijen CD, Verhoef J, Breimer DD. Rectal absorption enhancement of peptide drugs Journal of Controlled Release. 13: 241-246. DOI: 10.1016/0168-3659(90)90014-K  1
1990 van Bree JBMM, de Boer AG, Verhoef J, Danhof M, Breimer DD. Peptide transport across the blood-brain barrier Journal of Controlled Release. 13: 175-184. DOI: 10.1016/0168-3659(90)90008-H  1
1990 Groen K, Jansen EJ, Brouwer A, Breimer DD, Van Bezooijen KFA. The influence of dietary restriction on P-450 mediated drug metabolism European Journal of Pharmacology. 183: 1574-1575. DOI: 10.1016/0014-2999(90)94737-I  1
1990 Pieters MSM, Van Steveninck AL, Schoemaker HC, Kroon JM, Cohen AF, Breimer DD. Hemodynamic and central nervous system effects of metoprolol oros and propranolol in healthy volunteers European Journal of Pharmacology. 183: 2396. DOI: 10.1016/0014-2999(90)93964-R  1
1990 De Boer A, Danhof M, Cohen AF, Magnani HN, Breimer DD. Interactions study of the low molecular weight heparinoid Org 10172 (lomoparan®) and acetylsalicylic acid in healthy male volunteers European Journal of Pharmacology. 183: 641. DOI: 10.1016/0014-2999(90)93567-A  1
1990 Van Steveninck AL, Kroon JM, Schoemaker HC, Pieters MSM, Breimer DD, Cohen AF. Differential sensitivity of three performance tests to the effects of temazepam in healthy volunteers European Journal of Pharmacology. 183: 594-595. DOI: 10.1016/0014-2999(90)93513-P  1
1990 Uchida E, Soons PA, De Boer A, Schoemaker HC, Breimer DD, Cohen AF. Effects of oral nifedipine and physical exercise on liver blood flow in healthy subjects European Journal of Pharmacology. 183: 1646. DOI: 10.1016/0014-2999(90)91935-5  1
1990 de Boer AG, van Biee JDMM, Breimer DD. Pharmaceutical stategies for improving the delivery of peptides to the brain European Journal of Pharmacology. 183: 1637-1638. DOI: 10.1016/0014-2999(90)91926-3  1
1990 van Bezooijen KFA, Groen K, Breimer DD. The influence of age on drug metabolism: in vivo and in vitro studies European Journal of Pharmacology. 183: 1629-1630. DOI: 10.1016/0014-2999(90)91917-Z  1
1990 De Boer AG, Van Brummelen P, Breimer DD, Schmidt RJP. Pharmacokinetics and pharmacodynamics of metoprolol following single and multiple oral administration in two osmotic delivery systems Tgo - Tijdschrift Voor Therapie Geneesmiddel En Onderzoek. 15: 12-S.  1
1990 De Boer AG, Breimer DD. Constant drug release with an oral drug delivery system: The OROS-system Tgo - Tijdschrift Voor Therapie Geneesmiddel En Onderzoek. 15: 2-S.  1
1990 Boeijinga JK, Aghina JCFM, Breimer DD. Diltiazem versus propranolol in borderline and mild hypertension. Efficacy and tolerance in a double-blind study Current Therapeutic Research - Clinical and Experimental. 47: 184-193.  1
1990 Breimer DD, Verhoef JC. The Second International Symposium on Disposition and Delivery of Peptide Drugs: Guest editorial Journal of Controlled Release. 13: iii.  1
1990 Van Hall M, Van Harten J, Schoemaker HC, Breimer DD, Cohen AF. A computerised pump system for the administration of individualised infusions to human subjects. A tool for the study of rate-dependent effects British Journal of Clinical Pharmacology. 29: 648P-649P.  1
1990 Funaki T, Soons PA, Guengerich FP, Breimer DD. Pharmacokinetics and metabolism of nifedipine and its metabolites in rats: in-vivo oxidative cleavage of a pyridine-carboxylic acid ester metabolite of nifedipine Journal of Pharmacobio-Dynamics. 13: s-60.  1
1990 Soons PA, Roosemalen MCM, Breimer DD. Stereoselective pharmacokinetics of oral and intravenous nitrendipine in healthy subjects European Journal of Pharmacology. 183: 2283-2284.  1
1990 De Boer A, Kroon JM, Kroon C, Van Vliet A, Breimer DD, Donoghue S, Cohen AF. Synergistic effect of a new thromboxane antagonist (GR32191) and heparin on bleeding time in healthy male volunteers British Journal of Clinical Pharmacology. 29: 599P.  1
1990 Soons PA, Uchida E, De Boer A, Schoemaker HC, Breimer DD, Cohen AF. Effects of exercise and i.v. propranolol on liver blood flow in healthy subjects, estimated with a continuous infusion of indocyanine green British Journal of Clinical Pharmacology. 29: 642P.  1
1989 van Hoogdalem EJ, Heijligers-Feijen CD, Mathôt RA, Wackwitz AT, van Bree JB, Verhoef JC, de Boer AG, Breimer DD. Rectal absorption enhancement of cefoxitin and desglycinamide arginine vasopressin by sodium tauro-24,25-dihydrofusidate in conscious rats. The Journal of Pharmacology and Experimental Therapeutics. 251: 741-4. PMID 2810123  1
1989 Van Hoogdalem EJ, De Best MA, De Boer AG, Breimer DD. Variable effects of laurocapram (Azone) on rectal cefoxitin absorption in rats Journal of Pharmaceutical Sciences. 78: 691-692. PMID 2778677  1
1989 Van Harten J, Van Brummelen P, Ooms P, Danhof M, Blauw GJ, Breimer DD. Variability in the pharmacokinetics of nisoldipine as caused by differences in liver blood flow response Journal of Clinical Pharmacology. 29: 714-721. PMID 2778091  1
1989 Te Koppele JM, Schipper C, Breimer DD, Mulder GJ. Stereoselectivity in the urinary excretion of the mercapturates of (R)- and (S-) α-bromoisovalerylurea in man British Journal of Clinical Pharmacology. 28: 151-154. PMID 2775620 DOI: 10.1111/j.1365-2125.1989.tb05407.x  1
1989 Van Harten J, Burggraaf J, Danhof M, Van Brummelen P, Breimer DD. The contribution of nisoldipine-induced changes in liver blood flow to its pharmacokinetics after oral administration British Journal of Clinical Pharmacology. 27: 581-586. PMID 2757881  1
1989 Van Bree JBMM, De Boer AG, Verhoef JC, Danhof M, Breimer DD. Transport of vasopressin fragments across the blood-brain barrier: In vitro studies using monolayer cultures of bovine brain endothelial cells Journal of Pharmacology and Experimental Therapeutics. 249: 901-905. PMID 2732952  1
1989 Schellens JH, van der Wart JH, Brugman M, Breimer DD. Influence of enzyme induction and inhibition on the oxidation of nifedipine, sparteine, mephenytoin and antipyrine in humans as assessed by a "cocktail" study design. The Journal of Pharmacology and Experimental Therapeutics. 249: 638-45. PMID 2724144  1
1989 Soons PA, De Boer AG, Van Brummelen P, Breimer DD. Oral absorption profile of nitrendipine in healthy subjects: A kinetic and dynamic study British Journal of Clinical Pharmacology. 27: 179-189. PMID 2713213  1
1989 van Harten J, Burggraaf J, van Brummelen P, Breimer DD. Influence of Renal Function on the Pharmacokinetics and Cardiovascular Effects of Nisoldipine After Single and Multiple Dosing Clinical Pharmacokinetics. 16: 55-64. PMID 2706880 DOI: 10.2165/00003088-198916010-00004  1
1989 van Bree JBMM, Baljet AV, van Geyt A, de Boer AG, Danhof M, Breimer DD. The unit impulse response procedure for the pharmacokinetic evaluation of drug entry into the central nervous system Journal of Pharmacokinetics and Biopharmaceutics. 17: 441-462. PMID 2614681 DOI: 10.1007/BF01061457  1
1989 Funaki T, Soons PA, Guenoerich FP, Breimer DD. In vivo oxidative cleavage of a pyridinecarboxylic acid ester metabolite of nifedipine Biochemical Pharmacology. 38: 4213-4216. PMID 2597191 DOI: 10.1016/0006-2952(89)90517-0  1
1989 Van Hoogdalem EJ, Wackwitz ATE, De Boer AG, Breimer DD. 3-Amino-1-hydroxypropylidene-1,1-diphosphonate (APD): A novel enhancer of rectal cefoxitin absorption in rats Journal of Pharmacy and Pharmacology. 41: 339-341. PMID 2569522  1
1989 van Hoogdalem EJ, Heijligers-Feijen CD, de Boer AG, Verhoef JC, Breimer DD. Rectal Absorption Enhancement of Des-Enkephalin-γ-Endorphin (DEγE) by Medium-Chain Glycerides and EDTA in Conscious Rats Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 6: 91-95. PMID 2524034 DOI: 10.1023/A:1015864022305  1
1989 Breimer DD, Schellens JH, Soons PA. Nifedipine: variability in its kinetics and metabolism in man. Pharmacology & Therapeutics. 44: 445-54. PMID 2519350 DOI: 10.1016/0163-7258(89)90010-7  1
1989 Schellens JH, Janssens AR, van der Wart JH, van der Velde EA, Breimer DD. Relationship between the metabolism of antipyrine, hexobarbital and theophylline in patients with liver disease as assessed by a 'cocktail' approach. European Journal of Clinical Investigation. 19: 472-9. PMID 2511024 DOI: 10.1111/j.1365-2362.1989.tb00262.x  1
1988 van Bree JB, de Boer AG, Danhof M, Verhoef JC, van Wimersma Greidanus TB, Breimer DD. Radioimmunoassay of desglycinamide-arginine vasopressin and its application in a pharmacokinetic study in the rat. Peptides. 9: 555-9. PMID 3420013 DOI: 10.1016/0196-9781(88)90163-5  1
1988 Schellens JH, Soons PA, Breimer DD. Lack of bimodality in nifedipine plasma kinetics in a large population of healthy subjects. Biochemical Pharmacology. 37: 2507-10. PMID 3390213 DOI: 10.1016/0006-2952(88)90238-9  1
1988 Joeres RP, Vermeulen NP, Breimer DD. Influence of the rate of hepatic portal vein infusion on hexobarbital pharmacokinetics in the rat. Pharmacology. 36: 210-6. PMID 3368506  1
1988 Burm AG, de Boer AG, van Kleef JW, Vermeulen NP, de Leede LG, Spierdijk J, Breimer DD. Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers. Biopharmaceutics & Drug Disposition. 9: 85-95. PMID 3342287  1
1988 Schellens JH, van der Wart HH, Hoevers JW, Breimer DD. Gas chromatographic determination of sparteine and 2- and 5-dehydrosparteine in plasma and urine. Journal of Chromatography. 431: 203-9. PMID 3235532 DOI: 10.1016/S0378-4347(00)83086-8  1
1988 Schellens JH, van der Wart JH, Danhof M, van der Velde EA, Breimer DD. Relationship between the metabolism of antipyrine, hexobarbitone and theophylline in man as assessed by a 'cocktail' approach. British Journal of Clinical Pharmacology. 26: 373-84. PMID 3190987 DOI: 10.1111/j.1365-2125.1988.tb03394.x  1
1988 Burm AG, Van Kleef JW, Vermeulen NP, Olthof G, Breimer DD, Spierdijk J. Pharmacokinetics of lidocaine and bupivacaine following subarachnoid administration in surgical patients: simultaneous investigation of absorption and disposition kinetics using stable isotopes. Anesthesiology. 69: 584-92. PMID 3177919  1
1988 van der Graaff M, Vermeulen NP, Breimer DD. Disposition of hexobarbital: 15 years of an intriguing model substrate. Drug Metabolism Reviews. 19: 109-64. PMID 3069420 DOI: 10.3109/03602538809049621  1
1987 Cohen AF, Land GS, Breimer DD, Yuen WC, Winton C, Peck AW. Lamotrigine, a new anticonvulsant: pharmacokinetics in normal humans. Clinical Pharmacology and Therapeutics. 42: 535-41. PMID 3677542 DOI: 10.1038/clpt.1987.193  1
1987 Burm AG, Vermeulen NP, van Kleef JW, de Boer AG, Spierdijk J, Breimer DD. Pharmacokinetics of lignocaine and bupivacaine in surgical patients following epidural administration. Simultaneous investigation of absorption and disposition kinetics using stable isotopes. Clinical Pharmacokinetics. 13: 191-203. PMID 3665324 DOI: 10.2165/00003088-198713030-00004  1
1987 van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. Correlation of apparent intrinsic clearances of simultaneously administered S (+) and d3R (-) hexobarbital in the rat. Biochemical Pharmacology. 36: 1321-3. PMID 3593417  1
1987 Zoetemelk CE, Mohn GR, van der Gen A, Breimer DD. 1,2-Dibromo compounds. Their mutagenicity in Salmonella strains differing in glutathione content and their alkylating potential. Biochemical Pharmacology. 36: 1829-35. PMID 3555505 DOI: 10.1016/0006-2952(87)90246-2  1
1987 Schellens JH, Breimer DD. Variability in drug metabolism: importance of genetic constitution. Pharmaceutisch Weekblad. Scientific Edition. 9: 85-90. PMID 3295765  1
1986 van der Graaff M, Vermeulen NP, Heij P, de Bree H, Breimer DD. Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 16: 1091-6. PMID 3798956 DOI: 10.3109/00498258609038986  1
1986 Van der Graaff M, Vermeulen NP, Vinks MH, Breimer DD. Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat. European Journal of Drug Metabolism and Pharmacokinetics. 11: 107-11. PMID 3770011  1
1986 Van der Graaff M, Vermeulen NP, Koperdraat MC, Breimer DD. Non-linear pharmacokinetics of sparteine in the rat. Archives Internationales De Pharmacodynamie Et De ThéRapie. 282: 181-95. PMID 3767526  1
1986 van der Graaff M, Vermeulen NP, Heij P, Boeijinga JK, Breimer DD. Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects. Biopharmaceutics & Drug Disposition. 7: 265-72. PMID 3730526  1
1986 Van der Graaff M, Vermeulen NP, Breimer DD. Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Pharmaceutisch Weekblad. Scientific Edition. 8: 139-44. PMID 3714437  1
1986 Buijs W, van Meeteren-Wälchli B, Breimer DD, van der Gen A. An improved synthesis of 3-hydroxymethylantipyrine using antipyrine as starting material. Arzneimittel-Forschung. 36: 419-21. PMID 3707658  1
1986 van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. Stereospecific analysis of racemic hexobarbital in rat blood by enantioselective capillary gas chromatography. Journal of Chromatography. 375: 411-5. PMID 3700566  1
1986 van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. The influence of pretreatment on the urinary metabolite profile of pseudoracemic hexobarbital. Biochemical Pharmacology. 35: 3166-9. PMID 3092834  1
1986 Van der Graaff M, Vermeulen NP, Crul IE, Breimer DD. Dose-dependent pharmacokinetics of zoxazolamine in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 14: 331-5. PMID 2872034  1
1985 Teunissen MW, Kampf D, Roots I, Vermeulen NP, Breimer DD. Antipyrine metabolite formation and excretion in patients with chronic renal failure. European Journal of Clinical Pharmacology. 28: 589-95. PMID 4043202  1
1985 van der Graaff M, Hofman PH, Breimer DD, Vermeulen NP, Knabe J, Schamber L. Selected ion monitoring analysis of pseudoracemic hexobarbital and its major metabolites in blood and urine of rats. Biomedical Mass Spectrometry. 12: 464-9. PMID 2932174  1
1985 Van der Graaff M, Vermeulen NP, Breimer DD. Route- and dose-dependent pharmacokinetics of hexobarbitone in the rat: a re-evaluation of the use of sleeping times in metabolic studies. The Journal of Pharmacy and Pharmacology. 37: 550-4. PMID 2864415  1
1984 Kleinbloesem CH, van Brummelen P, Faber H, Danhof M, Vermeulen NP, Breimer DD. Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man. Biochemical Pharmacology. 33: 3721-4. PMID 6508829  1
1984 van der Graaff M, Vermeulen NP, Joeres RP, Breimer DD. Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt. Pharmacology. 29: 99-109. PMID 6473507  1
1984 Buijs W, van der Gen A, Mohn GR, Breimer DD. The direct mutagenic activity of alpha, omega-dihalogenoalkanes in Salmonella typhimurium. Strong correlation between chemical properties and mutagenic activity. Mutation Research. 141: 11-4. PMID 6384769 DOI: 10.1016/0165-7992(84)90029-0  1
1983 de Wolff FA, Vermeij P, Ferrari MD, Buruma OJS, Breimer DD. Impairment of phenytoin parahydroxylation as a cause of severe intoxication Therapeutic Drug Monitoring. 5: 213-215. PMID 6879646 DOI: 10.1097/00007691-198306000-00011  1
1983 Vermeulen NP, Danhof M, Setiawan I, Breimer DD. Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 226: 201-5. PMID 6864540  1
1983 Vermeulen NP, Rietveld CT, Breimer DD. Disposition of hexobarbitone in healthy man: kinetics of parent drug and metabolites following oral administration. British Journal of Clinical Pharmacology. 15: 459-64. PMID 6849782  1
1983 Teunissen MW, Meerburg-van der Torren JE, Vermeulen NP, Breimer DD. Automated high-performance liquid chromatographic determination of antipyrine and its main metabolites in plasma, saliva and urine, including 4,4'-dihydroxyantipyrine. Journal of Chromatography. 278: 367-78. PMID 6668316  1
1983 Teunissen MW, Van Graft M, Vermeulen NP, Breimer DD. Influence of allylisopropylacetamide and phenobarbital treatment on in vivo antipyrine metabolite formation in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 13: 497-502. PMID 6649682 DOI: 10.3109/00498258309052289  1
1983 van der Graaff M, Vermeulen NP, Joeres RP, Vlietstra T, Breimer DD. Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats. The Journal of Pharmacology and Experimental Therapeutics. 227: 459-65. PMID 6631725  1
1983 Teunissen MW, Joeres RP, Vermeulen NP, Breimer DD. Influence of 9-hydroxyellipticine and 3-methylcholanthrene treatment on antipyrine metabolite formation in rats in vivo. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 13: 223-31. PMID 6624137  1
1983 van der Graaff M, Vermeulen NP, Joeres RP, Breimer DD. Disposition of hexobarbital enantiomers in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 11: 489-93. PMID 6138236  1
1983 van der Graaff M, Vermeulen NP, Langendijk PN, Breimer DD. Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies. The Journal of Pharmacology and Experimental Therapeutics. 225: 747-51. PMID 6134816  1
1981 van Bladeren PJ, Breimer DD, van Huijgevoort JA, Vermeulen NP, van der Gen A. The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo. Biochemical Pharmacology. 30: 2499-502. PMID 21043256  1
1981 Heusler H, Epping J, Heusler S, Richter E, Vermeulen NP, Breimer DD. Simultaneous determination of blood concentrations of methohexital and its hydroxy metabolite by gas chromatography and identification of 4'-hydroxymethohexital by combined gas--liquid chromatography--mass spectrometry. Journal of Chromatography. 226: 403-12. PMID 7320169  1
1981 van Bladeren PJ, Breimer DD, Rotteveel-Smijs GM, de Knijff P, Mohn GR, van Meeteren-Wälchli B, Buijs W, van der Gen A. The relation between the structure of vicinal dihalogen compounds and their mutagenic activation via conjugation to glutathione. Carcinogenesis. 2: 499-505. PMID 7273330  1
1981 van Bladeren PJ, Breimer DD, Rotteveel-Smijs GM, Hoogeterp JJ, Mohn GR, de Groot A, van Zeeland AA, van der Gen A. The activating role of glutathione in the mutagenicity of 1,2-dibromoethane. Advances in Experimental Medicine and Biology. 136: 809-20. PMID 7046382  1
1981 van Bladeren PJ, Hoogeterp JJ, Breimer DD, van der Gen A. The influence of disulfiram and other inhibitors of oxidative metabolism on the formation of 2-hydroxyethyl-mercapturic acid from 1,2-dibromoethane by the rat. Biochemical Pharmacology. 30: 2983-7. PMID 7032529 DOI: 10.1016/0006-2952(81)90263-X  1
1981 Vermeulen NP, Breimer DD, Holthuis J, Mol C, Bakker BH, van der Gen A. The metabolic fate of 1',2'-epoxyhexobarbital in the rat. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 11: 547-57. PMID 7029928 DOI: 10.3109/00498258109045866  1
1981 Vermeulen NP, Bakker BH, Eylers D, Breimer DD. The epoxide-diol pathway in the metabolism of vinylbital in rat and man. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 10: 159-68. PMID 6110286 DOI: 10.3109/00498258009033742  0.36
1981 Tukker JJ, Crombeen JP, Breimer DD, De Blaey CJ. The bioavailability of seven commercially available rectal aminophylline suppositories Pharmaceutisch Weekblad Scientific Edition. 3: 1325-1335. DOI: 10.1007/BF02193383  1
1980 van Bladeren PJ, Breimer DD, Rotteveel-Smijs GM, Mohn GR. Mutagenic activation of dibromomethane and diiodomethane by mammalian microsomes and glutathione S-transferases. Mutation Research. 74: 341-6. PMID 7010125 DOI: 10.1016/0165-1161(80)90192-2  1
1980 van Bladeren PJ, Breimer DD, Rotteveel-Smijs GM, de Jong RA, Buijs W, van der Gen A, Mohn GR. The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane. Biochemical Pharmacology. 29: 2975-82. PMID 7006609 DOI: 10.1016/0006-2952(80)90047-7  1
1980 Baars AJ, Blijleven WG, Mohn GR, Natarajan AT, Breimer DD. Preliminary studies on the ability of Drosophila microsomal preparations to activate mutagens and carcinogens. Mutation Research. 72: 257-64. PMID 6777691 DOI: 10.1016/0027-5107(80)90040-8  1
1980 Lagas M, Lerk CF, Breimer DD. Increased gastro-intestinal absorption of hexobarbital by hydrophilization Pharmaceutisch Weekblad Scientific Edition. 2: 541-547. DOI: 10.1007/BF02273084  1
1979 Vermeulen NP, Bakker BH, Schultink J, van der Gen A, Breimer DD. The epoxide-diol pathway in the metabolism of hexobarbital in rat and man. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 9: 289-99. PMID 494660 DOI: 10.3109/00498257909038732  1
1979 van Bladeren PJ, van der Gen A, Breimer DD, Mohn GR. Stereoselective activation of vicinal dihalogen compounds to mutagens by glutathione conjugation. Biochemical Pharmacology. 28: 2521-4. PMID 389247 DOI: 10.1016/0006-2952(79)90019-4  1
1978 Vermeulen NP, Teunissen MW, Breimer DD. Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection. Journal of Chromatography. 157: 133-40. PMID 701438 DOI: 10.1016/S0021-9673(00)92329-X  0.4
1978 Vermeulen NP, van Bladeren PJ, Breimer DD, van der Gen A. Hexobarbital-1',2'-epoxide: a possible intermediate in the metabolism of hexobarbital. Biochemical Pharmacology. 27: 135-8. PMID 619900 DOI: 10.1016/0006-2952(78)90274-5  1
1977 Vermeulen NP, de Roode D, Breimer DD. Gas chromatographic determination of pemoline as 5-phenyl-2,4-oxazolidinedione in human urine. Journal of Chromatography. 137: 333-42. PMID 881457 DOI: 10.1016/S0021-9673(00)81356-4  0.48
1975 Breimer DD, Honhoff C, Zilly W, Richter E, van Rossum JM. Pharmocokinetics of hexobarbital in man after intravenous infusion. Journal of Pharmacokinetics and Biopharmaceutics. 3: 1-11. PMID 1127574 DOI: 10.1007/BF01066591  1
1974 Breimer DD, van Rossum JM. Pharmacokinetics of the enantiomers of hexobarbital studied in the same intact rat and in the same isolated perfused rat liver. European Journal of Pharmacology. 26: 321-30. PMID 4853606 DOI: 10.1016/0014-2999(74)90243-X  1
1974 Breimer DD, Van Rossum JM. Rapid and sensitive gas chromatographic determination of hexobarbital in plasma of man using a nitrogen detector. Journal of Chromatography. 88: 235-43. PMID 4814347 DOI: 10.1016/S0021-9673(00)83147-7  1
1974 Breimer DD, Ketelaars HCJ, Van Rossum JM. Gas chromatographic determination of chloral hydrate, trichloroethanol and trichloroacetic acid in blood and in urine employing head-space analysis Journal of Chromatography A. 88: 55-63. DOI: 10.1016/S0021-9673(01)91772-8  1
1973 Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Gas chromatography of cannabinoids. Gas chromatographic behaviour of cis- and trans- tetrahydrocannabinol and isotetrahydrocannabinol. Journal of Chromatography. 79: 81-90. PMID 4708862 DOI: 10.1016/S0021-9673(01)85276-6  1
1973 Breimer DD, van Rossum JM. Letter: Pharmacokinetics of (+)-, (-)- and (plus or minus)-hexobarbitone in man after oral administration. The Journal of Pharmacy and Pharmacology. 25: 762-4. PMID 4148519 DOI: 10.1111/j.2042-7158.1973.tb10066.x  1
1972 de Zeeuw RA, Wijsbeek J, Breimer DD, Vree TB, van Ginneken CA, van Rossum JM. Cannabinoids with a propyl side chain in cannabis: occurrence and chromatographic behavior. Science (New York, N.Y.). 175: 778-9. PMID 5057817  1
1972 Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Gas chromatography of cannabis constituents and their synthetic derivatives. Journal of Chromatography. 74: 209-24. PMID 4645669  1
1972 Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Identification of cannabicyclol with a pentyl or propyl side-chain by means of combined gas chromatography-mass spectrometry. Journal of Chromatography. 74: 124-7. PMID 4635939  1
1972 Vree TB, Breimer DD, van Ginneken CA, van Rossum JM. Identification in hashish of tetrahydrocannabinol, cannabidiol and cannabinol analogues with a methyl side-chain. The Journal of Pharmacy and Pharmacology. 24: 7-12. PMID 4401327  1
1971 Vree TB, Breimer DD, van Ginneken CA, van Rossum JM, de Zeeuw RA, Witte AH. Identification of cannabivarins in hashish by a new method of combined gas chromatography-mass-spectrometry. Clinica Chimica Acta; International Journal of Clinical Chemistry. 34: 365-72. PMID 5113572  1
1971 Vree TB, van Rossum JM, Breimer DD, van Ginneken GA, van Kordelaar JM. Gas-liquid chromatography in pharmacology and toxicology. Pharmacokinetic analysis limited by the sensitivity of the analytical technique. Clinica Chimica Acta; International Journal of Clinical Chemistry. 34: 311-9. PMID 5113568  1
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