| Year |
Citation |
Score |
| 2017 |
den Braver MW, Vermeulen NP, Commandeur JN. Generic method for the absolute quantification of glutathione S-conjugates: Application to the conjugates of acetaminophen, clozapine and diclofenac. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1046: 185-194. PMID 28189104 DOI: 10.1016/J.Jchromb.2017.02.004 |
0.339 |
|
| 2016 |
Dekker SJ, Zhang Y, Vos JC, Vermeulen NP, Commandeur JN. Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation. Chemical Research in Toxicology. 29: 2136-2144. PMID 27989146 DOI: 10.1021/Acs.Chemrestox.6B00250 |
0.409 |
|
| 2016 |
Zhang Y, Vermeulen NP, Commandeur JN. Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N-desethylamodiaquine. British Journal of Clinical Pharmacology. PMID 27718269 DOI: 10.1111/Bcp.13148 |
0.397 |
|
| 2016 |
den Braver MW, Zhang Y, Venkataraman H, Vermeulen NP, Commandeur JN. Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicology Letters. PMID 27183920 DOI: 10.1016/J.Toxlet.2016.05.015 |
0.381 |
|
| 2016 |
den Braver MW, den Braver-Sewradj SP, Vermeulen NP, Commandeur JN. Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines. Toxicology Letters. 253: 46-54. PMID 27130197 DOI: 10.1016/J.Toxlet.2016.04.022 |
0.403 |
|
| 2016 |
den Braver-Sewradj SP, den Braver MW, Vermeulen NP, Commandeur JN, Richert L, Vos JC. Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer. Toxicology in Vitro : An International Journal Published in Association With Bibra. PMID 26921663 DOI: 10.1016/J.Tiv.2016.02.013 |
0.323 |
|
| 2016 |
Capoferri L, Leth R, Ter Haar E, Mohanty AK, Grootenhuis PD, Vottero E, Commandeur JN, Vermeulen NP, Jørgensen FS, Olsen L, Geerke DP. Insights into regioselective metabolism of mefenamic acid by Cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations. Proteins. PMID 26757175 DOI: 10.1002/Prot.24985 |
0.364 |
|
| 2016 |
Reinen J, Postma G, Tump C, Bloemberg T, Engel J, Vermeulen NP, Commandeur JN, Honing M. Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity. Analytical and Bioanalytical Chemistry. PMID 26753974 DOI: 10.1007/S00216-015-9241-X |
0.34 |
|
| 2015 |
Capoferri L, Verkade-Vreeker MC, Buitenhuis D, Commandeur JN, Pastor M, Vermeulen NP, Geerke DP. Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation. Plos One. 10: e0142232. PMID 26551865 DOI: 10.1371/Journal.Pone.0142232 |
0.315 |
|
| 2015 |
Reinen J, Nematollahi L, Fidder A, Vermeulen NP, Noort D, Commandeur JN. Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP). Chemical Research in Toxicology. 28: 711-21. PMID 25706813 DOI: 10.1021/Tx500490V |
0.331 |
|
| 2015 |
Venkataraman H, Te Poele EM, Rosłoniec KZ, Vermeulen N, Commandeur JN, van der Geize R, Dijkhuizen L. Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme. Applied Microbiology and Biotechnology. 99: 4713-21. PMID 25511824 DOI: 10.1007/S00253-014-6281-7 |
0.336 |
|
| 2015 |
Reinen J, Vermeulen NP. Biotransformation of endocrine disrupting compounds by selected phase I and phase II enzymes--formation of estrogenic and chemically reactive metabolites by cytochromes P450 and sulfotransferases. Current Medicinal Chemistry. 22: 500-27. PMID 25245506 DOI: 10.2174/0929867321666140916123022 |
0.353 |
|
| 2015 |
De Zwart LL, Hermanns RC, Meerman JH, Commandeur JN, Salem Ink PJ, Vermeulen NP. Excretion of multiple urinary biomarkers for radical induced damage in rats treated with three different nephrotoxic compounds. Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals. 3: 347-65. PMID 23899362 DOI: 10.1080/135475098231156 |
0.332 |
|
| 2014 |
Boerma JS, Elias NS, Vermeulen NP, Commandeur JN. Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites. Journal of Pharmaceutical and Biomedical Analysis. 103: 17-25. PMID 25462116 DOI: 10.1016/J.Jpba.2014.10.025 |
0.373 |
|
| 2014 |
Vredenburg G, den Braver-Sewradj S, van Vugt-Lussenburg BM, Vermeulen NP, Commandeur JN, Vos JC. Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants. Toxicology Letters. 232: 182-192. PMID 25448283 DOI: 10.1016/J.Toxlet.2014.11.005 |
0.405 |
|
| 2014 |
Venkataraman H, den Braver MW, Vermeulen NP, Commandeur JN. Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases. Chemical Research in Toxicology. 27: 2071-81. PMID 25372302 DOI: 10.1021/Tx500288B |
0.419 |
|
| 2014 |
Venkataraman H, Verkade-Vreeker MC, Capoferri L, Geerke DP, Vermeulen NP, Commandeur JN. Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs. Bioorganic & Medicinal Chemistry. 22: 5613-20. PMID 24999003 DOI: 10.1016/J.Bmc.2014.06.022 |
0.375 |
|
| 2014 |
Vredenburg G, Elias NS, Venkataraman H, Hendriks DF, Vermeulen NP, Commandeur JN, Vos JC. Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid. Chemical Research in Toxicology. 27: 576-86. PMID 24552538 DOI: 10.1021/Tx400431K |
0.435 |
|
| 2014 |
Boerma JS, Vermeulen NP, Commandeur JN. One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac. Chemico-Biological Interactions. 207: 32-40. PMID 24246759 DOI: 10.1016/J.Cbi.2013.11.001 |
0.375 |
|
| 2014 |
Dragovic S, Venkataraman H, Begheijn S, Vermeulen NP, Commandeur JN. Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen. Toxicology Letters. 224: 272-81. PMID 24185126 DOI: 10.1016/J.Toxlet.2013.10.023 |
0.369 |
|
| 2013 |
Dragovic S, Boerma JS, Vermeulen NP, Commandeur JN. Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac. Chemical Research in Toxicology. 26: 1632-41. PMID 24083800 DOI: 10.1021/Tx400204D |
0.417 |
|
| 2013 |
Vredenburg G, Vassell KP, Commandeur JN, Vermeulen NP, Vos JC. Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast. Toxicology Letters. 222: 247-56. PMID 23916688 DOI: 10.1016/J.Toxlet.2013.07.023 |
0.396 |
|
| 2013 |
Dragovic S, Gunness P, Ingelman-Sundberg M, Vermeulen NP, Commandeur JN. Characterization of human cytochrome P450s involved in the bioactivation of clozapine. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 651-8. PMID 23297297 DOI: 10.1124/Dmd.112.050484 |
0.401 |
|
| 2012 |
Boerma JS, Dragovic S, Vermeulen NP, Commandeur JN. Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1. Chemical Research in Toxicology. 25: 2532-41. PMID 22998212 DOI: 10.1021/Tx300334W |
0.335 |
|
| 2012 |
van Leeuwen JS, Vermeulen NP, Chris Vos J. Yeast as a humanized model organism for biotransformation-related toxicity. Current Drug Metabolism. 13: 1464-75. PMID 22935071 DOI: 10.2174/138920012803762783 |
0.38 |
|
| 2012 |
Rea V, Kolkman AJ, Vottero E, Stronks EJ, Ampt KA, Honing M, Vermeulen NP, Wijmenga SS, Commandeur JN. Active site substitution A82W improves the regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalized by spin relaxation nuclear magnetic resonance studies. Biochemistry. 51: 750-60. PMID 22208729 DOI: 10.1021/Bi201433H |
0.315 |
|
| 2012 |
Oostenbrink C, de Ruiter A, Hritz J, Vermeulen N. Malleability and versatility of cytochrome P450 active sites studied by molecular simulations. Current Drug Metabolism. 13: 190-6. PMID 22208533 DOI: 10.2174/138920012798918453 |
0.333 |
|
| 2012 |
de Beer SB, van Bergen LA, Keijzer K, Rea V, Venkataraman H, Guerra CF, Bickelhaupt FM, Vermeulen NP, Commandeur JN, Geerke DP. The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by cytochrome P450 BM3 mutants. Current Drug Metabolism. 13: 155-66. PMID 22208530 DOI: 10.2174/138920012798918471 |
0.336 |
|
| 2012 |
van Leeuwen JS, Unlü B, Vermeulen NP, Vos JC. Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs. Toxicology in Vitro : An International Journal Published in Association With Bibra. 26: 197-205. PMID 22138569 DOI: 10.1016/J.Tiv.2011.11.013 |
0.336 |
|
| 2012 |
Hissink EM, Bogaards JJ, Freidig AP, Commandeur JN, Vermeulen NP, van Bladeren PJ. The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene. Environmental Toxicology and Pharmacology. 11: 259-71. PMID 21782610 DOI: 10.1016/S1382-6689(02)00019-4 |
0.397 |
|
| 2012 |
Alexidis AN, Commandeur JN, Rekka EA, Groot E, Kourounakis PN, Vermeulen NP. Novel piperidine derivatives: inhibitory properties towards cytochrome P450 isoforms, and cytoprotective and cytotoxic characteristics. Environmental Toxicology and Pharmacology. 1: 81-8. PMID 21781666 DOI: 10.1016/1382-6689(95)00012-7 |
0.37 |
|
| 2012 |
Bessems JG, Van Stee LL, Commandeur JN, Groot EJ, Vermeulen NP. Cytotoxicity of paracetamol and 3,5-dihalogenated analogues: Role of cytochrome P-450 and formation of GSH conjugates and protein adducts. Toxicology in Vitro : An International Journal Published in Association With Bibra. 11: 9-19. PMID 20654292 DOI: 10.1016/S0887-2333(96)00066-5 |
0.41 |
|
| 2011 |
Rea V, Dragovic S, Boerma JS, de Kanter FJ, Vermeulen NP, Commandeur JN. Role of residue 87 in the activity and regioselectivity of clozapine metabolism by drug-metabolizing CYP102A1 M11H: application for structural characterization of clozapine GSH conjugates. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 2411-20. PMID 21890734 DOI: 10.1124/Dmd.111.041046 |
0.408 |
|
| 2011 |
Reinen J, van Leeuwen JS, Li Y, Sun L, Grootenhuis PD, Decker CJ, Saunders J, Vermeulen NP, Commandeur JN. Efficient screening of cytochrome P450 BM3 mutants for their metabolic activity and diversity toward a wide set of drug-like molecules in chemical space. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1568-76. PMID 21673132 DOI: 10.1124/Dmd.111.039461 |
0.368 |
|
| 2011 |
Boerma JS, Vermeulen NP, Commandeur JN. Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites. Chemical Research in Toxicology. 24: 1263-74. PMID 21639118 DOI: 10.1021/Tx2001515 |
0.338 |
|
| 2011 |
Vottero E, Rea V, Lastdrager J, Honing M, Vermeulen NP, Commandeur JN. Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 16: 899-912. PMID 21567268 DOI: 10.1007/S00775-011-0789-4 |
0.387 |
|
| 2011 |
Park BK, Boobis A, Clarke S, Goldring CE, Jones D, Kenna JG, Lambert C, Laverty HG, Naisbitt DJ, Nelson S, Nicoll-Griffith DA, Obach RS, Routledge P, Smith DA, Tweedie DJ, ... Vermeulen N, et al. Managing the challenge of chemically reactive metabolites in drug development. Nature Reviews. Drug Discovery. 10: 292-306. PMID 21455238 DOI: 10.1038/Nrd3408 |
0.321 |
|
| 2011 |
Orhan H, Vermeulen NP. Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates. Current Drug Metabolism. 12: 383-94. PMID 21395525 DOI: 10.2174/138920011795202974 |
0.358 |
|
| 2011 |
Reinen J, Ferman S, Vottero E, Vermeulen NP, Commandeur JN. Application of a fluorescence-based continuous-flow bioassay to screen for diversity of cytochrome P450 BM3 mutant libraries. Journal of Biomolecular Screening. 16: 239-50. PMID 21297109 DOI: 10.1177/1087057110394180 |
0.316 |
|
| 2011 |
van Leeuwen JS, Vredenburg G, Dragovic S, Tjong TF, Vos JC, Vermeulen NP. Metabolism related toxicity of diclofenac in yeast as model system. Toxicology Letters. 200: 162-8. PMID 21111035 DOI: 10.1016/J.Toxlet.2010.11.010 |
0.366 |
|
| 2011 |
Reinen J, Kalma LL, Begheijn S, Heus F, Commandeur JN, Vermeulen NP. Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 41: 59-70. PMID 21087115 DOI: 10.3109/00498254.2010.525762 |
0.395 |
|
| 2010 |
Dragovic S, Boerma JS, van Bergen L, Vermeulen NP, Commandeur JN. Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine. Chemical Research in Toxicology. 23: 1467-76. PMID 20849150 DOI: 10.1021/Tx100131F |
0.402 |
|
| 2010 |
Vasanthanathan P, Olsen L, Jørgensen FS, Vermeulen NP, Oostenbrink C. Computational prediction of binding affinity for CYP1A2-ligand complexes using empirical free energy calculations. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 38: 1347-54. PMID 20413725 DOI: 10.1124/Dmd.110.032946 |
0.308 |
|
| 2010 |
de Vlieger JS, Kolkman AJ, Ampt KA, Commandeur JN, Vermeulen NP, Kool J, Wijmenga SS, Niessen WM, Irth H, Honing M. Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 878: 667-74. PMID 20149764 DOI: 10.1016/J.Jchromb.2010.01.035 |
0.319 |
|
| 2010 |
Palma BB, Silva E Sousa M, Vosmeer CR, Lastdrager J, Rueff J, Vermeulen NP, Kranendonk M. Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression. The Pharmacogenomics Journal. 10: 478-88. PMID 20125119 DOI: 10.1038/Tpj.2010.2 |
0.381 |
|
| 2010 |
Stjernschantz E, Reinen J, Meinl W, George BJ, Glatt H, Vermeulen NP, Oostenbrink C. Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico--implications for differences in activity, subunit dimerization and substrate inhibition. Molecular and Cellular Endocrinology. 317: 127-40. PMID 20025931 DOI: 10.1016/J.Mce.2009.12.001 |
0.318 |
|
| 2009 |
Appiah-Opong R, Commandeur JN, Istyastono E, Bogaards JJ, Vermeulen NP. Inhibition of human glutathione S-transferases by curcumin and analogues. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 39: 302-11. PMID 19350453 DOI: 10.1080/00498250802702316 |
0.325 |
|
| 2009 |
Vasanthanathan P, Hritz J, Taboureau O, Olsen L, Jørgensen FS, Vermeulen NP, Oostenbrink C. Virtual screening and prediction of site of metabolism for cytochrome P450 1A2 ligands. Journal of Chemical Information and Modeling. 49: 43-52. PMID 19099399 DOI: 10.1021/Ci800371F |
0.347 |
|
| 2009 |
Vasanthanathan P, Taboureau O, Oostenbrink C, Vermeulen NP, Olsen L, Jørgensen FS. Classification of cytochrome P450 1A2 inhibitors and noninhibitors by machine learning techniques. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 37: 658-64. PMID 19056915 DOI: 10.1124/Dmd.108.023507 |
0.315 |
|
| 2008 |
Appiah-Opong R, Commandeur JN, Axson C, Vermeulen NP. Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 46: 3598-603. PMID 18822337 DOI: 10.1016/J.Fct.2008.09.002 |
0.328 |
|
| 2008 |
Damsten MC, de Vlieger JS, Niessen WM, Irth H, Vermeulen NP, Commandeur JN. Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s. Chemical Research in Toxicology. 21: 2181-7. PMID 18816075 DOI: 10.1021/Tx8002593 |
0.398 |
|
| 2008 |
Stjernschantz E, Vermeulen NP, Oostenbrink C. Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450. Expert Opinion On Drug Metabolism & Toxicology. 4: 513-27. PMID 18484912 DOI: 10.1517/17425255.4.5.513 |
0.336 |
|
| 2008 |
Appiah-Opong R, de Esch I, Commandeur JN, Andarini M, Vermeulen NP. Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues. European Journal of Medicinal Chemistry. 43: 1621-31. PMID 18249473 DOI: 10.1016/J.Ejmech.2007.10.034 |
0.368 |
|
| 2008 |
Jenkins RE, Kitteringham NR, Goldring CE, Dowdall SM, Hamlett J, Lane CS, Boerma JS, Vermeulen NP, Park BK. Glutathione-S-transferase pi as a model protein for the characterisation of chemically reactive metabolites. Proteomics. 8: 301-15. PMID 18203258 DOI: 10.1002/Pmic.200700843 |
0.368 |
|
| 2008 |
Damsten MC, van Vugt-Lussenburg BM, Zeldenthuis T, de Vlieger JS, Commandeur JN, Vermeulen NP. Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites. Chemico-Biological Interactions. 171: 96-107. PMID 17996858 DOI: 10.1016/J.Cbi.2007.09.007 |
0.388 |
|
| 2008 |
Stjernschantz E, van Vugt-Lussenburg BM, Bonifacio A, de Beer SB, van der Zwan G, Gooijer C, Commandeur JN, Vermeulen NP, Oostenbrink C. Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3. Proteins. 71: 336-52. PMID 17957765 DOI: 10.1002/Prot.21697 |
0.383 |
|
| 2008 |
Bonifacio A, Millo D, Keizers PH, Boegschoten R, Commandeur JN, Vermeulen NP, Gooijer C, van der Zwan G. Active-site structure, binding and redox activity of the heme-thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 13: 85-96. PMID 17899220 DOI: 10.1007/S00775-007-0303-1 |
0.3 |
|
| 2008 |
Leeuwen Jv, Vos C, Vermeulen N. Drug metabolites induce toxicity in bioactivation competent yeast Toxicology Letters. 180. DOI: 10.1016/J.Toxlet.2008.06.470 |
0.318 |
|
| 2007 |
Kool J, van Liempd SM, Harmsen S, Beckman J, van Elswijk D, Commandeur JN, Irth H, Vermeulen NP. Cytochrome P450 bio-affinity detection coupled to gradient HPLC: on-line screening of affinities to cytochrome P4501A2 and 2D6. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 858: 49-58. PMID 17826363 DOI: 10.1016/J.Jchromb.2007.08.005 |
0.338 |
|
| 2007 |
Martínez-Cabot A, Morató A, Commandeur JN, Vermeulen NP, Messeguer A. In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome. Chemical Research in Toxicology. 20: 1218-24. PMID 17672514 DOI: 10.1021/Tx700209P |
0.378 |
|
| 2007 |
Damsten MC, Commandeur JN, Fidder A, Hulst AG, Touw D, Noort D, Vermeulen NP. Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1408-17. PMID 17510247 DOI: 10.1124/Dmd.106.014233 |
0.348 |
|
| 2007 |
Kool J, Van Liempd SM, Harmsen S, Schenk T, Irth H, Commandeur JN, Vermeulen NP. An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures. Analytical and Bioanalytical Chemistry. 388: 871-9. PMID 17468853 DOI: 10.1007/S00216-007-1296-X |
0.311 |
|
| 2007 |
Appiah-Opong R, Commandeur JN, van Vugt-Lussenburg B, Vermeulen NP. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. Toxicology. 235: 83-91. PMID 17433521 DOI: 10.1016/J.Tox.2007.03.007 |
0.349 |
|
| 2007 |
Kool J, Eggink M, van Rossum H, van Liempd SM, van Elswijk DA, Irth H, Commandeur JN, Meerman JH, Vermeulen NP. Online biochemical detection of glutathione-S-transferase P1-specific inhibitors in complex mixtures. Journal of Biomolecular Screening. 12: 396-405. PMID 17379858 DOI: 10.1177/1087057107299527 |
0.331 |
|
| 2007 |
Feenstra KA, Starikov EB, Urlacher VB, Commandeur JN, Vermeulen NP. Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants. Protein Science : a Publication of the Protein Society. 16: 420-31. PMID 17322527 DOI: 10.1110/Ps.062224407 |
0.313 |
|
| 2007 |
Bonifacio A, Groenhof AR, Keizers PH, de Graaf C, Commandeur JN, Vermeulen NP, Ehlers AW, Lammertsma K, Gooijer C, van der Zwan G. Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 12: 645-54. PMID 17318599 DOI: 10.1007/S00775-007-0210-5 |
0.309 |
|
| 2007 |
de Graaf C, Oostenbrink C, Keizers PH, van Vugt-Lussenburg BM, van Waterschoot RA, Tschirret-Guth RA, Commandeur JN, Vermeulen NP. Molecular modeling-guided site-directed mutagenesis of cytochrome P450 2D6. Current Drug Metabolism. 8: 59-77. PMID 17266524 DOI: 10.2174/138920007779315062 |
0.352 |
|
| 2007 |
van Vugt-Lussenburg BM, Stjernschantz E, Lastdrager J, Oostenbrink C, Vermeulen NP, Commandeur JN. Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis. Journal of Medicinal Chemistry. 50: 455-61. PMID 17266197 DOI: 10.1021/Jm0609061 |
0.359 |
|
| 2007 |
Kool J, van Liempd SM, van Rossum H, van Elswijk DA, Irth H, Commandeur JN, Vermeulen NP. Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 640-8. PMID 17251308 DOI: 10.1124/Dmd.106.012245 |
0.367 |
|
| 2006 |
Keizers PH, Van Dijk BR, De Graaf C, Van Vugt-Lussenburg BM, Vermeulen NP, Commandeur JN. Metabolism of N-substituted 7-methoxy-4-(aminomethyl) -coumarins by cytochrome P450 2D6 mutants and the indication of additional substrate interaction points. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 36: 763-71. PMID 16971342 DOI: 10.1080/00498250600765325 |
0.373 |
|
| 2006 |
Reinen J, Vriese E, Glatt H, Vermeulen NP. Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Analytical Biochemistry. 357: 85-92. PMID 16914110 DOI: 10.1016/J.Ab.2006.07.015 |
0.336 |
|
| 2006 |
Onderwater RC, Rettie AE, Commandeur JN, Vermeulen NP. Bioactivation of N-substituted N'-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 36: 645-57. PMID 16864509 DOI: 10.1080/00498250500354329 |
0.349 |
|
| 2006 |
van Liempd SM, Kool J, Niessen WM, van Elswijk DE, Irth H, Vermeulen NP. On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1640-9. PMID 16790557 DOI: 10.1124/Dmd.106.010355 |
0.374 |
|
| 2006 |
van Vugt-Lussenburg BM, Damsten MC, Maasdijk DM, Vermeulen NP, Commandeur JN. Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3. Biochemical and Biophysical Research Communications. 346: 810-8. PMID 16777067 DOI: 10.1016/J.Bbrc.2006.05.179 |
0.382 |
|
| 2006 |
Kool J, Ramautar R, van Liempd SM, Beckman J, de Kanter FJ, Meerman JH, Schenk T, Irth H, Commandeur JN, Vermeulen NP. Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen. Journal of Medicinal Chemistry. 49: 3287-92. PMID 16722647 DOI: 10.1021/Jm0507936 |
0.331 |
|
| 2006 |
Bonifacio A, Keizers PH, Commandeur JN, Vermeulen NP, Robert B, Gooijer C, van der Zwan G. Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy. Biochemical and Biophysical Research Communications. 343: 772-9. PMID 16563352 DOI: 10.1016/J.Bbrc.2006.03.027 |
0.353 |
|
| 2006 |
Orhan H, Gurer-Orhan H, Vriese E, Vermeulen NP, Meerman JH. Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes. Toxicology in Vitro : An International Journal Published in Association With Bibra. 20: 1005-13. PMID 16488111 DOI: 10.1016/J.Tiv.2005.12.012 |
0.303 |
|
| 2006 |
van Waterschoot RA, Keizers PH, de Graaf C, Vermeulen NP, Tschirret-Guth RA. Topological role of cytochrome P450 2D6 active site residues. Archives of Biochemistry and Biophysics. 447: 53-8. PMID 16466686 DOI: 10.1016/J.Abb.2006.01.002 |
0.327 |
|
| 2006 |
Stortelder A, Keizers PH, Oostenbrink C, De Graaf C, De Kruijf P, Vermeulen NP, Gooijer C, Commandeur JN, Van der Zwan G. Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy. The Biochemical Journal. 393: 635-43. PMID 16190863 DOI: 10.1042/Bj20051169 |
0.31 |
|
| 2005 |
van Lipzig MM, Vermeulen NP, Gusinu R, Legler J, Frank H, Seidel A, Meerman JH. Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Environmental Toxicology and Pharmacology. 19: 41-55. PMID 21783461 DOI: 10.1016/J.Etap.2004.03.010 |
0.34 |
|
| 2005 |
van Lipzig MM, Commandeur JN, de Kanter FJ, Damsten MC, Vermeulen NP, Maat E, Groot EJ, Brouwer A, Kester MH, Visser TJ, Meerman JH. Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity. Chemical Research in Toxicology. 18: 1691-700. PMID 16300378 DOI: 10.1021/Tx0501233 |
0.366 |
|
| 2005 |
Keizers PH, Schraven LH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, van Dijk BR, Vermeulen NP, Commandeur JN. Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6. Biochemical and Biophysical Research Communications. 338: 1065-74. PMID 16269134 DOI: 10.1016/J.Bbrc.2005.10.066 |
0.317 |
|
| 2005 |
Keizers PH, de Graaf C, de Kanter FJ, Oostenbrink C, Feenstra KA, Commandeur JN, Vermeulen NP. Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation. Journal of Medicinal Chemistry. 48: 6117-27. PMID 16162012 DOI: 10.1021/Jm050338+ |
0.34 |
|
| 2005 |
Lussenburg BM, Keizers PH, de Graaf C, Hidestrand M, Ingelman-Sundberg M, Vermeulen NP, Commandeur JN. The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent. Biochemical Pharmacology. 70: 1253-61. PMID 16135359 DOI: 10.1016/J.Bcp.2005.07.002 |
0.35 |
|
| 2005 |
Kool J, van Liempd SM, Ramautar R, Schenk T, Meerman JH, Irth H, Commandeur JN, Vermeulen NP. Development of a novel cytochrome p450 bioaffinity detection system coupled online to gradient reversed-phase high-performance liquid chromatography. Journal of Biomolecular Screening. 10: 427-36. PMID 16093552 DOI: 10.1177/1087057105274904 |
0.354 |
|
| 2005 |
Onderwater RC, Commandeur JN, Rooseboom M, Vermeulen NP. Uptake-toxicity relationships of a series of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 35: 391-404. PMID 16019959 DOI: 10.1080/00498250500066154 |
0.351 |
|
| 2005 |
van Liempd SM, Kool J, Reinen J, Schenk T, Meerman JH, Irth H, Vermeulen NP. Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography. Journal of Chromatography. A. 1075: 205-12. PMID 15974134 DOI: 10.1016/J.Chroma.2005.03.084 |
0.349 |
|
| 2005 |
Lussenburg BM, Babel LC, Vermeulen NP, Commandeur JN. Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants. Analytical Biochemistry. 341: 148-55. PMID 15866539 DOI: 10.1016/J.Ab.2005.02.025 |
0.34 |
|
| 2004 |
Keizers PH, Lussenburg BM, de Graaf C, Mentink LM, Vermeulen NP, Commandeur JN. Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism. Biochemical Pharmacology. 68: 2263-71. PMID 15498516 DOI: 10.1016/J.Bcp.2004.08.013 |
0.328 |
|
| 2004 |
Yenes S, Commandeur JN, Vermeulen NP, Messeguer A. In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes. Chemical Research in Toxicology. 17: 904-13. PMID 15257615 DOI: 10.1021/Tx030036F |
0.376 |
|
| 2004 |
Onderwater RC, Commandeur JN, Vermeulen NP. Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices. Toxicology. 197: 81-91. PMID 15003319 DOI: 10.1016/J.Tox.2003.11.014 |
0.366 |
|
| 2004 |
Rooseboom M, Commandeur JN, Vermeulen NP. Enzyme-catalyzed activation of anticancer prodrugs. Pharmacological Reviews. 56: 53-102. PMID 15001663 DOI: 10.1124/Pr.56.1.3 |
0.332 |
|
| 2003 |
Vermeulen NP. Prediction of drug metabolism: the case of cytochrome P450 2D6. Current Topics in Medicinal Chemistry. 3: 1227-39. PMID 12769702 DOI: 10.2174/1568026033451998 |
0.37 |
|
| 2003 |
Venhorst J, Rooseboom M, Vermeulen NP, Commandeur JN. Studies on the inhibition of human cytochromes P450 by selenocysteine Se-conjugates. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 33: 57-72. PMID 12519694 DOI: 10.1080/0049825021000022357 |
0.371 |
|
| 2003 |
Venhorst J, ter Laak AM, Commandeur JN, Funae Y, Hiroi T, Vermeulen NP. Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. Journal of Medicinal Chemistry. 46: 74-86. PMID 12502361 DOI: 10.1021/Jm0209578 |
0.362 |
|
| 2003 |
Rooseboom M, Vermeulen NP, Durgut F, Commandeur JN. Comparative study on the bioactivation mechanisms and cytotoxicity of Te-phenyl-L-tellurocysteine, Se-phenyl-L-selenocysteine, and S-phenyl-L-cysteine. Chemical Research in Toxicology. 15: 1610-8. PMID 12482244 DOI: 10.1021/Tx020034F |
0.335 |
|
| 2002 |
't Hoen PA, Rooseboom M, Bijsterbosch MK, van Berkel TJ, Vermeulen NP, Commandeur JN. Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates. Biochemical Pharmacology. 63: 1843-9. PMID 12034368 DOI: 10.1016/S0006-2952(02)00987-5 |
0.347 |
|
| 2002 |
Rooseboom M, Schaaf G, Commandeur JN, Vermeulen NP, Fink-Gremmels J. Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines. The Journal of Pharmacology and Experimental Therapeutics. 301: 884-92. PMID 12023515 DOI: 10.1124/Jpet.301.3.884 |
0.306 |
|
| 2002 |
Rooseboom M, Vermeulen NP, Commandeur JN. Enzymatic pathways of beta elimination of chemopreventive selenocysteine Se conjugates. Methods in Enzymology. 348: 191-200. PMID 11885272 DOI: 10.1016/S0076-6879(02)48638-7 |
0.361 |
|
| 2001 |
Rooseboom M, Vermeulen NP, van Hemert N, Commandeur JN. Bioactivation of chemopreventive selenocysteine Se-conjugates and related amino acids by amino acid oxidases novel route of metabolism of selenoamino acids. Chemical Research in Toxicology. 14: 996-1005. PMID 11511173 DOI: 10.1021/Tx000265R |
0.334 |
|
| 2001 |
Bessems JG, Vermeulen NP. Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches. Critical Reviews in Toxicology. 31: 55-138. PMID 11215692 DOI: 10.1080/20014091111677 |
0.335 |
|
| 2001 |
Rooseboom M, Commandeur JN, Floor GC, Rettie AE, Vermeulen NP. Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates. Chemical Research in Toxicology. 14: 127-34. PMID 11170516 DOI: 10.1021/Tx0001326 |
0.419 |
|
| 2001 |
Venhorst J, Onderwater RC, Meerman JH, Vermeulen NP, Commandeur JN. Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 12: 151-8. PMID 11102743 DOI: 10.1016/S0928-0987(00)00150-0 |
0.316 |
|
| 2000 |
Hoen PA, Commandeur JN, Vermeulen NP, Van Berkel TJ, Bijsterbosch MK. Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign. Biochemical Pharmacology. 60: 1509-18. PMID 11020454 DOI: 10.1016/S0006-2952(00)00454-8 |
0.366 |
|
| 2000 |
Hissink AM, Wormhoudt LW, Sherratt PJ, Hayes JD, Commandeur JN, Vermeulen NP, van Bladeren PJ. A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 38: 707-16. PMID 10908818 DOI: 10.1016/S0278-6915(00)00059-4 |
0.37 |
|
| 1999 |
Onderwater RC, Venhorst J, Commandeur JN, Vermeulen NP. Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening. Chemical Research in Toxicology. 12: 555-9. PMID 10409393 DOI: 10.1021/Tx980248Q |
0.364 |
|
| 1999 |
Onderwater RC, Commandeur JN, Menge WM, Vermeulen NP. Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes. Chemical Research in Toxicology. 12: 396-402. PMID 10328749 DOI: 10.1021/Tx980198P |
0.382 |
|
| 1999 |
Kranendonk M, Carreira F, Theisen P, Laires A, Fisher CW, Rueff J, Estabrook RW, Vermeulen NP. Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies. Mutation Research. 441: 73-83. PMID 10224324 DOI: 10.1016/S1383-5718(99)00032-7 |
0.349 |
|
| 1999 |
de Zwart LL, Vermeulen NP, Hermanns RC, Commandeur JN, Salemink PJ, Meerman JH. Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of calcium carbimide co-administration. Chemico-Biological Interactions. 117: 151-72. PMID 10190574 DOI: 10.1016/S0009-2797(98)00106-9 |
0.373 |
|
| 1999 |
Wormhoudt LW, Commandeur JN, Vermeulen NP. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity. Critical Reviews in Toxicology. 29: 59-124. PMID 10066160 DOI: 10.1080/10408449991349186 |
0.363 |
|
| 1999 |
Kranendonk M, Fisher CW, Roda R, Carreira F, Theisen P, Laires A, Rueff J, Vermeulen NP, Estabrook RW. Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems. Mutation Research. 439: 287-300. PMID 10023085 DOI: 10.1016/S1383-5718(98)00193-4 |
0.317 |
|
| 1999 |
Kranendonk M, Mesquita P, Laires A, Vermeulen NP, Rueff J. Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens. Mutagenesis. 13: 263-9. PMID 9643585 DOI: 10.1093/Mutage/13.3.263 |
0.362 |
|
| 1998 |
Bessems JG, de Groot MJ, Baede EJ, te Koppele JM, Vermeulen NP. Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 28: 855-75. PMID 9764928 DOI: 10.1080/004982598239100 |
0.306 |
|
| 1998 |
Hermanns RC, de Zwart LL, Salemink PJ, Commandeur JN, Vermeulen NP, Meerman JH. Urinary excretion of biomarkers of oxidative kidney damage induced by ferric nitrilotriacetate. Toxicological Sciences : An Official Journal of the Society of Toxicology. 43: 241-9. PMID 9710965 DOI: 10.1006/Toxs.1998.2429 |
0.323 |
|
| 1998 |
Vermeulen NP, Commandeur JN, Groot EJ, Wormhoudt LW, Ramnatshing S, Li QJ, Brakenhoff JP. Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it. Chemico-Biological Interactions. 110: 139-58. PMID 9609383 DOI: 10.1016/S0009-2797(98)00004-0 |
0.385 |
|
| 1998 |
Onderwater RC, Commandeur JN, Groot EJ, Sitters A, Menge WM, Vermeulen NP. Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study. Toxicology. 125: 117-29. PMID 9570327 DOI: 10.1016/S0300-483X(97)00169-8 |
0.38 |
|
| 1998 |
de Zwart LL, Hermanns RC, Meerman JH, Commandeur JN, Salemink PJ, Vermeulen NP. Evaluation of urinary biomarkers for radical-induced liver damage in rats treated with carbon tetrachloride. Toxicology and Applied Pharmacology. 148: 71-82. PMID 9465266 DOI: 10.1006/Taap.1997.8310 |
0.335 |
|
| 1997 |
De Groot MJ, Vermeulen NP. Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes. Drug Metabolism Reviews. 29: 747-99. PMID 9262946 DOI: 10.3109/03602539709037596 |
0.345 |
|
| 1997 |
De Zwart LL, Venhorst J, Groot M, Commandeur JN, Hermanns RC, Meerman JH, Van Baar BL, Vermeulen NP. Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection. Journal of Chromatography. B, Biomedical Sciences and Applications. 694: 277-87. PMID 9252041 DOI: 10.1016/S0378-4347(97)00144-8 |
0.339 |
|
| 1997 |
Kranendonk M, Commandeur JN, Laires A, Rueff J, Vermeulen NP. Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100. Mutagenesis. 12: 245-54. PMID 9237769 DOI: 10.1093/Mutage/12.4.245 |
0.34 |
|
| 1997 |
van der Aar EM, de Groot MJ, Bouwman T, Bijloo GJ, Commandeur JN, Vermeulen NP. 4-Substituted 1-chloro-2-nitrobenzenes: structure-activity relationships and extension of the substrate model of rat glutathione S-transferase 4-4. Chemical Research in Toxicology. 10: 439-49. PMID 9114982 DOI: 10.1021/Tx960137W |
0.338 |
|
| 1997 |
de Groot MJ, Bijloo GJ, Martens BJ, van Acker FA, Vermeulen NP. A refined substrate model for human cytochrome P450 2D6. Chemical Research in Toxicology. 10: 41-8. PMID 9074801 DOI: 10.1021/Tx960129F |
0.335 |
|
| 1997 |
Ploemen JP, Wormhoudt LW, Haenen GR, Oudshoorn MJ, Commandeur JN, Vermeulen NP, de Waziers I, Beaune PH, Watabe T, van Bladeren PJ. The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: the case of ethylene dibromide. Toxicology and Applied Pharmacology. 143: 56-69. PMID 9073592 DOI: 10.1006/Taap.1996.8004 |
0.43 |
|
| 1997 |
Onderwater RC, Goeptar AR, Levering PR, Vos RM, Konings PN, Doehmer J, Commandeur JN, Vermeulen NP. The use of macroporous microcarriers for the large-scale growth of V79 cells genetically designed to express single human cytochrome P450 isoenzymes and for the characterization of the expressed cytochrome P450. Protein Expression and Purification. 8: 439-46. PMID 8954891 DOI: 10.1006/Prep.1996.0122 |
0.325 |
|
| 1997 |
de Zwart LL, Hermanns RC, Meerman JH, Commandeur JN, Vermeulen NP. Disposition in rat of [2-3H]-trans-4-hydroxy-2,3-nonenal, a product of lipid peroxidation. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 26: 1087-100. PMID 8905921 DOI: 10.3109/00498259609167424 |
0.352 |
|
| 1997 |
Commandeur JN, King LJ, Koymans L, Vermeulen NP. Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: indications for formation of both thionoacylating species and thiiranes as reactive intermediates. Chemical Research in Toxicology. 9: 1092-102. PMID 8902263 DOI: 10.1021/Tx960049B |
0.327 |
|
| 1997 |
de Groot MJ, Vermeulen NP, Kramer JD, van Acker FA, Donné-Op den Kelder GM. A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108. Chemical Research in Toxicology. 9: 1079-91. PMID 8902262 DOI: 10.1021/Tx960003I |
0.362 |
|
| 1997 |
van der Aar EM, Buikema D, Commandeur JN, te Koppele JM, van Ommen B, van Bladeren PJ, Vermeulen NP. Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 26: 143-55. PMID 8867999 DOI: 10.3109/00498259609046696 |
0.357 |
|
| 1997 |
van der Aar EM, de Groot MJ, Bijloo GJ, van der Goot H, Vermeulen NP. Structure-activity relationships for the glutathione conjugation of 2-substituted 1-chloro-4-nitrobenzenes by rat glutathione S-transferase 4-4. Chemical Research in Toxicology. 9: 527-34. PMID 8839058 DOI: 10.1021/Tx9501391 |
0.328 |
|
| 1996 |
Van der Aar EM, Bouwman T, Commandeur JN, Vermeulen NP. Structure-activity relationships for chemical and glutathione S-transferase-catalysed glutathione conjugation reactions of a series of 2-substituted 1-chloro-4-nitrobenzenes The Biochemical Journal. 320: Pt 2/-. PMID 8973562 DOI: 10.1042/Bj3200531 |
0.333 |
|
| 1996 |
de Groot MJ, Vermeulen NP, Mullenders DL, Donné-Op den Kelder GM. A homology model for rat mu class glutathione S-transferase 4-4. Chemical Research in Toxicology. 9: 28-40. PMID 8924604 DOI: 10.1021/Tx950082I |
0.345 |
|
| 1996 |
Wormhoudt LW, Ploemen JH, de Waziers I, Commandeur JN, Beaune PH, van Bladeren PJ, Vermeulen NP. Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes. Chemico-Biological Interactions. 101: 175-92. PMID 8870687 DOI: 10.1016/0009-2797(96)03723-4 |
0.383 |
|
| 1996 |
Bessems JG, Te Koppele JM, Van Dijk PA, Van Stee LL, Commandeur JN, Vermeulen NP. Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 26: 647-66. PMID 8810035 DOI: 10.3109/00498259609046740 |
0.376 |
|
| 1996 |
Ploemen JP, van Iersel ML, Wormhoudt LW, Commandeur JN, Vermeulen NP, van Bladeren PJ. In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate. Biochemical Pharmacology. 52: 197-204. PMID 8694843 DOI: 10.1016/0006-2952(96)00142-6 |
0.383 |
|
| 1996 |
Andreadou I, Menge WM, Commandeur JN, Worthington EA, Vermeulen NP. Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of beta-elimination reactions in rat renal cytosol. Journal of Medicinal Chemistry. 39: 2040-6. PMID 8642562 DOI: 10.1021/Jm950750X |
0.318 |
|
| 1996 |
Brakenhoff JP, Commandeur JN, Wormhoudt LW, Groot EJ, Vermeulen NP. Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions. Carcinogenesis. 17: 715-24. PMID 8625482 DOI: 10.1093/Carcin/17.4.715 |
0.385 |
|
| 1996 |
Wormhoudt LW, Ploemen JH, Commandeur JN, van Ommen B, van Bladeren P, Vermeulen NP. Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats. Chemico-Biological Interactions. 99: 41-53. PMID 8620578 DOI: 10.1016/0009-2797(95)03659-8 |
0.397 |
|
| 1996 |
Oetari S, Sudibyo M, Commandeur JN, Samhoedi R, Vermeulen NP. Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver. Biochemical Pharmacology. 51: 39-45. PMID 8534266 DOI: 10.1016/0006-2952(95)02113-2 |
0.376 |
|
| 1996 |
Andreadou I, van de Wate B, Commandeur JN, Nagelkerke FJ, Vermeulen NP. Comparative cytotoxicity of 14 novel selenocysteine Se-conjugatesin rat renal proximal tubular cells Toxicology and Applied Pharmacology. 141: 278-287. DOI: 10.1016/S0041-008X(96)80034-2 |
0.326 |
|
| 1995 |
Goeptar AR, Scheerens H, Vermeulen NP. Oxygen and xenobiotic reductase activities of cytochrome P450. Critical Reviews in Toxicology. 25: 25-65. PMID 7734059 DOI: 10.3109/10408449509089886 |
0.342 |
|
| 1995 |
Goeptar AR, Commandeur JN, van Ommen B, van Bladeren PJ, Vermeulen NP. Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway. Chemical Research in Toxicology. 8: 3-21. PMID 7703363 DOI: 10.1021/Tx00043A001 |
0.316 |
|
| 1995 |
Goeptar AR, te Koppele JM, Glatt HR, Groot EJ, Seidel A, Barrenscheen M, Wölfel C, Doehmer J, Vermeulen NP. The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes. Chemico-Biological Interactions. 97: 149-68. PMID 7606813 DOI: 10.1016/0009-2797(95)03611-O |
0.304 |
|
| 1995 |
de Groot MJ, Donné-Op den Kelder GM, Commandeur JN, van Lenthe JH, Vermeulen NP. Metabolite predictions for para-substituted anisoles based on ab initio complete active space self-consistent field calculations. Chemical Research in Toxicology. 8: 437-43. PMID 7578931 DOI: 10.1021/Tx00045A016 |
0.344 |
|
| 1994 |
Yamauchi A, Stijntjes GJ, Commandeur JN, Vermeulen NP. Purification of glutamine transaminase K/cysteine conjugate beta-lyase from rat renal cytosol based on hydrophobic interaction HPLC and gel permeation FPLC. Protein Expression and Purification. 4: 552-62. PMID 8286953 DOI: 10.1006/Prep.1993.1073 |
0.338 |
|
| 1994 |
Brakenhoff JP, Commandeur JN, Lamorée MH, Dubelaar AC, van Baar BL, Lucas C, Vermeulen NP. Identification and quantitative determination of glutathione-related urinary metabolites of fotemustine, a new anti-cancer agent. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 23: 935-47. PMID 8284948 DOI: 10.3109/00498259309059420 |
0.336 |
|
| 1994 |
Brakenhoff JP, Commandeur JN, de Kanter FJ, van Baar BL, Luijten WC, Vermeulen NP. Chemical and glutathione conjugation-related degradation of fotemustine: formation and characterization of a glutathione conjugate of diethyl (1-isocyanatoethyl)phosphonate, a reactive metabolite of fotemustine. Chemical Research in Toxicology. 7: 380-9. PMID 8075370 DOI: 10.1021/Tx00039A016 |
0.421 |
|
| 1994 |
Remirez D, Commandeur J, Groot E, Vermeulen N. Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocytes Toxicology Letters. 74: 68. DOI: 10.1016/0926-6917(95)90049-7 |
0.41 |
|
| 1994 |
Qiu-Ju L, Bessems JG, Commandeur JN, Adams B, Vermeulen NP. Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes Biochemical Pharmacology. 48: 1631-1640. DOI: 10.1016/0006-2952(94)90208-9 |
0.376 |
|
| 1993 |
Koymans L, Donné-op den Kelder GM, Koppele Te JM, Vermeulen NP. Cytochromes P450: their active-site structure and mechanism of oxidation. Drug Metabolism Reviews. 25: 325-87. PMID 8404461 DOI: 10.3109/03602539308993979 |
0.312 |
|
| 1993 |
Koymans L, Donné-Op den Kelder GM, te Koppele JM, Vermeulen NP. Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 23: 633-48. PMID 8212737 DOI: 10.3109/00498259309059401 |
0.344 |
|
| 1992 |
Baldew GS, Boymans AP, Mol JG, Vermeulen NP. The influence of ebselen on the toxicity of cisplatin in LLC-PK1 cells. Biochemical Pharmacology. 44: 382-7. PMID 1642650 DOI: 10.1016/0006-2952(92)90024-D |
0.317 |
|
| 1992 |
Vermeulen NP, Baldew GS. The role of lipid peroxidation in the nephrotoxicity of cisplatin. Biochemical Pharmacology. 44: 1193-9. PMID 1417941 DOI: 10.1016/0006-2952(92)90384-U |
0.317 |
|
| 1992 |
Koymans L, Vermeulen NP, van Acker SA, te Koppele JM, Heykants JJ, Lavrijsen K, Meuldermans W, Donné-Op den Kelder GM. A predictive model for substrates of cytochrome P450-debrisoquine (2D6). Chemical Research in Toxicology. 5: 211-9. PMID 1379482 DOI: 10.1021/Tx00026A010 |
0.314 |
|
| 1992 |
Goeptar AR, Te Koppele JM, Neve EP, Vermeulen NP. Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate. Chemico-Biological Interactions. 83: 249-69. PMID 1325294 DOI: 10.1016/0009-2797(92)90101-P |
0.36 |
|
| 1992 |
Goeptar AR, te Koppele JM, van Maanen JM, Zoetemelk CE, Vermeulen NP. One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450. Biochemical Pharmacology. 43: 343-52. PMID 1310854 DOI: 10.1016/0006-2952(92)90297-V |
0.377 |
|
| 1991 |
Koymans L, van Lenthe JH, van de Straat R, Donné-Op den Kelder GM, Vermeulen NP. A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism. Chemical Research in Toxicology. 2: 60-6. PMID 2519233 DOI: 10.1021/Tx00007A011 |
0.322 |
|
| 1991 |
Commandeur JN, Stijntjes GJ, Wijngaard J, Vermeulen NP. Metabolism of L-cysteine S-conjugates and N-(trideuteroacetyl)-L-cysteine S-conjugates of four fluoroethylenes in the rat. Role of balance of deacetylation and acetylation in relation to the nephrotoxicity of mercapturic acids. Biochemical Pharmacology. 42: 31-8. PMID 2069595 DOI: 10.1016/0006-2952(91)90677-W |
0.361 |
|
| 1991 |
Baldew GS, Mol JG, de Kanter FJ, van Baar B, de Goeij JJ, Vermeulen NP. The mechanism of interaction between cisplatin and selenite. Biochemical Pharmacology. 41: 1429-37. PMID 2018551 DOI: 10.1016/0006-2952(91)90558-M |
0.32 |
|
| 1991 |
Commandeur JN, Vermeulen NP. Identification of N-acetyl(2,2-dichlorovinyl)- and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat. Chemical Research in Toxicology. 3: 212-8. PMID 1966701 DOI: 10.1021/Tx00015A005 |
0.368 |
|
| 1991 |
Commandeur JN, Boogaard PJ, Mulder GJ, Vermeulen NP. Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene. Archives of Toxicology. 65: 373-80. PMID 1929851 DOI: 10.1007/Bf02284259 |
0.324 |
|
| 1991 |
van Welie RT, van Duyn P, Lamme EK, Jäger P, van Baar BL, Vermeulen NP. Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans. International Archives of Occupational and Environmental Health. 63: 181-6. PMID 1917068 DOI: 10.1007/Bf00381566 |
0.357 |
|
| 1991 |
Wilbrink M, Groot EJ, Jansen R, De Vries Y, Vermeulen NP. Occurrence of a cytochrome P-450-containing mixed-function oxidase system in the pond snail, Lymnaea stagnalis. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 21: 223-33. PMID 1905437 DOI: 10.3109/00498259109039464 |
0.367 |
|
| 1991 |
Haenen GR, Jansen FP, Vermeulen NP, Bast A. Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa. Archives of Biochemistry and Biophysics. 287: 48-52. PMID 1897994 DOI: 10.1016/0003-9861(91)90386-W |
0.361 |
|
| 1991 |
van Welie RT, van Marrewijk CM, de Wolff FA, Vermeulen NP. Thioether excretion in urine of applicators exposed to 1,3-dichloropropene: a comparison with urinary mercapturic acid excretion. British Journal of Industrial Medicine. 48: 492-8. PMID 1854651 DOI: 10.1136/Oem.48.7.492 |
0.323 |
|
| 1990 |
Haenen GR, Vermeulen NP, Timmerman H, Bast A. Effect of thiols on lipid peroxidation in rat liver microsomes. Chemico-Biological Interactions. 71: 201-12. PMID 2598297 DOI: 10.1016/0009-2797(89)90035-5 |
0.319 |
|
| 1990 |
Donatus IA, Vermeulen NP. Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes. Biochemical Pharmacology. 39: 1869-75. PMID 2353930 DOI: 10.1016/0006-2952(90)90603-I |
0.354 |
|
| 1990 |
Vromans RM, van de Straat R, Groeneveld M, Vermeulen NP. One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 20: 967-78. PMID 2122607 DOI: 10.3109/00498259009046912 |
0.358 |
|
| 1989 |
Commandeur JN, Brakenhoff JP, De Kanter FJ, Vermeulen NP. Nephrotoxicity of mercapturic acids of three structurally related 2,2-difluoroethylenes in the rat. Indications for different bioactivation mechanisms. Biochemical Pharmacology. 37: 4495-504. PMID 3202890 DOI: 10.1016/0006-2952(88)90665-X |
0.349 |
|
| 1989 |
Vermeulen NP, de Jong J, van Bergen EJ, van Welie RT. N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies? A critical evaluation of possibilities and limitations. Archives of Toxicology. 63: 173-84. PMID 2669681 DOI: 10.1007/Bf00316366 |
0.342 |
|
| 1988 |
Commandeur JN, Oostendorp RA, Schoofs PR, Xu B, Vermeulen NP. Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat. Indications for differential mechanisms of bioactivation. Biochemical Pharmacology. 36: 4229-37. PMID 3689448 DOI: 10.1016/0006-2952(87)90663-0 |
0.397 |
|
| 1988 |
Haenen GR, Tai Tin Tsoi JN, Vermeulen NP, Timmerman H, Bast A. 4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection. Archives of Biochemistry and Biophysics. 259: 449-56. PMID 3426239 DOI: 10.1016/0003-9861(87)90511-X |
0.321 |
|
| 1988 |
Haenen GR, Vermeulen NP, Tai Tin Tsoi JN, Ragetli HM, Timmerman H, Blast A. Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein. Biochemical Pharmacology. 37: 1933-8. PMID 3377801 DOI: 10.1016/0006-2952(88)90539-4 |
0.305 |
|
| 1988 |
Joeres RP, Vermeulen NP, Breimer DD. Influence of the rate of hepatic portal vein infusion on hexobarbital pharmacokinetics in the rat. Pharmacology. 36: 210-6. PMID 3368506 DOI: 10.1159/000138386 |
0.507 |
|
| 1988 |
van de Straat R, Vromans RM, Bosman P, de Vries J, Vermeulen NP. Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol. Chemico-Biological Interactions. 64: 267-80. PMID 3342453 DOI: 10.1016/0009-2797(88)90102-0 |
0.336 |
|
| 1988 |
Burm AG, de Boer AG, van Kleef JW, Vermeulen NP, de Leede LG, Spierdijk J, Breimer DD. Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: a study in healthy volunteers. Biopharmaceutics & Drug Disposition. 9: 85-95. PMID 3342287 DOI: 10.1002/Bod.2510090109 |
0.422 |
|
| 1988 |
Burm AG, Van Kleef JW, Vermeulen NP, Olthof G, Breimer DD, Spierdijk J. Pharmacokinetics of lidocaine and bupivacaine following subarachnoid administration in surgical patients: simultaneous investigation of absorption and disposition kinetics using stable isotopes. Anesthesiology. 69: 584-92. PMID 3177919 DOI: 10.1097/00000542-198810000-00020 |
0.425 |
|
| 1988 |
van der Graaff M, Vermeulen NP, Breimer DD. Disposition of hexobarbital: 15 years of an intriguing model substrate. Drug Metabolism Reviews. 19: 109-64. PMID 3069420 DOI: 10.3109/03602538809049621 |
0.443 |
|
| 1987 |
van de Straat R, de Vries J, de Boer HJ, Vromans RM, Vermeulen NP. Relationship between paracetamol binding to and its oxidation by two cytochromes P-450 isozymes--a proton nuclear magnetic resonance and spectrophotometric study. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 17: 1-9. PMID 3825173 DOI: 10.3109/00498258709047169 |
0.329 |
|
| 1987 |
Burm AG, Vermeulen NP, van Kleef JW, de Boer AG, Spierdijk J, Breimer DD. Pharmacokinetics of lignocaine and bupivacaine in surgical patients following epidural administration. Simultaneous investigation of absorption and disposition kinetics using stable isotopes. Clinical Pharmacokinetics. 13: 191-203. PMID 3665324 DOI: 10.2165/00003088-198713030-00004 |
0.412 |
|
| 1987 |
van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. Correlation of apparent intrinsic clearances of simultaneously administered S (+) and d3R (-) hexobarbital in the rat. Biochemical Pharmacology. 36: 1321-3. PMID 3593417 DOI: 10.1016/0006-2952(87)90088-8 |
0.458 |
|
| 1987 |
van de Straat R, de Vries J, Vermeulen NP. Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen. Biochemical Pharmacology. 36: 613-9. PMID 3030331 DOI: 10.1016/0006-2952(87)90710-6 |
0.351 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Heij P, de Bree H, Breimer DD. Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 16: 1091-6. PMID 3798956 DOI: 10.3109/00498258609038986 |
0.527 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Vinks MH, Breimer DD. Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat. European Journal of Drug Metabolism and Pharmacokinetics. 11: 107-11. PMID 3770011 DOI: 10.1007/Bf03189835 |
0.514 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Koperdraat MC, Breimer DD. Non-linear pharmacokinetics of sparteine in the rat. Archives Internationales De Pharmacodynamie Et De ThéRapie. 282: 181-95. PMID 3767526 |
0.462 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Heij P, Boeijinga JK, Breimer DD. Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects. Biopharmaceutics & Drug Disposition. 7: 265-72. PMID 3730526 DOI: 10.1002/Bdd.2510070307 |
0.428 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Breimer DD. Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio. Pharmaceutisch Weekblad. Scientific Edition. 8: 139-44. PMID 3714437 DOI: 10.1007/Bf02086148 |
0.457 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. Stereospecific analysis of racemic hexobarbital in rat blood by enantioselective capillary gas chromatography. Journal of Chromatography. 375: 411-5. PMID 3700566 DOI: 10.1016/S0378-4347(00)83736-6 |
0.407 |
|
| 1986 |
van der Graaff M, Vermeulen NP, Hofman PH, Breimer DD. The influence of pretreatment on the urinary metabolite profile of pseudoracemic hexobarbital. Biochemical Pharmacology. 35: 3166-9. PMID 3092834 DOI: 10.1016/0006-2952(86)90404-1 |
0.503 |
|
| 1986 |
Van der Graaff M, Vermeulen NP, Crul IE, Breimer DD. Dose-dependent pharmacokinetics of zoxazolamine in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 14: 331-5. PMID 2872034 |
0.426 |
|
| 1985 |
Teunissen MW, Kampf D, Roots I, Vermeulen NP, Breimer DD. Antipyrine metabolite formation and excretion in patients with chronic renal failure. European Journal of Clinical Pharmacology. 28: 589-95. PMID 4043202 DOI: 10.1007/Bf00544072 |
0.449 |
|
| 1985 |
van der Graaff M, Hofman PH, Breimer DD, Vermeulen NP, Knabe J, Schamber L. Selected ion monitoring analysis of pseudoracemic hexobarbital and its major metabolites in blood and urine of rats. Biomedical Mass Spectrometry. 12: 464-9. PMID 2932174 DOI: 10.1002/Bms.1200120904 |
0.447 |
|
| 1985 |
Van der Graaff M, Vermeulen NP, Breimer DD. Route- and dose-dependent pharmacokinetics of hexobarbitone in the rat: a re-evaluation of the use of sleeping times in metabolic studies. The Journal of Pharmacy and Pharmacology. 37: 550-4. PMID 2864415 DOI: 10.1111/J.2042-7158.1985.Tb03065.X |
0.475 |
|
| 1984 |
Kleinbloesem CH, van Brummelen P, Faber H, Danhof M, Vermeulen NP, Breimer DD. Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man. Biochemical Pharmacology. 33: 3721-4. PMID 6508829 |
0.379 |
|
| 1984 |
van der Graaff M, Vermeulen NP, Joeres RP, Breimer DD. Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt. Pharmacology. 29: 99-109. PMID 6473507 DOI: 10.1159/000137998 |
0.499 |
|
| 1983 |
Vermeulen NP, Danhof M, Setiawan I, Breimer DD. Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia. The Journal of Pharmacology and Experimental Therapeutics. 226: 201-5. PMID 6864540 |
0.488 |
|
| 1983 |
Vermeulen NP, Rietveld CT, Breimer DD. Disposition of hexobarbitone in healthy man: kinetics of parent drug and metabolites following oral administration. British Journal of Clinical Pharmacology. 15: 459-64. PMID 6849782 |
0.448 |
|
| 1983 |
Teunissen MW, Meerburg-van der Torren JE, Vermeulen NP, Breimer DD. Automated high-performance liquid chromatographic determination of antipyrine and its main metabolites in plasma, saliva and urine, including 4,4'-dihydroxyantipyrine. Journal of Chromatography. 278: 367-78. PMID 6668316 |
0.455 |
|
| 1983 |
Teunissen MW, Van Graft M, Vermeulen NP, Breimer DD. Influence of allylisopropylacetamide and phenobarbital treatment on in vivo antipyrine metabolite formation in rats. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 13: 497-502. PMID 6649682 DOI: 10.3109/00498258309052289 |
0.519 |
|
| 1983 |
van der Graaff M, Vermeulen NP, Joeres RP, Vlietstra T, Breimer DD. Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats. The Journal of Pharmacology and Experimental Therapeutics. 227: 459-65. PMID 6631725 |
0.489 |
|
| 1983 |
Teunissen MW, Joeres RP, Vermeulen NP, Breimer DD. Influence of 9-hydroxyellipticine and 3-methylcholanthrene treatment on antipyrine metabolite formation in rats in vivo. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 13: 223-31. PMID 6624137 DOI: 10.3109/00498258309052258 |
0.518 |
|
| 1983 |
van der Graaff M, Vermeulen NP, Joeres RP, Breimer DD. Disposition of hexobarbital enantiomers in the rat. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 11: 489-93. PMID 6138236 |
0.473 |
|
| 1983 |
van der Graaff M, Vermeulen NP, Langendijk PN, Breimer DD. Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies. The Journal of Pharmacology and Experimental Therapeutics. 225: 747-51. PMID 6134816 |
0.51 |
|
| 1981 |
van Bladeren PJ, Breimer DD, van Huijgevoort JA, Vermeulen NP, van der Gen A. The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo. Biochemical Pharmacology. 30: 2499-502. PMID 21043256 |
0.455 |
|
| 1981 |
Heusler H, Epping J, Heusler S, Richter E, Vermeulen NP, Breimer DD. Simultaneous determination of blood concentrations of methohexital and its hydroxy metabolite by gas chromatography and identification of 4'-hydroxymethohexital by combined gas--liquid chromatography--mass spectrometry. Journal of Chromatography. 226: 403-12. PMID 7320169 |
0.464 |
|
| 1981 |
Vermeulen NP, Breimer DD, Holthuis J, Mol C, Bakker BH, van der Gen A. The metabolic fate of 1',2'-epoxyhexobarbital in the rat. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 11: 547-57. PMID 7029928 DOI: 10.3109/00498258109045866 |
0.52 |
|
| 1981 |
Vermeulen NP, Bakker BH, Eylers D, Breimer DD. The epoxide-diol pathway in the metabolism of vinylbital in rat and man. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 10: 159-68. PMID 6110286 DOI: 10.3109/00498258009033742 |
0.515 |
|
| 1980 |
Vermeulen NP, Teunissen MW, Breimer DD. Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration. British Journal of Clinical Pharmacology. 8: 459-63. PMID 508551 DOI: 10.1111/J.1365-2125.1979.TB01026.X |
0.44 |
|
| 1979 |
Vermeulen NP, Bakker BH, Schultink J, van der Gen A, Breimer DD. The epoxide-diol pathway in the metabolism of hexobarbital in rat and man. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 9: 289-99. PMID 494660 DOI: 10.3109/00498257909038732 |
0.455 |
|
| 1978 |
Vermeulen NP, Teunissen MW, Breimer DD. Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection. Journal of Chromatography. 157: 133-40. PMID 701438 DOI: 10.1016/S0021-9673(00)92329-X |
0.438 |
|
| 1978 |
Vermeulen NP, van Bladeren PJ, Breimer DD, van der Gen A. Hexobarbital-1',2'-epoxide: a possible intermediate in the metabolism of hexobarbital. Biochemical Pharmacology. 27: 135-8. PMID 619900 DOI: 10.1016/0006-2952(78)90274-5 |
0.434 |
|
| 1977 |
Vermeulen NP, de Roode D, Breimer DD. Gas chromatographic determination of pemoline as 5-phenyl-2,4-oxazolidinedione in human urine. Journal of Chromatography. 137: 333-42. PMID 881457 DOI: 10.1016/S0021-9673(00)81356-4 |
0.438 |
|
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