Hermen S. Overkleeft - Publications

Affiliations: 
chemistry Leiden University, Leiden, Netherlands 
Website:
https://www.leidenuniv.nl/nieuwsarchief2/2393.html

365 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mieremet A, Boiten W, van Dijk R, Gooris G, Overkleeft HS, Aerts JMFG, Bouwstra JA, El Ghalbzouri A. Unravelling effects of relative humidity on lipid barrier formation in human skin equivalents. Archives of Dermatological Research. PMID 31321505 DOI: 10.1007/s00403-019-01948-3  1
2019 Moiola M, Bova A, Crespi S, Memeo MG, Mella M, Overkleeft HS, Florea BI, Quadrelli P. Fluorescent Probes from Aromatic Polycyclic Nitrile Oxides: Isoxazoles versus Dihydro-1λ,3,2λ-Oxazaborinines. Chemistryopen. 8: 770-780. PMID 31289713 DOI: 10.1002/open.201900137  1
2019 van der Vorm S, Hansen T, van Hengst JMA, Overkleeft HS, van der Marel GA, Codée JDC. Acceptor reactivity in glycosylation reactions. Chemical Society Reviews. PMID 31287452 DOI: 10.1039/c8cs00369f  1
2019 Schröder SP, de Boer C, McGregor NGS, Rowland RJ, Moroz O, Blagova E, Reijngoud J, Arentshorst M, Osborn D, Morant MD, Abbate E, Stringer MA, Krogh KBRM, Raich L, Rovira C, ... ... Overkleeft HS, et al. Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Secretomes Using Activity-Based Probes. Acs Central Science. 5: 1067-1078. PMID 31263766 DOI: 10.1021/acscentsci.9b00221  1
2019 Hansen T, Lebedel L, Remmerswaal WA, van der Vorm S, Wander DPA, Somers M, Overkleeft HS, Filippov DV, Désiré J, Mingot A, Bleriot Y, van der Marel GA, Thibaudeau S, Codée JDC. Defining the S1 Side of Glycosylation Reactions: Stereoselectivity of Glycopyranosyl Cations. Acs Central Science. 5: 781-788. PMID 31139714 DOI: 10.1021/acscentsci.9b00042  1
2019 Wang L, Overkleeft HS, van der Marel GA, Codée JDC. Reagent Controlled Stereoselective Assembly of α-(1,3)-Glucans. European Journal of Organic Chemistry. 2019: 1994-2003. PMID 31007571 DOI: 10.1002/ejoc.201800894  1
2019 Gential GPP, Hogervorst TP, Tondini E, van de Graaff MJ, Overkleeft HS, Codée JDC, van der Marel GA, Ossendorp F, Filippov DV. Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7. Bioorganic & Medicinal Chemistry Letters. PMID 30952595 DOI: 10.1016/j.bmcl.2019.03.048  1
2019 van Meel E, Bos E, van der Lienden MJC, Overkleeft HS, van Kasteren SI, Koster AJ, Aerts JMFG. Localization of Active Endogenous and Exogenous GBA by Correlative Light-Electron Microscopy in Human Fibroblasts. Traffic (Copenhagen, Denmark). PMID 30895685 DOI: 10.1111/tra.12641  1
2019 van der Vorm S, Hansen T, van Rijssel ER, Dekkers R, Madern JM, Overkleeft HS, Filippov DV, van der Marel GA, Codée JDC. Furanosyl oxocarbenium ion Conformational Energy Landscape maps as a tool to study the glycosylation stereoselectivity of 2-azidofuranoses, 2-fluorofuranoses and methyl furanosyl uronates. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30882938 DOI: 10.1002/chem.201900651  1
2019 Zom GG, Willems MMJHP, Meeuwenoord N, Reintjens NRM, Tondini E, Khan S, Overkleeft HS, van der Marel GA, Codée JDC, Ossendorp F, Filippov DV. Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells. Bioconjugate Chemistry. PMID 30865430 DOI: 10.1021/acs.bioconjchem.9b00087  1
2019 Artola M, Kuo CL, Lelieveld LT, Rowland RJ, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS. Functionalized cyclophellitols are selective glucocerebrosidase inhibitors and induce a bona fide neuropathic Gaucher model in zebrafish. Journal of the American Chemical Society. PMID 30811188 DOI: 10.1021/jacs.9b00056  1
2019 Grimm SH, Gagestein B, Keijzer JF, Liu N, Wijdeven RH, Lenselink EB, Tuin AW, van den Nieuwendijk AMCH, van Westen GJP, van Boeckel CAA, Overkleeft HS, Neefjes J, van der Stelt M. Comprehensive structure-activity-relationship of azaindoles as highly potent FLT3 inhibitors. Bioorganic & Medicinal Chemistry. PMID 30661740 DOI: 10.1016/j.bmc.2019.01.006  1
2019 Xin BT, Huber E, de Bruin G, Heinemeyer W, Maurits E, Espinal C, Du Y, Janssens M, Weyburne ES, Kisselev A, Florea BI, Driessen C, van der Marel GA, Groll M, Overkleeft HS. Structure-based design of inhibitors selective for human proteasome β2c or β2i subunits. Journal of Medicinal Chemistry. PMID 30657666 DOI: 10.1021/acs.jmedchem.8b01884  1
2019 Zhou J, Mock ED, Martella A, Kantae V, Di X, Burggraaff L, Baggelaar MP, Al-Ayed K, Bakker A, Florea BI, Grimm SH, den Dulk H, Li CT, Mulder L, Overkleeft HS, et al. Activity-based protein profiling identifies α-ketoamides as inhibitors for Phospholipase A2 Group XVI. Acs Chemical Biology. PMID 30620559 DOI: 10.1021/acschembio.8b00969  1
2019 Madern JM, Hansen T, van Rijssel ER, Kistemaker HAV, van der Vorm S, Overkleeft HS, van der Marel GA, Filippov DV, Codée JDC. Synthesis, reactivity and stereoselectivity of 4-thiofuranosides. The Journal of Organic Chemistry. PMID 30605336 DOI: 10.1021/acs.joc.8b02536  1
2019 Kuo CL, Kallemeijn WW, Lelieveld LT, Mirzaian M, Zoutendijk I, Vardi A, Futerman AH, Meijer AH, Spaink HP, Overkleeft HS, Aerts JMFG, Artola M. In vivo inactivation of glycosidases by conduritol B epoxide and cyclophellitol as revealed by activity-based protein profiling. The Febs Journal. PMID 30600575 DOI: 10.1111/febs.14744  1
2019 Steverding D, Florea BI, Overkleeft HS. Trypanosoma brucei: β2-selective proteasome inhibitors do not block the proteasomal trypsin-like activity but are trypanocidal. Molecular and Biochemical Parasitology. 227: 1-4. PMID 30444977 DOI: 10.1016/j.molbiopara.2018.11.002  1
2018 Besse A, Besse L, Kraus M, Mendez-Lopez M, Bader J, Xin BT, de Bruin G, Maurits E, Overkleeft HS, Driessen C. Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors. Cell Chemical Biology. PMID 30612952 DOI: 10.1016/j.chembiol.2018.11.007  1
2018 Rugen MD, Vernet MMJL, Hantouti L, Soenens A, Andriotis VME, Rejzek M, Brett P, van den Berg RJBHN, Aerts JMFG, Overkleeft HS, Field RA. A chemical genetic screen reveals that iminosugar inhibitors of plant glucosylceramide synthase inhibit root growth in Arabidopsis and cereals. Scientific Reports. 8: 16421. PMID 30401902 DOI: 10.1038/s41598-018-34749-1  1
2018 Artola M, Kuo CL, McMahon SA, Oehler V, Hansen T, van der Lienden M, He X, van den Elst H, Florea BI, Kermode AR, Gloster TM, van der Marel GA, Codée JDC, Overkleeft HS, Aerts JMFG. New irreversible α-L-iduronidase inhibitors and activity-based probes. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30307091 DOI: 10.1002/chem.201804662  1
2018 Basler M, Lindstrom MM, LaStant JJ, Bradshaw JM, Owens TD, Schmidt C, Maurits E, Tsu C, Overkleeft HS, Kirk CJ, Langrish CL, Groettrup M. Co-inhibition of immunoproteasome subunits LMP2 and LMP7 is required to block autoimmunity. Embo Reports. PMID 30279279 DOI: 10.15252/embr.201846512  1
2018 Ben Bdira F, Artola M, Overkleeft HS, Ubbink M, Aerts JMFG. Distinguishing the differences in β-glycosylceramidase folds, dynamics, and actions informs therapeutic uses. Journal of Lipid Research. 59: 2262-2276. PMID 30279220 DOI: 10.1194/jlr.R086629  1
2018 Downey-Kopyscinski S, Daily EW, Gautier M, Bhatt A, Florea BI, Mitsiades CS, Richardson PG, Driessen C, Overkleeft HS, Kisselev AF. An inhibitor of proteasome β2 sites sensitizes myeloma cells to immunoproteasome inhibitors. Blood Advances. 2: 2443-2451. PMID 30266819 DOI: 10.1182/bloodadvances.2018016360  1
2018 Sarris AJ, Hansen T, de Geus MA, Maurits E, Doelman W, Overkleeft HS, Codee JD, Filippov D, van Kasteren SI. Fast and pH independent elimination of trans-cyclooctene using aminoethyl functionalized tetrazines. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30184286 DOI: 10.1002/chem.201803839  1
2018 van Rooden EJ, van Esbroeck ACM, Baggelaar MP, Deng H, Florea BI, Marques ARA, Ottenhoff R, Boot RG, Overkleeft HS, Aerts JMFG, van der Stelt M. Chemical Proteomic Analysis of Serine Hydrolase Activity in Niemann-Pick Type C Mouse Brain. Frontiers in Neuroscience. 12: 440. PMID 30018533 DOI: 10.3389/fnins.2018.00440  1
2018 Voorneveld J, Rack JGM, Ahel I, Overkleeft HS, van der Marel GA, Filippov DV. Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer. Organic Letters. PMID 29947522 DOI: 10.1021/acs.orglett.8b01742  1
2018 van Rooden EJ, Kohsiek M, Kreekel R, van Esbroeck ACM, van den Nieuwendijk AMCH, Janssen APA, van den Berg RJBHN, Overkleeft HS, van der Stelt M. Design and Synthesis of Quenched Activity-based Probes for Diacylglycerol Lipase and α,β-Hydrolase Domain Containing Protein 6. Chemistry, An Asian Journal. PMID 29901868 DOI: 10.1002/asia.201800452  1
2018 Eising S, Xin BT, Kleinpenning F, Heming J, Florea B, Overkleeft H, Bonger KM. Coordination-Assisted Bioorthogonal Chemistry: Orthogonal Tetrazine Ligation with Vinylboronic Acid and a Strained Alkene. Chembiochem : a European Journal of Chemical Biology. PMID 29806887 DOI: 10.1002/cbic.201800275  1
2018 Schröder SP, Kallemeijn WW, Debets MF, Sobala LF, Hakki Z, Williams SJ, Beenakker TJM, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS. Spiro-epoxyglycosides as activity-based probes for glycoside hydrolase family 99 endomannosidase/endomannanase. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29797675 DOI: 10.1002/chem.201801902  1
2018 van der Gracht AMF, de Geus MAR, Camps MGM, Ruckwardt TJ, Sarris AJC, Bremmers J, Maurits E, Pawlak JB, Posthoorn MM, Bonger KM, Filippov DV, Overkleeft HS, Robillard MS, Ossendorp F, van Kasteren SI. Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes. Acs Chemical Biology. PMID 29733186 DOI: 10.1021/acschembio.8b00155  1
2018 Bakkum T, van Leeuwen T, Sarris AJC, van Elsland DM, Poulcharidis D, Overkleeft HS, van Kasteren SI. Quantification of Bioorthogonal Stability in Immune Phagocytes Using Flow Cytometry Reveals Rapid Degradation of Strained Alkynes. Acs Chemical Biology. PMID 29693370 DOI: 10.1021/acschembio.8b00355  1
2018 van der Vorm S, van Hengst JMA, Bakker M, Overkleeft HS, van der Marel GA, Codée J. Mapping Glycosyl Acceptor Reactivity - Glycosylation Stereoselectivity Relationships. Angewandte Chemie (International Ed. in English). PMID 29603532 DOI: 10.1002/anie.201802899  1
2018 Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS. Gluco-1H-imidazole: a new class of azole-type β-glucosidase inhibitor. Journal of the American Chemical Society. PMID 29601200 DOI: 10.1021/jacs.8b02399  1
2018 van Rooden EJ, Florea BI, Deng H, Baggelaar MP, van Esbroeck ACM, Zhou J, Overkleeft HS, van der Stelt M. Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification. Nature Protocols. 13: 752-767. PMID 29565900 DOI: 10.1038/nprot.2017.159  1
2018 Husaini AM, Morimoto K, Chandrasekar B, Kelly S, Kaschani F, Palmero D, Jiang J, Kaiser M, Ahrazem O, Overkleeft HS, van der Hoorn RAL. Multiplex fluorescent, activity-based protein profiling identifies active α-glycosidases and other hydrolases in plants. Plant Physiology. PMID 29555787 DOI: 10.1104/pp.18.00250  1
2018 Wang L, Overkleeft HS, van der Marel GA, Codée JDC. Reagent controlled stereoselective synthesis of α-glucans. Journal of the American Chemical Society. PMID 29553729 DOI: 10.1021/jacs.8b00669  1
2018 Soethoudt M, Stolze SC, Westphal MV, van Stralen L, Martella A, van Rooden EJ, Guba W, Varga ZV, Deng H, van Kasteren SI, Grether U, IJzerman AP, Pacher P, Carreira EM, Overkleeft HS, et al. A selective photoaffinity probe enables assessment of cannabinoid CB2 receptor expression and ligand engagement in human cells. Journal of the American Chemical Society. PMID 29420021 DOI: 10.1021/jacs.7b11281  1
2018 van der Es D, Berni F, Hogendorf WFJ, Meeuwenoord N, Laverde D, van Diepen A, Overkleeft HS, Filippov DV, Hokke CH, Huebner J, van der Marel GA, Codée J. Streamlined synthesis and evaluation of teichoic acid fragments. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29389054 DOI: 10.1002/chem.201800153  1
2018 Kuo CL, van Meel E, Kytidou K, Kallemeijn WW, Witte M, Overkleeft HS, Artola ME, Aerts JM. Activity-Based Probes for Glycosidases: Profiling and Other Applications. Methods in Enzymology. 598: 217-235. PMID 29306436 DOI: 10.1016/bs.mie.2017.06.039  1
2018 Basler M, Maurits E, de Bruin G, Koerner J, Overkleeft HS, Groettrup M. Amelioration of autoimmunity with an inhibitor selectively targeting all active centres of the immunoproteasome. British Journal of Pharmacology. 175: 38-52. PMID 29034459 DOI: 10.1111/bph.14069  1
2017 Deng H, van der Wel T, van den Berg RJBHN, van den Nieuwendijk AMCH, Janssen FJ, Baggelaar MP, Overkleeft HS, van der Stelt M. Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors. Medchemcomm. 8: 982-988. PMID 30108813 DOI: 10.1039/c7md00029d  1
2017 Tsakiri EN, Terpos E, Papanagnou ED, Kastritis E, Brieudes V, Halabalaki M, Bagratuni T, Florea BI, Overkleeft HS, Scorrano L, Skaltsounis AL, Dimopoulos MA, Trougakos IP. Milder degenerative effects of Carfilzomib vs. Bortezomib in the Drosophila model: a link to clinical adverse events. Scientific Reports. 7: 17802. PMID 29259189 DOI: 10.1038/s41598-017-17596-4  1
2017 Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort G, Filippov DV. A General Approach Towards Triazole-linked Adenosine Diphosphate Ribosylated Peptides and Proteins. Angewandte Chemie (International Ed. in English). PMID 29215186 DOI: 10.1002/anie.201710527  1
2017 Baker YR, Hodgkinson JT, Florea BI, Alza E, Galloway WRJD, Grimm L, Geddis SM, Overkleeft HS, Welch M, Spring DR. Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes. Chemical Science. 8: 7403-7411. PMID 29163891 DOI: 10.1039/c7sc01270e  1
2017 Geert Volbeda A, van Mechelen J, Meeuwenoord N, Overkleeft HS, van der Marel GA, Codée JDC. The Cyanopivaloyl Ester in the Automated Solid Phase Synthesis of Oligorhamnans. The Journal of Organic Chemistry. PMID 29148768 DOI: 10.1021/acs.joc.7b02511  1
2017 Schröder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codée JDC, van der Marel GA, ... Overkleeft HS, et al. Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines. Chemical Communications (Cambridge, England). PMID 29116266 DOI: 10.1039/c7cc07730k  1
2017 van Smeden J, Dijkhoff IM, Helder RWJ, Al-Khakany H, Boer DEC, Schreuder A, Kallemeijn WW, Absalah S, Overkleeft HS, Aerts JMFG, Bouwstra JA. In-situ visualization of glucocerebrosidase in human skin tissue: Zymography vs activity-based probe labeling. Journal of Lipid Research. PMID 29025868 DOI: 10.1194/jlr.M079376  1
2017 Gubbens J, Wu C, Zhu H, Filippov DV, Florea BI, Rigali S, Overkleeft HS, van Wezel GP. Intertwined precursor supply during biosynthesis of the catecholate-hydroxamate siderophores qinichelins in Streptomyces sp. MBT76. Acs Chemical Biology. PMID 28945067 DOI: 10.1021/acschembio.7b00597  1
2017 Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, ... ... Overkleeft HS, et al. A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Non-lysosomal Glucosylceramidase. Journal of the American Chemical Society. PMID 28937220 DOI: 10.1021/jacs.7b07352  1
2017 Zhang Q, Overkleeft HS, van der Marel GA, Codée JD. Synthetic zwitterionic polysaccharides. Current Opinion in Chemical Biology. 40: 95-101. PMID 28888143 DOI: 10.1016/j.cbpa.2017.07.010  1
2017 Liu Q, Kistemaker HAV, Overkleeft HS, van der Marel GA, Filippov DV. Synthesis of ribosyl-ribosyl-adenosine-5',5'',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose). Chemical Communications (Cambridge, England). PMID 28868552 DOI: 10.1039/c7cc05755e  1
2017 Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, ... ... Overkleeft HS, et al. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. The Journal of Clinical Investigation. PMID 28846070 DOI: 10.1172/JCI90895  1
2017 Zhang Q, Howell PL, Overkleeft HS, Filippov DV, van der Marel GA, Codée JDC. Chemical synthesis of guanosine diphosphate mannuronic acid (GDP-ManA) and its C-4-O-methyl and C-4-deoxy congeners. Carbohydrate Research. 450: 12-18. PMID 28822279 DOI: 10.1016/j.carres.2017.08.005  1
2017 Artola M, Wu L, Ferraz MJ, Kuo CL, Raich L, Breen IZ, Offen WA, Codée JDC, van der Marel GA, Rovira C, Aerts JMFG, Davies GJ, Overkleeft HS. 1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor. Acs Central Science. 3: 784-793. PMID 28776021 DOI: 10.1021/acscentsci.7b00214  1
2017 Narhe BD, Breman AC, Padwal J, Vandenput DAL, Scheidt JM, Benningshof JCJ, van der Marel GA, Overkleeft HS, van der Stelt M, Filippov DV. Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory. Bioorganic & Medicinal Chemistry. PMID 28720326 DOI: 10.1016/j.bmc.2017.07.016  1
2017 Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Overkleeft HS, Aerts JMFG. Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes". Acs Central Science. 3: 673. PMID 28691081 DOI: 10.1021/acscentsci.7b00185  1
2017 Kytidou K, Beenakker TJM, Westerhof LB, Hokke CH, Moolenaar GF, Goosen N, Mirzaian M, Ferraz MJ, de Geus M, Kallemeijn WW, Overkleeft HS, Boot RG, Schots A, Bosch D, Aerts JMFG. Human Alpha Galactosidases Transiently Produced in Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease. Frontiers in Plant Science. 8: 1026. PMID 28680430 DOI: 10.3389/fpls.2017.01026  1
2017 Besse A, Stolze SC, Rasche L, Weinhold N, Morgan GJ, Kraus M, Bader J, Overkleeft HS, Besse L, Driessen C. Carfilzomib resistance due to ABCB1/MDR1 overexpression is overcome by nelfinavir and lopinavir in multiple myeloma. Leukemia. PMID 28676669 DOI: 10.1038/leu.2017.212  1
2017 van Esbroeck ACM, Janssen APA, Cognetta AB, Ogasawara D, Shpak G, van der Kroeg M, Kantae V, Baggelaar MP, de Vrij FMS, Deng H, Allarà M, Fezza F, Lin Z, van der Wel T, Soethoudt M, ... ... Overkleeft HS, et al. Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science (New York, N.Y.). 356: 1084-1087. PMID 28596366 DOI: 10.1126/science.aaf7497  1
2017 Wu L, Jiang J, Jin Y, Kallemeijn WW, Kuo CL, Artola M, Dai W, van Elk C, van Eijk M, van der Marel GA, Codée JDC, Florea BI, Aerts JMFG, Overkleeft HS, Davies GJ. Activity-based probes for functional interrogation of retaining β-glucuronidases. Nature Chemical Biology. PMID 28581485 DOI: 10.1038/nchembio.2395  1
2017 van der Vorm S, Hansen T, Overkleeft HS, van der Marel GA, Codée JDC. The influence of acceptor nucleophilicity on the glycosylation reaction mechanism. Chemical Science. 8: 1867-1875. PMID 28553477 DOI: 10.1039/c6sc04638j  1
2017 Hagen B, van Dijk JHM, Zhang Q, Overkleeft HS, van der Marel GA, Codée JDC. Synthesis of the Staphylococcus aureus Strain M Capsular Polysaccharide Repeating Unit. Organic Letters. PMID 28485610 DOI: 10.1021/acs.orglett.7b00747  1
2017 VAN Elsland DM, Bos E, Pawlak JB, Overkleeft HS, Koster AJ, VAN Kasteren SI. Correlative light and electron microscopy reveals discrepancy between gold and fluorescence labelling. Journal of Microscopy. 267: 309-317. PMID 28470743 DOI: 10.1111/jmi.12567  1
2017 Beenakker TJM, Wander D, Offen WA, Artola M, Raich L, Ferraz MJ, Li KY, Houben JHPM, van Rijssel ER, Hansen T, van der Marel GA, Codée JDC, Aerts JMFG, Rovira C, Davies GJ, ... Overkleeft HS, et al. Carba-Cyclophellitols are Neutral Retaining Glucosidase Inhibitors. Journal of the American Chemical Society. PMID 28463498 DOI: 10.1021/jacs.7b01773  1
2017 van der Vorm S, Overkleeft HS, van der Marel GA, Codée JD. Stereoselectivity of conformationally restricted glucosazide donors. The Journal of Organic Chemistry. PMID 28401764 DOI: 10.1021/acs.joc.7b00470  1
2017 van Rijssel E, Janssen A, Males A, Davies G, van der Marel G, Overkleeft HS, Codée J. Conformational behaviour of mannuronic acid based azasugars. Chembiochem : a European Journal of Chemical Biology. PMID 28256791 DOI: 10.1002/cbic.201700080  1
2017 Kovács J, Poór P, Kaschani F, Chandrasekar B, Hong TN, Misas-Villamil JC, Xin BT, Kaiser M, Overkleeft HS, Tari I, van der Hoorn RA. Proteasome Activity Profiling Uncovers Alteration of Catalytic β2 and β5 Subunits of the Stress-Induced Proteasome during Salinity Stress in Tomato Roots. Frontiers in Plant Science. 8: 107. PMID 28217134 DOI: 10.3389/fpls.2017.00107  1
2017 Kallemeijn WW, Scheij S, Hoogendoorn S, Witte MD, Herrera Moro Chao D, van Roomen CP, Ottenhoff R, Overkleeft HS, Boot RG, Aerts JM. Investigations on therapeutic glucocerebrosidases through paired detection with fluorescent activity-based probes. Plos One. 12: e0170268. PMID 28207759 DOI: 10.1371/journal.pone.0170268  1
2017 Engelsma SB, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Filippov DV. Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates. Angewandte Chemie (International Ed. in English). PMID 28170152 DOI: 10.1002/anie.201611878  1
2017 Weyburne ES, Wilkins OM, Sha Z, Williams DA, Pletnev AA, de Bruin G, Overkleeft HS, Goldberg AL, Cole MD, Kisselev AF. Inhibition of the Proteasome β2 Site Sensitizes Triple-Negative Breast Cancer Cells to β5 Inhibitors and Suppresses Nrf1 Activation. Cell Chemical Biology. 24: 218-230. PMID 28132893 DOI: 10.1016/j.chembiol.2016.12.016  1
2017 Misas-Villamil JC, van der Burgh AM, Grosse-Holz F, Bach-Pages M, Kovács J, Kaschani F, Schilasky S, Emon AE, Ruben M, Kaiser M, Overkleeft HS, van der Hoorn RA. Subunit-selective proteasome activity profiling uncovers uncoupled proteasome subunit activities during bacterial infections. The Plant Journal : For Cell and Molecular Biology. PMID 28117509 DOI: 10.1111/tpj.13494  1
2017 Baggelaar MP, van Esbroeck A, van Rooden E, Florea BI, Overkleeft HS, Marsicano G, Chaouloff F, van der Stelt M. Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases. Acs Chemical Biology. PMID 28106377 DOI: 10.1021/acschembio.6b01052  1
2017 Mirzaian M, Wisse P, Ferraz MJ, Marques AR, Gaspar P, Oussoren SV, Kytidou K, Codée JD, van der Marel G, Overkleeft HS, Aerts JM. Simultaneous quantitation of sphingoid bases by UPLC-ESI-MS/MS with identical (13)C-encoded internal standards. Clinica Chimica Acta; International Journal of Clinical Chemistry. PMID 28089753 DOI: 10.1016/j.cca.2017.01.014  1
2017 Hagen B, Ali S, Overkleeft HS, van der Marel GA, Codée JD. Mapping the reactivity and selectivity of 2-azidofucosyl donors for the assembly of N-acetyl fucosamine containing bacterial oligosaccharides. The Journal of Organic Chemistry. PMID 28051314 DOI: 10.1021/acs.joc.6b02593  1
2017 Soriano GP, Overkleeft HS, Florea BI. Two-Step Activity-Based Protein Profiling with the Proteasome System as Model of Study. Methods in Molecular Biology (Clifton, N.J.). 1491: 205-215. PMID 27778291 DOI: 10.1007/978-1-4939-6439-0_15  1
2017 Prely L, Klein T, Geurink PP, Paal K, Overkleeft HS, Bischoff R. Activity-Dependent Photoaffinity Labeling of Metalloproteases. Methods in Molecular Biology (Clifton, N.J.). 1491: 103-111. PMID 27778284 DOI: 10.1007/978-1-4939-6439-0_8  1
2017 van Kasteren SI, Florea BI, Overkleeft HS. Activity-Based Protein Profiling: From Chemical Novelty to Biomedical Stalwart. Methods in Molecular Biology (Clifton, N.J.). 1491: 1-8. PMID 27778277 DOI: 10.1007/978-1-4939-6439-0_1  1
2016 van Elsland DM, Bos E, de Boer W, Overkleeft HS, Koster AJ, van Kasteren SI. Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes. Chemical Science. 7: 752-758. PMID 28791116 DOI: 10.1039/c5sc02905h  1
2016 Marques AR, Willems LI, Herrera Moro D, Florea BI, Scheij S, Ottenhoff R, van Roomen C, Verhoek M, Nelson JK, Kallemeijn WW, Biela-Banas A, Martin OR, Cachón-González MB, Kim NN, Cox TM, ... ... Overkleeft HS, et al. A specific activity-based probe to monitor family GH59 galactosylceramidase - the enzyme deficient in Krabbe disease. Chembiochem : a European Journal of Chemical Biology. PMID 28000364 DOI: 10.1002/cbic.201600561  1
2016 Deng H, Kooijman S, van den Nieuwendijk AM, Ogasawara D, van der Wel T, van Dalen F, Baggelaar MP, Janssen FJ, van den Berg RJ, den Dulk H, Cravatt BF, Overkleeft HS, Rensen PC, van der Stelt M. Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. Journal of Medicinal Chemistry. PMID 27992221 DOI: 10.1021/acs.jmedchem.6b01482  1
2016 van der Es D, Hogendorf WF, Overkleeft HS, van der Marel GA, Codée JD. Teichoic acids: synthesis and applications. Chemical Society Reviews. PMID 27990523 DOI: 10.1039/c6cs00270f  1
2016 Nabuurs RJ, Kapoerchan VV, Metaxas A, Hafith S, de Backer M, Welling MM, Jiskoot W, van den Nieuwendijk AM, Windhorst AD, Overkleeft HS, van Buchem MA, Overhand M, van der Weerd L. Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds. Bioorganic & Medicinal Chemistry. PMID 27838168 DOI: 10.1016/j.bmc.2016.05.022  1
2016 Huber EM, Heinemeyer W, de Bruin G, Overkleeft HS, Groll M. A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i. The Embo Journal. PMID 27789522 DOI: 10.15252/embj.201695222  1
2016 Jian J, Tian QY, Hettinghouse A, Zhao S, Liu H, Wei J, Grunig G, Zhang W, Setchell KD, Sun Y, Overkleeft HS, Chan GL, Liu CJ. Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease. Ebiomedicine. PMID 27789271 DOI: 10.1016/j.ebiom.2016.10.010  1
2016 Pawlak JB, Hos BJ, van de Graaff MJ, Megantari OA, Meeuwenoord N, Overkleeft HS, Filippov DV, Ossendorp F, van Kasteren SI. The Optimization Of Bioorthogonal Epitope Ligation Within MHC-I Complexes. Acs Chemical Biology. PMID 27704768 DOI: 10.1021/acschembio.6b00498  1
2016 Bhattarai S, Ghannam K, Krause S, Benveniste O, Marg A, de Bruin G, Xin BT, Overkleeft HS, Spuler S, Stenzel W, Feist E. The immunoproteasomes are key to regulate myokines and MHC class I expression in idiopathic inflammatory myopathies. Journal of Autoimmunity. PMID 27522114 DOI: 10.1016/j.jaut.2016.08.004  1
2016 Jian J, Zhao S, Tian QY, Liu H, Zhao Y, Chen WC, Grunig G, Torres PA, Wang BC, Zeng B, Pastores G, Tang W, Sun Y, Grabowski GA, Kong MX, ... ... Overkleeft HS, et al. Association Between Progranulin and Gaucher Disease. Ebiomedicine. PMID 27515686 DOI: 10.1016/j.ebiom.2016.08.004  1
2016 Kistemaker HA, Nardozza AP, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV. Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides. Angewandte Chemie (International Ed. in English). 55: 10634-8. PMID 27464500 DOI: 10.1002/anie.201604058  1
2016 Ben Bdira F, Jiang J, Kallemeijn WW, Haan A, Florea BI, Bleijlevens B, Boot RG, Overkleeft HS, Aerts JM, Ubbink M. HYDROPHOBIC INTERACTIONS CONTRIBUTE TO CONFORMATIONAL STABILIZATION OF ENDO-GLYCOSYLCERAMIDASE II BY MECHANISM-BASED PROBES. Biochemistry. PMID 27455091 DOI: 10.1021/acs.biochem.6b00363  1
2016 Xin BT, de Bruin G, Huber EM, Besse A, Florea BI, Filippov DV, van der Marel GA, Kisselev AF, van der Stelt M, Driessen C, Groll M, Overkleeft HS. Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes. Journal of Medicinal Chemistry. PMID 27438186 DOI: 10.1021/acs.jmedchem.6b00705  1
2016 de Bruin G, Xin BT, Florea BI, Overkleeft HS. Proteasome subunit selective activity-based probes report on proteasome core particle composition in a native-PAGE FRET assay. Journal of the American Chemical Society. PMID 27428761 DOI: 10.1021/jacs.6b04207  1
2016 Kallemeijn W, Scheij S, Voorn-Brouwer TM, Witte MD, Verhoek M, Overkleeft HS, Boot RG, Aerts JM. Endo-β-glucosidase tag allowing dual detection of fusion proteins by fluorescent mechanism-based probes and activity measurement. Chembiochem : a European Journal of Chemical Biology. PMID 27383447 DOI: 10.1002/cbic.201600312  1
2016 Gential GP, Ho NI, Chiodo F, Meeuwenoord N, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV. Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates. Bioorganic & Medicinal Chemistry Letters. PMID 27289322 DOI: 10.1016/j.bmcl.2016.05.094  1
2016 Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JD, Boot RG, Davies GJ, Overkleeft HS, Aerts JM. Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes. Acs Central Science. 2: 351-8. PMID 27280170 DOI: 10.1021/acscentsci.6b00057  1
2016 Mirzaian M, Wisse P, Ferraz MJ, Marques AR, Gabriel TL, van Roomen CP, Ottenhoff R, van Eijk M, Codée JD, van der Marel GA, Overkleeft HS, Aerts JM. Accurate quantification of sphingosine-1-phosphate in normal and Fabry disease plasma, cells and tissues by LC-MS/MS with (13)C-encoded natural S1P as internal standard. Clinica Chimica Acta; International Journal of Clinical Chemistry. 459: 36-44. PMID 27221202 DOI: 10.1016/j.cca.2016.05.017  1
2016 Spur EM, Althof N, Respondek D, Klingel K, Heuser A, Overkleeft HS, Voigt A. Inhibition of chymotryptic-like standard proteasome activity exacerbates doxorubicin-induced cytotoxicity in primary cardiomyocytes. Toxicology. 353: 34-47. PMID 27155237 DOI: 10.1016/j.tox.2016.04.010  1
2016 Stolze SC, Liu N, Wijdeven RH, Tuin AW, van den Nieuwendijk AM, Florea BI, van der Stelt M, van der Marel GA, Neefjes JJ, Overkleeft HS. Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes. Molecular Biosystems. PMID 27138522 DOI: 10.1039/c6mb00257a  1
2016 Soriano GP, Besse L, Li N, Kraus M, Besse A, Meeuwenoord N, Bader J, Everts B, den Dulk H, Overkleeft HS, Florea BI, Driessen C. Proteasome inhibitor-adapted myeloma cells are largely independent from proteasome activity and show complex proteomic changes in particular in redox and energy metabolism. Leukemia. PMID 27118406 DOI: 10.1038/leu.2016.102  1
2016 Xin BT, Schimmack G, Du Y, Florea BI, van der Marel GA, Driessen C, Krappmann D, Overkleeft HS. Development of new Malt1 inhibitors and probes. Bioorganic & Medicinal Chemistry. PMID 27085674 DOI: 10.1016/j.bmc.2016.03.035  1
2016 Smid BE, Ferraz MJ, Verhoek M, Mirzaian M, Wisse P, Overkleeft HS, Hollak CE, Aerts JM. Biochemical response to substrate reduction therapy versus enzyme replacement therapy in Gaucher disease type 1 patients. Orphanet Journal of Rare Diseases. 11: 28. PMID 27008851 DOI: 10.1186/s13023-016-0413-3  1
2016 van der Es D, Groenia NA, Laverde D, Overkleeft HS, Huebner J, van der Marel GA, Codée JD. Synthesis of E. faecium wall teichoic acid fragments. Bioorganic & Medicinal Chemistry. PMID 26993744 DOI: 10.1016/j.bmc.2016.03.019  1
2016 Chen S, Kammerl IE, Vosyka O, Baumann T, Yu Y, Wu Y, Irmler M, Overkleeft HS, Beckers J, Eickelberg O, Meiners S, Stoeger T. Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages. Cell Death and Differentiation. PMID 26990663 DOI: 10.1038/cdd.2016.3  1
2016 Banno A, Garcia DA, van Baarsel ED, Metz PJ, Fisch K, Widjaja CE, Kim SH, Lopez J, Chang AN, Geurink PP, Florea BI, Overkleeft HS, Ovaa H, Bui JD, Yang J, et al. Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget. PMID 26930717 DOI: 10.18632/oncotarget.7596  1
2016 de Bruin G, Mock ED, Hoogendoorn S, van den Nieuwendijk AM, Mazurek J, van der Marel GA, Florea BI, Overkleeft HS. Enantioselective synthesis of adamantylalanine and carboranylalanine and their incorporation into the proteasome inhibitor bortezomib. Chemical Communications (Cambridge, England). PMID 26894389 DOI: 10.1039/c6cc01156j  1
2016 Kwan DH, Jin Y, Jiang J, Chen HM, Kötzler MP, Overkleeft HS, Davies G, Withers SG. Chemoenzymatic synthesis of 6-phospho-cyclophellitol as a novel probe of 6-phospho-β-glucosidases. Febs Letters. PMID 26790390 DOI: 10.1002/1873-3468.12059  1
2016 Kammerl IE, Dann A, Mossina A, Brech D, Lukas C, Vosyka O, Nathan P, Conlon TM, Wagner DE, Overkleeft HS, Prasse A, Rosas IO, Straub T, Krauss-Etschmann S, Königshoff M, et al. Impairment of Immunoproteasome Function by Cigarette Smoke and in COPD. American Journal of Respiratory and Critical Care Medicine. PMID 26756824 DOI: 10.1164/rccm.201506-1122OC  1
2016 Ferraz MJ, Marques ARA, Gaspar P, Mirzaian M, van Roomen C, Ottenhoff R, Alfonso P, Irún P, Giraldo P, Wisse P, Sá Miranda C, Overkleeft HS, Aerts JM. Lyso-glycosphingolipid abnormalities in different murine models of lysosomal storage disorders Molecular Genetics and Metabolism. 117: 186-193. DOI: 10.1016/j.ymgme.2015.12.006  1
2016 Xin BT, de Bruin G, Plomp JW, Florea BI, van der Marel GA, Overkleeft HS. Incorporation of the Constrained Peptidomimetic, 5-Methylpyridin-2-one into Peptide Vinyl Sulfones and Peptide Epoxy Ketones is Detrimental for Proteasome Inhibition European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201501401  1
2015 Jiang J, Kallemeijn WW, Wright DW, van den Nieuwendijk AMCH, Rohde VC, Folch EC, van den Elst H, Florea BI, Scheij S, Donker-Koopman WE, Verhoek M, Li N, Schürmann M, Mink D, Boot RG, ... ... Overkleeft HS, et al. In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-l-fucosidases. Chemical Science. 6: 2782-false. PMID 29142681 DOI: 10.1039/c4sc03739a  1
2015 Ogasawara D, Deng H, Viader A, Baggelaar MP, Breman A, den Dulk H, van den Nieuwendijk AM, Soethoudt M, van der Wel T, Zhou J, Overkleeft HS, Sanchez-Alavez M, Mo S, Nguyen W, Conti B, et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proceedings of the National Academy of Sciences of the United States of America. PMID 26668358 DOI: 10.1073/pnas.1522364112  1
2015 Driessen C, Kraus M, Joerger M, Rosing H, Bader J, Hitz F, Berset C, Xyrafas A, Hawle H, Berthod G, Overkleeft HS, Sessa C, Huitema A, Pabst T, von Moos R, et al. Treatment with the HIV protease inhibitor Nelfinavir triggers the unfolded protein response and may overcome proteasome inhibitor resistance of multiple myeloma in combination with bortezomib: a phase I trial (SAKK 65/08). Haematologica. PMID 26659919 DOI: 10.3324/haematol.2015.135780  1
2015 Hsu MT, Guo CL, Liou AY, Chang TY, Ng MC, Florea BI, Overkleeft HS, Wu YL, Liao JC, Cheng PL. Stage-Dependent Axon Transport of Proteasomes Contributes to Axon Development. Developmental Cell. 35: 418-431. PMID 26609957 DOI: 10.1016/j.devcel.2015.10.018  1
2015 Janssen FJ, Baggelaar MP, Hummel JJ, Overkleeft HS, Cravatt BF, Boger DL, van der Stelt M. Comprehensive Analysis of Structure Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors. Journal of Medicinal Chemistry. PMID 26584396 DOI: 10.1021/acs.jmedchem.5b01627  1
2015 Paeschke A, Possehl A, Klingel K, Voss M, Voss K, Kesphol M, Sauter M, Overkleeft HS, Althof N, Garlanda C, Voigt A. The immunoproteasome controls the availability of the cardio-protective pattern recognition molecule Pentraxin3. European Journal of Immunology. PMID 26578407 DOI: 10.1002/eji.201545892  1
2015 de Bruin G, Xin BT, Kraus M, van der Stelt M, van der Marel GA, Kisselev AF, Driessen C, Florea BI, Overkleeft HS. A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities. Angewandte Chemie (International Ed. in English). PMID 26511210 DOI: 10.1002/anie.201509092  1
2015 van den Berg RJ, van Rijssel ER, Ferraz MJ, Houben J, Strijland A, Donker-Koopman WE, Wennekes T, Bonger KM, Ghisaidoobe AB, Hoogendoorn S, van der Marel GA, Codée JD, Overkleeft HS, Aerts JM. Synthesis and Evaluation of Hybrid Structures Composed of Two Glucosylceramide Synthase Inhibitors. Chemmedchem. PMID 26492941 DOI: 10.1002/cmdc.201500407  1
2015 Herrera Moro Chao D, Kallemeijn WW, Marques AR, Orre M, Ottenhoff R, van Roomen C, Foppen E, Renner MC, Moeton M, van Eijk M, Boot RG, Kamphuis W, Hol EM, Aten J, Overkleeft HS, et al. Visualization of Active Glucocerebrosidase in Rodent Brain with High Spatial Resolution following In Situ Labeling with Fluorescent Activity Based Probes. Plos One. 10: e0138107. PMID 26418157 DOI: 10.1371/journal.pone.0138107  1
2015 Kistemaker HA, Overkleeft HS, van der Marel GA, Filippov DV. Branching of poly(ADP-ribose): Synthesis of the Core Motif. Organic Letters. 17: 4328-31. PMID 26307949 DOI: 10.1021/acs.orglett.5b02143  1
2015 Lehmann KC, Gulyaeva A, Zevenhoven-Dobbe JC, Janssen GM, Ruben M, Overkleeft HS, van Veelen PA, Samborskiy DV, Kravchenko AA, Leontovich AM, Sidorov IA, Snijder EJ, Posthuma CC, Gorbalenya AE. Discovery of an essential nucleotidylating activity associated with a newly delineated conserved domain in the RNA polymerase-containing protein of all nidoviruses. Nucleic Acids Research. PMID 26304538 DOI: 10.1093/nar/gkv838  1
2015 Marques AR, Aten J, Ottenhoff R, van Roomen CP, Herrera Moro D, Claessen N, Vinueza Veloz MF, Zhou K, Lin Z, Mirzaian M, Boot RG, De Zeeuw CI, Overkleeft HS, Yildiz Y, Aerts JM. Reducing GBA2 Activity Ameliorates Neuropathology in Niemann-Pick Type C Mice. Plos One. 10: e0135889. PMID 26275242 DOI: 10.1371/journal.pone.0135889  1
2015 Volbeda AG, Kistemaker HA, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD. Chemoselective Cleavage of p-Methoxybenzyl and 2-Naphthylmethyl Ethers Using a Catalytic Amount of HCl in Hexafluoro-2-propanol. The Journal of Organic Chemistry. 80: 8796-806. PMID 26230920 DOI: 10.1021/acs.joc.5b01030  1
2015 Latorre A, Rodríguez S, González FV, Florea BI, Overkleeft HS. Synthetic Studies on the Preparation of Alanyl Epoxysulfones as Cathepsin Cysteine Protease Electrophilic Traps. The Journal of Organic Chemistry. 80: 7752-6. PMID 26147718 DOI: 10.1021/acs.joc.5b01013  1
2015 Kraus J, Kraus M, Liu N, Besse L, Bader J, Geurink PP, de Bruin G, Kisselev AF, Overkleeft H, Driessen C. The novel β2-selective proteasome inhibitor LU-102 decreases phosphorylation of I kappa B and induces highly synergistic cytotoxicity in combination with ibrutinib in multiple myeloma cells. Cancer Chemotherapy and Pharmacology. PMID 26099967 DOI: 10.1007/s00280-015-2801-0  1
2015 Baggelaar MP, Chameau PJ, Kantae V, Hummel J, Hsu KL, Janssen F, van der Wel T, Soethoudt M, Deng H, den Dulk H, Allarà M, Florea BI, Di Marzo V, Wadman WJ, Kruse CG, ... Overkleeft HS, et al. Highly Selective, Reversible Inhibitor Identified by Comparative Chemoproteomics Modulates Diacylglycerol Lipase Activity in Neurons. Journal of the American Chemical Society. 137: 8851-7. PMID 26083464 DOI: 10.1021/jacs.5b04883  1
2015 Jiang J, Beenakker TJ, Kallemeijn WW, van der Marel GA, van den Elst H, Codée JD, Aerts JM, Overkleeft HS. Comparing Cyclophellitol N-Alkyl and N-Acyl Cyclophellitol Aziridines as Activity-Based Glycosidase Probes. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 10861-9. PMID 26073749 DOI: 10.1002/chem.201501313  1
2015 Kraus M, Bader J, Geurink PP, Weyburne ES, Mirabella AC, Silzle T, Shabaneh TB, van der Linden WA, de Bruin G, Haile SR, van Rooden E, Appenzeller C, Li N, Kisselev AF, Overkleeft H, et al. The novel β2-selective proteasome inhibitor LU-102 synergizes with bortezomib and carfilzomib to overcome proteasome inhibitor resistance of myeloma cells. Haematologica. PMID 26069288 DOI: 10.3324/haematol.2014.109421  1
2015 Wisse P, de Geus MA, Cross G, van den Nieuwendijk AM, van Rooden EJ, van den Berg RJ, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS. Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy. The Journal of Organic Chemistry. 80: 7258-65. PMID 26061009 DOI: 10.1021/acs.joc.5b00823  1
2015 Willems MM, Zom GG, Meeuwenoord N, Khan S, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD. Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents. Chemmedchem. PMID 26059481 DOI: 10.1002/cmdc.201500196  1
2015 Wiemhoefer A, Stargardt A, van der Linden WA, Renner MC, van Kesteren RE, Stap J, Raspe MA, Tomkinson B, Kessels HW, Ovaa H, Overkleeft HS, Florea B, Reits EA. Tripeptidyl Peptidase II Mediates Levels of Nuclear Phosphorylated ERK1 and ERK2. Molecular & Cellular Proteomics : McP. 14: 2177-93. PMID 26041847 DOI: 10.1074/mcp.M114.043331  1
2015 Huber EM, de Bruin G, Heinemeyer W, Paniagua Soriano G, Overkleeft HS, Groll M. Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors. Journal of the American Chemical Society. 137: 7835-42. PMID 26020686 DOI: 10.1021/jacs.5b03688  1
2015 Keller IE, Vosyka O, Takenaka S, Kloß A, Dahlmann B, Willems LI, Verdoes M, Overkleeft HS, Marcos E, Adnot S, Hauck SM, Ruppert C, Günther A, Herold S, Ohno S, et al. Regulation of immunoproteasome function in the lung. Scientific Reports. 5: 10230. PMID 25989070 DOI: 10.1038/srep10230  1
2015 Zhang Q, van Rijssel ER, Walvoort MT, Overkleeft HS, van der Marel GA, Codée JD. Acceptor reactivity in the total synthesis of alginate fragments containing α-L-guluronic acid and β-D-mannuronic acid. Angewandte Chemie (International Ed. in English). 54: 7670-3. PMID 25960101 DOI: 10.1002/anie.201502581  1
2015 Liu N, Hoogendoorn S, van de Kar B, Kaptein A, Barf T, Driessen C, Filippov DV, van der Marel GA, van der Stelt M, Overkleeft HS. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Organic & Biomolecular Chemistry. 13: 5147-57. PMID 25849561 DOI: 10.1039/c5ob00474h  1
2015 Downey SL, Florea BI, Overkleeft HS, Kisselev AF. Use of proteasome inhibitors. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. 109: 9.10.1-9. PMID 25845565 DOI: 10.1002/0471142735.im0910s109  1
2015 Mirzaian M, Wisse P, Ferraz MJ, Gold H, Donker-Koopman WE, Verhoek M, Overkleeft HS, Boot RG, Kramer G, Dekker N, Aerts JM. Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard. Blood Cells, Molecules & Diseases. 54: 307-14. PMID 25842368 DOI: 10.1016/j.bcmd.2015.01.006  1
2015 van Rijssel ER, van Delft P, van Marle DV, Bijvoets SM, Lodder G, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD. Stereoselectivity in the Lewis acid mediated reduction of ketofuranoses. The Journal of Organic Chemistry. 80: 4553-65. PMID 25826382 DOI: 10.1021/acs.joc.5b00419  1
2015 Matusiak N, van Waarde A, Rozeveld D, van Oosterhout AJ, Heijink IH, Castelli R, Overkleeft HS, Bischoff R, Dierckx RA, Elsinga PH. MicroPET Evaluation of a Hydroxamate-Based MMP Inhibitor, [(18)F]FB-ML5, in a Mouse Model of Cigarette Smoke-Induced Acute Airway Inflammation. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 17: 680-7. PMID 25822732 DOI: 10.1007/s11307-015-0847-3  1
2015 Pawlak JB, Gential GP, Ruckwardt TJ, Bremmers JS, Meeuwenoord NJ, Ossendorp FA, Overkleeft HS, Filippov DV, van Kasteren SI. Bioorthogonal deprotection on the dendritic cell surface for chemical control of antigen cross-presentation. Angewandte Chemie (International Ed. in English). 54: 5628-31. PMID 25784151 DOI: 10.1002/anie.201500301  1
2015 Ouchaou K, Maire F, Salo O, Ali H, Hankemeier T, van der Marel GA, Filippov DV, Bovenberg RA, Vreeken RJ, Driessen AJ, Overkleeft HS. A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues. Chembiochem : a European Journal of Chemical Biology. 16: 915-23. PMID 25766600 DOI: 10.1002/cbic.201402686  1
2015 Ouairy CM, Ferraz MJ, Boot RG, Baggelaar MP, van der Stelt M, Appelman M, van der Marel GA, Florea BI, Aerts JM, Overkleeft HS. Development of an acid ceramidase activity-based probe. Chemical Communications (Cambridge, England). 51: 6161-3. PMID 25748248 DOI: 10.1039/c5cc00356c  1
2015 Kistemaker HA, Lameijer LN, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Filippov DV. Synthesis of well-defined adenosine diphosphate ribose oligomers. Angewandte Chemie (International Ed. in English). 54: 4915-8. PMID 25704172 DOI: 10.1002/anie.201412283  1
2015 Padwal JD, Filippov DV, Narhe BD, Aertssen S, Beuving RJ, Benningshof JC, van der Marel GA, Overkleeft HS, van der Stelt M. Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery. Bioorganic & Medicinal Chemistry. 23: 2650-5. PMID 25691210 DOI: 10.1016/j.bmc.2015.01.040  1
2015 van der Wel T, Janssen FJ, Baggelaar MP, Deng H, den Dulk H, Overkleeft HS, van der Stelt M. A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α. Journal of Lipid Research. 56: 927-35. PMID 25684760 DOI: 10.1194/jlr.D056390  1
2015 Rahimian S, Kleinovink JW, Fransen MF, Mezzanotte L, Gold H, Wisse P, Overkleeft H, Amidi M, Jiskoot W, Löwik CW, Ossendorp F, Hennink WE. Near-infrared labeled, ovalbumin loaded polymeric nanoparticles based on a hydrophilic polyester as model vaccine: Invivo tracking and evaluation of antigen-specific CD8+ T cell immune response Biomaterials. 37: 469-477. PMID 25453974 DOI: 10.1016/j.biomaterials.2014.10.043  1
2015 Matusiak N, Castelli R, Tuin AW, Overkleeft HS, Wisastra R, Dekker FJ, Prély LM, Bischoff R, Bischoff RP, van Waarde A, Dierckx RA, Elsinga PH. A dual inhibitor of matrix metalloproteinases and a disintegrin and metalloproteinases, [¹⁸F]FB-ML5, as a molecular probe for non-invasive MMP/ADAM-targeted imaging. Bioorganic & Medicinal Chemistry. 23: 192-202. PMID 25438884 DOI: 10.1016/j.bmc.2014.11.013  1
2015 Van Elsland DM, Bos E, De Boer W, Overkleeft HS, Koster AJ, Van Kasteren SI. Detection of bioorthogonal groups by correlative light and electron microscopy allows imaging of degraded bacteria in phagocytes Chemical Science. 7: 752-758. DOI: 10.1039/c5sc02905h  1
2015 Jiang J, Kallemeijn WW, Wright DW, Van Den Nieuwendijk AMCH, Rohde VC, Folch EC, Van Den Elst H, Florea BI, Scheij S, Donker-Koopman WE, Verhoek M, Li N, Schürmann M, Mink D, Boot RG, ... ... Overkleeft HS, et al. In vitro and in vivo comparative and competitive activity-based protein profiling of GH29 α-L-fucosidases Chemical Science. 6: 2782-2789. DOI: 10.1039/c4sc03739a  1
2015 van Elsland DM, Bos E, Overkleeft HS, Koster AJ, van Kasteren SI. The potential of bioorthogonal chemistry for correlative light and electron microscopy: a call to arms Journal of Chemical Biology. DOI: 10.1007/s12154-015-0134-4  1
2015 Kistemaker HAV, Meeuwenoord NJ, Overkleeft HS, Van Der Marel GA, Filippov DV. On the Synthesis of Oligonucleotides Interconnected through Pyrophosphate Linkages European Journal of Organic Chemistry. 2015: 6084-6091. DOI: 10.1002/ejoc.201500911  1
2015 Hoogendoorn S, Mock ED, Strijland A, Donker-Koopman WE, van den Elst H, van den Berg RJBHN, Aerts JMFG, van der Marel GA, Overkleeft HS. ortho-Carborane-Modified N-Substituted Deoxynojirimycins European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201500364  1
2015 Wisse P, Gold H, Mirzaian M, Ferraz MJ, Lutteke G, Van Den Berg RJBHN, Van Den Elst H, Lugtenburg J, Van Der Marel GA, Aerts JMFG, Codée JDC, Overkleeft HS. Synthesis of a panel of carbon-13-labelled (glyco)sphingolipids European Journal of Organic Chemistry. 2015: 2661-2677. DOI: 10.1002/ejoc.201500025  1
2015 Wong CS, Hoogendoorn S, Van Der Marel GA, Overkleeft HS, Codée JDC. Targeted delivery of fluorescent high-mannose-type oligosaccharide cathepsin inhibitor conjugates Chempluschem. 80: 928-937. DOI: 10.1002/cplu.201500004  1
2014 Zom GG, Filippov DV, van der Marel GA, Overkleeft HS, Melief CJ, Ossendorp F. Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule. Oncoimmunology. 3: e947892. PMID 25610736 DOI: 10.4161/21624011.2014.947892  1
2014 Kallemeijn WW, Witte MD, Voorn-Brouwer TM, Walvoort MT, Li KY, Codée JD, van der Marel GA, Boot RG, Overkleeft HS, Aerts JM. A sensitive gel-based method combining distinct cyclophellitol-based probes for the identification of acid/base residues in human retaining β-glucosidases. The Journal of Biological Chemistry. 289: 35351-62. PMID 25344605 DOI: 10.1074/jbc.M114.593376  1
2014 Ghisaidoobe AT, van den Berg RJ, Butt SS, Strijland A, Donker-Koopman WE, Scheij S, van den Nieuwendijk AM, Koomen GJ, van Loevezijn A, Leemhuis M, Wennekes T, van der Stelt M, van der Marel GA, van Boeckel CA, Aerts JM, ... Overkleeft HS, et al. Identification and development of biphenyl substituted iminosugars as improved dual glucosylceramide synthase/neutral glucosylceramidase inhibitors. Journal of Medicinal Chemistry. 57: 9096-104. PMID 25250725 DOI: 10.1021/jm501181z  1
2014 van Kasteren SI, Overkleeft HS. Endo-lysosomal proteases in antigen presentation. Current Opinion in Chemical Biology. 23: 8-15. PMID 25213682 DOI: 10.1016/j.cbpa.2014.08.011  1
2014 Hoogendoorn S, van Puijvelde GH, Kuiper J, van der Marel GA, Overkleeft HS. A multivalent ligand for the mannose-6-phosphate receptor for endolysosomal targeting of an activity-based probe. Angewandte Chemie (International Ed. in English). 53: 10975-8. PMID 25163608 DOI: 10.1002/anie.201406842  1
2014 Li KY, Jiang J, Witte MD, Kallemeijn WW, Donker-Koopman WE, Boot RG, Aerts JM, Codée JD, van der Marel GA, Overkleeft HS. Exploring functional cyclophellitol analogues as human retaining beta-glucosidase inhibitors. Organic & Biomolecular Chemistry. 12: 7786-91. PMID 25156485 DOI: 10.1039/c4ob01611d  1
2014 Hansen MJ, Velema WA, de Bruin G, Overkleeft HS, Szymanski W, Feringa BL. Proteasome inhibitors with photocontrolled activity. Chembiochem : a European Journal of Chemical Biology. 15: 2053-7. PMID 25125335 DOI: 10.1002/cbic.201402237  1
2014 Willems LI, Beenakker TJ, Murray B, Scheij S, Kallemeijn WW, Boot RG, Verhoek M, Donker-Koopman WE, Ferraz MJ, van Rijssel ER, Florea BI, Codée JD, van der Marel GA, Aerts JM, Overkleeft HS. Potent and selective activity-based probes for GH27 human retaining α-galactosidases. Journal of the American Chemical Society. 136: 11622-5. PMID 25105979 DOI: 10.1021/ja507040n  1
2014 Duivenvoorden BA, Ghauharali K, Scheij S, Boot RG, Aerts JM, van der Marel GA, Overkleeft HS, Codée JD. Design and synthesis of 4'-O-alkyl-chitobiosyl-4-methylumbelliferone as human chitinase fluorogenic substrates. Carbohydrate Research. 399: 26-37. PMID 25104395 DOI: 10.1016/j.carres.2014.07.007  1
2014 Willems LI, Jiang J, Li KY, Witte MD, Kallemeijn WW, Beenakker TJ, Schröder SP, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS. From covalent glycosidase inhibitors to activity-based glycosidase probes. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 10864-72. PMID 25100671 DOI: 10.1002/chem.201404014  1
2014 van Rijssel ER, van Delft P, Lodder G, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD. Furanosyl oxocarbenium ion stability and stereoselectivity. Angewandte Chemie (International Ed. in English). 53: 10381-5. PMID 25081839 DOI: 10.1002/anie.201405477  1
2014 Müller S, Garcia-Gonzalez E, Mainz A, Hertlein G, Heid NC, Mösker E, van den Elst H, Overkleeft HS, Genersch E, Süssmuth RD. Paenilamicin: structure and biosynthesis of a hybrid nonribosomal peptide/polyketide antibiotic from the bee pathogen Paenibacillus larvae. Angewandte Chemie (International Ed. in English). 53: 10821-5. PMID 25080172 DOI: 10.1002/anie.201404572  1
2014 Chandrasekar B, Colby T, Emran Khan Emon A, Jiang J, Hong TN, Villamor JG, Harzen A, Overkleeft HS, van der Hoorn RA. Broad-range glycosidase activity profiling. Molecular & Cellular Proteomics : McP. 13: 2787-800. PMID 25056938 DOI: 10.1074/mcp.O114.041616  1
2014 Willems MM, Zom GG, Khan S, Meeuwenoord N, Melief CJ, van der Stelt M, Overkleeft HS, Codée JD, van der Marel GA, Ossendorp F, Filippov DV. N-tetradecylcarbamyl lipopeptides as novel agonists for Toll-like receptor 2. Journal of Medicinal Chemistry. 57: 6873-8. PMID 25019313 DOI: 10.1021/jm500722p  1
2014 de Bruin G, Huber EM, Xin BT, van Rooden EJ, Al-Ayed K, Kim KB, Kisselev AF, Driessen C, van der Stelt M, van der Marel GA, Groll M, Overkleeft HS. Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes. Journal of Medicinal Chemistry. 57: 6197-209. PMID 25006746 DOI: 10.1021/jm500716s  1
2014 Willems MM, Zom GG, Meeuwenoord N, Ossendorp FA, Overkleeft HS, van der Marel GA, Codée JD, Filippov DV. Design, automated synthesis and immunological evaluation of NOD2-ligand-antigen conjugates. Beilstein Journal of Organic Chemistry. 10: 1445-53. PMID 24991299 DOI: 10.3762/bjoc.10.148  1
2014 Janssen FJ, Deng H, Baggelaar MP, Allarà M, van der Wel T, den Dulk H, Ligresti A, van Esbroeck AC, McGuire R, Di Marzo V, Overkleeft HS, van der Stelt M. Discovery of glycine sulfonamides as dual inhibitors of sn-1-diacylglycerol lipase α and α/β-hydrolase domain 6. Journal of Medicinal Chemistry. 57: 6610-22. PMID 24988361 DOI: 10.1021/jm500681z  1
2014 Xin BT, de Bruin G, Verdoes M, Filippov DV, van der Marel GA, Overkleeft HS. Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides. Organic & Biomolecular Chemistry. 12: 5710-8. PMID 24968066 DOI: 10.1039/c4ob00893f  1
2014 Castelli R, Schindler S, Walter SM, Kniep F, Overkleeft HS, Van der Marel GA, Huber SM, Codée JD. Activation of glycosyl halides by halogen bonding. Chemistry, An Asian Journal. 9: 2095-8. PMID 24962953 DOI: 10.1002/asia.201402259  1
2014 Zom GG, Khan S, Britten CM, Sommandas V, Camps MG, Loof NM, Budden CF, Meeuwenoord NJ, Filippov DV, van der Marel GA, Overkleeft HS, Melief CJ, Ossendorp F. Efficient induction of antitumor immunity by synthetic toll-like receptor ligand-peptide conjugates. Cancer Immunology Research. 2: 756-64. PMID 24950688 DOI: 10.1158/2326-6066.CIR-13-0223  1
2014 Willems LI, Overkleeft HS, van Kasteren SI. Current developments in activity-based protein profiling. Bioconjugate Chemistry. 25: 1181-91. PMID 24946272 DOI: 10.1021/bc500208y  1
2014 Li H, van der Linden WA, Verdoes M, Florea BI, McAllister FE, Govindaswamy K, Elias JE, Bhanot P, Overkleeft HS, Bogyo M. Assessing subunit dependency of the Plasmodium proteasome using small molecule inhibitors and active site probes. Acs Chemical Biology. 9: 1869-76. PMID 24918547 DOI: 10.1021/cb5001263  1
2014 Gubbens J, Zhu H, Girard G, Song L, Florea BI, Aston P, Ichinose K, Filippov DV, Choi YH, Overkleeft HS, Challis GL, van Wezel GP. Natural product proteomining, a quantitative proteomics platform, allows rapid discovery of biosynthetic gene clusters for different classes of natural products. Chemistry & Biology. 21: 707-18. PMID 24816229 DOI: 10.1016/j.chembiol.2014.03.011  1
2014 Engelsma SB, Willems LI, van Paaschen CE, van Kasteren SI, van der Marel GA, Overkleeft HS, Filippov DV. Acylazetine as a dienophile in bioorthogonal inverse electron-demand Diels-Alder ligation. Organic Letters. 16: 2744-7. PMID 24796604 DOI: 10.1021/ol501049c  1
2014 Nabuurs RJ, Kapoerchan VV, Metaxas A, de Jongh S, de Backer M, Welling MM, Jiskoot W, Windhorst AD, Overkleeft HS, van Buchem MA, Overhand M, van der Weerd L. Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands. Bioorganic & Medicinal Chemistry. 22: 2469-81. PMID 24657049 DOI: 10.1016/j.bmc.2014.02.054  1
2014 van Kasteren SI, Overkleeft H, Ovaa H, Neefjes J. Chemical biology of antigen presentation by MHC molecules Current Opinion in Immunology. 26: 21-31. PMID 24556397 DOI: 10.1016/j.coi.2013.10.005  1
2014 Wilkins OM, Downey SL, Weyburne ES, Williams DA, Mirabella AC, Overkleeft HS, Kisselev AF. Cell-line-specific high background in the Proteasome-Glo assay of proteasome trypsin-like activity. Analytical Biochemistry. 451: 1-3. PMID 24486333 DOI: 10.1016/j.ab.2014.01.009  1
2014 Paniagua Soriano G, De Bruin G, Overkleeft HS, Florea BI. Toward understanding induction of oxidative stress and apoptosis by proteasome inhibitors. Antioxidants & Redox Signaling. 21: 2419-43. PMID 24437477 DOI: 10.1089/ars.2013.5794  1
2014 Kraus M, Müller-Ide H, Rückrich T, Bader J, Overkleeft H, Driessen C. Ritonavir, nelfinavir, saquinavir and lopinavir induce proteotoxic stress in acute myeloid leukemia cells and sensitize them for proteasome inhibitor treatment at low micromolar drug concentrations Leukemia Research. 38: 383-392. PMID 24418752 DOI: 10.1016/j.leukres.2013.12.017  1
2014 Schipper-Krom S, Juenemann K, Jansen AH, Wiemhoefer A, van den Nieuwendijk R, Smith DL, Hink MA, Bates GP, Overkleeft H, Ovaa H, Reits E. Dynamic recruitment of active proteasomes into polyglutamine initiated inclusion bodies. Febs Letters. 588: 151-9. PMID 24291262 DOI: 10.1016/j.febslet.2013.11.023  1
2014 Ferraz MJ, Kallemeijn WW, Mirzaian M, Herrera Moro D, Marques A, Wisse P, Boot RG, Willems LI, Overkleeft HS, Aerts JM. Gaucher disease and Fabry disease: new markers and insights in pathophysiology for two distinct glycosphingolipidoses. Biochimica Et Biophysica Acta. 1841: 811-25. PMID 24239767 DOI: 10.1016/j.bbalip.2013.11.004  1
2014 Gaspar P, Kallemeijn WW, Strijland A, Scheij S, Van Eijk M, Aten J, Overkleeft HS, Balreira A, Zunke F, Schwake M, Sá Miranda C, Aerts JM. Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis. Journal of Lipid Research. 55: 138-45. PMID 24212238 DOI: 10.1194/jlr.M043802  1
2014 Van Delft P, De Witte W, Meeuwenoord NJ, Van Der Heden Van Noort GJ, Versluis F, Olsthoorn RCL, Overkleeft HS, Van Der Marel GA, Filippov DV. Design of a ribosyltriazole-annulated cyclooctyne for oligonucleotide labeling by strain-promoted alkyne-azide cycloaddition European Journal of Organic Chemistry. 2014: 7566-7571. DOI: 10.1002/ejoc.201403086  1
2014 Willems LI, Beenakker TJM, Murray B, Gagestein B, van den Elst H, van Rijssel ER, Codée JDC, Kallemeijn WW, Aerts JMFG, van der Marel GA, Overkleeft HS. Synthesis of α- and β-galactopyranose-configured isomers of cyclophellitol and cyclophellitol aziridine European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201402589  1
2014 Li KY, Jiang J, Witte MD, Kallemeijn WW, van den Elst H, Wong CS, Chander SD, Hoogendoorn S, Beenakker TJM, Codée JDC, Aerts JMFG, van der Marel GA, Overkleeft HS. Synthesis of cyclophellitol, cyclophellitol aziridine, and their tagged derivatives European Journal of Organic Chemistry. DOI: 10.1002/ejoc.201402588  1
2014 Li KY, Kallemeijn W, Jiang J, Walvoort M, Willems L, Beenakker T, Van Den Elst H, Van Der Marel G, Codée J, Aerts H, Florea B, Boot R, Witte M, Overkleeft H. Rational Design of Activity-Based Retaining β-Exoglucosidase Probes Concepts and Case Studies in Chemical Biology. 191-206. DOI: 10.1002/9783527687503.ch13  1
2014 De Bruin G, Li N, Paniagua G, Willems L, Xin BT, Verdoes M, Geurink P, Van Der Linden W, Van Der Stelt M, Van Der Marel G, Overkleeft H, Florea B. Activity-Based Proteasome Profiling in Medicinal Chemistry and Chemical Biology Concepts and Case Studies in Chemical Biology. 177-190. DOI: 10.1002/9783527687503.ch12  1
2013 Baggelaar MP, Janssen FJ, van Esbroeck AC, den Dulk H, Allarà M, Hoogendoorn S, McGuire R, Florea BI, Meeuwenoord N, van den Elst H, van der Marel GA, Brouwer J, Di Marzo V, Overkleeft HS, van der Stelt M. Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain. Angewandte Chemie (International Ed. in English). 52: 12081-5. PMID 24173880 DOI: 10.1002/anie.201306295  1
2013 Piwowarska NA, Banala S, Overkleeft HS, Süssmuth RD. Arg-Thz is a minimal substrate for the N(α),N(α)-arginyl methyltransferase involved in the biosynthesis of plantazolicin. Chemical Communications (Cambridge, England). 49: 10703-5. PMID 24100616 DOI: 10.1039/c3cc45898a  1
2013 Krawczyk B, van Herwerden EF, Overkleeft HS, Süssmuth RD. Elimination reactions of esters in the biosynthesis of polyketides and ribosomal peptides. Angewandte Chemie (International Ed. in English). 52: 9082-4. PMID 23934669 DOI: 10.1002/anie.201304851  1
2013 Yu H, Segers F, Sliedregt-Bol K, Bot I, Woltman AM, Boross P, Verbeek S, Overkleeft H, van der Marel GA, van Kooten C, van Berkel TJ, Biessen EA. Identification of a novel CD40 ligand for targeted imaging of inflammatory plaques by phage display. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4136-46. PMID 23896727 DOI: 10.1096/fj.12-224667  1
2013 van Rijssel ER, Goumans TP, Lodder G, Overkleeft HS, van der Marel GA, Codée JD. Chiral pyrroline-based Ugi-three-component reactions are under kinetic control. Organic Letters. 15: 3026-9. PMID 23721351 DOI: 10.1021/ol4012053  1
2013 Li N, Kuo CL, Paniagua G, van den Elst H, Verdoes M, Willems LI, van der Linden WA, Ruben M, van Genderen E, Gubbens J, van Wezel GP, Overkleeft HS, Florea BI. Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS. Nature Protocols. 8: 1155-68. PMID 23702832 DOI: 10.1038/nprot.2013.065  1
2013 Kistemaker HA, van Noort GJ, Overkleeft HS, van der Marel GA, Filippov DV. Stereoselective ribosylation of amino acids. Organic Letters. 15: 2306-9. PMID 23614697 DOI: 10.1021/ol400929c  1
2013 Gillis J, Schipper-Krom S, Juenemann K, Gruber A, Coolen S, Van Den Nieuwendijk R, Van Veen H, Overkleeft H, Goedhart J, Kampinga HH, Reits EA. The DNAJB6 and DNAJB8 protein chaperones prevent intracellular aggregation of polyglutamine peptides Journal of Biological Chemistry. 288: 17225-17237. PMID 23612975 DOI: 10.1074/jbc.M112.421685  1
2013 Castelli R, Overkleeft HS, van der Marel GA, Codée JD. 2,2-Dimethyl-4-(4-methoxy-phenoxy) butanoate and 2,2-dimethyl-4-azido butanoate: two new pivaloate-ester-like protecting groups. Organic Letters. 15: 2270-3. PMID 23607790 DOI: 10.1021/ol4008475  1
2013 van der Heden van Noort GJ, Schein CH, Overkleeft HS, van der Marel GA, Filippov DV. A general synthetic method toward uridylylated picornavirus VPg proteins. Journal of Peptide Science : An Official Publication of the European Peptide Society. 19: 333-6. PMID 23606631 DOI: 10.1002/psc.2508  1
2013 Geurink PP, van der Linden WA, Mirabella AC, Gallastegui N, de Bruin G, Blom AE, Voges MJ, Mock ED, Florea BI, van der Marel GA, Driessen C, van der Stelt M, Groll M, Overkleeft HS, Kisselev AF. Incorporation of non-natural amino acids improves cell permeability and potency of specific inhibitors of proteasome trypsin-like sites. Journal of Medicinal Chemistry. 56: 1262-75. PMID 23320547 DOI: 10.1021/jm3016987  1
2013 Gold H, Mirzaian M, Dekker N, Joao Ferraz M, Lugtenburg J, Codée JD, van der Marel GA, Overkleeft HS, Linthorst GE, Groener JE, Aerts JM, Poorthuis BJ. Quantification of globotriaosylsphingosine in plasma and urine of fabry patients by stable isotope ultraperformance liquid chromatography-tandem mass spectrometry. Clinical Chemistry. 59: 547-56. PMID 23237761 DOI: 10.1373/clinchem.2012.192138  1
2013 Walvoort MTC, Van Der Marel GA, Overkleeft HS, Codée JDC. On the reactivity and selectivity of donor glycosides in glycochemistry and glycobiology: Trapped covalent intermediates Chemical Science. 4: 897-906. DOI: 10.1039/c2sc21610h  1
2013 Otero JM, Van Der Knaap M, Llamas-Saiz AL, Van Raaij MJ, Amorín M, Granja JR, Filippov DV, Van Der Marel GA, Overkleeft HS, Overhand M. Design, synthesis, and structural analysis of turn modified cyclo-(αβ3αβ2α)2 peptide derivatives toward crystalline hexagon-shaped cationic nanochannel assemblies Crystal Growth and Design. 13: 4355-4367. DOI: 10.1021/cg4007108  1
2013 De Jong AR, Volbeda AG, Hagen B, Van Den Elst H, Overkleeft HS, Van Der Marel GA, Codée JDC. A second-generation tandem ring-closing metathesis cleavable linker for solid-phase oligosaccharide synthesis European Journal of Organic Chemistry. 6644-6655. DOI: 10.1002/ejoc.201301055  1
2012 Stolze SC, Deu E, Kaschani F, Li N, Florea BI, Richau KH, Colby T, van der Hoorn RA, Overkleeft HS, Bogyo M, Kaiser M. The antimalarial natural product symplostatin 4 is a nanomolar inhibitor of the food vacuole falcipains. Chemistry & Biology. 19: 1546-55. PMID 23261598 DOI: 10.1016/j.chembiol.2012.09.020  1
2012 Brouwer AJ, Jonker A, Werkhoven P, Kuo E, Li N, Gallastegui N, Kemmink J, Florea BI, Groll M, Overkleeft HS, Liskamp RM. Peptido sulfonyl fluorides as new powerful proteasome inhibitors. Journal of Medicinal Chemistry. 55: 10995-1003. PMID 23170994 DOI: 10.1021/jm301443r  1
2012 van der Knaap M, Basalan F, van de Mei HC, Busscher HJ, van der Marel GA, Overkleeft HS, Overhand M. Synthesis and biological evaluation of gramicidin S-inspired cyclic mixed α/β-peptides. Chemistry & Biodiversity. 9: 2494-506. PMID 23161631 DOI: 10.1002/cbdv.201200277  1
2012 Kallemeijn WW, Li KY, Witte MD, Marques AR, Aten J, Scheij S, Jiang J, Willems LI, Voorn-Brouwer TM, van Roomen CP, Ottenhoff R, Boot RG, van den Elst H, Walvoort MT, Florea BI, ... ... Overkleeft HS, et al. Novel activity-based probes for broad-spectrum profiling of retaining β-exoglucosidases in situ and in vivo. Angewandte Chemie (International Ed. in English). 51: 12529-33. PMID 23139194 DOI: 10.1002/anie.201207771  1
2012 Barroso S, Castelli R, Baggelaar MP, Geerdink D, ter Horst B, Casas-Arce E, Overkleeft HS, van der Marel GA, Codée JD, Minnaard AJ. Total synthesis of the triglycosyl phenolic glycolipid PGL-tb1 from Mycobacterium tuberculosis. Angewandte Chemie (International Ed. in English). 51: 11774-7. PMID 23086739 DOI: 10.1002/anie.201206221  1
2012 Gubbens J, Janus M, Florea BI, Overkleeft HS, van Wezel GP. Identification of glucose kinase-dependent and -independent pathways for carbon control of primary metabolism, development and antibiotic production in Streptomyces coelicolor by quantitative proteomics. Molecular Microbiology. 86: 1490-507. PMID 23078239 DOI: 10.1111/mmi.12072  1
2012 Lombardo E, van Roomen CP, van Puijvelde GH, Ottenhoff R, van Eijk M, Aten J, Kuiper J, Overkleeft HS, Groen AK, Verhoeven AJ, Aerts JM, Bietrix F. Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism. Plos One. 7: e38520. PMID 23056165 DOI: 10.1371/journal.pone.0038520  1
2012 Li J, Girard G, Florea BI, Geurink PP, Li N, van der Marel GA, Overhand M, Overkleeft HS, van Wezel GP. Identification and isolation of lantibiotics from culture: a bioorthogonal chemistry approach. Organic & Biomolecular Chemistry. 10: 8677-83. PMID 23033043 DOI: 10.1039/c2ob26050f  1
2012 Kapoerchan VV, Knijnenburg AD, Keizer P, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. 'Inverted' analogs of the antibiotic gramicidin S with an improved biological profile. Bioorganic & Medicinal Chemistry. 20: 6059-62. PMID 22989907 DOI: 10.1016/j.bmc.2012.08.038  1
2012 Walvoort MT, Kallemeijn WW, Willems LI, Witte MD, Aerts JM, van der Marel GA, Codée JD, Overkleeft HS. Tuning the leaving group in 2-deoxy-2-fluoroglucoside results in improved activity-based retaining β-glucosidase probes. Chemical Communications (Cambridge, England). 48: 10386-8. PMID 22932951 DOI: 10.1039/c2cc35653h  1
2012 van der Heden van Noort GJ, van Delft P, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Filippov DV. Fully automated sequential solid phase approach towards viral RNA-nucleopeptides. Chemical Communications (Cambridge, England). 48: 8093-5. PMID 22781550 DOI: 10.1039/c2cc33477a  1
2012 Walvoort MT, Volbeda AG, Reintjens NR, van den Elst H, Plante OJ, Overkleeft HS, van der Marel GA, Codée JD. Automated solid-phase synthesis of hyaluronan oligosaccharides. Organic Letters. 14: 3776-9. PMID 22780913 DOI: 10.1021/ol301666n  1
2012 Janssen KG, Li J, Hoang HT, Vulto P, van den Berg RJ, Overkleeft HS, Eijkel JC, Tas NR, van der Linden HJ, Hankemeier T. Limits of miniaturization: assessing ITP performance in sub-micron and nanochannels. Lab On a Chip. 12: 2888-93. PMID 22691967 DOI: 10.1039/c2lc21011h  1
2012 Willems LI, Li N, Florea BI, Ruben M, van der Marel GA, Overkleeft HS. Triple bioorthogonal ligation strategy for simultaneous labeling of multiple enzymatic activities. Angewandte Chemie (International Ed. in English). 51: 4431-4. PMID 22438272 DOI: 10.1002/anie.201200923  1
2012 Hogendorf WF, Kropec A, Filippov DV, Overkleeft HS, Huebner J, van der Marel GA, Codée JD. Light fluorous synthesis of glucosylated glycerol teichoic acids. Carbohydrate Research. 356: 142-51. PMID 22429772 DOI: 10.1016/j.carres.2012.02.023  1
2012 Christina AE, Blas Ferrando VM, de Bordes F, Spruit WA, Overkleeft HS, Codée JD, van der Marel GA. Multigram-scale synthesis of an orthogonally protected 2-acetamido-4-amino-2,4,6-trideoxy-D-galactose (AAT) building block. Carbohydrate Research. 356: 282-7. PMID 22418093 DOI: 10.1016/j.carres.2012.02.015  1
2012 Richau KH, Kaschani F, Verdoes M, Pansuriya TC, Niessen S, Stüber K, Colby T, Overkleeft HS, Bogyo M, Van der Hoorn RA. Subclassification and biochemical analysis of plant papain-like cysteine proteases displays subfamily-specific characteristics. Plant Physiology. 158: 1583-99. PMID 22371507 DOI: 10.1104/pp.112.194001  1
2012 Walvoort MT, van den Elst H, Plante OJ, Kröck L, Seeberger PH, Overkleeft HS, van der Marel GA, Codée JD. Automated solid-phase synthesis of β-mannuronic acid alginates. Angewandte Chemie (International Ed. in English). 51: 4393-6. PMID 22334421 DOI: 10.1002/anie.201108744  1
2012 Li N, Overkleeft HS, Florea BI. Activity-based protein profiling: an enabling technology in chemical biology research. Current Opinion in Chemical Biology. 16: 227-33. PMID 22325363 DOI: 10.1016/j.cbpa.2012.01.008  1
2012 Christina AE, van der Es D, Dinkelaar J, Overkleeft HS, van der Marel GA, Codée JD. β-Rhamnosides from 6-thio mannosides. Chemical Communications (Cambridge, England). 48: 2686-8. PMID 22306867 DOI: 10.1039/c2cc17623h  1
2012 Kisselev AF, van der Linden WA, Overkleeft HS. Proteasome inhibitors: an expanding army attacking a unique target. Chemistry & Biology. 19: 99-115. PMID 22284358 DOI: 10.1016/j.chembiol.2012.01.003  1
2012 Hogendorf WF, Lameijer LN, Beenakker TJ, Overkleeft HS, Filippov DV, Codée JD, Van der Marel GA. Fluorous linker facilitated synthesis of teichoic acid fragments. Organic Letters. 14: 848-51. PMID 22264133 DOI: 10.1021/ol2033652  1
2012 de Jong AR, Hagen B, van der Ark V, Overkleeft HS, Codée JD, Van der Marel GA. Exploring and exploiting the reactivity of glucuronic acid donors. The Journal of Organic Chemistry. 77: 108-25. PMID 22126096 DOI: 10.1021/jo201586r  1
2012 van der Linden WA, Willems LI, Shabaneh TB, Li N, Ruben M, Florea BI, van der Marel GA, Kaiser M, Kisselev AF, Overkleeft HS. Discovery of a potent and highly β1 specific proteasome inhibitor from a focused library of urea-containing peptide vinyl sulfones and peptide epoxyketones. Organic & Biomolecular Chemistry. 10: 181-94. PMID 22105930 DOI: 10.1039/c1ob06554h  1
2012 Geurink PP, Prely LM, van der Marel GA, Bischoff R, Overkleeft HS. Photoaffinity labeling in activity-based protein profiling. Topics in Current Chemistry. 324: 85-113. PMID 22028098 DOI: 10.1007/128_2011_286  1
2012 van der Linden WA, Li N, Hoogendoorn S, Ruben M, Verdoes M, Guo J, Boons GJ, van der Marel GA, Florea BI, Overkleeft HS. Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: a comparative study. Bioorganic & Medicinal Chemistry. 20: 662-6. PMID 21757357 DOI: 10.1016/j.bmc.2011.06.037  1
2012 Vrins CLJ, Bietrix F, Lombardo E, Van Roomen CPPA, Ottenhoff R, Overkleeft HS, Aerts JM. Glycosphingolipid synthesis inhibitor AMP-DNM lowers plasma cholesterol levels by promoting fecal cholesterol excretion without inhibiting cholesterol absorption Clinical Lipidology. 7: 241-248. DOI: 10.2217/clp.12.14  1
2012 Van Der Knaap M, Otero JM, Llamas-Saiz A, Van Raaij MJ, Lageveen LI, Busscher HJ, Grotenbreg GM, Van Der Marel GA, Overkleeft HS, Overhand M. Design, synthesis and structural analysis of mixed α/β-peptides that adopt stable cyclic hairpin-like conformations Tetrahedron. 68: 2391-2400. DOI: 10.1016/j.tet.2012.01.015  1
2012 Knijnenburg AD, Spalburg E, Deneeling AJ, Mars-Groenendijk RH, Noort D, Grotenbreg GM, Vandermarel GA, Overkleeft HS, Overhand M. Ring-extended gramicidin S analogs Containing cis δ-sugar amino acid turn mimetics with varying ring size Helvetica Chimica Acta. 95: 2544-2561. DOI: 10.1002/hlca.201200497  1
2012 Wennekes T, Bonger KM, Vogel K, Van Den Berg RJBHN, Strijland A, Donker-Koopman WE, Aerts JMFG, Van Der Marel GA, Overkleeft HS. The development of an aza-C-glycoside library based on a tandem staudinger/aza-wittig/ugi three-component reaction European Journal of Organic Chemistry. 6420-6454. DOI: 10.1002/ejoc.201200923  1
2012 Christina AE, Muns JA, Olivier JQA, Visser L, Hagen B, Van Den Bos LJ, Overkleeft HS, Codée JDC, Van Der Marel GA. On the reactivity and selectivity of galacturonic acid lactones European Journal of Organic Chemistry. 5729-5737. DOI: 10.1002/ejoc.201200717  1
2012 Van Den Nieuwendijk AMCH, Van Den Berg RJBHN, Ruben M, Witte MD, Brussee J, Boot RG, Van Der Marel GA, Aerts JMFG, Overkleeft HS. Synthesis of eight 1-deoxynojirimycin isomers from a single chiral cyanohydrin European Journal of Organic Chemistry. 3437-3446. DOI: 10.1002/ejoc.201200377  1
2011 van den Berg RJ, Wennekes T, Ghisaidoobe A, Donker-Koopman WE, Strijland A, Boot RG, van der Marel GA, Aerts JM, Overkleeft HS. Assessment of partially deoxygenated deoxynojirimycin derivatives as glucosylceramide synthase inhibitors. Acs Medicinal Chemistry Letters. 2: 519-22. PMID 24900342 DOI: 10.1021/ml200050s  1
2011 Ghisaidoobe A, Bikker P, de Bruijn AC, Godschalk FD, Rogaar E, Guijt MC, Hagens P, Halma JM, Van't Hart SM, Luitjens SB, van Rixel VH, Wijzenbroek M, Zweegers T, Donker-Koopman WE, Strijland A, ... ... Overkleeft HS, et al. Identification of potent and selective glucosylceramide synthase inhibitors from a library of N-alkylated iminosugars. Acs Medicinal Chemistry Letters. 2: 119-23. PMID 24900289 DOI: 10.1021/ml100192b  1
2011 Bonger KM, Hoogendoorn S, van Koppen CJ, Timmers CM, van der Marel GA, Overkleeft HS. Development of Selective LH Receptor Agonists by Heterodimerization with a FSH Receptor Antagonist. Acs Medicinal Chemistry Letters. 2: 85-9. PMID 24900256 DOI: 10.1021/ml100229v  1
2011 Smid BE, Rombach SM, Aerts JM, Kuiper S, Mirzaian M, Overkleeft HS, Poorthuis BJ, Hollak CE, Groener JE, Linthorst GE. Consequences of a global enzyme shortage of agalsidase beta in adult Dutch Fabry patients. Orphanet Journal of Rare Diseases. 6: 69. PMID 22041095 DOI: 10.1186/1750-1172-6-69  1
2011 Hoogendoorn S, Blom AE, Willems LI, van der Marel GA, Overkleeft HS. Synthesis of pH-activatable red fluorescent BODIPY dyes with distinct functionalities. Organic Letters. 13: 5656-9. PMID 21942639 DOI: 10.1021/ol202379w  1
2011 Aerts JM, Boot RG, van Eijk M, Groener J, Bijl N, Lombardo E, Bietrix FM, Dekker N, Groen AK, Ottenhoff R, van Roomen C, Aten J, Serlie M, Langeveld M, Wennekes T, ... Overkleeft HS, et al. Glycosphingolipids and insulin resistance. Advances in Experimental Medicine and Biology. 721: 99-119. PMID 21910085 DOI: 10.1007/978-1-4614-0650-1_7  1
2011 Willems LI, van der Linden WA, Li N, Li KY, Liu N, Hoogendoorn S, van der Marel GA, Florea BI, Overkleeft HS. Bioorthogonal chemistry: applications in activity-based protein profiling. Accounts of Chemical Research. 44: 718-29. PMID 21797256 DOI: 10.1021/ar200125k  1
2011 Walvoort MT, Moggré GJ, Lodder G, Overkleeft HS, Codée JD, van der Marel GA. Stereoselective synthesis of 2,3-diamino-2,3-dideoxy-β-D-mannopyranosyl uronates. The Journal of Organic Chemistry. 76: 7301-15. PMID 21793528 DOI: 10.1021/jo201179p  1
2011 Walvoort MT, de Witte W, van Dijk J, Dinkelaar J, Lodder G, Overkleeft HS, Codée JD, van der Marel GA. Mannopyranosyl uronic acid donor reactivity. Organic Letters. 13: 4360-3. PMID 21776974 DOI: 10.1021/ol2016862  1
2011 Witte MD, van der Marel GA, Aerts JM, Overkleeft HS. Irreversible inhibitors and activity-based probes as research tools in chemical glycobiology. Organic & Biomolecular Chemistry. 9: 5908-26. PMID 21769371 DOI: 10.1039/c1ob05531c  1
2011 Hoogendoorn S, Habets KL, Passemard S, Kuiper J, van der Marel GA, Florea BI, Overkleeft HS. Targeted pH-dependent fluorescent activity-based cathepsin probes. Chemical Communications (Cambridge, England). 47: 9363-5. PMID 21769329 DOI: 10.1039/c1cc12947c  1
2011 Hogendorf WF, Meeuwenoord N, Overkleeft HS, Filippov DV, Laverde D, Kropec A, Huebner J, Van der Marel GA, Codée JD. Automated solid phase synthesis of teichoic acids. Chemical Communications (Cambridge, England). 47: 8961-3. PMID 21734985 DOI: 10.1039/c1cc13132j  1
2011 Mirabella AC, Pletnev AA, Downey SL, Florea BI, Shabaneh TB, Britton M, Verdoes M, Filippov DV, Overkleeft HS, Kisselev AF. Specific cell-permeable inhibitor of proteasome trypsin-like sites selectively sensitizes myeloma cells to bortezomib and carfilzomib. Chemistry & Biology. 18: 608-18. PMID 21609842 DOI: 10.1016/j.chembiol.2011.02.015  1
2011 Geurink PP, Florea BI, Overkleeft HS. Activity-based profiling of 2-oxoglutarate oxygenases. Chemistry & Biology. 18: 557-9. PMID 21609835 DOI: 10.1016/j.chembiol.2011.05.002  1
2011 Knijnenburg AD, Kapoerchan VV, Grotenbreg GM, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, Ravensbergen B, Nibbering PH, van der Marel GA, Overkleeft HS, Overhand M. Synthesis and evaluation of strand and turn modified ring-extended gramicidin S derivatives. Bioorganic & Medicinal Chemistry. 19: 3402-9. PMID 21561781 DOI: 10.1016/j.bmc.2011.04.031  1
2011 van der Heden van Noort GJ, Overkleeft HS, van der Marel GA, Filippov DV. Ribosylation of adenosine: an orthogonally protected building block for the synthesis of ADP-ribosyl oligomers. Organic Letters. 13: 2920-3. PMID 21561136 DOI: 10.1021/ol200971z  1
2011 Witte MD, Walvoort MT, Li KY, Kallemeijn WW, Donker-Koopman WE, Boot RG, Aerts JM, Codée JD, van der Marel GA, Overkleeft HS. Activity-based profiling of retaining β-glucosidases: a comparative study. Chembiochem : a European Journal of Chemical Biology. 12: 1263-9. PMID 21538758 DOI: 10.1002/cbic.201000773  1
2011 Gold H, Munneke S, Dinkelaar J, Overkleeft HS, Aerts JM, Codée JD, van der Marel GA. A practical synthesis of capped 4-methylumbelliferyl hyaluronan disaccharides and tetrasaccharides as potential hyaluronidase substrates. Carbohydrate Research. 346: 1467-78. PMID 21536258 DOI: 10.1016/j.carres.2011.03.042  1
2011 Aerts JM, Kallemeijn WW, Wegdam W, Joao Ferraz M, van Breemen MJ, Dekker N, Kramer G, Poorthuis BJ, Groener JE, Cox-Brinkman J, Rombach SM, Hollak CE, Linthorst GE, Witte MD, Gold H, ... ... Overkleeft HS, et al. Biomarkers in the diagnosis of lysosomal storage disorders: proteins, lipids, and inhibodies. Journal of Inherited Metabolic Disease. 34: 605-19. PMID 21445610 DOI: 10.1007/s10545-011-9308-6  1
2011 van der Knaap M, Lageveen LT, Busscher HJ, Mars-Groenendijk R, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Evaluation of readily accessible azoles as mimics of the aromatic ring of D-phenylalanine in the turn region of gramicidin S. Chemmedchem. 6: 840-7. PMID 21400662 DOI: 10.1002/cmdc.201000539  1
2011 Knijnenburg AD, Tuin AW, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Exploring the conformational and biological versatility of β-turn-modified gramicidin S by using sugar amino acid homologues that vary in ring size. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 3995-4004. PMID 21365698 DOI: 10.1002/chem.201002895  1
2011 Christina AE, van den Bos LJ, Overkleeft HS, van der Marel GA, Codée JD. Galacturonic acid lactones in the synthesis of all trisaccharide repeating units of the zwitterionic polysaccharide Sp1. The Journal of Organic Chemistry. 76: 1692-706. PMID 21341806 DOI: 10.1021/jo102363d  1
2011 Codée JD, Christina AE, Walvoort MT, Overkleeft HS, van der Marel GA. Uronic acids in oligosaccharide and glycoconjugate synthesis. Topics in Current Chemistry. 301: 253-89. PMID 21222193 DOI: 10.1007/128_2010_111  1
2011 Kessler JH, Khan S, Seifert U, Le Gall S, Chow KM, Paschen A, Bres-Vloemans SA, De Ru A, Van Montfoort N, Franken KLMC, Benckhuijsen WE, Brooks JM, Van Hall T, Ray K, Mulder A, ... ... Overkleeft HS, et al. Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes Nature Immunology. 12: 45-53. PMID 21151101 DOI: 10.1038/ni.1974  1
2011 Kolodziejek I, Misas-Villamil JC, Kaschani F, Clerc J, Gu C, Krahn D, Niessen S, Verdoes M, Willems LI, Overkleeft HS, Kaiser M, van der Hoorn RA. Proteasome activity imaging and profiling characterizes bacterial effector syringolin A. Plant Physiology. 155: 477-89. PMID 21045122 DOI: 10.1104/pp.110.163733  1
2011 Clerc J, Li N, Krahn D, Groll M, Bachmann AS, Florea BI, Overkleeft HS, Kaiser M. The natural product hybrid of Syringolin A and Glidobactin A synergizes proteasome inhibition potency with subsite selectivity Chemical Communications. 47: 385-387. PMID 20830349 DOI: 10.1039/c0cc02238a  1
2011 Dekker N, Voorn-Brouwer T, Verhoek M, Wennekes T, Narayan RS, Speijer D, Hollak CE, Overkleeft HS, Boot RG, Aerts JM. The cytosolic β-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation. Blood Cells, Molecules & Diseases. 46: 19-26. PMID 20728381 DOI: 10.1016/j.bcmd.2010.07.009  1
2011 Codée JDC, Walvoort MTC, De Jong AR, Lodder G, Overkleeft HS, Van Der Marel GA. Mannuronic acids: Reactivity and selectivity Journal of Carbohydrate Chemistry. 30: 438-457. DOI: 10.1080/07328303.2011.624284  1
2011 Vandelft P, Vanschie E, Meeuwenoord NJ, Overkleeft HS, Van Der Marel GA, Filippov DV. Oligonucleotide conjugates by means of copper-free click chemistry - Expanding the repertoire of strained cyclooctyne phosphoramidites Synthesis. 2724-2732. DOI: 10.1055/s-0030-1260104  1
2011 Codée JDC, Ali A, Overkleeft HS, Van Der Marel GA. Novel protecting groups in carbohydrate chemistry Comptes Rendus Chimie. 14: 178-193. DOI: 10.1016/j.crci.2010.05.010  1
2011 Van Den Berg RJBHN, Van Den Elst H, Korevaar CGN, Aerts JMFG, Van Der Marel GA, Overkleeft HS. A rapid and efficient synthesis of D-erythro-sphingosine from D-ribo-phytosphingosine European Journal of Organic Chemistry. 6685-6689. DOI: 10.1002/ejoc.201100911  1
2011 Gold H, Boot RG, Aerts JMFG, Overkleeft HS, Codée JDC, Van Der Marel GA. A concise synthesis of globotriaosylsphingosine European Journal of Organic Chemistry. 1652-1663. DOI: 10.1002/ejoc.201001690  1
2010 Witte MD, Kallemeijn WW, Aten J, Li KY, Strijland A, Donker-Koopman WE, van den Nieuwendijk AM, Bleijlevens B, Kramer G, Florea BI, Hooibrink B, Hollak CE, Ottenhoff R, Boot RG, van der Marel GA, ... Overkleeft HS, et al. Ultrasensitive in situ visualization of active glucocerebrosidase molecules. Nature Chemical Biology. 6: 907-13. PMID 21079602 DOI: 10.1038/nchembio.466  1
2010 Walvoort MT, Lodder G, Overkleeft HS, Codée JD, van der Marel GA. Mannosazide methyl uronate donors. Glycosylating properties and use in the construction of β-ManNAcA-containing oligosaccharides. The Journal of Organic Chemistry. 75: 7990-8002. PMID 21062001 DOI: 10.1021/jo101779v  1
2010 van Delft P, Meeuwenoord NJ, Hoogendoorn S, Dinkelaar J, Overkleeft HS, van der Marel GA, Filippov DV. Synthesis of oligoribonucleic acid conjugates using a cyclooctyne phosphoramidite. Organic Letters. 12: 5486-9. PMID 21049910 DOI: 10.1021/ol102357u  1
2010 Geurink PP, Florea BI, Van der Marel GA, Kessler BM, Overkleeft HS. Probing the proteasome cavity in three steps: bio-orthogonal photo-reactive suicide substrates. Chemical Communications (Cambridge, England). 46: 9052-4. PMID 20981375 DOI: 10.1039/c0cc03322g  1
2010 Knijnenburg AD, Kapoerchan VV, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, van der Marel GA, Overkleeft HS, Overhand M. Tuning hydrophobicity of highly cationic tetradecameric Gramicidin S analogues using adamantane amino acids. Bioorganic & Medicinal Chemistry. 18: 8403-9. PMID 20951594 DOI: 10.1016/j.bmc.2010.09.018  1
2010 Altun M, Besche HC, Overkleeft HS, Piccirillo R, Edelmann MJ, Kessler BM, Goldberg AL, Ulfhake B. Muscle wasting in aged, sarcopenic rats is associated with enhanced activity of the ubiquitin proteasome pathway. The Journal of Biological Chemistry. 285: 39597-608. PMID 20940294 DOI: 10.1074/jbc.M110.129718  1
2010 Screen M, Britton M, Downey SL, Verdoes M, Voges MJ, Blom AE, Geurink PP, Risseeuw MD, Florea BI, van der Linden WA, Pletnev AA, Overkleeft HS, Kisselev AF. Nature of pharmacophore influences active site specificity of proteasome inhibitors. The Journal of Biological Chemistry. 285: 40125-34. PMID 20937826 DOI: 10.1074/jbc.M110.160606  1
2010 Kapoerchan VV, Knijnenburg AD, Niamat M, Spalburg E, de Neeling AJ, Nibbering PH, Mars-Groenendijk RH, Noort D, Otero JM, Llamas-Saiz AL, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. An adamantyl amino acid containing gramicidin S analogue with broad spectrum antibacterial activity and reduced hemolytic activity. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 12174-81. PMID 20848624 DOI: 10.1002/chem.201001686  1
2010 Florea BI, Verdoes M, Li N, van der Linden WA, Geurink PP, van den Elst H, Hofmann T, de Ru A, van Veelen PA, Tanaka K, Sasaki K, Murata S, den Dulk H, Brouwer J, Ossendorp FA, ... ... Overkleeft HS, et al. Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t. Chemistry & Biology. 17: 795-801. PMID 20797608 DOI: 10.1016/j.chembiol.2010.05.027  1
2010 Geurink PP, Florea BI, Li N, Witte MD, Verasdonck J, Kuo CL, van der Marel GA, Overkleeft HS. A cleavable linker based on the levulinoyl ester for activity-based protein profiling. Angewandte Chemie (International Ed. in English). 49: 6802-5. PMID 20715027 DOI: 10.1002/anie.201001767  1
2010 van der Heden van Noort GJ, Overkleeft HS, van der Marel GA, Filippov DV. Synthesis of nucleotidylated poliovirus VPg proteins. The Journal of Organic Chemistry. 75: 5733-6. PMID 20704445 DOI: 10.1021/jo100757t  1
2010 van den Nieuwendijk AM, Ruben M, Engelsma SE, Risseeuw MD, van den Berg RJ, Boot RG, Aerts JM, Brussee J, van der Marel GA, Overkleeft HS. Synthesis of L-altro-1-deoxynojirimycin, D-allo-1-deoxynojirimycin, and D-galacto-1-deoxynojirimycin from a single chiral cyanohydrin. Organic Letters. 12: 3957-9. PMID 20690611 DOI: 10.1021/ol101556k  1
2010 Willems LI, Verdoes M, Florea BI, van der Marel GA, Overkleeft HS. Two-step labeling of endogenous enzymatic activities by Diels-Alder ligation. Chembiochem : a European Journal of Chemical Biology. 11: 1769-81. PMID 20623570 DOI: 10.1002/cbic.201000280  1
2010 Risseeuw MD, Florea BI, van der Marel GA, Overkleeft HS, Overhand M. Sugar amino acid based peptide epoxyketones as potential proteasome inhibitors. Bioorganic Chemistry. 38: 202-9. PMID 20493511 DOI: 10.1016/j.bioorg.2010.04.004  1
2010 Verdoes M, Willems LI, van der Linden WA, Duivenvoorden BA, van der Marel GA, Florea BI, Kisselev AF, Overkleeft HS. A panel of subunit-selective activity-based proteasome probes. Organic & Biomolecular Chemistry. 8: 2719-27. PMID 20449511 DOI: 10.1039/c001036g  1
2010 van der Linden WA, Geurink PP, Oskam C, van der Marel GA, Florea BI, Overkleeft HS. Proteasome selectivity towards Michael acceptor containing oligopeptide-based inhibitors. Organic & Biomolecular Chemistry. 8: 1885-93. PMID 20449494 DOI: 10.1039/b924134e  1
2010 Bonger KM, Kapoerchan VV, Grotenbreg GM, van Koppen CJ, Timmers CM, van der Marel GA, Overkleeft HS. Oligoproline helices as structurally defined scaffolds for oligomeric G protein-coupled receptor ligands. Organic & Biomolecular Chemistry. 8: 1881-4. PMID 20449493 DOI: 10.1039/b923556f  1
2010 Hogendorf WFJ, Bos LJVd, Overkleeft HS, Codée JDC, Marel GAVd. Synthesis of an α-kojibiosyl substituted glycerol teichoic acid hexamer Bioorganic and Medicinal Chemistry. 18: 3668-3678. PMID 20409722 DOI: 10.1016/j.bmc.2010.03.071  1
2010 Walvoort MT, Dinkelaar J, van den Bos LJ, Lodder G, Overkleeft HS, Codée JD, van der Marel GA. The impact of oxacarbenium ion conformers on the stereochemical outcome of glycosylations. Carbohydrate Research. 345: 1252-63. PMID 20347068 DOI: 10.1016/j.carres.2010.02.027  1
2010 van der Heden van Noort GJ, van der Horst MG, Overkleeft HS, van der Marel GA, Filippov DV. Synthesis of mono-ADP-ribosylated oligopeptides using ribosylated amino acid building blocks. Journal of the American Chemical Society. 132: 5236-40. PMID 20232863 DOI: 10.1021/ja910940q  1
2010 Kapoerchan VV, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Otero JM, Ferraces-Casais P, Llamas-Saiz AL, van Raaij MJ, van Doorn J, van der Marel GA, Overkleeft HS, Overhand M. Gramicidin S derivatives containing cis- and trans-morpholine amino acids (MAAs) as turn mimetics. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 4259-65. PMID 20209520 DOI: 10.1002/chem.200902984  1
2010 Geurink PP, Liu N, Spaans MP, Downey SL, van den Nieuwendijk AM, van der Marel GA, Kisselev AF, Florea BI, Overkleeft HS. Incorporation of fluorinated phenylalanine generates highly specific inhibitor of proteasome's chymotrypsin-like sites. Journal of Medicinal Chemistry. 53: 2319-23. PMID 20131905 DOI: 10.1021/jm9015685  1
2010 Gu C, Kolodziejek I, Misas-Villamil J, Shindo T, Colby T, Verdoes M, Richau KH, Schmidt J, Overkleeft HS, van der Hoorn RA. Proteasome activity profiling: a simple, robust and versatile method revealing subunit-selective inhibitors and cytoplasmic, defense-induced proteasome activities. The Plant Journal : For Cell and Molecular Biology. 62: 160-70. PMID 20042019 DOI: 10.1111/j.1365-313X.2009.04122.x  1
2010 Wennekes T, Meijer AJ, Groen AK, Boot RG, Groener JE, van Eijk M, Ottenhoff R, Bijl N, Ghauharali K, Song H, O'Shea TJ, Liu H, Yew N, Copeland D, van den Berg RJ, ... ... Overkleeft HS, et al. Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. Journal of Medicinal Chemistry. 53: 689-98. PMID 20000679 DOI: 10.1021/jm901281m  1
2010 Kapoerchan VV, Wiesner M, Hillaert U, Drijfhout JW, Overhand M, Alard P, van der Marel GA, Overkleeft HS, Koning F. Design, synthesis and evaluation of high-affinity binders for the celiac disease associated HLA-DQ2 molecule. Molecular Immunology. 47: 1091-7. PMID 19962195 DOI: 10.1016/j.molimm.2009.10.036  1
2010 van Scherpenzeel M, van den Berg RJ, Donker-Koopman WE, Liskamp RM, Aerts JM, Overkleeft HS, Pieters RJ. Nanomolar affinity, iminosugar-based chemical probes for specific labeling of lysosomal glucocerebrosidase. Bioorganic & Medicinal Chemistry. 18: 267-73. PMID 19931460 DOI: 10.1016/j.bmc.2009.10.060  1
2010 Ali A, Van Den Berg RJBHN, Overkleeft HS, Van Der Marel GA, Codée JDC. The methylsulfonylethoxymethyl (Msem) as a hydroxyl protecting group in oligosaccharide synthesis Tetrahedron. 66: 6121-6132. DOI: 10.1016/j.tet.2010.06.007  1
2010 Dinkelaar J, Duivenvoorden BA, Wennekes T, Overkleeft HS, Boot RG, Aerts JMFG, Codée JDC, Van Der Marel GA. A preparative synthesis of human chitinase fluorogenic substrate (4' -deoxychitobiosyl)-4-methylumbelliferone European Journal of Organic Chemistry. 2565-2570. DOI: 10.1002/ejoc.201000080  1
2010 Geurink PP, Klein T, Prèly L, Paal K, Leeuwenburgh MA, Van Der Marel GA, Kauffman HF, Overkleeft HS, Bischoff R. Design of peptide hydroxamate-based photoreactive activity-based probes of zinc-dependent metalloproteases European Journal of Organic Chemistry. 2100-2112. DOI: 10.1002/ejoc.200901385  1
2010 Wennekes T, Van Den Berg RJBHN, Boltje TJ, Donker-Koopman WE, Kuijper B, Van Der Marel GA, Strijland A, Verhagen CP, Aerts JMFG, Overkleeft HS. Synthesis and evaluation of lipophilic Aza-C-glycosides as inhibitors of glucosylceramide metabolism European Journal of Organic Chemistry. 1258-1283. DOI: 10.1002/ejoc.200901208  1
2009 Britton M, Lucas MM, Downey SL, Screen M, Pletnev AA, Verdoes M, Tokhunts RA, Amir O, Goddard AL, Pelphrey PM, Wright DL, Overkleeft HS, Kisselev AF. Selective inhibitor of proteasome's caspase-like sites sensitizes cells to specific inhibition of chymotrypsin-like sites. Chemistry & Biology. 16: 1278-89. PMID 20064438 DOI: 10.1016/j.chembiol.2009.11.015  1
2009 Bonger KM, Hoogendoorn S, van Koppen CJ, Timmers CM, Overkleeft HS, van der Marel GA. Synthesis and pharmacological evaluation of dimeric follicle-stimulating hormone receptor antagonists. Chemmedchem. 4: 2098-102. PMID 19902448 DOI: 10.1002/cmdc.200900344  1
2009 Knijnenburg AD, Spalburg E, de Neeling AJ, Mars-Groenendijk RH, Noort D, Grotenbreg GM, van der Marel GA, Overkleeft HS, Overhand M. Ring-extended derivatives of gramicidin S with furanoid sugar amino acids in the turn region have enhanced antimicrobial activity. Chemmedchem. 4: 1976-9. PMID 19862783 DOI: 10.1002/cmdc.200900379  1
2009 Wennekes T, van den Berg RJ, Boot RG, van der Marel GA, Overkleeft HS, Aerts JM. Glycosphingolipids--nature, function, and pharmacological modulation. Angewandte Chemie (International Ed. in English). 48: 8848-69. PMID 19862781 DOI: 10.1002/anie.200902620  1
2009 Risseeuw MD, van den Berg RJ, Donker-Koopman WE, van der Marel GA, Aerts JM, Overhand M, Overkleeft HS. Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 6600-3. PMID 19853441 DOI: 10.1016/j.bmcl.2009.10.022  1
2009 Clerc J, Florea BI, Kraus M, Groll M, Huber R, Bachmann AS, Dudler R, Driessen C, Overkleeft HS, Kaiser M. Syringolin A selectively labels the 20 S proteasome in murine EL4 and wild-type and bortezomib-adapted leukaemic cell lines. Chembiochem : a European Journal of Chemical Biology. 10: 2638-43. PMID 19746508 DOI: 10.1002/cbic.200900411  1
2009 Maynard CJ, Böttcher C, Ortega Z, Smith R, Florea BI, Díaz-Hernández M, Brundin P, Overkleeft HS, Li JY, Lucas JJ, Dantuma NP. Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment. Proceedings of the National Academy of Sciences of the United States of America. 106: 13986-91. PMID 19666572 DOI: 10.1073/pnas.0906463106  1
2009 Walvoort MT, Lodder G, Mazurek J, Overkleeft HS, Codée JD, van der Marel GA. Equatorial anomeric triflates from mannuronic acid esters. Journal of the American Chemical Society. 131: 12080-1. PMID 19663422 DOI: 10.1021/ja905008p  1
2009 Witte MD, Florea BI, Verdoes M, Adeyanju O, Van Der Marel GA, Overkleeft HS. O-GlcNAc peptide epoxyketones are recognized by mammalian proteasomes Journal of the American Chemical Society. 131: 12064-12065. PMID 19658393 DOI: 10.1021/ja901231w  1
2009 Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, van Koppen CJ, Timmers CM, Overkleeft HS, van der Marel GA. Discovery of selective luteinizing hormone receptor agonists using the bivalent ligand method. Chemmedchem. 4: 1189-95. PMID 19475639 DOI: 10.1002/cmdc.200900058  1
2009 van Eijk M, Aten J, Bijl N, Ottenhoff R, van Roomen CP, Dubbelhuis PF, Seeman I, Ghauharali-van der Vlugt K, Overkleeft HS, Arbeeny C, Groen AK, Aerts JM. Reducing glycosphingolipid content in adipose tissue of obese mice restores insulin sensitivity, adipogenesis and reduces inflammation. Plos One. 4: e4723. PMID 19305508 DOI: 10.1371/journal.pone.0004723  1
2009 Tuin AW, Mol MA, van den Berg RM, Fidder A, van der Marel GA, Overkleeft HS, Noort D. Activity-Based Protein Profiling Reveals Broad Reactivity of the Nerve Agent Sarin. Chemical Research in Toxicology. 22: 683-9. PMID 19226147 DOI: 10.1021/tx8004218  1
2009 Hillaert U, Verdoes M, Florea BI, Saragliadis A, Saragliadis A, Habets KL, Kuiper J, Van Calenbergh S, Ossendorp F, van der Marel GA, Driessen C, Overkleeft HS. Receptor-mediated targeting of cathepsins in professional antigen presenting cells. Angewandte Chemie (International Ed. in English). 48: 1629-32. PMID 19156780 DOI: 10.1002/anie.200805529  1
2009 de Nooijer R, Bot I, von der Thüsen JH, Leeuwenburgh MA, Overkleeft HS, Kraaijeveld AO, Dorland R, van Santbrink PJ, van Heiningen SH, Westra MM, Kovanen PT, Jukema JW, van der Wall EE, van Berkel TJ, Shi GP, et al. Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 29: 188-94. PMID 19095996 DOI: 10.1161/ATVBAHA.108.181578  1
2009 Khan S, Weterings JJ, Britten CM, de Jong AR, Graafland D, Melief CJ, van der Burg SH, van der Marel G, Overkleeft HS, Filippov DV, Ossendorp F. Chirality of TLR-2 ligand Pam3CysSK4 in fully synthetic peptide conjugates critically influences the induction of specific CD8+ T-cells. Molecular Immunology. 46: 1084-91. PMID 19027958 DOI: 10.1016/j.molimm.2008.10.006  1
2009 Hogendorf WFJ, Verhagen CP, Malta E, Goosen N, Overkleeft HS, Filippov DV, Van der Marel GA. The synthesis of a menthol derivative of 2-aminopurine as a fluorescent DNA lesion Tetrahedron. 65: 10430-10435. DOI: 10.1016/j.tet.2009.10.023  1
2008 Gold H, Van Delft P, Meeuwenoord N, Codée JDC, Filippov DV, Eggink G, Overkleeft HS, Van Der Marel GA. Synthesis of sugar nucleotides by application of phosphoramidites Journal of Organic Chemistry. 73: 9458-9460. PMID 18991380 DOI: 10.1021/jo802021t  1
2008 Abello N, Geurink PP, van der Toorn M, van Oosterhout AJ, Lugtenburg J, van der Marel GA, Kerstjens HA, Postma DS, Overkleeft HS, Bischoff R. Poly(ethylene glycol)-based stable isotope labeling reagents for the quantitative analysis of low molecular weight metabolites by LC-MS. Analytical Chemistry. 80: 9171-80. PMID 18954088 DOI: 10.1021/ac801215c  1
2008 Bonger KM, van den Berg RJ, Knijnenburg AD, Heitman LH, Ijzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA. Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core. Bioorganic & Medicinal Chemistry. 16: 3744-58. PMID 18282756 DOI: 10.1016/j.bmc.2008.01.054  1
2007 Bonger KM, van den Berg RJ, Heitman LH, IJzerman AP, Oosterom J, Timmers CM, Overkleeft HS, van der Marel GA. Synthesis and evaluation of homo-bivalent GnRHR ligands. Bioorganic & Medicinal Chemistry. 15: 4841-56. PMID 17517510 DOI: 10.1016/j.bmc.2007.04.065  1
2007 Khan S, Bijker MS, Weterings JJ, Tanke HJ, Adema GJ, van Hall T, Drijfhout JW, Melief CJ, Overkleeft HS, van der Marel GA, Filippov DV, van der Burg SH, Ossendorp F. Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. The Journal of Biological Chemistry. 282: 21145-59. PMID 17462991 DOI: 10.1074/jbc.M701705200  1
2007 van Swieten PF, Samuel E, Hernández RO, van den Nieuwendijk AM, Leeuwenburgh MA, van der Marel GA, Kessler BM, Overkleeft HS, Kisselev AF. A cell-permeable inhibitor and activity-based probe for the caspase-like activity of the proteasome. Bioorganic & Medicinal Chemistry Letters. 17: 3402-5. PMID 17442566 DOI: 10.1016/j.bmcl.2007.03.092  1
2007 Aerts JM, Ottenhoff R, Powlson AS, Grefhorst A, van Eijk M, Dubbelhuis PF, Aten J, Kuipers F, Serlie MJ, Wennekes T, Sethi JK, O'Rahilly S, Overkleeft HS. Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity. Diabetes. 56: 1341-9. PMID 17287460 DOI: 10.2337/db06-1619  1
2007 Wennekes T, van den Berg RJ, Donker W, van der Marel GA, Strijland A, Aerts JM, Overkleeft HS. Development of adamantan-1-yl-methoxy-functionalized 1-deoxynojirimycin derivatives as selective inhibitors of glucosylceramide metabolism in man. The Journal of Organic Chemistry. 72: 1088-97. PMID 17243712 DOI: 10.1021/jo061280p  1
2007 Agrawal PR, Hofmann MW, Meeuwenoord NJ, Filippov DV, Stalz H, Hulsbergen F, Langosch D, Overkleeft HS, De Groot H. Solid-phase synthesis and purification of a set of uniformly 13C, 15N labelled de novo designed membrane fusogenic peptides. Journal of Peptide Science : An Official Publication of the European Peptide Society. 13: 75-80. PMID 17121421 DOI: 10.1002/psc.786  1
2007 Boot RG, Verhoek M, Donker-Koopman W, Strijland A, van Marle J, Overkleeft HS, Wennekes T, Aerts JM. Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2. The Journal of Biological Chemistry. 282: 1305-12. PMID 17105727 DOI: 10.1074/jbc.M610544200  1
2006 Grotenbreg GM, Buizert AE, Llamas-Saiz AL, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Raaij MJ, van der Marel GA, Overkleeft HS, Overhand M. Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product. Journal of the American Chemical Society. 128: 7559-65. PMID 16756311 DOI: 10.1021/ja0588510  1
2006 Tuin AW, Siegal G, van der Marel GA, Overkleeft HS, Filippov DV. Facile synthesis and application of uniformly 13C, 15N-labeled phosphotyrosine for ligand binding studies Bioorganic and Medicinal Chemistry Letters. 16: 3806-3808. PMID 16650988 DOI: 10.1016/j.bmcl.2006.04.021  1
2006 Slegt M, Gronheid R, van der Vlugt D, Ochiai M, Okuyama T, Zuilhof H, Overkleeft HS, Lodder G. Photochemical generation of six- and five-membered cyclic vinyl cations. The Journal of Organic Chemistry. 71: 2227-35. PMID 16526767 DOI: 10.1021/jo0518957  1
2005 El Oualid F, van den Elst H, Leroy IM, Pieterman E, Cohen LH, Burm BE, Overkleeft HS, van der Marel GA, Overhand M. A combinatorial approach toward the generation of ambiphilic peptide-based inhibitors of protein:geranylgeranyl transferase-1. Journal of Combinatorial Chemistry. 7: 703-13. PMID 16153065 DOI: 10.1021/cc0500203  1
2005 van Zutphen S, Stone EA, van Rijt S, Robillard MS, van der Marel GA, Overkleeft HS, den Dulk H, Brouwer J, Reedijk J. Combinatorial discovery of new asymmetric cis platinum anticancer complexes is made possible with solid-phase synthetic methods. Journal of Inorganic Biochemistry. 99: 2032-8. PMID 16099049 DOI: 10.1016/j.jinorgbio.2005.06.033  1
2005 van Zutphen S, Kraus M, Driessen C, van der Marel GA, Overkleeft HS, Reedijk J. Probing the potential of platinum(II) complexes for the inhibition of thiol-dependent enzymatic activity. Journal of Inorganic Biochemistry. 99: 1384-9. PMID 15869797 DOI: 10.1016/j.jinorgbio.2005.03.014  1
2005 Codée JD, Stubba B, Schiattarella M, Overkleeft HS, van Boeckel CA, van Boom JH, van der Marel GA. A modular strategy toward the synthesis of heparin-like oligosaccharides using monomeric building blocks in a sequential glycosylation strategy. Journal of the American Chemical Society. 127: 3767-73. PMID 15771511 DOI: 10.1021/ja045613g  1
2005 Grotenbreg GM, Witte MD, van Hoof PA, Spalburg E, Reiss P, Noort D, de Neeling AJ, Koert U, van der Marel GA, Overkleeft HS, Overhand M. Synthesis and biological evaluation of gramicidin S dimers. Organic & Biomolecular Chemistry. 3: 233-8. PMID 15717418 DOI: 10.1039/b414618b  1
2005 El Oualid F, Baktawar J, Leroy IM, van den Elst H, Cohen LH, van der Marel GA, Overkleeft HS, Overhand M. Synthesis and biological evaluation of lipophilic Ca(1)a(2)L analogues as potential bisubstrate inhibitors of protein:geranylgeranyl transferase-1. Bioorganic & Medicinal Chemistry. 13: 1463-75. PMID 15698762 DOI: 10.1016/j.bmc.2004.12.035  1
2005 Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European Journal of Chemical Biology. 6: 287-91. PMID 15651044 DOI: 10.1002/cbic.200400236  1
2004 Grotenbreg GM, Christina AE, Buizert AE, van der Marel GA, Overkleeft HS, Overhand M. Synthesis and application of carbohydrate-derived morpholine amino acids. The Journal of Organic Chemistry. 69: 8331-9. PMID 15549804 DOI: 10.1021/jo048630x  1
2004 Welters MJ, Filippov DV, van den Eeden SJ, Franken KL, Nouta J, Valentijn AR, van der Marel GA, Overkleeft HS, Lipford G, Offringa R, Melief CJ, van Boom JH, van der Burg SH, Drijfhout JW. Chemically synthesized protein as tumour-specific vaccine: immunogenicity and efficacy of synthetic HPV16 E7 in the TC-1 mouse tumour model. Vaccine. 23: 305-11. PMID 15530672 DOI: 10.1016/j.vaccine.2004.06.008  1
2004 Grotenbreg GM, Kronemeijer M, Timmer MS, El Oualid F, van Well RM, Verdoes M, Spalburg E, van Hooft PA, de Neeling AJ, Noort D, van Boom JH, van der Marel GA, Overkleeft HS, Overhand M. A practical synthesis of gramicidin s and sugar amino Acid containing analogues. The Journal of Organic Chemistry. 69: 7851-9. PMID 15527261 DOI: 10.1021/jo0487449  1
2004 Raunkjaer M, El Oualid F, van der Marel GA, Overkleeft HS, Overhand M. Alkylated sugar amino acids: a new entry toward highly functionalized dipeptide isosters. Organic Letters. 6: 3167-70. PMID 15330614 DOI: 10.1021/ol048750r  1
2004 van den Berg RJ, Korevaar CG, Overkleeft HS, van der Marel GA, van Boom JH. Effective, high-yielding, and stereospecific total synthesis of D-erythro-(2R,3S)-sphingosine from D-ribo-(2S,3S,4R)-phytosphingosine. The Journal of Organic Chemistry. 69: 5699-704. PMID 15307742 DOI: 10.1021/jo049277y  1
2004 El Oualid F, Burm BE, Leroy IM, Cohen LH, van Boom JH, van den Elst H, Overkleeft HS, van der Marel GA, Overhand M. Design, synthesis, and evaluation of sugar amino acid based inhibitors of protein prenyl transferases PFT and PGGT-1. Journal of Medicinal Chemistry. 47: 3920-3. PMID 15267228 DOI: 10.1021/jm049927q  1
2004 Tromp RA, van Boom SS, Marco Timmers C, van Zutphen S, van der Marel GA, Overkleeft HS, van Boom JH, Reedijk J. The beta-glucuronyl-based prodrug strategy allows for its application on beta-glucuronyl-platinum conjugates. Bioorganic & Medicinal Chemistry Letters. 14: 4273-6. PMID 15261285 DOI: 10.1016/j.bmcl.2004.06.015  1
2004 van den Bos LJ, Codée JD, van der Toorn JC, Boltje TJ, van Boom JH, Overkleeft HS, van der Marel GA. Thioglycuronides: synthesis and application in the assembly of acidic oligosaccharides. Organic Letters. 6: 2165-8. PMID 15200311 DOI: 10.1021/ol049380+  1
2004 van Swieten PF, Maehr R, van den Nieuwendijk AM, Kessler BM, Reich M, Wong CS, Kalbacher H, Leeuwenburgh MA, Driessen C, van der Marel GA, Ploegh HL, Overkleeft HS. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 14: 3131-4. PMID 15149659 DOI: 10.1016/j.bmcl.2004.04.046  1
2004 van Hooft PA, El Oualid F, Overkleeft HS, van der Marel GA, van Boom JH, Leeuwenburgh MA. Synthesis and elaboration of functionalised carbohydrate-derived spiroketals. Organic & Biomolecular Chemistry. 2: 1395-403. PMID 15105932 DOI: 10.1039/b401699h  1
2004 Grotenbreg GM, Timmer MS, Llamas-Saiz AL, Verdoes M, van der Marel GA, van Raaij MJ, Overkleeft HS, Overhand M. An unusual reverse turn structure adopted by a furanoid sugar amino acid incorporated in gramicidin S. Journal of the American Chemical Society. 126: 3444-6. PMID 15025470 DOI: 10.1021/ja0397254  1
2003 van den Bos LJ, Codée JD, van Boom JH, Overkleeft HS, van der Marel GA. A novel strategy towards the synthesis of orthogonally functionalised 4-aminoglycosides. Organic & Biomolecular Chemistry. 1: 4160-5. PMID 14685319 DOI: 10.1039/b309823k  1
2003 Verhelst SH, Paez Martinez B, Timmer MS, Lodder G, van der Marel GA, Overkleeft HS, van Boom JH. A short route toward chiral, polyhydroxylated indolizidines and quinolizidines. The Journal of Organic Chemistry. 68: 9598-603. PMID 14656083 DOI: 10.1021/jo0350662  1
2003 Timmer MS, Verdoes M, Sliedregt LA, van der Marel GA, van Boom JH, Overkleeft HS. The use of a mannitol-derived fused oxacycle as a combinatorial scaffold. The Journal of Organic Chemistry. 68: 9406-11. PMID 14629165 DOI: 10.1021/jo0349429  1
2003 Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Molecular & Cellular Proteomics : McP. 2: 1188-97. PMID 13130081 DOI: 10.1074/mcp.M300067-MCP200  1
2003 Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angewandte Chemie (International Ed. in English). 42: 3626-9. PMID 12916032 DOI: 10.1002/anie.200351314  1
2003 Aguilera B, Ghauharali-van der Vlugt K, Helmond MT, Out JM, Donker-Koopman WE, Groener JE, Boot RG, Renkema GH, van der Marel GA, van Boom JH, Overkleeft HS, Aerts JM. Transglycosidase activity of chitotriosidase: improved enzymatic assay for the human macrophage chitinase. The Journal of Biological Chemistry. 278: 40911-6. PMID 12890686 DOI: 10.1074/jbc.M301804200  1
2003 Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. The Journal of Biological Chemistry. 278: 35869-77. PMID 12815064 DOI: 10.1074/jbc.M303725200  1
2003 Grotenbreg GM, Spalburg E, de Neeling AJ, van der Marel GA, Overkleeft HS, van Boom JH, Overhand M. Synthesis and biological evaluation of novel turn-modified gramicidin S analogues. Bioorganic & Medicinal Chemistry. 11: 2835-41. PMID 12788356  1
2003 Codée JD, van den Bos LJ, Litjens RE, Overkleeft HS, van Boom JH, van der Marel GA. Sequential one-pot glycosylations using 1-hydroxyl and 1-thiodonors. Organic Letters. 5: 1947-50. PMID 12762693 DOI: 10.1021/ol034528v  1
2003 de Visser PC, Kriek NM, van Hooft PA, Van Schepdael A, Filippov DV, van der Marel GA, Overkleeft HS, van Boom JH, Noort D. Solid-phase synthesis of polymyxin B1 and analogues via a safety-catch approach. The Journal of Peptide Research : Official Journal of the American Peptide Society. 61: 298-306. PMID 12753377 DOI: 10.1034/j.1399-3011.2003.00061.x  1
2003 Codée JD, Litjens RE, den Heeten R, Overkleeft HS, van Boom JH, van der Marel GA. Ph2SO/Tf2O: a powerful promotor system in chemoselective glycosylations using thioglycosides. Organic Letters. 5: 1519-22. PMID 12713313 DOI: 10.1021/ol034312t  1
2003 van Zutphen S, Robillard MS, van der Marel GA, Overkleeft HS, den Dulk H, Brouwer J, Reedijk J. Extending solid-phase methods in inorganic synthesis: the first dinuclear platinum complex synthesised via the solid phase. Chemical Communications (Cambridge, England). 634-5. PMID 12669861  1
2003 van Well RM, Overkleeft HS, van der Marel GA, Bruss D, Thibault G, de Groot PG, van Boom JH, Overhand M. Solid-phase synthesis of cyclic RGD-furanoid sugar amino acid peptides as integrin inhibitors. Bioorganic & Medicinal Chemistry Letters. 13: 331-4. PMID 12565923  1
2002 Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. The Journal of Experimental Medicine. 196: 529-40. PMID 12186844  1
2001 Borodovsky A, Kessler BM, Casagrande R, Overkleeft HS, Wilkinson KD, Ploegh HL. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. The Embo Journal. 20: 5187-96. PMID 11566882 DOI: 10.1093/emboj/20.18.5187  1
2001 Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chemistry & Biology. 8: 913-29. PMID 11564559  1
2001 Lennon-Duménil AM, Roberts RA, Valentijn K, Driessen C, Overkleeft HS, Erickson A, Peters PJ, Bikoff E, Ploegh HL, Wolf Bryant P. The p41 isoform of invariant chain is a chaperone for cathepsin L. The Embo Journal. 20: 4055-64. PMID 11483509 DOI: 10.1093/emboj/20.15.4055  1
2001 Aguilera B, Wolf LB, Nieczypor P, Rutjes FP, Overkleeft HS, van Hest JC, Schoemaker HE, Wang B, Mol JC, Fürstner A, Overhand M, van der Marel GA, van Boom JH. Synthesis of diaminosuberic acid derivatives via ring-closing alkyne metathesis. The Journal of Organic Chemistry. 66: 3584-9. PMID 11348148 DOI: 10.1021/jo001734x  1
2000 Leeuwenburgh MA, Litjens RE, Codee JD, Overkleeft HS, van der Marel GA, van Boom JH. Radical cyclization of sugar-derived beta-(alkynyloxy)acrylates: synthesis of novel fused ethers Organic Letters. 2: 1275-7. PMID 10810726  1
1998 Overkleeft HS, Renkema GH, Neele J, Vianello P, Hung IO, Strijland A, van der Burg AM, Koomen GJ, Pandit UK, Aerts JM. Generation of specific deoxynojirimycin-type inhibitors of the non-lysosomal glucosylceramidase. The Journal of Biological Chemistry. 273: 26522-7. PMID 9756888 DOI: 10.1074/jbc.273.41.26522  1
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