Johannes L. Bos - Publications

Affiliations: 
Physiological Chemistry Utrecht University, Utrecht, Netherlands 
Area:
Ras mutations in human tumors
Website:
http://knaw.nl/nl/leden/leden/3924

155 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Post JB, Hami N, Mertens AEE, Elfrink S, Bos JL, Snippert HJG. CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition. Oncotarget. 10: 1440-1457. PMID 30858928 DOI: 10.18632/Oncotarget.26677  0.337
2018 Bruurs LJM, van der Net MC, Zwakenberg S, Zwartkruis FJT, Bos JL. A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization. Plos One. 13: e0207159. PMID 30408122 DOI: 10.1371/Journal.Pone.0207159  0.363
2018 Bruurs LJM, van der Net MC, Zwakenberg S, Rosendahl Huber A, Post A, Zwartkruis FJ, Bos JL. The phosphatase PTPL1 is required for PTEN-mediated regulation of apical membrane size. Molecular and Cellular Biology. PMID 29581186 DOI: 10.1128/Mcb.00102-18  0.335
2018 Pannekoek WJ, Vliem MJ, Bos JL. Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions. Small Gtpases. 0. PMID 29388865 DOI: 10.1080/21541248.2018.1431512  0.365
2017 Bos JL. From Ras to Rap and Back, a Journey of 35 Years. Cold Spring Harbor Perspectives in Medicine. PMID 28778969 DOI: 10.1101/Cshperspect.A031468  0.387
2017 Bruurs LJ, Zwakenberg S, van der Net MC, Zwartkruis FJ, Bos JL. A two-tiered mechanism enables localized Cdc42 signaling during enterocyte polarization. Molecular and Cellular Biology. PMID 28069739 DOI: 10.1128/Mcb.00547-16  0.358
2016 Rehmann H, Bos JL. Ras Association-Domain Dimers Bring Proteins Together. Structure (London, England : 1993). 24: 2039-2040. PMID 27926831 DOI: 10.1016/J.Str.2016.11.010  0.38
2016 Verissimo CS, Overmeer RM, Ponsioen B, Drost J, Mertens S, Verlaan-Klink I, van Gerwen B, van der Ven M, Van de Wetering M, Egan DA, Bernards R, Clevers H, Bos JL, Snippert HJ. Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening. Elife. 5. PMID 27845624 DOI: 10.7554/Elife.18489  0.351
2015 Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL. ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. The Journal of Cell Biology. 210: 1055-63. PMID 26416959 DOI: 10.1083/Jcb.201505118  0.307
2015 Post A, Pannekoek WJ, Ponsioen B, Vliem MJ, Bos JL. Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation. Molecular and Cellular Biology. 35: 2495-502. PMID 25963656 DOI: 10.1128/Mcb.01453-14  0.399
2015 Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H. Structure-guided design of selective Epac1 and Epac2 agonists. Plos Biology. 13: e1002038. PMID 25603503 DOI: 10.1371/Journal.Pbio.1002038  0.33
2014 Bruurs LJ, Bos JL. Mechanisms of isoform specific Rap2 signaling during enterocytic brush border formation. Plos One. 9: e106687. PMID 25203140 DOI: 10.1371/Journal.Pone.0106687  0.363
2014 Consonni SV, Brouwer PM, van Slobbe ES, Bos JL. The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation. Plos One. 9: e98253. PMID 24858808 DOI: 10.1371/Journal.Pone.0098253  0.333
2014 Pannekoek WJ, Post A, Bos JL. Rap1 signaling in endothelial barrier control. Cell Adhesion & Migration. 8: 100-7. PMID 24714377 DOI: 10.4161/Cam.27352  0.376
2013 Magliozzi R, Low TY, Weijts BG, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJ, Bos JL, de Bruin A, Heck AJ, Guardavaccaro D. Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2. Developmental Cell. 27: 574-85. PMID 24290981 DOI: 10.1016/J.Devcel.2013.10.023  0.38
2013 Post A, Pannekoek WJ, Ross SH, Verlaan I, Brouwer PM, Bos JL. Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29. Proceedings of the National Academy of Sciences of the United States of America. 110: 11427-32. PMID 23798437 DOI: 10.1073/Pnas.1306595110  0.435
2013 Pannekoek WJ, Linnemann JR, Brouwer PM, Bos JL, Rehmann H. Rap1 and Rap2 antagonistically control endothelial barrier resistance. Plos One. 8: e57903. PMID 23469100 DOI: 10.1371/Journal.Pone.0057903  0.364
2013 Meijer LA, Zhou H, Chan OY, Altelaar AF, Hennrich ML, Mohammed S, Bos JL, Heck AJ. Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway. Molecular Biosystems. 9: 732-49. PMID 23403867 DOI: 10.1039/C3Mb25524G  0.396
2012 Ross SH, Spanjaard E, Post A, Vliem MJ, Kristyanto H, Bos JL, de Rooij J. Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation. Plos One. 7: e50072. PMID 23209645 DOI: 10.1371/Journal.Pone.0050072  0.406
2012 Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL. Rap2A links intestinal cell polarity to brush border formation. Nature Cell Biology. 14: 793-801. PMID 22797597 DOI: 10.1038/Ncb2537  0.372
2012 Bos JL, Pannekoek WJ. Semaphorin signaling meets rap. Science Signaling. 5: pe6. PMID 22355186 DOI: 10.1126/Scisignal.2002913  0.449
2012 Consonni SV, Gloerich M, Spanjaard E, Bos JL. cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane. Proceedings of the National Academy of Sciences of the United States of America. 109: 3814-9. PMID 22343288 DOI: 10.1073/Pnas.1117599109  0.353
2011 van Dam TJ, Zwartkruis FJ, Bos JL, Snel B. Evolution of the TOR pathway. Journal of Molecular Evolution. 73: 209-20. PMID 22057117 DOI: 10.1007/S00239-011-9469-9  0.343
2011 Pannekoek WJ, van Dijk JJ, Chan OY, Huveneers S, Linnemann JR, Spanjaard E, Brouwer PM, van der Meer AJ, Zwartkruis FJ, Rehmann H, de Rooij J, Bos JL. Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control. Cellular Signalling. 23: 2056-64. PMID 21840392 DOI: 10.1016/J.Cellsig.2011.07.022  0.394
2011 Gloerich M, Bos JL. Regulating Rap small G-proteins in time and space. Trends in Cell Biology. 21: 615-23. PMID 21820312 DOI: 10.1016/J.Tcb.2011.07.001  0.365
2011 van Dam TJ, Bos JL, Snel B. Evolution of the Ras-like small GTPases and their regulators. Small Gtpases. 2: 4-16. PMID 21686276 DOI: 10.4161/Sgtp.2.1.15113  0.417
2011 Gloerich M, Vliem MJ, Prummel E, Meijer LA, Rensen MG, Rehmann H, Bos JL. The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity. The Journal of Cell Biology. 193: 1009-20. PMID 21670213 DOI: 10.1083/Jcb.201011126  0.429
2011 Ross SH, Post A, Raaijmakers JH, Verlaan I, Gloerich M, Bos JL. Ezrin is required for efficient Rap1-induced cell spreading. Journal of Cell Science. 124: 1808-18. PMID 21540295 DOI: 10.1242/Jcs.079830  0.403
2011 Stokman G, Qin Y, Genieser HG, Schwede F, de Heer E, Bos JL, Bajema IM, van de Water B, Price LS. Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure. Journal of the American Society of Nephrology : Jasn. 22: 859-72. PMID 21493776 DOI: 10.1681/Asn.2010040423  0.334
2010 Gloerich M, Ponsioen B, Vliem MJ, Zhang Z, Zhao J, Kooistra MR, Price LS, Ritsma L, Zwartkruis FJ, Rehmann H, Jalink K, Bos JL. Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins. Molecular and Cellular Biology. 30: 5421-31. PMID 20855527 DOI: 10.1128/Mcb.00463-10  0.431
2010 Gloerich M, Bos JL. Epac: defining a new mechanism for cAMP action. Annual Review of Pharmacology and Toxicology. 50: 355-75. PMID 20055708 DOI: 10.1146/Annurev.Pharmtox.010909.105714  0.366
2009 Epping MT, Meijer LA, Bos JL, Bernards R. UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid. Molecular Cancer Research : McR. 7: 1861-70. PMID 19843631 DOI: 10.1158/1541-7786.Mcr-09-0187  0.325
2009 van Dam TJ, Rehmann H, Bos JL, Snel B. Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi. Cellular Signalling. 21: 1579-85. PMID 19567266 DOI: 10.1016/J.Cellsig.2009.06.004  0.403
2009 Hara S, Nakaseko C, Yamasaki S, Hattori M, Bos JL, Saito Y, Minato N, Saito T. Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal. Hematology (Amsterdam, Netherlands). 14: 150-8. PMID 19490760 DOI: 10.1179/102453309X402241  0.405
2009 Ponsioen B, Gloerich M, Ritsma L, Rehmann H, Bos JL, Jalink K. Direct spatial control of Epac1 by cyclic AMP. Molecular and Cellular Biology. 29: 2521-31. PMID 19273589 DOI: 10.1128/Mcb.01630-08  0.403
2009 Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL. Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors. Biochimica Et Biophysica Acta. 1788: 790-6. PMID 19159611 DOI: 10.1016/J.Bbamem.2008.12.010  0.429
2009 Raaijmakers JH, Bos JL. Specificity in Ras and Rap signaling. The Journal of Biological Chemistry. 284: 10995-9. PMID 19091745 DOI: 10.1074/Jbc.R800061200  0.432
2008 Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL. Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. Nature. 455: 124-7. PMID 18660803 DOI: 10.1038/Nature07187  0.392
2008 Lorenowicz MJ, Fernandez-Borja M, Kooistra MR, Bos JL, Hordijk PL. PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways. European Journal of Cell Biology. 87: 779-92. PMID 18635287 DOI: 10.1016/J.Ejcb.2008.05.004  0.344
2008 Dubé N, Kooistra MR, Pannekoek WJ, Vliem MJ, Oorschot V, Klumperman J, Rehmann H, Bos JL. The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions. Cellular Signalling. 20: 1608-15. PMID 18585005 DOI: 10.1016/J.Cellsig.2008.05.006  0.388
2008 Poppe H, Rybalkin SD, Rehmann H, Hinds TR, Tang XB, Christensen AE, Schwede F, Genieser HG, Bos JL, Doskeland SO, Beavo JA, Butt E. Cyclic nucleotide analogs as probes of signaling pathways. Nature Methods. 5: 277-8. PMID 18376388 DOI: 10.1038/Nmeth0408-277  0.309
2008 Lyle KS, Raaijmakers JH, Bruinsma W, Bos JL, de Rooij J. cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics. Cellular Signalling. 20: 1104-16. PMID 18346875 DOI: 10.1016/J.Cellsig.2008.01.018  0.382
2008 Harper SM, Wienk H, Wechselberger RW, Bos JL, Boelens R, Rehmann H. Structural dynamics in the activation of Epac. The Journal of Biological Chemistry. 283: 6501-8. PMID 18167352 DOI: 10.1074/Jbc.M707849200  0.36
2007 Frische EW, Pellis-van Berkel W, van Haaften G, Cuppen E, Plasterk RH, Tijsterman M, Bos JL, Zwartkruis FJ. RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans. The Embo Journal. 26: 5083-92. PMID 17989692 DOI: 10.1038/Sj.Emboj.7601922  0.416
2007 Bos JL, Rehmann H, Wittinghofer A. GEFs and GAPs: critical elements in the control of small G proteins. Cell. 129: 865-77. PMID 17540168 DOI: 10.1016/J.Cell.2007.05.018  0.378
2007 Raaijmakers JH, Deneubourg L, Rehmann H, de Koning J, Zhang Z, Krugmann S, Erneux C, Bos JL. The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner. Cellular Signalling. 19: 1249-57. PMID 17314030 DOI: 10.1016/J.Cellsig.2006.12.015  0.389
2007 Ster J, De Bock F, Guérineau NC, Janossy A, Barrère-Lemaire S, Bos JL, Bockaert J, Fagni L. Exchange protein activated by cAMP (Epac) mediates cAMP activation of p38 MAPK and modulation of Ca2+-dependent K+ channels in cerebellar neurons. Proceedings of the National Academy of Sciences of the United States of America. 104: 2519-24. PMID 17284589 DOI: 10.1073/Pnas.0611031104  0.374
2007 Rehmann H, Wittinghofer A, Bos JL. Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nature Reviews. Molecular Cell Biology. 8: 63-73. PMID 17183361 DOI: 10.1038/Nrm2082  0.379
2007 Kooistra MR, Dubé N, Bos JL. Rap1: a key regulator in cell-cell junction formation. Journal of Cell Science. 120: 17-22. PMID 17182900 DOI: 10.1242/Jcs.03306  0.415
2006 Bos JL. Epac proteins: multi-purpose cAMP targets. Trends in Biochemical Sciences. 31: 680-6. PMID 17084085 DOI: 10.1016/J.Tibs.2006.10.002  0.441
2006 Kang G, Chepurny OG, Malester B, Rindler MJ, Rehmann H, Bos JL, Schwede F, Coetzee WA, Holz GG. cAMP sensor Epac as a determinant of ATP-sensitive potassium channel activity in human pancreatic beta cells and rat INS-1 cells. The Journal of Physiology. 573: 595-609. PMID 16613879 DOI: 10.1113/Jphysiol.2006.107391  0.337
2006 Rehmann H, Das J, Knipscheer P, Wittinghofer A, Bos JL. Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature. 439: 625-8. PMID 16452984 DOI: 10.1038/Nature04468  0.405
2006 Roccio M, Bos JL, Zwartkruis FJ. Regulation of the small GTPase Rheb by amino acids. Oncogene. 25: 657-64. PMID 16170341 DOI: 10.1038/Sj.Onc.1209106  0.37
2005 Nobukuni T, Joaquin M, Roccio M, Dann SG, Kim SY, Gulati P, Byfield MP, Backer JM, Natt F, Bos JL, Zwartkruis FJ, Thomas G. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proceedings of the National Academy of Sciences of the United States of America. 102: 14238-43. PMID 16176982 DOI: 10.1073/Pnas.0506925102  0.355
2005 Kooistra MR, Corada M, Dejana E, Bos JL. Epac1 regulates integrity of endothelial cell junctions through VE-cadherin. Febs Letters. 579: 4966-72. PMID 16115630 DOI: 10.1016/J.Febslet.2005.07.080  0.395
2005 Zhang Z, Rehmann H, Price LS, Riedl J, Bos JL. AF6 negatively regulates Rap1-induced cell adhesion. The Journal of Biological Chemistry. 280: 33200-5. PMID 16051602 DOI: 10.1074/Jbc.M505057200  0.424
2005 Bos JL. Linking Rap to cell adhesion. Current Opinion in Cell Biology. 17: 123-8. PMID 15780587 DOI: 10.1016/J.Ceb.2005.02.009  0.358
2005 Riedl JA, Brandt DT, Batlle E, Price LS, Clevers H, Bos JL. Down-regulation of Rap1 activity is involved in ephrinB1-induced cell contraction. The Biochemical Journal. 389: 465-9. PMID 15725075 DOI: 10.1042/Bj20050048  0.441
2005 Kuiperij HB, van der Horst A, Raaijmakers J, Weijzen S, Medema RH, Bos JL, Burgering BM, Zwartkruis FJ. Activation of FoxO transcription factors contributes to the antiproliferative effect of cAMP. Oncogene. 24: 2087-95. PMID 15688004 DOI: 10.1038/Sj.Onc.1208450  0.607
2005 Pellis-van Berkel W, Verheijen MH, Cuppen E, Asahina M, de Rooij J, Jansen G, Plasterk RH, Bos JL, Zwartkruis FJ. Requirement of the Caenorhabditis elegans RapGEF pxf-1 and rap-1 for epithelial integrity. Molecular Biology of the Cell. 16: 106-16. PMID 15525675 DOI: 10.1091/Mbc.E04-06-0492  0.367
2004 Ponsioen B, Zhao J, Riedl J, Zwartkruis F, van der Krogt G, Zaccolo M, Moolenaar WH, Bos JL, Jalink K. Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. Embo Reports. 5: 1176-80. PMID 15550931 DOI: 10.1038/Sj.Embor.7400290  0.362
2004 Essers MA, Weijzen S, de Vries-Smits AM, Saarloos I, de Ruiter ND, Bos JL, Burgering BM. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. The Embo Journal. 23: 4802-12. PMID 15538382 DOI: 10.1038/Sj.Emboj.7600476  0.433
2004 Bos JL, Burgering BM. Molecular mechanisms in signal transduction and cancer. Embo Reports. 5: 855-9. PMID 15319778 DOI: 10.1038/Sj.Embor.7400220  0.303
2004 Enserink JM, Price LS, Methi T, Mahic M, Sonnenberg A, Bos JL, Taskén K. The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin. The Journal of Biological Chemistry. 279: 44889-96. PMID 15302884 DOI: 10.1074/Jbc.M404599200  0.414
2004 Remans PH, Gringhuis SI, van Laar JM, Sanders ME, Papendrecht-van der Voort EA, Zwartkruis FJ, Levarht EW, Rosas M, Coffer PJ, Breedveld FC, Bos JL, Tak PP, Verweij CL, Reedquist KA. Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. Journal of Immunology (Baltimore, Md. : 1950). 173: 920-31. PMID 15240679 DOI: 10.4049/Jimmunol.173.2.920  0.399
2004 Price LS, Hajdo-Milasinovic A, Zhao J, Zwartkruis FJ, Collard JG, Bos JL. Rap1 regulates E-cadherin-mediated cell-cell adhesion. The Journal of Biological Chemistry. 279: 35127-32. PMID 15166221 DOI: 10.1074/Jbc.M404917200  0.425
2004 Rehmann H, Bos JL. Signal transduction: thumbs up for inactivation. Nature. 429: 138-9. PMID 15141193 DOI: 10.1038/429138A  0.362
2004 van Triest M, Bos JL. Pull-down assays for guanoside 5'-triphosphate-bound Ras-like guanosine 5'-triphosphatases. Methods in Molecular Biology (Clifton, N.J.). 250: 97-102. PMID 14755082 DOI: 10.1385/1-59259-671-1:97  0.344
2004 Dansen TB, Kops GJ, Denis S, Jelluma N, Wanders RJ, Bos JL, Burgering BM, Wirtz KW. Regulation of sterol carrier protein gene expression by the forkhead transcription factor FOXO3a. Journal of Lipid Research. 45: 81-8. PMID 14563822 DOI: 10.1194/Jlr.M300111-Jlr200  0.328
2003 Bos JL. Epac: a new cAMP target and new avenues in cAMP research. Nature Reviews. Molecular Cell Biology. 4: 733-8. PMID 14506476 DOI: 10.1038/Nrm1197  0.366
2003 Rehmann H, Schwede F, Døskeland SO, Wittinghofer A, Bos JL. Ligand-mediated activation of the cAMP-responsive guanine nucleotide exchange factor Epac. The Journal of Biological Chemistry. 278: 38548-56. PMID 12888551 DOI: 10.1074/Jbc.M306292200  0.41
2003 Garami A, Zwartkruis FJ, Nobukuni T, Joaquin M, Roccio M, Stocker H, Kozma SC, Hafen E, Bos JL, Thomas G. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Molecular Cell. 11: 1457-66. PMID 12820960 DOI: 10.1016/S1097-2765(03)00220-X  0.399
2003 Christensen AE, Selheim F, de Rooij J, Dremier S, Schwede F, Dao KK, Martinez A, Maenhaut C, Bos JL, Genieser HG, Døskeland SO. cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. The Journal of Biological Chemistry. 278: 35394-402. PMID 12819211 DOI: 10.1074/Jbc.M302179200  0.387
2003 Rehmann H, Rueppel A, Bos JL, Wittinghofer A. Communication between the regulatory and the catalytic region of the cAMP-responsive guanine nucleotide exchange factor Epac. The Journal of Biological Chemistry. 278: 23508-14. PMID 12707263 DOI: 10.1074/Jbc.M301680200  0.37
2003 de Bruyn KM, Zwartkruis FJ, de Rooij J, Akkerman JW, Bos JL. The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes. The Journal of Biological Chemistry. 278: 22412-7. PMID 12690117 DOI: 10.1074/Jbc.M212036200  0.411
2003 Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ. Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. Biochimica Et Biophysica Acta. 1593: 141-9. PMID 12581858 DOI: 10.1016/S0167-4889(02)00365-8  0.396
2003 Rangarajan S, Enserink JM, Kuiperij HB, de Rooij J, Price LS, Schwede F, Bos JL. Cyclic AMP induces integrin-mediated cell adhesion through Epac and Rap1 upon stimulation of the beta 2-adrenergic receptor. The Journal of Cell Biology. 160: 487-93. PMID 12578910 DOI: 10.1083/Jcb.200209105  0.467
2003 Bos JL, de Bruyn K, Enserink J, Kuiperij B, Rangarajan S, Rehmann H, Riedl J, de Rooij J, van Mansfeld F, Zwartkruis F. The role of Rap1 in integrin-mediated cell adhesion. Biochemical Society Transactions. 31: 83-6. PMID 12546659 DOI: 10.1042/Bst0310083  0.515
2003 Rehmann H, Prakash B, Wolf E, Rueppel A, de Rooij J, Bos JL, Wittinghofer A. Structure and regulation of the cAMP-binding domains of Epac2. Nature Structural Biology. 10: 26-32. PMID 12469113 DOI: 10.1038/Nsb878  0.37
2002 Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Døskeland SO, Blank JL, Bos JL. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nature Cell Biology. 4: 901-6. PMID 12402047 DOI: 10.1038/Ncb874  0.47
2002 Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 419: 316-21. PMID 12239572 DOI: 10.1038/Nature01036  0.576
2002 de Bruyn KM, Rangarajan S, Reedquist KA, Figdor CG, Bos JL. The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion. The Journal of Biological Chemistry. 277: 29468-76. PMID 12171996 DOI: 10.1074/Jbc.M204990200  0.441
2002 Ouwens DM, de Ruiter ND, van der Zon GC, Carter AP, Schouten J, van der Burgt C, Kooistra K, Bos JL, Maassen JA, van Dam H. Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. The Embo Journal. 21: 3782-93. PMID 12110590 DOI: 10.1093/Emboj/Cdf361  0.442
2002 Remans P, Reedquist K, Bos J, Verweij C, Breedveld F, Laar Jv, Gringhuis S. Deregulated Ras and Rap1 signaling in rheumatoid arthritis T cells leads to persistent production of free radicals Arthritis Research & Therapy. 4: 52-52. DOI: 10.1186/Ar495  0.367
2002 Reedquist K, Remans P, Gringhuis S, Bruyn Kd, Rangarajan S, Bos J, Tak P. Constitutively activated N-Ras stimulates LFA-1-dependent adhesion in rheumatoid arthritis synovial fluid T lymphocytes Arthritis Research & Therapy. 4: 49-49. DOI: 10.1186/Ar491  0.409
2001 De Ruiter ND, Burgering BM, Bos JL. Regulation of the Forkhead transcription factor AFX by Ral-dependent phosphorylation of threonines 447 and 451. Molecular and Cellular Biology. 21: 8225-35. PMID 11689711 DOI: 10.1128/Mcb.21.23.8225-8235.2001  0.463
2001 Bos JL, de Rooij J, Reedquist KA. Rap1 signalling: adhering to new models. Nature Reviews. Molecular Cell Biology. 2: 369-77. PMID 11331911 DOI: 10.1038/35073073  0.447
2001 Bos JL. Signalling by the small GTPases Ras, Ral and Rap1 Biochemical Society Transactions. 29: A104-A104. DOI: 10.1042/Bst029A104C  0.377
2000 Amsen D, Kruisbeek A, Bos JL, Reedquist K. Activation of the Ras-related GTPase Rap1 by thymocyte TCR engagement and during selection. European Journal of Immunology. 30: 2832-41. PMID 11069064 DOI: 10.1002/1521-4141(200010)30:10<2832::Aid-Immu2832>3.0.Co;2-D  0.456
2000 de Ruiter ND, Wolthuis RM, van Dam H, Burgering BM, Bos JL. Ras-dependent regulation of c-Jun phosphorylation is mediated by the Ral guanine nucleotide exchange factor-Ral pathway. Molecular and Cellular Biology. 20: 8480-8. PMID 11046144 DOI: 10.1128/Mcb.20.22.8480-8488.2000  0.433
2000 Lu L, Annerén C, Reedquist KA, Bos JL, Welsh M. NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. Experimental Cell Research. 259: 370-7. PMID 10964504 DOI: 10.1006/Excr.2000.4984  0.403
2000 de Bruyn KM, de Rooij J, Wolthuis RM, Rehmann H, Wesenbeek J, Cool RH, Wittinghofer AH, Bos JL. RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral. The Journal of Biological Chemistry. 275: 29761-6. PMID 10889189 DOI: 10.1074/Jbc.M001160200  0.367
2000 Hackeng CM, Franke B, Relou IA, Gorter G, Bos JL, van Rijn HJ, Akkerman JW. Low-density lipoprotein activates the small GTPases Rap1 and Ral in human platelets. The Biochemical Journal. 349: 231-8. PMID 10861233 DOI: 10.1042/0264-6021:3490231  0.405
2000 Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature. 404: 782-7. PMID 10783894 DOI: 10.1038/35008115  0.609
2000 de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. The Journal of Biological Chemistry. 275: 20829-36. PMID 10777494 DOI: 10.1074/Jbc.M001113200  0.353
2000 Reedquist KA, Ross E, Koop EA, Wolthuis RM, Zwartkruis FJ, van Kooyk Y, Salmon M, Buckley CD, Bos JL. The small GTPase, Rap1, mediates CD31-induced integrin adhesion. The Journal of Cell Biology. 148: 1151-8. PMID 10725328 DOI: 10.1083/Jcb.148.6.1151  0.42
2000 Franke B, van Triest M, de Bruijn KM, van Willigen G, Nieuwenhuis HK, Negrier C, Akkerman JW, Bos JL. Sequential regulation of the small GTPase Rap1 in human platelets. Molecular and Cellular Biology. 20: 779-85. PMID 10629034 DOI: 10.1128/Mcb.20.3.779-785.2000  0.351
2000 Dremier S, Vandeput F, Zwartkruis FJ, Bos JL, Dumont JE, Maenhaut C. Activation of the small G protein Rap1 in dog thyroid cells by both cAMP-dependent and -independent pathways. Biochemical and Biophysical Research Communications. 267: 7-11. PMID 10623565 DOI: 10.1006/Bbrc.1999.1919  0.437
1999 de Rooij J, Boenink NM, van Triest M, Cool RH, Wittinghofer A, Bos JL. PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2. The Journal of Biological Chemistry. 274: 38125-30. PMID 10608883 DOI: 10.1074/Jbc.274.53.38125  0.391
1999 Zwartkruis FJ, Bos JL. Ras and Rap1: two highly related small GTPases with distinct function. Experimental Cell Research. 253: 157-65. PMID 10579920 DOI: 10.1006/Excr.1999.4695  0.441
1999 Spaargaren M, Bos JL. Rab5 induces Rac-independent lamellipodia formation and cell migration. Molecular Biology of the Cell. 10: 3239-50. PMID 10512863 DOI: 10.1091/Mbc.10.10.3239  0.436
1999 Bos JL, Zwartkruls FJT. Rhapsody in G proteins Nature. 400: 820-821. PMID 10476955 DOI: 10.1038/23594  0.327
1999 Verheijen MH, Wolthuis RM, Defize LH, den Hertog J, Bos JL. Interdependent action of RalGEF and Erk in Ras-induced primitive endoderm differentiation of F9 embryonal carcinoma cells. Oncogene. 18: 4435-9. PMID 10442634 DOI: 10.1038/Sj.Onc.1202834  0.432
1999 M'Rabet L, Coffer PJ, Wolthuis RMF, Zwartkruis F, Koenderman L, Bos JL. Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils Journal of Biological Chemistry. 274: 21847-21852. PMID 10419502 DOI: 10.1074/Jbc.274.31.21847  0.46
1999 Tsukamoto N, Hattori M, Yang H, Bos JL, Minato N. Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion Journal of Biological Chemistry. 274: 18463-18469. PMID 10373454 DOI: 10.1074/Jbc.274.26.18463  0.429
1999 Steegenga WT, Shvarts A, Riteco N, Bos JL, Jochemsen AG. Distinct regulation of p53 and p73 activity by adenovirus E1A, E1B, and E4orf6 proteins Molecular and Cellular Biology. 19: 3885-3894. PMID 10207112 DOI: 10.1128/Mcb.19.5.3885  0.305
1999 Nancy V, Wolthuis RMF, De Tand MF, Janoueix-Lerosey I, Bos JL, De Gunzburgt J. Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 Journal of Biological Chemistry. 274: 8737-8745. PMID 10085114 DOI: 10.1074/Jbc.274.13.8737  0.46
1999 Wolthuis RM, Bos JL. Ras caught in another affair: The exchange factors for Ral Current Opinion in Genetics and Development. 9: 112-117. PMID 10072355 DOI: 10.1016/S0959-437X(99)80016-1  0.428
1999 Verheijen MHG, Wolthuis RMF, Bos JL, Defize LHK. The Ras/Erk pathway induces primitive endoderm but prevents parietal endoderm differentiation of F9 embryonal carcinoma cells Journal of Biological Chemistry. 274: 1487-1494. PMID 9880524 DOI: 10.1074/Jbc.274.3.1487  0.417
1998 van Weering DH, Bos JL. Signal transduction by the receptor tyrosine kinase Ret Recent Results in Cancer Research. Fortschritte Der Krebsforschung. ProgrèS Dans Les Recherches Sur Le Cancer. 154: 271-281. PMID 10027007 DOI: 10.1007/978-3-642-46870-4_18  0.414
1998 De Rooij J, Zwartkruis FJT, Verheijen MHG, Cool RH, Nijman SMB, Wittinghofer A, Bos JL. Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP Nature. 396: 474-477. PMID 9853756 DOI: 10.1038/24884  0.499
1998 Bos JL. All in the family? New insights and questions regarding interconnectivity of Ras, Rap1 and Ral Embo Journal. 17: 6776-6782. PMID 9843482 DOI: 10.1093/Emboj/17.23.6776  0.398
1998 McLeod SJ, Ingham RJ, Bos JL, Kurosaki T, Gold MR. Activation of the Rap1 GTPase by the B cell antigen receptor Journal of Biological Chemistry. 273: 29218-29223. PMID 9786933 DOI: 10.1074/jbc.273.44.29218  0.367
1998 Zwartkruis FJT, Wolthuis RMF, Nabben NMJM, Franke B, Bos JL. Extracellular signal-regulated activation of Rap1 fails to interfere in Ras effector signalling Embo Journal. 17: 5905-5912. PMID 9774335 DOI: 10.1093/Emboj/17.20.5905  0.474
1998 M'Rabet L, Coffer P, Zwartkruis F, Franke B, Segal AW, Koenderman L, Bos JL. Activation of the small GTPase Rap1 in human neutrophils Blood. 92: 2133-2140. PMID 9731072 DOI: 10.1182/Blood.V92.6.2133.418K19_2133_2140  0.375
1998 Aarts LH, Schrama LH, Hage WJ, Bos JL, Gispen WH, Schotman P. B-50/GAP-43-induced formation of filopodia depends on Rho-GTPase. Molecular Biology of the Cell. 9: 1279-92. PMID 9614174 DOI: 10.1091/Mbc.9.6.1279  0.318
1998 Wolthuis RMF, Franke B, Van Triest M, Bauer B, Cool RH, Camonis JH, Akkerman JWN, Bos JL. Activation of the small GTPase Ral in platelets Molecular and Cellular Biology. 18: 2486-2491. PMID 9566869 DOI: 10.1128/Mcb.18.5.2486  0.383
1998 Wolthuis RMF, Zwartkruis F, Moen TC, Bos JL. Ras-dependent activation of the small GTPase Ral Current Biology. 8: 471-474. PMID 9550702 DOI: 10.1016/S0960-9822(98)70183-6  0.438
1998 Van Weering DHJ, De Rooij J, Marte B, Downward J, Bos JL, Burgering BMT. Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras Molecular and Cellular Biology. 18: 1802-1811. PMID 9528752 DOI: 10.1128/Mcb.18.4.1802  0.464
1998 Reedquist KA, Bos JL. Costimulation through CD28 suppresses T cell receptor-dependent activation of the Ras-like small GTPase Rap1 in human T lymphocytes Journal of Biological Chemistry. 273: 4944-4949. PMID 9478939 DOI: 10.1074/Jbc.273.9.4944  0.401
1997 Coffer PJ, Van Puijenbroek A, Burgering BMT, Klop-de Jonge M, Koenderman L, Bos JL, Kruijer W. Insulin activates stat3 independently of p21ras-ERK and PI-3K signal transduction Oncogene. 15: 2529-2539. PMID 9399641 DOI: 10.1038/Sj.Onc.1201429  0.405
1997 Bos JL. Ras-like GTpases Biochimica Et Biophysica Acta - Reviews On Cancer. 1333: M19-M31. PMID 9395281 DOI: 10.1016/S0304-419X(97)00015-2  0.345
1997 Wolthuis RMF, De Ruiter ND, Cool RH, Bos JL. Stimulation of gene induction and cell growth by the Ras effector Rlf Embo Journal. 16: 6748-6761. PMID 9362489 DOI: 10.1093/Emboj/16.22.6748  0.465
1997 Bos JL, Franke B, M'Rabet L, Reedquist K, Zwartkruis F. In search of a function for the Ras-like GTPase Rap1 Febs Letters. 410: 59-62. PMID 9247123 DOI: 10.1016/S0014-5793(97)00324-4  0.395
1997 van Puijenbroek AA, van Weering DH, van den Brink CE, Bos JL, van der Saag PT, de Laat SW, den Hertog J. Cell scattering of SK-N-MC neuroepithelioma cells in response to Ret and FGF receptor tyrosine kinase activation is correlated with sustained ERK2 activation. Oncogene. 14: 1147-57. PMID 9121763 DOI: 10.1038/Sj.Onc.1200911  0.407
1997 De Rooij J, Bos JL. Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras Oncogene. 14: 623-625. PMID 9053862 DOI: 10.1038/Sj.Onc.1201005  0.414
1997 Franke B, Akkerman JWN, Bos JL. Rapid Ca2+-mediated activation of Rap1 in human platelets Embo Journal. 16: 252-259. PMID 9029146 DOI: 10.1093/Emboj/16.2.252  0.346
1997 Van Weering DHJ, Bos JL. Glial cell line-derived neurotrophic factor induces Ret-mediated lamellipodia formation Journal of Biological Chemistry. 272: 249-254. PMID 8995255 DOI: 10.1074/Jbc.272.1.249  0.442
1996 Dorrestijn J, Ouwens DM, Van Den Berghe N, Bos JL, Maassen JA. Expression of a dominant-negative Ras mutant does not affect stimulation of glucose uptake and glycogen synthesis by insulin Diabetologia. 39: 558-563. PMID 8739915 DOI: 10.1007/Bf00403302  0.377
1996 Peppelenbosch MP, Tertoolen LG, de Vries-Smits AM, Qiu RG, M'Rabet L, Symons MH, de Laat SW, Bos JL. Rac-dependent and -independent pathways mediate growth factor-induced Ca2+ influx. The Journal of Biological Chemistry. 271: 7883-6. PMID 8626463 DOI: 10.1074/Jbc.271.14.7883  0.334
1995 Burgering BM, Bos JL. Regulation of Ras-mediated signalling: more than one way to skin a cat. Trends in Biochemical Sciences. 20: 18-22. PMID 7878738 DOI: 10.1016/S0968-0004(00)88944-6  0.442
1995 Pronk GJ, Bos JL. The role of p21ras in receptor tyrosine kinase signalling. Biochimica Et Biophysica Acta. 1198: 131-47. PMID 7819271 DOI: 10.1016/0304-419X(94)90010-8  0.414
1995 Peppelenbosch MP, Qiu RG, de Vries-Smits AM, Tertoolen LG, de Laat SW, McCormick F, Hall A, Symons MH, Bos JL. Rac mediates growth factor-induced arachidonic acid release. Cell. 81: 849-56. PMID 7781062 DOI: 10.1016/0092-8674(95)90005-5  0.334
1994 Burgering BM, de Vries-Smits AM, Medema RH, van Weeren PC, Tertoolen LG, Bos JL. Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways. Molecular and Cellular Biology. 13: 7248-56. PMID 8246947 DOI: 10.1128/Mcb.13.12.7248  0.611
1994 Burgering BM, Pronk GJ, Medema JP, van der Voorn L, de Vries Smits AM, van Weeren PC, Bos JL. Role of p21ras in growth factor signal transduction. Biochemical Society Transactions. 21: 888-94. PMID 8132088 DOI: 10.1042/Bst0210888  0.309
1994 Pronk GJ, de Vries-Smits AM, Buday L, Downward J, Maassen JA, Medema RH, Bos JL. Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras. Molecular and Cellular Biology. 14: 1575-81. PMID 8114695 DOI: 10.1128/Mcb.14.3.1575  0.555
1994 Ming XF, Burgering BM, Wennström S, Claesson-Welsh L, Heldin CH, Bos JL, Kozma SC, Thomas G. Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature. 371: 426-9. PMID 8090223 DOI: 10.1038/371426A0  0.449
1994 Medema JP, Sark MW, Backendorf C, Bos JL. Calcium inhibits epidermal growth factor-induced activation of p21ras in human primary keratinocytes. Molecular and Cellular Biology. 14: 7078-85. PMID 7935423 DOI: 10.1128/Mcb.14.11.7078  0.335
1993 Osterop AP, Medema RH, vd Zon GC, Bos JL, Möller W, Maassen JA. Epidermal-growth-factor receptors generate Ras.GTP more efficiently than insulin receptors. European Journal of Biochemistry. 212: 477-82. PMID 8444185 DOI: 10.1111/J.1432-1033.1993.Tb17684.X  0.602
1993 Medema RH, de Vries-Smits AM, van der Zon GC, Maassen JA, Bos JL. Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Molecular and Cellular Biology. 13: 155-62. PMID 8417322 DOI: 10.1128/Mcb.13.1.155  0.595
1993 van Corven EJ, Hordijk PL, Medema RH, Bos JL, Moolenaar WH. Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 90: 1257-61. PMID 7679495 DOI: 10.1073/Pnas.90.4.1257  0.605
1993 Burgering BMT, Pronk GJ, Weeren PCV, Chardin P, Bos JL. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. The Embo Journal. 12: 4211-4220. DOI: 10.1002/J.1460-2075.1993.Tb06105.X  0.428
1992 de Vries-Smits AM, Burgering BM, Leevers SJ, Marshall CJ, Bos JL. Involvement of p21ras in activation of extracellular signal-regulated kinase 2. Nature. 357: 602-4. PMID 1608472 DOI: 10.1038/357602A0  0.476
1992 Maassen JA, Burgering BM, Medema RH, Osterop AP, van der Zon GC, Möller W, Bos JL. The role of ras proteins in insulin signal transduction. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. 24: 214-8. PMID 1398459 DOI: 10.1055/s-2007-1003296  0.568
1992 Medema RH, de Laat WL, Martin GA, McCormick F, Bos JL. GTPase-activating protein SH2-SH3 domains induce gene expression in a Ras-dependent fashion. Molecular and Cellular Biology. 12: 3425-30. PMID 1321335 DOI: 10.1128/Mcb.12.8.3425  0.623
1991 Medema RH, Wubbolts R, Bos JL. Two dominant inhibitory mutants of p21ras interfere with insulin-induced gene expression. Molecular and Cellular Biology. 11: 5963-7. PMID 1658621 DOI: 10.1128/Mcb.11.12.5963  0.584
1986 Verlaan-de Vries M, Bogaard ME, van den Elst H, van Boom JH, van der Eb AJ, Bos JL. A dot-blot screening procedure for mutated ras oncogenes using synthetic oligodeoxynucleotides Gene. 50: 313-320. PMID 3582981 DOI: 10.1016/0378-1119(86)90335-5  0.301
1983 Sloof P, Bos JL, Konings AF, Menke HH, Borst P, Gutteridge WE, Leon W. Characterization of satellite DNA in Trypanosoma brucei and Trypanosoma cruzi. Journal of Molecular Biology. 167: 1-21. PMID 6345792 DOI: 10.1016/S0022-2836(83)80031-X  0.423
1980 Bos JL, Heyting C, Van der Horst G, Borst P. The organization of repeating units in mitochondrial DNA from yeast petite mutants. Current Genetics. 1: 233-9. PMID 24189664 DOI: 10.1007/Bf00390949  0.353
1980 Bos JL, Osinga KA, Van der Horst G, Hecht NB, Tabak HF, Van Ommen GJ, Borst P. Splice point sequence and transcripts of the intervening sequence in the mitochondrial 21S ribosomal RNA gene of yeast. Cell. 20: 207-14. PMID 6993009 DOI: 10.1016/0092-8674(80)90248-2  0.357
1979 Bos JL, Osinga KA, Van der Horst G, Borst P. Nucleotide sequence of the mitochondrial structural genes for cysteine-tRNA and histidine-tRNA of yeast. Nucleic Acids Research. 6: 3255-66. PMID 384365 DOI: 10.1093/Nar/6.10.3255  0.355
1979 Heyting C, Meijlink FC, Verbeet MP, Sanders JP, Bos JL, Borst P. Fine structure of the 21S ribosomal RNA region on yeast mitochondria DNA. I. Construction of the physical map and localization of the cistron for the 21S mitochondrial ribosomal RNA. Molecular & General Genetics : Mgg. 168: 231-46. PMID 374986 DOI: 10.1007/Bf00271496  0.342
1979 Hensgens LA, Grivell LA, Borst P, Bos JL. Nucleotide sequence of the mitochondrial structural gene for subunit 9 of yeast ATPase complex. Proceedings of the National Academy of Sciences of the United States of America. 76: 1663-7. PMID 156363 DOI: 10.1073/Pnas.76.4.1663  0.455
1978 Bos JL, Van Kreijl CF, Ploegaert FH, Mol JN, Borst P. A conserved and unique (AT)-rich segment in yeast mitochondrial DNA. Nucleic Acids Research. 5: 4563-78. PMID 370773 DOI: 10.1093/Nar/5.12.4563  0.361
1978 Bos JL, Heyting C, Borst P, Arnberg AC, Van Bruggen EF. An insert in the single gene for the large ribosomal RNA in yeast mitochondrial DNA. Nature. 275: 336-8. PMID 357991 DOI: 10.1038/275336A0  0.351
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