Kenneth Kaushansky - Publications

Affiliations: 
University of Washington, Seattle, Seattle, WA 
Area:
Biochemistry, Cell Biology

185 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Kaushansky K. Thrombopoietin and its receptor in normal and neoplastic hematopoiesis Thrombosis Journal. 14. DOI: 10.1186/s12959-016-0095-z  1
2015 Kaushansky K. Thrombopoiesis. Seminars in Hematology. 52: 4-11. PMID 25578413 DOI: 10.1053/j.seminhematol.2014.10.003  1
2015 Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC, Bennett JM, Benz EJ, Berliner N, Bertino J, Bhatia R, ... ... Kaushansky K, et al. In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs Mayo Clinic Proceedings. DOI: 10.1016/j.mayocp.2015.06.001  1
2014 Kaushansky A, Kaushansky K. Systems biology of megakaryocytes. Advances in Experimental Medicine and Biology. 844: 59-84. PMID 25480637 DOI: 10.1007/978-1-4939-2095-2_4  1
2014 Sangkhae V, Etheridge SL, Kaushansky K, Hitchcock IS. The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm. Blood. 124: 3956-63. PMID 25339357 DOI: 10.1182/blood-2014-07-587238  1
2014 Carethers JM, Coughlin S, Diamond B, Erzurum S, Fried LP, Jameson JL, Kaushansky K, Klotman ME, Lemon S, Mitchell B, Rothman P, Sawyers C, Seidman C, Somlo S. The imperative to invest in science has never been greater. The Journal of Clinical Investigation. 124: 3680-1. PMID 25180532 DOI: 10.1172/JCI77894  1
2014 Sangkhae V, Saur SJ, Kaushansky A, Kaushansky K, Hitchcock IS. Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling. Experimental Hematology. 42: 477-86.e4. PMID 24607955 DOI: 10.1016/j.exphem.2014.02.007  1
2014 Hitchcock IS, Kaushansky K. Thrombopoietin from beginning to end. British Journal of Haematology. 165: 259-68. PMID 24499199 DOI: 10.1111/bjh.12772  1
2014 Etheridge SL, Roh ME, Cosgrove ME, Sangkhae V, Fox NE, Chen J, López JA, Kaushansky K, Hitchcock IS. JAK2V617F-positive endothelial cells contribute to clotting abnormalities in myeloproliferative neoplasms. Proceedings of the National Academy of Sciences of the United States of America. 111: 2295-300. PMID 24469804 DOI: 10.1073/pnas.1312148111  1
2011 Wang YV, Leblanc M, Fox N, Mao JH, Tinkum KL, Krummel K, Engle D, Piwnica-Worms D, Piwnica-Worms H, Balmain A, Kaushansky K, Wahl GM. Fine-tuning p53 activity through C-terminal modification significantly contributes to HSC homeostasis and mouse radiosensitivity. Genes & Development. 25: 1426-38. PMID 21724834 DOI: 10.1101/gad.2024411  1
2011 Jung AS, Kaushansky A, Macbeath G, Kaushansky K. Tensin2 is a novel mediator in thrombopoietin (TPO)-induced cellular proliferation by promoting Akt signaling. Cell Cycle (Georgetown, Tex.). 10: 1838-44. PMID 21527831 DOI: 10.4161/cc.10.11.15776  1
2011 Kaushansky K. Hematopoiesis and Hematopoietic Growth Factors Goldman's Cecil Medicine: Twenty Fourth Edition. 1: 1022-1024. DOI: 10.1016/B978-1-4377-1604-7.00159-7  1
2010 Saur SJ, Sangkhae V, Geddis AE, Kaushansky K, Hitchcock IS. Ubiquitination and degradation of the thrombopoietin receptor c-Mpl. Blood. 115: 1254-63. PMID 19880496 DOI: 10.1182/blood-2009-06-227033  1
2009 Kaushansky K. Determinants of platelet number and regulation of thrombopoiesis. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 147-52. PMID 20008193 DOI: 10.1182/asheducation-2009.1.147  1
2009 Kaushansky K, Ranney HM. Thrombopoietin in normal and neoplastic stem cell development. Best Practice & Research. Clinical Haematology. 22: 495-9. PMID 19959099 DOI: 10.1016/j.beha.2009.08.004  1
2009 Kaushansky K. Molecular mechanisms of thrombopoietin signaling Journal of Thrombosis and Haemostasis. 7: 235-238. PMID 19630807 DOI: 10.1111/j.1538-7836.2009.03419.x  1
2008 Barroga CF, Pham H, Kaushansky K. Thrombopoietin regulates c-Myb expression by modulating micro RNA 150 expression. Experimental Hematology. 36: 1585-92. PMID 18814950 DOI: 10.1016/j.exphem.2008.07.001  1
2008 Soda M, Willert K, Kaushansky K, Geddis AE. Inhibition of GSK-3beta promotes survival and proliferation of megakaryocytic cells through a beta-catenin-independent pathway. Cellular Signalling. 20: 2317-23. PMID 18804163 DOI: 10.1016/j.cellsig.2008.09.001  1
2008 Hitchcock IS, Chen MM, King JR, Kaushansky K. YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation. Blood. 112: 2222-31. PMID 18487512 DOI: 10.1182/blood-2008-01-134049  1
2008 Yoshida K, Kirito K, Yongzhen H, Ozawa K, Kaushansky K, Komatsu N. Thrombopoietin (TPO) regulates HIF-1alpha levels through generation of mitochondrial reactive oxygen species. International Journal of Hematology. 88: 43-51. PMID 18473128 DOI: 10.1007/s12185-008-0091-6  1
2008 Kaushansky K. Cell expansion and maintenance of stemness. Blood. 111: 3920-1. PMID 18434969 DOI: 10.1182/blood-2008-01-134619  1
2008 McIntosh B, Kaushansky K. Transcriptional regulation of bone marrow thrombopoietin by platelet proteins. Experimental Hematology. 36: 799-806. PMID 18410987 DOI: 10.1016/j.exphem.2008.02.012  1
2008 Geron I, Abrahamsson AE, Barroga CF, Kavalerchik E, Gotlib J, Hood JD, Durocher J, Mak CC, Noronha G, Soll RM, Tefferi A, Kaushansky K, Jamieson CH. Selective inhibition of JAK2-driven erythroid differentiation of polycythemia vera progenitors. Cancer Cell. 13: 321-30. PMID 18394555 DOI: 10.1016/j.ccr.2008.02.017  1
2008 Nakao T, Geddis AE, Fox NE, Kaushansky K. PI3K/Akt/FOXO3a pathway contributes to thrombopoietin-induced proliferation of primary megakaryocytes in vitro and in vivo via modulation of p27(Kip1). Cell Cycle (Georgetown, Tex.). 7: 257-66. PMID 18256550 DOI: 10.4161/cc.7.2.5148  1
2008 Kaushansky K. Historical review: megakaryopoiesis and thrombopoiesis. Blood. 111: 981-6. PMID 18223171 DOI: 10.1182/blood-2007-05-088500  1
2008 Kirito K, Sakoe K, Shinoda D, Takiyama Y, Kaushansky K, Komatsu N. A novel RUNX1 mutation in familial platelet disorder with propensity to develop myeloid malignancies. Haematologica. 93: 155-6. PMID 18166807 DOI: 10.3324/haematol.12050  1
2008 Jaffé ER, Kaushansky K. The American Society of Hematology: a success at age 50. Blood. 111: 11-5. PMID 18156500 DOI: 10.1182/blood-2007-09-112326  1
2008 Hitchcock IS, Fox NE, Prévost N, Sear K, Shattil SJ, Kaushansky K. Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage specific FAK knockout. Blood. 111: 596-604. PMID 17925492 DOI: 10.1182/blood-2007-05-089680  1
2008 Geron I, Abrahamsson AE, Barroga CF, Kavalerchik E, Gotlib J, Hood JD, Durocher J, Mak CC, Noronha G, Soll RM, Tefferi A, Kaushansky K, Jamieson CHM. Selective Inhibition of JAK2-Driven Erythroid Differentiation of Polycythemia Vera Progenitors (DOI:10.1016/j.ccr.2008.02.017) Cancer Cell. 13: 464. DOI: 10.1016/j.ccr.2008.04.004  1
2007 Geddis AE, Kaushansky K. Immunology. The root of platelet production. Science (New York, N.Y.). 317: 1689-91. PMID 17885117 DOI: 10.1126/science.1148946  1
2007 Hitchcock IS, Kaushansky K. Thrombopoietin promotes beta1-integrin-mediated adhesion in hematopoietic cells via the small GTPase Rapl. Experimental Hematology. 35: 793-801. PMID 17577928 DOI: 10.1016/j.exphem.2007.02.005  1
2007 Kaushansky K. The chronic myeloproliferative disorders and mutation of JAK2: Dameshek's 54 year old speculation comes of age. Best Practice & Research. Clinical Haematology. 20: 5-12. PMID 17336249 DOI: 10.1016/j.beha.2006.11.005  1
2007 Geddis AE, Fox NE, Tkachenko E, Kaushansky K. Endomitotic megakaryocytes that form a bipolar spindle exhibit cleavage furrow ingression followed by furrow regression. Cell Cycle (Georgetown, Tex.). 6: 455-60. PMID 17312391 DOI: 10.4161/cc.6.4.3836  1
2007 Kaushansky K, Shattil SJ. Bloodlines: the importance of mentoring for the future of hematology. Blood. 109: 1353-4. PMID 17047145 DOI: 10.1182/blood-2006-09-049908  1
2006 Kaushansky K. Hematopoietic growth factors, signaling and the chronic myeloproliferative disorders. Cytokine & Growth Factor Reviews. 17: 423-30. PMID 17055768 DOI: 10.1016/j.cytogfr.2006.09.005  1
2006 Kaushansky K. Lineage-specific hematopoietic growth factors. The New England Journal of Medicine. 354: 2034-45. PMID 16687716 DOI: 10.1056/NEJMra052706  1
2006 Coleman TR, Westenfelder C, Tögel FE, Yang Y, Hu Z, Swenson L, Leuvenink HG, Ploeg RJ, d'Uscio LV, Katusic ZS, Ghezzi P, Zanetti A, Kaushansky K, Fox NE, Cerami A, et al. Cytoprotective doses of erythropoietin or carbamylated erythropoietin have markedly different procoagulant and vasoactive activities. Proceedings of the National Academy of Sciences of the United States of America. 103: 5965-70. PMID 16585502 DOI: 10.1073/pnas.0601377103  1
2006 Kirito K, Kaushansky K. Transcriptional regulation of megakaryopoiesis: thrombopoietin signaling and nuclear factors. Current Opinion in Hematology. 13: 151-6. PMID 16567958 DOI: 10.1097/01.moh.0000219660.03657.4b  1
2006 Geddis AE, Kaushansky K. Endomitotic megakaryocytes form a midzone in anaphase but have a deficiency in cleavage furrow formation. Cell Cycle (Georgetown, Tex.). 5: 538-45. PMID 16552179 DOI: 10.4161/cc.5.5.2537  1
2006 Féral CC, Rose DM, Han J, Fox N, Silverman GJ, Kaushansky K, Ginsberg MH. Blocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory site. The Journal of Clinical Investigation. 116: 715-23. PMID 16470243 DOI: 10.1172/JCI26091  1
2006 Geddis AE, Fox NE, Kaushansky K. The Mpl receptor expressed on endothelial cells does not contribute significantly to the regulation of circulating thrombopoietin levels. Experimental Hematology. 34: 82-6. PMID 16413394 DOI: 10.1016/j.exphem.2005.09.008  1
2006 Chanprasert S, Geddis AE, Barroga C, Fox NE, Kaushansky K. Thrombopoietin (TPO) induces c-myc expression through a PI3K- and MAPK-dependent pathway that is not mediated by Akt, PKCzeta or mTOR in TPO-dependent cell lines and primary megakaryocytes. Cellular Signalling. 18: 1212-8. PMID 16380230 DOI: 10.1016/j.cellsig.2005.09.010  1
2006 Kaushansky K. The author replies [13] New England Journal of Medicine. 355: 527. DOI: 10.1056/NEJMc061171  1
2005 Kaushansky K. The molecular mechanisms that control thrombopoiesis. The Journal of Clinical Investigation. 115: 3339-47. PMID 16322778 DOI: 10.1172/JCI26674  1
2005 Kirito K, Kaushansky K. Thrombopoietin stimulates vascular endothelial cell growth factor (VEGF) production in hematopoietic stem cells. Cell Cycle (Georgetown, Tex.). 4: 1729-31. PMID 16258288 DOI: 10.4161/cc.4.12.2197  1
2005 Kaushansky K. Thrombopoietin and the hematopoietic stem cell. Annals of the New York Academy of Sciences. 1044: 139-41. PMID 15958707 DOI: 10.1196/annals.1349.018  1
2005 Kaushansky K. On the molecular origins of the chronic myeloproliferative disorders: it all makes sense. Blood. 105: 4187-90. PMID 15817681 DOI: 10.1182/blood-2005-03-1287  1
2005 Kirito K, Fox N, Komatsu N, Kaushansky K. Thrombopoietin enhances expression of vascular endothelial growth factor (VEGF) in primitive hematopoietic cells through induction of HIF-1alpha. Blood. 105: 4258-63. PMID 15705785 DOI: 10.1182/blood-2004-07-2712  1
2005 Fox NE, Kaushansky K. Engagement of integrin alpha4beta1 enhances thrombopoietin-induced megakaryopoiesis. Experimental Hematology. 33: 94-9. PMID 15661402 DOI: 10.1016/j.exphem.2004.10.002  1
2004 Kaushansky K. ASCI Presidential Address: Mentoring and teaching clinical investigation. The Journal of Clinical Investigation. 114: 1165-8. PMID 15489964 DOI: 10.1172/JCI23462  1
2004 Kirito K, Fox N, Kaushansky K. Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells. Molecular and Cellular Biology. 24: 6751-62. PMID 15254242 DOI: 10.1128/MCB.24.15.6751-6762.2004  1
2004 Geddis AE, Kaushansky K. Megakaryocytes express functional Aurora-B kinase in endomitosis. Blood. 104: 1017-24. PMID 15130946 DOI: 10.1182/blood-2004-02-0419  1
2004 Hankins J, Naidu P, Rieman M, Wang W, Kaushansky K, Rodriguez-Galindo C. Thrombocytosis in an infant with high thrombopoietin concentrations. Journal of Pediatric Hematology/Oncology. 26: 142-5. PMID 14767209 DOI: 10.1097/00043426-200402000-00019  1
2004 Geddis AE, Kaushansky K. Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production. Current Opinion in Pediatrics. 16: 15-22. PMID 14758109 DOI: 10.1097/00008480-200402000-00005  1
2003 Kaushansky K. Physician-scientists: preparation, opportunities, and national need. Experimental Biology and Medicine (Maywood, N.J.). 228: 1258-60. PMID 14681539  1
2003 Habib T, Nelson A, Kaushansky K. IL-21: a novel IL-2-family lymphokine that modulates B, T, and natural killer cell responses. The Journal of Allergy and Clinical Immunology. 112: 1033-45. PMID 14657853 DOI: 10.1016/j.jaci.2003.08.039  1
2003 Geddis AE, Kaushansky K. Cross-reactivity between erythropoietin and thrombopoietin at the level of Mpl does not account for the thrombocytosis seen in iron deficiency. Journal of Pediatric Hematology/Oncology. 25: 919-20; author reply. PMID 14608207  1
2003 Kaushansky K. Thrombopoietin: A tool for understanding thrombopoiesis Journal of Thrombosis and Haemostasis. 1: 1587-1592. PMID 12871295 DOI: 10.1046/j.1538-7836.2003.00273.x  1
2003 Kirito K, Fox N, Kaushansky K. Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells. Blood. 102: 3172-8. PMID 12855555 DOI: 10.1182/blood-2003-03-0944  1
2003 Kaushansky K. Thrombopoietin: accumulating evidence for an important biological effect on the hematopoietic stem cell. Annals of the New York Academy of Sciences. 996: 39-43. PMID 12799280  1
2003 Kyriakides TR, Rojnuckarin P, Reidy MA, Hankenson KD, Papayannopoulou T, Kaushansky K, Bornstein P. Megakaryocytes require thrombospondin-2 for normal platelet formation and function. Blood. 101: 3915-23. PMID 12732502 DOI: 10.1182/blood.V101.10.3915  1
2003 Kaushansky K. Etiology of the myeloproliferative disorders: the role of thrombopoietin. Seminars in Hematology. 40: 6-9. PMID 12682875 DOI: 10.1053/shem.2003.50027  1
2002 Kaushansky K. Celebrate hematology. Blood. 100: 4257-8. PMID 12453874 DOI: 10.1182/blood-2002-09-2984  1
2002 Kaushansky K. Thrombopoietin: from theory to reality. International Journal of Hematology. 76: 343-5. PMID 12430879  1
2002 Fox N, Priestley G, Papayannopoulou T, Kaushansky K. Thrombopoietin expands hematopoietic stem cells after transplantation. The Journal of Clinical Investigation. 110: 389-94. PMID 12163458 DOI: 10.1172/JCI15430  1
2002 Linden HM, Kaushansky K. The glycan domain of thrombopoietin (TPO) acts in trans to enhance secretion of the hormone and other cytokines. The Journal of Biological Chemistry. 277: 35240-7. PMID 12101178 DOI: 10.1074/jbc.M201297200  1
2002 Habib T, Senadheera S, Weinberg K, Kaushansky K. The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3. Biochemistry. 41: 8725-31. PMID 12093291 DOI: 10.1021/bi0202023  1
2002 Kaushansky K, Drachman JG. The molecular and cellular biology of thrombopoietin: the primary regulator of platelet production. Oncogene. 21: 3359-67. PMID 12032774 DOI: 10.1038/sj.onc.1205323  1
2002 Kaushansky K, Fox N, Lin NL, Liles WC. Lineage-specific growth factors can compensate for stem and progenitor cell deficiencies at the postprogenitor cell level: an analysis of doubly TPO- and G-CSF receptor-deficient mice. Blood. 99: 3573-8. PMID 11986210 DOI: 10.1182/blood.V99.10.3573  1
2002 Drachman JG, Miyakawa Y, Luthi JN, Dahlen DD, Raney A, Geddis AE, Kaushansky K. Studies with chimeric Mpl/JAK2 receptors indicate that both JAK2 and the membrane-proximal domain of Mpl are required for cellular proliferation. The Journal of Biological Chemistry. 277: 23544-53. PMID 11980901 DOI: 10.1074/jbc.M201120200  1
2002 Zhao S, Zoller K, Masuko M, Rojnuckarin P, Yang XO, Parganas E, Kaushansky K, Ihle JN, Papayannopoulou T, Willerford DM, Clackson T, Blau CA. JAK2, complemented by a second signal from c-kit or flt-3, triggers extensive self-renewal of primary multipotential hemopoietic cells. The Embo Journal. 21: 2159-67. PMID 11980713 DOI: 10.1093/emboj/21.9.2159  1
2002 Geddis AE, Linden HM, Kaushansky K. Thrombopoietin: a pan-hematopoietic cytokine. Cytokine & Growth Factor Reviews. 13: 61-73. PMID 11750880 DOI: 10.1016/S1359-6101(01)00030-2  1
2001 Wang Q, Fox NE, Kaushansky K. Interferon-alpha directly inhibits thrombopoietin-induced megakaryocyte proliferation and differentiation Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. 22: 296-299. PMID 11877087  1
2001 Kaushansky K. Removing the cloud from industry-sponsored, multicentered clinical trials Blood. 98: 2001. PMID 11567981 DOI: 10.1182/blood.V98.7.2001  1
2001 Rojnuckarin P, Miyakawa Y, Fox NE, Deou J, Daum G, Kaushansky K. The roles of phosphatidylinositol 3-kinase and protein kinase Czeta for thrombopoietin-induced mitogen-activated protein kinase activation in primary murine megakaryocytes. The Journal of Biological Chemistry. 276: 41014-22. PMID 11535599 DOI: 10.1074/jbc.M106508200  1
2001 Carow CE, Fox NE, Kaushansky K. Kinetics of endomitosis in primary murine megakaryocytes Journal of Cellular Physiology. 188: 291-303. PMID 11473355 DOI: 10.1002/jcp.1120  1
2001 Geddis AE, Fox NE, Kaushansky K. Phosphatidylinositol 3-Kinase Is Necessary but Not Sufficient for Thrombopoietin-induced Proliferation in Engineered Mpl-bearing Cell Lines as Well as in Primary Megakaryocytic Progenitors Journal of Biological Chemistry. 276: 34473-34479. PMID 11418622 DOI: 10.1074/jbc.M105178200  1
2001 Kaushansky K. Small molecule mimics of hematopoietic growth factors: Improving on mother nature? Leukemia. 15: 673-674. PMID 11368377 DOI: 10.1038/sj/leu/2402058  1
2001 Kaushansky K. Access to the biomedical literature: A stand against coercion Blood. 97: 2195-2196. PMID 11290578 DOI: 10.1182/blood.V97.8.2195  1
2001 Rojnuckarin P, Kaushansky K. Actin reorganization and proplatelet formation in murine megakaryocytes: the role of protein kinase calpha. Blood. 97: 154-61. PMID 11133755 DOI: 10.1182/blood.V97.1.154  1
2001 Miyakawa Y, Rojnuckarin P, Habib T, Kaushansky K. Thrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytes. The Journal of Biological Chemistry. 276: 2494-502. PMID 11054408 DOI: 10.1074/jbc.M002633200  1
2001 Kaushansky K. Inside Blood: A roadmap to the best and brightest Blood. 97: 3. DOI: 10.1182/blood.V97.1.3  1
2000 Kaushansky K. Glossary of Molecular Biology Terminology. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 438-456. PMID 11701556  1
2000 Pastore S, Giustizieri ML, Mascia F, Giannetti A, Kaushansky K, Girolomoni G. Dysregulated activation of activator protein 1 in keratinocytes of atopic dermatitis patients with enhanced expression of granulocyte/macrophage-colony stimulating factor. The Journal of Investigative Dermatology. 115: 1134-43. PMID 11121152 DOI: 10.1046/j.1523-1747.2000.00149.x  1
2000 Parrish-Novak J, Dillon SR, Nelson A, Hammond A, Sprecher C, Gross JA, Johnston J, Madden K, Xu W, West J, Schrader S, Burkhead S, Heipel M, Brandt C, Kuijper JL, ... ... Kaushansky K, et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function Nature. 408: 57-63. PMID 11081504 DOI: 10.1038/35040504  1
2000 Wang Q, Miyakawa Y, Fox N, Kaushansky K. Interferon-α directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1 Blood. 96: 2093-2099. PMID 10979953  1
2000 Miyakawa Y, Drachman JG, Gallis B, Kaushansky A, Kaushansky K. A structure-function analysis of serine/threonine phosphorylation of the thrombopoietin receptor, c-Mpl Journal of Biological Chemistry. 275: 32214-32219. PMID 10918061  1
2000 Martin-Soudant N, Drachman JG, Kaushansky K, Nepveu A. CDP/Cut DNA binding activity is down-modulated in granulocytes, macrophages and erythrocytes but remains elevated in differentiating megakaryocytes Leukemia. 14: 863-873. PMID 10803519  1
2000 Kaushansky K. Use of thrombopoietic growth factors in acute leukemia Leukemia. 14: 505-508. PMID 10720151  1
2000 Linden HM, Kaushansky K. The glycan domain of thrombopoietin enhances its secretion Biochemistry. 39: 3044-3051. PMID 10715125 DOI: 10.1021/bi991756h  1
2000 Sabath DF, Lin N, Sabath DE, Kaushansky K, Broudy VC. Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin Cytokine. 12: 127-133. PMID 10671297 DOI: 10.1006/cyto.1999.0531  1
2000 Hodohara K, Fujii N, Yamamoto N, Kaushansky K. Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK) Blood. 95: 769-775. PMID 10648384  1
2000 Kaushansky K. Blood: New designs for a new millennium Blood. 95: 1-6. PMID 10607677  1
2000 Habib T, Kaushansky K. Bsterleukin-21 (il-21) and il-2 differentially activate stats and stats in baf3 and ctll cells Blood. 96.  1
2000 Kaushansky K. 'How I treat ...': A new style of clinical review article Blood. 96: 1205.  1
1999 Kaushansky K. Megakaryocyte growth factors and acute myeloid leukemia [7] Leukemia. 13: 1471. PMID 10483086  1
1999 Rojnuckarin P, Drachman JG, Kaushansky K. Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood. 94: 1273-82. PMID 10438715  1
1999 Sabath DF, Kaushansky K, Broudy VC. Deletion of the extracellular membrane-distal cytokine receptor homology module of Mpl results in constitutive cell growth and loss of thrombopoietin binding Blood. 94: 365-367. PMID 10381535  1
1999 Kaushansky K. The enigmatic megakaryocyte gradually reveals its secrets Bioessays. 21: 353-360. PMID 10377897  1
1999 Colman RW, Tracy PB, Camire RM, Pollak ES, Kaushansky K. Where does platelet factor V originate? [4] (multiple letters) Blood. 93: 3152-3153. PMID 10336271  1
1999 Drachman JG, Millett KM, Kaushansky K. Thrombopoietin signal transduction requires functional JAK2, not TYK2 Journal of Biological Chemistry. 274: 13480-13484. PMID 10224114 DOI: 10.1074/jbc.274.19.13480  1
1999 Drachman JG, Rojnuckarin P, Kaushansky K. Thrombopoietin signal transduction: studies from cell lines and primary cells. Methods (San Diego, Calif.). 17: 238-49. PMID 10080909 DOI: 10.1006/meth.1998.0734  1
1999 Kaushansky K. Evolution in blood: Editorial Blood. 93: 1441-1442.  1
1998 Li J, Franco RS, Wang Y, Pan HQ, Eaton D, Cheng T, Kaushansky K, Dai W. Megakaryocytic differentiation of HIMeg-1 cells induced by interferon γ and tumour necrosis factor α but not by thrombopoietin Cytokine. 10: 880-889. PMID 9878125 DOI: 10.1006/cyto.1998.0345  1
1998 Camire RM, Pollak ES, Kaushansky K, Tracy PB. Secretable human platelet-derived factor V originates from the plasma pool Blood. 92: 3035-3041. PMID 9787136  1
1998 Kaushansky K. The role of the MPL receptor in myeloproliferative disorders Leukemia. 12. PMID 9777896  1
1998 Jin L, Siritanaratkul N, Emery DW, Richard RE, Kaushansky K, Papayannopoulou T, Blau CA. Targeted expansion of genetically modified bone marrow cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 8093-7. PMID 9653145 DOI: 10.1073/pnas.95.14.8093  1
1998 Broudy VC, Kaushansky K. Biology of thrombopoietin Current Opinion in Pediatrics. 10: 60-64. PMID 9529640 DOI: 10.1097/00008480-199802000-00012  1
1998 Kaushansky K. Introduction: Megakaryocyte biology and pathophysiology Seminars in Hematology. 35: 182.  1
1998 Kaushansky K. Growth factors and hematopoietic cell fate: Introduction: A new feature: Controversies in hematology Blood. 92: 345.  1
1998 Hammond WP, Wun T, Kaplan A, Kaplan S, Paglieroni T, Kaushansky K, Foster DC. High concentrations of thrombopoietin activate platelets in vitro Clinical and Applied Thrombosis/Hemostasis. 4: 170-178.  1
1998 Kaushansky K. A new year greeting from a new editor Blood. 91: 1-2.  1
1997 Lansdorp PM, Lemischka IR, Dick JE, Spangrude GJ, Kaushansky K, Kanz L, Zanjani ED, Torok-Storb B, Griffin, Ogawa M, Eaves C, Quesenberry PJ. Intrinsic control of stem cell fate Stem Cells. 15: 223-227. PMID 9368346  1
1997 Ihle JN, Nosaka T, Thierfelder W, Quelle FW, Shimoda K. Jaks and Stats in cytokine signaling. Stem Cells (Dayton, Ohio). 15: 105-11; discussion 1. PMID 9368330 DOI: 10.1002/stem.5530150814  1
1997 Kaushansky K, Torok-Storb B, Fibbe WE, Broxmeyer HE, Moore MAS, Hoffman R, Ihle JN. Thrombopoietin: More than a lineage-specific megakaryocyte growth factor Stem Cells. 15: 97-103. PMID 9368329  1
1997 Broxmeyer HE, Mantel CR, Aronica SM, Kaushansky K, Griffin, Fibbe WE. Biology and mechanisms of action of synergistically stimulated myeloid progenitor cell proliferation and suppression by chemokines Stem Cells. 15: 69-78. PMID 9368327  1
1997 Bazil V, Brandt JE, Hoffman R, Kaushansky K, Lansdorp PM, Eaves C, Torok-Storb B, Sharkis SJ, Papayannopoulou T. Resistance of human hematopoietic stem cells to a monoclonal antibody recognizing CD43 Stem Cells. 15: 13-19. PMID 9368320  1
1997 Eaves C, Miller C, Cashman J, Conneally I, Petzer A, Zandstra P, Eaves A, Kaushansky K, Moore MAS, Dick JE, Lansdorp PM. Hematopoietic stem cells: Inferences from in vivo assays Stem Cells. 15: 1-5. PMID 9368318  1
1997 Kaushansky K. Thrombopoietin: Basic biology and clinical promise Leukemia. 11: 426-427. PMID 9209413  1
1997 Kaushansky K. Thrombopoietin: Platelets on demand? Annals of Internal Medicine. 126: 731-733. PMID 9139560  1
1997 Drachman JG, Kaushansky K. Dissecting the thrombopoietin receptor: Functional elements of the Mpl cytoplasmic domain Proceedings of the National Academy of Sciences of the United States of America. 94: 2350-2355. PMID 9122198 DOI: 10.1073/pnas.94.6.2350  1
1997 Wun T, Paglieroni T, Hammond WP, Kaushansky K, Foster DC. Thrombopoietin is synergistic with other hematopoietic growth factors and physiologic platelet agonists for platelet activation in vitro American Journal of Hematology. 54: 225-232. PMID 9067502 DOI: 10.1002/(SICI)1096-8652(199703)54:3<225::AID-AJH9>3.0.CO;2-Y  1
1997 Broudy VC, Lin NL, Sabath DF, Papayannopoulou T, Kaushansky K. Human platelets display high-affinity receptors for thrombopoietin Blood. 89: 1896-1904. PMID 9058709  1
1997 Kaushansky K. Thrombopoietin: Understanding and manipulating platelet production Annual Review of Medicine. 48: 1-11. PMID 9046940 DOI: 10.1146/annurev.med.48.1.1  1
1997 Drachman JG, Sabath DF, Fox NE, Kaushansky K. Thrombopoietin signal transduction in purified murine megakaryocytes Blood. 89: 483-492. PMID 9002950  1
1997 Kaushansky K. Thrombopoietin: The primary regulator of platelet production Trends in Endocrinology and Metabolism. 8: 45-50. DOI: 10.1016/S1043-2760(96)00269-X  1
1997 Kaushansky K. Thrombopoietin: In vitro predictions, in vivo realities Platelets. 8: 444-445. DOI: 10.1002/(SICI)1096-8652(199611)53:3<188::AID-AJH7>3.0.CO;2-V  1
1996 Kaushansky K, Broudy VC, Sitnicka E, Lofton-Day C, Grossmann A, Sprugel K. Do the preclinical effects of thrombopoietin correlate with its in vitro properties? Stem Cells. 14: 108-111. PMID 11012209  1
1996 Kaushansky K. Thrombopoietin and the physiology of platelet production Leukemia Research. 20: 705-707. PMID 8947578 DOI: 10.1016/0145-2126(96)00037-9  1
1996 Grossmann A, Lenox J, Deisher TA, Ren HP, Humes JM, Kaushansky K, Sprugel KH. Synergistic effects of thrombopoietin and granulocyte colony-stimulating factor on neutrophil recovery in myelosuppressed mice Blood. 88: 3363-3370. PMID 8896401  1
1996 Broudy VC, Lin NL, Fox N, Taga T, Saito M, Kaushansky K. Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit Blood. 88: 2026-2032. PMID 8822921  1
1996 Zucker-Franklin D, Kaushansky K. Effect of thrombopoietin on the development of megakaryocytes and platelets: An ultrastructural analysis Blood. 88: 1632-1638. PMID 8781418  1
1996 Kaushansky K. Thrombopoietin and platelet development Western Journal of Medicine. 164: 209-211. PMID 8775930  1
1996 Grossmann A, Lenox J, Ren HP, Humes JM, Forstrom JW, Kaushansky K, Sprugel KH. Thrombopoietin accelerates platelet, red blood cell, and neutrophil recovery in myelosuppressed mice Experimental Hematology. 24: 1238-1246. PMID 8765500  1
1996 Kaushansky K. The thrombocytopenia of cancer: Prospects for effective cytokine therapy Hematology/Oncology Clinics of North America. 10: 431-455. PMID 8707763 DOI: 10.1016/S0889-8588(05)70346-4  1
1996 Matous JV, Langley K, Kaushansky K. Structure-function relationships of stem cell factor: an analysis based on a series of human-murine stem cell factor chimera and the mapping of a neutralizing monoclonal antibody. Blood. 88: 437-44. PMID 8695790  1
1996 Kaushansky K, O'Rork C, Shoemaker SG, McCarty J. The regulation of GM-CSF is dependent on a complex interplay of multiple nuclear proteins. Molecular Immunology. 33: 461-70. PMID 8676897 DOI: 10.1016/0161-5890(95)00156-5  1
1996 Sitnicka E, Lin N, Priestley GV, Fox N, Broudy VC, Wolf NS, Kaushansky K. The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells Blood. 87: 4998-5005. PMID 8652812  1
1996 Fero ML, Rivkin M, Tasch M, Porter P, Carow CE, Firpo E, Polyak K, Tsai LH, Broudy V, Perlmutter RM, Kaushansky K, Roberts JM. A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice. Cell. 85: 733-44. PMID 8646781 DOI: 10.1016/S0092-8674(00)81239-8  1
1996 Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH, Broudy VC. Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice Experimental Hematology. 24: 265-269. PMID 8641351  1
1996 Turner KJ, Goldman SJ, Kaye JA, Clark SC. Thrombopoiesis and thrombopoietin: the significance of "non-Tpo" cytokines. Blood. 87: 3065-7. PMID 8639934  1
1996 Ku H, Yonemura Y, Kaushansky K, Ogawa M. Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice Blood. 87: 4544-4551. PMID 8639822  1
1996 Kaushansky K. Thrombopoietin: Biological and preclinical properties Leukemia. 10. PMID 8618473  1
1996 Papayannopoulou T, Brice M, Farrer D, Kaushansky K. Insights into the cellular mechanisms of erythropoietin-thrombopoietin synergy Experimental Hematology. 24: 660-669. PMID 8605971  1
1996 Karsan A, Yee E, Kaushansky K, Harlan JM. Cloning of human Bcl-2 homologue: inflammatory cytokines induce human A1 in cultured endothelial cells. Blood. 87: 3089-96. PMID 8605321  1
1996 Kaushansky K. Megakaryocytes: Their precursors and their progeny Trends in Cardiovascular Medicine. 6: 261-265. DOI: 10.1016/S1050-1738(96)00108-9  1
1996 Kaushansky K. Thrombopoietin: Does the in vitro biology correlate with its in vivo properties? Vox Sanguinis. 70: 41-43.  1
1995 Kaushansky K. Physiology and preclinical studies of thrombopoietin Current Opinion in Hematology. 2: 172-176. PMID 9371991  1
1995 Drachman JG, Kaushansky K. Structure and function of the cytokine receptor superfamily Current Opinion in Hematology. 2: 22-28. PMID 9371968  1
1995 Kaushansky K. Thrombopoietin: The primary regulator of megakaryocyte and platelet production Thrombosis and Haemostasis. 74: 521-525. PMID 8578518  1
1995 Monfardini C, Kieber-Emmons T, VonFeldt JM, O'Malley B, Rosenbaum H, Godillot AP, Kaushansky K, Brown CB, Voet D, McCallus DE. Recombinant antibodies in bioactive peptide design. The Journal of Biological Chemistry. 270: 6628-38. PMID 7896802 DOI: 10.1074/jbc.270.12.6628  1
1995 Brown CB, Beaudry P, Laing TD, Shoemaker S, Kaushansky K. In vitro characterization of the human recombinant soluble granulocyte-macrophage colony-stimulating factor receptor. Blood. 85: 1488-95. PMID 7888670  1
1995 McDonald TP, Wendling F, Vainchenker W, McCarty JM, Jorgenson MJ, Kaushansky K. Thrombopoietin from human embryonic kidney cells is the same factor as c-mpl-ligand. Blood. 85: 292-4. PMID 7803805  1
1995 Broudy VC, Kaushansky K. Thrombopoietin, the c-mpl ligand, is a major regulator of platelet production Journal of Leukocyte Biology. 57: 719-725. PMID 7759951  1
1995 McDonald TP, Sullivan PS, Kaushansky K. Defining units for thrombopoietin [5] Blood. 85: 1975-1976. PMID 7703503  1
1995 Kaushansky K. Thrombopoietin: Basic biology, clinical promise International Journal of Hematology. 62: 7-15. PMID 7670009  1
1995 Kaushansky K, Broudy VC, Grossmann A, Humes J, Lin N, Hong Ping Ren, Bailey MC, Papayannopoulou T, Forstrom JW, Sprugel KH. Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy Journal of Clinical Investigation. 96: 1683-1687. PMID 7657840  1
1995 Fibbe WE, Heemskerk DPM, Laterveer L, Pruijt JFM, Foster D, Kaushansky K, Willemze R. Accelerated reconstitution of platelets and erythrocytes after syngeneic transplantation of bone marrow cells derived from thrombopoietin pretreated donor mice Blood. 86: 3308-3313. PMID 7579432  1
1995 McCarty JM, Sprugel KH, Fox NE, Sabath DE, Kaushansky K. Murine thrombopoietin mRNA levels are modulated by platelet count Blood. 86: 3668-3675. PMID 7579332  1
1995 McCarty JM, Yee EK, Deisher TA, Harlan JM, Kaushansky K. Interleukin-4 induces endothelial vascular cell adhesion molecule-1 (VCAM-1) by an NF-kappa b-independent mechanism. Febs Letters. 372: 194-8. PMID 7556668 DOI: 10.1016/0014-5793(95)00976-G  1
1995 Sattler M, Durstin MA, Frank DA, Okuda K, Kaushansky K, Salgia R, Griffin JD. The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases Experimental Hematology. 23: 1040-1048. PMID 7543416  1
1995 Kaushansky K, Broudy VC, Lin N, Jorgensen MJ, McCarty J, Fox N, Zucker-Franklin D, Lofton-Day C. Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development. Proceedings of the National Academy of Sciences of the United States of America. 92: 3234-8. PMID 7536928  1
1995 Broudy VC, Lin NL, Kaushansky K. Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro Blood. 85: 1719-1726. PMID 7535585  1
1995 Drachman JG, Griffin JD, Kaushansky K. The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and c-Mpl Journal of Biological Chemistry. 270: 4979-4982. PMID 7534285 DOI: 10.1074/jbc.270.10.4979  1
1995 Kaushansky K. Thrombopoietin: Biological expectations and physiologic surprises Cancer Forum. 19: 283-285.  1
1994 Kaushansky K, Lok S, Holly RD, Broudy VC, Lin N, Bailey MC, Forstrom JW, Buddle MM, Oort PJ, Hagen FS, Roth GJ, Papayannopoulou T, Foster DC. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Nature. 369: 568-571. PMID 8202159  1
1994 Kaushansky K, Shoemaker SG, O'Rork CA, McCarty JM. Coordinate regulation of multiple human lymphokine genes by Oct-1 and potentially novel 45 and 43 kDa polypeptides. Journal of Immunology (Baltimore, Md. : 1950). 152: 1812-20. PMID 8120390  1
1994 Derigs HG, Reifel-Miller A, Kaushansky K, Hromas RA, Boswell HS. Granulocyte-macrophage colony-stimulating factor expression is regulated at transcriptional and posttranscriptional levels in a murine bone marrow stromal cell line Experimental Hematology. 22: 924-932. PMID 8062890  1
1994 Brown CB, Pihl CE, Kaushansky K. Mapping of Human Granulocyte‐Macrophage‐Colony‐Stimulating‐Factor Domains Interacting with the Human Granulocyte‐Macrophage‐Colony‐Stimulating‐Factor‐Receptor α‐Subunit European Journal of Biochemistry. 225: 873-880. PMID 7957224 DOI: 10.1111/j.1432-1033.1994.0873b.x  1
1994 Kaushansky K. Molecular biology glossary Revista De Investigacion Clinica. 168-180. PMID 7886302  1
1994 Kaushansky K. The mpl ligand: Molecular and cellular biology of the critical regulator of megakaryocyte development Stem Cells. 12: 91-96. PMID 7696972  1
1993 Park JH, Kaushansky K, Levitt L. Transcriptional regulation of interleukin 3 (IL3) in primary human T lymphocytes. Role of AP-1- and octamer-binding proteins in control of IL3 gene expression. The Journal of Biological Chemistry. 268: 6299-308. PMID 8454603  1
1993 Kaushansky K, Karplus PA. Hematopoietic growth factors: Understanding functional diversity in structural terms Blood. 82: 3229-3240. PMID 8241495  1
1993 Deisher TA, Haddix TL, Montgomery KF, Pohlman TH, Kaushansky K, Harlan JM. The role of protein kinase C in the induction of VCAM-1 expression on human umbilical vein endothelial cells Febs Letters. 331: 285-290. PMID 7690717 DOI: 10.1016/0014-5793(93)80354-W  1
1993 Deisher TA, Kaushansky K, Harlan JM. Inhibitors of topoisomerase II prevent cytokine-induced expression of vascular cell adhesion molecule-1, while augmenting the expression of endothelial leukocyte adhesion molecule-1 on human umbilical vein endothelial cells Cell Communication and Adhesion. 1: 133-142. PMID 7521751 DOI: 10.3109/15419069309095689  1
1992 Kaushansky K, Lopez JA, Brown CB. Role of carbohydrate modification in the production and secretion of human granulocyte macrophage colony-stimulating factor in genetically engineered and normal mesenchymal cells Biochemistry. 31: 1881-1886. PMID 1737041  1
1992 Kaushansky K. Structure-function relationships of the hematopoietic growth factors Proteins: Structure, Function and Genetics. 12: 1-9. PMID 1553378  1
1992 Kaushansky K, Shoemaker SG, Broudy VC, Lin NL, Matous JV, Alderman EM, Aghajanian JD, Szklut PJ, VanDyke RE, Pearce MK. Structure-function relationships of interleukin-3. An analysis based on the function and binding characteristics of a series of interspecies chimera of gibbon and murine interleukin-3. The Journal of Clinical Investigation. 90: 1879-88. PMID 1385477 DOI: 10.1172/JCI116065  1
1991 Alvaro-Gracia JM, Zvaifler NJ, Brown CB, Kaushansky K, Firestein GS. Cytokines in chronic inflammatory arthritis: VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-α Journal of Immunology. 146: 3365-3371. PMID 2026869  1
1991 Hromas R, Collins S, Raskind W, Deaven L, Kaushansky K. Hem-1, a potential membrane protein, with expression restricted to blood cells Bba - Gene Structure and Expression. 1090: 241-244. PMID 1932118 DOI: 10.1016/0167-4781(91)90109-Y  1
1991 Schaafsma MR, Falkenburg JH, Landegent JE, Duinkerken N, Osanto S, Ralph P, Kaushansky K, Wagemaker G, Van Damme J, Willemze R. In vivo production of interleukin-5, granulocyte-macrophage colony-stimulating factor, macrophages colony-stimulating factor, and interleukin-6 during intravenous administration of high-dose interleukin-2 in cancer patients. Blood. 78: 1981-7. PMID 1912580  1
1991 Hromas R, Collins SJ, Hickstein D, Raskind W, Deaven LL, O'Hara P, Hagen FS, Kaushansky K. A retinoic acid-responsive human zinc finger gene, MZF-1, preferentially expressed in myeloid cells Journal of Biological Chemistry. 266: 14183-14187. PMID 1860835  1
1991 Kaushansky K, Brown CB, Petersdorf S. Hematopoietic colony-stimulating factors Biotechnology (Reading, Mass.). 19: 365-395. PMID 1723913  1
1991 Bavisotto L, Kaushansky K, Lin N, Hromas R. Antisense oligonucleotides from the stage-specific myeloid zinc finger gene MZF-1 inhibit granulopoiesis in vitro Journal of Experimental Medicine. 174: 1097-1101. PMID 1719120  1
1991 Meropol NJ, Kreider BL, Lee VMY, Kaushansky K, Prystowsky MB. A neutralizing monoclonal antibody binds to an epitope near the amino terminus of murine granulocyte-macrophage colony-stimulating factor Hybridoma. 10: 433-447. PMID 1718842  1
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