| Year |
Citation |
Score |
| 2023 |
Philpott JM, Freeberg AM, Park J, Lee K, Ricci CG, Hunt SR, Narasimamurthy R, Segal DH, Robles R, Cai Y, Tripathi S, McCammon JA, Virshup DM, Chiu JC, Lee C, et al. PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period. Molecular Cell. 83: 1677-1692.e8. PMID 37207626 DOI: 10.1016/j.molcel.2023.04.019 |
0.452 |
|
| 2022 |
Francisco JC, Virshup DM. Casein Kinase 1 and Human Disease: Insights From the Circadian Phosphoswitch. Frontiers in Molecular Biosciences. 9: 911764. PMID 35720131 DOI: 10.3389/fmolb.2022.911764 |
0.491 |
|
| 2021 |
Narasimamurthy R, Virshup DM. The phosphorylation switch that regulates ticking of the circadian clock. Molecular Cell. PMID 33545069 DOI: 10.1016/j.molcel.2021.01.006 |
0.463 |
|
| 2020 |
Masuda S, Narasimamurthy R, Yoshitane H, Kim JK, Fukada Y, Virshup DM. Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch. Proceedings of the National Academy of Sciences of the United States of America. PMID 32354999 DOI: 10.1073/Pnas.2000266117 |
0.538 |
|
| 2020 |
Philpott JM, Narasimamurthy R, Ricci CG, Freeberg AM, Hunt SR, Yee LE, Pelofsky RS, Tripathi S, Virshup DM, Partch CL. Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch. Elife. 9. PMID 32043967 DOI: 10.7554/Elife.52343 |
0.534 |
|
| 2020 |
Philpott JM, Narasimamurthy R, Ricci CG, Freeberg AM, Hunt SR, Yee LE, Pelofsky RS, Tripathi S, Virshup DM, Partch CL. Author response: Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch Elife. DOI: 10.7554/Elife.52343.Sa2 |
0.423 |
|
| 2020 |
Ricci CG, Philpott JM, Narasimamurthy R, Freeberg AM, Hunt SR, Yee LE, Pelofsky RS, Tripathi S, Virshup DM, Partch CL. Free Energy Landscape of Casein Kinase Delta and its Implications for Circadian Rhythm Biophysical Journal. 118: 207a-208a. DOI: 10.1016/J.Bpj.2019.11.1243 |
0.437 |
|
| 2019 |
Zhong Z, Virshup DM. Wnt signaling and drug resistance in cancer. Molecular Pharmacology. PMID 31787618 DOI: 10.1124/Mol.119.117978 |
0.325 |
|
| 2019 |
Idris M, Harmston N, Petretto EG, Madan B, Virshup DM. Broad regulation of gene isoform expression by Wnt signaling in cancer. Rna (New York, N.Y.). PMID 31506381 DOI: 10.1261/Rna.071506.119 |
0.394 |
|
| 2019 |
Zhong Z, Sepramaniam S, Chew XH, Wood K, Lee MA, Madan B, Virshup DM. PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers. Oncogene. PMID 31391551 DOI: 10.1038/S41388-019-0908-1 |
0.32 |
|
| 2019 |
Fadhlullah SFB, Halim NBA, Yeo JYT, Ho RLY, Um P, Ang BT, Tang C, Ng WH, Virshup DM, Ho IAW. Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness. Oncogene. PMID 30967630 DOI: 10.1038/S41388-019-0809-3 |
0.308 |
|
| 2019 |
Moti N, Yu J, Boncompain G, Perez F, Virshup DM. Wnt traffic from endoplasmic reticulum to filopodia. Plos One. 14: e0212711. PMID 30794657 DOI: 10.1371/Journal.Pone.0212711 |
0.317 |
|
| 2019 |
Greicius G, Virshup DM. Stromal control of intestinal development and the stem cell niche. Differentiation; Research in Biological Diversity. PMID 30683451 DOI: 10.1016/J.Diff.2019.01.001 |
0.315 |
|
| 2018 |
Fu NY, Pal B, Chen Y, Jackling FC, Milevskiy M, Vaillant F, Capaldo BD, Guo F, Liu KH, Rios AC, Lim N, Kueh AJ, Virshup DM, Herold MJ, Tucker HO, et al. Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence. Developmental Cell. 47: 629-644.e8. PMID 30523786 DOI: 10.1016/J.Devcel.2018.10.001 |
0.339 |
|
| 2018 |
Madan B, Harmston N, Nallan G, Montoya A, Faull P, Petretto E, Virshup DM. Temporal dynamics of Wnt-dependent transcriptome reveals an oncogenic Wnt/MYC/ribosome axis. The Journal of Clinical Investigation. PMID 30300142 DOI: 10.1172/Jci122383 |
0.384 |
|
| 2018 |
Mattes B, Dang Y, Greicius G, Kaufmann LT, Prunsche B, Rosenbauer J, Stegmaier J, Mikut R, Özbek S, Nienhaus GU, Schug A, Virshup DM, Scholpp S. Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. Elife. 7. PMID 30060804 DOI: 10.7554/Elife.36953 |
0.37 |
|
| 2018 |
Kabiri Z, Greicius G, Zaribafzadeh H, Hemmerich A, Counter CM, Virshup DM. Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells. The Journal of Clinical Investigation. PMID 30059017 DOI: 10.1172/Jci99325 |
0.373 |
|
| 2018 |
Fustin JM, Kojima R, Itoh K, Chang HY, Ye S, Zhuang B, Oji A, Gibo S, Narasimamurthy R, Virshup D, Kurosawa G, Doi M, Manabe I, Ishihama Y, Ikawa M, et al. Correction: Two Ck1δ transcripts regulated by m6A meth-ylation code for two antagonistic kinases in the control of the circadian clock (Proceedings of the National Academy of Sciences of the United States of America (2018) 115 (5980-5985) DOI: 10.1073/pnas.1721371115) Proceedings of the National Academy of Sciences of the United States of America. 115. PMID 29941566 DOI: 10.1073/Pnas.1809838115 |
0.409 |
|
| 2018 |
Narasimamurthy R, Hunt SR, Lu Y, Fustin JM, Okamura H, Partch CL, Forger DB, Kim JK, Virshup DM. CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch. Proceedings of the National Academy of Sciences of the United States of America. PMID 29784789 DOI: 10.1073/Pnas.1721076115 |
0.59 |
|
| 2018 |
Fustin JM, Kojima R, Itoh K, Chang HY, Shiqi Y, Zhuang B, Oji A, Gibo S, Narasimamurthy R, Virshup D, Kurosawa G, Doi M, Manabe I, Ishihama Y, Ikawa M, et al. Two transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock. Proceedings of the National Academy of Sciences of the United States of America. PMID 29784786 DOI: 10.1073/Pnas.1721371115 |
0.529 |
|
| 2018 |
Greicius G, Kabiri Z, Sigmundsson K, Liang C, Bunte R, Singh MK, Virshup DM.
pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 29559533 DOI: 10.1073/Pnas.1713510115 |
0.311 |
|
| 2018 |
Lee HY, Itahana Y, Schuechner S, Fukuda M, Je HS, Ogris E, Virshup DM, Itahana K. Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis. Science Signaling. 11. PMID 29317521 DOI: 10.1126/Scisignal.Aam7893 |
0.322 |
|
| 2017 |
Zhang F, Virshup DM, Cheong JK. Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis. Oncogene. PMID 28945225 DOI: 10.1038/Onc.2017.334 |
0.39 |
|
| 2017 |
Ho SY, Alam J, Jeyaraj DA, Wang W, Lin GR, Ang SH, Tan ESW, Lee MA, Ke Z, Madan B, Virshup DM, Ding LJ, Manoharan V, Chew YS, Low CB, et al. Scaffold hopping and Optimization of Maleimide based Porcupine Inhibitors. Journal of Medicinal Chemistry. PMID 28671458 DOI: 10.1021/Acs.Jmedchem.7B00662 |
0.323 |
|
| 2017 |
Eng GWL, Edison, Virshup DM. Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2. Plos One. 12: e0177834. PMID 28545154 DOI: 10.1371/Journal.Pone.0177834 |
0.581 |
|
| 2017 |
Narasimamurthy R, Virshup DM. A Flick of the Tail Keeps the Circadian Clock in Line. Molecular Cell. 66: 437-438. PMID 28525736 DOI: 10.1016/J.Molcel.2017.05.008 |
0.377 |
|
| 2017 |
Narasimamurthy R, Virshup DM. Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock. Frontiers in Neurology. 8: 161. PMID 28496429 DOI: 10.3389/Fneur.2017.00161 |
0.372 |
|
| 2017 |
Alok A, Lei Z, Jagannathan NS, Kaur S, Rozen SG, Tucker-Kellogg L, Virshup DM. Wnts synergize to activate β-catenin signaling. Journal of Cell Science. PMID 28289266 DOI: 10.1242/Jcs.198093 |
0.314 |
|
| 2017 |
Alok A, Lei Z, Jagannathan NS, Kaur S, Harmston N, Rozen SG, Tucker-Kellogg L, Virshup DM. Wnt proteins synergize to activate β-catenin signaling Development. 144: e1.1-e1.1. DOI: 10.1242/Dev.154112 |
0.324 |
|
| 2017 |
Pendharkar V, Chew YS, Manoharan V, Low CB, Ong HE, Ho SY, Wang WL, Athisayamani JD, Madan B, Virshup D, Keller TH, Lee MA, Matter A, Hill J, Sangthongpitag K. Abstract 1172:In vivopharmacokinetic properties and antitumor efficacy of porcupine lead inhibitors in the orthotopic murine MMTV-Wnt1 breast tumor model and the human HPAF-II pancreatic xenograft mouse model Cancer Research. 77: 1172-1172. DOI: 10.1158/1538-7445.Am2017-1172 |
0.315 |
|
| 2016 |
Cheong JK, Virshup DM. CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers? Annals of Translational Medicine. 4: 433. PMID 27942524 DOI: 10.21037/Atm.2016.11.07 |
0.352 |
|
| 2016 |
Lim SK, Lu SY, Kang SA, Tan HJ, Li Z, Adrian Wee ZN, Guan JS, Reddy Chichili VP, Sivaraman J, Putti T, Thike AA, Tan PH, Sudol M, Virshup DM, Chan SW, et al. Wnt signaling promotes breast cancer by blocking ITCH-mediated degradation of the YAP/TAZ transcriptional coactivator WBP2. Cancer Research. PMID 27578003 DOI: 10.1158/0008-5472.Can-15-3537 |
0.364 |
|
| 2016 |
Wang J, Wang Z, Yu T, Yang H, Virshup DM, Kops GJ, Lee SH, Zhou W, Li X, Xu W, Rao Z. Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization. Protein & Cell. PMID 27350047 DOI: 10.1007/S13238-016-0283-4 |
0.552 |
|
| 2016 |
Cheong JK, Virshup DM. Keeping autophagy in cheCK1. Molecular & Cellular Oncology. 3: e1045117. PMID 27314070 DOI: 10.1080/23723556.2015.1045117 |
0.35 |
|
| 2016 |
Madan B, Walker MP, Young R, Quick L, Orgel KA, Ryan M, Gupta P, Henrich IC, Ferrer M, Marine S, Roberts BS, Arthur WT, Berndt JD, Oliveira AM, Moon RT, ... Virshup DM, et al. USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds. Proceedings of the National Academy of Sciences of the United States of America. PMID 27162353 DOI: 10.1073/Pnas.1605691113 |
0.382 |
|
| 2016 |
Madan B, Ke Z, Lei ZD, Oliver FA, Oshima M, Lee MA, Rozen S, Virshup DM. NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition. Oncotarget. PMID 26848981 DOI: 10.18632/Oncotarget.7157 |
0.347 |
|
| 2016 |
Somarelli JA, Schaeffer D, Marengo MS, Bepler T, Rouse D, Ware KE, Hish AJ, Zhao Y, Buckley AF, Epstein JI, Armstrong AJ, Virshup DM, Garcia-Blanco MA. Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. Oncogene. PMID 26751776 DOI: 10.1038/Onc.2015.497 |
0.336 |
|
| 2016 |
Asad M, Wong MK, Tan TZ, Virshup D, Thiery JP, Huang RY. Abstract A30: Frizzled-7 (FZD7)-mediated non-canonical Wnt-Planar Cell Polarity (PCP) signalling pathway as a novel molecular driver for the C5/Proliferative/Stem-A molecular subtype of ovarian cancer. Clinical Cancer Research. 22. DOI: 10.1158/1557-3265.Ovca15-A30 |
0.303 |
|
| 2016 |
Madan B, Ke Z, Harmston N, Petretto E, Hill J, Keller TH, Lee MA, Matter A, Virshup DM. Abstract B13: ETC-159 is a novel PORCN inhibitor effective for treatment of Wnt-addicted genetically defined cancers Molecular Cancer Research. 14. DOI: 10.1158/1557-3125.Devbiolca15-B13 |
0.376 |
|
| 2016 |
Cai W, Cheong J, Edison E, Banerjee A, Tan T, Gaboury L, Yousef E, Thiery J, Lobie P, Virshup D, Yap C, Kumar A. Abstract P4-08-03: DEAD-box RNA helicase DP103 as a novel regulator of Wnt/β-catenin signaling pathway and promotes cancer stem cell-like behavior in triple negative breast cancers Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P4-08-03 |
0.317 |
|
| 2015 |
Zhou M, Kim JK, Eng GW, Forger DB, Virshup DM. A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. Molecular Cell. 60: 77-88. PMID 26431025 DOI: 10.1016/J.Molcel.2015.08.022 |
0.476 |
|
| 2015 |
Xiang W, Cheong JK, Ang SH, Teo B, Xu P, Asari K, Sun WT, Than H, Bunte RM, Virshup DM, Chuah C. Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration. Oncotarget. PMID 26378050 DOI: 10.1182/Blood.V124.21.514.514 |
0.346 |
|
| 2015 |
Madan B, Ke Z, Harmston N, Ho SY, Frois AO, Alam J, Jeyaraj DA, Pendharkar V, Ghosh K, Virshup IH, Manoharan V, Ong EH, Sangthongpitag K, Hill J, Petretto E, ... ... Virshup DM, et al. Wnt addiction of genetically defined cancers reversed by PORCN inhibition. Oncogene. PMID 26257057 DOI: 10.1038/Onc.2015.280 |
0.357 |
|
| 2015 |
Duraiswamy AJ, Lee MA, Madan B, Ang SH, Tan ES, Cheong WW, Ke Z, Pendharkar V, Ding LJ, Chew YS, Manoharan V, Sangthongpitag K, Alam J, Poulsen A, Ho SY, ... Virshup DM, et al. Discovery and Optimization of a Porcupine Inhibitor. Journal of Medicinal Chemistry. PMID 26110200 DOI: 10.1021/Acs.Jmedchem.5B00507 |
0.374 |
|
| 2015 |
Madan B, Virshup DM. Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs. Molecular Cancer Therapeutics. 14: 1087-94. PMID 25901018 DOI: 10.1158/1535-7163.Mct-14-1038 |
0.355 |
|
| 2015 |
Cheong JK, Zhang F, Chua PJ, Bay BH, Thorburn A, Virshup DM. Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. The Journal of Clinical Investigation. 125: 1401-18. PMID 25798617 DOI: 10.1172/Jci78018 |
0.407 |
|
| 2015 |
Virshup DM. Moving upstream in the war on WNTs. The Journal of Clinical Investigation. 125: 975-7. PMID 25689251 DOI: 10.1172/Jci80819 |
0.303 |
|
| 2015 |
Yim DG, Ghosh S, Guy GR, Virshup DM. Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene. 34: 474-84. PMID 24469046 DOI: 10.1038/Onc.2013.564 |
0.48 |
|
| 2015 |
Ke Z, Madan B, Lim SQy, Wang S, Alam J, Ho SY, Jeyaraj DA, Ghosh K, Chew YS, Ding LJ, Monoharan V, Pendharkar V, Ong E, Hill J, Sangthongpitag K, ... ... Virshup DM, et al. Abstract 4449: A novel Porcupine inhibitor is effective in the treatment of cancers with RNF43 mutations Cancer Research. 75: 4449-4449. DOI: 10.1158/1538-7445.Am2015-4449 |
0.34 |
|
| 2014 |
Yu J, Virshup DM. Updating the Wnt pathways. Bioscience Reports. 34. PMID 25208913 DOI: 10.1042/Bsr20140119 |
0.349 |
|
| 2014 |
Low ICC, Loh T, Huang Y, Virshup DM, Pervaiz S. Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56 δ stabilizes its antiapoptotic activity Blood. 124: 2223-2234. PMID 25082878 DOI: 10.1182/Blood-2014-03-563296 |
0.482 |
|
| 2014 |
Asad M, Wong MK, Tan TZ, Choolani M, Low J, Mori S, Virshup D, Thiery JP, Huang RY. FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. Cell Death & Disease. 5: e1346. PMID 25032869 DOI: 10.1038/Cddis.2014.302 |
0.391 |
|
| 2014 |
MacDonald BT, Hien A, Zhang X, Iranloye O, Virshup DM, Waterman ML, He X. Disulfide bond requirements for active Wnt ligands. The Journal of Biological Chemistry. 289: 18122-36. PMID 24841207 DOI: 10.1074/Jbc.M114.575027 |
0.314 |
|
| 2014 |
Low ICC, Loh T, Virshup D, Pervaiz S. Abstract 5278: Superoxide mediated selective tyrosine nitration of protein phosphatase 2A-B56δ stabilizes Bcl-2 phosphorylation and its anti-apoptotic activity Cancer Research. 74: 5278-5278. DOI: 10.1158/1538-7445.Am2014-5278 |
0.462 |
|
| 2013 |
Xu P, Raetz EA, Kitagawa M, Virshup DM, Lee SH. BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression. Biology Open. 2: 479-86. PMID 23789096 DOI: 10.1242/Bio.20134051 |
0.319 |
|
| 2013 |
Yim DG, Virshup DM. Unwinding the Wnt action of casein kinase 1. Cell Research. 23: 737-8. PMID 23567556 DOI: 10.1038/Cr.2013.51 |
0.504 |
|
| 2013 |
Proffitt KD, Madan B, Ke Z, Pendharkar V, Ding L, Lee MA, Hannoush RN, Virshup DM. Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer Research. 73: 502-7. PMID 23188502 DOI: 10.1158/0008-5472.Can-12-2258 |
0.316 |
|
| 2013 |
Madan B, Ke Z, Lim SQy, Alam J, Ho SY, Jeyaraj DA, Ghosh K, Chew YS, Aliyev J, Ding LJ, Pendharkar V, Wang S, Sangthongpitag K, Keller T, Lee MA, ... Virshup DM, et al. Abstract C248: Novel PORCN inhibitors are safe and effective in the treatment of WNT-dependent cancers. Molecular Cancer Therapeutics. 12. DOI: 10.1158/1535-7163.Targ-13-C248 |
0.349 |
|
| 2013 |
Pervaiz S, Low I, Virshup D. Selective Tyrosine Nitration of Protein Phosphatase 2A-B56δ Mediates Superoxide-Induced Bcl-2 Activation Free Radical Biology and Medicine. 65: S23. DOI: 10.1016/J.Freeradbiomed.2013.10.438 |
0.347 |
|
| 2012 |
Proffitt KD, Virshup DM. Precise regulation of porcupine activity is required for physiological Wnt signaling. The Journal of Biological Chemistry. 287: 34167-78. PMID 22888000 DOI: 10.1074/Jbc.M112.381970 |
0.387 |
|
| 2012 |
Najdi R, Proffitt K, Sprowl S, Kaur S, Yu J, Covey TM, Virshup DM, Waterman ML. A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. Differentiation; Research in Biological Diversity. 84: 203-13. PMID 22784633 DOI: 10.1016/J.Diff.2012.06.004 |
0.361 |
|
| 2012 |
Covey TM, Kaur S, Tan Ong T, Proffitt KD, Wu Y, Tan P, Virshup DM. PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation. Plos One. 7: e34532. PMID 22509316 DOI: 10.1371/Journal.Pone.0034532 |
0.403 |
|
| 2012 |
Coombs GS, Schmitt AA, Canning CA, Alok A, Low IC, Banerjee N, Kaur S, Utomo V, Jones CM, Pervaiz S, Toone EJ, Virshup DM. Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer. Oncogene. 31: 213-25. PMID 21666721 DOI: 10.1038/Onc.2011.228 |
0.312 |
|
| 2011 |
Cheong JK, Nguyen TH, Wang H, Tan P, Voorhoeve PM, Lee SH, Virshup DM. IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene. 30: 2558-69. PMID 21258417 DOI: 10.1038/Onc.2010.627 |
0.387 |
|
| 2011 |
Cheong JK, Virshup DM. Casein kinase 1: Complexity in the family. The International Journal of Biochemistry & Cell Biology. 43: 465-9. PMID 21145983 DOI: 10.1016/J.Biocel.2010.12.004 |
0.566 |
|
| 2010 |
Virshup DM, Kaldis P. Cell biology. Enforcing the Greatwall in mitosis. Science (New York, N.Y.). 330: 1638-9. PMID 21164006 DOI: 10.1126/Science.1199898 |
0.51 |
|
| 2010 |
Covey TM, Edes K, Coombs GS, Virshup DM, Fitzpatrick FA. Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. Plos One. 5: e13545. PMID 20975834 DOI: 10.1371/Journal.Pone.0013545 |
0.369 |
|
| 2010 |
Coombs GS, Yu J, Canning CA, Veltri CA, Covey TM, Cheong JK, Utomo V, Banerjee N, Zhang ZH, Jadulco RC, Concepcion GP, Bugni TS, Harper MK, Mihalek I, Jones CM, ... ... Virshup DM, et al. WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification. Journal of Cell Science. 123: 3357-67. PMID 20826466 DOI: 10.1242/Jcs.072132 |
0.396 |
|
| 2009 |
McCulloch MW, Bugni TS, Concepcion GP, Coombs GS, Harper MK, Kaur S, Mangalindan GC, Mutizwa MM, Veltri CA, Virshup DM, Ireland CM. Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp. Journal of Natural Products. 72: 1651-6. PMID 19778090 DOI: 10.1021/Np900336F |
0.34 |
|
| 2009 |
Wang C, Chang KC, Somers G, Virshup D, Ang BT, Tang C, Yu F, Wang H. Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells. Development (Cambridge, England). 136: 2287-96. PMID 19502489 DOI: 10.1242/Dev.035758 |
0.429 |
|
| 2009 |
Virshup DM, Forger DB. Keeping the beat in the rising heat. Cell. 137: 602-4. PMID 19450508 DOI: 10.1016/J.Cell.2009.04.051 |
0.328 |
|
| 2009 |
Virshup DM, Shenolikar S. From promiscuity to precision: protein phosphatases get a makeover. Molecular Cell. 33: 537-45. PMID 19285938 DOI: 10.1016/J.Molcel.2009.02.015 |
0.488 |
|
| 2009 |
McCulloch MW, Coombs GS, Banerjee N, Bugni TS, Cannon KM, Harper MK, Veltri CA, Virshup DM, Ireland CM. Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives. Bioorganic & Medicinal Chemistry. 17: 2189-98. PMID 19022675 DOI: 10.1016/J.Bmc.2008.10.077 |
0.347 |
|
| 2009 |
Cheong JK, Virshup DM. Abstract B264: IC261 induces cell cycle arrest and apoptosis of human cancer cells via a CK1δ/ε independent mechanism Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-B264 |
0.358 |
|
| 2009 |
Wang C, Chang K, Somers G, Virshup D, Ti Ang B, Tang C, Yu F, Wang H. 08-P022 Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells Mechanisms of Development. 126: S150. DOI: 10.1016/J.Mod.2009.06.329 |
0.314 |
|
| 2008 |
Coombs GS, Covey TM, Virshup DM. Wnt signaling in development, disease and translational medicine. Current Drug Targets. 9: 513-31. PMID 18673238 DOI: 10.2174/138945008784911796 |
0.328 |
|
| 2008 |
Meng QJ, Logunova L, Maywood ES, Gallego M, Lebiecki J, Brown TM, Sládek M, Semikhodskii AS, Glossop NR, Piggins HD, Chesham JE, Bechtold DA, Yoo SH, Takahashi JS, Virshup DM, et al. Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. Neuron. 58: 78-88. PMID 18400165 DOI: 10.1016/J.Neuron.2008.01.019 |
0.459 |
|
| 2007 |
Virshup DM, Eide EJ, Forger DB, Gallego M, Harnish EV. Reversible protein phosphorylation regulates circadian rhythms. Cold Spring Harbor Symposia On Quantitative Biology. 72: 413-20. PMID 18419299 DOI: 10.1101/Sqb.2007.72.048 |
0.833 |
|
| 2007 |
Forester CM, Maddox J, Louis JV, Goris J, Virshup DM. Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. Proceedings of the National Academy of Sciences of the United States of America. 104: 19867-72. PMID 18056802 DOI: 10.1073/Pnas.0709879104 |
0.501 |
|
| 2007 |
Forger D, Gonze D, Virshup D, Welsh DK. Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward. Journal of Biological Rhythms. 22: 200-10. PMID 17517910 DOI: 10.1177/0748730407301823 |
0.347 |
|
| 2007 |
Tsai IC, Amack JD, Gao ZH, Band V, Yost HJ, Virshup DM. A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Developmental Cell. 12: 335-47. PMID 17336901 DOI: 10.1016/J.Devcel.2007.02.009 |
0.676 |
|
| 2007 |
Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, Virshup DM. Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. The Embo Journal. 26: 1511-21. PMID 17318175 DOI: 10.1038/Sj.Emboj.7601607 |
0.454 |
|
| 2007 |
Gallego M, Virshup DM. Post-translational modifications regulate the ticking of the circadian clock. Nature Reviews. Molecular Cell Biology. 8: 139-48. PMID 17245414 DOI: 10.1038/Nrm2106 |
0.431 |
|
| 2007 |
Tsai IC, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM. Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. International Journal of Cancer. Journal International Du Cancer. 120: 1005-12. PMID 17131344 DOI: 10.1002/Ijc.22368 |
0.641 |
|
| 2007 |
Saraf A, Virshup DM, Strack S. Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. The Journal of Biological Chemistry. 282: 573-80. PMID 17085438 DOI: 10.1074/Jbc.M607407200 |
0.402 |
|
| 2006 |
Margolis SS, Perry JA, Forester CM, Nutt LK, Guo Y, Jardim MJ, Thomenius MJ, Freel CD, Darbandi R, Ahn JH, Arroyo JD, Wang XF, Shenolikar S, Nairn AC, Dunphy WG, ... ... Virshup DM, et al. Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis. Cell. 127: 759-73. PMID 17110335 DOI: 10.1016/J.Cell.2006.10.035 |
0.492 |
|
| 2006 |
Klimowski LK, Garcia BA, Shabanowitz J, Hunt DF, Virshup DM. Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling. The Febs Journal. 273: 4594-602. PMID 16965538 DOI: 10.1111/J.1742-4658.2006.05462.X |
0.534 |
|
| 2006 |
Gallego M, Eide EJ, Woolf MF, Virshup DM, Forger DB. An opposite role for tau in circadian rhythms revealed by mathematical modeling. Proceedings of the National Academy of Sciences of the United States of America. 103: 10618-23. PMID 16818876 DOI: 10.1073/Pnas.0604511103 |
0.806 |
|
| 2006 |
Gallego M, Kang H, Virshup DM. Protein phosphatase 1 regulates the stability of the circadian protein PER2. The Biochemical Journal. 399: 169-75. PMID 16813562 DOI: 10.1042/Bj20060678 |
0.59 |
|
| 2006 |
Swiatek W, Kang H, Garcia BA, Shabanowitz J, Coombs GS, Hunt DF, Virshup DM. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. The Journal of Biological Chemistry. 281: 12233-41. PMID 16513652 DOI: 10.1074/Jbc.M510580200 |
0.525 |
|
| 2005 |
Eide EJ, Kang H, Crapo S, Gallego M, Virshup DM. Casein kinase I in the mammalian circadian clock. Methods in Enzymology. 393: 408-18. PMID 15817302 DOI: 10.1016/S0076-6879(05)93019-X |
0.833 |
|
| 2005 |
Gallego M, Virshup DM. Protein serine/threonine phosphatases: life, death, and sleeping. Current Opinion in Cell Biology. 17: 197-202. PMID 15780597 DOI: 10.1016/J.Ceb.2005.01.002 |
0.5 |
|
| 2005 |
Eide EJ, Woolf MF, Kang H, Woolf P, Hurst W, Camacho F, Vielhaber EL, Giovanni A, Virshup DM. Control of mammalian circadian rhythm by CKIε-regulated proteasome-mediated PER2 degradation Molecular and Cellular Biology. 25: 2795-2807. PMID 15767683 DOI: 10.1128/Mcb.25.7.2795-2807.2005 |
0.788 |
|
| 2005 |
Firulli BA, Krawchuk D, Centonze VE, Vargesson N, Virshup DM, Conway SJ, Cserjesi P, Laufer E, Firulli AB. Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. Nature Genetics. 37: 373-81. PMID 15735646 DOI: 10.1038/Ng1525 |
0.458 |
|
| 2004 |
Okamura H, Garcia-Rodriguez C, Martinson H, Qin J, Virshup DM, Rao A. A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Molecular and Cellular Biology. 24: 4184-95. PMID 15121840 DOI: 10.1128/Mcb.24.10.4184-4195.2004 |
0.573 |
|
| 2004 |
Firulli BA, Virshup DM, Firulli AB. Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines. Biological Procedures Online. 6: 16-22. PMID 15103396 DOI: 10.1251/Bpo69 |
0.499 |
|
| 2004 |
Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM. Regulation of casein kinase I epsilon activity by Wnt signaling. The Journal of Biological Chemistry. 279: 13011-7. PMID 14722104 DOI: 10.1074/Jbc.M304682200 |
0.703 |
|
| 2003 |
Firulli BA, Howard MJ, McDaid JR, McIlreavey L, Dionne KM, Centonze VE, Cserjesi P, Virshup DM, Firulli AB. PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. Molecular Cell. 12: 1225-37. PMID 14636580 DOI: 10.1016/S1097-2765(03)00425-8 |
0.492 |
|
| 2002 |
Liu Y, Virshup DM, White RL, Hsu LC. Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. Cancer Research. 62: 6357-61. PMID 12438214 |
0.41 |
|
| 2002 |
Liu F, Virshup DM, Nairn AC, Greengard P. Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors. The Journal of Biological Chemistry. 277: 45393-9. PMID 12223474 DOI: 10.1074/Jbc.M204499200 |
0.45 |
|
| 2002 |
Raetz EA, Perkins SL, Carlson MA, Schooler KP, Carroll WL, Virshup DM. The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas American Journal of Pathology. 161: 875-883. PMID 12213716 DOI: 10.1016/S0002-9440(10)64248-4 |
0.421 |
|
| 2002 |
Li X, Scuderi A, Letsou A, Virshup DM. B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster. Molecular and Cellular Biology. 22: 3674-84. PMID 11997504 DOI: 10.1128/Mcb.22.11.3674-3684.2002 |
0.617 |
|
| 2002 |
Eide EJ, Vielhaber EL, Hinz WA, Virshup DM. The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. The Journal of Biological Chemistry. 277: 17248-54. PMID 11875063 DOI: 10.1074/Jbc.M111466200 |
0.797 |
|
| 2002 |
Li X, Virshup DM. Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A. European Journal of Biochemistry / Febs. 269: 546-52. PMID 11856313 DOI: 10.1046/J.0014-2956.2001.02680.X |
0.527 |
|
| 2002 |
Gao ZH, Seeling JM, Hill V, Yochum A, Virshup DM. Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex. Proceedings of the National Academy of Sciences of the United States of America. 99: 1182-7. PMID 11818547 DOI: 10.1073/Pnas.032468199 |
0.445 |
|
| 2001 |
Vielhaber EL, Duricka D, Ullman KS, Virshup DM. Nuclear Export of Mammalian PERIOD Proteins Journal of Biological Chemistry. 276: 45921-45927. PMID 11591712 DOI: 10.1074/Jbc.M107726200 |
0.806 |
|
| 2001 |
Li X, Yost HJ, Virshup DM, Seeling JM. Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. The Embo Journal. 20: 4122-31. PMID 11483515 DOI: 10.1093/Emboj/20.15.4122 |
0.565 |
|
| 2001 |
Eide EJ, Virshup DM. Casein kinase I: another cog in the circadian clockworks. Chronobiology International. 18: 389-98. PMID 11475410 DOI: 10.1081/Cbi-100103963 |
0.833 |
|
| 2001 |
Vielhaber E, Virshup DM. Casein kinase I: From obscurity to center stage Iubmb Life. 51: 73-78. PMID 11463166 DOI: 10.1080/15216540117461 |
0.822 |
|
| 2001 |
Toh KL, Jones CR, He Y, Eide EJ, Hinz WA, Virshup DM, Ptácek LJ, Fu YH. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science (New York, N.Y.). 291: 1040-3. PMID 11232563 DOI: 10.1126/Science.1057499 |
0.764 |
|
| 2001 |
Camacho F, Cilio M, Guo Y, Virshup DM, Patel K, Khorkova O, Styren S, Morse B, Yao Z, Keesler GA. Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2 Febs Letters. 489: 159-165. PMID 11165242 DOI: 10.1016/S0014-5793(00)02434-0 |
0.554 |
|
| 2000 |
Vielhaber E, Eide E, Rivers A, Gao ZH, Virshup DM. Nuclear entry of the circadian regulator MPER1 is controlled by mammalian casein kinase I ε Molecular and Cellular Biology. 20: 4888-4899. PMID 10848614 DOI: 10.1128/Mcb.20.13.4888-4899.2000 |
0.833 |
|
| 2000 |
Keesler GA, Camacho F, Guo Y, Virshup D, Mondadori C, Yao Z. Phosphorylation and destabilization of human period I clock protein by human casein kinase Iε Neuroreport. 11: 951-955. PMID 10790862 DOI: 10.1097/00001756-200004070-00011 |
0.544 |
|
| 2000 |
Virshup DM. Protein phosphatase 2A: A panoply of enzymes Current Opinion in Cell Biology. 12: 180-185. PMID 10712915 DOI: 10.1016/S0955-0674(99)00074-5 |
0.38 |
|
| 2000 |
Gao ZH, Metherall J, Virshup DM. Identification of casein kinase I substrates by in vitro expression cloning screening Biochemical and Biophysical Research Communications. 268: 562-566. PMID 10679243 DOI: 10.1006/Bbrc.2000.2168 |
0.48 |
|
| 1999 |
Gietzen KF, Virshup DM. Identification of inhibitory autophosphorylation sites in casein kinase I ε Journal of Biological Chemistry. 274: 32063-32070. PMID 10542239 DOI: 10.1074/Jbc.274.45.32063 |
0.502 |
|
| 1999 |
Seeling JM, Miller JR, Gil R, Moon RT, White R, Virshup DM. Regulation of β-catenin signaling by the B56 subunit of protein phosphatase 2A Science. 283: 2089-2091. PMID 10092233 DOI: 10.1126/Science.283.5410.2089 |
0.406 |
|
| 1998 |
McCright B, Virshup DM. Identifying protein phosphatase 2A interacting proteins using the yeast two-hybrid method Methods in Molecular Biology (Clifton, N.J.). 93: 263-277. PMID 9664544 DOI: 10.1385/0-89603-468-2:263 |
0.33 |
|
| 1998 |
Rivers A, Gietzen KF, Vielhaber E, Virshup DM. Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle. The Journal of Biological Chemistry. 273: 15980-4. PMID 9632646 DOI: 10.1074/Jbc.273.26.15980 |
0.82 |
|
| 1998 |
Cegielska A, Gietzen KF, Rivers A, Virshup DM. Autoinhibition of casein kinase I ε (CKIε) is relieved by protein phosphatases and limited proteolysis Journal of Biological Chemistry. 273: 1357-1364. PMID 9430669 DOI: 10.1074/Jbc.273.3.1357 |
0.478 |
|
| 1997 |
Gietzen KJ, Virshup DM. Determinants of casein kinase i epsilon (ckir) autoinhibition Faseb Journal. 11. |
0.379 |
|
| 1996 |
McCright B, Rivers AM, Audlin S, Virshup DM. The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm Journal of Biological Chemistry. 271: 22081-22089. PMID 8703017 DOI: 10.1074/Jbc.271.36.22081 |
0.394 |
|
| 1995 |
Fish KJ, Cegielska A, Getman ME, Landes GM, Virshup DM. Isolation and characterization of human casein kinase I∈ (CKI), a novel member of the CKI gene family Journal of Biological Chemistry. 270: 14875-14883. PMID 7797465 DOI: 10.1074/Jbc.270.25.14875 |
0.423 |
|
| 1995 |
McCright B, Virshup DM. Identification of a new family of protein phosphatase 2A regulatory subunits Journal of Biological Chemistry. 270: 26123-26128. PMID 7592815 DOI: 10.1074/Jbc.270.44.26123 |
0.397 |
|
| 1994 |
Cegielska A, Moarefi I, Fanning E, Virshup DM. T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123 Journal of Virology. 68: 269-275. PMID 8254738 DOI: 10.1128/Jvi.68.1.269-275.1994 |
0.373 |
|
| 1994 |
Cegielska A, Shaffer S, Derua R, Goris J, Virshup DM. Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication Molecular and Cellular Biology. 14: 4616-4623. PMID 8007966 DOI: 10.1128/Mcb.14.7.4616 |
0.333 |
|
| 1993 |
Cegielska A, Virshup DM. Control of Simian Virus 40 DNA Replication by the HeLa Cell Nuclear Kinase Casein Kinase I Molecular and Cellular Biology. 13: 1202-1211. PMID 8380893 DOI: 10.1128/Mcb.13.2.1202 |
0.491 |
|
| 1992 |
Virshup DM, Russo AA, Kelly TJ. Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A. Molecular and Cellular Biology. 12: 4883-95. PMID 1328866 DOI: 10.1128/mcb.12.11.4883-4895.1992 |
0.313 |
|
| 1991 |
Scheidtmann KH, Virshup DM, Kelly TJ. Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity. Journal of Virology. 65: 2098-101. PMID 1848320 DOI: 10.1128/Jvi.65.4.2098-2101.1991 |
0.332 |
|
| 1989 |
Virshup DM, Kauffman MG, Kelly TJ. Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. The Embo Journal. 8: 3891-8. PMID 2555176 DOI: 10.1002/J.1460-2075.1989.Tb08568.X |
0.38 |
|
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