Wayne Jason Brouillette - Publications

Affiliations: 
University of Alabama, Birmingham, Birmingham, AL, United States 
Area:
Organic Chemistry, Pharmaceutical Chemistry
Website:
http://apps.medicine.uab.edu/FacultyDirectory/FacultyData.asp?FID=26447

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Atigadda VR, Xia G, Deshpande A, Wu L, Kedishvili N, Smith CD, Krontiras H, Bland KI, Grubbs CJ, Brouillette WJ, Muccio DD. Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers. Journal of Medicinal Chemistry. 58: 7763-74. PMID 26331194 DOI: 10.1021/acs.jmedchem.5b00829  1
2014 Atigadda VR, Xia G, Desphande A, Boerma LJ, Lobo-Ruppert S, Grubbs CJ, Smith CD, Brouillette WJ, Muccio DD. Methyl substitution of a rexinoid agonist improves potency and reveals site of lipid toxicity. Journal of Medicinal Chemistry. 57: 5370-80. PMID 24801499 DOI: 10.1021/jm5004792  1
2014 Desphande A, Xia G, Boerma LJ, Vines KK, Atigadda VR, Lobo-Ruppert S, Grubbs CJ, Moeinpour FL, Smith CD, Christov K, Brouillette WJ, Muccio DD. Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention. Bioorganic & Medicinal Chemistry. 22: 178-85. PMID 24359708 DOI: 10.1016/j.bmc.2013.11.039  1
2014 Zha C, Brown GB, Brouillette WJ. A highly predictive 3D-QSAR model for binding to the voltage-gated sodium channel: design of potent new ligands. Bioorganic & Medicinal Chemistry. 22: 95-104. PMID 24332655 DOI: 10.1016/j.bmc.2013.11.049  1
2012 Li Y, Silamkoti A, Kolavi G, Mou L, Gulati S, Air GM, Brouillette WJ. Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: the hydrophobic side chain influences type A subtype selectivity. Bioorganic & Medicinal Chemistry. 20: 4582-9. PMID 22677529 DOI: 10.1016/j.bmc.2012.05.001  1
2012 Venkatramani L, Johnson ES, Kolavi G, Air GM, Brouillette WJ, Mooers BH. Crystal structure of a new benzoic acid inhibitor of influenza neuraminidase bound with a new tilt induced by overpacking subsite C6. Bmc Structural Biology. 12: 7. PMID 22559154 DOI: 10.1186/1472-6807-12-7  1
2010 Kolesar JM, Hoel R, Pomplun M, Havighurst T, Stublaski J, Wollmer B, Krontiras H, Brouillette W, Muccio D, Kim K, Grubbs CJ, Bailey HE. A pilot, first-in-human, pharmacokinetic study of 9cUAB30 in healthy volunteers. Cancer Prevention Research (Philadelphia, Pa.). 3: 1565-70. PMID 21149332 DOI: 10.1158/1940-6207.CAPR-10-0149  1
2009 Kang S, Mou L, Lanman J, Velu S, Brouillette WJ, Prevelige PE. Synthesis of biotin-tagged chemical cross-linkers and their applications for mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 23: 1719-26. PMID 19412923 DOI: 10.1002/rcm.4066  1
2009 Moro WB, Yang Z, Kane TA, Zhou Q, Harville S, Brouillette CG, Brouillette WJ. SAR studies for a new class of antibacterial NAD biosynthesis inhibitors. Journal of Combinatorial Chemistry. 11: 617-25. PMID 19408950 DOI: 10.1021/cc9000357  1
2009 Moro WB, Yang Z, Kane TA, Brouillette CG, Brouillette WJ. Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs). Bioorganic & Medicinal Chemistry Letters. 19: 2001-5. PMID 19249205 DOI: 10.1016/j.bmcl.2009.02.034  1
2009 Jiang W, Deng W, Bailey SK, Nail CD, Frost AR, Brouillette WJ, Muccio DD, Grubbs CJ, Ruppert JM, Lobo-Ruppert SM. Prevention of KLF4-mediated tumor initiation and malignant transformation by UAB30 rexinoid. Cancer Biology & Therapy. 8: 289-98. PMID 19197145 DOI: 10.4161/cbt.8.3.7486  1
2008 Lu S, Smith CD, Yang Z, Pruett PS, Nagy L, McCombs D, Delucas LJ, Brouillette WJ, Brouillette CG. Structure of nicotinic acid mononucleotide adenylyltransferase from Bacillus anthracis. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 64: 893-8. PMID 18931430 DOI: 10.1107/S1744309108029102  1
2008 Love WK, Deangelis JT, Berletch JB, Phipps SM, Andrews LG, Brouillette WJ, Muccio DD, Tollefsbol TO. The Novel Retinoid, 9cUAB30, Inhibits Telomerase and Induces Apoptosis in HL60 Cells. Translational Oncology. 1: 148-52. PMID 18795149 DOI: 10.1593/tlo.08142  1
2007 McDonald HM, Pruett PS, Deivanayagam C, Protasevich II, Carson WM, DeLucas LJ, Brouillette WJ, Brouillette CG. Structural adaptation of an interacting non-native C-terminal helical extension revealed in the crystal structure of NAD+ synthetase from Bacillus anthracis. Acta Crystallographica. Section D, Biological Crystallography. 63: 891-905. PMID 17642516 DOI: 10.1107/S0907444907029769  1
2007 Velu SE, Mou L, Luan CH, Yang ZW, DeLucas LJ, Brouillette CG, Brouillette WJ. Antibacterial nicotinamide adenine dinucleotide synthetase inhibitors: amide- and ether-linked tethered dimers with alpha-amino acid end groups. Journal of Medicinal Chemistry. 50: 2612-21. PMID 17489580 DOI: 10.1021/jm061349l  1
2007 Gorman GS, Coward L, Kerstner-Wood C, Cork L, Kapetanovic IM, Brouillette WJ, Muccio DD. In vitro metabolic characterization, phenotyping, and kinetic studies of 9cUAB30, a retinoid X receptor-specific retinoid. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 35: 1157-64. PMID 17446266 DOI: 10.1124/dmd.106.013938  1
2006 Grubbs CJ, Lubet RA, Atigadda VR, Christov K, Deshpande AM, Tirmal V, Xia G, Bland KI, Eto I, Brouillette WJ, Muccio DD. Efficacy of new retinoids in the prevention of mammary cancers and correlations with short-term biomarkers. Carcinogenesis. 27: 1232-9. PMID 16344269 DOI: 10.1093/carcin/bgi308  1
2005 Velu SE, Luan CH, Delucas LJ, Brouillette CG, Brouillette WJ. Tethered dimer inhibitors of NAD synthetase: parallel synthesis of an aryl-substituted SAR library. Journal of Combinatorial Chemistry. 7: 898-904. PMID 16283799 DOI: 10.1021/cc050063j  1
2004 Zha C, Brown GB, Brouillette WJ. Synthesis and structure-activity relationship studies for hydantoins and analogues as voltage-gated sodium channel ligands. Journal of Medicinal Chemistry. 47: 6519-28. PMID 15588087 DOI: 10.1021/jm040077o  1
2004 Lommer BS, Ali SM, Bajpai SN, Brouillette WJ, Air GM, Luo M. A benzoic acid inhibitor induces a novel conformational change in the active site of Influenza B virus neuraminidase. Acta Crystallographica. Section D, Biological Crystallography. 60: 1017-23. PMID 15159560 DOI: 10.1107/S0907444904006225  1
2004 Yang ZW, Tendian SW, Carson WM, Brouillette WJ, Delucas LJ, Brouillette CG. Dimethyl sulfoxide at 2.5% (v/v) alters the structural cooperativity and unfolding mechanism of dimeric bacterial NAD+ synthetase. Protein Science : a Publication of the Protein Society. 13: 830-41. PMID 14978314 DOI: 10.1110/ps.03330104  1
2003 Grubbs CJ, Hill DL, Bland KI, Beenken SW, Lin TH, Eto I, Atigadda VR, Vines KK, Brouillette WJ, Muccio DD. 9cUAB30, an RXR specific retinoid, and/or tamoxifen in the prevention of methylnitrosourea-induced mammary cancers. Cancer Letters. 201: 17-24. PMID 14580682 DOI: 10.1016/S0304-3835(03)00461-0  1
2003 Atigadda VR, Vines KK, Grubbs CJ, Hill DL, Beenken SL, Bland KI, Brouillette WJ, Muccio DD. Conformationally defined retinoic acid analogues. 5. Large-scale synthesis and mammary cancer chemopreventive activity for (2E,4E,6Z,8E)-8-(3',4'-dihydro-1'(2'H)-naphthalen-1'-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid (9cUAB30). Journal of Medicinal Chemistry. 46: 3766-9. PMID 12904083 DOI: 10.1021/jm030095q  1
2003 Velu SE, Cristofoli WA, Garcia GJ, Brouillette CG, Pierson MC, Luan CH, DeLucas LJ, Brouillette WJ. Tethered dimers as NAD synthetase inhibitors with antibacterial activity. Journal of Medicinal Chemistry. 46: 3371-81. PMID 12852767 DOI: 10.1021/jm030003x  1
2003 Brouillette WJ, Bajpai SN, Ali SM, Velu SE, Atigadda VR, Lommer BS, Finley JB, Luo M, Air GM. Pyrrolidinobenzoic acid inhibitors of influenza virus neuraminidase: modifications of essential pyrrolidinone ring substituents. Bioorganic & Medicinal Chemistry. 11: 2739-49. PMID 12788348 DOI: 10.1016/S0968-0896(03)00271-2  1
1999 Atigadda VR, Brouillette WJ, Duarte F, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Sudbeck E, Finley J, Air GM, Luo M, Laver GW. Hydrophobic benzoic acids as inhibitors of influenza neuraminidase. Bioorganic & Medicinal Chemistry. 7: 2487-97. PMID 10632058 DOI: 10.1016/S0968-0896(99)00197-2  1
1999 Finley JB, Atigadda VR, Duarte F, Zhao JJ, Brouillette WJ, Air GM, Luo M. Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water molecules in the active site. Journal of Molecular Biology. 293: 1107-19. PMID 10547289 DOI: 10.1006/jmbi.1999.3180  1
1999 Hutchison TL, Saeed A, Wolkowicz PE, McMillin JB, Brouillette WJ. Stereoselective synthesis of a conformationally defined cyclohexyl carnitine analogue that binds CPT-1 with high affinity Bioorganic and Medicinal Chemistry. 7: 1505-1511. PMID 10482442 DOI: 10.1016/S0968-0896(99)00080-2  1
1999 Haddox JL, Pfister RR, Muccio DD, Villain M, Sommers CI, Chaddha M, Anantharamaiah GM, Brouillette WJ, DeLucas LJ. Bioactivity of peptide analogs of the neutrophil chemoattractant, N- acetyl-proline-glycine-proline Investigative Ophthalmology and Visual Science. 40: 2427-2429. PMID 10476813  1
1999 Brouillette WJ, Atigadda VR, Luo M, Air GM, Babu YS, Bantia S. Design of benzoic acid inhibitors of influenza neuraminidase containing a cyclic substitution for the N-acetyl grouping. Bioorganic & Medicinal Chemistry Letters. 9: 1901-6. PMID 10450950 DOI: 10.1016/S0960-894X(99)00318-2  1
1999 Atigadda VR, Brouillette WJ, Duarte F, Ali SM, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Sudbeck EA, Finley J, Luo M, Air GM, Laver GW. Potent inhibition of influenza sialidase by a benzoic acid containing a 2-pyrrolidinone substituent. Journal of Medicinal Chemistry. 42: 2332-43. PMID 10395473 DOI: 10.1021/jm980707k  1
1999 Brown ML, Zha CC, Van Dyke CC, Brown GB, Brouillette WJ. Comparative molecular field analysis of hydantoin binding to the neuronal voltage-dependent sodium channel Journal of Medicinal Chemistry. 42: 1537-1545. PMID 10229624 DOI: 10.1021/jm980556l  1
1999 Muccio DD, Lee YC, Alam M, Brouillette WJ. 1H and 13C NMR assignments of conformationally defined 6-s-cis-retinoids Magnetic Resonance in Chemistry. 37: 82-85.  1
1998 Hutchison TL, Brouillette WJ. Synthesis of 2-[6-(2,4-Dinitrophenoxy)hexyl]oxiranecarboxylic acid: A selective carnitine palmitoyltransferase-1 inhibitor Bioorganic and Medicinal Chemistry. 6: 2133-2138. PMID 9881103 DOI: 10.1016/S0968-0896(98)00175-8  1
1998 Muccio DD, Brouillette WJ, Breitman TR, Taimi M, Emanuel PD, Zhang X, Chen G, Sani BP, Venepally P, Reddy L, Alam M, Simpson-Herren L, Hill DL. Conformationally defined retinoic acid analogues. 4. Potential new agents for acute promyelocytic and juvenile myelomonocytic leukemias. Journal of Medicinal Chemistry. 41: 1679-87. PMID 9572893 DOI: 10.1021/jm970635h  1
1997 Shimada T, Ross AC, Muccio DD, Brouillette WJ, Shealy YF. Regulation of hepatic lecithin:retinol acyltransferase activity by retinoic acid receptor-selective retinoids Archives of Biochemistry and Biophysics. 344: 220-227. PMID 9244401 DOI: 10.1006/abbi.1997.0209  1
1997 Luo M, Air GM, Brouillette WJ. Design of aromatic inhibitors of influenza virus neuraminidase Journal of Infectious Diseases. 176. PMID 9240697  1
1997 Sudbeck EA, Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Laver WG, Babu YS, Bantia S, Chand P, Chu N, Montgomery JA, Walsh DA, Luo M. Guanidinobenzoic acid inhibitors of influenza virus neuraminidase. Journal of Molecular Biology. 267: 584-94. PMID 9126840 DOI: 10.1006/jmbi.1996.0885  1
1997 Brown ML, Brown GB, Brouillette WJ. Effects of log P and phenyl ring conformation on the binding of 5- phenylhydantoins to the voltage-dependent sodium channel Journal of Medicinal Chemistry. 40: 602-607. PMID 9046351 DOI: 10.1021/jm960692v  1
1997 Lake CH, Alam M, Muccio DD, Brouillette WJ. A structural model for a new class of conformationally constrained retinoid: (2Z,4E)-4-[3',4'-dihydro-1'(2'H)-naphthalene-1'-ylidene]-2-butenoic acid Journal of Chemical Crystallography. 27: 231-235.  1
1996 Muccio DD, Brouillette WJ, Alam M, Vaezi MF, Sani BP, Venepally P, Reddy L, Li E, Norris AW, Simpson-Herren L, Hill DL. Conformationally defined 6-s-trans-retinoic acid analogs. 3. Structure-activity relationships for nuclear receptor binding, transcriptional activity, and cancer chemopreventive activity. Journal of Medicinal Chemistry. 39: 3625-35. PMID 8809153 DOI: 10.1021/jm9603126  1
1996 Lin TH, Rogers TS, Hill DL, Simpson-Herren L, Farnell DR, Kochhar DM, Alam M, Brouillette WJ, Muccio DD. Murine toxicology and pharmacology of UAB-8, a conformationally constrained analog of retinoic acid. Toxicology and Applied Pharmacology. 139: 310-6. PMID 8806847 DOI: 10.1006/taap.1996.0170  1
1995 Jedrzejas MJ, Singh S, Brouillette WJ, Air GM, Luo M. A strategy for theoretical binding constant, Ki, calculations for neuraminidase aromatic inhibitors designed on the basis of the active site structure of influenza virus neuraminidase. Proteins. 23: 264-77. PMID 8592707 DOI: 10.1002/prot.340230215  1
1995 Jedrzejas MJ, Singh S, Brouillette WJ, Laver WG, Air GM, Luo M. Structures of aromatic inhibitors of influenza virus neuraminidase. Biochemistry. 34: 3144-51. PMID 7880809  1
1995 Brouillette WJ, Gray GM, Saeed A. Conformationally defined cyclohexyl carnitine analogs Acta Crystallographica, Section C: Crystal Structure Communications. 51. PMID 7794567  1
1995 Singh S, Jedrzejas MJ, Air GM, Luo M, Laver WG, Brouillette WJ. Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction. Journal of Medicinal Chemistry. 38: 3217-25. PMID 7650674  1
1995 Alam M, Zhestkov V, Sani BP, Venepally P, Levin AA, Kazmer S, Li E, Norris AW, Zhang XK, Lee MO, Hill DL, Lin TH, Brouillette WJ, Muccio DD. Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity Journal of Medicinal Chemistry. 38: 2302-2310. PMID 7608895  1
1995 Jedrzejas MJ, Luo M, Singh S, Brouillette WJ, Air GM. 4-(Acetylamino)-3-hydroxy-5-nitrobenzoic acid. Acta Crystallographica. Section C, Crystal Structure Communications. 51: 1910-2. PMID 7576370  1
1995 Robinson CY, Waterhous DV, Muccio DD, Brouillette WJ. Conformationally constrained precursors to retinoic acid analogs which stabilize the 9Z-configuration Bioorganic and Medicinal Chemistry Letters. 5: 953-958. DOI: 10.1016/0960-894X(95)00151-I  1
1994 Brouillette WJ, Jestkov VP, Brown ML, Akhtar MS, DeLorey TM, Brown GB. Bicyclic hydantoins with a bridgehead nitrogen. Comparison of anticonvulsant activities with binding to the neuronal voltage-dependent sodium channel. Journal of Medicinal Chemistry. 37: 3289-93. PMID 7932556  1
1994 Saeed A, McMillin JB, Wolkowicz PE, Brouillette WJ. 3-Amino-5,5-dimethylhexanoic acid. Synthesis, resolution, and effects on carnitine acyltransferases. Journal of Medicinal Chemistry. 37: 3247-51. PMID 7932552  1
1994 Vaezi MF, Alam M, Sani BP, Rogers TS, Simpson-Herren L, Wille JJ, Hill DL, Doran TI, Brouillette WJ, Muccio DD. A conformationally defined 6-s-trans-retinoic acid isomer: synthesis, chemopreventive activity, and toxicity. Journal of Medicinal Chemistry. 37: 4499-507. PMID 7799400  1
1994 Brouillette WJ, Saeed A, Abuelyaman A, Hutchison TL, Wolkowicz PE, McMillin JB. Synthesis and enzymatic evaluation of conformationally defined carnitine analogs Journal of Organic Chemistry. 59: 4297-4303.  1
1993 Saeed A, McMillin JB, Wolkowicz PE, Brouillette WJ. Carnitine acyltransferase enzymic catalysis requires a positive charge on the carnitine cofactor. Archives of Biochemistry and Biophysics. 305: 307-12. PMID 8373168 DOI: 10.1006/abbi.1993.1427  1
1993 Brouillette WJ, Puckett SW, Comber RN, Hosmer CA. Effects of C-methylated carnitine analogs on rates of mitochondrial fatty acid oxidation Biochemical Pharmacology. 46: 1671-1673. PMID 8240425 DOI: 10.1016/0006-2952(93)90339-X  1
1993 Brouillette WJ, Abuelyaman AS, Hosmer CA, Comber RN, Saeed A. Preparation of the racemate and enantiomers of 3-hydroxy-5,5-dimethylhexanoic acid Organic Preparations and Procedures International. 25: 243-246. DOI: 10.1080/00304949309457956  1
1990 Brouillette WJ, Brown GB, DeLorey TM, Liang G. Sodium channel binding and anticonvulsant activities of hydantoins containing conformationally constrained 5-phenyl substituents. Journal of Pharmaceutical Sciences. 79: 871-4. PMID 2177789  1
1990 Akhtar MS, Brouillette WJ, Waterhous DV. Bicyclic imides with bridgehead nitrogen. Synthesis of an anti-Bredt bicyclic hydantoin Journal of Organic Chemistry. 55: 5222-5225.  1
1989 Brouillette WJ, Grunewald GL, Brown GB, DeLorey TM, Akhtar MS, Liang G. Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models. Journal of Medicinal Chemistry. 32: 1577-80. PMID 2544727  1
1989 Robinson CY, Brouillette WJ, Muccio DD. Reactions of vinylogous phosphonate carbanions and Reformatsky reagents with a sterically hindered ketone and enone Journal of Organic Chemistry. 54: 1992-1997.  1
1988 Brouillette WJ, Brown GB, DeLorey TM, Shirali SS, Grunewald GL. Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel. Journal of Medicinal Chemistry. 31: 2218-21. PMID 2846842  1
1988 Comber RN, Brouillette WJ. Assignment of absolute configurations for 4-methylcarnitine stereoisomers by proton nuclear magnetic resonance Journal of Organic Chemistry. 53: 1121-1122.  1
1987 Vaezi MF, Robinson CY, Hope KD, Brouillette WJ, Muccio DD. Preparation of the 9-cis, 13-cis-, and all trans-isomers of α- and β2-retinal Organic Preparations and Procedures International. 19: 187-195. DOI: 10.1080/00304948709356186  1
1987 Comber RN, Brouillette WJ. Syntheses of the enantiomers of carnitine and 4-methylcarnitine via the chromatographic resolution of γ-(dimethylamino)-β-hydroxy ester precursors Journal of Organic Chemistry. 52: 2311-2314.  1
1985 Comber RN, Brouillette WJ. An efficient synthesis of d, l-carnitine hydrochloride via the acylation of an α-aminoketone Organic Preparations and Procedures International. 17: 175-181. DOI: 10.1080/00304948509355495  1
1985 Comber RN, Hosmer CA, Brouillette WJ. Syntheses of α-, β-, and γ-substituted carnitines via β-keto esters Journal of Organic Chemistry. 50: 3627-3631.  1
1984 Brouillette WJ, Grunewald GL. Synthesis and anticonvulsant activity of some substituted lactams and amides. Journal of Medicinal Chemistry. 27: 202-6. PMID 6694169  1
1984 Brouillette WJ, Einspahr HM. Bicyclic imides with bridgehead nitrogen. Synthesis and X-ray crystal structure of a bicyclic 2,4-oxazolidinedione Journal of Organic Chemistry. 49: 5113-5116.  1
1984 Brouillette WJ, Friedrich JD, Muccio DD. Synthesis and carbon-13 NMR of an unusual tricyclic barbituric acid derivative Journal of Organic Chemistry. 49: 3227-3230.  1
1980 Grunewald GL, Brouillette WJ, Finney JA. Synthesis of α-hydroxyamides via the cyanosilylation of aromatic ketones Tetrahedron Letters. 21: 1219-1220. DOI: 10.1016/S0040-4039(00)71375-X  1
1979 Brouillette WJ, Smissman EE, Grunewald GL. N-acylcarbamates as intermediates in synthetic approaches to a bicyclic trimethylene-bridged 2,4-oxazolidinedione and hydantoin Journal of Organic Chemistry. 44: 839-843.  1
1978 Grunewald GL, Brouillette WJ. An ethoxycarbonyl migration from an amide nitrogen to oxygen Journal of Organic Chemistry. 43: 1839-1841.  1
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