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K. Barry Sharpless - Publications

Affiliations: 
Massachusetts Institute of Technology, Cambridge, MA, United States 
 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Click chemistry
Website:
http://www.nobelprize.org/nobel_prizes/chemistry/laureates/2001/sharpless-bio.html

217 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Zheng Q, Woehl JL, Kitamura S, Santos-Martins D, Smedley CJ, Li G, Forli S, Moses JE, Wolan DW, Sharpless KB. SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase. Proceedings of the National Academy of Sciences of the United States of America. PMID 31484779 DOI: 10.1073/pnas.1909972116  1
2019 Taylor P, Yan-Jye S, Momper J, Hou W, Camacho-Hernandez GA, Radic Z, Rosenberg Y, Kovarik Z, Sit R, Sharpless KB. Assessment of ionizable, zwitterionic oximes as reactivating antidotal agents for organophosphate exposure. Chemico-Biological Interactions. PMID 31100277 DOI: 10.1016/j.cbi.2019.05.015  0.8
2019 Liu F, Wang H, Li S, Bare GAL, Chen X, Wang C, Moses JE, Wu P, Sharpless KB. Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4) Derived Connective Hubs For Bioconjugation to DNA and Proteins. Angewandte Chemie (International Ed. in English). PMID 30998840 DOI: 10.1002/anie.201902489  0.92
2019 Hong S, Shi Y, Wu NC, Grande G, Douthit L, Wang H, Zhou W, Sharpless KB, Wilson IA, Xie J, Wu P. Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification. Nature Communications. 10: 1799. PMID 30996301 DOI: 10.1038/s41467-019-09608-w  0.92
2019 Kovarik Z, Hrvat NM, Kalisiak J, Katalinić M, Sit RK, Zorbaz T, Radić Z, Fokin VV, Sharpless KB, Taylor P. Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase. Toxicology and Applied Pharmacology. PMID 30978400 DOI: 10.1016/j.taap.2019.04.007  1
2019 Smedley CJ, Zheng Q, Gao B, Li S, Molino A, Duivenvoorden HM, Parker BS, Wilson DJD, Sharpless KB, Moses JE. Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides. Angewandte Chemie (International Ed. in English). PMID 30740848 DOI: 10.1002/anie.201813761  0.96
2018 Kovarik Z, Kalisiak J, Hrvat NM, Katalinić M, Zorbaz T, Žunec S, Green C, Radić Z, Fokin VV, Sharpless KB, Taylor P. Reversal of tabun toxicity, enabled by a triazole annulated oxime library-reactivators of acetylcholinesterase. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30458057 DOI: 10.1002/chem.201805051  1
2018 Sit R, Kovarik Z, Macek-Hrvat N, Zunec S, Green C, Fokin V, Sharpless KB, Radic' Z, Taylor P. Pharmacology, pharmacokinetics and tissue disposition of zwitterionic hydoxyiminoacetamido alkylamines as reactivating antidotes for organophosphate exposure. The Journal of Pharmacology and Experimental Therapeutics. PMID 30190337 DOI: 10.1124/jpet.118.249383  0.8
2018 Gahtory D, Sen R, Pujari S, Li S, Zheng Q, Moses JE, Sharpless KB, Zuilhof H. Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 29949211 DOI: 10.1002/chem.201802356  0.96
2018 Liu Z, Li J, Li S, Li G, Sharpless KB, Wu P. SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization. Journal of the American Chemical Society. PMID 29451783 DOI: 10.1021/jacs.7b12788  1
2018 Sharpless KB, Gao B, Li S, Wu P, Moses JE. SuFEx Chemistry of Thionyl Tetrafluoride (SOF4) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides and Sulfonimidates. Angewandte Chemie (International Ed. in English). PMID 29314580 DOI: 10.1002/anie.201712145  0.92
2017 Guo T, Meng G, Zhan X, Yang Q, Ma T, Xu L, Sharpless KB, Dong J. A New Portal to SuFEx Click Chemistry: a Stable Fluorosulfuryl Imidazolium Salt Emerging as an "F-SO2+" Donor of Unprecedented Reactivity, Selectivity, and Scope. Angewandte Chemie (International Ed. in English). PMID 29276888 DOI: 10.1002/anie.201712429  0.96
2017 Mortenson DE, Brighty GJ, Plate L, Bare G, Chen W, Li S, Wang H, Cravatt BF, Forli S, Powers ET, Sharpless KB, Wilson IA, Kelly JW. "Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society. PMID 29265822 DOI: 10.1021/jacs.7b08366  0.92
2017 Gao B, Zhang L, Zheng Q, Zhou F, Klivansky LM, Lu J, Liu Y, Dong J, Wu P, Sharpless KB. Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates. Nature Chemistry. 9: 1083-1088. PMID 29064495 DOI: 10.1038/nchem.2796  0.96
2017 Wang H, Zhou F, Ren G, Zheng Q, Chen H, Gao B, Klivansky L, Liu Y, Wu B, Xu Q, Lu J, Sharpless KB, Wu P. SuFEx-Based Polysulfonate Formation from Ethenesulfonyl Fluoride-Amine Adducts. Angewandte Chemie (International Ed. in English). PMID 28792119 DOI: 10.1002/anie.201701160  0.96
2017 Kim WJ, Korthals K, Li S, Le C, Kalisiak J, Sharpless KB, Fokin VV, Miyamoto Y, Eckmann L. Click chemistry-facilitated structural diversification of nitrothiazoles, nitrofurans and nitropyrroles enhances antimicrobial activity against Giardia lamblia. Antimicrobial Agents and Chemotherapy. PMID 28396548 DOI: 10.1128/AAC.02397-16  1
2017 Zha GF, Zheng Q, Leng J, Wu P, Qin HL, Sharpless KB. Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides. Angewandte Chemie (International Ed. in English). PMID 28370917 DOI: 10.1002/anie.201701162  0.96
2017 Li S, Wu P, Moses JE, Sharpless KB. Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub. Angewandte Chemie (International Ed. in English). PMID 28165188 DOI: 10.1002/anie.201611048  0.92
2016 Zheng Q, Dong J, Sharpless KB. Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation. The Journal of Organic Chemistry. PMID 27764941 DOI: 10.1021/acs.joc.6b01423  0.96
2016 Qin HL, Zheng Q, Bare GA, Wu P, Sharpless KB. A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry. Angewandte Chemie (International Ed. in English). PMID 27723200 DOI: 10.1002/anie.201608807  0.96
2016 Chen W, Dong J, Plate L, Mortenson DE, Brighty GJ, Li S, Liu Y, Galmozzi A, Lee PS, Hulce JJ, Cravatt BF, Saez E, Powers ET, Wilson IA, Sharpless KB, et al. Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding-site Tyr Residue. Journal of the American Chemical Society. PMID 27191344 DOI: 10.1021/jacs.6b02960  0.92
2016 Zhang E, Tang J, Li S, Wu P, Moses JE, Sharpless KB. Chemoselective Synthesis of Polysubstituted Pyridines from Heteroaryl Fluorosulfates. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26990693 DOI: 10.1002/chem.201600167  0.92
2016 Bourne Y, Sharpless KB, Taylor P, Marchot P. Steric and dynamic parameters influencing in situ cycloadditions to form triazole inhibitors with crystalline acetylcholinesterase. Journal of the American Chemical Society. PMID 26731630 DOI: 10.1021/jacs.5b11384  1
2015 Chen W, Dong J, Li S, Liu Y, Wang Y, Yoon L, Wu P, Sharpless KB, Kelly JW. Synthesis of Sulfotyrosine-Containing Peptides by Incorporating Fluorosulfated Tyrosine Using an Fmoc-Based Solid-Phase Strategy. Angewandte Chemie (International Ed. in English). PMID 26696445 DOI: 10.1002/anie.201509016  0.92
2015 Baranczak A, Liu Y, Connelly S, Du WG, Greiner ER, Genereux JC, Wiseman RL, Eisele YS, Bradbury NC, Dong J, Noodleman L, Sharpless KB, Wilson IA, Encalada SE, Kelly JW. A Fluorogenic Aryl Fluorosulfate for Intraorganellar Transthyretin Imaging in Living Cells and in Caenorhabditis elegans. Journal of the American Chemical Society. 137: 7404-14. PMID 26051248 DOI: 10.1021/jacs.5b03042  1
2015 Liang Q, Xing P, Huang Z, Dong J, Sharpless KB, Li X, Jiang B. Palladium-catalyzed, ligand-free Suzuki reaction in water using aryl fluorosulfates. Organic Letters. 17: 1942-5. PMID 25856416 DOI: 10.1021/acs.orglett.5b00654  1
2015 Sharpless KB, Finn MG, Martín VS. Tsutomu Katsuki (1946-2014). Angewandte Chemie (International Ed. in English). 54: 4708. PMID 25766459 DOI: 10.1002/anie.201501065  1
2015 Schantz MM, Benner BA, Heckert NA, Sander LC, Sharpless KE, Vander Pol SS, Vasquez Y, Villegas M, Wise SA, Alwis KU, Blount BC, Calafat AM, Li Z, Silva MJ, Ye X, et al. Development of urine standard reference materials for metabolites of organic chemicals including polycyclic aromatic hydrocarbons, phthalates, phenols, parabens, and volatile organic compounds. Analytical and Bioanalytical Chemistry. 407: 2945-54. PMID 25651899 DOI: 10.1007/s00216-014-8441-0  0.36
2015 Templeton DW, Wolfrum EJ, Yen JH, Sharpless KE. Compositional Analysis of Biomass Reference Materials: Results from an Interlaboratory Study Bioenergy Research. DOI: 10.1007/s12155-015-9675-1  0.36
2015 Sharpless KB. Building blocks for SuFEx, the next click reaction Aldrichimica Acta. 48: 41.  1
2014 Dong J, Krasnova L, Finn MG, Sharpless KB. Sulfur(VI) fluoride exchange (SuFEx): another good reaction for click chemistry. Angewandte Chemie (International Ed. in English). 53: 9430-48. PMID 25112519 DOI: 10.1002/anie.201309399  0.84
2014 Dong J, Sharpless KB, Kwisnek L, Oakdale JS, Fokin VV. SuFEx-based synthesis of polysulfates. Angewandte Chemie (International Ed. in English). 53: 9466-70. PMID 25100330 DOI: 10.1002/anie.201403758  1
2014 Sit RK, Fokin VV, Amitai G, Sharpless KB, Taylor P, Radić Z. Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. Journal of Medicinal Chemistry. 57: 1378-89. PMID 24571195 DOI: 10.1021/jm401650z  1
2013 Turk GC, Sharpless KE, Cleveland D, Jongsma C, Mackey EA, Marlow AF, Oflaz R, Paul RL, Sieber JR, Thompson RQ, Wood LJ, Yu LL, Zeisler R, Wise SA, Yen JH, et al. Certification of elements in and use of standard reference material 3280 multivitamin/multielement tablets. Journal of Aoac International. 96: 1281-7. PMID 24645505 DOI: 10.5740/jaoacint.13-135  0.36
2013 Phinney KW, Ballihaut G, Bedner M, Benford BS, Camara JE, Christopher SJ, Davis WC, Dodder NG, Eppe G, Lang BE, Long SE, Lowenthal MS, McGaw EA, Murphy KE, Nelson BC, ... ... Sharpless KE, et al. Development of a Standard Reference Material for metabolomics research. Analytical Chemistry. 85: 11732-8. PMID 24187941 DOI: 10.1021/ac402689t  0.36
2013 Miyamoto Y, Kalisiak J, Korthals K, Lauwaet T, Cheung DY, Lozano R, Cobo ER, Upcroft P, Upcroft JA, Berg DE, Gillin FD, Fokin VV, Sharpless KB, Eckmann L. Expanded therapeutic potential in activity space of next-generation 5-nitroimidazole antimicrobials with broad structural diversity. Proceedings of the National Academy of Sciences of the United States of America. 110: 17564-9. PMID 24101497 DOI: 10.1073/pnas.1302664110  1
2013 Hirose T, Maita N, Gouda H, Koseki J, Yamamoto T, Sugawara A, Nakano H, Hirono S, Shiomi K, Watanabe T, Taniguchi H, Sharpless KB, Omura S, Sunazuka T. Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 110: 15892-7. PMID 24043811 DOI: 10.1073/pnas.1315049110  1
2013 Rimmer CA, Sharpless KE, Wise SA, Betz JM, Coates PM. Standard reference materials for dietary supplement analysis Analytical and Bioanalytical Chemistry. 405: 4337-4344. PMID 23575912 DOI: 10.1007/s00216-013-6942-x  0.36
2013 Sander LC, Bedner M, Duewer DL, Lippa KA, Phillips MM, Phinney KW, Rimmer CA, Schantz MM, Sharpless KE, Tai SS, Thomas JB, Wise SA, Wood LJ, Betz JM, Coates PM. The development and implementation of quality assurance programs to support nutritional measurements. Analytical and Bioanalytical Chemistry. 405: 4437-41. PMID 23552970 DOI: 10.1007/s00216-013-6864-7  0.36
2013 Thomas JB, Yen JH, Sharpless KE. Characterization of NIST food-matrix Standard Reference Materials for their vitamin C content. Analytical and Bioanalytical Chemistry. 405: 4539-48. PMID 23529413 DOI: 10.1007/s00216-013-6891-4  0.36
2013 Phillips MM, Sharpless KE, Wise SA. Standard reference materials for food analysis. Analytical and Bioanalytical Chemistry. 405: 4325-35. PMID 23515610 DOI: 10.1007/s00216-013-6890-5  0.36
2013 Morris GM, Green LG, Radić Z, Taylor P, Sharpless KB, Olson AJ, Grynszpan F. Automated docking with protein flexibility in the design of femtomolar "click chemistry" inhibitors of acetylcholinesterase. Journal of Chemical Information and Modeling. 53: 898-906. PMID 23451944 DOI: 10.1021/ci300545a  1
2013 Schantz MM, Sander LC, Sharpless KE, Wise SA, Yen JH, NguyenPho A, Betz JM. Development of botanical and fish oil standard reference materials for fatty acids. Analytical and Bioanalytical Chemistry. 405: 4531-8. PMID 23371533 DOI: 10.1007/s00216-013-6747-y  0.36
2013 Grimster NP, Connelly S, Baranczak A, Dong J, Krasnova LB, Sharpless KB, Powers ET, Wilson IA, Kelly JW. Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate. Journal of the American Chemical Society. 135: 5656-68. PMID 23350654 DOI: 10.1021/ja311729d  1
2013 Schantz MM, Eppe G, Focant JF, Hamilton C, Heckert NA, Heltsley RM, Hoover D, Keller JM, Leigh SD, Patterson DG, Pintar AL, Sharpless KE, Sjödin A, Turner WE, Vander Pol SS, et al. Milk and serum standard reference materials for monitoring organic contaminants in human samples. Analytical and Bioanalytical Chemistry. 405: 1203-11. PMID 23132544 DOI: 10.1007/s00216-012-6524-3  0.36
2013 Fraser BH, Hamilton S, Krause-Heuer AM, Wright PJ, Greguric I, Tucker SP, Draffan AG, Fokin VV, Sharpless KB. Synthesis of 1,4-triazole linked zanamivir dimers as highly potent inhibitors of influenza A and B Medchemcomm. 4: 383-386. DOI: 10.1039/c2md20300f  1
2012 Yamauchi JG, Gomez K, Grimster N, Dufouil M, Nemecz A, Fotsing JR, Ho KY, Talley TT, Sharpless KB, Fokin VV, Taylor P. Synthesis of selective agonists for the α7 nicotinic acetylcholine receptor with in situ click-chemistry on acetylcholine-binding protein templates. Molecular Pharmacology. 82: 687-99. PMID 22784805 DOI: 10.1124/mol.112.080291  1
2012 Rimmer CA, Putzbach K, Sharpless KE, Sander LC, Yen JH. Preparation and certification of standard reference material 3278 tocopherols in edible oils. Journal of Agricultural and Food Chemistry. 60: 6794-8. PMID 22686411 DOI: 10.1021/jf2051619  0.36
2012 Grimster NP, Stump B, Fotsing JR, Weide T, Talley TT, Yamauchi JG, Nemecz Á, Kim C, Ho KY, Sharpless KB, Taylor P, Fokin VV. Generation of candidate ligands for nicotinic acetylcholine receptors via in situ click chemistry with a soluble acetylcholine binding protein template. Journal of the American Chemical Society. 134: 6732-40. PMID 22394239 DOI: 10.1021/ja3001858  1
2012 Radi? Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radi? B, Fokin VV, Sharpless KB, Taylor P. Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases. The Journal of Biological Chemistry. 287: 11798-809. PMID 22343626 DOI: 10.1074/jbc.M111.333732  1
2012 Phinney KW, Bedner M, Tai SS, Vamathevan VV, Sander LC, Sharpless KE, Wise SA, Yen JH, Schleicher RL, Chaudhary-Webb M, Pfeiffer CM, Betz JM, Coates PM, Picciano MF. Development and certification of a standard reference material for vitamin D metabolites in human serum. Analytical Chemistry. 84: 956-62. PMID 22141317 DOI: 10.1021/ac202047n  0.36
2012 Sander LC, Bedner M, Tims MC, Yen JH, Duewer DL, Porter B, Christopher SJ, Day RD, Long SE, Molloy JL, Murphy KE, Lang BE, Lieberman R, Wood LJ, Payne MJ, ... ... Sharpless KE, et al. Development and certification of green tea-containing standard reference materials. Analytical and Bioanalytical Chemistry. 402: 473-87. PMID 22127575 DOI: 10.1007/s00216-011-5472-7  0.36
2012 Thomas JB, Duewer DL, Mugenya IO, Phinney KW, Sander LC, Sharpless KE, Sniegoski LT, Tai SS, Welch MJ, Yen JH. Preparation and value assignment of standard reference material 968e fat-soluble vitamins, carotenoids, and cholesterol in human serum. Analytical and Bioanalytical Chemistry. 402: 749-62. PMID 22015475 DOI: 10.1007/s00216-011-5447-8  0.36
2012 Radi? Z, Sit RK, Kovarik Z, Berend S, Garcia E, Zhang L, Amitai G, Green C, Radi? B, Fokin VV, Sharpless KB, Taylor P. Refinement of structural leads for centrally acting oxime reactivators of phosphylated cholinesterases (Journal of Biological Chemistry (2012) 287, (11798-11809)) Journal of Biological Chemistry. 287: 19337. DOI: 10.1074/jbc.A111.333732  1
2012 Finn MG, Sharpless KB. On the Mechanism of Asymmetric Epoxidation with Titanium-Tartrate Catalysts Asymmetric Synthesis. 247-308. DOI: 10.1016/B978-0-08-092493-9.50013-X  1
2011 Millward SW, Henning RK, Kwong GA, Pitram S, Agnew HD, Deyle KM, Nag A, Hein J, Lee SS, Lim J, Pfeilsticker JA, Sharpless KB, Heath JR. Iterative in situ click chemistry assembles a branched capture agent and allosteric inhibitor for Akt1. Journal of the American Chemical Society. 133: 18280-8. PMID 21962254 DOI: 10.1021/ja2064389  1
2011 Thomas JB, Sharpless KE, Yen JH, Rimmer CA. Determination of fat-soluble vitamins and carotenoids in standard reference material 3280 multivitamin/multielement tablets by liquid chromatography with absorbance detection. Journal of Aoac International. 94: 815-22. PMID 21797009  0.36
2011 Phillips MM, Rimmer CA, Wood LJ, Lippa KA, Sharpless KE, Duewer DL, Sander LC, Betz JM. Dietary supplement laboratory quality assurance program: the first five exercises. Journal of Aoac International. 94: 803-14. PMID 21797008  0.36
2011 Cochran R, Kalisiak J, Küçükkilinç T, Radic Z, Garcia E, Zhang L, Ho KY, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging. The Journal of Biological Chemistry. 286: 29718-24. PMID 21730071 DOI: 10.1074/jbc.M111.264739  1
2011 Wood LJ, Sharpless KE, Pichon M, Porter BJ, Yen JH, Ehling S. Characterization of three berry standard reference materials for nutrients. Journal of Agricultural and Food Chemistry. 59: 7246-52. PMID 21688777 DOI: 10.1021/jf200883e  0.36
2011 Sit RK, Radi? Z, Gerardi V, Zhang L, Garcia E, Katalini? M, Amitai G, Kovarik Z, Fokin VV, Sharpless KB, Taylor P. New structural scaffolds for centrally acting oxime reactivators of phosphylated cholinesterases. The Journal of Biological Chemistry. 286: 19422-30. PMID 21464125 DOI: 10.1074/jbc.M111.230656  1
2011 Gastaminza P, Pitram SM, Dreux M, Krasnova LB, Whitten-Bauer C, Dong J, Chung J, Fokin VV, Sharpless KB, Chisari FV. Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection. Journal of Virology. 85: 5513-23. PMID 21430055 DOI: 10.1128/JVI.02116-10  1
2011 Sander LC, Sharpless KE, Wise SA, Nelson BC, Phinney KW, Porter BJ, Rimmer CA, Thomas JB, Wood LJ, Yen JH, Duewer DL, Atkinson R, Chen P, Goldschmidt R, Wolf WR, et al. Certification of vitamins and carotenoids in SRM 3280 multivitamin/multielement tablets. Analytical Chemistry. 83: 99-108. PMID 21128589 DOI: 10.1021/ac101953u  0.36
2011 Phinney KW, Rimmer CA, Thomas JB, Sander LC, Sharpless KE, Wise SA. Isotope dilution liquid chromatography - mass spectrometry methods for fat- and water-soluble vitamins in nutritional formulations. Analytical Chemistry. 83: 92-8. PMID 21117618 DOI: 10.1021/ac101950r  0.36
2010 Sharpless KE, Lindstrom RM, Nelson BC, Phinney KW, Rimmer CA, Sander LC, Schantz MM, Spatz RO, Thomas JB, Turk GC, Wise SA, Wood LJ, Yen JH. Preparation and characterization of standard reference material 1849 infant/adult nutritional formula. Journal of Aoac International. 93: 1262-74. PMID 20922961  0.36
2010 Weide T, Saldanha SA, Minond D, Spicer TP, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder PS, Fokin VV. NH-1,2,3-Triazole-based Inhibitors of the VIM-2 Metallo-β-Lactamase: Synthesis and Structure-Activity Studies. Acs Medicinal Chemistry Letters. 1: 150-154. PMID 20625539 DOI: 10.1021/ml900022q  1
2010 Phillips MM, Case RJ, Rimmer CA, Sander LC, Sharpless KE, Wise SA, Yen JH. Determination of organic acids in Vaccinium berry standard reference materials. Analytical and Bioanalytical Chemistry. 398: 425-34. PMID 20582402 DOI: 10.1007/s00216-010-3916-0  0.36
2010 Bedner M, Sander LC, Sharpless KE. An LC-ESI/MS method for determining theanine in green tea dietary supplements Analytical and Bioanalytical Chemistry. 397: 1773-1777. PMID 20422160 DOI: 10.1007/s00216-010-3713-9  0.36
2010 Radi? Z, Kalisiak J, Fokin VV, Sharpless KB, Taylor P. Interaction kinetics of oximes with native, phosphylated and aged human acetylcholinesterase. Chemico-Biological Interactions. 187: 163-6. PMID 20412789 DOI: 10.1016/j.cbi.2010.04.014  1
2009 Hein JE, Tripp JC, Krasnova LB, Sharpless KB, Fokin VV. Copper(I)-catalyzed cycloaddition of organic azides and 1-iodoalkynes. Angewandte Chemie (International Ed. in English). 48: 8018-21. PMID 19774581 DOI: 10.1002/anie.200903558  0.92
2009 Duewer DL, Lippa KA, Long SE, Murphy KE, Sharpless KE, Sniegoski LT, Welch MJ, Tani W, Umemoto M. Demonstrating the comparability of certified reference materials. Analytical and Bioanalytical Chemistry. 395: 155-69. PMID 19629455 DOI: 10.1007/s00216-009-2949-8  0.36
2009 Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P. Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries. Bioorganic & Medicinal Chemistry. 17: 5027-37. PMID 19553129 DOI: 10.1016/j.bmc.2009.05.070  0.92
2009 Valdez CA, Tripp JC, Miyamoto Y, Kalisiak J, Hruz P, Andersen YS, Brown SE, Kangas K, Arzu LV, Davids BJ, Gillin FD, Upcroft JA, Upcroft P, Fokin VV, Smith DK, ... Sharpless KB, et al. Synthesis and electrochemistry of 2-ethenyl and 2-ethanyl derivatives of 5-nitroimidazole and antimicrobial activity against Giardia lamblia. Journal of Medicinal Chemistry. 52: 4038-53. PMID 19480409 DOI: 10.1021/jm900356n  0.92
2009 Hirose T, Sunazuka T, Sugawara A, Endo A, Iguchi K, Yamamoto T, Ui H, Shiomi K, Watanabe T, Sharpless KB, Omura S. Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry. The Journal of Antibiotics. 62: 277-82. PMID 19329983 DOI: 10.1038/ja.2009.28  0.92
2009 Agnew HD, Rohde RD, Millward SW, Nag A, Yeo WS, Hein JE, Pitram SM, Tariq AA, Burns VM, Krom RJ, Fokin VV, Sharpless KB, Heath JR. Iterative in situ click chemistry creates antibody-like protein-capture agents. Angewandte Chemie (International Ed. in English). 48: 4944-8. PMID 19301344 DOI: 10.1002/anie.200900488  1
2009 Kalisiak J, Trauger SA, Kalisiak E, Morita H, Fokin VV, Adams MW, Sharpless KB, Siuzdak G. Identification of a new endogenous metabolite and the characterization of its protein interactions through an immobilization approach. Journal of the American Chemical Society. 131: 378-86. PMID 19055353 DOI: 10.1021/ja808172n  0.92
2009 Sander L, Schantz M, Sharpless K, Wise S. Standard Reference Materials to support measurement of fatty acids Lipid Technology. 21: 7-12. DOI: 10.1002/lite.200800080  0.36
2009 Schantz MM, Christopher SJ, Davis WC, Day RD, Keller JM, Kucklick JR, Long SE, Mackey EA, Point D, Porter BJ, Poster DL, Sharpless KE, Turk GC, Wise SA. Fish-Related: Standard reference materials American Laboratory. 41: 50-53.  0.36
2008 Dwyer JT, Picciano MF, Betz JM, Fisher KD, Saldanha LG, Yetley EA, Coates PM, Milner JA, Whitted J, Burt V, Radimer K, Wilger J, Sharpless KE, Holden JM, Andrews K, et al. Progress in developing analytical and label-based dietary supplement databases at the NIH Office of Dietary Supplements. Journal of Food Composition and Analysis : An Official Publication of the United Nations University, International Network of Food Data Systems. 21: S83-S93. PMID 25346570 DOI: 10.1016/j.jfca.2007.07.010  0.36
2008 Kwok SW, Hein JE, Fokin VV, Sharpless KB. REGIOSELECTIVE SYNTHESIS OF EITHER 1H- OR 2H-1,2,3- TRIAZOLES VIA MICHAEL ADDITION TO α,ß-UNSATURATED KETONES. Heterocycles. 76: 1141-1154. PMID 19802363 DOI: 10.3987/COM-08-S(N)73  0.92
2008 Sharpless KE, Duewer DL. Standard reference materials for analysis of dietary supplements Journal of Aoac International. 91: 1298-1302. PMID 19202789  0.36
2008 Schantz MM, Bedner M, Long SE, Molloy JL, Murphy KE, Porter BJ, Putzbach K, Rimmer CA, Sander LC, Sharpless KE, Thomas JB, Wise SA, Wood LJ, Yen JH, Yarita T, et al. Development of saw palmetto (Serenoa repens) fruit and extract standard reference materials. Analytical and Bioanalytical Chemistry. 392: 427-38. PMID 18677464 DOI: 10.1007/s00216-008-2297-0  0.36
2008 Kalisiak J, Sharpless KB, Fokin VV. Efficient synthesis of 2-substituted-1,2,3-triazoles. Organic Letters. 10: 3171-4. PMID 18597477 DOI: 10.1021/ol8006748  0.92
2008 Nelson BC, Pfeiffer CM, Zhang M, Duewer DL, Sharpless KE, Lippa KA. Commutability of NIST SRM 1955 Homocysteine and Folate in Frozen Human Serum with selected total homocysteine immunoassays and enzymatic assays Clinica Chimica Acta. 395: 99-105. PMID 18565331 DOI: 10.1016/j.cca.2008.05.016  0.36
2008 Yoo EJ, Ahlquist M, Bae I, Sharpless KB, Fokin VV, Chang S. Mechanistic studies on the Cu-catalyzed three-component reactions of sulfonyl azides, 1-alkynes and amines, alcohols, or water: dichotomy via a common pathway. The Journal of Organic Chemistry. 73: 5520-8. PMID 18557650 DOI: 10.1021/jo800733p  0.92
2008 Radi? Z, Manetsch R, Fournier D, Sharpless KB, Taylor P. Probing gorge dimensions of cholinesterases by freeze-frame click chemistry. Chemico-Biological Interactions. 175: 161-5. PMID 18555981 DOI: 10.1016/j.cbi.2008.04.048  0.92
2008 Sander LC, Putzbach K, Nelson BC, Rimmer CA, Bedner M, Thomas JB, Porter BJ, Wood LJ, Schantz MM, Murphy KE, Sharpless KE, Wise SA, Yen JH, Siitonen PH, Evans RL, et al. Certification of standard reference materials containing bitter orange. Analytical and Bioanalytical Chemistry. 391: 2023-34. PMID 18425642 DOI: 10.1007/s00216-008-2074-0  0.36
2008 Bedner M, Schantz MM, Sander LC, Sharpless KE. Development of liquid chromatographic methods for the determination of phytosterols in Standard Reference Materials containing saw palmetto Journal of Chromatography A. 1192: 74-80. PMID 18374927 DOI: 10.1016/j.chroma.2008.03.020  0.36
2008 Saupe SG, Sharpless KE. Solution to "doctrine of Signatures" challenge Analytical and Bioanalytical Chemistry. 390: 79-83. PMID 18074123 DOI: 10.1007/s00216-007-1743-8  0.36
2008 Roseland JM, Holden JM, Andrews KW, Zhao C, Schweitzer A, Harnly J, Wolf WR, Perry CR, Dwyer JT, Picciano MF, Betz JM, Saldanha LG, Yetley EA, Fisher KD, Sharpless KE. Dietary supplement ingredient database (DSID): Preliminary USDA studies on the composition of adult multivitamin/mineral supplements Journal of Food Composition and Analysis. 21: S69-S77. DOI: 10.1016/j.jfca.2007.07.009  0.36
2008 Santana J, Sharpless KE, Nelson BC. Determination of para-synephrine and meta-synephrine positional isomers in bitter orange-containing dietary supplements by LC/UV and LC/MS/MS Food Chemistry. 109: 675-682. DOI: 10.1016/j.foodchem.2007.12.076  0.36
2008 Finn MG, Kolb HC, Fokin VV, Sharpless KB. Click chemistry - Definition and aims Progress in Chemistry. 20: 1-4.  0.92
2007 Nelson BC, Putzbach K, Sharpless KE, Sander LC. Mass spectrometric determination of the predominant adrenergic protoalkaloids in bitter orange (Citrus aurantium) Journal of Agricultural and Food Chemistry. 55: 9769-9775. PMID 17966980 DOI: 10.1021/jf072030s  0.36
2007 Sugawara A, Sunazuka T, Hirose T, Nagai K, Yamaguchi Y, Hanaki H, Sharpless KB, Omura S. Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. Bioorganic & Medicinal Chemistry Letters. 17: 6340-4. PMID 17869508 DOI: 10.1016/j.bmcl.2007.08.068  0.92
2007 Thomas JB, Sharpless KE, Mitvalsky S, Roman M, Yen J, Satterfield MB. Determination of caffeine and caffeine-related metabolites in ephedra-containing standard reference materials using liquid chromatography with absorbance detection and tandem mass spectrometry. Journal of Aoac International. 90: 934-40. PMID 17760330  0.36
2007 Schantz MM, Keller JM, Leigh S, Patterson DG, Sharpless KE, Sjödin A, Stapleton HM, Swarthout R, Turner WE, Wise SA. Certification of SRM 1589a PCBs, pesticides, PBDEs, and dioxins/furans in human serum Analytical and Bioanalytical Chemistry. 389: 1201-1208. PMID 17710387 DOI: 10.1007/s00216-007-1519-1  0.36
2007 Saupe SG, Sharpless KE. "doctrine of Signatures" challenge Analytical and Bioanalytical Chemistry. 389: 3-9. PMID 17646970 DOI: 10.1007/s00216-007-1465-y  0.36
2007 Dwyer JT, Holden J, Andrews K, Roseland J, Zhao C, Schweitzer A, Perry CR, Harnly J, Wolf WR, Picciano MF, Fisher KD, Saldanha LG, Yetley EA, Betz JM, Coates PM, ... ... Sharpless KE, et al. Measuring vitamins and minerals in dietary supplements for nutrition studies in the USA. Analytical and Bioanalytical Chemistry. 389: 37-46. PMID 17641882 DOI: 10.1007/s00216-007-1456-z  0.36
2007 Rimmer CA, Howerton SB, Sharpless KE, Sander LC, Long SE, Murphy KE, Porter BJ, Putzbach K, Rearick MS, Wise SA, Wood LJ, Zeisler R, Hancock DK, Yen JH, Betz JM, et al. Characterization of a suite of ginkgo-containing standard reference materials. Analytical and Bioanalytical Chemistry. 389: 179-96. PMID 17619180 DOI: 10.1007/s00216-007-1398-5  0.36
2007 Phillips KM, Wolf WR, Patterson KY, Sharpless KE, Holden JM. Reference materials to evaluate measurement systems for the nutrient composition of foods: Results from USDA's National Food and Nutrient Analysis Program (NFNAP) Analytical and Bioanalytical Chemistry. 389: 219-229. PMID 17583804 DOI: 10.1007/s00216-007-1366-0  0.36
2007 Putzbach K, Rimmer CA, Sharpless KE, Wise SA, Sander LC. Determination of bitter orange alkaloids in dietary supplement Standard Reference Materials by liquid chromatography with atmospheric-pressure ionization mass spectrometry Analytical and Bioanalytical Chemistry. 389: 197-205. PMID 17579842 DOI: 10.1007/s00216-007-1409-6  0.36
2007 Sharpless KE, Thomas JB, Christopher SJ, Greenberg RR, Sander LC, Schantz MM, Welch MJ, Wise SA. Standard reference materials for foods and dietary supplements. Analytical and Bioanalytical Chemistry. 389: 171-8. PMID 17534610 DOI: 10.1007/s00216-007-1315-y  0.36
2007 Putzbach K, Rimmer CA, Sharpless KE, Sander LC. Determination of Bitter Orange alkaloids in dietary supplements standard reference materials by liquid chromatography with ultraviolet absorbance and fluorescence detection Journal of Chromatography A. 1156: 304-311. PMID 17524413 DOI: 10.1016/j.chroma.2006.12.027  0.36
2007 Sharpless KE, Thomas JB, Duewer DL, Putzbach K, Rimmer CA, Sander LC, Schantz MM, Wise SA, Yarita T, Yen JH. Preparation and characterization of standard reference material 3276, carrot extract in oil. Analytical and Bioanalytical Chemistry. 389: 207-17. PMID 17440713 DOI: 10.1007/s00216-007-1278-z  0.36
2007 Yoo EJ, Ahlquist M, Kim SH, Bae I, Fokin VV, Sharpless KB, Chang S. Copper-catalyzed synthesis of N-sulfonyl-1,2,3-triazoles: controlling selectivity. Angewandte Chemie (International Ed. in English). 46: 1730-3. PMID 17397087 DOI: 10.1002/anie.200604241  0.92
2007 Hawker CJ, Fokin VV, Finn MG, Sharpless KB. Bringing efficiency to materials synthesis: The philosophy of click chemistry Australian Journal of Chemistry. 60: 381-383. DOI: 10.1071/CH07107  0.92
2007 Phillips KM, Wolf WR, Patterson KY, Sharpless KE, Amanna KR, Holden JM. Summary of reference materials for the determination of the nutrient composition of foods Accreditation and Quality Assurance. 12: 126-133. DOI: 10.1007/s00769-007-0257-6  0.36
2007 Sharpless KE, Ulberth F. Food and dietary supplements Analytical and Bioanalytical Chemistry. 389: 1-2. DOI: 10.1007/s00216-007-1473-y  0.36
2007 Liu Y, Díaz DD, Accurso AA, Sharpless KB, Fokin VV, Finn MG. Click chemistry in materials synthesis. III. Metal-adhesive polymers from Cu(I)-catalyzed azide-alkyne cycloaddition Journal of Polymer Science, Part a: Polymer Chemistry. 45: 5182-5189. DOI: 10.1002/pola.22262  0.92
2007 Vestberg R, Malkoch M, Kade M, Wu P, Fokin VV, Sharpless KB, Drockenmuller E, Hawker CJ. Role of architecture and molecular weight in the formation of tailor-made ultrathin multilayers using dendritic macromolecules and click chemistry Journal of Polymer Science, Part a: Polymer Chemistry. 45: 2835-2846. DOI: 10.1002/pola.22178  0.92
2007 Narayan S, Fokin VV, Sharpless KB. Chemistry 'On Water'-Organic Synthesis in Aqueous Suspension Organic Reactions in Water: Principles, Strategies and Applications. 350-365. DOI: 10.1002/9780470988817.ch11  1
2006 Dwyer JT, Picciano MF, Betz JM, Fisher KD, Saldanha LG, Yetley EA, Coates PM, Radimer K, Bindewald B, Sharpless KE, Holden J, Andrews K, Zhao C, Harnly J, Wolf WR, et al. Progress in development of an integrated dietary supplement ingredient database at the NIH Office of Dietary Supplements. Journal of Food Composition and Analysis : An Official Publication of the United Nations University, International Network of Food Data Systems. 19: S108-S114. PMID 25309034 DOI: 10.1016/j.jfca.2005.09.001  0.36
2006 Sharpless KB, Manetsch R. In situ click chemistry: a powerful means for lead discovery. Expert Opinion On Drug Discovery. 1: 525-38. PMID 23506064 DOI: 10.1517/17460441.1.6.525  1
2006 Díaz DD, Converso A, Sharpless KB, Finn MG. 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: multigram display of azide and cyanide components on a versatile scaffold. Molecules (Basel, Switzerland). 11: 212-8. PMID 17962753 DOI: 10.3390/11040212  1
2006 Sharpless KE, Anderson DL, Betz JM, Butler TA, Capar SG, Cheng J, Fraser CA, Gardner G, Gay ML, Howell DW, Ihara T, Khan MA, Lam JW, Long SE, McCooeye M, et al. Preparation and characterization of a suite of ephedra-containing standard reference materials. Journal of Aoac International. 89: 1483-95. PMID 17225593  0.36
2006 Whiting M, Tripp JC, Lin YC, Lindstrom W, Olson AJ, Elder JH, Sharpless KB, Fokin VV. Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization. Journal of Medicinal Chemistry. 49: 7697-710. PMID 17181152 DOI: 10.1021/jm060754+  1
2006 Nelson BC, Sharpless KE, Sander LC. Improved liquid chromatography methods for the separation and quantification of biotin in NIST Standard Reference Material 3280: Multivitamin/multielement tablets Journal of Agricultural and Food Chemistry. 54: 8710-8716. PMID 17090111 DOI: 10.1021/jf062000+  0.36
2006 Nelson BC, Sharpless KE, Sander LC. Quantitative determination of folic acid in multivitamin/multielement tablets using liquid chromatography/tandem mass spectrometry Journal of Chromatography A. 1135: 203-211. PMID 17018234 DOI: 10.1016/j.chroma.2006.09.040  0.36
2006 Satterfield MB, Sniegoski LT, Sharpless KE, Welch MJ, Hornikova A, Zhang NF, Pfeiffer CM, Fazili Z, Zhang M, Nelson BC. Development of a new standard reference material: SRM 1955 (homocysteine and folate in human serum). Analytical and Bioanalytical Chemistry. 385: 612-22. PMID 16715281 DOI: 10.1007/s00216-006-0434-1  0.36
2006 Sander LC, Sharpless KE, Wise SA. Dietary supplement Standard Reference Materials Life Sciences. 78: 2044-2048. PMID 16457853 DOI: 10.1016/j.lfs.2005.12.037  0.36
2006 Whiting M, Muldoon J, Lin YC, Silverman SM, Lindstrom W, Olson AJ, Kolb HC, Finn MG, Sharpless KB, Elder JH, Fokin VV. Inhibitors of HIV-1 protease by using in situ click chemistry. Angewandte Chemie (International Ed. in English). 45: 1435-9. PMID 16425339 DOI: 10.1002/anie.200502161  1
2006 Hirose T, Sunazuka T, Noguchi Y, Yamaguchi Y, Hanaki H, Sharpless KB, Omura S. Rapid 'SAR' via click chemistry: An alkyne-bearing spiramycin is fused with diverse azides to yield new triazole-antibacterial candidates Heterocycles. 69: 55-61.  0.92
2005 Wu P, Malkoch M, Hunt JN, Vestberg R, Kaltgrad E, Finn MG, Fokin VV, Sharpless KB, Hawker CJ. Multivalent, bifunctional dendrimers prepared by click chemistry. Chemical Communications (Cambridge, England). 5775-7. PMID 16307142 DOI: 10.1039/b512021g  1
2005 Radi? Z, Manetsch R, Krasi?ski A, Raushel J, Yamauchi J, Garcia C, Kolb H, Sharpless KB, Taylor P. Molecular basis of interactions of cholinesterases with tight binding inhibitors. Chemico-Biological Interactions. 157: 133-41. PMID 16289416 DOI: 10.1016/j.cbi.2005.10.020  1
2005 Zhang L, Chen X, Xue P, Sun HH, Williams ID, Sharpless KB, Fokin VV, Jia G. Ruthenium-catalyzed cycloaddition of alkynes and organic azides. Journal of the American Chemical Society. 127: 15998-9. PMID 16287266 DOI: 10.1021/ja054114s  1
2005 Bourne Y, Radi? Z, Kolb HC, Sharpless KB, Taylor P, Marchot P. Structural insights into conformational flexibility at the peripheral site and within the active center gorge of AChE. Chemico-Biological Interactions. 157: 159-65. PMID 16259971 DOI: 10.1016/j.cbi.2005.10.018  1
2005 Feldman AK, Colasson B, Sharpless KB, Fokin VV. The allylic azide rearrangement: achieving selectivity. Journal of the American Chemical Society. 127: 13444-5. PMID 16190677 DOI: 10.1021/ja050622q  1
2005 Sander LC, Sharpless KE, Satterfield MB, Ihara T, Phinney KW, Yen JH, Wise SA, Gay ML, Lam JW, McCooeye M, Gardner G, Fraser C, Sturgeon R, Roman M. Determination of ephedrine alkaloids in dietary supplement standard reference materials. Analytical Chemistry. 77: 3101-12. PMID 15889898 DOI: 10.1021/ac0484530  0.36
2005 Krasi?ski A, Radi? Z, Manetsch R, Raushel J, Taylor P, Sharpless KB, Kolb HC. In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. Journal of the American Chemical Society. 127: 6686-92. PMID 15869290 DOI: 10.1021/ja043031t  1
2005 Narayan S, Muldoon J, Finn MG, Fokin VV, Kolb HC, Sharpless KB. "On water": unique reactivity of organic compounds in aqueous suspension. Angewandte Chemie (International Ed. in English). 44: 3275-9. PMID 15844112 DOI: 10.1002/anie.200462883  1
2005 Woollard DC, Shoemaker DD, Ackman RG, Eitenmiller RR, Mossoba MM, Sharpless KE, Smith R, Wolf WR, Bonnin E, Phillips JG, Williams SM. Committee on Food Nutrition. Journal of Aoac International. 88: 371-2. PMID 15759763  0.36
2005 Johnson SM, Petrassi HM, Palaninathan SK, Mohamedmohaideen NN, Purkey HE, Nichols C, Chiang KP, Walkup T, Sacchettini JC, Sharpless KB, Kelly JW. Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation. Journal of Medicinal Chemistry. 48: 1576-87. PMID 15743199 DOI: 10.1021/jm049274d  1
2005 Himo F, Lovell T, Hilgraf R, Rostovtsev VV, Noodleman L, Sharpless KB, Fokin VV. Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates. Journal of the American Chemical Society. 127: 210-6. PMID 15631470 DOI: 10.1021/ja0471525  0.92
2005 Loren JC, Krasiński A, Fokin VV, Sharpless KB. NH-1,2,3-triazoles from azidomethyl pivalate and carbamates: Base-labile N-protecting groups Synlett. 2847-2850. DOI: 10.1055/s-2005-918944  1
2005 Loren JC, Sharpless KB. The Banert cascade: A synthetic sequence to polyfunctional NH-1,2,3-triazoles Synthesis. 1514-1520. DOI: 10.1055/s-2005-869892  1
2004 Mocharla VP, Colasson B, Lee LV, Röper S, Sharpless KB, Wong CH, Kolb HC. In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II. Angewandte Chemie (International Ed. in English). 44: 116-20. PMID 15599912 DOI: 10.1002/anie.200461580  0.92
2004 Converso A, Saaidi PL, Sharpless KB, Finn MG. Nucleophilic substitution by grignard reagents on sulfur mustards. The Journal of Organic Chemistry. 69: 7336-9. PMID 15471488 DOI: 10.1021/jo0489869  1
2004 Manetsch R, Krasi?ski A, Radi? Z, Raushel J, Taylor P, Sharpless KB, Kolb HC. In situ click chemistry: enzyme inhibitors made to their own specifications. Journal of the American Chemical Society. 126: 12809-18. PMID 15469276 DOI: 10.1021/ja046382g  1
2004 Chan TR, Hilgraf R, Sharpless KB, Fokin VV. Polytriazoles as copper(I)-stabilizing ligands in catalysis. Organic Letters. 6: 2853-5. PMID 15330631 DOI: 10.1021/ol0493094  1
2004 Wu P, Feldman AK, Nugent AK, Hawker CJ, Scheel A, Voit B, Pyun J, Fréchet JM, Sharpless KB, Fokin VV. Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(i)-catalyzed ligation of azides and alkynes. Angewandte Chemie (International Ed. in English). 43: 3928-32. PMID 15274216 DOI: 10.1002/anie.200454078  1
2004 Thomas JB, Yen JH, Schantz MM, Porter BJ, Sharpless KE. Determination of caffeine, theobromine, and theophylline in standard reference material 2384, baking chocolate, using reversed-phase liquid chromatography. Journal of Agricultural and Food Chemistry. 52: 3259-63. PMID 15161179 DOI: 10.1021/jf030817m  0.36
2004 Pearson CL, Xu K, Sharpless KE, Harris SD. MesA, a novel fungal protein required for the stabilization of polarity axes in Aspergillus nidulans. Molecular Biology of the Cell. 15: 3658-72. PMID 15155805 DOI: 10.1091/mbc.E03-11-0803  0.44
2004 Krasi?ski A, Fokin VV, Sharpless KB. Direct synthesis of 1,5-disubstituted-4-magnesio-1,2,3-triazoles, revisited. Organic Letters. 6: 1237-40. PMID 15070306 DOI: 10.1021/ol0499203  1
2004 Bourne Y, Kolb HC, Radi? Z, Sharpless KB, Taylor P, Marchot P. Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation. Proceedings of the National Academy of Sciences of the United States of America. 101: 1449-54. PMID 14757816 DOI: 10.1073/pnas.0308206100  1
2004 Sharpless KE, Greenberg RR, Schantz MM, Welch MJ, Wise SA, Ihnat M. Filling the AOAC triangle with food-matrix standard reference materials Analytical and Bioanalytical Chemistry. 378: 1161-1167. PMID 14689156 DOI: 10.1007/s00216-003-2384-1  0.36
2004 Wise SA, Sharpless KE, Sander LC, May WE. Standard Reference Materials to support US regulations for nutrients and contaminants in food and dietary supplements Accreditation and Quality Assurance. 9: 543-550. DOI: 10.1007/s00769-004-0820-3  0.36
2004 Díaz DD, Punna S, Holzer P, Mcpherson AK, Sharpless KB, Fokin VV, Finn MG. Click chemistry in materials synthesis. 1. Adhesive polymers from copper-catalyzed azide-alkyne cycloaddition Journal of Polymer Science, Part a: Polymer Chemistry. 42: 4392-4403. DOI: 10.1002/pola.20330  1
2003 Kolb HC, Sharpless KB. The growing impact of click chemistry on drug discovery. Drug Discovery Today. 8: 1128-37. PMID 14678739 DOI: 10.1016/S1359-6446(03)02933-7  1
2003 Zhou X, Wang X, Dougherty ER. Missing-value estimation using linear and non-linear regression with Bayesian gene selection. Bioinformatics (Oxford, England). 19: 2302-7. PMID 14630659  0.52
2003 Brik A, Muldoon J, Lin YC, Elder JH, Goodsell DS, Olson AJ, Fokin VV, Sharpless KB, Wong CH. Rapid diversity-oriented synthesis in microtiter plates for in situ screening of HIV protease inhibitors. Chembiochem : a European Journal of Chemical Biology. 4: 1246-8. PMID 14613121 DOI: 10.1002/cbic.200300724  1
2003 Sharpless KE, Phinney CS, Wood LJ, Yen JH, Howell DW. Value assignment of nutrient and aflatoxin concentrations in standard reference material 2387 peanut butter. Journal of Agricultural and Food Chemistry. 51: 6745-51. PMID 14582970 DOI: 10.1021/jf034637o  0.36
2003 Himo F, Demko ZP, Noodleman L, Sharpless KB. Why is tetrazole formation by addition of azide to organic nitriles catalyzed by zinc(II) salts? Journal of the American Chemical Society. 125: 9983-7. PMID 12914461 DOI: 10.1021/ja030204q  1
2003 Lee LV, Mitchell ML, Huang SJ, Fokin VV, Sharpless KB, Wong CH. A potent and highly selective inhibitor of human alpha-1,3-fucosyltransferase via click chemistry. Journal of the American Chemical Society. 125: 9588-9. PMID 12904015 DOI: 10.1021/ja0302836  1
2003 Ripka AS, Díaz DD, Sharpless KB, Finn MG. First practical synthesis of formamidine ureas and derivatives. Organic Letters. 5: 1531-3. PMID 12713316 DOI: 10.1021/ol034287r  1
2003 Wang Q, Chan TR, Hilgraf R, Fokin VV, Sharpless KB, Finn MG. Bioconjugation by copper(I)-catalyzed azide-alkyne [3 + 2] cycloaddition. Journal of the American Chemical Society. 125: 3192-3. PMID 12630856 DOI: 10.1021/ja021381e  1
2003 Nelson BC, Sharpless KE. Quantification of the predominant monomeric catechins in baking chocolate standard reference material by LC/APCI-MS Journal of Agricultural and Food Chemistry. 51: 531-537. PMID 12537419 DOI: 10.1021/jf0207474  0.36
2003 Kitayama T, Yokoi T, Kawai Y, Hill RK, Morita M, Okamoto T, Yamamoto Y, Fokin VV, Sharpless KB, Sawada S. The chemistry of zerumbone. Part 5: Structural transformation of the dimethylamine derivatives Tetrahedron. 59: 4857-4866. DOI: 10.1016/S0040-4020(03)00667-7  1
2002 Demko ZP, Sharpless KB. A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-acyltetrazoles from azides and acyl cyanides. Angewandte Chemie (International Ed. in English). 41: 2113-6. PMID 19746613 DOI: 10.1002/1521-3773(20020617)41:12<2113::AID-ANIE2113>3.0.CO;2-Q  0.92
2002 Demko ZP, Sharpless KB. A click chemistry approach to tetrazoles by Huisgen 1,3-dipolar cycloaddition: synthesis of 5-sulfonyl tetrazoles from azides and sulfonyl cyanides. Angewandte Chemie (International Ed. in English). 41: 2110-3. PMID 19746612 DOI: 10.1002/1521-3773(20020617)41:12<2110::AID-ANIE2110>3.0.CO;2-7  0.92
2002 Sharpless KB. Searching for new reactivity (Nobel lecture). Angewandte Chemie (International Ed. in English). 41: 2024-32. PMID 19746596 DOI: 10.1002/1521-3773(20020617)41:12<2024::AID-ANIE2024>3.0.CO;2-O  0.92
2002 Andersson MA, Epple R, Fokin VV, Sharpless KB. A new approach to osmium-catalyzed asymmetric dihydroxylation and aminohydroxylation of olefins. Angewandte Chemie (International Ed. in English). 41: 472-5. PMID 12491382 DOI: 10.1002/1521-3773(20020201)41:3<472::AID-ANIE472>3.0.CO;2-7  1
2002 Lewis WG, Green LG, Grynszpan F, Radi? Z, Carlier PR, Taylor P, Finn MG, Sharpless KB. Click chemistry in situ: acetylcholinesterase as a reaction vessel for the selective assembly of a femtomolar inhibitor from an array of building blocks. Angewandte Chemie (International Ed. in English). 41: 1053-7. PMID 12491310 DOI: 10.1002/1521-3773(20020315)41:6<1053::AID-ANIE1053>3.0.CO;2-4  0.92
2002 Sharpless KE, Brown Thomas J, Nelson BC, Phinney CS, Sieber JR, Wood LJ, Yen JH, Howell DW. Value assignment of nutrient concentrations in standard reference material 2384 baking chocolate. Journal of Agricultural and Food Chemistry. 50: 7069-75. PMID 12428961 DOI: 10.1021/jf020610d  0.36
2002 Himo F, Demko ZP, Noodleman L, Sharpless KB. Mechanisms of tetrazole formation by addition of azide to nitriles. Journal of the American Chemical Society. 124: 12210-6. PMID 12371861 DOI: 10.1021/ja0206644  1
2002 Rostovtsev VV, Green LG, Fokin VV, Sharpless KB. A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. Angewandte Chemie (International Ed. in English). 41: 2596-9. PMID 12203546 DOI: 10.1002/1521-3773(20020715)41:14<2596::AID-ANIE2596>3.0.CO;2-4  1
2002 Demko ZP, Sharpless KB. An expedient route to the tetrazole analogues of alpha-amino acids. Organic Letters. 4: 2525-7. PMID 12123367 DOI: 10.1021/ol020096x  1
2002 Sharpless KE, Harris SD. Functional characterization and localization of the Aspergillus nidulans formin SEPA Molecular Biology of the Cell. 13: 469-479. PMID 11854405 DOI: 10.1091/mbc.01-07-0356  0.44
2002 Dupau P, Epple R, Thomas AA, Fokin VV, Sharpless KB. Osmium-Catalyzed Dihydroxylation of Olefins in Acidic Media: Old Process, New Tricks Advanced Synthesis and Catalysis. 344: 421-433. DOI: 10.1002/1615-4169(200206)344:3/4<421::AID-ADSC421>3.0.CO;2-F  1
2001 Demko ZP, Sharpless KB. An intramolecular [2 + 3] cycloaddition route to fused 5-heterosubstituted tetrazoles. Organic Letters. 3: 4091-4. PMID 11735592 DOI: 10.1021/ol010220x  1
2001 Demko ZP, Sharpless KB. Preparation of 5-substituted 1H-tetrazoles from nitriles in water. The Journal of Organic Chemistry. 66: 7945-50. PMID 11722189 DOI: 10.1021/jo010635w  1
2001 Fokin VV, Sharpless KB. A Practical and Highly Efficient Aminohydroxylation of Unsaturated Carboxylic Acids We thank the National Institute of General Medical Sciences, the National Institutes of Health (GM 28384), National Science Foundation (CHE-9985553), and the W. M. Keck Foundation for financial support. We are also grateful to Prof. M. G. Finn, Dr. Wallace Pringle, and Dr. A. Erik Rubin for many helpful discussions. Angewandte Chemie (International Ed. in English). 40: 3455-3457. PMID 11592169 DOI: 10.1002/1521-3773(20010917)40:18<3455::AID-ANIE3455>3.0.CO;2-I  1
2001 Sharpless KE, Colbert JC, Greenberg RR, Schantz MM, Welch MJ. Recent developments in food-matrix Reference Materials at NIST Analytical and Bioanalytical Chemistry. 370: 275-278. PMID 11451251  0.36
2001 Kolb HC, Finn MG, Sharpless KB. Click Chemistry: Diverse Chemical Function from a Few Good Reactions. Angewandte Chemie (International Ed. in English). 40: 2004-2021. PMID 11433435 DOI: 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5  1
2001 Petrassi HM, Sharpless KB, Kelly JW. The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines. Organic Letters. 3: 139-42. PMID 11429858 DOI: 10.1021/ol0003533  1
2001 Marzinzik AL, Sharpless KB. A simple method for the preparation of N-sulfonylsulfilimines from sulfides. The Journal of Organic Chemistry. 66: 594-6. PMID 11429835 DOI: 10.1021/jo0012039  1
2001 Converso A, Burow K, Marzinzik A, Sharpless KB, Finn MG. 2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: a privileged, bivalent scaffold for the display of nucleophilic components. The Journal of Organic Chemistry. 66: 4386-92. PMID 11397181 DOI: 10.1021/jo015632y  1
2001 Welch MJ, Colbert JC, Gill LM, Phinney CS, Sharpless KE, Sniegoski LT, Wood LJ. The certification of SRM 1546--Meat Homogenate, a new reference material for nutrients in a high protein, high fat matrix. Fresenius' Journal of Analytical Chemistry. 370: 42-7. PMID 11393235  0.36
2001 Brown Thomas J, Kline MC, Gill LM, Yen JH, Duewer DL, Sniegoski LT, Sharpless KE. Preparation and value assignment of Standard Reference Material 968c Fat-Soluble Vitamins, Carotenoids, and Cholesterol in Human Serum. Clinica Chimica Acta; International Journal of Clinical Chemistry. 305: 141-55. PMID 11249933 DOI: 10.1016/S0009-8981(00)00429-0  0.36
2001 Irurre J, Knowles WS, Noyori R, Sharpless KB. The nobel prizes in chemistry 2001 and his contribution. A hundred years of nobel prizes (1901-2001) | Los premios nobel de química 2001 y su aportación. Cien años de premios nobel (1901-2001) Afinidad. 58: 411-415.  1
2000 Chuang TH, Sharpless KB. Applications of aziridinium ions. Selective syntheses of alpha, beta-diamino esters, alpha-sulfanyl-beta-amino esters, beta-lactams, and 1,5-benzodiazepin-2-one. Organic Letters. 2: 3555-7. PMID 11073643  0.36
2000 Duewer DL, Kline MC, Sharpless KE, Thomas JB. NIST micronutrients measurement quality assurance program: characterizing the measurement community's performance over time. Analytical Chemistry. 72: 4163-70. PMID 10994979 DOI: 10.1021/ac991480j  0.36
2000 Duewer DL, Kline MC, Sharpless KE, Thomas JB, Stacewicz-Sapuntzakis M, Sowell AL. NIST micronutrients measurement quality assurance program: characterizing individual participant measurement performance over time. Analytical Chemistry. 72: 3611-9. PMID 10952550 DOI: 10.1021/ac991481b  0.36
2000 Demko ZP, Bartsch M, Sharpless KB. Primary amides. A general nitrogen source for catalytic asymmetric aminohydroxylation of olefins. Organic Letters. 2: 2221-3. PMID 10930248  1
2000 Sharpless KE, Margolis S, Thomas JB. Determination of vitamins in food-matrix Standard Reference Materials. Journal of Chromatography. A. 881: 171-81. PMID 10905701 DOI: 10.1016/S0021-9673(00)00260-0  0.36
2000 Sander LC, Sharpless KE, Pursch M. C30 Stationary phases for the analysis of food by liquid chromatography Journal of Chromatography A. 880: 189-202. PMID 10890520 DOI: 10.1016/S0021-9673(00)00121-7  0.36
2000 Sharpless KE, Gill LM. Value assignment of nutrient concentrations in five standard reference materials and six reference materials. Journal of Aoac International. 83: 413-23. PMID 10772181  0.36
2000 Chuang TH, Sharpless KB. Applications of aziridinium ions: Selective syntheses of pyrazolidin-3-ones and pyrazolo[1,2-α]pyrazoles Helvetica Chimica Acta. 83: 1734-1743. DOI: 10.1002/1522-2675(20000809)83:8<1734::AID-HLCA1734>3.0.CO;2-E  0.92
2000 Chuang TH, Sharpless KB. Applications of aziridinium ions. Selective syntheses of α,β-diamino esters, α-sulfanyl-β-amino esters, β-lactams, and 1,5-benzodiazepin-2-one Organic Letters. 2: 3555-3557.  1
1999 Goossen LJ, Liu H, Dress KR, Sharpless KB. Catalytic asymmetric aminohydroxylation with amino-substituted heterocycles as nitrogen sources. Angewandte Chemie (International Ed. in English). 38: 1080-3. PMID 25138500 DOI: 10.1002/(SICI)1521-3773(19990419)38:8<1080::AID-ANIE1080>3.0.CO;2-D  1
1999 Thomas AA, Sharpless KB. The Catalytic Asymmetric Aminohydroxylation of Unsaturated Phosphonates. The Journal of Organic Chemistry. 64: 8379-8385. PMID 11674762 DOI: 10.1021/jo990060r  1
1999 Chuang TH, Sharpless KB. Applications of aziridinium ions. Selective syntheses of beta-aryl-alpha,beta-diamino esters. Organic Letters. 1: 1435-7. PMID 10825990  1
1999 Gontcharov AV, Liu H, Sharpless KB. Tert-butylsulfonamide. A new nitrogen source for catalytic aminohydroxylation and aziridination of olefins. Organic Letters. 1: 783-6. PMID 10823205  1
1999 Duewer DL, Kline MC, Sharpless KE, Thomas JB, Gary KT, Sowell AL. Micronutrients Measurement Quality Assurance Program: helping participants use interlaboratory comparison exercise results to improve their long-term measurement performance. Analytical Chemistry. 71: 1870-8. PMID 10330911 DOI: 10.1021/ac981074k  0.36
1999 Sharpless KE, Arce-Osuna M, Thomas JB, Gill LM. Value assignment of retinol, retinyl palmitate, tocopherol, and carotenoid concentrations in Standard Reference Material 2383 (Baby Food Composite). Journal of Aoac International. 82: 288-96. PMID 10191535  0.36
1999 Sharpless KE, Gill LM, Margolis SA, Wise SA, Elkins E. Preparation of Standard Reference Material 2383 (Baby Food Composite) and use of an interlaboratory comparison exercise for value assignment of its nutrient concentrations. Journal of Aoac International. 82: 276-87. PMID 10191534  0.36
1999 Pringle W, Sharpless KB. The osmium-catalyzed aminohydroxylation of Baylis-Hillman olefins Tetrahedron Letters. 40: 5151-5154. DOI: 10.1016/S0040-4039(99)00887-4  0.92
1999 Adolfsson H, Converso A, Sharpless KB. Comparison of amine additives most effective in the new methyltrioxorhenium-catalyzed epoxidation process Tetrahedron Letters. 40: 3991-3994. DOI: 10.1016/S0040-4039(99)00661-9  0.92
1998 Gypser A, Michel D, Nirschl DS, Sharpless KB. Dihydroxylation of Polyenes Using Narasaka's Modification of the Upjohn Procedure. The Journal of Organic Chemistry. 63: 7322-7327. PMID 11672379  0.4
1998 Brown Thomas J, Duewer DL, Kline MC, Sharpless KE. The stability of retinol, alpha-tocopherol, trans-lycopene, and trans-beta-carotene in liquid-frozen and lyophilized serum. Clinica Chimica Acta; International Journal of Clinical Chemistry. 276: 75-87. PMID 9760021 DOI: 10.1016/S0009-8981(98)00103-X  0.36
1998 Copéret C, Adolfsson H, Khuong TAV, Yudin AK, Sharpless KB. A simple and efficient method for the preparation of pyridine N-oxides Journal of Organic Chemistry. 63: 1740-1741. DOI: 10.1021/jo9723467  0.92
1998 Jeong JU, Tao B, Sagasser I, Henniges H, Sharpless KB. Bromine-catalyzed aziridination of olefins. A rare example of atom-transfer redox catalysis by a main group element Journal of the American Chemical Society. 120: 6844-6845. DOI: 10.1021/ja981419g  1
1998 Reddy KL, Dress KR, Sharpless KB. N-chloro-N-sodio-2-trimethylsilyl ethyl carbamate: A new nitrogen source for the catalytic asymmetric aminohydroxylation Tetrahedron Letters. 39: 3667-3670. DOI: 10.1016/S0040-4039(98)00644-3  0.92
1998 Tao B, Schlingloff G, Sharpless KB. Reversal of regioselection in the asymmetric aminohydroxylation of cinnamates Tetrahedron Letters. 39: 2507-2510. DOI: 10.1016/S0040-4039(98)00350-5  1
1998 Copéret C, Adolfsson H, Chiang JP, Yudin AK, Sharpless KB. A simple and efficient method for the preparation of pyridine-N-oxides II Tetrahedron Letters. 39: 761-764. DOI: 10.1016/S0040-4039(97)10619-0  1
1998 Sharpless KE, Welch MJ, Greenberg RR, Iyengar GV, Colbert JC. Recent SRMs for organic and inorganic nutrients in food matrices Fresenius' Journal of Analytical Chemistry. 360: 456-458.  0.36
1998 Dress KR, Gooßen LJ, Liu H, Jerina DM, Sharpless KB. Catalytic aminohydroxylation using adenine-derivatives as the nitrogen source Tetrahedron Letters. 39: 7669-7672.  1
1996 Vanhessche KP, Sharpless KB. Ligand-Dependent Reversal of Facial Selectivity in the Asymmetric Dihydroxylation. The Journal of Organic Chemistry. 61: 7978-7979. PMID 11667767  1
1996 Chang HT, Sharpless KB. Molar Scale Synthesis of Enantiopure Stilbene Oxide. The Journal of Organic Chemistry. 61: 6456-6457. PMID 11667495  1
1996 Li G, Sharpless KB. Catalytic asymmetric aminohydroxylation provides a short taxol side-chain synthesis. Acta Chemica Scandinavica (Copenhagen, Denmark : 1989). 50: 649-51. PMID 8756354  1
1993 Kalantar TH, Sharpless KB. Transformations of hydroxy cyclic sulfates: stereospecific conversion into 2,3,5-trisubstituted tetrahydrofurans. Acta Chemica Scandinavica (Copenhagen, Denmark : 1989). 47: 307-13. PMID 8435231  1
1993 Crispino GA, Ho PT, Sharpless KB. Selective perhydroxylation of squalene: taming the arithmetic demon. Science (New York, N.Y.). 259: 64-6. PMID 8418495  1
1983 Ko SY, Lee AW, Masamune S, Reed LA, Sharpless KB, Walker FJ. Total synthesis of the L-hexoses. Science (New York, N.Y.). 220: 949-51. PMID 17816019 DOI: 10.1126/science.220.4600.949  0.32
1971 Sharpless KB, Flood TC. Oxotransition metal oxidants as mimics for the action of mixed-function oxygenases. "NIH shift" with chromyl reagents. Journal of the American Chemical Society. 93: 2316-8. PMID 5553075  0.32
1970 Rahman R, Sharpless KB, Spencer TA, Clayton RB. Removal of the 4,4-dimethyl carbons in the enzymic conversion of lanosterol to cholesterol. Initial loss of the 4-alpha-methyl group. The Journal of Biological Chemistry. 245: 2667-71. PMID 5445804  1
1969 Sharpless KB, Snyder TE, Spencer TA, Maheshwari KK, Nelson JA. Biological demethylation of 4,4-dimethyl sterols, Evidence for enzymic epimerization of the 4beta-methyl group prior to its oxidative removal. Journal of the American Chemical Society. 91: 3394-6. PMID 5791927  0.92
1967 van Tamelen EE, Sharpless KB, Hanzlik R, Clayton RB, Burlingame AL, Wszolek PC. Enzymic cyclization of trans,trans,trans-18,19-dihydrosqualene 2,3-oxide. Journal of the American Chemical Society. 89: 7150-1. PMID 6064361  0.56
1967 Willett JD, Sharpless KB, Lord KE, van Tamelen EE, Clayton RB. Squalene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol. The Journal of Biological Chemistry. 242: 4182-91. PMID 6061706  1
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