Aaron Ciechanover - Publications

Affiliations: 
Technion - Israel Institute of Technology, Haifa, Haifa District, Israel 
Area:
Biochemistry
Website:
http://nobelprize.org/nobel_prizes/chemistry/laureates/2004/ciechanover.html

204 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Sun H, Mali SM, Singh SK, Meledin R, Brik A, Kwon YT, Kravtsova-Ivantsiv Y, Bercovich B, Ciechanover A. Diverse fate of ubiquitin chain moieties: The proximal is degraded with the target, and the distal protects the proximal from removal and recycles. Proceedings of the National Academy of Sciences of the United States of America. PMID 30867293 DOI: 10.1073/pnas.1822148116  0.64
2017 Magnani ND, Dada LA, Queisser MA, Brazee PL, Welch LC, Anekalla KR, Zhou G, Vagin O, Misharin AV, Budinger GRS, Iwai K, Ciechanover AJ, Sznajder JI. HIF and HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury. Proceedings of the National Academy of Sciences of the United States of America. PMID 29109255 DOI: 10.1073/pnas.1713563114  0.6
2017 Livneh I, Kravtsova-Ivantsiv Y, Braten O, Kwon YT, Ciechanover A. Monoubiquitination joins polyubiquitination as an esteemed proteasomal targeting signal. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. PMID 28493408 DOI: 10.1002/bies.201700027  0.64
2017 Iida Y, Ciechanover A, Marzese DM, Hata K, Bustos M, Ono S, Wang J, Salomon MP, Tran K, Lam S, Hsu SC, Nelson N, Kravtsova-Ivantsiv Y, Mills GB, Davies MA, et al. Epigenetic Regulation of KPC1 Ubiquitin Ligase Effects the NF-κB Pathway in Melanoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28389511 DOI: 10.1158/1078-0432.CCR-17-0146  0.64
2016 Lahav-Baratz S, Kravtsova-Ivantsiv Y, Golan S, Ciechanover A. The testis-specific USP26 is a deubiquitinating enzyme of the ubiquitin ligase Mdm2. Biochemical and Biophysical Research Communications. PMID 27810359 DOI: 10.1016/j.bbrc.2016.10.135  0.64
2016 Braten O, Livneh I, Ziv T, Admon A, Kehat I, Caspi LH, Gonen H, Bercovich B, Godzik A, Jahandideh S, Jaroszewski L, Sommer T, Kwon YT, Guharoy M, Tompa P, ... Ciechanover A, et al. Numerous proteins with unique characteristics are degraded by the 26S proteasome following monoubiquitination. Proceedings of the National Academy of Sciences of the United States of America. PMID 27385826 DOI: 10.1073/pnas.1608644113  1
2016 Eisenberg-Lerner A, Ciechanover A, Merbl Y. Post-translational modification profiling - A novel tool for mapping the protein modification landscape in cancer. Experimental Biology and Medicine (Maywood, N.J.). PMID 27229346 DOI: 10.1177/1535370216651732  1
2016 Lehmann G, Ziv T, Braten O, Admon A, Udasin RG, Ciechanover A. Ubiquitination of specific mitochondrial matrix proteins. Biochemical and Biophysical Research Communications. PMID 27157140 DOI: 10.1016/j.bbrc.2016.04.150  1
2015 Kravtsova-Ivantsiv Y, Ciechanover A. The ubiquitin-proteasome system and activation of NF-κB: involvement of the ubiquitin ligase KPC1 in p105 processing and tumor suppression. Molecular & Cellular Oncology. 2: e1054552. PMID 27308511 DOI: 10.1080/23723556.2015.1054552  0.64
2015 Ciechanover A. The unravelling of the ubiquitin system. Nature Reviews. Molecular Cell Biology. 16: 322-4. PMID 25907614 DOI: 10.1038/nrm3982  1
2015 Kravtsova-Ivantsiv Y, Shomer I, Cohen-Kaplan V, Snijder B, Superti-Furga G, Gonen H, Sommer T, Ziv T, Admon A, Naroditsky I, Jbara M, Brik A, Pikarsky E, Kwon YT, Doweck I, ... Ciechanover A, et al. KPC1-mediated ubiquitination and proteasomal processing of NF-κB1 p105 to p50 restricts tumor growth. Cell. 161: 333-47. PMID 25860612 DOI: 10.1016/j.cell.2015.03.001  1
2015 Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, ... ... Ciechanover A, et al. Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death and Differentiation. 22: 58-73. PMID 25236395 DOI: 10.1038/cdd.2014.137  1
2014 Ahmed Q, Avidan AY, Ciechanover A, Shechtman D, Zajfman D, Reichman U, Kornberg R, Hershko A, Lavie P. Israel-Gaza conflict. Lancet (London, England). 384: e34-7. PMID 25145777 DOI: 10.1016/S0140-6736(14)61314-3  1
2014 Queisser MA, Dada LA, Deiss-Yehiely N, Angulo M, Zhou G, Kouri FM, Knab LM, Liu J, Stegh AH, DeCamp MM, Budinger GR, Chandel NS, Ciechanover A, Iwai K, Sznajder JI. HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth. American Journal of Respiratory and Critical Care Medicine. 190: 688-98. PMID 25118570 DOI: 10.1164/rccm.201403-0463OC  1
2014 Rossi M, Rotblat B, Ansell K, Amelio I, Caraglia M, Misso G, Bernassola F, Cavasotto CN, Knight RA, Ciechanover A, Melino G. High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy. Cell Death & Disease. 5: e1203. PMID 24787015 DOI: 10.1038/cddis.2014.113  1
2014 Belogurov A, Kudriaeva A, Kuzina E, Smirnov I, Bobik T, Ponomarenko N, Kravtsova-Ivantsiv Y, Ciechanover A, Gabibov A. Multiple sclerosis autoantigen myelin basic protein escapes control by ubiquitination during proteasomal degradation. The Journal of Biological Chemistry. 289: 17758-66. PMID 24739384 DOI: 10.1074/jbc.M113.544247  1
2014 Hemantha HP, Bavikar SN, Herman-Bachinsky Y, Haj-Yahya N, Bondalapati S, Ciechanover A, Brik A. Nonenzymatic polyubiquitination of expressed proteins. Journal of the American Chemical Society. 136: 2665-73. PMID 24437386 DOI: 10.1021/ja412594d  1
2014 Ciechanover A, Stanhill A. The complexity of recognition of ubiquitinated substrates by the 26S proteasome. Biochimica Et Biophysica Acta. 1843: 86-96. PMID 23872423 DOI: 10.1016/j.bbamcr.2013.07.007  1
2013 Haj-Yahya M, Fauvet B, Herman-Bachinsky Y, Hejjaoui M, Bavikar SN, Karthikeyan SV, Ciechanover A, Lashuel HA, Brik A. Synthetic polyubiquitinated α-Synuclein reveals important insights into the roles of the ubiquitin chain in regulating its pathophysiology. Proceedings of the National Academy of Sciences of the United States of America. 110: 17726-31. PMID 24043770 DOI: 10.1073/pnas.1315654110  1
2013 Haj-Yahya N, Haj-Yahya M, Castañeda CA, Spasser L, Hemantha HP, Jbara M, Penner M, Ciechanover A, Fushman D, Brik A. Modifying the vicinity of the isopeptide bond to reveal differential behavior of ubiquitin chains with interacting proteins: organic chemistry applied to synthetic proteins. Angewandte Chemie (International Ed. in English). 52: 11149-53. PMID 24006204 DOI: 10.1002/anie.201306118  1
2013 Bagola K, von Delbrück M, Dittmar G, Scheffner M, Ziv I, Glickman MH, Ciechanover A, Sommer T. Ubiquitin binding by a CUE domain regulates ubiquitin chain formation by ERAD E3 ligases. Molecular Cell. 50: 528-39. PMID 23665229 DOI: 10.1016/j.molcel.2013.04.005  1
2013 Ciechanover A. Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Bioorganic & Medicinal Chemistry. 21: 3400-10. PMID 23485445 DOI: 10.1016/j.bmc.2013.01.056  1
2013 Kravtsova-Ivantsiv Y, Sommer T, Ciechanover A. The lysine48-based polyubiquitin chain proteasomal signal: not a single child anymore. Angewandte Chemie (International Ed. in English). 52: 192-8. PMID 23124625 DOI: 10.1002/anie.201205656  1
2012 Sznajder JI, Ciechanover A. Personalized medicine: the road ahead. American Journal of Respiratory and Critical Care Medicine. 186: 945-7. PMID 23155214 DOI: 10.1164/rccm.201210-1772OE  1
2012 Buchsbaum S, Bercovich B, Ziv T, Ciechanover A. Modification of the inflammatory mediator LRRFIP2 by the ubiquitin-like protein FAT10 inhibits its activity during cellular response to LPS. Biochemical and Biophysical Research Communications. 428: 11-6. PMID 23036196 DOI: 10.1016/j.bbrc.2012.09.110  1
2012 Ciechanover A, Hod Y, Hershko A. A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. 1978. Biochemical and Biophysical Research Communications. 425: 565-70. PMID 22925675 DOI: 10.1016/j.bbrc.2012.08.025  1
2012 de Bie P, Ciechanover A. RING1B ubiquitination and stability are regulated by ARF. Biochemical and Biophysical Research Communications. 426: 49-53. PMID 22910419 DOI: 10.1016/j.bbrc.2012.08.030  1
2012 Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A. The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation. Molecular Cell. 48: 87-97. PMID 22902562 DOI: 10.1016/j.molcel.2012.07.011  1
2012 Braten O, Shabek N, Kravtsova-Ivantsiv Y, Ciechanover A. Generation of free ubiquitin chains is up-regulated in stress and facilitated by the HECT domain ubiquitin ligases UFD4 and HUL5. The Biochemical Journal. 444: 611-7. PMID 22497224 DOI: 10.1042/BJ20111840  1
2012 Kravtsova-Ivantsiv Y, Ciechanover A. Non-canonical ubiquitin-based signals for proteasomal degradation. Journal of Cell Science. 125: 539-48. PMID 22389393 DOI: 10.1242/jcs.093567  1
2012 Craxton A, Butterworth M, Harper N, Fairall L, Schwabe J, Ciechanover A, Cohen GM. NOXA, a sensor of proteasome integrity, is degraded by 26S proteasomes by an ubiquitin-independent pathway that is blocked by MCL-1. Cell Death and Differentiation. 19: 1424-34. PMID 22361683 DOI: 10.1038/cdd.2012.16  1
2012 Ciechanover A. Intracellular protein degradation: from a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Neuro-Degenerative Diseases. 10: 7-22. PMID 22327508 DOI: 10.1159/000334283  1
2012 Noy T, Suad O, Taglicht D, Ciechanover A. HUWE1 ubiquitinates MyoD and targets it for proteasomal degradation. Biochemical and Biophysical Research Communications. 418: 408-13. PMID 22277673 DOI: 10.1016/j.bbrc.2012.01.045  1
2012 Buchsbaum S, Bercovich B, Ciechanover A. FAT10 is a proteasomal degradation signal that is itself regulated by ubiquitination. Molecular Biology of the Cell. 23: 225-32. PMID 22072791 DOI: 10.1091/mbc.E11-07-0609  1
2012 Ciechanover A. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Biochimica Et Biophysica Acta. 1824: 3-13. PMID 21435401 DOI: 10.1016/j.bbapap.2011.03.007  1
2011 Nguyen LK, Muñoz-García J, Maccario H, Ciechanover A, Kolch W, Kholodenko BN. Switches, excitable responses and oscillations in the Ring1B/Bmi1 ubiquitination system. Plos Computational Biology. 7: e1002317. PMID 22194680 DOI: 10.1371/journal.pcbi.1002317  1
2011 Ciechanover AJ, Sznajder JI. Innate and adaptive immunity: the 2011 Nobel Prize in Physiology or Medicine. American Journal of Respiratory and Critical Care Medicine. 184: i-ii. PMID 22162893 DOI: 10.1164/rccm.201111-1930ED  1
2011 Ciechanover A, Shoenfeld Y, Shemer J, Eidelman L, Borow M. Response to health in the Occupied Palestinian Territory. Lancet (London, England). 378: e1; author reply e1. PMID 22035555 DOI: 10.1016/S0140-6736(11)61667-X  1
2011 Ciechanover A. On the wings of imagination. Nature. 478: S4. PMID 21993824 DOI: 10.1038/478S4a  1
2011 Weissman AM, Shabek N, Ciechanover A. The predator becomes the prey: regulating the ubiquitin system by ubiquitylation and degradation. Nature Reviews. Molecular Cell Biology. 12: 605-20. PMID 21860393 DOI: 10.1038/nrm3173  1
2011 Kravtsova-Ivantsiv Y, Ciechanover A. Ubiquitination and degradation of proteins. Methods in Molecular Biology (Clifton, N.J.). 753: 335-57. PMID 21604134 DOI: 10.1007/978-1-61779-148-2_23  1
2011 Zoabi M, Sadeh R, de Bie P, Marquez VE, Ciechanover A. PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins. Biochemical and Biophysical Research Communications. 408: 393-8. PMID 21513699 DOI: 10.1016/j.bbrc.2011.04.025  1
2011 Kühnle S, Kogel U, Glockzin S, Marquardt A, Ciechanover A, Matentzoglu K, Scheffner M. Physical and functional interaction of the HECT ubiquitin-protein ligases E6AP and HERC2. The Journal of Biological Chemistry. 286: 19410-6. PMID 21493713 DOI: 10.1074/jbc.M110.205211  1
2011 de Bie P, Ciechanover A. Ubiquitination of E3 ligases: self-regulation of the ubiquitin system via proteolytic and non-proteolytic mechanisms. Cell Death and Differentiation. 18: 1393-402. PMID 21372847 DOI: 10.1038/cdd.2011.16  1
2011 Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, ... Ciechanover A, et al. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Molecular Cell. 41: 529-42. PMID 21362549 DOI: 10.1016/j.molcel.2011.02.015  1
2011 Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A. Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-κB precursor. Advances in Experimental Medicine and Biology. 691: 95-106. PMID 21153313 DOI: 10.1007/978-1-4419-6612-4_10  1
2011 Kashuba E, Yurchenko M, Yenamandra SP, Snopok B, Szekely L, Bercovich B, Ciechanover A, Klein G. Epstein-Barr virus-encoded EBNA-5 forms trimolecular protein complexes with MDM2 and p53 and inhibits the transactivating function of p53. International Journal of Cancer. Journal International Du Cancer. 128: 817-25. PMID 20473904 DOI: 10.1002/ijc.25414  1
2011 Zoabi M, Sadeh R, de Bie P, Marquez VE, Ciechanover A. Corrigendum to "PRAJA1 is a ubiquitin ligase for the polycomb repressive complex 2 proteins" [Biochem. Biophys. Res. Commun. 408 (2011) 393-398] Biochemical and Biophysical Research Communications. 410: 705. DOI: 10.1016/j.bbrc.2011.06.037  1
2010 de Bie P, Zaaroor-Regev D, Ciechanover A. Regulation of the Polycomb protein RING1B ubiquitination by USP7. Biochemical and Biophysical Research Communications. 400: 389-95. PMID 20800574 DOI: 10.1016/j.bbrc.2010.08.082  1
2010 Zaaroor-Regev D, de Bie P, Scheffner M, Noy T, Shemer R, Heled M, Stein I, Pikarsky E, Ciechanover A. Regulation of the polycomb protein Ring1B by self-ubiquitination or by E6-AP may have implications to the pathogenesis of Angelman syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107: 6788-93. PMID 20351251 DOI: 10.1073/pnas.1003108107  1
2010 Ciechanover A. The ubiquitin system: historical perspective. Proceedings of the American Thoracic Society. 7: 11-2. PMID 20160143 DOI: 10.1513/pats.200908-095JS  1
2010 Shabek N, Ciechanover A. Degradation of ubiquitin: the fate of the cellular reaper. Cell Cycle (Georgetown, Tex.). 9: 523-30. PMID 20107325  1
2010 Bernassola F, Ciechanover A, Melino G. The ubiquitin proteasome system and its involvement in cell death pathways. Cell Death and Differentiation. 17: 1-3. PMID 20010850 DOI: 10.1038/cdd.2009.189  1
2010 Kornitzer D, Ciechanover A. Ubiquitination/proteasome Handbook of Cell Signaling, 2/E. 3: 2093-2098. DOI: 10.1016/B978-0-12-374145-5.00255-2  1
2010 Ciechanover A. Intracellular protein degradation: From a vague idea through the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting | La degradación intracelular de proteínas. desde una vaga idea, a través del lisosoma y el sistema ubiquitina-proteosoma a las enfermedades humanas y el blanco de las drogas Medicina. 70: 105-119.  1
2009 Navon A, Ciechanover A. The 26 S proteasome: from basic mechanisms to drug targeting. The Journal of Biological Chemistry. 284: 33713-8. PMID 19812037 DOI: 10.1074/jbc.R109.018481  1
2009 Cohen S, Ciechanover A, Kravtsova-Ivantsiv Y, Lapid D, Lahav-Baratz S. ABIN-1 negatively regulates NF-kappaB by inhibiting processing of the p105 precursor. Biochemical and Biophysical Research Communications. 389: 205-10. PMID 19695220 DOI: 10.1016/j.bbrc.2009.08.074  1
2009 Shabek N, Herman-Bachinsky Y, Ciechanover A. Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation. Proceedings of the National Academy of Sciences of the United States of America. 106: 11907-12. PMID 19581590 DOI: 10.1073/pnas.0905746106  1
2009 Ciechanover A. Interview with Aaron Ciechanover. Biochemical and Biophysical Research Communications. 387: 11-2. PMID 19549505 DOI: 10.1016/j.bbrc.2009.06.093  1
2009 Ciechanover A. Tracing the history of the ubiquitin proteolytic system: the pioneering article. Biochemical and Biophysical Research Communications. 387: 1-10. PMID 19539608 DOI: 10.1016/j.bbrc.2009.06.065  1
2009 Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH, Bazan NG, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Castedo M, Cidlowski JA, Ciechanover A, et al. Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death and Differentiation. 16: 1093-107. PMID 19373242 DOI: 10.1038/cdd.2009.44  1
2009 Lecuona E, Sun H, Vohwinkel C, Ciechanover A, Sznajder JI. Ubiquitination participates in the lysosomal degradation of Na,K-ATPase in steady-state conditions. American Journal of Respiratory Cell and Molecular Biology. 41: 671-9. PMID 19286978 DOI: 10.1165/rcmb.2008-0365OC  1
2009 Kravtsova-Ivantsiv Y, Cohen S, Ciechanover A. Modification by single ubiquitin moieties rather than polyubiquitination is sufficient for proteasomal processing of the p105 NF-kappaB precursor. Molecular Cell. 33: 496-504. PMID 19250910 DOI: 10.1016/j.molcel.2009.01.023  1
2009 Schwartz AL, Ciechanover A. Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology. Annual Review of Pharmacology and Toxicology. 49: 73-96. PMID 18834306 DOI: 10.1146/annurev.pharmtox.051208.165340  1
2008 Sadeh R, Breitschopf K, Bercovich B, Zoabi M, Kravtsova-Ivantsiv Y, Kornitzer D, Schwartz A, Ciechanover A. The N-terminal domain of MyoD is necessary and sufficient for its nuclear localization-dependent degradation by the ubiquitin system. Proceedings of the National Academy of Sciences of the United States of America. 105: 15690-5. PMID 18836078 DOI: 10.1073/pnas.0808373105  1
2008 Jaitovich A, Mehta S, Na N, Ciechanover A, Goldman RD, Ridge KM. Ubiquitin-proteasome-mediated degradation of keratin intermediate filaments in mechanically stimulated A549 cells. The Journal of Biological Chemistry. 283: 25348-55. PMID 18617517 DOI: 10.1074/jbc.M801635200  1
2008 Bernassola F, Karin M, Ciechanover A, Melino G. The HECT family of E3 ubiquitin ligases: multiple players in cancer development. Cancer Cell. 14: 10-21. PMID 18598940 DOI: 10.1016/j.ccr.2008.06.001  1
2008 Melino G, Gallagher E, Aqeilan RI, Knight R, Peschiaroli A, Rossi M, Scialpi F, Malatesta M, Zocchi L, Browne G, Ciechanover A, Bernassola F. Itch: a HECT-type E3 ligase regulating immunity, skin and cancer. Cell Death and Differentiation. 15: 1103-12. PMID 18552861 DOI: 10.1038/cdd.2008.60  1
2008 Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL. In vivo interactions of MyoD, Id1, and E2A proteins determined by acceptor photobleaching fluorescence resonance energy transfer. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1694-701. PMID 18198216 DOI: 10.1096/fj.07-095000  1
2008 Zhou G, Dada LA, Chandel NS, Iwai K, Lecuona E, Ciechanover A, Sznajder JI. Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 1335-42. PMID 18073334 DOI: 10.1096/fj.07-8369com  1
2008 Mayer RJ, Ciechanover AJ, Rechsteiner M. Protein Degradation Protein Degradation. 2: 1-286. DOI: 10.1002/9783527620210  1
2007 Ciechanover A. Intracellular protein degradation from a vague idea through the lysosome and the ubiquitin-proteasome system and on to human diseases and drug targeting: Nobel Lecture, December 8, 2004. Annals of the New York Academy of Sciences. 1116: 1-28. PMID 18083918 DOI: 10.1196/annals.1402.078  1
2007 Shabek N, Iwai K, Ciechanover A. Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target. Biochemical and Biophysical Research Communications. 363: 425-31. PMID 17870054 DOI: 10.1016/j.bbrc.2007.08.185  1
2007 Dada LA, Welch LC, Zhou G, Ben-Saadon R, Ciechanover A, Sznajder JI. Phosphorylation and ubiquitination are necessary for Na,K-ATPase endocytosis during hypoxia. Cellular Signalling. 19: 1893-8. PMID 17532187 DOI: 10.1016/j.cellsig.2007.04.013  1
2007 Herman-Bachinsky Y, Ryoo HD, Ciechanover A, Gonen H. Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways. Cell Death and Differentiation. 14: 861-71. PMID 17205079 DOI: 10.1038/sj.cdd.4402079  1
2007 Sun L, Trausch-Azar JS, Ciechanover A, Schwartz AL. E2A protein degradation by the ubiquitin-proteasome system is stage-dependent during muscle differentiation. Oncogene. 26: 441-8. PMID 16909127 DOI: 10.1038/sj.onc.1209793  1
2007 Mayer RJ, Ciechanover AJ, Rechsteiner M. Protein Degradation: Cell Biology of the Ubiquitin-Proteasome System, Volume 3 Protein Degradation: Cell Biology of the Ubiquitin-Proteasome System, Volume 3. 1-238. DOI: 10.1002/9783527620227  1
2007 Ciechanover A. N-terminal Ubiquitination: No Longer Such a Rare Modification Protein Degradation. 1: 10-20. DOI: 10.1002/9783527619320.ch2  1
2007 Ciechanover AJ, Rechsteiner M, Mayer RJ. Preface Protein Degradation. 1: xiii-xiv. DOI: 10.1002/9783527619320  1
2006 Ben-Saadon R, Zaaroor D, Ziv T, Ciechanover A. The polycomb protein Ring1B generates self atypical mixed ubiquitin chains required for its in vitro histone H2A ligase activity. Molecular Cell. 24: 701-11. PMID 17157253 DOI: 10.1016/j.molcel.2006.10.022  1
2006 Ciechanover A. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 1-12, 505-6. PMID 17124032 DOI: 10.1182/asheducation-2006.1.1  1
2006 Reinstein E, Ciechanover A. Narrative review: protein degradation and human diseases: the ubiquitin connection. Annals of Internal Medicine. 145: 676-84. PMID 17088581  1
2006 Goodman SR, Ciechanover AJ, Hulse RA, Feng da H, Fluckiger S. Nobel round-table discussion #1: the future of interdisciplinary research and training. Experimental Biology and Medicine (Maywood, N.J.). 231: 1225-39. PMID 16816128  1
2006 Ciechanover A. Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting. Experimental Biology and Medicine (Maywood, N.J.). 231: 1197-211. PMID 16816126  1
2006 Cohen S, Lahav-Baratz S, Ciechanover A. Two distinct ubiquitin-dependent mechanisms are involved in NF-kappaB p105 proteolysis. Biochemical and Biophysical Research Communications. 345: 7-13. PMID 16678126 DOI: 10.1016/j.bbrc.2006.04.036  1
2006 Comellas AP, Dada LA, Lecuona E, Pesce LM, Chandel NS, Quesada N, Budinger GR, Strous GJ, Ciechanover A, Sznajder JI. Hypoxia-mediated degradation of Na,K-ATPase via mitochondrial reactive oxygen species and the ubiquitin-conjugating system. Circulation Research. 98: 1314-22. PMID 16614303 DOI: 10.1161/01.RES.0000222418.99976.1d  1
2006 Ciechanover A. The ubiquitin proteolytic system: from an idea to the patient bed. Proceedings of the American Thoracic Society. 3: 21-31. PMID 16493148 DOI: 10.1513/pats.200510-106JH  1
2006 Ciechanover A. The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting. Neurology. 66: S7-19. PMID 16432150 DOI: 10.1212/01.wnl.0000192261.02023.b8  1
2006 Ciechanover A. Intracellular protein degradation: From a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting: Nobel lecture Israel Journal of Chemistry. 46: 121-136. DOI: 10.1560/380V-VWLX-XDRT-CB7K  1
2006 Ciechanover A. Methods in Protein Ubiquitination Cell Biology, Four-Volume Set. 4: 351-360. DOI: 10.1016/B978-012164730-8/50230-6  1
2005 Ciechanover A. Intracellular protein degradation: from a vague idea, through the lysosome and the ubiquitin-proteasome system, and onto human diseases and drug targeting (Nobel lecture). Angewandte Chemie (International Ed. in English). 44: 5944-67. PMID 16142822 DOI: 10.1002/anie.200501428  1
2005 Ciechanover A. Early work on the ubiquitin proteasome system, an interview with Aaron Ciechanover. Interview by CDD. Cell Death and Differentiation. 12: 1167-77. PMID 16094393 DOI: 10.1038/sj.cdd.4401691  1
2005 Herrmann J, Ciechanover A, Lerman LO, Lerman A. The ubiquitin-proteasome system--micro target for macro intervention? International Journal of Cardiovascular Interventions. 7: 5-13. PMID 16019609 DOI: 10.1080/14628840510011234  1
2005 Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL. E12 and E47 modulate cellular localization and proteasome-mediated degradation of MyoD and Id1. Oncogene. 24: 6376-84. PMID 16007194 DOI: 10.1038/sj.onc.1208789  1
2005 Ciechanover A. N-terminal ubiquitination. Methods in Molecular Biology (Clifton, N.J.). 301: 255-70. PMID 15917637 DOI: 10.1385/1-59259-895-1:255  1
2005 Sun L, Trausch-Azar JS, Ciechanover A, Schwartz AL. Ubiquitin-proteasome-mediated degradation, intracellular localization, and protein synthesis of MyoD and Id1 during muscle differentiation. The Journal of Biological Chemistry. 280: 26448-56. PMID 15888449 DOI: 10.1074/jbc.M500373200  1
2005 Lotan R, Rotem A, Gonen H, Finberg JP, Kemeny S, Steller H, Ciechanover A, Larisch S. Regulation of the proapoptotic ARTS protein by ubiquitin-mediated degradation. The Journal of Biological Chemistry. 280: 25802-10. PMID 15837787 DOI: 10.1074/jbc.M501955200  1
2005 Ciechanover A. Proteolysis: from the lysosome to ubiquitin and the proteasome. Nature Reviews. Molecular Cell Biology. 6: 79-87. PMID 15688069 DOI: 10.1038/nrm1552  1
2005 Mayer RJ, Ciechanover A, Rechsteiner M. Protein Degradation: Ubiquitin and the Chemistry of Life Protein Degradation: Ubiquitin and the Chemistry of Life. 1: 1-377. DOI: 10.1002/352760586X  1
2004 Ciechanover A, Schwartz AL. The ubiquitin system: pathogenesis of human diseases and drug targeting. Biochimica Et Biophysica Acta. 1695: 3-17. PMID 15571805 DOI: 10.1016/j.bbamcr.2004.09.018  1
2004 Ben-Saadon R, Fajerman I, Ziv T, Hellman U, Schwartz AL, Ciechanover A. The tumor suppressor protein p16(INK4a) and the human papillomavirus oncoprotein-58 E7 are naturally occurring lysine-less proteins that are degraded by the ubiquitin system. Direct evidence for ubiquitination at the N-terminal residue. The Journal of Biological Chemistry. 279: 41414-21. PMID 15254040 DOI: 10.1074/jbc.M407201200  1
2004 Ciechanover A, Iwai K. The ubiquitin system: from basic mechanisms to the patient bed. Iubmb Life. 56: 193-201. PMID 15230346 DOI: 10.1080/1521654042000223616  1
2004 Lahav-Baratz S, Ben-Izhak O, Sabo E, Ben-Eliezer S, Lavie O, Ishai D, Ciechanover A, Dirnfeld M. Decreased level of the cell cycle regulator p27 and increased level of its ubiquitin ligase Skp2 in endometrial carcinoma but not in normal secretory or in hyperstimulated endometrium. Molecular Human Reproduction. 10: 567-72. PMID 15220466 DOI: 10.1093/molehr/gah084  1
2004 Trausch-Azar JS, Lingbeck J, Ciechanover A, Schwartz AL. Ubiquitin-Proteasome-mediated degradation of Id1 is modulated by MyoD. The Journal of Biological Chemistry. 279: 32614-9. PMID 15163661 DOI: 10.1074/jbc.M403794200  1
2004 Sun XM, Butterworth M, MacFarlane M, Dubiel W, Ciechanover A, Cohen GM. Caspase activation inhibits proteasome function during apoptosis. Molecular Cell. 14: 81-93. PMID 15068805 DOI: 10.1016/S1097-2765(04)00156-X  1
2004 Finley D, Ciechanover A, Varshavsky A. Ubiquitin as a central cellular regulator. Cell. 116: S29-32, 2 p followin. PMID 15055578  1
2004 Ciechanover A, Ben-Saadon R. N-terminal ubiquitination: more protein substrates join in. Trends in Cell Biology. 14: 103-6. PMID 15055197 DOI: 10.1016/j.tcb.2004.01.004  1
2004 Fajerman I, Schwartz AL, Ciechanover A. Degradation of the Id2 developmental regulator: targeting via N-terminal ubiquitination. Biochemical and Biophysical Research Communications. 314: 505-12. PMID 14733935 DOI: 10.1016/j.bbrc.2003.12.116  1
2004 Herrmann J, Ciechanover A, Lerman LO, Lerman A. The ubiquitin-proteasome system in cardiovascular diseases-a hypothesis extended. Cardiovascular Research. 61: 11-21. PMID 14732197 DOI: 10.1016/j.cardiores.2003.09.033  1
2004 Amir RE, Haecker H, Karin M, Ciechanover A. Mechanism of processing of the NF-kappa B2 p100 precursor: identification of the specific polyubiquitin chain-anchoring lysine residue and analysis of the role of NEDD8-modification on the SCF(beta-TrCP) ubiquitin ligase. Oncogene. 23: 2540-7. PMID 14676825 DOI: 10.1038/sj.onc.1207366  1
2004 Cohen S, Achbert-Weiner H, Ciechanover A. Dual effects of IkappaB kinase beta-mediated phosphorylation on p105 Fate: SCF(beta-TrCP)-dependent degradation and SCF(beta-TrCP)-independent processing. Molecular and Cellular Biology. 24: 475-86. PMID 14673179  0.96
2004 Cohen S, Achbert-Weiner H, Ciechanover A. Dual Effects of IκB Kinase β-Mediated Phosphorylation on p105 Fate: SCβ-TrCP-Dependent Degradation and SCFβ -TrCP-Independent Processing Molecular and Cellular Biology. 24: 475-486. DOI: 10.1128/MCB.24.1.475-486.2004  1
2003 Ciechanover A, Brundin P. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron. 40: 427-46. PMID 14556719 DOI: 10.1016/S0896-6273(03)00606-8  1
2003 Linares LK, Hengstermann A, Ciechanover A, Müller S, Scheffner M. HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53. Proceedings of the National Academy of Sciences of the United States of America. 100: 12009-14. PMID 14507994 DOI: 10.1073/pnas.2030930100  1
2003 Hermann J, Gulati R, Napoli C, Woodrum JE, Lerman LO, Rodriguez-Porcel M, Sica V, Simari RD, Ciechanover A, Lerman A. Oxidative stress-related increase in ubiquitination in early coronary atherogenesis. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 1730-2. PMID 12958191 DOI: 10.1096/fj.02-0841fje  1
2003 Ben-Izhak O, Lahav-Baratz S, Meretyk S, Ben-Eliezer S, Sabo E, Dirnfeld M, Cohen S, Ciechanover A. Inverse relationship between Skp2 ubiquitin ligase and the cyclin dependent kinase inhibitor p27Kip1 in prostate cancer. The Journal of Urology. 170: 241-5. PMID 12796697 DOI: 10.1097/01.ju.0000072113.34524.a7  1
2003 Ciechanover A. The ubiquitin proteolytic system and pathogenesis of human diseases: A novel platform for mechanism-based drug targeting Biochemical Society Transactions. 31: 474-481. PMID 12653666 DOI: 10.1042/BST0310474  1
2003 Nadav E, Shmueli A, Barr H, Gonen H, Ciechanover A, Reiss Y. A novel mammalian endoplasmic reticulum ubiquitin ligase homologous to the yeast Hrd1. Biochemical and Biophysical Research Communications. 303: 91-7. PMID 12646171 DOI: 10.1016/S0006-291X(03)00279-1  1
2003 Lingbeck JM, Trausch-Azar JS, Ciechanover A, Schwartz AL. Determinants of nuclear and cytoplasmic ubiquitin-mediated degradation of MyoD. The Journal of Biological Chemistry. 278: 1817-23. PMID 12397066 DOI: 10.1074/jbc.M208815200  1
2003 Ciechanover A. Introduction and overview Seminars in Cancer Biology. 13: 1-4. DOI: 10.1016/S1043-6618(02)00203-7  1
2003 Kornitzer D, Ciechanover A. Proteasome/Ubiquitination Handbook of Cell Signaling. 3: 129-133. DOI: 10.1016/B978-012124546-7/50652-5  1
2002 Herrmann J, Edwards WD, Holmes DR, Shogren KL, Lerman LO, Ciechanover A, Lerman A. Increased ubiquitin immunoreactivity in unstable atherosclerotic plaques associated with acute coronary syndromes. Journal of the American College of Cardiology. 40: 1919-27. PMID 12475450 DOI: 10.1016/S0735-1097(02)02564-0  1
2002 Ryoo HD, Bergmann A, Gonen H, Ciechanover A, Steller H. Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1. Nature Cell Biology. 4: 432-8. PMID 12021769 DOI: 10.1038/ncb795  1
2002 Amir RE, Iwai K, Ciechanover A. The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105. The Journal of Biological Chemistry. 277: 23253-9. PMID 11953428 DOI: 10.1074/jbc.M200967200  1
2002 Glickman MH, Ciechanover A. The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction. Physiological Reviews. 82: 373-428. PMID 11917093 DOI: 10.1152/physrev.00027.2001  1
2002 Ciechanover A, Schwartz AL. Ubiquitin-mediated degradation of cellular proteins in health and disease. Hepatology (Baltimore, Md.). 35: 3-6. PMID 11786953 DOI: 10.1053/jhep.2002.30316  1
2001 Amir R, Ciechanover A, Cohen S. The ubiquitin-proteasome system: the relationship between protein degradation and human diseases Harefuah. 140: 1172-1176, 1229. PMID 11789303  1
2001 Ciechanover A. Linking ubiquitin, parkin and synphilin-1 Nature Medicine. 7: 1108-1109. PMID 11590431 DOI: 10.1038/nm1001-1108  1
2001 Sionov RV, Coen S, Goldberg Z, Berger M, Bercovich B, Ben-Neriah Y, Ciechanover A, Haupt Y. c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination. Molecular and Cellular Biology. 21: 5869-78. PMID 11486026 DOI: 10.1128/MCB.21.17.5869-5878.2001  1
2001 Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, Ciechanover A, Israël A. Functional Interaction between SEL-10, an F-box Protein, and the Nuclear Form of Activated Notch1 Receptor Journal of Biological Chemistry. 276: 34371-34378. PMID 11425854 DOI: 10.1074/jbc.M101343200  1
2001 Ciechanover A. Ubiquitin-mediated degradation of cellular proteins: Why destruction is essential for construction, and how it got from the test tube to the patient's bed Israel Medical Association Journal. 3: 319-327. PMID 11411194  1
2001 Cohen S, Orian A, Ciechanover A. Processing of p105 Is Inhibited by Docking of p50 Active Subunits to the Ankyrin Repeat Domain, and Inhibition Is Alleviated by Signaling via the Carboxyl-terminal Phosphorylation/Ubiquitin-Ligase Binding Domain Journal of Biological Chemistry. 276: 26769-26776. PMID 11350967 DOI: 10.1074/jbc.M102448200  1
2001 Floyd ZE, Trausch-Azar JS, Reinstein E, Ciechanover A, Schwartz AL. The Nuclear Ubiquitin-Proteasome System Degrades MyoD Journal of Biological Chemistry. 276: 22468-22475. PMID 11309375 DOI: 10.1074/jbc.M009388200  1
2001 Ciechanover A, Gonen H, Bercovich B, Cohen S, Fajerman I, Israël A, Mercurio F, Kahana C, Schwartz AL, Iwai K, Orian A. Mechanisms of ubiquitin-mediated, limited processing of the NF-κB1 precursor protein p105 Biochimie. 83: 341-349. PMID 11295495 DOI: 10.1016/S0300-9084(01)01239-1  1
2001 Hengstermann A, Linares LK, Ciechanover A, Whitaker NJ, Scheffner M. Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 1218-23. PMID 11158620 DOI: 10.1073/pnas.031470698  1
2000 Reinstein E, Scheffner M, Oren M, Ciechanover A, Schwartz A. Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: Targeting via ubiquitination of the N-terminal residue Oncogene. 19: 5944-5950. PMID 11127826 DOI: 10.1038/sj.onc.1203989  1
2000 Hershko A, Ciechanover A, Varshavsky A. Basic Medical Research Award. The ubiquitin system. Nature Medicine. 6: 1073-81. PMID 11017125 DOI: 10.1038/80384  1
2000 Orian A, Gonen H, Bercovich B, Fajerman I, Eytan E, Israël A, Mercurio F, Iwai K, Schwartz AL, Ciechanover A. SCF(β-TrCP) ubiquitin ligase-mediated processing of NF-κB p105 requires phosphorylation of its C-terminus by IκB kinase Embo Journal. 19: 2580-2591. PMID 10835356  1
2000 Aviel S, Winberg G, Massucci M, Ciechanover A. Degradation of the Epstein-Barr virus latent membrane protein 1 (LMP1) by the ubiquitin-proteasome pathway: Targeting via ubiquitination of the N-terminal residue Journal of Biological Chemistry. 275: 23491-23499. PMID 10807912 DOI: 10.1074/jbc.M002052200  1
2000 Sadot E, Simcha I, Iwai K, Ciechanover A, Geiger B, Ben-Ze'ev A. Differential interaction of plakoglobin and β-catenin with the ubiquitin-proteasome system Oncogene. 19: 1992-2001. PMID 10803460  1
2000 Ciechanover A, Orian A, Schwartz AL. Ubiquitin-mediated proteolysis: Biological regulation via destruction Bioessays. 22: 442-451. PMID 10797484 DOI: 10.1002/(SICI)1521-1878(200005)22:5<442::AID-BIES6>3.0.CO;2-Q  1
2000 Ciechanover A, Orian A, Schwartz AL. The ubiquitin-mediated proteolytic pathway: Mode of action and clinical implications Journal of Cellular Biochemistry. 77: 40-51. PMID 10762014 DOI: 10.1002/(SICI)1097-4644(2000)77:34+<40::AID-JCB9>3.0.CO;2-6  1
2000 Kornitzer D, Ciechanover A. Modes of regulation of ubiquitin-mediated protein degradation Journal of Cellular Physiology. 182: 1-11. PMID 10567911  1
1999 Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I, Lavi S, Iwai K, Reiss Y, Ciechanover A, Lipkowitz S, Yarden Y. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1 Molecular Cell. 4: 1029-1040. PMID 10635327  1
1999 Cummings CJ, Reinstein E, Sun Y, Antalffy B, Jiang Y, Ciechanover A, Orr HT, Beaudet AL, Zoghbi HY. Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron. 24: 879-92. PMID 10624951  1
1999 Ciechanover A, Breitschopf K, Abu Hatoum O, Bengal E. Degradation of MyoD by the ubiquitin pathway: Regulation by specific DNA-binding and identification of a novel site for ubiquitination Molecular Biology Reports. 26: 59-64. PMID 10363648  1
1999 Gonen H, Bercovich B, Orian A, Carrano A, Takizawa C, Yamanaka K, Pagano M, Iwai K, Ciechanover A. Identification of the ubiquitin carrier proteins, E2s, involved in signal-induced conjugation and subsequent degradation of IκBα Journal of Biological Chemistry. 274: 14823-14830. PMID 10329681 DOI: 10.1074/jbc.274.21.14823  1
1999 Orian A, Schwartz AL, Israël A, Whiteside S, Kahana C, Ciechanover A. Structural motifs involved in ubiquitin-mediated processing of the NF- κB precursor p105: Roles of the Glycine-rich region and a downstream ubiquitination domain Molecular and Cellular Biology. 19: 3664-3673. PMID 10207090  1
1999 Schwartz AL, Ciechanover A. The ubiquitin-proteasome pathway and pathogenesis of human diseases Annual Review of Medicine. 50: 57-74. PMID 10073263 DOI: 10.1146/annurev.med.50.1.57  1
1998 Ciechanover A. The ubiquitin-proteasome pathway: On protein death and cell life Embo Journal. 17: 7151-7160. PMID 9857172 DOI: 10.1093/emboj/17.24.7151  1
1998 Breitschopf K, Bengal E, Ziv T, Admon A, Ciechanover A. A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. The Embo Journal. 17: 5964-73. PMID 9774340 DOI: 10.1093/emboj/17.20.5964  1
1998 Hershko A, Ciechanover A. The ubiquitin system. Annual Review of Biochemistry. 67: 425-79. PMID 9759494 DOI: 10.1146/annurev.biochem.67.1.425  1
1998 Hatoum OA, Gross-Mesilaty S, Breitschopf K, Hoffman A, Gonen H, Ciechanover A, Bengal E. Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: Regulation by specific DNA binding Molecular and Cellular Biology. 18: 5670-5677. PMID 9742084  1
1998 Gross-Mesilaty S, Reinstein E, Bercovich B, Tobias KE, Schwartz AL, Kahana C, Ciechanover A. Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway Proceedings of the National Academy of Sciences of the United States of America. 95: 8058-8063. PMID 9653139 DOI: 10.1073/pnas.95.14.8058  1
1998 Ciechanover A, Schwartz AL. The ubiquitin-proteasome pathway: The complexity and myriad functions of proteins death Proceedings of the National Academy of Sciences of the United States of America. 95: 2727-2730. PMID 9501156 DOI: 10.1073/pnas.95.6.2727  1
1998 Sancho E, Vilá MR, Sánchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, et al. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells Molecular and Cellular Biology. 18: 576-589. PMID 9418904  1
1997 Levitskaya J, Sharipo A, Leonchiks A, Ciechanover A, Masucci MG. Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1 Proceedings of the National Academy of Sciences of the United States of America. 94: 12616-12621. PMID 9356498 DOI: 10.1073/pnas.94.23.12616  1
1997 Yaron A, Gonen H, Alkalay I, Hatzubai A, Jung S, Beyth S, Mercurio F, Manning AM, Ciechanover A, Ben-Neriah Y. Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase. The Embo Journal. 16: 6486-94. PMID 9351830 DOI: 10.1093/emboj/16.21.6486  1
1997 Staub O, Gautschi I, Ishikawa T, Breitschopf K, Ciechanover A, Schild L, Rotin D. Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination Embo Journal. 16: 6325-6336. PMID 9351815 DOI: 10.1093/emboj/16.21.6325  1
1997 Ciechanover A, Hargrove JL, Gross-Mesilaty S. Ubiquitin-mediated degradation of tyrosine aminotransferase (TAT) in vitro and in vivo Molecular Biology Reports. 24: 27-33. PMID 9228277  1
1997 Gonen H, Shkedy D, Barnoy S, Kosower NS, Ciechanover A. On the involvement of calpains in the degradation of the tumor suppressor protein p53 Febs Letters. 406: 17-22. PMID 9109377 DOI: 10.1016/S0014-5793(97)00225-1  1
1997 Stephen AG, Trausch-Azar JS, Handley-Gearhart PM, Ciechanover A, Schwartz AL. Identification of a region within the ubiquitin-activating enzyme required for nuclear targeting and phosphorylation Journal of Biological Chemistry. 272: 10895-10903. PMID 9099746 DOI: 10.1074/jbc.272.16.10895  1
1997 Gross-Mesilaty S, Hargrove JL, Ciechanover A. Degradation of tyrosine aminotransferase (TAT) via the ubiquitin-proteasome pathway Febs Letters. 405: 175-180. PMID 9089286 DOI: 10.1016/S0014-5793(97)00181-6  1
1997 Bercovich B, Stancovski I, Mayer A, Blumenfeld N, Laszlo A, Schwartz AL, Ciechanover A. Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70 Journal of Biological Chemistry. 272: 9002-9010. PMID 9083024 DOI: 10.1074/jbc.272.14.9002  1
1996 Wöstmann C, Liakopoulos D, Ciechanover A, Bakker-Grunwald T. Characterization of ubiquitin genes and -transcripts and demonstration of a ubiquitin-conjugating system in Entamoeba histolytica Molecular and Biochemical Parasitology. 82: 81-90. PMID 8943152 DOI: 10.1016/0166-6851(96)02725-9  1
1996 Ciechanover A. Ubiquitin-mediated proteolysis and male sterility Nature Medicine. 2: 1188-1190. PMID 8898739 DOI: 10.1038/nm1196-1188  1
1996 Gonen H, Dickman D, Schwartz AL, Ciechanover A. Protein synthesis elongation factor EF-1α is an isopeptidase essential for ubiquitin-dependent degradation of certain proteolytic substrates Advances in Experimental Medicine and Biology. 389: 209-219. PMID 8861013  1
1996 Strous GJ, Van Kerkhof P, Govers R, Ciechanover A, Schwartz AL. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor Embo Journal. 15: 3806-3812. PMID 8670885  1
1996 Stephen AG, Trausch-Azar JS, Ciechanover A, Schwartz AL. The ubiquitin-activating enzyme E1 is phosphorylated and localized to the nucleus in a cell cycle-dependent manner Journal of Biological Chemistry. 271: 15608-15614. PMID 8663123 DOI: 10.1074/jbc.271.26.15608  1
1996 Gronen H, Stancovski I, Shkedy D, Hadari T, Bercovich B, Bengal E, Mesilati S, Abu-Hatoum O, Schwartz AL, Ciechanover A. Isolation, characterization, and partial purification of a novel ubiquitin-protein ligase, E3: Taegeting of protein substrates via multiple and distinct recognition signals and conjugating enzymes Journal of Biological Chemistry. 271: 302-310. PMID 8550577  1
1995 Ciechanover A, Laszlo A, Bercovich B, Stancovski I, Alkalay I, Ben-Neriah Y, Orian A. The ubiquitin-mediated proteolytic system: involvement of molecular chaperones, degradation of oncoproteins, and activation of transcriptional regulators. Cold Spring Harbor Symposia On Quantitative Biology. 60: 491-501. PMID 8824422  1
1995 Stancovski I, Gonen H, Orian A, Schwartz AL, Ciechanover A. Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: Identification and characterization of the conjugating enzymes Molecular and Cellular Biology. 15: 7106-7116. PMID 8524278  1
1995 Elias S, Bercovich B, Kahana C, Coffino P, Fischer M, Hilt W, Wolf DH, Ciechanover A. Degradation of ornithine decarboxylase by the mammalian and yeast 26S proteasome complexes requires all the components of the protease European Journal of Biochemistry. 229: 276-283. PMID 7744041 DOI: 10.1111/j.1432-1033.1995.0276l.x  1
1995 Orian A, Whiteside S, Israël A, Stancovski I, Schwartz AL, Ciechanover A. Ubiquitin-mediated processing of NF-κB transcriptional activator precursor p105: Reconstitution of a cell-free system and identification of the ubiquitin-carrier protein, E2, and a novel ubiquitin-protein ligase, E3, involved in conjugation Journal of Biological Chemistry. 270: 21707-21714. PMID 7665588  1
1995 Alkalay I, Yaron A, Hatzubai A, Orian A, Ciechanover A, Ben-Neriah Y. Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proceedings of the National Academy of Sciences of the United States of America. 92: 10599-603. PMID 7479848 DOI: 10.1073/pnas.92.23.10599  1
1994 Ciechanover A, Shkedy D, Oren M, Bercovich B. Degradation of the tumor suppressor protein p53 by the ubiquitin-mediated proteolytic system requires a novel species of ubiquitin-carrier protein, E2 Journal of Biological Chemistry. 269: 9582-9589. PMID 8144545  1
1994 Blumenfeld N, Gonen H, Mayer A, Smith CE, Siegel NR, Schwartz AL, Ciechanover A. Purification and characterization of a novel species of ubiquitin-carrier protein, E2, that is involved in degradation of non-"N-end rule" protein substrates Journal of Biological Chemistry. 269: 9574-9581. PMID 8144544  1
1994 Ciechanover A, Schwartz AL. The ubiquitin-mediated proteolytic pathway: Mechanisms of recognition of the proteolytic substrate and involvement in the degradation of native cellular proteins Faseb Journal. 8: 182-191. PMID 8119489  1
1994 Gonen H, Smith CE, Siegel NR, Kahana C, Merrick WC, Chakraburtty K, Schwartz AL, Ciechanover A. Protein synthesis elongation factor EF-1α is essential for ubiquitin-dependent degradation of certain Nα-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu Proceedings of the National Academy of Sciences of the United States of America. 91: 7648-7652. PMID 8052636  1
1994 Shkedy D, Gonen H, Bercovich B, Ciechanover A. Complete reconstitution of conjugation and subsequent degradation of the tumor suppressor protein p53 by purified components of the ubiquitin proteolytic system Febs Letters. 348: 126-130. PMID 8034027 DOI: 10.1016/0014-5793(94)00582-6  1
1994 Grenfell SJ, Trausch-Azar JS, Handley-Gearhart PM, Ciechanover A, Schwartz AL. Nuclear localization of the ubiquitin-activating enzyme, E1, is cell-cycle-dependent Biochemical Journal. 300: 701-708. PMID 8010951  1
1994 Fischer M, Hilt W, Richter-Ruoff B, Gonen H, Ciechanover A, Wolf DH. The 26S proteasome of the yeast Saccharomyces cerevisiae Febs Letters. 355: 69-75. PMID 7957966 DOI: 10.1016/0014-5793(94)01177-X  1
1994 Ciechanover A. The Ubiquitin-Mediated Proteolytic Pathway: Mechanisms of Action and Cellular Physiology Biological Chemistry Hoppe-Seyler. 375: 565-582. PMID 7840898 DOI: 10.1515/bchm3.1994.375.9.565  1
1994 Handley-Gearhart PM, Trausch-Azar JS, Ciechanover A, Schwartz AL. Rescue of the complex temperature-sensitive phenotype of Chinese hamster ovary E36ts20 cells by expression of the human ubiquitin-activating enzyme cDNA Biochemical Journal. 304: 1015-1020. PMID 7818464  1
1994 Handley-Gearhart PM, Stephen AG, Trausch-Azar JS, Ciechanover A, Schwartz AL. Human ubiquitin-activating enzyme, E1: Indication of potential nuclear and cytoplasmic subpopulations using epitope-tagged cDNA constructs Journal of Biological Chemistry. 269: 33171-33178. PMID 7528747  1
1993 Trausch JS, Grenfell SJ, Handley-Gearhart PM, Ciechanover A, Schwartz AL. Immunofluorescent localization of the ubiquitin-activating enzyme, E1, to the nucleus and cytoskeleton American Journal of Physiology - Cell Physiology. 264: C93-C102. PMID 8430776  1
1992 Schwartz AL, Trausch JS, Ciechanover A, Slot JW, Geuze H. Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells Proceedings of the National Academy of Sciences of the United States of America. 89: 5542-5546. PMID 1376922 DOI: 10.1073/pnas.89.12.5542  1
1992 Schwartz AL, Ciechanover A. Ubiquitin-mediated protein modification and degradation American Journal of Respiratory Cell and Molecular Biology. 7: 463-468. PMID 1329865  1
1992 Hershko A, Ciechanover A. The ubiquitin system for protein degradation. Annual Review of Biochemistry. 61: 761-807. PMID 1323239 DOI: 10.1146/annurev.bi.61.070192.003553  1
1992 Lenk SE, Dunn WA, Trausch JS, Ciechanover A, Schwartz AL. Ubiquitin-activating enzyme, E1, is associated with maturation of autophagic vacuoles Journal of Cell Biology. 118: 301-308. PMID 1321157 DOI: 10.1083/jcb.118.2.301  1
1992 Schwartz AL, Brandt RA, Geuze H, Ciechanover A. Stress-induced alterations in autophagic pathway: Relationship to ubiquitin system American Journal of Physiology - Cell Physiology. 262: C1031-C1038. PMID 1314483  1
1988 Ciechanover A, Ferber S, Ganoth D, Elias S, Hershko A, Arfin S. Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway. The Journal of Biological Chemistry. 263: 11155-67. PMID 2841321  1
1986 Hershko A, Ciechanover A. The ubiquitin pathway for the degradation of intracellular proteins. Progress in Nucleic Acid Research and Molecular Biology. 33: 19-56, 301. PMID 3025922  1
1983 Hershko A, Heller H, Elias S, Ciechanover A. Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. The Journal of Biological Chemistry. 258: 8206-14. PMID 6305978  1
1982 Hershko A, Eytan E, Ciechanover A, Haas AL. Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. The Journal of Biological Chemistry. 257: 13964-70. PMID 6292216  1
1982 Hershko A, Ciechanover A. Mechanisms of intracellular protein breakdown. Annual Review of Biochemistry. 51: 335-64. PMID 6287917 DOI: 10.1146/annurev.bi.51.070182.002003  1
1982 Ciechanover A, Elias S, Heller H, Hershko A. "Covalent affinity" purification of ubiquitin-activating enzyme. The Journal of Biological Chemistry. 257: 2537-42. PMID 6277904  1
1981 Ciechanover A, Heller H, Katz-Etzion R, Hershko A. Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. Proceedings of the National Academy of Sciences of the United States of America. 78: 761-5. PMID 6262770  1
1981 Hershko A, Ciechanover A, Rose IA. Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown. The Journal of Biological Chemistry. 256: 1525-8. PMID 6257674  1
1980 Hershko A, Ciechanover A, Heller H, Haas AL, Rose IA. Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 77: 1783-6. PMID 6990414  1
1980 Ciechanover A, Heller H, Elias S, Haas AL, Hershko A. ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proceedings of the National Academy of Sciences of the United States of America. 77: 1365-8. PMID 6769112  1
1980 Ciechanover A, Elias S, Heller H, Ferber S, Hershko A. Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. The Journal of Biological Chemistry. 255: 7525-8. PMID 6249802  1
1979 Hershko A, Ciechanover A, Rose IA. Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proceedings of the National Academy of Sciences of the United States of America. 76: 3107-10. PMID 290989  1
1976 Ciechanover A, Hershko A. Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts. Biochemical and Biophysical Research Communications. 73: 85-91. PMID 187191 DOI: 10.1016/0006-291X(76)90500-3  1
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