G. Michael Blackburn - Publications

The University of Sheffield 
chemical biology

60 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Wang Q, He Y, Lu R, Wang WM, Yang KW, Fan HM, Jin Y, Blackburn GM. Thermokinetic Profile of NDM-1 and Its Inhibition by Small Carboxylic Acids. Bioscience Reports. PMID 29507059 DOI: 10.1042/BSR20180244  0.72
2017 Jin Y, Molt RW, Pellegrini E, Cliff MJ, Bowler MW, Richards NGJ, Blackburn GM, Waltho JP. Assessing the Influence of Mutation on GTPase Transition States by Using X-ray Crystallography, (19) F NMR, and DFT Approaches. Angewandte Chemie (International Ed. in English). 56: 9732-9735. PMID 28498638 DOI: 10.1002/anie.201703074  0.72
2017 Jin Y, Molt RW, Blackburn GM. Metal Fluorides: Tools for Structural and Computational Analysis of Phosphoryl Transfer Enzymes. Topics in Current Chemistry (Journal). 375: 36. PMID 28299727 DOI: 10.1007/s41061-017-0130-y  0.72
2017 Jin Y, Richards NG, Waltho JP, Blackburn GM. Metal Fluorides as Analogues for Studies on Phosphoryl Transfer Enzymes. Angewandte Chemie (International Ed. in English). 56: 4110-4128. PMID 27862756 DOI: 10.1002/anie.201606474  0.72
2016 Jin Y, Molt RW, Waltho JP, Richards NG, Blackburn GM. (19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA-Catalyzed GTP Hydrolysis. Angewandte Chemie (International Ed. in English). 55: 3318-22. PMID 26822702 DOI: 10.1002/anie.201509477  0.72
2014 Jin Y, Bhattasali D, Pellegrini E, Forget SM, Baxter NJ, Cliff MJ, Bowler MW, Jakeman DL, Blackburn GM, Waltho JP. α-Fluorophosphonates reveal how a phosphomutase conserves transition state conformation over hexose recognition in its two-step reaction. Proceedings of the National Academy of Sciences of the United States of America. 111: 12384-9. PMID 25104750 DOI: 10.1073/pnas.1402850111  0.72
2013 Ilyushin DG, Smirnov IV, Belogurov AA, Dyachenko IA, Zharmukhamedova TIu, Novozhilova TI, Bychikhin EA, Serebryakova MV, Kharybin ON, Murashev AN, Anikienko KA, Nikolaev EN, Ponomarenko NA, Genkin DD, Blackburn GM, et al. Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo. Proceedings of the National Academy of Sciences of the United States of America. 110: 1243-8. PMID 23297221 DOI: 10.1073/pnas.1211118110  0.72
2012 Blackburn GM, Bowler MW, Jin Y, Waltho JP. Reflections on biocatalysis involving phosphorus. Biochemistry. Biokhimii͡A. 77: 1083-96. PMID 23157289 DOI: 10.1134/S000629791210001X  0.72
2012 Jin Y, Cliff MJ, Baxter NJ, Dannatt HR, Hounslow AM, Bowler MW, Blackburn GM, Waltho JP. Charge-balanced metal fluoride complexes for protein kinase A with adenosine diphosphate and substrate peptide SP20. Angewandte Chemie (International Ed. in English). 51: 12242-5. PMID 23125010 DOI: 10.1002/anie.201204266  0.72
2012 Griffin JL, Bowler MW, Baxter NJ, Leigh KN, Dannatt HR, Hounslow AM, Blackburn GM, Webster CE, Cliff MJ, Waltho JP. Near attack conformers dominate β-phosphoglucomutase complexes where geometry and charge distribution reflect those of substrate. Proceedings of the National Academy of Sciences of the United States of America. 109: 6910-5. PMID 22505741 DOI: 10.1073/pnas.1116855109  0.72
2011 Zeng Z, Luo P, Jiang Y, Liu Y, Tang G, Xu P, Zhao Y, Blackburn GM. Chiral phosphoproline-catalyzed asymmetric Michael addition of ketones to nitroolefins: an experimental and theoretical study. Organic & Biomolecular Chemistry. 9: 6973-8. PMID 21863184 DOI: 10.1039/c1ob06143g  0.72
2011 Xiaoxia L, Marston JP, Baxter NJ, Hounslow AM, Yufen Z, Blackburn GM, Cliff MJ, Waltho JP. Prioritization of charge over geometry in transition state analogues of a dual specificity protein kinase. Journal of the American Chemical Society. 133: 3989-94. PMID 21348513 DOI: 10.1021/ja1090035  0.72
2010 Cliff MJ, Bowler MW, Varga A, Marston JP, Szabó J, Hounslow AM, Baxter NJ, Blackburn GM, Vas M, Waltho JP. Transition state analogue structures of human phosphoglycerate kinase establish the importance of charge balance in catalysis. Journal of the American Chemical Society. 132: 6507-16. PMID 20397725 DOI: 10.1021/ja100974t  0.72
2010 Baxter NJ, Bowler MW, Alizadeh T, Cliff MJ, Hounslow AM, Wu B, Berkowitz DB, Williams NH, Blackburn GM, Waltho JP. Atomic details of near-transition state conformers for enzyme phosphoryl transfer revealed by MgF-3 rather than by phosphoranes. Proceedings of the National Academy of Sciences of the United States of America. 107: 4555-60. PMID 20164409 DOI: 10.1073/pnas.0910333106  0.72
2010 Marston JP, Cliff MJ, Reed MA, Blackburn GM, Hounslow AM, Craven CJ, Waltho JP. Structural tightening and interdomain communication in the catalytic cycle of phosphoglycerate kinase. Journal of Molecular Biology. 396: 345-60. PMID 19944703 DOI: 10.1016/j.jmb.2009.11.052  0.72
2010 Bowler MW, Cliff MJ, Waltho JP, Blackburn GM. Why did Nature select phosphate for its dominant roles in biology? New Journal of Chemistry. 34: 784-794. DOI: 10.1039/b9nj00718k  0.72
2009 Baxter NJ, Hounslow AM, Bowler MW, Williams NH, Blackburn GM, Waltho JP. MgF(3)(-) and alpha-galactose 1-phosphate in the active site of beta-phosphoglucomutase form a transition state analogue of phosphoryl transfer. Journal of the American Chemical Society. 131: 16334-5. PMID 19852484 DOI: 10.1021/ja905972m  0.72
2009 Guranowski A, Starzy?ska E, Pietrowska-Borek M, Rejman D, Blackburn GM. Novel diadenosine polyphosphate analogs with oxymethylene bridges replacing oxygen in the polyphosphate chain: potential substrates and/or inhibitors of Ap4A hydrolases. The Febs Journal. 276: 1546-53. PMID 19210543 DOI: 10.1111/j.1742-4658.2009.06882.x  0.72
2009 Hou JB, Zhang H, Guo JN, Liu Y, Xu PX, Zhao YF, Blackburn GM. Chirality at phosphorus in pentacoordinate spirophosphoranes: Stereochemistry by X-ray structure and spectroscopic analysis Organic and Biomolecular Chemistry. 7: 3020-3023. DOI: 10.1039/b909786d  0.72
2008 Guranowski A, Wojdy?a AM, Pietrowska-Borek M, Bieganowski P, Khurs EN, Cliff MJ, Blackburn GM, B?aziak D, Stec WJ. Fhit proteins can also recognize substrates other than dinucleoside polyphosphates. Febs Letters. 582: 3152-8. PMID 18694747 DOI: 10.1016/j.febslet.2008.07.060  0.72
2008 Hounslow AM, Carran J, Brown RJ, Rejman D, Blackburn GM, Watts DJ. Determination of the microscopic equilibrium dissociation constants for risedronate and its analogues reveals two distinct roles for the nitrogen atom in nitrogen-containing bisphosphonate drugs. Journal of Medicinal Chemistry. 51: 4170-8. PMID 18590315 DOI: 10.1021/jm7015792  0.72
2008 Baxter NJ, Blackburn GM, Marston JP, Hounslow AM, Cliff MJ, Bermel W, Williams NH, Hollfelder F, Wemmer DE, Waltho JP. Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes. Journal of the American Chemical Society. 130: 3952-8. PMID 18318536 DOI: 10.1021/ja078000n  0.72
2008 Black DC, Blackburn GM, Johnston GAR. Aldehydic and Ketonic Monocarboxylic Acids and Related Compounds Rodd's Chemistry of Carbon Compounds: a Modern Comprehensive Treatise: Second Edition. 1: 214-274. DOI: 10.1016/B978-044453345-6.50499-5  0.72
2008 Black DC, Blackburn GM, Johnston GAR. Aliphatic Monohydroxy-monocarboxylic Acids and Related Compounds Rodd's Chemistry of Carbon Compounds: a Modern Comprehensive Treatise: Second Edition. 1: 80-141. DOI: 10.1016/B978-044453345-6.50497-1  0.72
2006 Baxter NJ, Olguin LF, Golicnik M, Feng G, Hounslow AM, Bermel W, Blackburn GM, Hollfelder F, Waltho JP, Williams NH. A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site. Proceedings of the National Academy of Sciences of the United States of America. 103: 14732-7. PMID 16990434 DOI: 10.1073/pnas.0604448103  0.72
2006 Russell RJ, Haire LF, Stevens DJ, Collins PJ, Lin YP, Blackburn GM, Hay AJ, Gamblin SJ, Skehel JJ. The structure of H5N1 avian influenza neuraminidase suggests new opportunities for drug design. Nature. 443: 45-9. PMID 16915235 DOI: 10.1038/nature05114  0.72
2006 Couture JF, Hauk G, Thompson MJ, Blackburn GM, Trievel RC. Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases. The Journal of Biological Chemistry. 281: 19280-7. PMID 16682405 DOI: 10.1074/jbc.M602257200  0.72
2005 Spencer J, Read J, Sessions RB, Howell S, Blackburn GM, Gamblin SJ. Antibiotic recognition by binuclear metallo-beta-lactamases revealed by X-ray crystallography. Journal of the American Chemical Society. 127: 14439-44. PMID 16218639 DOI: 10.1021/ja0536062  0.72
2005 Boyle NA, Chegwidden WR, Blackburn GM. A new synthesis of difluoromethanesulfonamides--a novel pharmacophore for carbonic anhydrase inhibition. Organic & Biomolecular Chemistry. 3: 222-4. PMID 15632962 DOI: 10.1039/b416642f  0.72
2004 Berrisford JM, Akerboom J, Brouns S, Sedelnikova SE, Turnbull AP, van der Oost J, Salmon L, Hardré R, Murray IA, Blackburn GM, Rice DW, Baker PJ. The structures of inhibitor complexes of Pyrococcus furiosus phosphoglucose isomerase provide insights into substrate binding and catalysis. Journal of Molecular Biology. 343: 649-57. PMID 15465052 DOI: 10.1016/j.jmb.2004.08.061  0.72
2004 Krakowiak A, Pace HC, Blackburn GM, Adams M, Mekhalfia A, Kaczmarek R, Baraniak J, Stec WJ, Brenner C. Biochemical, crystallographic, and mutagenic characterization of hint, the AMP-lysine hydrolase, with novel substrates and inhibitors. The Journal of Biological Chemistry. 279: 18711-6. PMID 14982931 DOI: 10.1074/jbc.M314271200  0.72
2003 Spelta V, Mekhalfia A, Rejman D, Thompson M, Blackburn GM, North RA. ATP analogues with modified phosphate chains and their selectivity for rat P2X2 and P2X2/3 receptors. British Journal of Pharmacology. 140: 1027-34. PMID 14581175 DOI: 10.1038/sj.bjp.0705531  0.72
2003 Blackburn GM, Williams NH, Gamblin SJ, Smerdon SJ. Comment on "The pentacovalent phosphorus intermediate of a phosphoryl transfer reaction". Science (New York, N.Y.). 301: 1184; author reply 1. PMID 12947182 DOI: 10.1126/science.1085796  0.72
2003 Cesaro-Tadic S, Lagos D, Honegger A, Rickard JH, Partridge LJ, Blackburn GM, Plückthun A. Turnover-based in vitro selection and evolution of biocatalysts from a fully synthetic antibody library. Nature Biotechnology. 21: 679-85. PMID 12754520 DOI: 10.1038/nbt828  0.72
2003 Hinckley GT, Ruzicka FJ, Thompson MJ, Blackburn GM, Frey PA. Adenosyl coenzyme and pH dependence of the [4Fe-4S]2+/1+ transition in lysine 2,3-aminomutase. Archives of Biochemistry and Biophysics. 414: 34-9. PMID 12745252 DOI: 10.1016/S0003-9861(03)00160-7  0.72
2003 Jakeman DL, Ivory AJ, Blackburn GM, Williamson MP. Orientation of 1,3-bisphosphoglycerate analogs bound to phosphoglycerate kinase. The Journal of Biological Chemistry. 278: 10957-62. PMID 12509431 DOI: 10.1074/jbc.M211769200  0.36
2002 Betley JR, Cesaro-Tadic S, Mekhalfia A, Rickard JH, Denham H, Partridge LJ, Plückthun A, Blackburn GM. Direct screening for phosphatase activity by turnover-based capture of protein catalysts. Angewandte Chemie (International Ed. in English). 41: 775-7. PMID 12491332 DOI: 10.1002/1521-3773(20020301)41:5<775::AID-ANIE775>3.0.CO;2-F  0.72
2002 Wilson JR, Jing C, Walker PA, Martin SR, Howell SA, Blackburn GM, Gamblin SJ, Xiao B. Crystal structure and functional analysis of the histone methyltransferase SET7/9. Cell. 111: 105-15. PMID 12372304 DOI: 10.1016/S0092-8674(02)00964-9  0.72
2001 Dinner AR, Blackburn GM, Karplus M. Uracil-DNA glycosylase acts by substrate autocatalysis. Nature. 413: 752-5. PMID 11607036 DOI: 10.1038/35099587  0.72
2001 Ruzheinikov SN, Das SK, Sedelnikova SE, Hartley A, Foster SJ, Horsburgh MJ, Cox AG, McCleod CW, Mekhalfia A, Blackburn GM, Rice DW, Baker PJ. The 1.2 A structure of a novel quorum-sensing protein, Bacillus subtilis LuxS. Journal of Molecular Biology. 313: 111-22. PMID 11601850 DOI: 10.1006/jmbi.2001.5027  0.72
2000 Rösler A, Panayotou G, Hornby DP, Barlow T, Brown T, Pearl LH, Savva R, Blackburn GM. The mechanism of DNA repair by uracil-DNA glycosylase: studies using nucleotide analogues. Nucleosides, Nucleotides & Nucleic Acids. 19: 1505-16. PMID 11200255 DOI: 10.1080/15257770008045442  0.72
2000 Parikh SS, Walcher G, Jones GD, Slupphaug G, Krokan HE, Blackburn GM, Tainer JA. Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects. Proceedings of the National Academy of Sciences of the United States of America. 97: 5083-8. PMID 10805771 DOI: 10.1073/pnas.97.10.5083  0.72
1998 Williams DM, Jakeman DL, Vyle JS, Williamson MP, Blackburn GM. Synthesis and binding of stable bisubstrate ligands for phosphoglycerate kinase. Bioorganic & Medicinal Chemistry Letters. 8: 2603-8. PMID 9873589  0.36
1998 Caplan NA, Pogson CI, Hayes DJ, Blackburn GM. Novel bisphosphonate inhibitors of phosphoglycerate kinase. Bioorganic & Medicinal Chemistry Letters. 8: 515-20. PMID 9871609 DOI: 10.1016/S0960-894X(98)00059-6  0.72
1998 Jakeman DL, Ivory AJ, Williamson MP, Blackburn GM. Highly potent bisphosphonate ligands for phosphoglycerate kinase. Journal of Medicinal Chemistry. 41: 4439-52. PMID 9804684 DOI: 10.1021/jm970839y  0.36
1998 Blackburn GM, Liu X, Rösler A, Brenner C. Two hydrolase resistant analogues of diadenosine 5',5"'-P1,P3-triphosphate for studies with Fhit, the human fragile histidine triad protein. Nucleosides & Nucleotides. 17: 301-8. PMID 9708352  0.72
1998 Pace HC, Garrison PN, Robinson AK, Barnes LD, Draganescu A, Rösler A, Blackburn GM, Siprashvili Z, Croce CM, Huebner K, Brenner C. Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit. Proceedings of the National Academy of Sciences of the United States of America. 95: 5484-9. PMID 9576908 DOI: 10.1073/pnas.95.10.5484  0.72
1997 Brenner C, Pace HC, Garrison PN, Robinson AK, Rosler A, Liu XH, Blackburn GM, Croce CM, Huebner K, Barnes LD. Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein. Protein Engineering. 10: 1461-3. PMID 9543008  0.72
1997 Delaney SM, Blackburn GM, Geiger JD. Diadenosine polyphosphates inhibit adenosine kinase activity but decrease levels of endogenous adenosine in rat brain. European Journal of Pharmacology. 332: 35-42. PMID 9298923 DOI: 10.1016/S0014-2999(97)01057-1  0.72
1997 Chan SW, Gallo SJ, Kim BK, Guo MJ, Blackburn GM, Zamecnik PC. P1,P4-dithio-P2,P3-monochloromethylene diadenosine 5',5'''-P1,P4-tetraphosphate: a novel antiplatelet agent. Proceedings of the National Academy of Sciences of the United States of America. 94: 4034-9. PMID 9108100 DOI: 10.1073/pnas.94.8.4034  0.72
1996 Craven CJ, Whitehead B, Jones SK, Thulin E, Blackburn GM, Waltho JP. Complexes formed between calmodulin and the antagonists J-8 and TFP in solution. Biochemistry. 35: 10287-99. PMID 8756684 DOI: 10.1021/bi9605043  0.72
1996 Wentworth P, Datta A, Blakey D, Boyle T, Partridge LJ, Blackburn GM. Toward antibody-directed "abzyme" prodrug therapy, ADAPT: carbamate prodrug activation by a catalytic antibody and its in vitro application to human tumor cell killing. Proceedings of the National Academy of Sciences of the United States of America. 93: 799-803. PMID 8570638 DOI: 10.1073/pnas.93.2.799  0.72
1995 Parsons ID, Persson B, Mekhalfia A, Blackburn GM, Stockley PG. Probing the molecular mechanism of action of co-repressor in the E. coli methionine repressor-operator complex using surface plasmon resonance (SPR). Nucleic Acids Research. 23: 211-6. PMID 7862523 DOI: 10.1093/nar/23.2.211  0.72
1992 Zamecnik PC, Kim B, Gao MJ, Taylor G, Blackburn GM. Analogues of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) as potential anti-platelet-aggregation agents. Proceedings of the National Academy of Sciences of the United States of America. 89: 2370-3. PMID 1549600  0.72
1992 Dalton A, Hornby DP, Langston SP, Blackburn GM. Characterization and purification of a novel dATP-binding protein in eukaryotes. The Biochemical Journal. 287: 871-9. PMID 1445246  0.72
1992 Rogers MJ, Russell RG, Blackburn GM, Williamson MP, Watts DJ. Metabolism of halogenated bisphosphonates by the cellular slime mould Dictyostelium discoideum. Biochemical and Biophysical Research Communications. 189: 414-23. PMID 1333194 DOI: 10.1016/0006-291X(92)91574-A  0.72
1988 MacNeil S, Griffin M, Cooke AM, Pettett NJ, Dawson RA, Owen R, Blackburn GM. Calmodulin antagonists of improved potency and specificity for use in the study of calmodulin biochemistry. Biochemical Pharmacology. 37: 1717-23. PMID 2897857 DOI: 10.1016/0006-2952(88)90434-0  0.72
1987 Blackburn GM, Taylor GE, Thatcher GR, Prescott M, McLennan AG. Synthesis and resistance to enzymic hydrolysis of stereochemically-defined phosphonate and thiophosphate analogues of P1,P4-bis(5'-adenosyl) tetraphosphate. Nucleic Acids Research. 15: 6991-7004. PMID 2821489  0.72
1985 Blackburn GM, Mann BE, Taylor BF, Worrall AF. A nuclear-magnetic-resonance study of the binding of novel N-hydroxybenzenesulphonamide carbonic anhydrase inhibitors to native and cadmium-111-substituted carbonic anhydrase. European Journal of Biochemistry / Febs. 153: 553-8. PMID 3935439  0.48
1969 Blackburn GM, Brown MJ, Harris MR, Shire D. Synthetic studies of nucleic acids on polymer supports. II. Mechanisms of phosphorylation with carbodi-imides and arenesulphonyl chlorides. Journal of the Chemical Society. Perkin Transactions 1. 4: 676-83. PMID 5813421  0.72
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