Eric Oldfield - Publications

Affiliations: 
Chemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
biomolecular NMR
Website:
http://www.chemistry.illinois.edu/faculty/Eric_Oldfield.html

255 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Han S, Li X, Xia Y, Yu Z, Cai N, Malwal SR, Han X, Oldfield E, Zhang Y. Farnesyl Pyrophosphate Synthase as a Target for Drug Development: Discovery of Natural Product-Derived Inhibitors and Their Activity in Pancreatic Cancer Cells. Journal of Medicinal Chemistry. PMID 31725297 DOI: 10.1021/acs.jmedchem.9b01405  0.88
2019 Buter J, Cheng TY, Ghanem M, Grootemaat AE, Raman S, Feng X, Plantijn AR, Ennis T, Wang J, Cotton RN, Layre E, Ramnarine AK, Mayfield JA, Young DC, Jezek Martinot A, ... ... Oldfield E, et al. Mycobacterium tuberculosis releases an antacid that remodels phagosomes. Nature Chemical Biology. 15: 889-899. PMID 31427817 DOI: 10.1038/s41589-019-0336-0  1
2019 Song J, Shang N, Baig N, Yao J, Shin C, Kim BK, Li Q, Malwal SR, Oldfield E, Feng X, Guo RT. Aspergillus flavus squalene synthase as an antifungal target: Expression, activity, and inhibition. Biochemical and Biophysical Research Communications. PMID 30904161 DOI: 10.1016/j.bbrc.2019.03.070  1
2019 Yang Y, Li L, Yuan L, Zhou X, Duan J, Xiao H, Cai N, Han S, Ma X, Liu W, Chen CC, Wang L, Li X, Chen J, Kang N, ... ... Oldfield E, et al. A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated Vγ9Vδ2 T Cell Activation. Immunity. PMID 30902636 DOI: 10.1016/j.immuni.2019.02.016  0.88
2019 Zhang L, Ko TP, Malwal SR, Liu W, Zhou S, Yu X, Oldfield E, Guo RT, Chen CC. Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism. Biochemical and Biophysical Research Communications. PMID 30837154 DOI: 10.1016/j.bbrc.2019.02.131  0.8
2019 Malwal S, Chen L, Hicks H, Qu F, Liu W, Shillo A, Law WX, Zhang J, Chandnani N, Han X, Zheng Y, Chen CC, Guo RT, AbdelKhalek A, Seleem MN, ... Oldfield E, et al. Discovery of Lipophilic Bisphosphonates that Target Bacterial Cell Wall and Quinone Biosynthesis. Journal of Medicinal Chemistry. PMID 30730737 DOI: 10.1021/acs.jmedchem.8b01878  0.8
2018 Malwal SR, Gao J, Hu X, Yang Y, Liu W, Huang JW, Ko TP, Li L, Chen CC, O'Dowd B, Khade RL, Zhang Y, Zhang Y, Oldfield E, Guo RT. Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. Acs Catalysis. 8: 4299-4312. PMID 30345154 DOI: 10.1021/acscatal.8b00543  0.88
2018 Xia Y, Xie Y, Yu Z, Xiao H, Jiang G, Zhou X, Yang Y, Li X, Zhao M, Li L, Zheng M, Han S, Zong Z, Meng X, Deng H, ... ... Oldfield E, et al. The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery. Cell. PMID 30270039 DOI: 10.1016/j.cell.2018.08.070  0.88
2018 Kang L, Gao XH, Liu HR, Men X, Wu HN, Cui PW, Oldfield E, Yan JY. Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors. Molecular Diversity. PMID 29934672 DOI: 10.1007/s11030-018-9839-y  0.8
2018 Malwal SR, O'Dowd B, Feng X, Turhanen PA, Shin CJ, Yao J, Kim BK, Baig N, Zhou T, Bansal S, Khade RL, Zhang Y, Oldfield E. Bisphosphonate-Generated ATP-Analogs Inhibit Cell Signaling Pathways. Journal of the American Chemical Society. PMID 29787268 DOI: 10.1021/jacs.8b02363  1
2018 Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS. Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA). European Journal of Medicinal Chemistry. 148: 195-209. PMID 29459278 DOI: 10.1016/j.ejmech.2018.02.031  0.64
2018 Venkatramani A, G Ricci C, Oldfield E, Andrew McCammon J. Remarkable Similarity in Plasmodium falciparum and Plasmodium vivax Geranylgeranyl Diphosphate Synthase (GGPPS) Dynamics and its Implication for Anti-Malarial Drug Design. Chemical Biology & Drug Design. PMID 29345110 DOI: 10.1111/cbdd.13170  0.52
2017 Gao J, Ko TP, Chen L, Malwal SR, Zhang J, Hu X, Qu F, Liu W, Huang JW, Cheng YS, Chen CC, Yang Y, Zhang Y, Oldfield E, Guo RT. New views of head-to-middle and cis- head-to-tail prenyltransferases: Structure of isosesquilavandulyl diphosphate synthase. Angewandte Chemie (International Ed. in English). PMID 29215779 DOI: 10.1002/anie.201710185  0.88
2017 Zhou X, Gu Y, Xiao H, Kang N, Xie Y, Zhang G, Shi Y, Hu X, Oldfield E, Zhang X, Zhang Y. Combining Vγ9Vδ2 T Cells with a Lipophilic Bisphosphonate Efficiently Kills Activated Hepatic Stellate Cells. Frontiers in Immunology. 8: 1381. PMID 29118758 DOI: 10.3389/fimmu.2017.01381  0.88
2017 Rao G, Bansal S, Law WX, O'Dowd B, Dikanov SA, Oldfield E. Pulsed EPR insights into the ligand environment of copper in Drosophila lysyl oxidase. Biochemistry. PMID 28660757 DOI: 10.1021/acs.biochem.7b00308  1
2017 Boulmier A, Feng X, Oms O, Mialane P, Rivière E, Shin CJ, Yao J, Kubo T, Furuta T, Oldfield E, Dolbecq A. Anticancer Activity of Polyoxometalate-Bisphosphonate Complexes: Synthesis, Characterization, In Vitro and In Vivo Results. Inorganic Chemistry. PMID 28631925 DOI: 10.1021/acs.inorgchem.7b01114  1
2017 Schwalen CJ, Feng X, Liu W, O-Dowd B, Ko TP, Shin CJ, Guo RT, Mitchell DA, Oldfield E. "Head-to-head" Prenyl Synthases in Some Pathogenic Bacteria. Chembiochem : a European Journal of Chemical Biology. PMID 28340291 DOI: 10.1002/cbic.201700099  1
2017 O'Dowd B, Williams S, Wang H, No JH, Rao G, Wang W, McCammon JA, Cramer SP, Oldfield E. Spectroscopic and Computational Investigations of Ligand Binding to IspH: Discovery of Non-Diphosphate Inhibitors. Chembiochem : a European Journal of Chemical Biology. PMID 28253432 DOI: 10.1002/cbic.201700052  1
2017 Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper BR, Zhang J, Mayhoub AS, Oldfield E, Cushman MS, Seleem MN. Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity In Vitro and In Vivo against Vancomycin-resistant Enterococci. Journal of Medicinal Chemistry. PMID 28248504 DOI: 10.1021/acs.jmedchem.6b01780  0.48
2016 Wang Y, Desai J, Zhang Y, Malwal SR, Shin CJ, Feng X, Sun H, Liu G, Guo RT, Oldfield E. Bacterial Cell Growth Inhibitors Targeting Undecaprenyl Diphosphate Synthase and Undecaprenyl Diphosphate Phosphatase. Chemmedchem. PMID 27578312 DOI: 10.1002/cmdc.201600342  1
2016 Desai J, Wang Y, Wang K, Malwal SR, Oldfield E. Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth. Chemmedchem. PMID 27571880 DOI: 10.1002/cmdc.201600343  1
2016 G Ricci C, Liu YL, Zhang Y, Wang Y, Zhu W, Oldfield E, McCammon JA. Dynamic Structure and Inhibition of a Malaria Drug Target: Geranylgeranyl Diphosphate Synthase. Biochemistry. 55: 5180-90. PMID 27564465 DOI: 10.1021/acs.biochem.6b00398  0.92
2016 Bai Y, Feng X, Xing H, Xu Y, Kim BK, Baig N, Zhou T, Gewirth AA, Lu Y, Oldfield E, Zimmerman SC. A Highly Efficient Single-Chain Metal-Organic Nanoparticle Catalyst for Alkyne-Azide "Click" Reactions in Water and in Cells. Journal of the American Chemical Society. PMID 27529791 DOI: 10.1021/jacs.6b04477  1
2016 Desai J, Liu YL, Wei H, Liu W, Ko TP, Guo RT, Oldfield E. Structure, Function, and Inhibition of Staphylococcus aureus Heptaprenyl Diphosphate Synthase. Chemmedchem. PMID 27457559 DOI: 10.1002/cmdc.201600311  1
2016 Rao G, Oldfield E. Structure and Function of Four Classes of the 4Fe-4S Protein, IspH. Biochemistry. PMID 27357244 DOI: 10.1021/acs.biochem.6b00474  1
2016 Zhang L, Chen CC, Ko TP, Huang JW, Zheng Y, Liu W, Wang I, Malwal SR, Feng X, Wang K, Huang CH, Hsu SD, Wang AH, Oldfield E, Guo RT. Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5. Angewandte Chemie (International Ed. in English). PMID 26954060 DOI: 10.1002/anie.201511388  1
2016 Liu M, Chen CC, Chen L, Xiao X, Zheng Y, Huang JW, Liu W, Ko TP, Cheng YS, Feng X, Oldfield E, Guo RT, Ma Y. Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase. Angewandte Chemie (International Ed. in English). PMID 26922900 DOI: 10.1002/anie.201600656  1
2016 Yang Y, Ko TP, Chen CC, Huang G, Zheng Y, Liu W, Wang I, Ho MR, Hsu SD, O'Dowd B, Huff HC, Huang CH, Docampo R, Oldfield E, Guo RT. Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Anti-Parasitic Drug Targets. Acs Chemical Biology. PMID 26907161 DOI: 10.1021/acschembio.5b00724  1
2015 Rao G, O'Dowd B, Li J, Wang K, Oldfield E. IspH-RPS1 and IspH-UbiA: "Rosetta Stone" Proteins. Chemical Science (Royal Society of Chemistry : 2010). 6: 6813-6822. PMID 26865948 DOI: 10.1039/C5SC02600H  1
2015 Hu Y, Liu W, Malwal SR, Zheng Y, Feng X, Ko TP, Chen CC, Xu Z, Liu M, Han X, Gao J, Oldfield E, Guo RT. Structures of Iridoid Synthase from Cantharanthus roseus with Bound NAD(+) , NADPH, or NAD(+) /10-Oxogeranial: Reaction Mechanisms. Angewandte Chemie (International Ed. in English). 54: 15478-82. PMID 26768532 DOI: 10.1002/anie.201508310  1
2015 Feng X, Zhu W, Schurig-Briccio LA, Lindert S, Shoen C, Hitchings R, Li J, Wang Y, Baig N, Zhou T, Kim BK, Crick DC, Cynamon M, McCammon JA, Gennis RB, ... Oldfield E, et al. Antiinfectives targeting enzymes and the proton motive force. Proceedings of the National Academy of Sciences of the United States of America. 112: E7073-82. PMID 26644565 DOI: 10.1073/pnas.1521988112  1
2015 Li J, Feng X, Zhu W, Oskolkov N, Zhou T, Kim BK, Baig N, McMahon MT, Oldfield E. Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26616530 DOI: 10.1002/chem.201503942  1
2015 Huntoon K, Wu T, Elder JB, Butman JA, Chew EY, Linehan WM, Oldfield EH, Lonser RR. Biological and clinical impact of hemangioblastoma-associated peritumoral cysts in von Hippel-Lindau disease. Journal of Neurosurgery. 1-6. PMID 26517769 DOI: 10.3171/2015.4.JNS1533  0.48
2015 Yang G, Zhu W, Kim K, Byun SY, Choi G, Wang K, Cha JS, Cho HS, Oldfield E, No JH. Inhibition of Trypanosoma brucei Cell Growth by Lipophilic Bisphosphonates: An In Vitro and In Vivo Investigation. Antimicrobial Agents and Chemotherapy. PMID 26392508 DOI: 10.1128/AAC.01873-15  1
2015 Parekh PJ, Oldfield EC, Johnson DA. Current Strategies to Reduce Gastrointestinal Bleeding Risk Associated with Antiplatelet Agents. Drugs. 75: 1613-25. PMID 26330139 DOI: 10.1007/s40265-015-0455-1  0.88
2015 Yang G, Zhu W, Wang Y, Huang G, Byun S, Choi G, Li K, Huang Z, Docampo R, Oldfield E, No JH. In Vitro and In Vivo Activity of Multi-Target Inhibitors Against Trypanosoma brucei. Acs Infectious Diseases. 1: 388-398. PMID 26295062 DOI: 10.1021/acsinfecdis.5b00068  1
2015 Farha MA, Czarny TL, Myers CL, Worrall LJ, French S, Conrady DG, Wang Y, Oldfield E, Strynadka NC, Brown ED. Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase. Proceedings of the National Academy of Sciences of the United States of America. 112: 11048-53. PMID 26283394 DOI: 10.1073/pnas.1511751112  1
2015 Li K, Wang Y, Yang G, Byun S, Rao G, Shoen C, Yang H, Gulati A, Crick DC, Cynamon M, Huang G, Docampo R, No JH, Oldfield E. Oxa, Thia, Heterocycle, and Carborane Analogues of SQ109: Bacterial and Protozoal Cell Growth Inhibitors. Acs Infectious Diseases. 1: 215-221. PMID 26258172 DOI: 10.1021/acsinfecdis.5b00026  1
2015 Oldfield EH, Vance ML, Louis RG, Pledger CL, Jane JA, Lopes MB. Crooke's Changes In Cushing's Syndrome Depends on Degree of Hypercortisolism and Individual Susceptibility. The Journal of Clinical Endocrinology and Metabolism. 100: 3165-71. PMID 26147609 DOI: 10.1210/JC.2015-2493  0.6
2015 Saad A, Zhu W, Rousseau G, Mialane P, Marrot J, Haouas M, Taulelle F, Dessapt R, Serier-Brault H, Rivière E, Kubo T, Oldfield E, Dolbecq A. Polyoxomolybdate Bisphosphonate Heterometallic Complexes: Synthesis, Structure, and Activity on a Breast Cancer Cell Line. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26076183 DOI: 10.1002/chem.201406565  1
2015 Oldfield E. Tuberculosis terpene targets. Chemistry & Biology. 22: 437-8. PMID 25910241 DOI: 10.1016/j.chembiol.2015.04.004  1
2015 Quitterer F, Frank A, Wang K, Rao G, O'Dowd B, Li J, Guerra F, Abdel-Azeim S, Bacher A, Eppinger J, Oldfield E, Groll M. Atomic-Resolution Structures of Discrete Stages on the Reaction Coordinate of the [Fe4S4] Enzyme IspG (GcpE). Journal of Molecular Biology. 427: 2220-8. PMID 25868383 DOI: 10.1016/j.jmb.2015.04.002  1
2015 Oldfield EH, Merrill MJ. Apoplexy of pituitary adenomas: the perfect storm. Journal of Neurosurgery. 122: 1444-9. PMID 25859802 DOI: 10.3171/2014.10.JNS141720  0.6
2015 Mehta GU, Montgomery BK, Raghavan P, Sharma S, Nieman LK, Patronas N, Oldfield EH, Chittiboina P. Different imaging characteristics of concurrent pituitary adenomas in a patient with Cushing's disease. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia. 22: 891-4. PMID 25827866 DOI: 10.1016/j.jocn.2015.01.001  0.6
2015 Liu YL, Cao R, Wang Y, Oldfield E. Farnesyl diphosphate synthase inhibitors with unique ligand-binding geometries. Acs Medicinal Chemistry Letters. 6: 349-54. PMID 25815158 DOI: 10.1021/ml500528x  1
2015 Xia Y, Yeddula N, Leblanc M, Ke E, Zhang Y, Oldfield E, Shaw RJ, Verma IM. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nature Cell Biology. 17: 532. PMID 25812528 DOI: 10.1038/ncb3145  0.88
2015 Huntoon K, Oldfield EH, Lonser RR. Dr. Arvid Lindau and discovery of von Hippel-Lindau disease. Journal of Neurosurgery. 1-5. PMID 25748307 DOI: 10.3171/2015.1.JNS131963  0.44
2015 Veiga-Santos P, Li K, Lameira L, de Carvalho TM, Huang G, Galizzi M, Shang N, Li Q, Gonzalez-Pacanowska D, Hernandez-Rodriguez V, Benaim G, Guo RT, Urbina JA, Docampo R, de Souza W, ... Oldfield E, et al. SQ109, a new drug lead for Chagas disease. Antimicrobial Agents and Chemotherapy. 59: 1950-61. PMID 25583723 DOI: 10.1128/AAC.03972-14  1
2015 Zhu W, Wang Y, Li K, Gao J, Huang CH, Chen CC, Ko TP, Zhang Y, Guo RT, Oldfield E. Antibacterial drug leads: DNA and enzyme multitargeting. Journal of Medicinal Chemistry. 58: 1215-27. PMID 25574764 DOI: 10.1021/jm501449u  1
2015 Faucz FR, Horvath AD, Azevedo MF, Levy I, Bak B, Wang Y, Xekouki P, Szarek E, Gourgari E, Manning AD, de Alexandre RB, Saloustros E, Trivellin G, Lodish M, Hofman P, ... ... Oldfield E, et al. Is IGSF1 involved in human pituitary tumor formation? Endocrine-Related Cancer. 22: 47-54. PMID 25527509 DOI: 10.1530/ERC-14-0465  0.92
2015 Lonser RR, Sarntinoranont M, Morrison PF, Oldfield EH. Convection-enhanced delivery to the central nervous system. Journal of Neurosurgery. 122: 697-706. PMID 25397365 DOI: 10.3171/2014.10.JNS14229  0.6
2015 Kim MO, Feng X, Feixas F, Zhu W, Lindert S, Bogue S, Sinko W, de Oliveira C, Rao G, Oldfield E, McCammon JA. A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery. Chemical Biology & Drug Design. 85: 756-69. PMID 25352216 DOI: 10.1111/cbdd.12463  1
2015 Han X, Chen CC, Kuo CJ, Huang CH, Zheng Y, Ko TP, Zhu Z, Feng X, Wang K, Oldfield E, Wang AH, Liang PH, Guo RT, Ma Y. Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms. Proteins. 83: 37-45. PMID 24895191 DOI: 10.1002/prot.24618  1
2014 Oldfield E, Feng X. Resistance-resistant antibiotics. Trends in Pharmacological Sciences. 35: 664-74. PMID 25458541 DOI: 10.1016/j.tips.2014.10.007  1
2014 Xia Y, Liu YL, Xie Y, Zhu W, Guerra F, Shen S, Yeddula N, Fischer W, Low W, Zhou X, Zhang Y, Oldfield E, Verma IM. A combination therapy for KRAS-driven lung adenocarcinomas using lipophilic bisphosphonates and rapamycin. Science Translational Medicine. 6: 263ra161. PMID 25411474 DOI: 10.1126/scitranslmed.3010382  1
2014 Feng X, Hu Y, Zheng Y, Zhu W, Li K, Huang CH, Ko TP, Ren F, Chan HC, Nega M, Bogue S, López D, Kolter R, Götz F, Guo RT, ... Oldfield E, et al. Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production. Chemistry & Biology. 21: 1557-63. PMID 25308276 DOI: 10.1016/j.chembiol.2014.08.018  1
2014 Liu W, Feng X, Zheng Y, Huang CH, Nakano C, Hoshino T, Bogue S, Ko TP, Chen CC, Cui Y, Li J, Wang I, Hsu ST, Oldfield E, Guo RT. Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum. Scientific Reports. 4: 6214. PMID 25269599 DOI: 10.1038/srep06214  1
2014 Heiss JD, Oldfield EH. Response. Journal of Neurosurgery. Spine. 21: 315-6. PMID 25221803 DOI: 10.3171/2012.11.SPINE121038  0.6
2014 Parekh PJ, Shams R, Oldfield EC, Nicholas JJ, Johnson DA. Computed tomography colonography: ready for prime time for colon cancer screening? Journal of Clinical Gastroenterology. 48: 745-51. PMID 25144899 DOI: 10.1097/MCG.0000000000000188  0.88
2014 Guerra F, Wang K, Li J, Wang W, Liu YL, Amin S, Oldfield E. Inhibition of the 4Fe-4S Proteins IspG and IspH: an EPR, ENDOR and HYSCORE Investigation. Chemical Science (Royal Society of Chemistry : 2010). 5: 1642-1649. PMID 24999381 DOI: 10.1039/C3SC53301H  1
2014 Dallapiazza R, Bond AE, Grober Y, Louis RG, Payne SC, Oldfield EH, Jane JA. Retrospective analysis of a concurrent series of microscopic versus endoscopic transsphenoidal surgeries for Knosp Grades 0-2 nonfunctioning pituitary macroadenomas at a single institution. Journal of Neurosurgery. 121: 511-7. PMID 24995783 DOI: 10.3171/2014.6.JNS131321  0.6
2014 Liu YL, Lindert S, Zhu W, Wang K, McCammon JA, Oldfield E. Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. Proceedings of the National Academy of Sciences of the United States of America. 111: E2530-9. PMID 24927548 DOI: 10.1073/pnas.1409061111  0.92
2014 Khade RL, Fan W, Ling Y, Yang L, Oldfield E, Zhang Y. Iron porphyrin carbenes as catalytic intermediates: structures, Mössbauer and NMR spectroscopic properties, and bonding. Angewandte Chemie (International Ed. in English). 53: 7574-8. PMID 24910004 DOI: 10.1002/anie.201402472  1
2014 Mehta GU, Bakhtian KD, Oldfield EH. Effect of primary empty sella syndrome on pituitary surgery for Cushing's disease. Journal of Neurosurgery. 121: 518-26. PMID 24857241 DOI: 10.3171/2014.3.JNS132012  0.6
2014 Sinko W, Wang Y, Zhu W, Zhang Y, Feixas F, Cox CL, Mitchell DA, Oldfield E, McCammon JA. Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads. Journal of Medicinal Chemistry. 57: 5693-701. PMID 24827744 DOI: 10.1021/jm5004649  0.92
2014 Span I, Wang K, Eisenreich W, Bacher A, Zhang Y, Oldfield E, Groll M. Insights into the binding of pyridines to the iron-sulfur enzyme IspH. Journal of the American Chemical Society. 136: 7926-32. PMID 24813236 DOI: 10.1021/ja501127j  1
2014 Shang N, Li Q, Ko TP, Chan HC, Li J, Zheng Y, Huang CH, Ren F, Chen CC, Zhu Z, Galizzi M, Li ZH, Rodrigues-Poveda CA, Gonzalez-Pacanowska D, Veiga-Santos P, ... ... Oldfield E, et al. Squalene synthase as a target for Chagas disease therapeutics. Plos Pathogens. 10: e1004114. PMID 24789335 DOI: 10.1371/journal.ppat.1004114  1
2014 Parekh PJ, Oldfield EC, Johnson DA. Treatment of gastroesophageal reflux disease: two new oral formulations dexlansoprazole MR and esomezol (esomeprazole strontium). Expert Opinion On Pharmacotherapy. 15: 1215-22. PMID 24749891 DOI: 10.1517/14656566.2014.911841  0.88
2014 Aripirala S, Gonzalez-Pacanowska D, Oldfield E, Kaiser M, Amzel LM, Gabelli SB. Structural and thermodynamic basis of the inhibition of Leishmania major farnesyl diphosphate synthase by nitrogen-containing bisphosphonates. Acta Crystallographica. Section D, Biological Crystallography. 70: 802-10. PMID 24598749 DOI: 10.1107/S1399004713033221  1
2014 Lonser RR, Butman JA, Huntoon K, Asthagiri AR, Wu T, Bakhtian KD, Chew EY, Zhuang Z, Linehan WM, Oldfield EH. Prospective natural history study of central nervous system hemangioblastomas in von Hippel-Lindau disease. Journal of Neurosurgery. 120: 1055-62. PMID 24579662 DOI: 10.3171/2014.1.JNS131431  0.6
2014 Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, ... ... Oldfield E, et al. Multitarget drug discovery for tuberculosis and other infectious diseases. Journal of Medicinal Chemistry. 57: 3126-39. PMID 24568559 DOI: 10.1021/jm500131s  1
2014 Benaim G, Casanova P, Hernandez-Rodriguez V, Mujica-Gonzalez S, Parra-Gimenez N, Plaza-Rojas L, Concepcion JL, Liu YL, Oldfield E, Paniz-Mondolfi A, Suarez AI. Dronedarone, an amiodarone analog with improved anti-Leishmania mexicana efficacy. Antimicrobial Agents and Chemotherapy. 58: 2295-303. PMID 24492373 DOI: 10.1128/AAC.01240-13  1
2014 Wang W, Oldfield E. Bioorganometallic chemistry with IspG and IspH: structure, function, and inhibition of the [Fe(4)S(4)] proteins involved in isoprenoid biosynthesis. Angewandte Chemie (International Ed. in English). 53: 4294-310. PMID 24481599 DOI: 10.1002/anie.201306712  1
2014 Chan HC, Feng X, Ko TP, Huang CH, Hu Y, Zheng Y, Bogue S, Nakano C, Hoshino T, Zhang L, Lv P, Liu W, Crick DC, Liang PH, Wang AH, ... Oldfield E, et al. Structure and inhibition of tuberculosinol synthase and decaprenyl diphosphate synthase from Mycobacterium tuberculosis. Journal of the American Chemical Society. 136: 2892-6. PMID 24475925 DOI: 10.1021/ja413127v  1
2014 Gläsker S, Smith J, Raffeld M, Li J, Oldfield EH, Vortmeyer AO. VHL-deficient vasculogenesis in hemangioblastoma. Experimental and Molecular Pathology. 96: 162-7. PMID 24394472 DOI: 10.1016/j.yexmp.2013.12.011  0.88
2013 Ziniel PD, Desai J, Cass CL, Gatto C, Oldfield E, Williams DL. Characterization of potential drug targets farnesyl diphosphate synthase and geranylgeranyl diphosphate synthase in Schistosoma mansoni. Antimicrobial Agents and Chemotherapy. 57: 5969-76. PMID 24041901 DOI: 10.1128/AAC.00699-13  1
2013 Oldfield EH, Loomba JJ, Monteith SJ, Crowley RW, Medel R, Gress DR, Kassell NF, Dumont AS, Sherman C. Safety and pharmacokinetics of sodium nitrite in patients with subarachnoid hemorrhage: a phase IIa study. Journal of Neurosurgery. 119: 634-41. PMID 23706046 DOI: 10.3171/2013.3.JNS13266  0.6
2013 Li J, Wang K, Smirnova TI, Khade RL, Zhang Y, Oldfield E. Isoprenoid biosynthesis: ferraoxetane or allyl anion mechanism for IspH catalysis? Angewandte Chemie (International Ed. in English). 52: 6522-5. PMID 23649534 DOI: 10.1002/anie.201302343  1
2013 Wind JJ, Lonser RR, Nieman LK, DeVroom HL, Chang R, Oldfield EH. The lateralization accuracy of inferior petrosal sinus sampling in 501 patients with Cushing's disease. The Journal of Clinical Endocrinology and Metabolism. 98: 2285-93. PMID 23553862 DOI: 10.1210/jc.2012-3943  0.44
2013 Lindert S, Zhu W, Liu YL, Pang R, Oldfield E, McCammon JA. Farnesyl diphosphate synthase inhibitors from in silico screening. Chemical Biology & Drug Design. 81: 742-8. PMID 23421555 DOI: 10.1111/cbdd.12121  0.92
2013 Vortmeyer AO, Falke EA, Gläsker S, Li J, Oldfield EH. Nervous system involvement in von Hippel-Lindau disease: pathology and mechanisms. Acta Neuropathologica. 125: 333-50. PMID 23400300 DOI: 10.1007/s00401-013-1091-z  0.6
2013 Lonser RR, Wind JJ, Nieman LK, Weil RJ, DeVroom HL, Oldfield EH. Outcome of surgical treatment of 200 children with Cushing's disease. The Journal of Clinical Endocrinology and Metabolism. 98: 892-901. PMID 23372173 DOI: 10.1210/jc.2012-3604  0.6
2013 Ren F, Feng X, Ko TP, Huang CH, Hu Y, Chan HC, Liu YL, Wang K, Chen CC, Pang X, He M, Li Y, Oldfield E, Guo RT. Insights into TIM-barrel prenyl transferase mechanisms: crystal structures of PcrB from Bacillus subtilis and Staphylococcus aureus. Chembiochem : a European Journal of Chemical Biology. 14: 195-9. PMID 23322418 DOI: 10.1002/cbic.201200748  1
2013 Span I, Wang K, Wang W, Jauch J, Eisenreich W, Bacher A, Oldfield E, Groll M. Structures of fluoro, amino, and thiol inhibitors bound to the [Fe4S4] protein IspH. Angewandte Chemie (International Ed. in English). 52: 2118-21. PMID 23307751 DOI: 10.1002/anie.201208469  1
2013 Zhu W, Zhang Y, Sinko W, Hensler ME, Olson J, Molohon KJ, Lindert S, Cao R, Li K, Wang K, Wang Y, Liu YL, Sankovsky A, de Oliveira CA, Mitchell DA, ... ... Oldfield E, et al. Antibacterial drug leads targeting isoprenoid biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 123-8. PMID 23248302 DOI: 10.1073/pnas.1219899110  0.92
2013 Johnson DA, Oldfield EC. Reported side effects and complications of long-term proton pump inhibitor use: dissecting the evidence. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 11: 458-64; quiz e37-8. PMID 23247326 DOI: 10.1016/j.cgh.2012.11.031  0.88
2013 Zhang Y, Zhu W, Liu YL, Wang H, Wang K, Li K, No JH, Ayong L, Gulati A, Pang R, Freitas-Junior L, Morita CT, Oldfield E. Chemo-immunotherapeutic antimalarials targeting isoprenoid biosynthesis Acs Medicinal Chemistry Letters. 4: 423-427. DOI: 10.1021/ml4000436  1
2012 Heiss JD, Suffredini G, Bakhtian KD, Sarntinoranont M, Oldfield EH. Normalization of hindbrain morphology after decompression of Chiari malformation Type I. Journal of Neurosurgery. 117: 942-6. PMID 22978540 DOI: 10.3171/2012.8.JNS111476  0.6
2012 Heiss JD, Snyder K, Peterson MM, Patronas NJ, Butman JA, Smith RK, Devroom HL, Sansur CA, Eskioglu E, Kammerer WA, Oldfield EH. Pathophysiology of primary spinal syringomyelia. Journal of Neurosurgery. Spine. 17: 367-80. PMID 22958075 DOI: 10.3171/2012.8.SPINE111059  0.6
2012 Span I, Wang K, Wang W, Zhang Y, Bacher A, Eisenreich W, Li K, Schulz C, Oldfield E, Groll M. Discovery of acetylene hydratase activity of the iron-sulphur protein IspH. Nature Communications. 3: 1042. PMID 22948824 DOI: 10.1038/ncomms2052  1
2012 El Moll H, Zhu W, Oldfield E, Rodriguez-Albelo LM, Mialane P, Marrot J, Vila N, Mbomekallé IM, Rivière E, Duboc C, Dolbecq A. Polyoxometalates functionalized by bisphosphonate ligands: synthesis, structural, magnetic, and spectroscopic characterizations and activity on tumor cell lines. Inorganic Chemistry. 51: 7921-31. PMID 22725619 DOI: 10.1021/ic3010079  1
2012 Wang W, Wang K, Span I, Jauch J, Bacher A, Groll M, Oldfield E. Are free radicals involved in IspH catalysis? An EPR and crystallographic investigation. Journal of the American Chemical Society. 134: 11225-34. PMID 22687151 DOI: 10.1021/ja303445z  1
2012 Zhang Y, Fu-Yang Lin, Li K, Zhu W, Liu YL, Cao R, Pang R, Lee E, Axelson J, Hensler M, Wang K, Molohon KJ, Wang Y, Mitchell DA, Nizet V, ... Oldfield E, et al. HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis. Acs Medicinal Chemistry Letters. 3: 402-406. PMID 22662288 DOI: 10.1021/ml300038t  1
2012 Liu YL, Guerra F, Wang K, Wang W, Li J, Huang C, Zhu W, Houlihan K, Li Z, Zhang Y, Nair SK, Oldfield E. Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins. Proceedings of the National Academy of Sciences of the United States of America. 109: 8558-63. PMID 22586085 DOI: 10.1073/pnas.1121107109  1
2012 Vortmeyer AO, Gläsker S, Mehta GU, Abu-Asab MS, Smith JH, Zhuang Z, Collins MT, Oldfield EH. Somatic GNAS mutation causes widespread and diffuse pituitary disease in acromegalic patients with McCune-Albright syndrome. The Journal of Clinical Endocrinology and Metabolism. 97: 2404-13. PMID 22564667 DOI: 10.1210/jc.2012-1274  0.6
2012 Lin FY, Liu YL, Li K, Cao R, Zhu W, Axelson J, Pang R, Oldfield E. Head-to-head prenyl tranferases: anti-infective drug targets. Journal of Medicinal Chemistry. 55: 4367-72. PMID 22486710 DOI: 10.1021/jm300208p  1
2012 Ren F, Ko TP, Feng X, Huang CH, Chan HC, Hu Y, Wang K, Ma Y, Liang PH, Wang AH, Oldfield E, Guo RT. Insights into the mechanism of the antibiotic-synthesizing enzyme MoeO5 from crystal structures of different complexes. Angewandte Chemie (International Ed. in English). 51: 4157-60. PMID 22431288 DOI: 10.1002/anie.201108002  1
2012 No JH, de Macedo Dossin F, Zhang Y, Liu YL, Zhu W, Feng X, Yoo JA, Lee E, Wang K, Hui R, Freitas-Junior LH, Oldfield E. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proceedings of the National Academy of Sciences of the United States of America. 109: 4058-63. PMID 22392982 DOI: 10.1073/pnas.1118215109  1
2012 Xia Y, Yeddula N, Leblanc M, Ke E, Zhang Y, Oldfield E, Shaw RJ, Verma IM. Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model. Nature Cell Biology. 14: 257-65. PMID 22327365 DOI: 10.1038/ncb2428  1
2012 Lin FY, Zhang Y, Hensler M, Liu YL, Chow OA, Zhu W, Wang K, Pang R, Thienphrapa W, Nizet V, Oldfield E. Dual dehydrosqualene/squalene synthase inhibitors: leads for innate immune system-based therapeutics. Chemmedchem. 7: 561-4. PMID 22290830 DOI: 10.1002/cmdc.201100589  1
2012 Oldfield E, Lin FY. Terpene biosynthesis: modularity rules. Angewandte Chemie (International Ed. in English). 51: 1124-37. PMID 22105807 DOI: 10.1002/anie.201103110  1
2012 Mehta GU, Lonser RR, Oldfield EH. The history of pituitary surgery for Cushing disease. Journal of Neurosurgery. 116: 261-8. PMID 21962161 DOI: 10.3171/2011.8.JNS102005  0.44
2012 Lonser RR, Ksendzovsky A, Wind JJ, Vortmeyer AO, Oldfield EH. Prospective evaluation of the characteristics and incidence of adenoma-associated dural invasion in Cushing disease. Journal of Neurosurgery. 116: 272-9. PMID 21923247 DOI: 10.3171/2011.8.JNS11456  0.6
2012 Liu YL, Guerra F, Wang K, Wang W, Li J, Huang C, Zhu W, Houlihan K, Li Z, Zhang Y, Nair SK, Oldfield E. Structure, function and inhibition of the twoand three-domain 4Fe-4S IspG proteins (Proceedings of the National Academy of Sciences of the United States of America (2012) 109, 22 (8558-8563) DOI: 10.1073/pnas.1121107109) Proceedings of the National Academy of Sciences of the United States of America. 109: 10605. DOI: 10.1073/pnas.1208466109  1
2011 Wang H, Sarikonda G, Puan KJ, Tanaka Y, Feng J, Giner JL, Cao R, Mönkkönen J, Oldfield E, Morita CT. Indirect stimulation of human Vγ2Vδ2 T cells through alterations in isoprenoid metabolism. Journal of Immunology (Baltimore, Md. : 1950). 187: 5099-113. PMID 22013129 DOI: 10.4049/jimmunol.1002697  1
2011 Gläsker S, Vortmeyer AO, Lafferty AR, Hofman PL, Li J, Weil RJ, Zhuang Z, Oldfield EH. Hereditary pituitary hyperplasia with infantile gigantism. The Journal of Clinical Endocrinology and Metabolism. 96: E2078-87. PMID 21976722 DOI: 10.1210/jc.2011-1401  0.6
2011 Wylie BJ, Sperling LJ, Nieuwkoop AJ, Franks WT, Oldfield E, Rienstra CM. Ultrahigh resolution protein structures using NMR chemical shift tensors. Proceedings of the National Academy of Sciences of the United States of America. 108: 16974-9. PMID 21969532 DOI: 10.1073/pnas.1103728108  1
2011 Simone CB, Lonser RR, Ondos J, Oldfield EH, Camphausen K, Simone NL. Infratentorial craniospinal irradiation for von Hippel-Lindau: a retrospective study supporting a new treatment for patients with CNS hemangioblastomas. Neuro-Oncology. 13: 1030-6. PMID 21798886 DOI: 10.1093/neuonc/nor085  0.44
2011 Durrant JD, Cao R, Gorfe AA, Zhu W, Li J, Sankovsky A, Oldfield E, McCammon JA. Non-bisphosphonate inhibitors of isoprenoid biosynthesis identified via computer-aided drug design. Chemical Biology & Drug Design. 78: 323-32. PMID 21696546 DOI: 10.1111/j.1747-0285.2011.01164.x  0.92
2011 Wang W, Wang K, Li J, Nellutla S, Smirnova TI, Oldfield E. An ENDOR and HYSCORE investigation of a reaction intermediate in IspG (GcpE) catalysis. Journal of the American Chemical Society. 133: 8400-3. PMID 21574560 DOI: 10.1021/ja200763a  1
2011 Shively SB, Falke EA, Li J, Tran MG, Thompson ER, Maxwell PH, Roessler E, Oldfield EH, Lonser RR, Vortmeyer AO. Developmentally arrested structures preceding cerebellar tumors in von Hippel-Lindau disease. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 24: 1023-30. PMID 21499240 DOI: 10.1038/modpathol.2011.61  0.6
2011 Wang W, Li J, Wang K, Smirnova TI, Oldfield E. Pyridine inhibitor binding to the 4Fe-4S protein A. aeolicus IspH (LytB): a HYSCORE Investigation. Journal of the American Chemical Society. 133: 6525-8. PMID 21486034 DOI: 10.1021/ja2008455  1
2011 Sinko W, de Oliveira C, Williams S, Van Wynsberghe A, Durrant JD, Cao R, Oldfield E, McCammon JA. Applying molecular dynamics simulations to identify rarely sampled ligand-bound conformational states of undecaprenyl pyrophosphate synthase, an antibacterial target. Chemical Biology & Drug Design. 77: 412-20. PMID 21294851 DOI: 10.1111/j.1747-0285.2011.01101.x  0.92
2011 Asthagiri AR, Mehta GU, Butman JA, Baggenstos M, Oldfield EH, Lonser RR. Long-term stability after multilevel cervical laminectomy for spinal cord tumor resection in von Hippel-Lindau disease. Journal of Neurosurgery. Spine. 14: 444-52. PMID 21275550 DOI: 10.3171/2010.11.SPINE10429  0.6
2011 Pluta RM, Oldfield EH, Bakhtian KD, Fathi AR, Smith RK, Devroom HL, Nahavandi M, Woo S, Figg WD, Lonser RR. Safety and feasibility of long-term intravenous sodium nitrite infusion in healthy volunteers. Plos One. 6: e14504. PMID 21249218 DOI: 10.1371/journal.pone.0014504  0.6
2011 Wind JJ, Bakhtian KD, Sweet JA, Mehta GU, Thawani JP, Asthagiri AR, Oldfield EH, Lonser RR. Long-term outcome after resection of brainstem hemangioblastomas in von Hippel-Lindau disease. Journal of Neurosurgery. 114: 1312-8. PMID 20932100 DOI: 10.3171/2010.9.JNS10839  0.6
2010 Heiss JD, Suffredini G, Smith R, DeVroom HL, Patronas NJ, Butman JA, Thomas F, Oldfield EH. Pathophysiology of persistent syringomyelia after decompressive craniocervical surgery. Clinical article. Journal of Neurosurgery. Spine. 13: 729-42. PMID 21121751 DOI: 10.3171/2010.6.SPINE10200  0.6
2010 Lin FY, Liu CI, Liu YL, Zhang Y, Wang K, Jeng WY, Ko TP, Cao R, Wang AH, Oldfield E. Mechanism of action and inhibition of dehydrosqualene synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 21337-42. PMID 21098670 DOI: 10.1073/pnas.1010907107  1
2010 Compain JD, Mialane P, Marrot J, Sécheresse F, Zhu W, Oldfield E, Dolbecq A. Tetra- to dodecanuclear oxomolybdate complexes with functionalized bisphosphonate ligands: Activity in killing tumor cells Chemistry - a European Journal. 16: 13741-13748. PMID 20957624 DOI: 10.1002/chem.201001626  1
2010 Schatlo B, Dreier JP, Gläsker S, Fathi AR, Moncrief T, Oldfield EH, Vortmeyer AO, Pluta RM. Report of selective cortical infarcts in the primate clot model of vasospasm after subarachnoid hemorrhage. Neurosurgery. 67: 721-8; discussion 72. PMID 20651629 DOI: 10.1227/01.NEU.0000378024.70848.8F  0.44
2010 Lonser RR, Kindzelski BA, Mehta GU, Jane JA, Oldfield EH. Acromegaly without imaging evidence of pituitary adenoma. The Journal of Clinical Endocrinology and Metabolism. 95: 4192-6. PMID 20610592 DOI: 10.1210/jc.2010-0570  0.44
2010 Cao R, Zhang Y, Mann FM, Huang C, Mukkamala D, Hudock MP, Mead ME, Prisic S, Wang K, Lin FY, Chang TK, Peters RJ, Oldfield E. Diterpene cyclases and the nature of the isoprene fold. Proteins. 78: 2417-32. PMID 20602361 DOI: 10.1002/prot.22751  1
2010 Oldfield E. Targeting isoprenoid biosynthesis for drug discovery: bench to bedside. Accounts of Chemical Research. 43: 1216-26. PMID 20560544 DOI: 10.1021/ar100026v  1
2010 Wang W, Li J, Wang K, Huang C, Zhang Y, Oldfield E. Organometallic mechanism of action and inhibition of the 4Fe-4S isoprenoid biosynthesis protein GcpE (IspG). Proceedings of the National Academy of Sciences of the United States of America. 107: 11189-93. PMID 20534554 DOI: 10.1073/pnas.1000264107  1
2010 Ramos IB, Miranda K, Pace DA, Verbist KC, Lin FY, Zhang Y, Oldfield E, Machado EA, De Souza W, Docampo R. Calcium- and polyphosphate-containing acidic granules of sea urchin eggs are similar to acidocalcisomes, but are not the targets for NAADP. The Biochemical Journal. 429: 485-95. PMID 20497125 DOI: 10.1042/BJ20091956  1
2010 Singh AP, Zhang Y, No JH, Docampo R, Nussenzweig V, Oldfield E. Lipophilic bisphosphonates are potent inhibitors of Plasmodium liver-stage growth. Antimicrobial Agents and Chemotherapy. 54: 2987-93. PMID 20457823 DOI: 10.1128/AAC.00198-10  1
2010 Wang K, Wang W, No JH, Zhang Y, Zhang Y, Oldfield E. Inhibition of the Fe(4)S(4)-cluster-containing protein IspH (LytB): electron paramagnetic resonance, metallacycles, and mechanisms. Journal of the American Chemical Society. 132: 6719-27. PMID 20426416 DOI: 10.1021/ja909664j  1
2010 Mehta GU, Asthagiri AR, Bakhtian KD, Auh S, Oldfield EH, Lonser RR. Functional outcome after resection of spinal cord hemangioblastomas associated with von Hippel-Lindau disease. Journal of Neurosurgery. Spine. 12: 233-42. PMID 20192620 DOI: 10.3171/2009.10.SPINE09592  0.6
2010 Wang W, Wang K, Liu YL, No JH, Li J, Nilges MJ, Oldfield E. Bioorganometallic mechanism of action, and inhibition, of IspH. Proceedings of the National Academy of Sciences of the United States of America. 107: 4522-7. PMID 20173096 DOI: 10.1073/pnas.0911087107  1
2010 Nobre LS, Todorovic S, Tavares AF, Oldfield E, Hildebrandt P, Teixeira M, Saraiva LM. Binding of azole antibiotics to Staphylococcus aureus flavohemoglobin increases intracellular oxidative stress. Journal of Bacteriology. 192: 1527-33. PMID 20097858 DOI: 10.1128/JB.01378-09  1
2010 Zhang Y, Cao R, Yin F, Lin FY, Wang H, Krysiak K, No JH, Mukkamala D, Houlihan K, Li J, Morita CT, Oldfield E. Lipophilic pyridinium bisphosphonates: potent gammadelta T cell stimulators. Angewandte Chemie (International Ed. in English). 49: 1136-8. PMID 20039246 DOI: 10.1002/anie.200905933  1
2010 Huang CH, Gabelli SB, Oldfield E, Amzel LM. Binding of nitrogen-containing bisphosphonates (N-BPs) to the Trypanosoma cruzi farnesyl diphosphate synthase homodimer. Proteins. 78: 888-99. PMID 19876942 DOI: 10.1002/prot.22614  1
2010 Chowdhury IN, Sinaii N, Oldfield EH, Patronas N, Nieman LK. A change in pituitary magnetic resonance imaging protocol detects ACTH-secreting tumours in patients with previously negative results. Clinical Endocrinology. 72: 502-6. PMID 19500112 DOI: 10.1111/j.1365-2265.2009.03646.x  0.6
2009 Olivier AC, Lemaire S, Van Bambeke F, Tulkens PM, Oldfield E. Role of rsbU and staphyloxanthin in phagocytosis and intracellular growth of Staphylococcus aureus in human macrophages and endothelial cells. The Journal of Infectious Diseases. 200: 1367-70. PMID 19817587 DOI: 10.1086/606012  1
2009 Alper O, Stetler-Stevenson WG, Harris LN, Leitner WW, Ozdemirli M, Hartmann D, Raffeld M, Abu-Asab M, Byers S, Zhuang Z, Oldfield EH, Tong Y, Bergmann-Leitner E, Criss WE, Nagasaki K, et al. Novel anti-filamin-A antibody detects a secreted variant of filamin-A in plasma from patients with breast carcinoma and high-grade astrocytoma. Cancer Science. 100: 1748-56. PMID 19594548 DOI: 10.1111/j.1349-7006.2009.01244.x  0.6
2009 Mukherjee S, Huang C, Guerra F, Wang K, Oldfield E. Thermodynamics of bisphosphonates binding to human bone: a two-site model. Journal of the American Chemical Society. 131: 8374-5. PMID 19489581 DOI: 10.1021/ja902895p  1
2009 Song Y, Liu CI, Lin FY, No JH, Hensler M, Liu YL, Jeng WY, Low J, Liu GY, Nizet V, Wang AH, Oldfield E. Inhibition of staphyloxanthin virulence factor biosynthesis in Staphylococcus aureus: in vitro, in vivo, and crystallographic results. Journal of Medicinal Chemistry. 52: 3869-80. PMID 19456099 DOI: 10.1021/jm9001764  1
2009 Pluta RM, Butman JA, Schatlo B, Johnson DL, Oldfield EH. Subarachnoid hemorrhage and the distribution of drugs delivered into the cerebrospinal fluid. Laboratory investigation. Journal of Neurosurgery. 111: 1001-7, 1-4. PMID 19374502 DOI: 10.3171/2009.2.JNS081256  0.6
2009 Zhang Y, Cao R, Yin F, Hudock MP, Guo RT, Krysiak K, Mukherjee S, Gao YG, Robinson H, Song Y, No JH, Bergan K, Leon A, Cass L, Goddard A, ... ... Oldfield E, et al. Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation. Journal of the American Chemical Society. 131: 5153-62. PMID 19309137 DOI: 10.1021/ja808285e  0.76
2009 Jagannathan J, Smith R, DeVroom HL, Vortmeyer AO, Stratakis CA, Nieman LK, Oldfield EH. Outcome of using the histological pseudocapsule as a surgical capsule in Cushing disease. Journal of Neurosurgery. 111: 531-9. PMID 19267526 DOI: 10.3171/2008.8.JNS08339  0.6
2009 Song Y, Lin FY, Yin F, Hensler M, Rodrígues Poveda CA, Mukkamala D, Cao R, Wang H, Morita CT, González Pacanowska D, Nizet V, Oldfield E. Phosphonosulfonates are potent, selective inhibitors of dehydrosqualene synthase and staphyloxanthin biosynthesis in Staphylococcus aureus. Journal of Medicinal Chemistry. 52: 976-88. PMID 19191557 DOI: 10.1021/jm801023u  1
2009 Gao S, Mioc D, Yi X, Anton F, Oldfield E, Coleman DJ. Towards Web-based representation and processing of health information. International Journal of Health Geographics. 8: 3. PMID 19159445 DOI: 10.1186/1476-072X-8-3  0.32
2009 Jagannathan J, Li J, Szerlip N, Vortmeyer AO, Lonser RR, Oldfield EH, Zhuang Z. Application and implementation of selective tissue microdissection and proteomic profiling in neurological disease. Neurosurgery. 64: 4-14; discussion 14. PMID 19145153 DOI: 10.1227/01.NEU.0000335776.93176.83  0.64
2009 Wylie BJ, Schwieters CD, Oldfield E, Rienstra CM. Protein structure refinement using 13C alpha chemical shift tensors. Journal of the American Chemical Society. 131: 985-92. PMID 19123862 DOI: 10.1021/ja804041p  1
2009 Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. Photoaffinity antigens for human γδ T cells Journal of Immunology. 181: 7738-7750.  1
2008 Mukkamala D, No JH, Cass LM, Chang TK, Oldfield E. Bisphosphonate inhibition of a Plasmodium farnesyl diphosphate synthase and a general method for predicting cell-based activity from enzyme data. Journal of Medicinal Chemistry. 51: 7827-33. PMID 19053772 DOI: 10.1021/jm8009074  1
2008 Rekittke I, Wiesner J, Röhrich R, Demmer U, Warkentin E, Xu W, Troschke K, Hintz M, No JH, Duin EC, Oldfield E, Jomaa H, Ermler U. Structure of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate reductase, the terminal enzyme of the non-mevalonate pathway. Journal of the American Chemical Society. 130: 17206-7. PMID 19035630 DOI: 10.1021/ja806668q  1
2008 Sarikonda G, Wang H, Puan KJ, Liu XH, Lee HK, Song Y, Distefano MD, Oldfield E, Prestwich GD, Morita CT. Photoaffinity antigens for human gammadelta T cells. Journal of Immunology (Baltimore, Md. : 1950). 181: 7738-50. PMID 19017963  1
2008 Mehta GU, Shively SB, Duong H, Tran MG, Moncrief TJ, Smith JH, Li J, Edwards NA, Lonser RR, Zhuang Z, Merrill MJ, Raffeld M, Maxwell PH, Oldfield EH, Vortmeyer AO. Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease. Neoplasia (New York, N.Y.). 10: 1146-53. PMID 18813354  0.88
2008 K-M Chen C, Hudock MP, Zhang Y, Guo RT, Cao R, No JH, Liang PH, Ko TP, Chang TH, Chang SC, Song Y, Axelson J, Kumar A, Wang AH, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation. Journal of Medicinal Chemistry. 51: 5594-607. PMID 18800762 DOI: 10.1021/jm800325y  1
2008 Song Y, Chan JM, Tovian Z, Secrest A, Nagy E, Krysiak K, Bergan K, Parniak MA, Oldfield E. Bisphosphonate inhibitors of ATP-mediated HIV-1 reverse transcriptase catalyzed excision of chain-terminating 3'-azido, 3'-deoxythymidine: a QSAR investigation. Bioorganic & Medicinal Chemistry. 16: 8959-67. PMID 18789701 DOI: 10.1016/j.bmc.2008.08.047  1
2008 Li J, Okamoto H, Yin C, Jagannathan J, Takizawa J, Aoki S, Gläsker S, Rushing EJ, Vortmeyer AO, Oldfield EH, Yamanaka R, Zhuang Z. Proteomic characterization of primary diffuse large B-cell lymphomas in the central nervous system. Journal of Neurosurgery. 109: 536-46. PMID 18759588 DOI: 10.3171/JNS/2008/109/9/0536  0.88
2008 Cao R, Chen CK, Guo RT, Wang AH, Oldfield E. Structures of a potent phenylalkyl bisphosphonate inhibitor bound to farnesyl and geranylgeranyl diphosphate synthases. Proteins. 73: 431-9. PMID 18442135 DOI: 10.1002/prot.22066  1
2008 Zhang Y, Oldfield E. NMR hyperfine shifts in blue copper proteins: a quantum chemical investigation. Journal of the American Chemical Society. 130: 3814-23. PMID 18314973 DOI: 10.1021/ja075978b  1
2008 Liu CI, Liu GY, Song Y, Yin F, Hensler ME, Jeng WY, Nizet V, Wang AH, Oldfield E. A cholesterol biosynthesis inhibitor blocks Staphylococcus aureus virulence. Science (New York, N.Y.). 319: 1391-4. PMID 18276850 DOI: 10.1126/science.1153018  1
2008 Li J, Yin C, Okamoto H, Mushlin H, Balgley BM, Lee CS, Yuan K, Ikejiri B, Glasker S, Vortmeyer AO, Oldfield EH, Weil RJ, Zhuang Z. Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas. Neuro-Oncology. 10: 45-51. PMID 18182627 DOI: 10.1215/15228517-2007-036  0.6
2008 Mukherjee S, Song Y, Oldfield E. NMR investigations of the static and dynamic structures of bisphosphonates on human bone: a molecular model. Journal of the American Chemical Society. 130: 1264-73. PMID 18173269 DOI: 10.1021/ja0759949  1
2008 Babu PK, Chung JH, Oldfield E, Wieckowski A. CO surface diffusion on platinum fuel cell catalysts by electrochemical NMR Electrochimica Acta. 53: 6672-6679. DOI: 10.1016/j.electacta.2008.02.046  1
2007 Zhang Y, Hudock MP, Krysiak K, Cao R, Bergan K, Yin F, Leon A, Oldfield E. Activity of sulfonium bisphosphonates on tumor cell lines. Journal of Medicinal Chemistry. 50: 6067-79. PMID 17963374 DOI: 10.1021/jm700991k  1
2007 Ling Y, Li ZH, Miranda K, Oldfield E, Moreno SN. The farnesyl-diphosphate/geranylgeranyl-diphosphate synthase of Toxoplasma gondii is a bifunctional enzyme and a molecular target of bisphosphonates. The Journal of Biological Chemistry. 282: 30804-16. PMID 17724033 DOI: 10.1074/jbc.M703178200  1
2007 Guo RT, Cao R, Liang PH, Ko TP, Chang TH, Hudock MP, Jeng WY, Chen CK, Zhang Y, Song Y, Kuo CJ, Yin F, Oldfield E, Wang AH. Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases. Proceedings of the National Academy of Sciences of the United States of America. 104: 10022-7. PMID 17535895 DOI: 10.1073/pnas.0702254104  1
2007 Mukkamala D, Zhang Y, Oldfield E. A solid state 13C NMR, crystallographic, and quantum chemical investigation of phenylalanine and tyrosine residues in dipeptides and proteins. Journal of the American Chemical Society. 129: 7385-92. PMID 17506558 DOI: 10.1021/ja071227y  1
2007 Gläsker S, Lonser RR, Okamoto H, Li J, Jaffee H, Oldfield EH, Zhuang Z, Vortmeyer AO. Proteomic profiling: a novel method for differential diagnosis? Cancer Biology & Therapy. 6: 343-5. PMID 17471020  0.88
2007 Sanz-Rodríguez CE, Concepción JL, Pekerar S, Oldfield E, Urbina JA. Bisphosphonates as inhibitors of Trypanosoma cruzi hexokinase: kinetic and metabolic studies. The Journal of Biological Chemistry. 282: 12377-87. PMID 17329254 DOI: 10.1074/jbc.M607286200  1
2007 Park DM, Li J, Okamoto H, Akeju O, Kim SH, Lubensky I, Vortmeyer A, Dambrosia J, Weil RJ, Oldfield EH, Park JK, Zhuang Z. N-CoR pathway targeting induces glioblastoma derived cancer stem cell differentiation. Cell Cycle (Georgetown, Tex.). 6: 467-70. PMID 17312396  0.6
2007 Park DM, Zhuang Z, Chen L, Szerlip N, Maric I, Li J, Sohn T, Kim SH, Lubensky IA, Vortmeyer AO, Rodgers GP, Oldfield EH, Lonser RR. von Hippel-Lindau disease-associated hemangioblastomas are derived from embryologic multipotent cells. Plos Medicine. 4: e60. PMID 17298169 DOI: 10.1371/journal.pmed.0040060  0.6
2007 Okamoto H, Li J, Gläsker S, Vortmeyer AO, Jaffe H, Robison RA, Bogler O, Mikkelsen T, Lubensky IA, Oldfield EH, Zhuang Z. Proteomic comparison of oligodendrogliomas with and without 1pLOH. Cancer Biology & Therapy. 6: 391-6. PMID 17264672  0.6
2007 Babu PK, Kobayashi T, Chung H, Oldfield E, Wieckowski A. Coverage dependence of CO surface diffusion on Pt nanoparticles: An EC-NMR study Acs National Meeting Book of Abstracts. DOI: 10.1021/jp066803b  1
2007 Babu PK, Lewera A, Jong HC, Hunger R, Jaegermann W, Alonso-Vante N, Wieckowski A, Oldfield E. Selenium becomes metallic in Ru-Se fuel cell catalysts: An EC-NMR and XPS investigation Journal of the American Chemical Society. 129: 15140-15141. DOI: 10.1021/ja077498q  1
2007 Babu PK, Kobayashi T, Chung H, Oldfield E, Wieckowski A. Coverage dependence of CO surface diffusion on Pt nanoparticles: An EC-NMR study Acs National Meeting Book of Abstracts 1
2007 Wieckowski A, Kobayashi T, Babu PK, Chung JH, Oldfield E. Coverage dependence of CO surface diffusion on Pt nanoparticles - An EC-NMR study Materials Research Society Symposium Proceedings. 984: 147-158.  1
2006 Kotsikorou E, Sahota G, Oldfield E. Bisphosphonate inhibition of phosphoglycerate kinase: quantitative structure-activity relationship and pharmacophore modeling investigation. Journal of Medicinal Chemistry. 49: 6692-703. PMID 17154500 DOI: 10.1021/jm0604833  1
2006 Leon A, Liu L, Yang Y, Hudock MP, Hall P, Yin F, Studer D, Puan KJ, Morita CT, Oldfield E. Isoprenoid biosynthesis as a drug target: bisphosphonate inhibition of Escherichia coli K12 growth and synergistic effects of fosmidomycin. Journal of Medicinal Chemistry. 49: 7331-41. PMID 17149863 DOI: 10.1021/jm060492b  1
2006 Mao J, Mukherjee S, Zhang Y, Cao R, Sanders JM, Song Y, Zhang Y, Meints GA, Gao YG, Mukkamala D, Hudock MP, Oldfield E. Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes. Journal of the American Chemical Society. 128: 14485-97. PMID 17090032 DOI: 10.1021/ja061737c  1
2006 Yano H, Inukai J, Uchida H, Watanabe M, Babu PK, Kobayashi T, Chung JH, Oldfield E, Wieckowski A. Particle-size effect of nanoscale platinum catalysts in oxygen reduction reaction: An electrochemical and 195Pt EC-NMR study Physical Chemistry Chemical Physics. 8: 4932-4939. PMID 17066184 DOI: 10.1039/b610573d  1
2006 Okamoto H, Li J, Vortmeyer AO, Jaffe H, Lee YS, Gläsker S, Sohn TS, Zeng W, Ikejiri B, Proescholdt MA, Mayer C, Weil RJ, Oldfield EH, Zhuang Z. Comparative proteomic profiles of meningioma subtypes. Cancer Research. 66: 10199-204. PMID 17047085 DOI: 10.1158/0008-5472.CAN-06-0955  0.88
2006 Kervern G, Pintacuda G, Zhang Y, Oldfield E, Roukoss C, Kuntz E, Herdtweck E, Basset JM, Cadars S, Lesage A, Copéret C, Emsley L. Solid-state NMR of a paramagnetic DIAD-FeII catalyst: sensitivity, resolution enhancement, and structure-based assignments. Journal of the American Chemical Society. 128: 13545-52. PMID 17031968 DOI: 10.1021/ja063510n  1
2006 Zhang Y, Song Y, Yin F, Broderick E, Siegel K, Goddard A, Nieves E, Pasa-Tolic L, Tanaka Y, Wang H, Morita CT, Oldfield E. Structural studies of Vgamma2Vdelta2 T cell phosphoantigens. Chemistry & Biology. 13: 985-92. PMID 16984888 DOI: 10.1016/j.chembiol.2006.08.007  1
2006 Zhang Y, Leon A, Song Y, Studer D, Haase C, Koscielski LA, Oldfield E. Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines. Journal of Medicinal Chemistry. 49: 5804-14. PMID 16970405 DOI: 10.1021/jm060280e  1
2006 Li J, Yin C, Okamoto H, Jaffe H, Oldfield EH, Zhuang Z, Vortmeyer AO, Rushing EJ. Proteomic analysis of inclusion body myositis. Journal of Neuropathology and Experimental Neurology. 65: 826-33. PMID 16896316 DOI: 10.1097/01.jnen.0000228204.19915.69  0.88
2006 Gläsker S, Vortmeyer AO, Lonser RR, Lubensky IA, Okamoto H, Xia JB, Li J, Milne E, Kowalak JA, Oldfield EH, Zhuang Z. Proteomic analysis of hemangioblastoma cyst fluid. Cancer Biology & Therapy. 5: 549-53. PMID 16627978  0.88
2006 Gläsker S, Li J, Xia JB, Okamoto H, Zeng W, Lonser RR, Zhuang Z, Oldfield EH, Vortmeyer AO. Hemangioblastomas share protein expression with embryonal hemangioblast progenitor cell. Cancer Research. 66: 4167-72. PMID 16618738 DOI: 10.1158/0008-5472.CAN-05-3505  0.88
2006 Yin F, Cao R, Goddard A, Zhang Y, Oldfield E. Enthalpy versus entropy-driven binding of bisphosphonates to farnesyl diphosphate synthase. Journal of the American Chemical Society. 128: 3524-5. PMID 16536518 DOI: 10.1021/ja0601639  1
2006 Li J, Zhuang Z, Okamoto H, Vortmeyer AO, Park DM, Furuta M, Lee YS, Oldfield EH, Zeng W, Weil RJ. Proteomic profiling distinguishes astrocytomas and identifies differential tumor markers. Neurology. 66: 733-6. PMID 16534112 DOI: 10.1212/01.wnl.0000201270.90502.d0  0.6
2006 Lubensky IA, Vortmeyer AO, Kim S, Lonser RR, Park DM, Ikejiri B, Li J, Okamoto H, Walbridge S, Ryschkewitsch C, Major E, Oldfield EH, Zhuang Z. Identification of tumor precursor cells in the brains of primates with radiation-induced de novo glioblastoma multiforme. Cell Cycle (Georgetown, Tex.). 5: 452-6. PMID 16479164  0.6
2006 Zhang Y, Oldfield E. 31P NMR chemical shifts in hypervalent oxyphosphoranes and polymeric orthophosphates. The Journal of Physical Chemistry. B. 110: 579-86. PMID 16471570 DOI: 10.1021/jp054022p  0.88
2006 Benaim G, Sanders JM, Garcia-Marchán Y, Colina C, Lira R, Caldera AR, Payares G, Sanoja C, Burgos JM, Leon-Rossell A, Concepcion JL, Schijman AG, Levin M, Oldfield E, Urbina JA. Amiodarone has intrinsic anti-Trypanosoma cruzi activity and acts synergistically with posaconazole. Journal of Medicinal Chemistry. 49: 892-9. PMID 16451055 DOI: 10.1021/jm050691f  1
2006 Hudock MP, Sanz-Rodríguez CE, Song Y, Chan JM, Zhang Y, Odeh S, Kosztowski T, Leon-Rossell A, Concepción JL, Yardley V, Croft SL, Urbina JA, Oldfield E. Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. Journal of Medicinal Chemistry. 49: 215-23. PMID 16392806 DOI: 10.1021/jm0582625  1
2006 Gabelli SB, McLellan JS, Montalvetti A, Oldfield E, Docampo R, Amzel LM. Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: implications for drug design. Proteins. 62: 80-8. PMID 16288456 DOI: 10.1002/prot.20754  1
2006 Gläsker S, Sohn TS, Okamoto H, Li J, Lonser RR, Oldfield EH, Vortmeyer AO, Zhuang Z. Second hit deletion size in von Hippel-Lindau disease. Annals of Neurology. 59: 105-10. PMID 16261628 DOI: 10.1002/ana.20704  0.88
2005 Babu PK, Chung JH, Kuk ST, Kobayashi T, Oldfield E, Wieckowski A. Metallic nature and surface diffusion of CO adsorbed on Ru nanoparticles in aqueous media: A 13C NMR study. The Journal of Physical Chemistry. B. 109: 2474-7. PMID 16851244 DOI: 10.1021/jp040729k  1
2005 Pack SD, Weil RJ, Vortmeyer AO, Zeng W, Li J, Okamoto H, Furuta M, Pak E, Lubensky IA, Oldfield EH, Zhuang Z. Individual adult human neurons display aneuploidy: detection by fluorescence in situ hybridization and single neuron PCR. Cell Cycle (Georgetown, Tex.). 4: 1758-60. PMID 16258289  0.88
2005 Kobayashi T, Babu PK, Gancs L, Chung JH, Oldfield E, Wieckowski A. An NMR determination of CO diffusion on platinum electrocatalysts Journal of the American Chemical Society. 127: 14164-14165. PMID 16218593 DOI: 10.1021/ja0550475  1
2005 Kotsikorou E, Song Y, Chan JM, Faelens S, Tovian Z, Broderick E, Bakalara N, Docampo R, Oldfield E. Bisphosphonate inhibition of the exopolyphosphatase activity of the Trypanosoma brucei soluble vacuolar pyrophosphatase. Journal of Medicinal Chemistry. 48: 6128-39. PMID 16162013 DOI: 10.1021/jm058220g  1
2005 Cheng F, Sun H, Zhang Y, Mukkamala D, Oldfield E. A solid state 13C NMR, crystallographic, and quantum chemical investigation of chemical shifts and hydrogen bonding in histidine dipeptides. Journal of the American Chemical Society. 127: 12544-54. PMID 16144402 DOI: 10.1021/ja051528c  1
2005 Vogel TW, Zhuang Z, Li J, Okamoto H, Furuta M, Lee YS, Zeng W, Oldfield EH, Vortmeyer AO, Weil RJ. Proteins and protein pattern differences between glioma cell lines and glioblastoma multiforme. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 11: 3624-32. PMID 15897557 DOI: 10.1158/1078-0432.CCR-04-2115  0.88
2005 Ling Y, Sahota G, Odeh S, Chan JM, Araujo FG, Moreno SN, Oldfield E. Bisphosphonate inhibitors of Toxoplasma gondi growth: in vitro, QSAR, and in vivo investigations. Journal of Medicinal Chemistry. 48: 3130-40. PMID 15857119 DOI: 10.1021/jm040132t  0.68
2005 Wi S, Sun H, Oldfield E, Hong M. Solid-state NMR and quantum chemical investigations of 13Calpha shielding tensor magnitudes and orientations in peptides: determining phi and psi torsion angles. Journal of the American Chemical Society. 127: 6451-8. PMID 15853353 DOI: 10.1021/ja042935b  1
2005 Sanders JM, Song Y, Chan JM, Zhang Y, Jennings S, Kosztowski T, Odeh S, Flessner R, Schwerdtfeger C, Kotsikorou E, Meints GA, Gómez AO, González-Pacanowska D, Raker AM, Wang H, ... ... Oldfield E, et al. Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption. Journal of Medicinal Chemistry. 48: 2957-63. PMID 15828834 DOI: 10.1021/jm040209d  1
2005 Zhang Y, Sun H, Oldfield E. Solid-state NMR fermi contact and dipolar shifts in organometallic complexes and metalloporphyrins. Journal of the American Chemical Society. 127: 3652-3. PMID 15771472 DOI: 10.1021/ja043461j  1
2005 Zhang Y, Mukherjee S, Oldfield E. (67)Zn NMR chemical shifts and electric field gradients in zinc complexes: a quantum chemical investigation. Journal of the American Chemical Society. 127: 2370-1. PMID 15724973 DOI: 10.1021/ja040242p  0.88
2005 Wouters J, Yin F, Song Y, Zhang Y, Oudjama Y, Stalon V, Droogmans L, Morita CT, Oldfield E. A crystallographic investigation of phosphoantigen binding to isopentenyl pyrophosphate/dimethylallyl pyrophosphate isomerase. Journal of the American Chemical Society. 127: 536-7. PMID 15643873 DOI: 10.1021/ja040207i  1
2004 Cheng F, Oldfield E. Inhibition of isoprene biosynthesis pathway enzymes by phosphonates, bisphosphonates, and diphosphates. Journal of Medicinal Chemistry. 47: 5149-58. PMID 15456258 DOI: 10.1021/jm040036s  0.64
2004 Mao J, Gao YG, Odeh S, Robinson H, Montalvetti A, Docampo R, Oldfield E. Crystallization and preliminary X-ray diffraction study of the farnesyl diphosphate synthase from Trypanosoma brucei. Acta Crystallographica. Section D, Biological Crystallography. 60: 1863-6. PMID 15388934 DOI: 10.1107/S0907444904020633  0.88
2004 Seufferheld M, Lea CR, Vieira M, Oldfield E, Docampo R. The H(+)-pyrophosphatase of Rhodospirillum rubrum is predominantly located in polyphosphate-rich acidocalcisomes. The Journal of Biological Chemistry. 279: 51193-202. PMID 15371423 DOI: 10.1074/jbc.M406099200  1
2004 Song Y, Zhang Y, Wang H, Raker AM, Sanders JM, Broderick E, Clark A, Morita CT, Oldfield E. Synthesis of chiral phosphoantigens and their activity in gamma delta T cell stimulation. Bioorganic & Medicinal Chemistry Letters. 14: 4471-7. PMID 15357974 DOI: 10.1016/j.bmcl.2004.06.052  1
2004 Yajima S, Hara K, Sanders JM, Yin F, Ohsawa K, Wiesner J, Jomaa H, Oldfield E. Crystallographic structures of two bisphosphonate:1-deoxyxylulose-5-phosphate reductoisomerase complexes. Journal of the American Chemical Society. 126: 10824-5. PMID 15339150 DOI: 10.1021/ja040126m  1
2004 Ruiz FA, Lea CR, Oldfield E, Docampo R. Human platelet dense granules contain polyphosphate and are similar to acidocalcisomes of bacteria and unicellular eukaryotes. The Journal of Biological Chemistry. 279: 44250-7. PMID 15308650 DOI: 10.1074/jbc.M406261200  1
2004 Zhang Y, Oldfield E. On the Mössbauer spectra of isopenicillin N synthase and a model (FeNO)7 (S = 3/2) system. Journal of the American Chemical Society. 126: 9494-5. PMID 15291525 DOI: 10.1021/ja0401242  0.88
2004 Garzoni LR, Waghabi MC, Baptista MM, de Castro SL, Meirelles Mde N, Britto CC, Docampo R, Oldfield E, Urbina JA. Antiparasitic activity of risedronate in a murine model of acute Chagas' disease. International Journal of Antimicrobial Agents. 23: 286-90. PMID 15164970  0.88
2004 Garzoni LR, Caldera A, Meirelles Mde N, de Castro SL, Docampo R, Meints GA, Oldfield E, Urbina JA. Selective in vitro effects of the farnesyl pyrophosphate synthase inhibitor risedronate on Trypanosoma cruzi. International Journal of Antimicrobial Agents. 23: 273-85. PMID 15164969 DOI: 10.1016/j.ijantimicag.2003.07.020  1
2004 Sun H, Oldfield E. Tryptophan chemical shift in peptides and proteins: a solid state carbon-13 nuclear magnetic resonance spectroscopic and quantum chemical investigation. Journal of the American Chemical Society. 126: 4726-34. PMID 15070392 DOI: 10.1021/ja030612u  1
2004 Zhang Y, Oldfield E. Cytochrome P450: an investigation of the Mössbauer spectra of a reaction intermediate and an Fe(IV)[double bond]O model system. Journal of the American Chemical Society. 126: 4470-1. PMID 15070336 DOI: 10.1021/ja030664j  0.88
2004 Sanders JM, Ghosh S, Chan JM, Meints G, Wang H, Raker AM, Song Y, Colantino A, Burzynska A, Kafarski P, Morita CT, Oldfield E. Quantitative structure-activity relationships for gammadelta T cell activation by bisphosphonates. Journal of Medicinal Chemistry. 47: 375-84. PMID 14711309 DOI: 10.1021/jm0303709  1
2004 Ghosh S, Chan JM, Lea CR, Meints GA, Lewis JC, Tovian ZS, Flessner RM, Loftus TC, Bruchhaus I, Kendrick H, Croft SL, Kemp RG, Kobayashi S, Nozaki T, Oldfield E. Effects of bisphosphonates on the growth of Entamoeba histolytica and Plasmodium species in vitro and in vivo. Journal of Medicinal Chemistry. 47: 175-87. PMID 14695831 DOI: 10.1021/jm030084x  1
2003 Zhang Y, Gossman W, Oldfield E. A density functional theory investigation of Fe-N-O bonding in heme proteins and model systems. Journal of the American Chemical Society. 125: 16387-96. PMID 14692781 DOI: 10.1021/ja030340v  0.88
2003 Sanders JM, Gómez AO, Mao J, Meints GA, Van Brussel EM, Burzynska A, Kafarski P, González-Pacanowska D, Oldfield E. 3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates. Journal of Medicinal Chemistry. 46: 5171-83. PMID 14613320 DOI: 10.1021/jm0302344  1
2003 Kotsikorou E, Oldfield E. A quantitative structure-activity relationship and pharmacophore modeling investigation of aryl-X and heterocyclic bisphosphonates as bone resorption agents. Journal of Medicinal Chemistry. 46: 2932-44. PMID 12825934 DOI: 10.1021/jm030054u  1
2003 Wouters J, Oudjama Y, Ghosh S, Stalon V, Droogmans L, Oldfield E. Structure and mechanism of action of isopentenylpyrophosphate-dimethylallylpyrophosphate isomerase. Journal of the American Chemical Society. 125: 3198-9. PMID 12630859 DOI: 10.1021/ja029171p  0.52
2003 Montalvetti A, Fernandez A, Sanders JM, Ghosh S, Van Brussel E, Oldfield E, Docampo R. Farnesyl pyrophosphate synthase is an essential enzyme in Trypanosoma brucei. In vitro RNA interference and in vivo inhibition studies. The Journal of Biological Chemistry. 278: 17075-83. PMID 12618430 DOI: 10.1074/jbc.M210467200  1
2003 Van Brussel EM, Gossman WL, Wilson SR, Oldfield E. Hydronium (cycloheptylammonio)methylene-1,1-bisphosphonate (hydronium incadronate). Acta Crystallographica. Section C, Crystal Structure Communications. 59: o93-4. PMID 12574666  0.52
2003 Gossman WL, Wilson SR, Oldfield E. Three hydrates of the bisphosphonate risedronate, consisting of one molecular and two ionic structures. Acta Crystallographica. Section C, Crystal Structure Communications. 59: m33-6. PMID 12574640  0.32
2002 Gossman WL, Wilson SR, Oldfield E. Monosodium [1-hydroxy-2-(1H-imidazol-3-ium-4-yl)ethane-1,1-diyl]bis(phosphonate) tetrahydrate (monosodium isozoledronate). Acta Crystallographica. Section C, Crystal Structure Communications. 58: m599-600. PMID 12466610  0.32
2002 Zhang Y, Mao J, Godbout N, Oldfield E. Mössbauer quadrupole splittings and electronic structure in heme proteins and model systems: a density functional theory investigation. Journal of the American Chemical Society. 124: 13921-30. PMID 12431124 DOI: 10.1021/ja020298o  1
2002 Mao J, Zhang Y, Oldfield E. Nuclear magnetic resonance shifts in paramagnetic metalloporphyrins and metalloproteins. Journal of the American Chemical Society. 124: 13911-20. PMID 12431123  0.88
2002 Gossman W, Oldfield E. Quantitative structure--activity relations for gammadelta T cell activation by phosphoantigens. Journal of Medicinal Chemistry. 45: 4868-74. PMID 12383012  0.32
2002 Moreno B, Rodrigues CO, Bailey BN, Urbina JA, Moreno SN, Docampo R, Oldfield E. Magic-angle spinning (31)P NMR spectroscopy of condensed phosphates in parasitic protozoa: visualizing the invisible. Febs Letters. 523: 207-12. PMID 12123833 DOI: 10.1016/S0014-5793(02)02977-0  1
2002 Rodriguez N, Bailey BN, Martin MB, Oldfield E, Urbina JA, Docampo R. Radical cure of experimental cutaneous leishmaniasis by the bisphosphonate pamidronate. The Journal of Infectious Diseases. 186: 138-40. PMID 12089677 DOI: 10.1086/341074  1
2002 Martin MB, Sanders JM, Kendrick H, de Luca-Fradley K, Lewis JC, Grimley JS, Van Brussel EM, Olsen JR, Meints GA, Burzynska A, Kafarski P, Croft SL, Oldfield E. Activity of bisphosphonates against Trypanosoma brucei rhodesiense. Journal of Medicinal Chemistry. 45: 2904-14. PMID 12086478 DOI: 10.1021/jm0102809  1
2002 Szabo CM, Martin MB, Oldfield E. An investigation of bone resorption and Dictyostelium discoideum growth inhibition by bisphosphonate drugs. Journal of Medicinal Chemistry. 45: 2894-903. PMID 12086477 DOI: 10.1021/jm010279+  1
2002 Zhang Y, Mao J, Oldfield E. (57)Fe Mössbauer isomer shifts of heme protein model systems: electronic structure calculations. Journal of the American Chemical Society. 124: 7829-39. PMID 12083937  0.88
2002 Szabo CM, Matsumura Y, Fukura S, Martin MB, Sanders JM, Sengupta S, Cieslak JA, Loftus TC, Lea CR, Lee HJ, Koohang A, Coates RM, Sagami H, Oldfield E. Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates and diphosphates: a potential route to new bone antiresorption and antiparasitic agents. Journal of Medicinal Chemistry. 45: 2185-96. PMID 12014956 DOI: 10.1021/jm010412y  1
2002 Sun H, Sanders LK, Oldfield E. Carbon-13 NMR shielding in the twenty common amino acids: comparisons with experimental results in proteins. Journal of the American Chemical Society. 124: 5486-95. PMID 11996591 DOI: 10.1021/ja011863a  1
2002 Yardley V, Khan AA, Martin MB, Slifer TR, Araujo FG, Moreno SN, Docampo R, Croft SL, Oldfield E. In vivo activities of farnesyl pyrophosphate synthase inhibitors against Leishmania donovani and Toxoplasma gondii. Antimicrobial Agents and Chemotherapy. 46: 929-31. PMID 11850291 DOI: 10.1128/AAC.46.3.929-931.2002  1
2002 Tong Y, Kim HS, Babu PK, Waszczuk P, Wieckowski A, Oldfield E. An NMR investigation of CO tolerance in a Pt/Ru fuel cell catalyst. Journal of the American Chemical Society. 124: 468-73. PMID 11792218 DOI: 10.1021/ja011729q  1
2001 Havlin RH, Laws DD, Bitter HM, Sanders LK, Sun H, Grimley JS, Wemmer DE, Pines A, Oldfield E. An experimental and theoretical investigation of the chemical shielding tensors of (13)C(alpha) of alanine, valine, and leucine residues in solid peptides and in proteins in solution. Journal of the American Chemical Society. 123: 10362-9. PMID 11603987 DOI: 10.1021/ja0115060  1
2001 Szabo CM, Oldfield E. An investigation of bisphosphonate inhibition of a vacuolar proton-pumping pyrophosphatase. Biochemical and Biophysical Research Communications. 287: 468-73. PMID 11554752 DOI: 10.1006/bbrc.2001.5617  1
2001 Ando S, Sarlis NJ, Krishnan J, Feng X, Refetoff S, Zhang MQ, Oldfield EH, Yen PM. Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance. Molecular Endocrinology (Baltimore, Md.). 15: 1529-38. PMID 11518802 DOI: 10.1210/mend.15.9.0687  1
2001 Montalvetti A, Bailey BN, Martin MB, Severin GW, Oldfield E, Docampo R. Bisphosphonates are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase. The Journal of Biological Chemistry. 276: 33930-7. PMID 11435429 DOI: 10.1074/jbc.M103950200  1
2001 Moreno B, Bailey BN, Luo S, Martin MB, Kuhlenschmidt M, Moreno SN, Docampo R, Oldfield E. (31)P NMR of apicomplexans and the effects of risedronate on Cryptosporidium parvum growth. Biochemical and Biophysical Research Communications. 284: 632-7. PMID 11396947 DOI: 10.1006/bbrc.2001.5009  1
2001 Martin MB, Grimley JS, Lewis JC, Heath HT, Bailey BN, Kendrick H, Yardley V, Caldera A, Lira R, Urbina JA, Moreno SN, Docampo R, Croft SL, Oldfield E. Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy. Journal of Medicinal Chemistry. 44: 909-16. PMID 11300872 DOI: 10.1021/jm0002578  1
2000 Szabo CM, Sanders LK, Le HC, Chien EY, Oldfield E. Expression of doubly labeled Saccharomyces cerevisiae iso-1 ferricytochrome c and (1)H, (13)C and (15)N chemical shift assignments by multidimensional NMR. Febs Letters. 482: 25-30. PMID 11018517 DOI: 10.1016/S0014-5793(00)02032-9  1
1999 Martin MB, Arnold W, Heath HT, Urbina JA, Oldfield E. Nitrogen-containing bisphosphonates as carbocation transition state analogs for isoprenoid biosynthesis. Biochemical and Biophysical Research Communications. 263: 754-8. PMID 10512752 DOI: 10.1006/bbrc.1999.1404  1
1996 de Dios AC, Oldfield E. Recent progress in understanding chemical shifts. Solid State Nuclear Magnetic Resonance. 6: 101-25. PMID 8784950 DOI: 10.1016/0926-2040(95)01207-9  1
1995 Jameson AK, Jameson CJ, de Dios AC, Oldfield E, Gerald RE, Turner GL. 129Xe Magic-angle spinning spectra of xenon in zeolite NaA direct observation of mixed clusters of co-adsorbed species Solid State Nuclear Magnetic Resonance. 4: 1-12. PMID 7894978 DOI: 10.1016/0926-2040(94)00028-B  1
1993 de Dios AC, Pearson JG, Oldfield E. Secondary and tertiary structural effects on protein NMR chemical shifts: an ab initio approach. Science (New York, N.Y.). 260: 1491-6. PMID 8502992  1
1993 Laws DD, de Dios AC, Oldfield E. NMR chemical shifts and structure refinement in proteins. Journal of Biomolecular Nmr. 3: 607-12. PMID 8219743 DOI: 10.1007/BF00174614  1
1975 Oldfield E, Allerhand A. Studies of individual carbon sites of hemoglobins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. The Journal of Biological Chemistry. 250: 6403-7. PMID 1158866  1
1975 Oldfield E, Allerhand A. Letter: Identification of tryptophan resonances in natural abundance carbon-13 nuclear magnetic resonance spectra of proteins. Application of partially relaxed Fourier transfrom spectroscopy. Journal of the American Chemical Society. 97: 221-4. PMID 1133334  1
1975 Oldfield E, Norton RS, Allerhand A. Studies of individual carbon sites of proteins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Strategies for assignments. The Journal of Biological Chemistry. 250: 6381-402. PMID 169240  1
1975 Oldfield E, Norton RS, Allerhand A. Studies of individual carbon sites of proteins in solution by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Relaxation behavior. The Journal of Biological Chemistry. 250: 6368-80. PMID 169239  1
1973 Allerhand A, Childers RF, Oldfield E. Natrual-abundance carbon-13 nuclear magnetic resonance studies in 20-mm sample tubes. Observation of numerous single-carbon resonances of hen egg-white lysozyme. Biochemistry. 12: 1335-41. PMID 4735301  1
1973 Allerhand A, Oldfield E. Determination of rotational mobilities of backbone and side-chain carbons of poly(gamma-benzyl L-glutamate) in the helical and random-coil states from measurements of carbon-13 relaxation times and nuclear Overhauser enhancements. Biochemistry. 12: 3428-33. PMID 4731187  1
1973 Allerhand A, Childers RF, Oldfield E. Carbon-13 Fourier transform NMR studies in 20 mm sample tubes: observation of individual carbon sites in proteins. Annals of the New York Academy of Sciences. 222: 764-77. PMID 4361880  1
1973 Oldfield E, Allerhand A. Cytochrome c: observation of numerous single-carbon sites of the reduced and oxidized species by means of natural-abundance 13C nuclear magnetic resonance spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 70: 3531-5. PMID 4357878  1
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