Samuel J. Danishefsky - Publications

Affiliations: 
Columbia University, New York, NY 
 Memorial Sloan-Kettering Cancer Center, Rockville Centre, NY, United States 
Area:
synthetic organic chemistry
Website:
http://www.mskcc.org/research/lab/samuel-danishefsky

291 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Li Y, Tran AH, Danishefsky SJ, Tan Z. Chemical biology of glycoproteins: From chemical synthesis to biological impact. Methods in Enzymology. 621: 213-229. PMID 31128780 DOI: 10.1016/bs.mie.2019.02.030  1
2018 Brailsford JA, Stockdill JL, Axelrod AJ, Peterson MT, Vadola PA, Johnston EV, Danishefsky SJ. Total Chemical Synthesis of Human Thyroid-Stimulating Hormone (hTSH) -Subunit: Application of Arginine-tagged Acetamidomethyl (Acm) Protecting Groups. Tetrahedron. 74: 1951-1956. PMID 30853725 DOI: 10.1016/j.tet.2018.02.067  1
2017 Rao TD, Fernández-Tejada A, Axelrod A, Rosales N, Yan X, Thapi S, Wang A, Park KJ, Nemieboka B, Xiang J, Lewis JS, Olvera N, Levine DA, Danishefsky SJ, Spriggs D. Antibodies Against Specific MUC16 Glycosylation Sites Inhibit Ovarian Cancer Growth. Acs Chemical Biology. PMID 28617578 DOI: 10.1021/acschembio.7b00305  1
2017 Levinson AM, McGee JH, Roberts AG, Creech G, Wang T, Peterson MT, Hendrickson RC, Verdine GL, Danishefsky SJ. Total Chemical Synthesis and Folding of All-L and All-D Variants of Oncogenic KRas(G12V). Journal of the American Chemical Society. PMID 28448128 DOI: 10.1021/jacs.7b02988  1
2017 Bonsignori M, Kreider EF, Fera D, Meyerhoff RR, Bradley T, Wiehe K, Alam SM, Aussedat B, Walkowicz WE, Hwang KK, Saunders KO, Zhang R, Gladden MA, Monroe A, Kumar A, ... ... Danishefsky SJ, et al. Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies. Science Translational Medicine. 9. PMID 28298420 DOI: 10.1126/scitranslmed.aai7514  1
2017 Saunders KO, Nicely NI, Wiehe K, Bonsignori M, Meyerhoff RR, Parks R, Walkowicz WE, Aussedat B, Wu NR, Cai F, Vohra Y, Park PK, Eaton A, Go EP, Sutherland LL, ... ... Danishefsky SJ, et al. Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates. Cell Reports. 18: 2175-2188. PMID 28249163 DOI: 10.1016/j.celrep.2017.02.003  1
2016 O'Cearbhaill RE, Ragupathi G, Zhu J, Wan Q, Mironov S, Yang G, Spassova MK, Iasonos A, Kravetz S, Ouerfelli O, Spriggs DR, Danishefsky SJ, Sabbatini PJ. A Phase I Study of Unimolecular Pentavalent (Globo-H-GM2-sTn-TF-Tn) Immunization of Patients with Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer in First Remission. Cancers. 8. PMID 27110823 DOI: 10.3390/cancers8040046  1
2015 Eller CH, Chao TY, Singarapu KK, Ouerfelli O, Yang G, Markley JL, Danishefsky SJ, Raines RT. Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1. Acs Central Science. 1: 181-190. PMID 26405690 DOI: 10.1021/acscentsci.5b00164  0.68
2015 Roberts AG, Johnston EV, Shieh JH, Sondey JP, Hendrickson RC, Moore MA, Danishefsky SJ. Fully Synthetic Granulocyte Colony-Stimulating Factor Enabled by Isonitrile-Mediated Coupling of Large, Side-Chain-Unprotected Peptides. Journal of the American Chemical Society. 137: 13167-75. PMID 26401918 DOI: 10.1021/jacs.5b08754  1
2015 Fernández-Tejada A, Haynes BF, Danishefsky SJ. Designing synthetic vaccines for HIV. Expert Review of Vaccines. 14: 815-31. PMID 25824661 DOI: 10.1586/14760584.2015.1027690  1
2015 Fernández-Tejada A, Brailsford J, Zhang Q, Shieh JH, Moore MA, Danishefsky SJ. Total synthesis of glycosylated proteins. Topics in Current Chemistry. 362: 1-26. PMID 25805144 DOI: 10.1007/128_2014_622  1
2015 Danishefsky SJ, Shue YK, Chang MN, Wong CH. Development of Globo-H cancer vaccine. Accounts of Chemical Research. 48: 643-52. PMID 25665650 DOI: 10.1021/ar5004187  1
2014 Hartung J, J D Wright B, Danishefsky SJ. Studies toward the total synthesis of pluraflavin A. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 8731-6. PMID 24919792 DOI: 10.1002/chem.201402254  1
2014 Townsend SD, Ross AG, Liu K, Danishefsky SJ. Stereospecific cis- and trans-ring fusions arising from common intermediates. Proceedings of the National Academy of Sciences of the United States of America. 111: 7931-5. PMID 24843125 DOI: 10.1073/pnas.1407613111  1
2014 Fernández-Tejada A, Vadola PA, Danishefsky SJ. Chemical synthesis of the β-subunit of human luteinizing (hLH) and chorionic gonadotropin (hCG) glycoprotein hormones. Journal of the American Chemical Society. 136: 8450-8. PMID 24806200 DOI: 10.1021/ja503545r  1
2014 Creech GS, Paresi C, Li YM, Danishefsky SJ. Chemical synthesis of the ATAD2 bromodomain. Proceedings of the National Academy of Sciences of the United States of America. 111: 2891-6. PMID 24516155 DOI: 10.1073/pnas.1400556111  1
2014 Zhang Q, Johnston EV, Shieh JH, Moore MA, Danishefsky SJ. Synthesis of granulocyte-macrophage colony-stimulating factor as homogeneous glycoforms and early comparisons with yeast cell-derived material. Proceedings of the National Academy of Sciences of the United States of America. 111: 2885-90. PMID 24516138 DOI: 10.1073/pnas.1400140111  1
2014 Pham HV, Paton RS, Ross AG, Danishefsky SJ, Houk KN. Intramolecular Diels-Alder reactions of cycloalkenones: stereoselectivity, Lewis acid acceleration, and halogen substituent effects. Journal of the American Chemical Society. 136: 2397-403. PMID 24410341 DOI: 10.1021/ja410220w  1
2014 Fernández-Tejada A, Danishefsky SJ. Development of cancer vaccines from fully synthetic mucin-based glycopeptide antigens. A vision on mucins from the bioorganic chemistry perspective Carbohydrate Chemistry. 40: 533-563. DOI: 10.1039/9781849739986-00533  1
2013 Wang P, Dong S, Shieh JH, Peguero E, Hendrickson R, Moore MA, Danishefsky SJ. Erythropoietin derived by chemical synthesis. Science (New York, N.Y.). 342: 1357-60. PMID 24337294 DOI: 10.1126/science.1245095  1
2013 Alam SM, Dennison SM, Aussedat B, Vohra Y, Park PK, Fernández-Tejada A, Stewart S, Jaeger FH, Anasti K, Blinn JH, Kepler TB, Bonsignori M, Liao HX, Sodroski JG, Danishefsky SJ, et al. Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proceedings of the National Academy of Sciences of the United States of America. 110: 18214-9. PMID 24145434 DOI: 10.1073/pnas.1317855110  1
2013 Wilson RM, Danishefsky SJ. A vision for vaccines built from fully synthetic tumor-associated antigens: from the laboratory to the clinic. Journal of the American Chemical Society. 135: 14462-72. PMID 23944352 DOI: 10.1021/ja405932r  1
2013 Aussedat B, Vohra Y, Park PK, Fernández-Tejada A, Alam SM, Dennison SM, Jaeger FH, Anasti K, Stewart S, Blinn JH, Liao HX, Sodroski JG, Haynes BF, Danishefsky SJ. Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccines. Journal of the American Chemical Society. 135: 13113-20. PMID 23915436 DOI: 10.1021/ja405990z  1
2013 Wang T, Danishefsky SJ. Solid-phase peptide synthesis and solid-phase fragment coupling mediated by isonitriles. Proceedings of the National Academy of Sciences of the United States of America. 110: 11708-13. PMID 23821753 DOI: 10.1073/pnas.1310431110  1
2013 Peng F, Grote RE, Wilson RM, Danishefsky SJ. Pattern recognition analysis in complex molecule synthesis and the preparation of iso-Diels-Alder motifs. Proceedings of the National Academy of Sciences of the United States of America. 110: 10904-9. PMID 23784777 DOI: 10.1073/pnas.1309795110  1
2013 Wilson RM, Dong S, Wang P, Danishefsky SJ. The winding pathway to erythropoietin along the chemistry-biology frontier: a success at last. Angewandte Chemie (International Ed. in English). 52: 7646-65. PMID 23775885 DOI: 10.1002/anie.201301666  1
2013 Walczak MA, Hayashida J, Danishefsky SJ. Building biologics by chemical synthesis: practical preparation of di- and triantennary N-linked glycoconjugates. Journal of the American Chemical Society. 135: 4700-3. PMID 23461434 DOI: 10.1021/ja401385v  1
2013 Ross AG, Townsend SD, Danishefsky SJ. Halocycloalkenones as Diels-Alder dienophiles. Applications to generating useful structural patterns. The Journal of Organic Chemistry. 78: 204-10. PMID 23151095 DOI: 10.1021/jo302230m  1
2012 Peng F, Dai M, Angeles AR, Danishefsky SJ. Permuting Diels-Alder and Robinson Annulation Stereopatterns. Chemical Science (Royal Society of Chemistry : 2010). 3: 3076-3080. PMID 23139855 DOI: 10.1039/C2SC20868G  1
2012 Peng F, Danishefsky SJ. Total synthesis of (±)-maoecrystal V. Journal of the American Chemical Society. 134: 18860-7. PMID 23126440 DOI: 10.1021/ja309905j  1
2012 Li J, Dong S, Townsend SD, Dean T, Gardella TJ, Danishefsky SJ. Chemistry as an expanding resource in protein science: fully synthetic and fully active human parathyroid hormone-related protein (1-141). Angewandte Chemie (International Ed. in English). 51: 12263-7. PMID 23124999 DOI: 10.1002/anie.201207603  1
2012 Wang P, Dong S, Brailsford JA, Iyer K, Townsend SD, Zhang Q, Hendrickson RC, Shieh J, Moore MA, Danishefsky SJ. At last: erythropoietin as a single glycoform. Angewandte Chemie (International Ed. in English). 51: 11576-84. PMID 23012228 DOI: 10.1002/anie.201206090  1
2012 Wang P, Aussedat B, Vohra Y, Danishefsky SJ. An advance in the chemical synthesis of homogeneous N-linked glycopolypeptides by convergent aspartylation. Angewandte Chemie (International Ed. in English). 51: 11571-5. PMID 23011954 DOI: 10.1002/anie.201205038  1
2012 Walczak MA, Danishefsky SJ. Solving the convergence problem in the synthesis of triantennary N-glycan relevant to prostate-specific membrane antigen (PSMA). Journal of the American Chemical Society. 134: 16430-3. PMID 22954207 DOI: 10.1021/ja307628w  1
2012 Ross AG, Li X, Danishefsky SJ. Intramolecular Diels-Alder reactions of cycloalkenones: translation of high endo selectivity to trans junctions. Journal of the American Chemical Society. 134: 16080-4. PMID 22950514 DOI: 10.1021/ja307708q  1
2012 Dong S, Shang S, Li J, Tan Z, Dean T, Maeda A, Gardella TJ, Danishefsky SJ. Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues. Journal of the American Chemical Society. 134: 15122-9. PMID 22891619 DOI: 10.1021/ja306637u  1
2012 Wang T, Danishefsky SJ. Revisiting oxytocin through the medium of isonitriles. Journal of the American Chemical Society. 134: 13244-7. PMID 22830449 DOI: 10.1021/ja3063452  1
2012 Townsend SD, Wu X, Danishefsky SJ. Enhancing the scope of the Diels-Alder reaction through isonitrile chemistry: emergence of a new class of acyl-activated dienophiles. Journal of the American Chemical Society. 134: 10659-63. PMID 22708980 DOI: 10.1021/ja303876e  1
2012 Brailsford JA, Danishefsky SJ. Probing the stability of nonglycosylated wild-type erythropoietin protein via reiterative alanine ligations. Proceedings of the National Academy of Sciences of the United States of America. 109: 7196-201. PMID 22499784 DOI: 10.1073/pnas.1202762109  1
2012 Wilson RM, Stockdill JL, Wu X, Li X, Vadola PA, Park PK, Wang P, Danishefsky SJ. A fascinating journey into history: exploration of the world of isonitriles en route to complex amides. Angewandte Chemie (International Ed. in English). 51: 2834-48. PMID 22368033 DOI: 10.1002/anie.201106628  1
2012 Townsend SD, Tan Z, Dong S, Shang S, Brailsford JA, Danishefsky SJ. Advances in proline ligation. Journal of the American Chemical Society. 134: 3912-6. PMID 22332757 DOI: 10.1021/ja212182q  1
2012 Aussedat B, Fasching B, Johnston E, Sane N, Nagorny P, Danishefsky SJ. Total synthesis of the α-subunit of human glycoprotein hormones: toward fully synthetic homogeneous human follicle-stimulating hormone. Journal of the American Chemical Society. 134: 3532-41. PMID 22280541 DOI: 10.1021/ja2111459  1
2012 Wu X, Stockdill JL, Park PK, Danishefsky SJ. Expanding the limits of isonitrile-mediated amidations: on the remarkable stereosubtleties of macrolactam formation from synthetic seco-cyclosporins. Journal of the American Chemical Society. 134: 2378-84. PMID 22280518 DOI: 10.1021/ja2103372  1
2012 Nagorny P, Sane N, Fasching B, Aussedat B, Danishefsky SJ. Probing the frontiers of glycoprotein synthesis: the fully elaborated β-subunit of the human follicle-stimulating hormone. Angewandte Chemie (International Ed. in English). 51: 975-9. PMID 22162182 DOI: 10.1002/anie.201107482  1
2012 Konner J, Grisham RN, Park J, O'Connor OA, Cropp G, Johnson R, Hannah AL, Hensley ML, Sabbatini P, Mironov S, Miranov S, Danishefsky S, Hyman D, Spriggs DR, Dupont J, et al. Phase I clinical, pharmacokinetic, and pharmacodynamic study of KOS-862 (Epothilone D) in patients with advanced solid tumors and lymphoma. Investigational New Drugs. 30: 2294-302. PMID 22072399 DOI: 10.1007/s10637-011-9765-7  1
2012 Ross AG, Li X, Danishefsky SJ. Preparation of cyclobutenone Organic Syntheses. 89: 491-500. DOI: 10.15227/orgsyn.089.0491  1
2012 Liu L, Danishefsky S, Crich D. Chemical Synthesis of Proteins Organic Chemistry - Breakthroughs and Perspectives. 221-245. DOI: 10.1002/9783527664801.ch6  1
2012 Yu B, Wang LX, Danishefsky S, Crich D. Carbohydrate Synthesis towards Glycobiology Organic Chemistry - Breakthroughs and Perspectives. 181-219. DOI: 10.1002/9783527664801.ch5  1
2011 Dong S, Shang S, Tan Z, Danishefsky SJ. Toward Homogeneous Erythropoietin: Application of Metal Free Dethiylation in the Chemical Synthesis of the Ala79-Arg166 Glycopeptide Domain. Israel Journal of Chemistry. 51: 968-976. PMID 23585694 DOI: 10.1002/ijch.201100077  1
2011 Wang Z, Dai M, Park PK, Danishefsky SJ. Synthetic studies toward (+)-cortistatin A. Tetrahedron. 67: 10249-10260. PMID 22879684 DOI: 10.1016/j.tet.2011.10.026  1
2011 Paton RS, Kim S, Ross AG, Danishefsky SJ, Houk KN. Experimental Diels-Alder reactivities of cycloalkenones and cyclic dienes explained through transition-state distortion energies. Angewandte Chemie (International Ed. in English). 50: 10366-8. PMID 21910195 DOI: 10.1002/anie.201103998  1
2011 Chou TC, Dong H, Zhang X, Lei X, Hartung J, Zhang Y, Lee JH, Wilson RM, Danishefsky SJ. Multifaceted cytoprotection by synthetic polyacetylenes inspired by the ginseng-derived natural product, panaxytriol. Proceedings of the National Academy of Sciences of the United States of America. 108: 14336-41. PMID 21844359 DOI: 10.1073/pnas.1111332108  1
2011 Peng F, Grote RE, Danishefsky SJ. Further Expansion of the trans-Diels-Alder Paradigm: Reductive Alkylation of α-Cyanoketones. Tetrahedron Letters. 52: 3957-3959. PMID 21808427 DOI: 10.1016/j.tetlet.2011.05.110  1
2011 Lecomte N, Njardarson JT, Nagorny P, Yang G, Downey R, Ouerfelli O, Moore MA, Danishefsky SJ. Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin. Proceedings of the National Academy of Sciences of the United States of America. 108: 15074-8. PMID 21808037 DOI: 10.1073/pnas.1015247108  1
2011 Shang S, Tan Z, Dong S, Danishefsky SJ. An advance in proline ligation. Journal of the American Chemical Society. 133: 10784-6. PMID 21696220 DOI: 10.1021/ja204277b  1
2011 Wu X, Park PK, Danishefsky SJ. On the synthesis of conformationally modified peptides through isonitrile chemistry: implications for dealing with polypeptide aggregation. Journal of the American Chemical Society. 133: 7700-3. PMID 21539308 DOI: 10.1021/ja2023898  1
2011 Peng F, Danishefsky SJ. Toward the total synthesis of maoecrystal V: an intramolecular Diels-Alder route to the maoecrystal V pentacyclic core with the appropriate relative stereochemistry. Tetrahedron Letters. 52: 2104-2106. PMID 21516211 DOI: 10.1016/j.tetlet.2010.11.029  1
2011 Shang S, Tan Z, Danishefsky SJ. Application of the logic of cysteine-free native chemical ligation to the synthesis of Human Parathyroid Hormone (hPTH). Proceedings of the National Academy of Sciences of the United States of America. 108: 5986-9. PMID 21444787 DOI: 10.1073/pnas.1103118108  1
2011 Tan Z, Shang S, Danishefsky SJ. Rational development of a strategy for modifying the aggregatibility of proteins. Proceedings of the National Academy of Sciences of the United States of America. 108: 4297-302. PMID 21368182 DOI: 10.1073/pnas.1100195108  1
2011 Wang P, Li X, Zhu J, Chen J, Yuan Y, Wu X, Danishefsky SJ. Encouraging progress in the ω-aspartylation of complex oligosaccharides as a general route to β-N-linked glycopolypeptides. Journal of the American Chemical Society. 133: 1597-602. PMID 21207981 DOI: 10.1021/ja110115a  1
2011 Zhang Y, Lee JH, Danishefsky SJ. Antarafacial mediation of oxygen delivery by a phenylsulfinyl group in the epoxidation of proximal double bonds: intramolecular trapping of an early Pummerer intermediate with stereoelectronic control. Journal of the American Chemical Society. 133: 752-5. PMID 21182300 DOI: 10.1021/ja1107707  1
2010 Tan Z, Shang S, Danishefsky SJ. Insights into the finer issues of native chemical ligation: an approach to cascade ligations. Angewandte Chemie (International Ed. in English). 49: 9500-3. PMID 21053233 DOI: 10.1002/anie.201005513  1
2010 Wang P, Danishefsky SJ. Promising general solution to the problem of ligating peptides and glycopeptides. Journal of the American Chemical Society. 132: 17045-51. PMID 21049949 DOI: 10.1021/ja1084628  1
2010 Lee JH, Zhang Y, Danishefsky SJ. A straightforward route to functionalized trans-Diels-Alder motifs. Journal of the American Chemical Society. 132: 14330-3. PMID 20863105 DOI: 10.1021/ja1073855  1
2010 Lee JH, Danishefsky SJ. Diels-Alder routes to angularly halogenated cis-fused bicyclic ketones: Readily accessible cyclynone intermediates. Tetrahedron Letters. 51: 4653-4654. PMID 20835369 DOI: 10.1016/j.tetlet.2010.06.135  1
2010 Chen J, Wang P, Zhu J, Wan Q, Danishefsky SJ. A program for ligation at threonine sites: application to the controlled total synthesis of glycopeptides. Tetrahedron. 66: 2277-2283. PMID 20798898 DOI: 10.1016/j.tet.2010.01.067  1
2010 Kim WH, Lee JH, Aussedat B, Danishefsky SJ. A Diels-Alder Route to Angularly Functionalized Bicyclic Structures. Tetrahedron. 66: 6391-6398. PMID 20717474 DOI: 10.1016/j.tet.2010.04.094  1
2010 Trzupek JD, Li C, Chan C, Crowley BM, Heimann AC, Danishefsky SJ. Lessons from the Total Synthesis of (±) Phalarine: Insights Into the Mechanism of the Pictet-Spengler Reaction. Pure and Applied Chemistry. Chimie Pure Et Appliquee. 82: 1735-1748. PMID 20711493  1
2010 Li X, Danishefsky SJ. Cyclobutenone as a highly reactive dienophile: expanding upon Diels-Alder paradigms. Journal of the American Chemical Society. 132: 11004-5. PMID 20698657 DOI: 10.1021/ja1056888  1
2010 Nagorny P, Krauss I, Njardarson JT, Perez L, Gaul C, Yang G, Ouerfelli O, Danishefsky SJ. Confirmation of the Structures of Synthetic Derivatives of Migrastatin in the Light of Recently Disclosed Crystallographically Based Claims. Tetrahedron Letters. 51: 3873-3875. PMID 20676392 DOI: 10.1016/j.tetlet.2010.05.056  1
2010 Wilson RM, Danishefsky SJ. On the reach of chemical synthesis: creation of a mini-pipeline from an academic laboratory. Angewandte Chemie (International Ed. in English). 49: 6032-56. PMID 20661969 DOI: 10.1002/anie.201000775  1
2010 Yuan Y, Chen J, Wan Q, Wilson RM, Danishefsky SJ. Toward fully synthetic, homogeneous glycoproteins: advances in chemical ligation. Biopolymers. 94: 373-84. PMID 20593459 DOI: 10.1002/bip.21374  1
2010 Paton RS, Mackey JL, Kim WH, Lee JH, Danishefsky SJ, Houk KN. Origins of stereoselectivity in the trans Diels-Alder paradigm. Journal of the American Chemical Society. 132: 9335-40. PMID 20557046 DOI: 10.1021/ja1009162  1
2010 Zhang Y, Danishefsky SJ. Total synthesis of (+/-)-aplykurodinone-1: traceless stereochemical guidance. Journal of the American Chemical Society. 132: 9567-9. PMID 20513158 DOI: 10.1021/ja1035495  1
2010 Trzupek JD, Lee D, Crowley BM, Marathias VM, Danishefsky SJ. Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan. Journal of the American Chemical Society. 132: 8506-12. PMID 20509657 DOI: 10.1021/ja1030968  1
2010 Danishefsky S. On the potential of natural products in the discovery of pharma leads: A case for reassessment Natural Product Reports. 27: 1114-1116. PMID 20383353 DOI: 10.1039/c003211p  1
2010 Lee D, Danishefsky SJ. Cascade resulting in the reductive ethynylation of aldehydes: dissection of its components. Journal of the American Chemical Society. 132: 4427-30. PMID 20201522 DOI: 10.1021/ja910825g  1
2010 Wu X, Stockdill JL, Wang P, Danishefsky SJ. Total synthesis of cyclosporine: access to N-methylated peptides via isonitrile coupling reactions. Journal of the American Chemical Society. 132: 4098-100. PMID 20199071 DOI: 10.1021/ja100517v  1
2010 Lee JH, Kim WH, Danishefsky SJ. An Ionic Diels-Alder Route to cis-Fused Octalins Containing an All-Carbon Quaternary Stereocenter in an Angular Position. Tetrahedron Letters. 51: 1252. PMID 20174450 DOI: 10.1016/j.tetlet.2009.12.127  1
2010 Oskarsson T, Nagorny P, Krauss IJ, Perez L, Mandal M, Yang G, Ouerfelli O, Xiao D, Moore MA, Massagué J, Danishefsky SJ. Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog. Journal of the American Chemical Society. 132: 3224-8. PMID 20155906 DOI: 10.1021/ja9101503  1
2010 Trzupek JD, Li C, Chan C, Crowley BM, Heimann AC, Danishefsky SJ. Lessons from the total synthesis of (±)-phalarine: Insights into the mechanism of the Pictet-Spengler reaction Pure and Applied Chemistry. 82: 1735-1748. DOI: 10.1351/PAC-CON-09-11-14  1
2010 Tsukano C, Siegel DR, Danishefsky SJ. Total syntheses of polycyclic polyp renylated acylphloroglucinols Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 68: 592-600.  1
2009 Zhu J, Wu X, Danishefsky SJ. On the Preparation of Enantiomerically Pure Isonitriles from Amino Acid Esters and Peptides. Tetrahedron Letters. 50: 577-579. PMID 21869850 DOI: 10.1016/j.tetlet.2008.11.069  1
2009 Lee D, Danishefsky SJ. "Biologic" level structures through chemistry: A total synthesis of a unimolecular pentavalent MUCI glycopeptide construct. Tetrahedron Letters. 50: 2167-2170. PMID 21423786  0.6
2009 Zhu J, Wan Q, Yang G, Ouerfelli O, Danishefsky SJ. Synthesis of Human Cancer Associated Globo-H (MBr1) Glycosylamino Acid: Some Mechanistic and Conformational Reinvestigations. Heterocycles. 79: 441-449. PMID 21423783 DOI: 10.3987/COM-08-S(D)82  1
2009 Lee JH, Kim WH, Danishefsky SJ. Syntheses of Isomerically Pure Reference Octalins and Hydrindanes. Tetrahedron Letters. 50: 5482-5484. PMID 20711484 DOI: 10.1016/j.tetlet.2009.07.068  1
2009 Yuan Y, Chen J, Wan Q, Tan Z, Chen G, Kan C, Danishefsky SJ. Toward homogeneous erythropoietin: fine tuning of the C-terminal acyl donor in the chemical synthesis of the Cys29-Gly77 glycopeptide domain. Journal of the American Chemical Society. 131: 5432-7. PMID 20560636 DOI: 10.1021/ja808705v  1
2009 Peng F, Yu M, Danishefsky SJ. Synthetic Studies towards Maoecrystal V. Tetrahedron Letters. 50: 6586. PMID 20174449 DOI: 10.1016/j.tetlet.2009.09.050  1
2009 Kan C, Danishefsky SJ. Recent Departures in the Synthesis of Peptides and Glycopeptides. Tetrahedron. 65: 9047-9065. PMID 20161377 DOI: 10.1016/j.tet.2009.09.032  1
2009 Wu X, Li X, Danishefsky SJ. Thio-mediated two-component coupling reaction of carboxylic acids and isonitriles under mild conditions. Tetrahedron Letters. 50: 1523-1525. PMID 20161329 DOI: 10.1016/j.tetlet.2009.01.046  1
2009 Yuan Y, Zhu J, Li X, Wu X, Danishefsky SJ. Preparation and reactions of N-thioformyl peptides from amino thioacids and isonitriles. Tetrahedron Letters. 50: 2329-2333. PMID 20161291 DOI: 10.1016/j.tetlet.2009.02.205  1
2009 Wu X, Yuan Y, Li X, Danishefsky SJ. Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry. Tetrahedron Letters. 50: 4666-4669. PMID 20161157 DOI: 10.1016/j.tetlet.2009.06.005  1
2009 Stockdill JL, Wu X, Danishefsky SJ. Coupling reactions of hindered isonitriles and hindered alkyl thioacids: Mechanistic studies. Tetrahedron Letters. 50: 5152-5155. PMID 20160954 DOI: 10.1016/j.tetlet.2009.06.129  1
2009 Kim WH, Angeles AR, Lee JH, Danishefsky SJ. Concise Synthesis of the Xenibellols Core. Tetrahedron Letters. 50: 6440-6441. PMID 20160940 DOI: 10.1016/j.tetlet.2009.08.131  1
2009 Rao Y, Li X, Nagorny P, Hayashida J, Danishefsky SJ. A Simple Method for the Conversion of Carboxylic Acids into Thioacids with Lawesson's Reagent. Tetrahedron Letters. 50: 6684-6686. PMID 20160926 DOI: 10.1016/j.tetlet.2009.09.080  1
2009 Zhu J, Wan Q, Danishefsky SJ. Synthesis of Biotinylated Tumor-Associated Carbohydrate Antigens for Immunological Studies. Tetrahedron Letters. 50: 712-714. PMID 20157341 DOI: 10.1016/j.tetlet.2008.11.113  1
2009 Wang P, Zhu J, Yuan Y, Danishefsky SJ. Total synthesis of the 2,6-sialylated immunoglobulin G glycopeptide fragment in homogeneous form. Journal of the American Chemical Society. 131: 16669-71. PMID 19886622 DOI: 10.1021/ja907136d  1
2009 Jeon I, Iyer K, Danishefsky SJ. A practical total synthesis of globo-H for use in anticancer vaccines. The Journal of Organic Chemistry. 74: 8452-5. PMID 19874068 DOI: 10.1021/jo901682p  1
2009 Zhu J, Warren JD, Danishefsky SJ. Synthetic carbohydrate-based anticancer vaccines: the Memorial Sloan-Kettering experience. Expert Review of Vaccines. 8: 1399-413. PMID 19803761 DOI: 10.1586/erv.09.95  1
2009 Jeon I, Lee D, Krauss IJ, Danishefsky SJ. A new model for the presentation of tumor-associated antigens and the quest for an anticancer vaccine: a solution to the synthesis challenge via ring-closing metathesis. Journal of the American Chemical Society. 131: 14337-44. PMID 19746915 DOI: 10.1021/ja9052625  1
2009 Wang Z, Min SJ, Danishefsky SJ. Total synthesis and structural revision of (+/-)-tricholomalides A and B. Journal of the American Chemical Society. 131: 10848-9. PMID 19722666 DOI: 10.1021/ja9049433  1
2009 Rao Y, Li X, Danishefsky SJ. Thio FCMA intermediates as strong acyl donors: a general solution to the formation of complex amide bonds. Journal of the American Chemical Society. 131: 12924-6. PMID 19697932 DOI: 10.1021/ja906005j  1
2009 Kim WH, Lee JH, Danishefsky SJ. Improved dienophilicity of nitrocycloalkenes: prospects for the development of a trans-Diels-Alder paradigm. Journal of the American Chemical Society. 131: 12576-8. PMID 19685875 DOI: 10.1021/ja9058926  1
2009 Hayden AE, DeChancie J, George AH, Dai M, Yu M, Danishefsky SJ, Houk KN. Origins of the regioselectivities in the Diels-Alder reactions of vinylindenes with 1,4-quinone monoketal and acrolein dienophiles. The Journal of Organic Chemistry. 74: 6770-6. PMID 19663431 DOI: 10.1021/jo901473h  1
2009 Nagorny P, Kim WH, Wan Q, Lee D, Danishefsky SJ. On the emerging role of chemistry in the fashioning of biologics: synthesis of a bidomainal fucosyl GM1-based vaccine for the treatment of small cell lung cancer. The Journal of Organic Chemistry. 74: 5157-62. PMID 19555091 DOI: 10.1021/jo900918m  1
2009 Zhu J, Wan Q, Lee D, Yang G, Spassova MK, Ouerfelli O, Ragupathi G, Damani P, Livingston PO, Danishefsky SJ. From synthesis to biologics: preclinical data on a chemistry derived anticancer vaccine. Journal of the American Chemical Society. 131: 9298-303. PMID 19518111 DOI: 10.1021/ja901415s  1
2009 Nagorny P, Fasching B, Li X, Chen G, Aussedat B, Danishefsky SJ. Toward fully synthetic homogeneous beta-human follicle-stimulating hormone (beta-hFSH) with a biantennary N-linked dodecasaccharide. synthesis of beta-hFSH with chitobiose units at the natural linkage sites. Journal of the American Chemical Society. 131: 5792-9. PMID 19341309 DOI: 10.1021/ja809554x  1
2009 Tan Z, Shang S, Halkina T, Yuan Y, Danishefsky SJ. Toward homogeneous erythropoietin: non-NCL-based chemical synthesis of the Gln78-Arg166 glycopeptide domain. Journal of the American Chemical Society. 131: 5424-31. PMID 19334683 DOI: 10.1021/ja808704m  1
2009 Kan C, Trzupek JD, Wu B, Wan Q, Chen G, Tan Z, Yuan Y, Danishefsky SJ. Toward homogeneous erythropoietin: chemical synthesis of the Ala1-Gly28 glycopeptide domain by "alanine" ligation. Journal of the American Chemical Society. 131: 5438-43. PMID 19334679 DOI: 10.1021/ja808707w  1
2009 Lee LS, Stephenson KK, Fahey JW, Parsons TL, Lietman PS, Andrade AS, Lei X, Yun H, Soon GH, Shen P, Danishefsky S, Flexner C. Induction of chemoprotective phase 2 enzymes by ginseng and its components. Planta Medica. 75: 1129-33. PMID 19326326 DOI: 10.1055/s-0029-1185508  1
2009 Zhu J, Wan Q, Ragupathi G, George CM, Livingston PO, Danishefsky SJ. Biologics through chemistry: total synthesis of a proposed dual-acting vaccine targeting ovarian cancer by orchestration of oligosaccharide and polypeptide domains. Journal of the American Chemical Society. 131: 4151-8. PMID 19253940 DOI: 10.1021/ja810147j  1
2009 Dai M, Danishefsky SJ. An oxidative dearomatization cyclization model for cortistatin A Heterocycles. 77: 157-161. DOI: 10.3987/COM-08-S(F)6  1
2009 Lee D, Danishefsky SJ. 'Biologic' level structures through chemistry: a total synthesis of a unimolecular pentavalent MUCI glycopeptide construct Tetrahedron Letters. 50: 2167-2170. DOI: 10.1016/j.tetlet.2009.02.138  1
2008 Lei X, Danishefsky SJ. Efficient Synthesis of a Novel Resorcyclide as Anticancer Agent Based on Hsp90 Inhibition. Advanced Synthesis & Catalysis. 350: 1677-1681. PMID 21442009  0.76
2008 Ng F, Yun H, Lei X, Danishefsky SJ, Fahey J, Stephenson K, Flexner C, Lee L. (3R, 9R, 10R)-Panaxytriol: A molecular-based nutraceutical with possible application to cancer prevention and treatment. Tetrahedron Letters. 49: 7178-7179. PMID 20011028 DOI: 10.1016/j.tetlet.2008.09.169  1
2008 Dai M, Wang Z, Danishefsky SJ. A novel α,β-unsaturated nitrone-aryne [3+2] cycloaddition and its application in the synthesis of the cortistatin core. Tetrahedron Letters. 49: 6613-6616. PMID 19924220 DOI: 10.1016/j.tetlet.2008.09.019  1
2008 Dai M, Danishefsky SJ. A concise synthesis of the cortistatin core. Tetrahedron Letters. 49: 6610-6612. PMID 19924219 DOI: 10.1016/j.tetlet.2008.09.018  1
2008 Lei X, Dai M, Hua Z, Danishefsky SJ. Biomimetic total synthesis of tricycloillicinone and mechanistic studies toward the rearrangement of prenyl phenyl ethers. Tetrahedron Letters. 49: 6383-6385. PMID 19890380 DOI: 10.1016/j.tetlet.2008.07.184  1
2008 Polara A, Cook SP, Danishefsky SJ. Multiple chirality transfers in the enantioselective synthesis of 11-O-debenzoyltashironin. Chiroptical analysis of the key cascade. Tetrahedron Letters. 49: 5906-5908. PMID 19812682 DOI: 10.1016/j.tetlet.2008.07.139  1
2008 Min SJ, Danishefsky SJ. An Approach to the Synthesis of Tricholomalide A: An Effective Means for Achieving Homo-Robinson Annulation. Tetrahedron Letters. 49: 3496-3499. PMID 19461989 DOI: 10.1016/j.tetlet.2008.03.101  1
2008 Wright BJ, Hartung J, Peng F, Van de Water R, Liu H, Tan QH, Chou TC, Danishefsky SJ. Synthesis of pluraflavin A "aglycone". Journal of the American Chemical Society. 130: 16786-90. PMID 19049469 DOI: 10.1021/ja805936v  1
2008 Dai M, Krauss IJ, Danishefsky SJ. Total synthesis of spirotenuipesines A and B. The Journal of Organic Chemistry. 73: 9576-83. PMID 18973385 DOI: 10.1021/jo8016814  1
2008 Wan Q, Chen J, Yuan Y, Danishefsky SJ. Oxo-ester mediated native chemical ligation: concept and applications. Journal of the American Chemical Society. 130: 15814-6. PMID 18855357 DOI: 10.1021/ja804993y  1
2008 Joyce JG, Krauss IJ, Song HC, Opalka DW, Grimm KM, Nahas DD, Esser MT, Hrin R, Feng M, Dudkin VY, Chastain M, Shiver JW, Danishefsky SJ. An oligosaccharide-based HIV-1 2G12 mimotope vaccine induces carbohydrate-specific antibodies that fail to neutralize HIV-1 virions. Proceedings of the National Academy of Sciences of the United States of America. 105: 15684-9. PMID 18838688 DOI: 10.1073/pnas.0807837105  1
2008 Chen J, Wan Q, Yuan Y, Zhu J, Danishefsky SJ. Native chemical ligation at valine: a contribution to peptide and glycopeptide synthesis. Angewandte Chemie (International Ed. in English). 47: 8521-4. PMID 18833563 DOI: 10.1002/anie.200803523  1
2008 Li X, Danishefsky SJ. Noncatalytic reaction of isonitriles and carboxylic acids en route to amide-type linkages. Nature Protocols. 3: 1666-70. PMID 18833204 DOI: 10.1038/nprot.2008.153  1
2008 Dudkin VY, Miller JS, Dudkina AS, Antczak C, Scheinberg DA, Danishefsky SJ. Toward a prostate specific antigen-based prostate cancer diagnostic assay: preparation of keyhole limpet hemocyanin-conjugated normal and transformed prostate specific antigen fragments. Journal of the American Chemical Society. 130: 13598-607. PMID 18798614 DOI: 10.1021/ja8028137  1
2008 Angeles AR, Waters SP, Danishefsky SJ. Total syntheses of (+)- and (-)-peribysin E. Journal of the American Chemical Society. 130: 13765-70. PMID 18783227 DOI: 10.1021/ja8048207  1
2008 Li X, Yuan Y, Kan C, Danishefsky SJ. Addressing mechanistic issues in the coupling of isonitriles and carboxylic acids: potential routes to peptidic constructs. Journal of the American Chemical Society. 130: 13225-7. PMID 18783225 DOI: 10.1021/ja804709s  1
2008 Li X, Yuan Y, Berkowitz WF, Todaro LJ, Danishefsky SJ. On the two-component microwave-mediated reaction of isonitriles with carboxylic acids: regarding alleged formimidate carboxylate mixed anhydrides. Journal of the American Chemical Society. 130: 13222-4. PMID 18783224 DOI: 10.1021/ja8047078  1
2008 Chou TC, Zhang X, Zhong ZY, Li Y, Feng L, Eng S, Myles DR, Johnson R, Wu N, Yin YI, Wilson RM, Danishefsky SJ. Therapeutic effect against human xenograft tumors in nude mice by the third generation microtubule stabilizing epothilones. Proceedings of the National Academy of Sciences of the United States of America. 105: 13157-62. PMID 18755900 DOI: 10.1073/pnas.0804773105  1
2008 Jones GO, Li X, Hayden AE, Houk KN, Danishefsky SJ. The coupling of isonitriles and carboxylic acids occurring by sequential concerted rearrangement mechanisms. Organic Letters. 10: 4093-6. PMID 18707109 DOI: 10.1021/ol8016287  1
2008 Li X, Danishefsky SJ. New chemistry with old functional groups: on the reaction of isonitriles with carboxylic acids--a route to various amide types. Journal of the American Chemical Society. 130: 5446-8. PMID 18370392 DOI: 10.1021/ja800612r  1
2008 Wright BJ, Chan C, Danishefsky SJ. Synthesis and cytotoxic evaluation of some cribrostatin-ecteinascidin analogues. Journal of Natural Products. 71: 409-14. PMID 18278868 DOI: 10.1021/np800022x  1
2008 Yu M, Danishefsky SJ. A direct route to fluostatin C by a fascinating Diels-Alder reaction. Journal of the American Chemical Society. 130: 2783-5. PMID 18254631 DOI: 10.1021/ja7113757  1
2007 Wan Q, Danishefsky SJ. Free-radical-based, specific desulfurization of cysteine: a powerful advance in the synthesis of polypeptides and glycopolypeptides. Angewandte Chemie (International Ed. in English). 46: 9248-52. PMID 18046687 DOI: 10.1002/anie.200704195  1
2007 Tsukano C, Siegel DR, Danishefsky SJ. Differentiation of nonconventional "carbanions"-the total synthesis of nemorosone and clusianone. Angewandte Chemie (International Ed. in English). 46: 8840-4. PMID 17935090 DOI: 10.1002/anie.200703886  1
2007 Maloney DJ, Danishefsky SJ. Conformational locking through allylic strain as a device for stereocontrol--total synthesis of grandisine A. Angewandte Chemie (International Ed. in English). 46: 7789-92. PMID 17876796 DOI: 10.1002/anie.200703245  1
2007 Chen G, Wan Q, Tan Z, Kan C, Hua Z, Ranganathan K, Danishefsky SJ. Development of efficient methods for accomplishing cysteine-free peptide and glycopeptide coupling. Angewandte Chemie (International Ed. in English). 46: 7383-7. PMID 17828726 DOI: 10.1002/anie.200702865  1
2007 Krauss IJ, Joyce JG, Finnefrock AC, Song HC, Dudkin VY, Geng X, Warren JD, Chastain M, Shiver JW, Danishefsky SJ. Fully synthetic carbohydrate HIV antigens designed on the logic of the 2G12 antibody. Journal of the American Chemical Society. 129: 11042-4. PMID 17711286 DOI: 10.1021/ja074804r  1
2007 Velthuisen EJ, Danishefsky SJ. Total synthesis of (+)-suaveolindole: establishment of its absolute configuration. Journal of the American Chemical Society. 129: 10640-1. PMID 17696355 DOI: 10.1021/ja075100k  1
2007 Min SJ, Jones GO, Houk KN, Danishefsky SJ. Creating quaternary centers with high exo stereoselectivity using activated alpha-alkynyl dienophiles. Journal of the American Chemical Society. 129: 10078-9. PMID 17655309 DOI: 10.1021/ja073528d  1
2007 Wilson RM, Danishefsky SJ. Applications of total synthesis toward the discovery of clinically useful anticancer agents. Chemical Society Reviews. 36: 1207-26. PMID 17619682 DOI: 10.1039/b611967k  1
2007 Krauss IJ, Mandal M, Danishefsky SJ. Total synthesis of (+)-isomigrastatin. Angewandte Chemie (International Ed. in English). 46: 5576-9. PMID 17583888 DOI: 10.1002/anie.200701837  1
2007 Wilson RM, Danishefsky SJ. Pattern recognition in retrosynthetic analysis: snapshots in total synthesis. The Journal of Organic Chemistry. 72: 4293-305. PMID 17539594 DOI: 10.1021/jo070871s  1
2007 Angeles AR, Dorn DC, Kou CA, Moore MA, Danishefsky SJ. Total synthesis of peribysin E necessitates revision of the assignment of its absolute configuration. Angewandte Chemie (International Ed. in English). 46: 1451-4. PMID 17387656 DOI: 10.1002/anie.200604308  1
2007 Li C, Chan C, Heimann AC, Danishefsky SJ. Total synthesis of phalarine. Angewandte Chemie (International Ed. in English). 46: 1448-50. PMID 17387655 DOI: 10.1002/anie.200604072  1
2007 Li C, Chan C, Heimann AC, Danishefsky SJ. On the rearrangement of an azaspiroindolenine to a precursor to phalarine: mechanistic insights. Angewandte Chemie (International Ed. in English). 46: 1444-7. PMID 17387654 DOI: 10.1002/anie.200604071  1
2007 Pérez L, Danishefsky SJ. Chemistry and biology in search of antimetastatic agents. Acs Chemical Biology. 2: 159-62. PMID 17373763 DOI: 10.1021/cb7000395  1
2007 Dai M, Danishefsky SJ. The total synthesis of spirotenuipesines A and B. Journal of the American Chemical Society. 129: 3498-9. PMID 17335213 DOI: 10.1021/ja069164r  1
2007 Min SJ, Danishefsky SJ. Total synthesis of paecilomycine A. Angewandte Chemie (International Ed. in English). 46: 2199-202. PMID 17300126 DOI: 10.1002/anie.200605058  1
2007 Dai M, Sarlah D, Yu M, Danishefsky SJ, Jones GO, Houk KN. Highly selective Diels-Alder reactions of directly connected enyne dienophiles. Journal of the American Chemical Society. 129: 645-57. PMID 17227028 DOI: 10.1021/ja065762u  1
2007 Wilson RM, Danishefsky SJ. Promising agents at the interface of biology and oncology derived through chemical synthesis Pure and Applied Chemistry. 79: 2189-2216. DOI: 10.1351/pac200779122189  1
2007 Wilson RM, Danishefsky SJ. Fully Synthetic Carboyhydrate-Based Antitumor Vaccines Cancer Vaccines and Tumor Immunity. 13-27. DOI: 10.1002/9780470170113.ch2  1
2007 Danishefsky SJ. Tackling medicinal chemistry Chemical and Engineering News. 85: 41-42.  1
2007 Maloney DJ, Danishefsky SJ. Studies toward the total synthesis of grandisine a: Synthesis of 9-epi-grandisine A Heterocycles. 72: 167-174.  1
2006 Chen J, Chen G, Wu B, Wan Q, Tan Z, Hua Z, Danishefsky SJ. Mature Homogeneous Erythropoietin-Level Building Blocks by Chemical Synthesis: The EPO 114-166 Glycopeptide Domain, Presenting the O-Linked Glycophorin. Tetrahedron Letters. 47: 8013-8016. PMID 17426819 DOI: 10.1016/j.tetlet.2006.09.045  1
2006 Cook SP, Polara A, Danishefsky SJ. The total synthesis of (+/-)-11-O-debenzoyltashironin. Journal of the American Chemical Society. 128: 16440-1. PMID 17177359 DOI: 10.1021/ja0670254  1
2006 Cook SP, Danishefsky SJ. An interesting issue of Diels-Alder selectivity discovered en route to 11-O-debenzoyltashironin. Organic Letters. 8: 5693-5. PMID 17134249 DOI: 10.1021/ol062067i  1
2006 Wilson RM, Danishefsky SJ. Small molecule natural products in the discovery of therapeutic agents: the synthesis connection. The Journal of Organic Chemistry. 71: 8329-51. PMID 17064003 DOI: 10.1021/jo0610053  1
2006 Yoshino T, Ng F, Danishefsky SJ. A total synthesis of xestodecalactone a and proof of its absolute stereochemistry: interesting observations on dienophilic control with 1,3-disubstituted nonequivalent allenes. Journal of the American Chemical Society. 128: 14185-91. PMID 17061903 DOI: 10.1021/ja064270e  1
2006 Wan Q, Chen J, Chen G, Danishefsky SJ. A potentially valuable advance in the synthesis of carbohydrate-based anticancer vaccines through extended cycloaddition chemistry. The Journal of Organic Chemistry. 71: 8244-9. PMID 17025318 DOI: 10.1021/jo061406i  1
2006 Wilson RM, Danishefsky SJ. Applications of total synthesis to problems in neurodegeneration: Fascinating chemistry along the way. Accounts of Chemical Research. 39: 539-49. PMID 16906750 DOI: 10.1021/ar068018n  1
2006 Chen G, Warren JD, Chen J, Wu B, Wan Q, Danishefsky SJ. Studies related to the relative thermodynamic stability of C-terminal peptidyl esters of O-hydroxy thiophenol: emergence of a doable strategy for non-cysteine ligation applicable to the chemical synthesis of glycopeptides. Journal of the American Chemical Society. 128: 7460-2. PMID 16756298 DOI: 10.1021/ja061588y  1
2006 Wu B, Chen J, Warren JD, Chen G, Hua Z, Danishefsky SJ. Building complex glycopeptides: Development of a cysteine-free native chemical ligation protocol. Angewandte Chemie (International Ed. in English). 45: 4116-25. PMID 16710874 DOI: 10.1002/anie.200600538  1
2006 Cheong PH, Yun H, Danishefsky SJ, Houk KN. Torsional steering controls the stereoselectivity of epoxidation in the guanacastepene a synthesis. Organic Letters. 8: 1513-6. PMID 16597098 DOI: 10.1021/ol052862g  1
2006 Zheng S, Chan C, Furuuchi T, Wright BJ, Zhou B, Guo J, Danishefsky SJ. Stereospecific formal total synthesis of ecteinascidin 743. Angewandte Chemie (International Ed. in English). 45: 1754-9. PMID 16496274 DOI: 10.1002/anie.200503983  1
2006 Chan C, Zheng S, Zhou B, Guo J, Heid RM, Wright BJ, Danishefsky SJ. The solution to a deep stereochemical conundrum: studies toward the tetrahydroisoquinoline alkaloids. Angewandte Chemie (International Ed. in English). 45: 1749-54. PMID 16496273 DOI: 10.1002/anie.200503982  1
2006 Ragupathi G, Koide F, Livingston PO, Cho YS, Endo A, Wan Q, Spassova MK, Keding SJ, Allen J, Ouerfelli O, Wilson RM, Danishefsky SJ. Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates. Journal of the American Chemical Society. 128: 2715-25. PMID 16492059 DOI: 10.1021/ja057244+  1
2006 Liu H, Siegel DR, Danishefsky SJ. Studies directed toward the synthesis of terreulactone A: rapid construction of the A, B, C rings. Organic Letters. 8: 423-5. PMID 16435850 DOI: 10.1021/ol052618p  1
2006 Siegel DR, Danishefsky SJ. Total synthesis of garsubellin A. Journal of the American Chemical Society. 128: 1048-9. PMID 16433500 DOI: 10.1021/ja057418n  1
2006 Carcache DA, Cho YS, Hua Z, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (+/-)-jiadifenin and studies directed to understanding its SAR: probing mechanistic and stereochemical issues in palladium-mediated allylation of enolate-like structures. Journal of the American Chemical Society. 128: 1016-22. PMID 16417394 DOI: 10.1021/ja056980a  1
2006 Lambert TH, Danishefsky SJ. Total synthesis of UCS1025A. Journal of the American Chemical Society. 128: 426-7. PMID 16402826 DOI: 10.1021/ja0574567  1
2006 Wu B, Tan Z, Chen G, Chen J, Hua Z, Wan Q, Ranganathan K, Danishefsky SJ. Mature homogeneous erythropoietin building blocks by chemical synthesis: the EPO 22-37 glycopeptide domain presenting the full N-linked dodecasaccharide Tetrahedron Letters. 47: 8009-8011. DOI: 10.1016/j.tetlet.2006.09.050  1
2006 Yun H, Gagnon A, Danishefsky SJ. Toward the synthesis of xestocyclamine A: investigation of double Michael reaction and direct aza Diels-Alder reaction Tetrahedron Letters. 47: 5311-5315. DOI: 10.1016/j.tetlet.2006.05.126  1
2006 Wu B, Hua Z, Warren JD, Ranganathan K, Wan Q, Chen G, Tan Z, Chen J, Endo A, Danishefsky SJ. Synthesis of the fucosylated biantennary N-glycan of erythropoietin Tetrahedron Letters. 47: 5577-5579. DOI: 10.1016/j.tetlet.2006.05.086  1
2006 Chan C, Li C, Zhang F, Danishefsky SJ. Studies toward the total synthesis of phalarine: a survey of some biomimetic possibilities Tetrahedron Letters. 47: 4839-4841. DOI: 10.1016/j.tetlet.2006.05.041  1
2006 Wu B, Warren JD, Chen J, Chen G, Hua Z, Danishefsky SJ. Reiterative cysteine-based coupling leading to complex, homogeneous glycopeptides Tetrahedron Letters. 47: 5219-5223. DOI: 10.1016/j.tetlet.2006.04.132  1
2006 Chen J, Warren JD, Wu B, Chen G, Wan Q, Danishefsky SJ. A route to cyclic peptides and glycopeptides by native chemical ligation using in situ derived thioesters Tetrahedron Letters. 47: 1969-1972. DOI: 10.1016/j.tetlet.2006.01.077  1
2006 Li C, Danishefsky SJ. Studies directed toward the synthesis of the guanidine alkaloid, spiroleucettadine: Some observations at the level of structure Tetrahedron Letters. 47: 385-387. DOI: 10.1016/j.tetlet.2005.11.002  1
2006 Wang ZG, Warren JD, Dudkin VY, Zhang X, Iserloh U, Visser M, Eckhardt M, Seeberger PH, Danishefsky SJ. A highly convergent synthesis of an N-linked glycopeptide presenting the H-type 2 human blood group determinant Tetrahedron. 62: 4954-4978. DOI: 10.1016/j.tet.2006.02.080  1
2006 Chan C, Danishefsky SJ. Synthetic studies toward cribrostatin IV: An intriguing epimerization Heterocycles. 70: 113-118.  1
2005 Mandal M, Yun H, Dudley GB, Lin S, Tan DS, Danishefsky SJ. Total synthesis of guanacastepene a: a route to enantiomeric control. The Journal of Organic Chemistry. 70: 10619-37. PMID 16355979 DOI: 10.1021/jo051470k  1
2005 Yun H, Chou TC, Dong H, Tian Y, Li YM, Danishefsky SJ. Total synthesis as a resource in drug discovery: the first in vivo evaluation of panaxytriol and its derivatives. The Journal of Organic Chemistry. 70: 10375-80. PMID 16323847 DOI: 10.1021/jo0515475  1
2005 Hua Z, Carcache DA, Tian Y, Li YM, Danishefsky SJ. The synthesis and preliminary biological evaluation of a novel steroid with neurotrophic activity: NGA0187. The Journal of Organic Chemistry. 70: 9849-56. PMID 16292815 DOI: 10.1021/jo051556d  1
2005 Chou TC, Dong H, Zhang X, Tong WP, Danishefsky SJ. Therapeutic cure against human tumor xenografts in nude mice by a microtubule stabilization agent, fludelone, via parenteral or oral route. Cancer Research. 65: 9445-54. PMID 16230408 DOI: 10.1158/0008-5472.CAN-05-1014  1
2005 Ouerfelli O, Warren JD, Wilson RM, Danishefsky SJ. Synthetic carbohydrate-based antitumor vaccines: challenges and opportunities. Expert Review of Vaccines. 4: 677-85. PMID 16221069 DOI: 10.1586/14760584.4.5.677  1
2005 Waters SP, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (-)-scabronine G, an inducer of neurotrophic factor production. Journal of the American Chemical Society. 127: 13514-5. PMID 16190712 DOI: 10.1021/ja055220x  1
2005 Wu KD, Cho YS, Katz J, Ponomarev V, Chen-Kiang S, Danishefsky SJ, Moore MA. Investigation of antitumor effects of synthetic epothilone analogs in human myeloma models in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 10640-5. PMID 16030145 DOI: 10.1073/pnas.0504512102  1
2005 Cho YS, Wan Q, Danishefsky SJ. Organic synthesis in pursuit of immunology: large-scale synthesis of peracetylated GM2 glycosylamino acid for preparation of a multiantigenic prostate cancer vaccine. Bioorganic & Medicinal Chemistry. 13: 5259-66. PMID 16006132 DOI: 10.1016/j.bmc.2005.06.018  1
2005 Endo A, Danishefsky SJ. Total synthesis of salinosporamide A. Journal of the American Chemical Society. 127: 8298-9. PMID 15941259 DOI: 10.1021/ja0522783  1
2005 Rivkin A, Chou TC, Danishefsky SJ. On the remarkable antitumor properties of fludelone: how we got there. Angewandte Chemie (International Ed. in English). 44: 2838-50. PMID 15880547 DOI: 10.1002/anie.200461751  1
2005 Chou TC, Guan Y, Soenen DR, Danishefsky SJ, Boger DL. Potent reversal of multidrug resistance by ningalins and its use in drug combinations against human colon carcinoma xenograft in nude mice. Cancer Chemotherapy and Pharmacology. 56: 379-90. PMID 15875185 DOI: 10.1007/s00280-005-1019-y  1
2005 Spassova MK, Bornmann WG, Ragupathi G, Sukenick G, Livingston PO, Danishefsky SJ. Synthesis of selected LeY and KH-1 analogues: a medicinal chemistry approach to vaccine optimization. The Journal of Organic Chemistry. 70: 3383-95. PMID 15844973 DOI: 10.1021/jo048016l  1
2005 Chan C, Heid R, Zheng S, Guo J, Zhou B, Furuuchi T, Danishefsky SJ. Total synthesis of cribrostatin IV: fine-tuning the character of an amide bond by remote control. Journal of the American Chemical Society. 127: 4596-8. PMID 15796524 DOI: 10.1021/ja050203t  1
2005 Shan D, Chen L, Njardarson JT, Gaul C, Ma X, Danishefsky SJ, Huang XY. Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 3772-6. PMID 15728385 DOI: 10.1073/pnas.0500658102  1
2005 Meng Z, Danishefsky SJ. A synthetic pathway to either enantiomer of merrilactone A. Angewandte Chemie (International Ed. in English). 44: 1511-3. PMID 15690391 DOI: 10.1002/anie.200462509  1
2005 Kagan E, Ragupathi G, Yi SS, Reis CA, Gildersleeve J, Kahne D, Clausen H, Danishefsky SJ, Livingston PO. Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunology, Immunotherapy : Cii. 54: 424-30. PMID 15625606 DOI: 10.1007/s00262-004-0584-y  1
2005 Yun H, Meng Z, Danishefsky SJ. Enantiotopic synthesis of natural products: Merrilactone and guanacastepene Heterocycles. 66: 711-725. DOI: 10.3987/REV-05-SR(K)2  1
2005 Cho YS, Wu KD, Moore MAS, Chou TC, Danishefsky SJ. Second-generation epothilones: Discovery of fludelone and its extraordinary antitumor properties Drugs of the Future. 30: 737-745. DOI: 10.1358/dof.2005.030.07.895806  1
2005 Wan Q, Young SC, Lambert TH, Danishefsky SJ. Olefin cross-metathesis: A powerful tool for constructing vaccines composed of multimeric antigens Journal of Carbohydrate Chemistry. 24: 425-440. DOI: 10.1081/CAR-200066992  1
2005 Yun H, Danishefsky SJ. A protocol to accomplish 'homo-Robinson' annulation: Application to the guanacastepene problem Tetrahedron Letters. 46: 3879-3882. DOI: 10.1016/j.tetlet.2005.03.191  1
2005 Cook SP, Christoph G, Danishefsky SJ. En route to the total synthesis of tashironin: On the exercise of stereochemical control by a methyl group in mediating remote cyclization reactions Tetrahedron Letters. 46: 843-847. DOI: 10.1016/j.tetlet.2004.11.148  1
2004 Bergstralh DT, Taxman DJ, Chou TC, Danishefsky SJ, Ting JP. A comparison of signaling activities induced by Taxol and desoxyepothilone B. Journal of Chemotherapy (Florence, Italy). 16: 563-76. PMID 15700849 DOI: 10.1179/joc.2004.16.6.563  1
2004 Cho YS, Carcache DA, Tian Y, Li YM, Danishefsky SJ. Total synthesis of (+/-)-jiadifenin, a non-peptidyl neurotrophic modulator. Journal of the American Chemical Society. 126: 14358-9. PMID 15521747 DOI: 10.1021/ja045939p  1
2004 Krug LM, Ragupathi G, Hood C, Kris MG, Miller VA, Allen JR, Keding SJ, Danishefsky SJ, Gomez J, Tyson L, Pizzo B, Baez V, Livingston PO. Vaccination of patients with small-cell lung cancer with synthetic fucosyl GM-1 conjugated to keyhole limpet hemocyanin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6094-100. PMID 15447995 DOI: 10.1158/1078-0432.CCR-04-0482  1
2004 Gaul C, Njardarson JT, Shan D, Dorn DC, Wu KD, Tong WP, Huang XY, Moore MA, Danishefsky SJ. The migrastatin family: discovery of potent cell migration inhibitors by chemical synthesis. Journal of the American Chemical Society. 126: 11326-37. PMID 15355116 DOI: 10.1021/ja048779q  1
2004 Rivkin A, Yoshimura F, Gabarda AE, Cho YS, Chou TC, Dong H, Danishefsky SJ. Discovery of (E)-9,10-dehydroepothilones through chemical synthesis: on the emergence of 26-trifluoro-(E)-9,10-dehydro-12,13-desoxyepothilone B as a promising anticancer drug candidate. Journal of the American Chemical Society. 126: 10913-22. PMID 15339176 DOI: 10.1021/ja046992g  1
2004 Dudkin VY, Orlova M, Geng X, Mandal M, Olson WC, Danishefsky SJ. Toward fully synthetic carbohydrate-based HIV antigen design: on the critical role of bivalency. Journal of the American Chemical Society. 126: 9560-2. PMID 15291558 DOI: 10.1021/ja047720g  1
2004 Keding SJ, Danishefsky SJ. Prospects for total synthesis: a vision for a totally synthetic vaccine targeting epithelial tumors. Proceedings of the National Academy of Sciences of the United States of America. 101: 11937-42. PMID 15280546 DOI: 10.1073/pnas.0401894101  1
2004 Yang ZQ, Geng X, Solit D, Pratilas CA, Rosen N, Danishefsky SJ. New efficient synthesis of resorcinylic macrolides via ynolides: establishment of cycloproparadicicol as synthetically feasible preclinical anticancer agent based on Hsp90 as the target. Journal of the American Chemical Society. 126: 7881-9. PMID 15212536 DOI: 10.1021/ja0484348  1
2004 Warren JD, Miller JS, Keding SJ, Danishefsky SJ. Toward fully synthetic glycoproteins by ultimately convergent routes: a solution to a long-standing problem. Journal of the American Chemical Society. 126: 6576-8. PMID 15161285 DOI: 10.1021/ja0491836  1
2004 Lin S, Yang ZQ, Kwok BH, Koldobskiy M, Crews CM, Danishefsky SJ. Total synthesis of TMC-95A and -B via a new reaction leading to Z-enamides. Some preliminary findings as to SAR. Journal of the American Chemical Society. 126: 6347-55. PMID 15149232 DOI: 10.1021/ja049821k  1
2004 Geng X, Dudkin VY, Mandal M, Danishefsky SJ. In pursuit of carbohydrate-based HIV vaccines, part 2: The total synthesis of high-mannose-type gp120 fragments--evaluation of strategies directed to maximal convergence. Angewandte Chemie (International Ed. in English). 43: 2562-5. PMID 15127453 DOI: 10.1002/anie.200353626  1
2004 Mandal M, Dudkin VY, Geng X, Danishefsky SJ. In pursuit of carbohydrate-based HIV vaccines, part 1: The total synthesis of hybrid-type gp120 fragments. Angewandte Chemie (International Ed. in English). 43: 2557-61. PMID 15127452 DOI: 10.1002/anie.200353625  1
2004 Rivkin A, Cho YS, Gabarda AE, Yoshimura F, Danishefsky SJ. Application of ring-closing metathesis reactions in the synthesis of epothilones. Journal of Natural Products. 67: 139-43. PMID 14987048 DOI: 10.1021/np030540k  1
2004 Geng X, Danishefsky SJ. Total synthesis of aigialomycin D. Organic Letters. 6: 413-6. PMID 14748606 DOI: 10.1021/ol036258m  1
2004 Njardarson JT, Gaul C, Shan D, Huang XY, Danishefsky SJ. Discovery of potent cell migration inhibitors through total synthesis: lessons from structure-activity studies of (+)-migrastatin. Journal of the American Chemical Society. 126: 1038-40. PMID 14746469 DOI: 10.1021/ja039714a  1
2004 Dudkin VY, Miller JS, Danishefsky SJ. Chemical synthesis of normal and transformed PSA glycopeptides. Journal of the American Chemical Society. 126: 736-8. PMID 14733546 DOI: 10.1021/ja037988s  0.64
2004 Geng X, Yang ZQ, Danishefsky SJ. Synthetic development of radicicol and cycloproparadicicol: Highly promising anticancer agents targeting Hsp90 Synlett. 1325-1333.  1
2003 Lin H, Danishefsky SJ. Gelsemine: a thought-provoking target for total synthesis. Angewandte Chemie (International Ed. in English). 42: 36-51. PMID 19757588  0.76
2003 Siu T, Cox CD, Danishefsky SJ. Total synthesis of lactonamycinone. Angewandte Chemie (International Ed. in English). 42: 5629-34. PMID 14639735 DOI: 10.1002/anie.200352592  0.96
2003 Cox CD, Siu T, Danishefsky SJ. Studies directed toward the total synthesis of lactonamycin: control of the sense of cycloaddition of a quinone through directed intramolecular catalysis. Angewandte Chemie (International Ed. in English). 42: 5625-9. PMID 14639734 DOI: 10.1002/anie.200352591  0.96
2003 Chou TC, Dong H, Rivkin A, Yoshimura F, Gabarda AE, Cho YS, Tong WP, Danishefsky SJ. Design and total synthesis of a superior family of epothilone analogues, which eliminate xenograft tumors to a nonrelapsable state. Angewandte Chemie (International Ed. in English). 42: 4762-7. PMID 14562342 DOI: 10.1002/anie.200352361  1
2003 Yang ZQ, Danishefsky SJ. A concise route to benzofused macrolactones via ynolides: cycloproparadicicol. Journal of the American Chemical Society. 125: 9602-3. PMID 12904022 DOI: 10.1021/ja036192q  1
2003 Yamamoto K, Hentemann MF, Allen JG, Danishefsky SJ. On the total synthesis and determination of the absolute configuration of rishirilide B: exploitation of subtle effects to control the sense of cycloaddition of o-quinodimethides. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 3242-52. PMID 12866068 DOI: 10.1002/chem.200304931  0.44
2003 Ragupathi G, Koide F, Sathyan N, Kagan E, Spassova M, Bornmann W, Gregor P, Reis CA, Clausen H, Danishefsky SJ, Livingston PO. A preclinical study comparing approaches for augmenting the immunogenicity of a heptavalent KLH-conjugate vaccine against epithelial cancers. Cancer Immunology, Immunotherapy : Cii. 52: 608-16. PMID 12811527 DOI: 10.1007/s00262-003-0399-2  0.68
2003 Yoshimura F, Rivkin A, Gabarda AE, Chou TC, Dong H, Sukenick G, Morel FF, Taylor RE, Danishefsky SJ. Synthesis and conformational analysis of (E)-9,10-dehydroepothilone B: a suggestive link between the chemistry and biology of epothilones. Angewandte Chemie (International Ed. in English). 42: 2518-21. PMID 12800175 DOI: 10.1002/anie.200351407  1
2003 Yang ZQ, Kwok BH, Lin S, Koldobskiy MA, Crews CM, Danishefsky SJ. Simplified synthetic TMC-95A/B analogues retain the potency of proteasome inhibitory activity. Chembiochem : a European Journal of Chemical Biology. 4: 508-13. PMID 12794861 DOI: 10.1002/cbic.200300560  1
2003 Gaul C, Njardarson JT, Danishefsky SJ. The total synthesis of (+)-migrastatin. Journal of the American Chemical Society. 125: 6042-3. PMID 12785819 DOI: 10.1021/ja0349103  1
2003 Yun H, Danishefsky SJ. Straightforward synthesis of panaxytriol: an active component of Red Ginseng. The Journal of Organic Chemistry. 68: 4519-22. PMID 12762760 DOI: 10.1021/jo0341665  1
2003 Zhang X, Houk KN, Lin S, Danishefsky SJ. Mechanism of cis-enamide formation from N-(alpha-silyl)allyl amides: synthetic potential of stepwise dyotropic rearrangements. Journal of the American Chemical Society. 125: 5111-4. PMID 12708862 DOI: 10.1021/ja029576+  0.96
2003 Coltart DM, Danishefsky SJ. Novel synthetic approach to the 8,10-dimethyl anti-syn-anti-perhydrophenanthrene skeleton. Organic Letters. 5: 1289-92. PMID 12688741 DOI: 10.1021/ol034213f  1
2003 Yamamoto K, Garbaccio RM, Stachel SJ, Solit DB, Chiosis G, Rosen N, Danishefsky SJ. Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol. Angewandte Chemie (International Ed. in English). 42: 1280-4. PMID 12645064 DOI: 10.1002/anie.200390329  1
2003 Rivkin A, Yoshimura F, Gabarda AE, Chou TC, Dong H, Tong WP, Danishefsky SJ. Complex target-oriented total synthesis in the drug discovery process: the discovery of a highly promising family of second generation epothilones. Journal of the American Chemical Society. 125: 2899-901. PMID 12617656 DOI: 10.1021/ja029695p  1
2003 Miller JS, Dudkin VY, Lyon GJ, Muir TW, Danishefsky SJ. Toward fully synthetic N-linked glycoproteins. Angewandte Chemie (International Ed. in English). 42: 431-4. PMID 12569509 DOI: 10.1002/anie.200390131  1
2002 Zhang F, Danishefsky SJ. An efficient stereoselective total synthesis of DL-sesquicillin, a glucocorticoid antagonist. Angewandte Chemie (International Ed. in English). 41: 1434-7. PMID 19750790  1
2002 Gagnon A, Danishefsky SJ. Evaluation of Diene hierarchies for Diels--Alder reactions en route to xestocyclamine A: elaboration of an Ansa bridge by B-alkyl Suzuki macrocyclization. Angewandte Chemie (International Ed. in English). 41: 1581-4. PMID 19750672  0.96
2002 Lin S, Dudley GB, Tan DS, Danishefsky SJ. A stereoselective route to guanacastepene A through a surprising epoxidation. Angewandte Chemie (International Ed. in English). 41: 2188-91. PMID 19746640 DOI: 10.1002/1521-3773(20020617)41:12<2188::AID-ANIE2188>3.0.CO;2-J  1
2002 Tan DS, Dudley GB, Danishefsky SJ. Synthesis of the functionalized tricyclic skeleton of guanacastepene A: a tandem epoxide-opening beta-elimination/knoevenagel cyclization. Angewandte Chemie (International Ed. in English). 41: 2185-8. PMID 19746639 DOI: 10.1002/1521-3773(20020617)41:12<2185::AID-ANIE2185>3.0.CO;2-0  1
2002 Lin S, Danishefsky SJ. The total synthesis of proteasome inhibitors TMC-95A and TMC-95B: discovery of a new method to generate cis-propenyl amides. Angewandte Chemie (International Ed. in English). 41: 512-5. PMID 12491396 DOI: 10.1002/1521-3773(20020201)41:3<512::AID-ANIE512>3.0.CO;2-R  0.76
2002 Njardarson JT, Biswas K, Danishefsky SJ. Application of hitherto unexplored macrocyclization strategies in the epothilone series: novel epothilone analogs by total synthesis. Chemical Communications (Cambridge, England). 2759-61. PMID 12478733  1
2002 Rivkin A, Biswas K, Chou TC, Danishefsky SJ. On the introduction of a trifluoromethyl substituent in the epothilone setting: chemical issues related to ring forming olefin metathesis and earliest biological findings. Organic Letters. 4: 4081-4. PMID 12423091 DOI: 10.1021/ol0268283  1
2002 Rivkin A, Njardarson JT, Biswas K, Chou TC, Danishefsky SJ. Total syntheses of [17]- and [18]dehydrodesoxyepothilones B via a concise ring-closing metathesis-based strategy: correlation of ring size with biological activity in the epothilone series. The Journal of Organic Chemistry. 67: 7737-40. PMID 12398497 DOI: 10.1021/jo0204294  1
2002 Chappell MD, Harris CR, Kuduk SD, Balog A, Wu Z, Zhang F, Lee CB, Stachel SJ, Danishefsky SJ, Chou TC, Guan Y. Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. The Journal of Organic Chemistry. 67: 7730-6. PMID 12398496  1
2002 Ragupathi G, Coltart DM, Williams LJ, Koide F, Kagan E, Allen J, Harris C, Glunz PW, Livingston PO, Danishefsky SJ. On the power of chemical synthesis: immunological evaluation of models for multiantigenic carbohydrate-based cancer vaccines. Proceedings of the National Academy of Sciences of the United States of America. 99: 13699-704. PMID 12359877 DOI: 10.1073/pnas.202427599  1
2002 Ujaque G, Lee PS, Houk KN, Hentemann MF, Danishefsky SJ. The origin of endo stereoselectivity in the hetero-Diels-Alder reactions of aldehydes with ortho-xylylenes: CH-pi, pi-pi, and steric effects on stereoselectivity. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 3423-30. PMID 12203322 DOI: 10.1002/1521-3765(20020802)8:15<3423::AID-CHEM3423>3.0.CO;2-X  0.8
2002 Coltart DM, Royyuru AK, Williams LJ, Glunz PW, Sames D, Kuduk SD, Schwarz JB, Chen XT, Danishefsky SJ, Live DH. Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomains. Journal of the American Chemical Society. 124: 9833-44. PMID 12175243 DOI: 10.1021/ja020208f  1
2002 Biswas K, Lin H, Njardarson JT, Chappell MD, Chou TC, Guan Y, Tong WP, He L, Horwitz SB, Danishefsky SJ. Highly concise routes to epothilones: the total synthesis and evaluation of epothilone 490. Journal of the American Chemical Society. 124: 9825-32. PMID 12175242 DOI: 10.1021/ja0262333  1
2002 Ng FW, Lin H, Chiu P, Danishefsky SJ. Explorations in organic chemistry leading to the total synthesis of (+/-)-gelsemine. Journal of the American Chemical Society. 124: 9812-24. PMID 12175241  0.76
2002 Ragupathi G, Deshpande PP, Coltart DM, Kim HM, Williams LJ, Danishefsky SJ, Livingston PO. Constructing an adenocarcinoma vaccine: immunization of mice with synthetic KH-1 nonasaccharide stimulates anti-KH-1 and anti-Le(y) antibodies. International Journal of Cancer. Journal International Du Cancer. 99: 207-12. PMID 11979435 DOI: 10.1002/ijc.10305  1
2002 Birman VB, Danishefsky SJ. The total synthesis of (+/-)-merrilactone A. Journal of the American Chemical Society. 124: 2080-1. PMID 11878938 DOI: 10.1021/ja012495d  1
2002 Ragupathi G, Cappello S, Yi SS, Canter D, Spassova M, Bornmann WG, Danishefsky SJ, Livingston PO. Comparison of antibody titers after immunization with monovalent or tetravalent KLH conjugate vaccines Vaccine. 20: 1030-1038. PMID 11803062 DOI: 10.1016/S0264-410X(01)00451-0  1
2002 Zhou B, Guo J, Danishefsky SJ. Studies directed to the total synthesis of ET 743 and analogues thereof: an expeditious route to the ABFGH subunit. Organic Letters. 4: 43-6. PMID 11772086 DOI: 10.1021/ol016844k  1
2001 Carson MW, Kim G, Danishefsky SJ. Total Synthesis and Proof of Stereochemistry of Natural and Unnatural Pinnaic Acids: A Remarkable Long-Range Stereochemical Effect in the Reduction of 17-Oxo Precursors of the Pinnaic Acids This work was supported by the National Institutes of Health (Grant Numbers: CA28824). Postdoctoral Fellowship support is gratefully acknowledged by M.W.C. (U.S. Army BCRP, DAMD17-98-1-8154). We thank Dr. George Sukenick of the MSKCC NMR Core Facility for NMR and mass spectral analyses. We would like to thank professor Nakanishi for his supportive interest in the project. Angewandte Chemie (International Ed. in English). 40: 4453-4456. PMID 12404443 DOI: 10.1002/1521-3773(20011203)40:23<4453::AID-ANIE4453>3.0.CO;2-4  0.44
2001 Carson MW, Kim G, Hentemann MF, Trauner D, Danishefsky SJ. Concise Stereoselective Routes to Advanced Intermediates Related to Natural and Unnatural Pinnaic Acid This work was supported by the National Institutes of Health (Grant Numbers: CA28824). Postdoctoral Fellowship support is gratefully acknowledged by M.W.C. (U.S. Army BCRP, DAMD17-98-1-8154), M.F.H. (5T32 CA62948-05), and D.T. (Schering Research Foundation, Berlin). We thank Dr. George Sukenick of the MSKCC NMR Core Facility for NMR and mass spectral analyses. Angewandte Chemie (International Ed. in English). 40: 4450-4452. PMID 12404442 DOI: 10.1002/1521-3773(20011203)40:23<4450::AID-ANIE4450>3.0.CO;2-M  0.88
2001 Siu T, Qin D, Danishefsky SJ. The Total Synthesis of Heliquinomycinone This work was supported by the National Institutes of Health (Grant numbers: AI 16943 and HL25848). The authors thank Dr. Makoto Chino of Nippon Kayaku Co., Ltd. for kindly providing a sample of heliquinomycin, and Yashuiro Itagaki of Columbia University for high-resolution mass spectral analyses. Angewandte Chemie (International Ed. in English). 40: 4713-4716. PMID 12404392 DOI: 10.1002/1521-3773(20011217)40:24<4713::AID-ANIE4713>3.0.CO;2-N  0.96
2001 Qin D, Ren RX, Siu T, Zheng C, Danishefsky SJ. Studies in the Total Synthesis of Heliquinomycinone: Proof of Concept and Assembly of a Fully Mature Spirocyclization Precursor This work was supported by the National Institutes of Health (Grant numbers: AI 16943 and HL25848). A Postdoctoral Fellowship is gratefully acknowledged by R.X.R. (NIH, Grant Number IF32EY06750-0181). The authors thank Dr. Daniel Chen for important initial experiments, Dr. Brian Bridgewater and Prof. Ged Parkin of Columbia University for X-ray crystal structure analysis of 11 a, and Yashuiro Itagaki for high-resolution mass spectral analyses. Angewandte Chemie (International Ed. in English). 40: 4709-4713. PMID 12404391 DOI: 10.1002/1521-3773(20011217)40:24<4709::AID-ANIE4709>3.0.CO;2-Q  0.96
2001 Chemler SR, Trauner D, Danishefsky SJ. The B-Alkyl Suzuki-Miyaura Cross-Coupling Reaction: Development, Mechanistic Study, and Applications in Natural Product Synthesis A list of abbreviations can be found at the end of the article. Angewandte Chemie (International Ed. in English). 40: 4544-4568. PMID 12404358 DOI: 10.1002/1521-3773(20011217)40:24<4544::AID-ANIE4544>3.0.CO;2-N  1
2001 Lee CB, Wu Z, Zhang F, Chappell MD, Stachel SJ, Chou TC, Guan Y, Danishefsky SJ. Insights into long-range structural effects on the stereochemistry of aldol condensations: a practical total synthesis of desoxyepothilone F. Journal of the American Chemical Society. 123: 5249-59. PMID 11457387  1
2001 Inoue M, Carson MW, Frontier AJ, Danishefsky SJ. Total synthesis and determination of the absolute configuration of frondosin B. Journal of the American Chemical Society. 123: 1878-89. PMID 11456808 DOI: 10.1021/ja0021060  1
2001 Lin S, Danishefsky SJ. Synthesis of the Functionalized Macrocyclic Core of Proteasome Inhibitors TMC-95A and B This work was supported by grants from the National Institutes of Health (grant CA28824). We thank Dr. George Sukenick and Sylvi Rusli of the MSKCC NMR Core Facility for NMR and mass spectral analyses (NIH Grant CA08748). Angewandte Chemie (International Ed. in English). 40: 1967-1970. PMID 11385688 DOI: 10.1002/1521-3773(20010518)40:10<1967::AID-ANIE1967>3.0.CO;2-Q  0.76
2001 Wang ZG, Zhang X, Visser M, Live D, Zatorski A, Iserloh U, Lloyd KO, Danishefsky SJ. Toward Fully Synthetic Homogeneous Glycoproteins: A High Mannose Core Containing Glycopeptide Carrying Full H-Type 2 Human Blood Group Specificity This work was supported by the National Institutes of Health (Grant nos.: HL-25848 and CA-28824 (to S.J.D.), and CA-710506 (to K.O.L.)). Postdoctoral fellowship support is gratefully acknowledged by Z.-G.W. (US Army breast cancer grant no.: DAMD17-97-1-7119) and M.V. (NIH grant no.: CA-62948-04). We gratefully acknowledge Dr. George Sukenick of the Sloan-Kettering Institute's NMR core facility for mass spectral and NMR spectroscopic analyses (SKI core grant no.: CA-08748). Angewandte Chemie (International Ed. in English). 40: 1728-1732. PMID 11353493 DOI: 10.1002/1521-3773(20010504)40:9<1728::AID-ANIE17280>3.0.CO;2-1  0.96
2001 Live DH, Wang ZG, Iserloh U, Danishefsky SJ. A strategy for probing the autonomy of cross-domain stereochemical communication in glycoconjugates. Organic Letters. 3: 851-4. PMID 11263898 DOI: 10.1021/ol0070233  0.96
2001 Tan Q, Danishefsky SJ. The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses. Angewandte Chemie (International Ed. in English). 40: 647. PMID 11241592 DOI: 10.1002/1521-3773(20010216)40:4<647::AID-ANIE6473>3.0.CO;2-G  0.72
2001 Wang ZG, Zhang X, Live D, Danishefsky SJ. From Glycals to Glycopeptides: A Convergent and Stereoselective Total Synthesis of a High Mannose N-Linked Glycopeptide This work was supported by the National Institutes of Health (Grant Numbers AI16943/CA28824). We thank Dr. George Sukenick of the MSKCC NMR Core Facility for NMR and mass spectral analyses (NIH Grant Number: CA08748). Angewandte Chemie (International Ed. in English). 40: 647. PMID 11241590 DOI: 10.1002/1521-3773(20010216)40:4<647::AID-ANIE6471>3.0.CO;2-M  0.96
2000 Wu Z, Williams LJ, Danishefsky SJ. A Three-Step Entry to the Aspirochlorine Family of Antifungal Agents. Angewandte Chemie (International Ed. in English). 39: 3866-3868. PMID 29711678 DOI: 10.1002/1521-3773(20001103)39:21<3866::AID-ANIE3866>3.0.CO;2-E  1
2000 Tan Q, Danishefsky SJ. The Synthesis of CP-263,114 and CP-225,917: Striking Long-Range Stereocontrol in the Fashioning of C7 Financial support was provided by the National Institutes of Health (Grant nos. CA-28824 and HL-25848 for S.J.D., CA-08748 for the Sloan-Kettering Institute Core Facility). Q.T. gratefully acknowledges the US Department of Defense for a postdoctoral fellowship (U.S. Army grant no. DAMD-17-99-1-9373). We thank the Pfizer Corporation, particularly Dr. T. Kaneko and Dr. T. T. Dabrah for discussions and for providing valuable CP samples from fermentation broth. We are grateful to Dr. Dongfang Meng for his major contributions to this work. We also thank George Sukenick of the Sloan-Kettering Institute Core Facility for mass spectral analyses and assistance in NMR spectroscopic and HPLC analyses, and Sylvi Rusli for mass spectral analyses. Angewandte Chemie (International Ed. in English). 39: 4509-4511. PMID 11169652 DOI: 10.1002/1521-3773(20001215)39:24<4509::AID-ANIE4509>3.0.CO;2-F  0.72
2000 Wu Z, Zhang F, Danishefsky SJ. Subtle Variations in the Long-Range Transmission of Stereochemical Information: Matched and Mismatched Aldol Reactions This work was supported by the National Institutes of Health (Grant Nos. CA-28824 and HL-25848). Angewandte Chemie (International Ed. in English). 39: 4505-4508. PMID 11169651 DOI: 10.1002/1521-3773(20001215)39:24<4505::AID-ANIE4505>3.0.CO;2-2  1
2000 Wang ZG, Zhang X, Live D, Danishefsky SJ. From Glycals to Glycopeptides: A Convergent and Stereoselective Total Synthesis of a High Mannose N-Linked Glycopeptide This work was supported by the National Institutes of Health (Grant Numbers AI16943/CA28824). We thank Dr. George Sukenick of the MSKCC NMR Core Facility for NMR and mass spectral analyses (NIH Grant Number: CA08748). Angewandte Chemie (International Ed. in English). 39: 3652-3656. PMID 11091428 DOI: 10.1002/1521-3773(20001016)39:20<3652::AID-ANIE3652>3.0.CO;2-B  0.96
2000 Danishefsky SJ, Inoue M, Trauner D. Synthesis of immunomodulatory marine natural products. Ernst Schering Research Foundation Workshop. 1-24. PMID 11077604  0.88
2000 Lee CB, Chou TC, Zhang XG, Wang ZG, Kuduk SD, Chappell MD, Stachel SJ, Danishefsky SJ. Total synthesis and antitumor activity of 12,13-desoxyepothilone F: an unexpected solvolysis problem at C15, mediated by remote substitution at C21. The Journal of Organic Chemistry. 65: 6525-33. PMID 11052097  0.96
2000 Martello LA, McDaid HM, Regl DL, Yang CP, Meng D, Pettus TR, Kaufman MD, Arimoto H, Danishefsky SJ, Smith AB, Horwitz SB. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 1978-87. PMID 10815923  0.84
2000 Inoue M, Frontier AJ, Danishefsky SJ. The Total Synthesis of Frondosin B. Angewandte Chemie (International Ed. in English). 39: 761-764. PMID 10760861 DOI: 10.1002/(SICI)1521-3773(20000218)39:4<761::AID-ANIE761>3.0.CO;2-I  1
2000 Wang ZG, Williams LJ, Zhang XF, Zatorski A, Kudryashov V, Ragupathi G, Spassova M, Bornmann W, Slovin SF, Scher HI, Livingston PO, Lloyd KO, Danishefsky SJ. Polyclonal antibodies from patients immunized with a globo H-keyhole limpet hemocyanin vaccine: isolation, quantification, and characterization of immune responses by using totally synthetic immobilized tumor antigens. Proceedings of the National Academy of Sciences of the United States of America. 97: 2719-24. PMID 10716997  0.96
1999 Ragupathi G, Slovin SF, Adluri S, Sames D, Kim IJ, Kim HM, Spassova M, Bornmann WG, Lloyd KO, Scher HI, Livingston PO, Danishefsky SJ. A Fully Synthetic Globo H Carbohydrate Vaccine Induces a Focused Humoral Response in Prostate Cancer Patients: A Proof of Principle. Angewandte Chemie (International Ed. in English). 38: 563-566. PMID 29711780 DOI: 10.1002/(SICI)1521-3773(19990215)38:4<563::AID-ANIE563>3.0.CO;2-3  0.96
1999 Meng D, Danishefsky SJ. Stereospecific Sulfur-Mediated Cleavage of a Spirocyclobutanone: Synthesis of a Fully Functional Precursor to the CP Compounds. Angewandte Chemie (International Ed. in English). 38: 1485-1488. PMID 29711567 DOI: 10.1002/(SICI)1521-3773(19990517)38:10<1485::AID-ANIE1485>3.0.CO;2-1  0.84
1999 Sepp-Lorenzino L, Balog A, Su DS, Meng D, Timaul N, Scher HI, Danishefsky SJ, Rosen N. The microtubule-stabilizing agents epothilones A and B and their desoxy-derivatives induce mitotic arrest and apoptosis in human prostate cancer cells. Prostate Cancer and Prostatic Diseases. 2: 41-52. PMID 12496865 DOI: 10.1038/sj.pcan.4500282  0.84
1999 Trauner D, Schwarz JB, Danishefsky SJ. Total Synthesis of (+)-Halichlorine: An Inhibitor of VCAM-1 Expression. Angewandte Chemie (International Ed. in English). 38: 3542-3545. PMID 10602236 DOI: 10.1002/(SICI)1521-3773(19991203)38:23<3542::AID-ANIE3542>3.0.CO;2-I  0.88
1999 Live DH, Williams LJ, Kuduk SD, Schwarz JB, Glunz PW, Chen XT, Sames D, Kumar RA, Danishefsky SJ. Probing cell-surface architecture through synthesis: an NMR-determined structural motif for tumor-associated mucins. Proceedings of the National Academy of Sciences of the United States of America. 96: 3489-93. PMID 10097062 DOI: 10.1073/pnas.96.7.3489  1
1998 Balog A, Harris C, Savin K, Zhang XG, Chou TC, Danishefsky SJ. A Novel Aldol Condensation with 2-Methyl-4-pentenal and Its Application to an Improved Total Synthesis of Epothilone B. Angewandte Chemie (International Ed. in English). 37: 2675-2678. PMID 29711598 DOI: 10.1002/(SICI)1521-3773(19981016)37:19<2675::AID-ANIE2675>3.0.CO;2-O  0.92
1998 Chen XT, Zhou B, Bhattacharya SK, Gutteridge CE, Pettus TRR, Danishefsky SJ. The Total Synthesis of Eleutherobin: A Surprise Ending. Angewandte Chemie (International Ed. in English). 37: 789-792. PMID 29711384 DOI: 10.1002/(SICI)1521-3773(19980403)37:6<789::AID-ANIE789>3.0.CO;2-3  0.96
1998 Zheng C, Seeberger PH, Danishefsky SJ. Amidoglycosylation of Polymer-Bound Glycals: A Complete Solid-Phase Synthesis of the Oligosaccharide Domain of the Lewis Blood Group Determinant. Angewandte Chemie (International Ed. in English). 37: 786-789. PMID 29711374 DOI: 10.1002/(SICI)1521-3773(19980403)37:6<786::AID-ANIE786>3.0.CO;2-F  0.92
1998 Kamenecka TM, Danishefsky SJ. Total Synthesis of Himastatin: Confirmation of the Revised Stereostructure. Angewandte Chemie (International Ed. in English). 37: 2995-2998. PMID 29711142 DOI: 10.1002/(SICI)1521-3773(19981116)37:21<2995::AID-ANIE2995>3.0.CO;2-6  0.56
1998 Kamenecka TM, Danishefsky SJ. Studies in the Total Synthesis of Himastatin: A Revision of the Stereochemical Assignment. Angewandte Chemie (International Ed. in English). 37: 2993-2995. PMID 29711127 DOI: 10.1002/(SICI)1521-3773(19981116)37:21<2993::AID-ANIE2993>3.0.CO;2-I  0.56
1998 Edmondson SD, Danishefsky SJ. The Total Synthesis of Spirotryprostatin A. Angewandte Chemie (International Ed. in English). 37: 1138-1140. PMID 29711010 DOI: 10.1002/(SICI)1521-3773(19980504)37:8<1138::AID-ANIE1138>3.0.CO;2-N  0.4
1997 Sames D, Chen XT, Danishefsky SJ. Convergent total synthesis of a tumour-associated mucin motif. Nature. 389: 587-91. PMID 9335496 DOI: 10.1038/39292  1
1996 Bertinato P, Sorensen EJ, Meng D, Danishefsky SJ. Studies toward a Synthesis of Epothilone A: Stereocontrolled Assembly of the Acyl Region and Models for Macrocyclization. The Journal of Organic Chemistry. 61: 8000-8001. PMID 11667778  0.84
1996 Meng D, Sorensen EJ, Bertinato P, Danishefsky SJ. Studies toward a Synthesis of Epothilone A: Use of Hydropyran Templates for the Management of Acyclic Stereochemical Relationships. The Journal of Organic Chemistry. 61: 7998-7999. PMID 11667777  0.84
1996 Seeberger PH, Cirillo PF, Hu S, Beebe X, Bilodeau MT, Danishefsky SJ. Synthesis of the pentasaccharide core structure of asparagine-linked glycoprotein oligosaccharides by the glycal assembly method. Enantiomer. 1: 311-23. PMID 9676275  0.92
1995 Roberge JY, Beebe X, Danishefsky SJ. A strategy for a convergent synthesis of N-linked glycopeptides on a solid support. Science (New York, N.Y.). 269: 202-4. PMID 7618080  0.8
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