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Year Citation  Score
2018 Krall JA, Reinhardt F, Mercury OA, Pattabiraman DR, Brooks MW, Dougan M, Lambert AW, Bierie B, Ploegh HL, Dougan SK, Weinberg RA. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Science Translational Medicine. 10. PMID 29643230 DOI: 10.1126/scitranslmed.aan3464  0.4
2018 Ingram JR, Blomberg OS, Rashidian M, Ali L, Garforth S, Fedorov E, Fedorov AA, Bonanno JB, Le Gall C, Crowley S, Espinosa C, Biary T, Keliher EJ, Weissleder R, Almo SC, ... ... Ploegh HL, et al. Anti-CTLA-4 therapy requires an Fc domain for efficacy. Proceedings of the National Academy of Sciences of the United States of America. PMID 29581255 DOI: 10.1073/pnas.1801524115  0.4
2018 Dougan M, Ingram JR, Jeong HJ, Mosaheb MM, Bruck PT, Ali L, Pishesha N, Blomberg O, Tyler PM, Servos MM, Rashidian M, Nguyen QD, von Andrian UH, Ploegh HL, Dougan SK. Targeting cytokine therapy to the pancreatic tumor microenvironment using PD-L1 specific VHHs. Cancer Immunology Research. PMID 29459478 DOI: 10.1158/2326-6066.CIR-17-0495  0.4
2017 Ingram JR, Dougan M, Rashidian M, Knoll M, Keliher EJ, Garrett S, Garforth S, Blomberg OS, Espinosa C, Bhan A, Almo SC, Weissleder R, Lodish H, Dougan SK, Ploegh HL. PD-L1 is an activation-independent marker of brown adipocytes. Nature Communications. 8: 647. PMID 28935898 DOI: 10.1038/s41467-017-00799-8  0.4
2017 Ingram JR, Blomberg OS, Sockolosky JT, Ali L, Schmidt FI, Pishesha N, Espinosa C, Dougan SK, Garcia KC, Ploegh HL, Dougan M. Localized CD47 blockade enhances immunotherapy for murine melanoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 28874561 DOI: 10.1073/pnas.1710776114  0.4
2017 Rashidian M, Ingram JR, Dougan M, Dongre A, Whang KA, LeGall C, Cragnolini JJ, Bierie B, Gostissa M, Gorman J, Grotenbreg GM, Bhan A, Weinberg RA, Ploegh HL. Predicting the response to CTLA-4 blockade by longitudinal noninvasive monitoring of CD8 T cells. The Journal of Experimental Medicine. PMID 28666979 DOI: 10.1084/jem.20161950  0.32
2017 Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets. Journal of Immunology (Baltimore, Md. : 1950). PMID 28576977 DOI: 10.4049/jimmunol.1700214  0.4
2017 Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Dhesycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL. Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28270614 DOI: 10.1073/pnas.1701746114  0.4
2017 Van Elssen CH, Rashidian M, Vrbanac V, Wucherpfennig KW, El Habre Z, Sticht J, Freund C, Jacobsen J, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh H. Noninvasive imaging of human immune responses in a human xenograft model of graft-versus-host disease. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28209904 DOI: 10.2967/jnumed.116.186007  0.32
2017 Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T. Cocapture of cognate and bystander antigens can activate autoreactive B cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 28057865 DOI: 10.1073/pnas.1614472114  0.4
2016 Bilate AM, Bousbaine D, Mesin L, Agudelo M, Leube J, Kratzert A, Dougan SK, Victora GD, Ploegh HL. Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor. Science Immunology. 1: eaaf7471. PMID 28783695 DOI: 10.1126/sciimmunol.aaf7471  0.4
2016 Truttmann MC, Zheng X, Hanke L, Damon JR, Grootveld M, Krakowiak J, Pincus D, Ploegh HL. Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response. Proceedings of the National Academy of Sciences of the United States of America. PMID 28031489 DOI: 10.1073/pnas.1619234114  0.56
2016 Swee LK, Tan ZW, Sanecka A, Yoshida N, Patel H, Grotenbreg G, Frickel EM, Ploegh HL. Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions. Open Biology. 6. PMID 27881740 DOI: 10.1098/rsob.160293  0.68
2016 Hagiwara M, Ling J, Koenig PA, Ploegh HL. Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e. Molecular Cell. PMID 27570074 DOI: 10.1016/j.molcel.2016.07.014  0.32
2016 Chahal JS, Khan OF, Cooper CL, McPartlan JS, Tsosie JK, Tilley LD, Sidik SM, Lourido S, Langer R, Bavari S, Ploegh HL, Anderson DG. Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, and Toxoplasma gondii challenges with a single dose. Proceedings of the National Academy of Sciences of the United States of America. PMID 27382155 DOI: 10.1073/pnas.1600299113  0.68
2016 Dura B, Servos MM, Barry RM, Ploegh HL, Dougan SK, Voldman J. Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture. Proceedings of the National Academy of Sciences of the United States of America. PMID 27303033 DOI: 10.1073/pnas.1515364113  0.4
2016 Sockolosky JT, Dougan M, Ingram JR, Ho CC, Kauke MJ, Almo SC, Ploegh HL, Garcia KC. Durable antitumor responses to CD47 blockade require adaptive immune stimulation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27091975 DOI: 10.1073/pnas.1604268113  0.68
2016 Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, ... ... Ploegh HL, et al. Corrigendum: CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. PMID 26982724 DOI: 10.1038/nature17421  0.68
2016 Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nature Biotechnology. 34: 210. PMID 26849523 DOI: 10.1038/nbt0216-210c  0.4
2016 Fang T, Duarte JN, Ling J, Li Z, Guzman JS, Ploegh HL. Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. Angewandte Chemie (International Ed. in English). 55: 2416-20. PMID 26840214 DOI: 10.1002/anie.201509432  0.68
2016 Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 26811477 DOI: 10.1073/pnas.1521763113  0.68
2015 Rashidian M, Wang L, Eden JG, Jacobsen JT, Hossain I, Wang Q, Victora GD, Vasdev N, Ploegh H, Liang SH. Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics. Angewandte Chemie (International Ed. in English). PMID 26630549 DOI: 10.1002/anie.201507596  0.68
2015 Chen GY, Li Z, Theile CS, Bardhan NM, Kumar PV, Duarte JN, Maruyama T, Rashidfarrokh A, Belcher AM, Ploegh HL. Graphene Oxide Nanosheets Modified with Single-Domain Antibodies for Rapid and Efficient Capture of Cells. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26472062 DOI: 10.1002/chem.201503057  0.68
2015 Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL. Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. Plos Pathogens. 11: e1005188. PMID 26431038 DOI: 10.1371/journal.ppat.1005188  0.68
2015 Ingram JR, Knockenhauer KE, Markus BM, Mandelbaum J, Ramek A, Shan Y, Shaw DE, Schwartz TU, Ploegh HL, Lourido S. Allosteric activation of apicomplexan calcium-dependent protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 112: E4975-84. PMID 26305940 DOI: 10.1073/pnas.1505914112  0.68
2015 Li Z, Theile CS, Chen GY, Bilate AM, Duarte JN, Avalos AM, Fang T, Barberena R, Sato S, Ploegh HL. Fluorophore-Conjugated Holliday Junctions for Generating Super-Bright Antibodies and Antibody Fragments. Angewandte Chemie (International Ed. in English). 54: 11706-10. PMID 26252716 DOI: 10.1002/anie.201505277  0.68
2015 Santone M, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U. A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells. Human Vaccines & Immunotherapeutics. 0. PMID 26024409 DOI: 10.1080/21645515.2015.1027467  0.68
2015 Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL. Noninvasive imaging of immune responses. Proceedings of the National Academy of Sciences of the United States of America. 112: 6146-51. PMID 25902531 DOI: 10.1073/pnas.1502609112  0.68
2015 Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nature Biotechnology. 33: 538-42. PMID 25798939 DOI: 10.1038/nbt.3190  0.68
2015 Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC. Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science (New York, N.Y.). 347: 1113-7. PMID 25745166 DOI: 10.1126/science.aaa5026  0.68
2015 Witte MD, Wu T, Guimaraes CP, Theile CS, Blom AE, Ingram JR, Li Z, Kundrat L, Goldberg SD, Ploegh HL. Site-specific protein modification using immobilized sortase in batch and continuous-flow systems. Nature Protocols. 10: 508-16. PMID 25719269 DOI: 10.1038/nprot.2015.026  0.68
2015 Jensen KD, Camejo A, Melo MB, Cordeiro C, Julien L, Grotenbreg GM, Frickel EM, Ploegh HL, Young L, Saeij JP. Toxoplasma gondii superinfection and virulence during secondary infection correlate with the exact ROP5/ROP18 allelic combination. Mbio. 6: e02280. PMID 25714710 DOI: 10.1128/mBio.02280-14  0.68
2015 Truttmann MC, Wu Q, Stiegeler S, Duarte JN, Ingram J, Ploegh HL. HypE-specific nanobodies as tools to modulate HypE-mediated target AMPylation. The Journal of Biological Chemistry. 290: 9087-100. PMID 25678711 DOI: 10.1074/jbc.M114.634287  0.68
2015 Sun C, Schattgen SA, Pisitkun P, Jorgensen JP, Hilterbrand AT, Wang LJ, West JA, Hansen K, Horan KA, Jakobsen MR, O'Hare P, Adler H, Sun R, Ploegh HL, Damania B, et al. Evasion of innate cytosolic DNA sensing by a gammaherpesvirus facilitates establishment of latent infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 1819-31. PMID 25595793 DOI: 10.4049/jimmunol.1402495  0.68
2015 Dura B, Dougan SK, Barisa M, Hoehl MM, Lo CT, Ploegh HL, Voldman J. Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing. Nature Communications. 6: 5940. PMID 25585172 DOI: 10.1038/ncomms6940  0.68
2015 Ashour J, Schmidt FI, Hanke L, Cragnolini J, Cavallari M, Altenburg A, Brewer R, Ingram J, Shoemaker C, Ploegh HL. Intracellular expression of camelid single-domain antibodies specific for influenza virus nucleoprotein uncovers distinct features of its nuclear localization. Journal of Virology. 89: 2792-800. PMID 25540369 DOI: 10.1128/JVI.02693-14  0.68
2015 Damon JR, Pincus D, Ploegh HL. tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae. Molecular Biology of the Cell. 26: 270-82. PMID 25392298 DOI: 10.1091/mbc.E14-06-1145  0.68
2015 Huang YH, Zhu C, Kondo Y, Anderson AC, Gandhi A, Russell A, Dougan SK, Petersen BS, Melum E, Pertel T, Clayton KL, Raab M, Chen Q, Beauchemin N, Yazaki PJ, ... ... Ploegh HL, et al. CEACAM1 regulates TIM-3-mediated tolerance and exhaustion. Nature. 517: 386-90. PMID 25363763 DOI: 10.1038/nature13848  0.68
2015 Swee LK, Lourido S, Bell GW, Ingram JR, Ploegh HL. One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism. Acs Chemical Biology. 10: 460-5. PMID 25360987 DOI: 10.1021/cb500462t  0.68
2015 Irvine D, Ploegh H. Editorial overview: Special section: Immunological engineering Current Opinion in Immunology. 35: ix-xi. DOI: 10.1016/j.coi.2015.07.010  0.68
2014 Wagner K, Kwakkenbos MJ, Claassen YB, Maijoor K, Böhne M, van der Sluijs KF, Witte MD, van Zoelen DJ, Cornelissen LA, Beaumont T, Bakker AQ, Ploegh HL, Spits H. Bispecific antibody generated with sortase and click chemistry has broad antiinfluenza virus activity. Proceedings of the National Academy of Sciences of the United States of America. 111: 16820-5. PMID 25385586 DOI: 10.1073/pnas.1408605111  0.68
2014 Strijbis K, Yilmaz OH, Dougan SK, Esteban A, Gröne A, Kumamoto CA, Ploegh HL. Intestinal colonization by Candida albicans alters inflammatory responses in Bruton's tyrosine kinase-deficient mice. Plos One. 9: e112472. PMID 25379804 DOI: 10.1371/journal.pone.0112472  0.68
2014 Koenig PA, Nicholls PK, Schmidt FI, Hagiwara M, Maruyama T, Frydman GH, Watson N, Page DC, Ploegh HL. The E2 ubiquitin-conjugating enzyme UBE2J1 is required for spermiogenesis in mice. The Journal of Biological Chemistry. 289: 34490-502. PMID 25320092 DOI: 10.1074/jbc.M114.604132  0.68
2014 Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M, Weissman JS. Genome-Scale CRISPR-Mediated Control of Gene Repression and Activation. Cell. 159: 647-61. PMID 25307932 DOI: 10.1016/j.cell.2014.09.029  0.68
2014 Wuethrich I, Peeters JG, Blom AE, Theile CS, Li Z, Spooner E, Ploegh HL, Guimaraes CP. Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors. Plos One. 9: e109883. PMID 25275512 DOI: 10.1371/journal.pone.0109883  0.68
2014 Lee S, Kang D, Ra EA, Lee TA, Ploegh HL, Park B. Negative self-regulation of TLR9 signaling by its N-terminal proteolytic cleavage product. Journal of Immunology (Baltimore, Md. : 1950). 193: 3726-35. PMID 25187653 DOI: 10.4049/jimmunol.1400210  0.68
2014 Koenig PA, Ploegh HL. Protein quality control in the endoplasmic reticulum. F1000prime Reports. 6: 49. PMID 25184039 DOI: 10.12703/P6-49  0.68
2014 Sosa BA, Demircioglu FE, Chen JZ, Ingram J, Ploegh HL, Schwartz TU. How lamina-associated polypeptide 1 (LAP1) activates Torsin. Elife. 3: e03239. PMID 25149450 DOI: 10.7554/eLife.03239  0.68
2014 Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR, Ploegh HL. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. The Journal of Biological Chemistry. 289: 24005-18. PMID 25031321 DOI: 10.1074/jbc.M114.589275  0.68
2014 Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF. Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes. Proceedings of the National Academy of Sciences of the United States of America. 111: 10131-6. PMID 24982154 DOI: 10.1073/pnas.1409861111  0.68
2014 Strijbis K, Ploegh HL. Secretion of circular proteins using sortase. Methods in Molecular Biology (Clifton, N.J.). 1174: 73-83. PMID 24947375 DOI: 10.1007/978-1-4939-0944-5_5  0.68
2014 Avalos AM, Meyer-Wentrup F, Ploegh HL. B-cell receptor signaling in lymphoid malignancies and autoimmunity. Advances in Immunology. 123: 1-49. PMID 24840946 DOI: 10.1016/B978-0-12-800266-7.00004-2  0.68
2014 Abdi K, Singh NJ, Spooner E, Kessler BM, Radaev S, Lantz L, Xiao TS, Matzinger P, Sun PD, Ploegh HL. Free IL-12p40 monomer is a polyfunctional adaptor for generating novel IL-12-like heterodimers extracellularly. Journal of Immunology (Baltimore, Md. : 1950). 192: 6028-36. PMID 24821971 DOI: 10.4049/jimmunol.1400159  0.68
2014 Lee CC, Freinkman E, Sabatini DM, Ploegh HL. The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D. The Journal of Biological Chemistry. 289: 17124-31. PMID 24782309 DOI: 10.1074/jbc.M114.571257  0.68
2014 Wuethrich I, Guillen E, Ploegh HL. A mouse monoclonal antibody against Alexa Fluor 647. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 33: 109-20. PMID 24746152 DOI: 10.1089/mab.2013.0088  0.68
2014 Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB. Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. Cancer Discovery. 4: 702-15. PMID 24705811 DOI: 10.1158/2159-8290.CD-13-0945  0.68
2014 Avalos AM, Ploegh HL. Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells. Frontiers in Immunology. 5: 92. PMID 24653721 DOI: 10.3389/fimmu.2014.00092  0.68
2014 Claessen JH, Sanyal S, Ploegh HL. The chaperone BAG6 captures dislocated glycoproteins in the cytosol. Plos One. 9: e90204. PMID 24594942 DOI: 10.1371/journal.pone.0090204  0.68
2014 Avalos AM, Bilate AM, Witte MD, Tai AK, He J, Frushicheva MP, Thill PD, Meyer-Wentrup F, Theile CS, Chakraborty AK, Zhuang X, Ploegh HL. Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. The Journal of Experimental Medicine. 211: 365-79. PMID 24493799 DOI: 10.1084/jem.20131603  0.68
2014 Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 506: 52-7. PMID 24476824 DOI: 10.1038/nature12988  0.68
2013 Ploegh HL. Logic of the immune system. Cancer Immunology Research. 1: 5-10. PMID 24777244 DOI: 10.1158/2326-6066.CIR-13-0023  0.68
2013 Dougan SK, Dougan M, Kim J, Turner JA, Ogata S, Cho HI, Jaenisch R, Celis E, Ploegh HL. Transnuclear TRP1-specific CD8 T cells with high or low affinity TCRs show equivalent antitumor activity. Cancer Immunology Research. 1: 99-111. PMID 24459675 DOI: 10.1158/2326-6066.CIR-13-0047  0.4
2013 Sarkar S, Carroll B, Buganim Y, Maetzel D, Ng AH, Cassady JP, Cohen MA, Chakraborty S, Wang H, Spooner E, Ploegh H, Gsponer J, Korolchuk VI, Jaenisch R. Impaired autophagy in the lipid-storage disorder Niemann-Pick type C1 disease. Cell Reports. 5: 1302-15. PMID 24290752 DOI: 10.1016/j.celrep.2013.10.042  0.68
2013 Sanyal S, Ashour J, Maruyama T, Altenburg AF, Cragnolini JJ, Bilate A, Avalos AM, Kundrat L, García-Sastre A, Ploegh HL. Type I interferon imposes a TSG101/ISG15 checkpoint at the Golgi for glycoprotein trafficking during influenza virus infection. Cell Host & Microbe. 14: 510-21. PMID 24237697 DOI: 10.1016/j.chom.2013.10.011  0.68
2013 Reiling JH, Olive AJ, Sanyal S, Carette JE, Brummelkamp TR, Ploegh HL, Starnbach MN, Sabatini DM. A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens. Nature Cell Biology. 15: 1473-85. PMID 24185178 DOI: 10.1038/ncb2865  0.68
2013 Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 503: 406-9. PMID 24141948 DOI: 10.1038/nature12637  0.68
2013 Witte MD, Theile CS, Wu T, Guimaraes CP, Blom AE, Ploegh HL. Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry. Nature Protocols. 8: 1808-19. PMID 23989675 DOI: 10.1038/nprot.2013.103  0.68
2013 Theile CS, Witte MD, Blom AE, Kundrat L, Ploegh HL, Guimaraes CP. Site-specific N-terminal labeling of proteins using sortase-mediated reactions. Nature Protocols. 8: 1800-7. PMID 23989674 DOI: 10.1038/nprot.2013.102  0.68
2013 Guimaraes CP, Witte MD, Theile CS, Bozkurt G, Kundrat L, Blom AE, Ploegh HL. Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions. Nature Protocols. 8: 1787-99. PMID 23989673 DOI: 10.1038/nprot.2013.101  0.68
2013 Fang M, Xie H, Dougan SK, Ploegh H, van Oudenaarden A. Stochastic cytokine expression induces mixed T helper cell States. Plos Biology. 11: e1001618. PMID 23935453 DOI: 10.1371/journal.pbio.1001618  0.68
2013 Cai X, Xu Y, Cheung AK, Tomlinson RC, Alcázar-Román A, Murphy L, Billich A, Zhang B, Feng Y, Klumpp M, Rondeau JM, Fazal AN, Wilson CJ, Myer V, Joberty G, ... ... Ploegh HL, et al. PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling. Chemistry & Biology. 20: 912-21. PMID 23890009 DOI: 10.1016/j.chembiol.2013.05.010  0.68
2013 Lee CC, Carette JE, Brummelkamp TR, Ploegh HL. A reporter screen in a human haploid cell line identifies CYLD as a constitutive inhibitor of NF-κB. Plos One. 8: e70339. PMID 23861985 DOI: 10.1371/journal.pone.0070339  0.68
2013 Strijbis K, Tafesse FG, Fairn GD, Witte MD, Dougan SK, Watson N, Spooner E, Esteban A, Vyas VK, Fink GR, Grinstein S, Ploegh HL. Bruton's Tyrosine Kinase (BTK) and Vav1 contribute to Dectin1-dependent phagocytosis of Candida albicans in macrophages. Plos Pathogens. 9: e1003446. PMID 23825946 DOI: 10.1371/journal.ppat.1003446  0.68
2013 Koenig PA, Spooner E, Kawamoto N, Strominger JL, Ploegh HL. Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs. Journal of Immunology (Baltimore, Md. : 1950). 191: 208-16. PMID 23740953 DOI: 10.4049/jimmunol.1300345  0.68
2013 Hess GT, Guimaraes CP, Spooner E, Ploegh HL, Belcher AM. Orthogonal labeling of M13 minor capsid proteins with DNA to self-assemble end-to-end multiphage structures. Acs Synthetic Biology. 2: 490-6. PMID 23713956 DOI: 10.1021/sb400019s  0.68
2013 Kim J, Huh J, Hwang M, Kwon EH, Jung DJ, Brinkmann MM, Jang MH, Ploegh HL, Kim YM. Acidic amino acid residues in the juxtamembrane region of the nucleotide-sensing TLRs are important for UNC93B1 binding and signaling. Journal of Immunology (Baltimore, Md. : 1950). 190: 5287-95. PMID 23585677 DOI: 10.4049/jimmunol.1202767  0.68
2013 Tafesse FG, Sanyal S, Ashour J, Guimaraes CP, Hermansson M, Somerharju P, Ploegh HL. Intact sphingomyelin biosynthetic pathway is essential for intracellular transport of influenza virus glycoproteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 6406-11. PMID 23576732 DOI: 10.1073/pnas.1219909110  0.68
2013 Saha AK, Kappes F, Mundade A, Deutzmann A, Rosmarin DM, Legendre M, Chatain N, Al-Obaidi Z, Adams BS, Ploegh HL, Ferrando-May E, Mor-Vaknin N, Markovitz DM. Intercellular trafficking of the nuclear oncoprotein DEK. Proceedings of the National Academy of Sciences of the United States of America. 110: 6847-52. PMID 23569252 DOI: 10.1073/pnas.1220751110  0.68
2013 Hendricks GL, Weirich KL, Viswanathan K, Li J, Shriver ZH, Ashour J, Ploegh HL, Kurt-Jones EA, Fygenson DK, Finberg RW, Comolli JC, Wang JP. Sialylneolacto-N-tetraose c (LSTc)-bearing liposomal decoys capture influenza A virus. The Journal of Biological Chemistry. 288: 8061-73. PMID 23362274 DOI: 10.1074/jbc.M112.437202  0.68
2013 Claessen JH, Witte MD, Yoder NC, Zhu AY, Spooner E, Ploegh HL. Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infection. Chembiochem : a European Journal of Chemical Biology. 14: 343-52. PMID 23335262 DOI: 10.1002/cbic.201200701  0.68
2013 Swee LK, Guimaraes CP, Sehrawat S, Spooner E, Barrasa MI, Ploegh HL. Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes. Proceedings of the National Academy of Sciences of the United States of America. 110: 1428-33. PMID 23297227 DOI: 10.1073/pnas.1214994110  0.68
2013 Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases Science Signaling. 6. PMID 23281368 DOI: 10.1126/scisignal.2003220  0.68
2013 Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood. 121: 1145-56. PMID 23243279 DOI: 10.1182/blood-2012-08-447409  0.68
2013 Avalos AM, Kirak O, Oelkers JM, Pils MC, Kim YM, Ottinger M, Jaenisch R, Ploegh HL, Brinkmann MM. Cell-specific TLR9 trafficking in primary APCs of transgenic TLR9-GFP mice. Journal of Immunology (Baltimore, Md. : 1950). 190: 695-702. PMID 23241879 DOI: 10.4049/jimmunol.1202342  0.68
2013 Ploegh H. ElaD Peptidase (Escherichia coli) Handbook of Proteolytic Enzymes. 2: 2392-2396. DOI: 10.1016/B978-0-12-382219-2.00534-2  0.68
2013 Ploegh H. UL36 Deubiquitinylating Peptidase Handbook of Proteolytic Enzymes. 2: 2131-2134. DOI: 10.1016/B978-0-12-382219-2.00479-8  0.68
2013 Ploegh H. Ubiquitin-specific Peptidases 14 and 6 Handbook of Proteolytic Enzymes. 2: 2086-2089. DOI: 10.1016/B978-0-12-382219-2.00469-5  0.68
2012 Ray A, Amato AA, Bradshaw EM, Felice KJ, DiCapua DB, Goldstein JM, Lundberg IE, Nowak RJ, Ploegh HL, Spooner E, Wu Q, Willis SN, O'Connor KC. Autoantibodies produced at the site of tissue damage provide evidence of humoral autoimmunity in inclusion body myositis. Plos One. 7: e46709. PMID 23071619 DOI: 10.1371/journal.pone.0046709  0.68
2012 Dougan SK, Ogata S, Hu CC, Grotenbreg GM, Guillen E, Jaenisch R, Ploegh HL. IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 13739-44. PMID 22869725 DOI: 10.1073/pnas.1210273109  0.68
2012 Sehrawat S, Kirak O, Koenig PA, Isaacson MK, Marques S, Bozkurt G, Simas JP, Jaenisch R, Ploegh HL. CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection. Cell Reports. 1: 461-71. PMID 22832272 DOI: 10.1016/j.celrep.2012.03.009  0.68
2012 Witte MD, Cragnolini JJ, Dougan SK, Yoder NC, Popp MW, Ploegh HL. Preparation of unnatural N-to-N and C-to-C protein fusions. Proceedings of the National Academy of Sciences of the United States of America. 109: 11993-8. PMID 22778432 DOI: 10.1073/pnas.1205427109  0.68
2012 Hess GT, Cragnolini JJ, Popp MW, Allen MA, Dougan SK, Spooner E, Ploegh HL, Belcher AM, Guimaraes CP. M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins. Bioconjugate Chemistry. 23: 1478-87. PMID 22759232 DOI: 10.1021/bc300130z  0.68
2012 Rosmarin DM, Carette JE, Olive AJ, Starnbach MN, Brummelkamp TR, Ploegh HL. Attachment of Chlamydia trachomatis L2 to host cells requires sulfation. Proceedings of the National Academy of Sciences of the United States of America. 109: 10059-64. PMID 22675117 DOI: 10.1073/pnas.1120244109  0.68
2012 Sanyal S, Claessen JH, Ploegh HL. A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells. The Journal of Biological Chemistry. 287: 23594-603. PMID 22619172 DOI: 10.1074/jbc.M112.365312  0.68
2012 Davies CW, Chaney J, Korbel G, Ringe D, Petsko GA, Ploegh H, Das C. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorganic & Medicinal Chemistry Letters. 22: 3900-4. PMID 22617491 DOI: 10.1016/j.bmcl.2012.04.124  0.68
2012 Lehmann SM, Krüger C, Park B, Derkow K, Rosenberger K, Baumgart J, Trimbuch T, Eom G, Hinz M, Kaul D, Habbel P, Kälin R, Franzoni E, Rybak A, Nguyen D, ... ... Ploegh HL, et al. An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration. Nature Neuroscience. 15: 827-35. PMID 22610069 DOI: 10.1038/nn.3113  0.68
2012 Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L. Development of an influenza virus protein array using Sortagging technology. Bioconjugate Chemistry. 23: 1119-26. PMID 22594688 DOI: 10.1021/bc200577u  0.68
2012 Popp MW, Karssemeijer RA, Ploegh HL. Chemoenzymatic site-specific labeling of influenza glycoproteins as a tool to observe virus budding in real time. Plos Pathogens. 8: e1002604. PMID 22457626 DOI: 10.1371/journal.ppat.1002604  0.68
2012 van der Veen AG, Ploegh HL. Ubiquitin-like proteins. Annual Review of Biochemistry. 81: 323-57. PMID 22404627 DOI: 10.1146/annurev-biochem-093010-153308  0.68
2012 Strijbis K, Spooner E, Ploegh HL. Protein ligation in living cells using sortase. Traffic (Copenhagen, Denmark). 13: 780-9. PMID 22348280 DOI: 10.1111/j.1600-0854.2012.01345.x  0.68
2012 Olvera-Gomez I, Hamilton SE, Xiao Z, Guimaraes CP, Ploegh HL, Hogquist KA, Wang L, Jameson SC. Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proceedings of the National Academy of Sciences of the United States of America. 109: 2072-7. PMID 22308317 DOI: 10.1073/pnas.1105771109  0.68
2012 Lee CC, Avalos AM, Ploegh HL. Accessory molecules for Toll-like receptors and their function. Nature Reviews. Immunology. 12: 168-79. PMID 22301850 DOI: 10.1038/nri3151  0.68
2012 Costantino CM, Spooner E, Ploegh HL, Hafler DA. Class II MHC self-antigen presentation in human B and T lymphocytes. Plos One. 7: e29805. PMID 22299025 DOI: 10.1371/journal.pone.0029805  0.68
2012 Claessen JH, Kundrat L, Ploegh HL. Protein quality control in the ER: balancing the ubiquitin checkbook. Trends in Cell Biology. 22: 22-32. PMID 22055166 DOI: 10.1016/j.tcb.2011.09.010  0.68
2012 Ploegh H. Nobel Prize: A dark edge to the glory Nature. 486: 318-319. DOI: 10.1038/486318a  0.68
2011 Claessen JH, Ploegh HL. BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum. Plos One. 6: e28542. PMID 22174835 DOI: 10.1371/journal.pone.0028542  0.68
2011 Guimaraes CP, Carette JE, Varadarajan M, Antos J, Popp MW, Spooner E, Brummelkamp TR, Ploegh HL. Identification of host cell factors required for intoxication through use of modified cholera toxin. The Journal of Cell Biology. 195: 751-64. PMID 22123862 DOI: 10.1083/jcb.201108103  0.68
2011 Smith MH, Ploegh HL, Weissman JS. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (New York, N.Y.). 334: 1086-90. PMID 22116878 DOI: 10.1126/science.1209235  0.68
2011 Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. Plos One. 6: e24434. PMID 21931713 DOI: 10.1371/journal.pone.0024434  0.68
2011 Mashayekhi M, Sandau MM, Dunay IR, Frickel EM, Khan A, Goldszmid RS, Sher A, Ploegh HL, Murphy TL, Sibley LD, Murphy KM. CD8α(+) dendritic cells are the critical source of interleukin-12 that controls acute infection by Toxoplasma gondii tachyzoites. Immunity. 35: 249-59. PMID 21867928 DOI: 10.1016/j.immuni.2011.08.008  0.68
2011 Klemm EJ, Spooner E, Ploegh HL. Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. The Journal of Biological Chemistry. 286: 37602-14. PMID 21857022 DOI: 10.1074/jbc.M111.284794  0.68
2011 Esteban A, Popp MW, Vyas VK, Strijbis K, Ploegh HL, Fink GR. Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 108: 14270-5. PMID 21825168 DOI: 10.1073/pnas.1111415108  0.68
2011 Avalos AM, Ploegh HL. Competition by inhibitory oligonucleotides prevents binding of CpG to C-terminal TLR9. European Journal of Immunology. 41: 2820-7. PMID 21766476 DOI: 10.1002/eji.201141563  0.68
2011 Carette JE, Guimaraes CP, Wuethrich I, Blomen VA, Varadarajan M, Sun C, Bell G, Yuan B, Muellner MK, Nijman SM, Ploegh HL, Brummelkamp TR. Global gene disruption in human cells to assign genes to phenotypes by deep sequencing. Nature Biotechnology. 29: 542-6. PMID 21623355 DOI: 10.1038/nbt.1857  0.68
2011 Buti L, Spooner E, Van der Veen AG, Rappuoli R, Covacci A, Ploegh HL. Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proceedings of the National Academy of Sciences of the United States of America. 108: 9238-43. PMID 21562218 DOI: 10.1073/pnas.1106200108  0.68
2011 Popp MW, Ploegh HL. Making and breaking peptide bonds: protein engineering using sortase. Angewandte Chemie (International Ed. in English). 50: 5024-32. PMID 21538739 DOI: 10.1002/anie.201008267  0.68
2011 McGehee AM, Strijbis K, Guillen E, Eng T, Kirak O, Ploegh HL. Ubiquitin-dependent control of class II MHC localization is dispensable for antigen presentation and antibody production. Plos One. 6: e18817. PMID 21533087 DOI: 10.1371/journal.pone.0018817  0.68
2011 Bolscher JG, Oudhoff MJ, Nazmi K, Antos JM, Guimaraes CP, Spooner E, Haney EF, Garcia Vallejo JJ, Vogel HJ, van't Hof W, Ploegh HL, Veerman EC. Sortase A as a tool for high-yield histatin cyclization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2650-8. PMID 21525488 DOI: 10.1096/fj.11-182212  0.68
2011 Park B, Buti L, Lee S, Matsuwaki T, Spooner E, Brinkmann MM, Nishihara M, Ploegh HL. Granulin is a soluble cofactor for toll-like receptor 9 signaling. Immunity. 34: 505-13. PMID 21497117 DOI: 10.1016/j.immuni.2011.01.018  0.56
2011 Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL. Enzymatic blockade of the ubiquitin-proteasome pathway. Plos Biology. 8: e1000605. PMID 21468303 DOI: 10.1371/journal.pbio.1000605  0.68
2011 Popp MW, Dougan SK, Chuang TY, Spooner E, Ploegh HL. Sortase-catalyzed transformations that improve the properties of cytokines. Proceedings of the National Academy of Sciences of the United States of America. 108: 3169-74. PMID 21297034 DOI: 10.1073/pnas.1016863108  0.68
2011 Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and Cellular Biology. 31: 1145-59. PMID 21220515 DOI: 10.1128/MCB.00967-10  0.68
2011 Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proceedings of the National Academy of Sciences of the United States of America. 108: 1763-70. PMID 21209336 DOI: 10.1073/pnas.1014402108  0.68
2011 Artavanis-Tsakonas K, Kasperkovitz PV, Papa E, Cardenas ML, Khan NS, Van der Veen AG, Ploegh HL, Vyas JM. The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification. Infection and Immunity. 79: 1098-106. PMID 21149584 DOI: 10.1128/IAI.01135-10  0.68
2011 Hoehl MM, Dougan SK, Ploegh HL, Voldman J. Massively parallel microfluidic cell-pairing platform for the statistical study of immunological cell-cell interactions 15th International Conference On Miniaturized Systems For Chemistry and Life Sciences 2011, Microtas 2011. 3: 1508-1510.  0.68
2010 Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Transnuclear mice with pre-defined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Journal of Visualized Experiments : Jove. PMID 20972401 DOI: 10.3791/2168  0.68
2010 Park B, Spooner E, Houser BL, Strominger JL, Ploegh HL. The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation. The Journal of Experimental Medicine. 207: 2033-41. PMID 20713594 DOI: 10.1084/jem.20091793  0.68
2010 Hegde RS, Ploegh HL. Quality and quantity control at the endoplasmic reticulum. Current Opinion in Cell Biology. 22: 437-46. PMID 20570125 DOI: 10.1016/j.ceb.2010.05.005  0.68
2010 Claessen JH, Mueller B, Spooner E, Pivorunas VL, Ploegh HL. The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum. The Journal of Biological Chemistry. 285: 20732-9. PMID 20435896 DOI: 10.1074/jbc.M110.120766  0.68
2010 Kirak O, Frickel EM, Grotenbreg GM, Suh H, Jaenisch R, Ploegh HL. Transnuclear mice with predefined T cell receptor specificities against Toxoplasma gondii obtained via SCNT. Science (New York, N.Y.). 328: 243-8. PMID 20378817 DOI: 10.1126/science.1178590  0.68
2010 Wilson DC, Grotenbreg GM, Liu K, Zhao Y, Frickel EM, Gubbels MJ, Ploegh HL, Yap GS. Differential regulation of effector- and central-memory responses to Toxoplasma gondii Infection by IL-12 revealed by tracking of Tgd057-specific CD8+ T cells. Plos Pathogens. 6: e1000815. PMID 20333242 DOI: 10.1371/journal.ppat.1000815  0.68
2010 Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 140: 704-16. PMID 20211139 DOI: 10.1016/j.cell.2010.01.026  0.68
2010 Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. The Journal of Biological Chemistry. 285: 6857-66. PMID 20042598 DOI: 10.1074/jbc.M109.072405  0.68
2010 Pandya RK, Partridge JR, Love KR, Schwartz TU, Ploegh HL. A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities. The Journal of Biological Chemistry. 285: 5664-73. PMID 20007713 DOI: 10.1074/jbc.M109.051805  0.68
2009 Carette JE, Guimaraes CP, Varadarajan M, Park AS, Wuethrich I, Godarova A, Kotecki M, Cochran BH, Spooner E, Ploegh HL, Brummelkamp TR. Haploid genetic screens in human cells identify host factors used by pathogens. Science (New York, N.Y.). 326: 1231-5. PMID 19965467 DOI: 10.1126/science.1178955  0.68
2009 Ernst R, Mueller B, Ploegh HL, Schlieker C. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Molecular Cell. 36: 28-38. PMID 19818707 DOI: 10.1016/j.molcel.2009.09.016  0.68
2009 Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, Ploegh HL. Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. The Journal of Experimental Medicine. 206: 2429-40. PMID 19808260 DOI: 10.1084/jem.20090782  0.68
2009 McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis. Journal of Immunology (Baltimore, Md. : 1950). 183: 3690-9. PMID 19710472 DOI: 10.4049/jimmunol.0900953  0.68
2009 Gredmark-Russ S, Isaacson MK, Kattenhorn L, Cheung EJ, Watson N, Ploegh HL. A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection. Journal of Virology. 83: 10644-52. PMID 19706716 DOI: 10.1128/JVI.01017-09  0.68
2009 Antos JM, Chew GL, Guimaraes CP, Yoder NC, Grotenbreg GM, Popp MW, Ploegh HL. Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity. Journal of the American Chemical Society. 131: 10800-1. PMID 19610623 DOI: 10.1021/ja902681k  0.68
2009 Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 945-52. PMID 19553543 DOI: 10.4049/jimmunol.0900921  0.68
2009 Isaacson MK, Ploegh HL. Ubiquitination, ubiquitin-like modifiers, and deubiquitination in viral infection. Cell Host & Microbe. 5: 559-70. PMID 19527883 DOI: 10.1016/j.chom.2009.05.012  0.68
2009 Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. The Embo Journal. 28: 1624-36. PMID 19407814 DOI: 10.1038/emboj.2009.117  0.68
2009 Popp MW, Antos JM, Ploegh HL. Site-specific protein labeling via sortase-mediated transpeptidation. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 15.3. PMID 19365788 DOI: 10.1002/0471140864.ps1503s56  0.68
2009 Antos JM, Popp MW, Ernst R, Chew GL, Spooner E, Ploegh HL. A straight path to circular proteins. The Journal of Biological Chemistry. 284: 16028-36. PMID 19359246 DOI: 10.1074/jbc.M901752200  0.68
2009 Love KR, Pandya RK, Spooner E, Ploegh HL. Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery Acs Chemical Biology. 4: 275-287. PMID 19256548 DOI: 10.1021/cb9000348  0.68
2009 Popp MW, Artavanis-Tsakonas K, Ploegh HL. Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations Journal of Biological Chemistry. 284: 3593-3602. PMID 19047059 DOI: 10.1074/jbc.M807172200  0.68
2008 Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proceedings of the National Academy of Sciences of the United States of America. 105: 18255-60. PMID 19017811 DOI: 10.1073/pnas.0808756105  0.68
2008 Story CM, Papa E, Hu CC, Ronan JL, Herlihy K, Ploegh HL, Love JC. Profiling antibody responses by multiparametric analysis of primary B cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 17902-7. PMID 19004776 DOI: 10.1073/pnas.0805470105  0.68
2008 Antos JM, Miller GM, Grotenbreg GM, Ploegh HL. Lipid modification of proteins through sortase-catalyzed transpeptidation. Journal of the American Chemical Society. 130: 16338-43. PMID 18989959 DOI: 10.1021/ja806779e  0.68
2008 Park B, Brinkmann MM, Spooner E, Lee CC, Kim YM, Ploegh HL. Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 Nature Immunology. 9: 1407-1414. PMID 18931679 DOI: 10.1038/ni.1669  0.68
2008 Gredmark-Russ S, Cheung EJ, Isaacson MK, Ploegh HL, Grotenbreg GM. The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens. Journal of Virology. 82: 12205-12. PMID 18922872 DOI: 10.1128/JVI.01463-08  0.68
2008 Frickel EM, Sahoo N, Hopp J, Gubbels MJ, Craver MP, Knoll LJ, Ploegh HL, Grotenbreg GM. Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. The Journal of Infectious Diseases. 198: 1625-33. PMID 18922097 DOI: 10.1086/593019  0.68
2008 Walters BJ, Campbell SL, Chen PC, Taylor AP, Schroeder DG, Dobrunz LE, Artavanis-Tsakonas K, Ploegh HL, Wilson JA, Cox GA, Wilson SM. Differential effects of Usp14 and Uch-L1 on the ubiquitin proteasome system and synaptic activity. Molecular and Cellular Neurosciences. 39: 539-48. PMID 18771733 DOI: 10.1016/j.mcn.2008.07.028  0.68
2008 Mueller B, Klemm EJ, Spooner E, Claessen JH, Ploegh HL. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins Proceedings of the National Academy of Sciences of the United States of America. 105: 12325-12330. PMID 18711132 DOI: 10.1073/pnas.0805371105  0.68
2008 Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clinical Immunology (Orlando, Fla.). 129: 10-8. PMID 18675591 DOI: 10.1016/j.clim.2008.06.009  0.68
2008 Vyas JM, Van Der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation Nature Reviews Immunology. 8: 607-618. PMID 18641646 DOI: 10.1038/nri2368  0.68
2008 Kim YM, Brinkmann MM, Paquet ME, Ploegh HL. UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes. Nature. 452: 234-8. PMID 18305481 DOI: 10.1038/nature06726  0.68
2008 Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. Journal of Immunology (Baltimore, Md. : 1950). 180: 2876-85. PMID 18292509  0.68
2008 Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL. Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proceedings of the National Academy of Sciences of the United States of America. 105: 3831-6. PMID 18245382 DOI: 10.1073/pnas.0711504105  0.68
2008 Kario E, Tirosh B, Ploegh HL, Navon A. N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation Journal of Biological Chemistry. 283: 244-254. PMID 17951257 DOI: 10.1074/jbc.M706237200  0.68
2008 Ovaa H, Overkleeft HS, Kessler BM, Ploegh HL. Dissecting Intracellular Proteolysis Using Small Molecule Inhibitors and Molecular Probes Protein Degradation. 2: 51-78. DOI: 10.1002/9783527620210.ch3  0.68
2007 Ploegh HL. Bridging B cell and T cell recognition of antigen Journal of Immunology. 179: 7193. PMID 18025158  0.68
2007 Love KR, Catic A, Schlieker C, Ploegh HL. Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nature Chemical Biology. 3: 697-705. PMID 17948018 DOI: 10.1038/nchembio.2007.43  0.68
2007 Popp MW, Antos JM, Grotenbreg GM, Spooner E, Ploegh HL. Sortagging: a versatile method for protein labeling. Nature Chemical Biology. 3: 707-8. PMID 17891153 DOI: 10.1038/nchembio.2007.31  0.68
2007 Ploegh HL. The peptide cargo of class I molecules: Not just passive passengers Journal of Immunology. 179: 4299-4300. PMID 17878322  0.68
2007 Derkow K, Loddenkemper C, Mintern J, Kruse N, Klugewitz K, Berg T, Wiedenmann B, Ploegh HL, Schott E. Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis Hepatology. 46: 1155-1165. PMID 17657820 DOI: 10.1002/hep.21796  0.68
2007 Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, Ploegh HL. Screen for ISG15-crossreactive deubiquitinases. Plos One. 2: e679. PMID 17653289 DOI: 10.1371/journal.pone.0000679  0.68
2007 Ploegh HL. A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum Nature. 448: 435-438. PMID 17653186 DOI: 10.1038/nature06004  0.68
2007 Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL. A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection. Journal of Virology. 81: 10300-9. PMID 17634221 DOI: 10.1128/JVI.01149-07  0.68
2007 Catic A, Sun ZY, Ratner DM, Misaghi S, Spooner E, Samuelson J, Wagner G, Ploegh HL. Sequence and structure evolved separately in a ribosomal ubiquitin variant. The Embo Journal. 26: 3474-83. PMID 17599068 DOI: 10.1038/sj.emboj.7601772  0.68
2007 Kim YM, Brinkmann MM, Ploegh HL. TLRs bent into shape Nature Immunology. 8: 675-677. PMID 17579642 DOI: 10.1038/ni0707-675  0.68
2007 Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, Wucherpfennig KW. Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. The Journal of Biological Chemistry. 282: 21425-36. PMID 17525157 DOI: 10.1074/jbc.M702844200  0.68
2007 Vyas JM, Kim YM, Artavanis-Tsakonas K, Love JC, Van der Veen AG, Ploegh HL. Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 7199-210. PMID 17513769  0.68
2007 Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, Kopito RR. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. The Embo Journal. 26: 2693-706. PMID 17491588 DOI: 10.1038/sj.emboj.7601722  0.68
2007 Brinkmann MM, Spooner E, Hoebe K, Beutler B, Ploegh HL, Kim YM. The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling Journal of Cell Biology. 177: 265-275. PMID 17452530 DOI: 10.1083/jcb.200612056  0.68
2007 Catic A, Misaghi S, Korbel GA, Ploegh HL. ElaD, a Deubiquitinating protease expressed by E. coli. Plos One. 2: e381. PMID 17440617 DOI: 10.1371/journal.pone.0000381  0.68
2007 Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Molecular Cell. 25: 677-87. PMID 17349955 DOI: 10.1016/j.molcel.2007.01.033  0.68
2007 Hang HC, Geutjes EJ, Grotenbreg G, Pollington AM, Bijlmakers MJ, Ploegh HL. Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. Journal of the American Chemical Society. 129: 2744-5. PMID 17305342 DOI: 10.1021/ja0685001  0.68
2007 Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL. AID-/-μs-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells Journal of Immunology. 178: 2192-2203. PMID 17277124  0.68
2007 Gewurz BE, Vyas JM, Ploegh HL. Herpesvirus evasion of T-Cell immunity Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. 1117-1136. DOI: 10.1017/CBO9780511545313.063  0.68
2006 Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. Acs Chemical Biology. 1: 713-23. PMID 17184136 DOI: 10.1021/cb600431a  0.68
2006 Loureiro J, Ploegh HL. Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions Advances in Immunology. 92: 225-305. PMID 17145306 DOI: 10.1016/S0065-2776(06)92006-9  0.68
2006 Mintern JD, Klemm EJ, Wagner M, Paquet ME, Napier MD, Kim YM, Koszinowski UH, Ploegh HL. Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1. Journal of Immunology (Baltimore, Md. : 1950). 177: 8422-31. PMID 17142739  0.68
2006 Artavanis-Tsakonas K, Love JC, Ploegh HL, Vyas JM. Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proceedings of the National Academy of Sciences of the United States of America. 103: 15945-50. PMID 17043215 DOI: 10.1073/pnas.0607528103  0.68
2006 Mueller B, Lilley BN, Ploegh HL. SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. The Journal of Cell Biology. 175: 261-70. PMID 17043138 DOI: 10.1083/jcb.200605196  0.68
2006 Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum Molecular Microbiology. 61: 1187-1195. PMID 16925553 DOI: 10.1111/j.1365-2958.2006.05307.x  0.68
2006 Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL. Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. Journal of Virology. 80: 8739-44. PMID 16912321 DOI: 10.1128/JVI.00791-06  0.68
2006 Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: Major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines Immunology. 119: 98-115. PMID 16836618 DOI: 10.1111/j.1365-2567.2006.02412.x  0.68
2006 Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection Molecular Microbiology. 61: 142-150. PMID 16824101 DOI: 10.1111/j.1365-2958.2006.05199.x  0.68
2006 Vishwanath M, Nishibu A, Saeland S, Ward BR, Mizumoto N, Ploegh HL, Boes M, Takashima A. Development of intravital intermittent confocal imaging system for studying Langerhans cell turnover Journal of Investigative Dermatology. 126: 2452-2457. PMID 16794586 DOI: 10.1038/sj.jid.5700448  0.68
2006 Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, Ploegh HL. Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature. 441: 894-7. PMID 16738546 DOI: 10.1038/nature04830  0.68
2006 Wang J, Loveland AN, Kattenhorn LM, Ploegh HL, Gibson W. High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. Journal of Virology. 80: 6003-12. PMID 16731939 DOI: 10.1128/JVI.00401-06  0.68
2006 Love JC, Ronan JL, Grotenbreg GM, van der Veen AG, Ploegh HL. A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nature Biotechnology. 24: 703-7. PMID 16699501 DOI: 10.1038/nbt1210  0.68
2006 Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nature Cell Biology. 8: 339-47. PMID 16531995 DOI: 10.1038/ncb1378  0.68
2006 Groll M, Berkers CR, Ploegh HL, Ovaa H. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome Structure. 14: 451-456. PMID 16531229 DOI: 10.1016/j.str.2005.11.019  0.68
2006 Kim YM, Pan JY, Korbel GA, Peperzak V, Boes M, Ploegh HL. Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. Proceedings of the National Academy of Sciences of the United States of America. 103: 3327-32. PMID 16492756 DOI: 10.1073/pnas.0511315103  0.68
2006 Nishibu A, Ward BR, Jester JV, Ploegh HL, Boes M, Takashima A. Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli Journal of Investigative Dermatology. 126: 787-796. PMID 16439974 DOI: 10.1038/sj.jid.5700107  0.68
2006 Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response Journal of Biological Chemistry. 281: 5852-5860. PMID 16332684 DOI: 10.1074/jbc.M509061200  0.68
2006 Misaghi S, Korbel GA, Kessler B, Spooner E, Ploegh HL. z-VAD-fmk inhibits peptide:N-glycanase and may result in ER stress. Cell Death and Differentiation. 13: 163-5. PMID 16003388 DOI: 10.1038/sj.cdd.4401716  0.68
2006 Risseeuw MDP, Berkers CR, Ploegh HL, Ovaa H. Synthesis of tritium labeled KRN7000 Tetrahedron Letters. 47: 3677-3679. DOI: 10.1016/j.tetlet.2006.03.131  0.68
2006 Ploegh HL. Dislocation and degradation of proteins from the endoplasmic reticulum: Preface Current Topics in Microbiology and Immunology. 300: V-VII.  0.68
2005 Ovaa H, Galardy PJ, Ploegh HL. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Synthesis of active site-directed probes Methods in Enzymology. 399: 468-478. PMID 16338376 DOI: 10.1016/S0076-6879(05)99032-0  0.68
2005 Galardy P, Ploegh HL, Ovaa H. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Crystallography, activity profiling, and protease identification Methods in Enzymology. 399: 120-131. PMID 16338352 DOI: 10.1016/S0076-6879(05)99008-3  0.68
2005 Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL. A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. Journal of Virology. 79: 15582-5. PMID 16306630 DOI: 10.1128/JVI.79.24.15582-15585.2005  0.68
2005 Anderson C, Crimmins S, Wilson JA, Korbel GA, Ploegh HL, Wilson SM. Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice. Journal of Neurochemistry. 95: 724-31. PMID 16190881 DOI: 10.1111/j.1471-4159.2005.03409.x  0.68
2005 Lilley BN, Ploegh HL. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proceedings of the National Academy of Sciences of the United States of America. 102: 14296-301. PMID 16186509 DOI: 10.1073/pnas.0505014102  0.68
2005 Catic A, Ploegh HL. Ubiquitin - Conserved protein or selfish gene? Trends in Biochemical Sciences. 30: 600-604. PMID 16185873 DOI: 10.1016/j.tibs.2005.09.002  0.68
2005 Maehr R, Mintern JD, Herman AE, Lennon-Duménil AM, Mathis D, Benoist C, Ploegh HL. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. The Journal of Clinical Investigation. 115: 2934-43. PMID 16184198 DOI: 10.1172/JCI25485  0.68
2005 Lilley BN, Ploegh HL. Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunological Reviews. 207: 126-44. PMID 16181332 DOI: 10.1111/j.0105-2896.2005.00318.x  0.68
2005 Altun M, Galardy PJ, Shringarpure R, Hideshima T, LeBlanc R, Anderson KC, Ploegh HL, Kessler BM. Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells Cancer Research. 65: 7896-7901. PMID 16140960 DOI: 10.1158/0008-5472.CAN-05-0506  0.68
2005 Kattenhorn LM, Korbel GA, Kessler BM, Spooner E, Ploegh HL. A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Molecular Cell. 19: 547-57. PMID 16109378 DOI: 10.1016/j.molcel.2005.07.003  0.68
2005 Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells Journal of Experimental Medicine. 202: 505-516. PMID 16103408 DOI: 10.1084/jem.20050575  0.68
2005 Ploegh HL. A molecule's right to choose: How diabetogenic class II MHC products bind peptides Journal of Clinical Investigation. 115: 2077-2079. PMID 16075053 DOI: 10.1172/JCI26018  0.68
2005 Guerra L, Teter K, Lilley BN, Stenerlöw B, Holmes RK, Ploegh HL, Sandvig K, Thelestam M, Frisan T. Cellular internalization of cytolethal distending toxin: a new end to a known pathway. Cellular Microbiology. 7: 921-34. PMID 15953025 DOI: 10.1111/j.1462-5822.2005.00520.x  0.68
2005 Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL. Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. Journal of Immunology (Baltimore, Md. : 1950). 174: 7066-74. PMID 15905550  0.68
2005 Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib Nature Methods. 2: 357-362. PMID 15846363 DOI: 10.1038/nmeth759  0.68
2005 Tirosh B, Iwakoshi NN, Lilley BN, Lee AH, Glimcher LH, Ploegh HL. Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. Journal of Virology. 79: 2768-79. PMID 15708995 DOI: 10.1128/JVI.79.5.2768-2779.2005  0.68
2005 Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance Science. 307: 254-258. PMID 15653504 DOI: 10.1126/science.1102901  0.68
2005 Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European Journal of Chemical Biology. 6: 287-91. PMID 15651044 DOI: 10.1002/cbic.200400236  0.68
2005 Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcεRI controls the formation of functional IgE-binding receptors Journal of Experimental Medicine. 201: 267-277. PMID 15642744 DOI: 10.1084/jem.20041384  0.68
2005 Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. The Journal of Biological Chemistry. 280: 1512-20. PMID 15531586 DOI: 10.1074/jbc.M410770200  0.68
2004 van Swieten PF, Maehr R, van den Nieuwendijk AM, Kessler BM, Reich M, Wong CS, Kalbacher H, Leeuwenburgh MA, Driessen C, van der Marel GA, Ploegh HL, Overkleeft HS. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 14: 3131-4. PMID 15149659 DOI: 10.1016/j.bmcl.2004.04.046  0.44
2003 Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Molecular & Cellular Proteomics : McP. 2: 1188-97. PMID 13130081 DOI: 10.1074/mcp.M300067-MCP200  0.44
2003 Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angewandte Chemie (International Ed. in English). 42: 3626-9. PMID 12916032 DOI: 10.1002/anie.200351314  0.44
2003 Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. The Journal of Biological Chemistry. 278: 35869-77. PMID 12815064 DOI: 10.1074/jbc.M303725200  0.44
2002 Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. The Journal of Experimental Medicine. 196: 529-40. PMID 12186844  0.44
2001 Borodovsky A, Kessler BM, Casagrande R, Overkleeft HS, Wilkinson KD, Ploegh HL. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. The Embo Journal. 20: 5187-96. PMID 11566882 DOI: 10.1093/emboj/20.18.5187  0.44
2001 Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chemistry & Biology. 8: 913-29. PMID 11564559  0.44
2001 Lennon-Duménil AM, Roberts RA, Valentijn K, Driessen C, Overkleeft HS, Erickson A, Peters PJ, Bikoff E, Ploegh HL, Wolf Bryant P. The p41 isoform of invariant chain is a chaperone for cathepsin L. The Embo Journal. 20: 4055-64. PMID 11483509 DOI: 10.1093/emboj/20.15.4055  0.44
1995 Peters PJ, Raposo G, Neefjes JJ, Oorschot V, Leijendekker RL, Geuze HJ, Ploegh HL. Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes. The Journal of Experimental Medicine. 182: 325-34. PMID 7629497 DOI: 10.1084/jem.182.2.325  0.68
1993 Bijlmakers MJ, Neefjes JJ, Wojcik-Jacobs EH, Ploegh HL. The assembly of H2-Kb class I molecules translated in vitro requires oxidized glutathione and peptide. European Journal of Immunology. 23: 1305-13. PMID 8500526 DOI: 10.1002/eji.1830230618  0.8
1993 Neefjes JJ, Dierx J, Ploegh HL. The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions. European Journal of Immunology. 23: 840-5. PMID 8384560 DOI: 10.1002/eji.1830230411  0.8
1992 Neefjes JJ, Ploegh HL. Intracellular transport of MHC class II molecules. Immunology Today. 13: 179-84. PMID 1642756 DOI: 10.1016/0167-5699(92)90123-O  0.8
1992 Faber ED, Oosting R, Neefjes JJ, Ploegh HL, Meijer DK. Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo. Pharmaceutical Research. 9: 1442-50. PMID 1475231  0.8
1992 Neefjes JJ, Smit L, Gehrmann M, Ploegh HL. The fate of the three subunits of major histocompatibility complex class I molecules. European Journal of Immunology. 22: 1609-14. PMID 1318200 DOI: 10.1002/eji.1830220639  0.68
1992 Neefjes JJ, Ploegh HL. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. The Embo Journal. 11: 411-6. PMID 1311249  0.8
1991 Peters PJ, Neefjes JJ, Oorschot V, Ploegh HL, Geuze HJ. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature. 349: 669-76. PMID 1847504 DOI: 10.1038/349669a0  0.8
1991 Neefjes JJ, Schumacher TN, Ploegh HL. Assembly and intracellular transport of major histocompatibility complex molecules. Current Opinion in Cell Biology. 3: 601-9. PMID 1837724  0.8
1991 Schumacher TN, De Bruijn ML, Vernie LN, Kast WM, Melief CJ, Neefjes JJ, Ploegh HL. Peptide selection by MHC class I molecules. Nature. 350: 703-6. PMID 1708852 DOI: 10.1038/350703a0  0.68
1990 Neefjes JJ, De Bruijn ML, Boog CJ, Nieland JD, Boes J, Melief CJ, Ploegh HL. N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response. The Journal of Experimental Medicine. 171: 583-8. PMID 2303788  0.8
1990 Neefjes JJ, Hengeveld T, Tol O, Ploegh HL. Intracellular interactions of transferrin and its receptor during biosynthesis. The Journal of Cell Biology. 111: 1383-92. PMID 2211816  0.8
1990 Schumacher TN, Heemels MT, Neefjes JJ, Kast WM, Melief CJ, Ploegh HL. Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell. 62: 563-7. PMID 2199065 DOI: 10.1016/0092-8674(90)90020-F  0.68
1990 Neefjes JJ, Stollorz V, Peters PJ, Geuze HJ, Ploegh HL. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell. 61: 171-83. PMID 2156628  0.8
1989 Boog CJ, Neefjes JJ, Boes J, Ploegh HL, Melief CJ. Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells. European Journal of Immunology. 19: 537-42. PMID 2785048 DOI: 10.1002/eji.1830190319  0.68
1989 Masucci MG, Stam NJ, Torsteinsdottir S, Neefjes JJ, Klein G, Ploegh HL. Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines. Cellular Immunology. 120: 396-400. PMID 2541930  0.8
1989 Neefjes JJ, Lindhout J, Broxterman HJ, van der Marel GA, van Boom JH, Ploegh HL. Non-carrier-mediated uptake of the mannosidase I inhibitor 1-deoxymannojirimycin by K562 erythroleukemic cells. The Journal of Biological Chemistry. 264: 10271-5. PMID 2524494  0.8
1989 Doxiadis I, Krumbacher K, Neefjes JJ, Ploegh HL, Grosse-Wilde H. Biochemical evidence that the DLA-B locus codes for a class II determinant expressed on all canine peripheral blood lymphocytes. Experimental and Clinical Immunogenetics. 6: 219-24. PMID 2520676  0.8
1989 Rotteveel FT, Neefjes JJ, Ploegh HL, Lucas CJ. Influenza virus changes cell-surface glycoproteins including major histocompatibility complex determinants on lymphocytes. Human Immunology. 26: 199-213. PMID 2514159  0.8
1988 Bolscher JG, van der Bijl MM, Neefjes JJ, Hall A, Smets LA, Ploegh HL. Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential. The Embo Journal. 7: 3361-8. PMID 3061796  0.8
1988 Neefjes JJ, Ploegh HL. Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association. European Journal of Immunology. 18: 801-10. PMID 2967765 DOI: 10.1002/eji.1830180522  0.8
1988 Neefjes JJ, Verkerk JM, Broxterman HJ, van der Marel GA, van Boom JH, Ploegh HL. Recycling glycoproteins do not return to the cis-Golgi. The Journal of Cell Biology. 107: 79-87. PMID 2839522  0.8
1987 Rein RS, Seemann GH, Neefjes JJ, Hochstenbach FM, Stam NJ, Ploegh HL. Association with beta 2-microglobulin controls the expression of transfected human class I genes. Journal of Immunology (Baltimore, Md. : 1950). 138: 1178-83. PMID 3543123  0.8
1987 Gruters RA, Neefjes JJ, Tersmette M, de Goede RE, Tulp A, Huisman HG, Miedema F, Ploegh HL. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature. 330: 74-7. PMID 2959866 DOI: 10.1038/330074a0  0.8
1986 Neefjes JJ, Doxiadis I, Stam NJ, Beckers CJ, Ploegh HL. An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting. Immunogenetics. 23: 164-71. PMID 3957414  0.8
1986 Neefjes JJ, Hensen EJ, de Kroon TI, Ploegh HL. A biochemical characterization of feline MHC products: unusually high expression of class II antigens on peripheral blood lymphocytes. Immunogenetics. 23: 341-7. PMID 3458670  0.8
1986 Neefjes JJ, Breur-Vriesendorp BS, van Seventer GA, Iványi P, Ploegh HL. An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes. Human Immunology. 16: 169-81. PMID 3087921  0.8
1983 Vasilov RG, Hahn A, Mölders H, van Rood JJ, Breuning M, Ploegh HL. Analysis of human class I antigens by two-dimensional gel electrophoresis. I. Polymorphism, evidence for additional (non-HLA-A, B, C) gene products, and identification of variant HLA-A, B antigens. Immunogenetics. 17: 333-56. PMID 6187677  0.32
1982 Orr HT, Bach FH, Ploegh HL, Strominger JL, Kavathas P, DeMars R. Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex. Nature. 296: 454-6. PMID 7063041 DOI: 10.1038/296454a0  0.68
1981 Ploegh HL, Orr HT, Strominger JL. Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules. Cell. 24: 287-99. PMID 7016338 DOI: 10.1016/0092-8674(81)90318-4  0.68
1980 Strominger JL, Engelhard VH, Guild BC, Kostyk TG, Lancet D, Lopez de Castro JA, Orr HT, Parham P, Ploegh HL, Pober JS. Complete primary structure of human histocompatibility antigen HLA-B7: evolutionary and functional implications. Current Topics in Developmental Biology. 14: 97-113. PMID 7460613 DOI: 10.1016/S0070-2153(08)60190-8  0.68
1980 Strominger JL, Orr HT, Parham P, Ploegh HL, Mann DL, Bilofsky H, Saroff HA, Wu TT, Kabat EA. An evaluation of the significance of amino acid sequence homologies in human histocompatibility antigens (HLA-A and HLA-B) with immunoglobulins and other proteins, using relatively short sequences. Scandinavian Journal of Immunology. 11: 573-92. PMID 7444380  0.32
1980 Korman AJ, Ploegh HL, Kaufman JF, Owen MJ, Strominger JL. Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens. The Journal of Experimental Medicine. 152: 65s-82s. PMID 6967942  0.56
1980 Ploegh HL, Orr HT, Strominger JL. Molecular cloning of a human histocompatibility antigen cDNA fragment. Proceedings of the National Academy of Sciences of the United States of America. 77: 6081-5. PMID 6934534  0.68
1979 Ploegh HL, Cannon LE, Strominger JL. Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens. Proceedings of the National Academy of Sciences of the United States of America. 76: 2273-7. PMID 287067  0.56
1979 Orr HT, Lopez de Castro JA, Parham P, Ploegh HL, Strominger JL. Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proceedings of the National Academy of Sciences of the United States of America. 76: 4395-9. PMID 92029  0.32
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