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Year Citation  Score
2022 Pishesha N, Harmand TJ, Ploegh HL. A guide to antigen processing and presentation. Nature Reviews. Immunology. PMID 35418563 DOI: 10.1038/s41577-022-00707-2  0.303
2021 McCaul N, Porter CM, Becker A, Tang CA, Wijne C, Chatterjee B, Bousbaine D, Bilate A, Hu CA, Ploegh H, Truttmann MC. Deletion of mFICD AMPylase alters cytokine secretion and affects visual short-term learning in vivo. The Journal of Biological Chemistry. 100991. PMID 34419450 DOI: 10.1016/j.jbc.2021.100991  0.726
2020 Woodham AW, Zeigler SH, Zeyang EL, Kolifrath SC, Cheloha RW, Rashidian M, Chaparro RJ, Seidel RD, Garforth SJ, Dearling JL, Mesyngier M, Duddempudi PK, Packard AB, Almo SC, Ploegh HL. In vivo detection of antigen-specific CD8 T cells by immuno-positron emission tomography. Nature Methods. PMID 32929269 DOI: 10.1038/S41592-020-0934-5  0.36
2020 Kato Y, Steiner TM, Park HY, Hitchcock RO, Zaid A, Hor JL, Devi S, Davey GM, Vremec D, Tullett KM, Tan PS, Ahmet F, Mueller SN, Alonso S, Tarlinton DM, ... Ploegh HL, et al. Display of Native Antigen on cDC1 That Have Spatial Access to Both T and B Cells Underlies Efficient Humoral Vaccination. Journal of Immunology (Baltimore, Md. : 1950). PMID 32839238 DOI: 10.4049/Jimmunol.2000549  0.336
2020 Fieulaine S, Witte MD, Theile CS, Ayach M, Ploegh HL, Jupin I, Bressanelli S. protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity. The Journal of Biological Chemistry. PMID 32732284 DOI: 10.1074/Jbc.Ra120.014628  0.319
2020 Cheloha RW, Fischer FA, Woodham AW, Daley E, Suminski N, Gardella TJ, Ploegh HL. Improved GPCR ligands from nanobody tethering. Nature Communications. 11: 2087. PMID 32350260 DOI: 10.1038/S41467-020-15884-8  0.345
2020 Xie YJ, Dougan M, Ingram JR, Pishesha N, Fang T, Momin N, Ploegh HL. Improved anti-tumor efficacy of chimeric antigen receptor T cells that secrete single-domain antibody fragments. Cancer Immunology Research. PMID 32019780 DOI: 10.1158/2326-6066.Cir-19-0734  0.33
2020 Crowley SJ, Bruck PT, Bhuiyan MA, Mitchell-Gears A, Walsh MJ, Zhangxu K, Ali LR, Jeong HJ, Ingram JR, Knipe DM, Ploegh HL, Dougan M, Dougan SK. Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH. Open Biology. 10: 190235. PMID 32019478 DOI: 10.1098/Rsob.190235  0.36
2020 Neefjes J, Overkleeft H, Ploegh H, Schulman B. Huib Ovaa (1973–2020) Chemistry & Biology. 27: 645-646. DOI: 10.1016/J.Chembiol.2020.06.003  0.427
2019 Rehm FBH, Harmand TJ, Yap K, Durek T, Craik DJ, Ploegh HL. Site-specific sequential protein labeling catalyzed by a single recombinant ligase. Journal of the American Chemical Society. PMID 31573802 DOI: 10.1021/Jacs.9B09166  0.348
2019 Ling J, Cheloha RW, McCaul N, Sun ZJ, Wagner G, Ploegh HL. A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity. Molecular Immunology. 114: 513-523. PMID 31518855 DOI: 10.1016/J.Molimm.2019.08.008  0.365
2019 Cheloha RW, Woodham AW, Bousbaine D, Wang T, Liu S, Sidney J, Sette A, Gellman SH, Ploegh HL. Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids. Journal of Immunology (Baltimore, Md. : 1950). PMID 31391235 DOI: 10.4049/Jimmunol.1900536  0.355
2019 Cheloha RW, Li Z, Bousbaine D, Woodham AW, Perrin P, Volarić J, Ploegh HL. Internalization of Influenza Virus and Cell Surface Proteins Monitored by Site-Specific Conjugation of Protease-Sensitive Probes. Acs Chemical Biology. PMID 31348637 DOI: 10.1021/Acschembio.9B00493  0.376
2019 Cheloha RW, Li Z, Bousbaine D, Woodham A, Perrin P, Volaric J, Ploegh HL. Abstract B149: Real-time analysis of cell membrane protein and virus internalization using site-specific conjugation of protease-sensitive probes Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B149  0.393
2018 Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, ... ... Ploegh HL, et al. Protection of tissue physicochemical properties using polyfunctional crosslinkers. Nature Biotechnology. PMID 30556815 DOI: 10.1038/Nbt.4281  0.731
2018 Yang YS, Moynihan KD, Bekdemir A, Dichwalkar TM, Noh MM, Watson N, Melo M, Ingram J, Suh H, Ploegh H, Stellacci FR, Irvine DJ. Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles. Biomaterials Science. PMID 30444251 DOI: 10.1039/C8Bm01208C  0.322
2018 Kaur M, Kumar D, Butty V, Singh S, Esteban A, Fink GR, Ploegh HL, Sehrawat S. Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity. Iscience. 9: 101-119. PMID 30388704 DOI: 10.1016/J.Isci.2018.10.013  0.346
2018 Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL. Targeted delivery of cyclotides via conjugation to a nanobody. Acs Chemical Biology. PMID 30248263 DOI: 10.1021/Acschembio.8B00653  0.359
2018 Harmand T, Bousbaine D, Chan AI, Zhang X, Liu DR, Tam JP, Ploegh HL. One-pot dual labeling of an IgG 1 and preparation of C-to-C fusion proteins through a combination of Sortase A and Butelase 1. Bioconjugate Chemistry. PMID 30231608 DOI: 10.1021/Acs.Bioconjchem.8B00563  0.356
2018 Pishesha N, Ingram JR, Ploegh HL. Sortase A: A Model for Transpeptidation and Its Biological Applications. Annual Review of Cell and Developmental Biology. PMID 30110557 DOI: 10.1146/Annurev-Cellbio-100617-062527  0.36
2018 Bartels L, Ploegh HL, Spits H, Wagner K. Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation. Methods (San Diego, Calif.). PMID 30081077 DOI: 10.1016/J.Ymeth.2018.07.013  0.301
2018 Woodham AW, Cheloha RW, Ling J, Rashidian M, Kolifrath SC, Mesyngier M, Duarte JN, Bader JM, Skeate JG, Da Silva DM, Kast WM, Ploegh HL. Nanobody-antigen conjugates elicit HPV-specific anti-tumor immune responses. Cancer Immunology Research. PMID 29792298 DOI: 10.1158/2326-6066.Cir-17-0661  0.322
2018 Truttmann MC, Pincus D, Ploegh HL. Chaperone AMPylation modulates aggregation and toxicity of neurodegenerative disease-associated polypeptides. Proceedings of the National Academy of Sciences of the United States of America. PMID 29760078 DOI: 10.1073/Pnas.1801989115  0.731
2018 Tang CA, Chang S, Paton AW, Paton JC, Gabrilovich DI, Ploegh HL, Del Valle JR, Hu CA. Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization. The Journal of Cell Biology. PMID 29511123 DOI: 10.1083/Jcb.201709137  0.315
2018 Ingram JR, Schmidt FI, Ploegh HL. Exploiting Nanobodies' Singular Traits. Annual Review of Immunology. PMID 29490163 DOI: 10.1146/Annurev-Immunol-042617-053327  0.306
2018 Pichugin A, Zarling S, Perazzo L, Duffy PE, Ploegh HL, Krzych U. Identification of a Novel CD8 T Cell Epitope Derived fromProtective Liver-Stage Antigen. Frontiers in Immunology. 9: 91. PMID 29434602 DOI: 10.3389/Fimmu.2018.00091  0.383
2018 Ploegh H. Machinery that guides immunity. Nature. 551: 442-443. PMID 29168814 DOI: 10.1038/D41586-017-07268-8  0.307
2017 Bachran C, Schröder M, Conrad L, Cragnolini JJ, Tafesse FG, Helming L, Ploegh HL, Swee LK. The activity of myeloid cell-specific VHH immunotoxins is target-, epitope-, subset- and organ dependent. Scientific Reports. 7: 17916. PMID 29263417 DOI: 10.1038/S41598-017-17948-0  0.365
2017 Truttmann MC, Ploegh HL. In vitro AMPylation Assays Using Purified, Recombinant Proteins. Bio-Protocol. 7. PMID 29170749 DOI: 10.21769/BioProtoc.2416  0.697
2017 Fang T, Van Elssen CHMJ, Duarte JN, Guzman JS, Chahal JS, Ling J, Ploegh HL. Targeted antigen delivery by an anti-class II MHC VHH elicits focused αMUC1(Tn) immunity. Chemical Science. 8: 5591-5597. PMID 28970938 DOI: 10.1039/C7Sc00446J  0.372
2017 Antos JM, Ingram J, Fang T, Pishesha N, Truttmann MC, Ploegh HL. Site-Specific Protein Labeling via Sortase-Mediated Transpeptidation. Current Protocols in Protein Science. 89: 15.3.1-15.3.19. PMID 28762490 DOI: 10.1002/cpps.38  0.741
2017 Clancy-Thompson E, Chen GZ, Tyler PM, Servos MM, Barisa M, Brennan PJ, Ploegh HL, Dougan SK. Monoclonal Invariant NKT (iNKT) Cell Mice Reveal a Role for Both Tissue of Origin and the TCR in Development of iNKT Functional Subsets. Journal of Immunology (Baltimore, Md. : 1950). PMID 28576977 DOI: 10.4049/Jimmunol.1700214  0.302
2017 Truttmann MC, Ploegh HL. rAMPing Up Stress Signaling: Protein AMPylation in Metazoans. Trends in Cell Biology. PMID 28433487 DOI: 10.1016/J.Tcb.2017.03.004  0.751
2017 Hanke L, Schmidt FI, Knockenhauer KE, Morin B, Whelan SP, Schwartz TU, Ploegh HL. Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication. Embo Reports. PMID 28396572 DOI: 10.15252/Embr.201643764  0.303
2017 Pishesha N, Bilate AM, Wibowo MC, Huang NJ, Li Z, Dhesycka R, Bousbaine D, Li H, Patterson HC, Dougan SK, Maruyama T, Lodish HF, Ploegh HL. Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 28270614 DOI: 10.1073/Pnas.1701746114  0.354
2017 Van Elssen CH, Rashidian M, Vrbanac V, Wucherpfennig KW, El Habre Z, Sticht J, Freund C, Jacobsen J, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh H. Noninvasive imaging of human immune responses in a human xenograft model of graft-versus-host disease. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. PMID 28209904 DOI: 10.2967/Jnumed.116.186007  0.553
2017 Wu Q, Ploegh HL, Truttmann MC. Hepta-Mutant Staphylococcus aureus Sortase A (SrtA7m) as a Tool for in Vivo Protein Labeling in Caenorhabditis elegans. Acs Chemical Biology. PMID 28098972 DOI: 10.1021/Acschembio.6B00998  0.759
2017 Sanderson NS, Zimmermann M, Eilinger L, Gubser C, Schaeren-Wiemers N, Lindberg RL, Dougan SK, Ploegh HL, Kappos L, Derfuss T. Cocapture of cognate and bystander antigens can activate autoreactive B cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 28057865 DOI: 10.1073/Pnas.1614472114  0.366
2017 Rashidian M, Dougan M, Ingram J, Ploegh H. Abstract B18: Noninvasive imaging of antitumor immune responses Cancer Immunology Research. 5. DOI: 10.1158/2326-6074.Tumimm16-B18  0.321
2017 Tang C, Chang S, Paton A, Paton J, Gabrilovich D, Ploegh H, Valle JD, Hu CA. Abstract LB-336: Specific serine phosphorylation of IRE-1 controls enhanced splicing of XBP-1 and regulated IRE-1-dependent decay (RIDD) Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-336  0.319
2016 Bilate AM, Bousbaine D, Mesin L, Agudelo M, Leube J, Kratzert A, Dougan SK, Victora GD, Ploegh HL. Tissue-specific emergence of regulatory and intraepithelial T cells from a clonal T cell precursor. Science Immunology. 1: eaaf7471. PMID 28783695 DOI: 10.1126/Sciimmunol.Aaf7471  0.327
2016 Truttmann MC, Zheng X, Hanke L, Damon JR, Grootveld M, Krakowiak J, Pincus D, Ploegh HL. Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response. Proceedings of the National Academy of Sciences of the United States of America. PMID 28031489 DOI: 10.1073/Pnas.1619234114  0.747
2016 Swee LK, Tan ZW, Sanecka A, Yoshida N, Patel H, Grotenbreg G, Frickel EM, Ploegh HL. Peripheral self-reactivity regulates antigen-specific CD8 T-cell responses and cell division under physiological conditions. Open Biology. 6. PMID 27881740 DOI: 10.1098/Rsob.160293  0.346
2016 Duarte JN, Cragnolini JJ, Swee LK, Bilate AM, Bader J, Ingram JR, Rashidfarrokhi A, Fang T, Schiepers A, Hanke L, Ploegh HL. Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs. Journal of Immunology (Baltimore, Md. : 1950). PMID 27821668 DOI: 10.4049/Jimmunol.1600692  0.391
2016 Schmidt FI, Hanke L, Morin B, Brewer R, Brusic V, Whelan SP, Ploegh HL. Phenotypic lentivirus screens to identify functional single domain antibodies. Nature Microbiology. 1: 16080. PMID 27573105 DOI: 10.1038/Nmicrobiol.2016.80  0.328
2016 Hagiwara M, Ling J, Koenig PA, Ploegh HL. Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e. Molecular Cell. PMID 27570074 DOI: 10.1016/J.Molcel.2016.07.014  0.332
2016 von Rohrscheidt J, Petrozziello E, Nedjic J, Federle C, Krzyzak L, Ploegh HL, Ishido S, Steinkasserer A, Klein L. Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83. The Journal of Experimental Medicine. PMID 27503071 DOI: 10.1084/Jem.20160316  0.306
2016 Sanecka A, Yoshida N, Dougan SK, Jackson J, Shastri N, Ploegh H, Blanchard N, Frickel EM. Transnuclear CD8 T cells specific for the immunodominant epitope Gra6 lower acute phase Toxoplasma gondii burden. Immunology. PMID 27377596 DOI: 10.1111/Imm.12643  0.34
2016 Antos JM, Truttmann MC, Ploegh HL. Recent advances in sortase-catalyzed ligation methodology. Current Opinion in Structural Biology. 38: 111-118. PMID 27318815 DOI: 10.1016/J.Sbi.2016.05.021  0.714
2016 Dura B, Servos MM, Barry RM, Ploegh HL, Dougan SK, Voldman J. Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture. Proceedings of the National Academy of Sciences of the United States of America. PMID 27303033 DOI: 10.1073/Pnas.1515364113  0.317
2016 Truttmann MC, Cruz VE, Guo X, Engert C, Schwartz TU, Ploegh HL. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Plos Genetics. 12: e1006023. PMID 27138431 DOI: 10.1371/Journal.Pgen.1006023  0.739
2016 Schmidt FI, Lu A, Chen JW, Ruan J, Tang C, Wu H, Ploegh HL. A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. The Journal of Experimental Medicine. PMID 27069117 DOI: 10.1084/Jem.20151790  0.338
2016 Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Corrigendum: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nature Biotechnology. 34: 210. PMID 26849523 DOI: 10.1038/Nbt0216-210C  0.698
2016 Fang T, Duarte JN, Ling J, Li Z, Guzman JS, Ploegh HL. Structurally Defined αMHC-II Nanobody-Drug Conjugates: A Therapeutic and Imaging System for B-Cell Lymphoma. Angewandte Chemie (International Ed. in English). 55: 2416-20. PMID 26840214 DOI: 10.1002/Anie.201509432  0.316
2016 Jahan AS, Lestra M, Swee LK, Fan Y, Lamers MM, Tafesse FG, Theile CS, Spooner E, Bruzzone R, Ploegh HL, Sanyal S. Usp12 stabilizes the T-cell receptor complex at the cell surface during signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 26811477 DOI: 10.1073/Pnas.1521763113  0.379
2016 Elssen CV, Rashidian M, Vrbanac V, Freund C, Cragnolini J, Ingram J, Tager A, Ploegh H. Imaging Human Immune Cell Infiltration in a Xenograft Graft-Versus-Host Disease Model Blood. 128: 5720-5720. DOI: 10.1182/Blood.V128.22.5720.5720  0.352
2016 Rashidian M, Ploegh H. Abstract B080: Noninvasive imaging of antitumor responses as a possible predictive tool Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B080  0.326
2016 Dougan M, Ingram J, Blomberg O, Rashidian M, Keliher E, Weissleder R, Almo S, Ploegh H. Abstract B021: Single domain antibodies targeting CTLA-4 demonstrate a critical role for Fc in the antitumor response Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B021  0.314
2015 Rashidian M, Wang L, Eden JG, Jacobsen JT, Hossain I, Wang Q, Victora GD, Vasdev N, Ploegh H, Liang SH. Enzyme-Mediated Modification of Single-Domain Antibodies for Imaging Modalities with Different Characteristics. Angewandte Chemie (International Ed. in English). PMID 26630549 DOI: 10.1002/Anie.201507596  0.312
2015 Tafesse FG, Rashidfarrokhi A, Schmidt FI, Freinkman E, Dougan S, Dougan M, Esteban A, Maruyama T, Strijbis K, Ploegh HL. Disruption of Sphingolipid Biosynthesis Blocks Phagocytosis of Candida albicans. Plos Pathogens. 11: e1005188. PMID 26431038 DOI: 10.1371/Journal.Ppat.1005188  0.364
2015 Santone M, Aprea S, Wu TY, Cooke MP, Mbow ML, Valiante NM, Rush JS, Dougan S, Avalos A, Ploegh H, De Gregorio E, Buonsanti C, D'Oro U. A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells. Human Vaccines & Immunotherapeutics. 0. PMID 26024409 DOI: 10.1080/21645515.2015.1027467  0.363
2015 Rashidian M, Keliher EJ, Bilate AM, Duarte JN, Wojtkiewicz GR, Jacobsen JT, Cragnolini J, Swee LK, Victora GD, Weissleder R, Ploegh HL. Noninvasive imaging of immune responses. Proceedings of the National Academy of Sciences of the United States of America. 112: 6146-51. PMID 25902531 DOI: 10.1073/Pnas.1502609112  0.358
2015 Maruyama T, Dougan SK, Truttmann MC, Bilate AM, Ingram JR, Ploegh HL. Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nature Biotechnology. 33: 538-42. PMID 25798939 DOI: 10.1038/Nbt.3190  0.723
2015 Burg JS, Ingram JR, Venkatakrishnan AJ, Jude KM, Dukkipati A, Feinberg EN, Angelini A, Waghray D, Dror RO, Ploegh HL, Garcia KC. Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor. Science (New York, N.Y.). 347: 1113-7. PMID 25745166 DOI: 10.1126/Science.Aaa5026  0.305
2015 Truttmann MC, Wu Q, Stiegeler S, Duarte JN, Ingram J, Ploegh HL. HypE-specific nanobodies as tools to modulate HypE-mediated target AMPylation. The Journal of Biological Chemistry. 290: 9087-100. PMID 25678711 DOI: 10.1074/Jbc.M114.634287  0.752
2015 Dura B, Dougan SK, Barisa M, Hoehl MM, Lo CT, Ploegh HL, Voldman J. Profiling lymphocyte interactions at the single-cell level by microfluidic cell pairing. Nature Communications. 6: 5940. PMID 25585172 DOI: 10.1038/Ncomms6940  0.325
2015 Damon JR, Pincus D, Ploegh HL. tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae. Molecular Biology of the Cell. 26: 270-82. PMID 25392298 DOI: 10.1091/Mbc.E14-06-1145  0.303
2015 Swee LK, Lourido S, Bell GW, Ingram JR, Ploegh HL. One-step enzymatic modification of the cell surface redirects cellular cytotoxicity and parasite tropism. Acs Chemical Biology. 10: 460-5. PMID 25360987 DOI: 10.1021/Cb500462T  0.376
2015 Feng Y, Sokol ES, Vecchio CAD, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB. Abstract P2-07-01: EMT activates PERK-eIF2α signaling and sensitizes cells to perturbations in endoplasmic reticulum function Cancer Research. 75. DOI: 10.1158/1538-7445.Sabcs14-P2-07-01  0.334
2015 Dougan SK, Bilate A, Jaenisch R, Ploegh HL. Abstract B59: Transnuclear mice as models of the immune response to pancreatic cancer Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-B59  0.319
2014 Wuethrich I, Peeters JG, Blom AE, Theile CS, Li Z, Spooner E, Ploegh HL, Guimaraes CP. Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors. Plos One. 9: e109883. PMID 25275512 DOI: 10.1371/Journal.Pone.0109883  0.342
2014 Koenig PA, Ploegh HL. Protein quality control in the endoplasmic reticulum. F1000prime Reports. 6: 49. PMID 25184039 DOI: 10.12703/P6-49  0.327
2014 Tafesse FG, Guimaraes CP, Maruyama T, Carette JE, Lory S, Brummelkamp TR, Ploegh HL. GPR107, a G-protein-coupled receptor essential for intoxication by Pseudomonas aeruginosa exotoxin A, localizes to the Golgi and is cleaved by furin. The Journal of Biological Chemistry. 289: 24005-18. PMID 25031321 DOI: 10.1074/Jbc.M114.589275  0.332
2014 Shi J, Kundrat L, Pishesha N, Bilate A, Theile C, Maruyama T, Dougan SK, Ploegh HL, Lodish HF. Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes. Proceedings of the National Academy of Sciences of the United States of America. 111: 10131-6. PMID 24982154 DOI: 10.1073/Pnas.1409861111  0.337
2014 Strijbis K, Ploegh HL. Secretion of circular proteins using sortase. Methods in Molecular Biology (Clifton, N.J.). 1174: 73-83. PMID 24947375 DOI: 10.1007/978-1-4939-0944-5_5  0.337
2014 Avalos AM, Meyer-Wentrup F, Ploegh HL. B-cell receptor signaling in lymphoid malignancies and autoimmunity. Advances in Immunology. 123: 1-49. PMID 24840946 DOI: 10.1016/B978-0-12-800266-7.00004-2  0.322
2014 Lee CC, Freinkman E, Sabatini DM, Ploegh HL. The protein synthesis inhibitor blasticidin s enters mammalian cells via leucine-rich repeat-containing protein 8D. The Journal of Biological Chemistry. 289: 17124-31. PMID 24782309 DOI: 10.1074/Jbc.M114.571257  0.364
2014 Feng YX, Sokol ES, Del Vecchio CA, Sanduja S, Claessen JH, Proia TA, Jin DX, Reinhardt F, Ploegh HL, Wang Q, Gupta PB. Epithelial-to-mesenchymal transition activates PERK-eIF2α and sensitizes cells to endoplasmic reticulum stress. Cancer Discovery. 4: 702-15. PMID 24705811 DOI: 10.1158/2159-8290.Cd-13-0945  0.342
2014 Avalos AM, Ploegh HL. Early BCR Events and Antigen Capture, Processing, and Loading on MHC Class II on B Cells. Frontiers in Immunology. 5: 92. PMID 24653721 DOI: 10.3389/Fimmu.2014.00092  0.387
2014 Claessen JH, Sanyal S, Ploegh HL. The chaperone BAG6 captures dislocated glycoproteins in the cytosol. Plos One. 9: e90204. PMID 24594942 DOI: 10.1371/Journal.Pone.0090204  0.317
2014 Avalos AM, Bilate AM, Witte MD, Tai AK, He J, Frushicheva MP, Thill PD, Meyer-Wentrup F, Theile CS, Chakraborty AK, Zhuang X, Ploegh HL. Monovalent engagement of the BCR activates ovalbumin-specific transnuclear B cells. The Journal of Experimental Medicine. 211: 365-79. PMID 24493799 DOI: 10.1084/Jem.20131603  0.382
2014 Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, et al. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 506: 52-7. PMID 24476824 DOI: 10.1038/Nature12988  0.677
2013 Dougan SK, Ashour J, Karssemeijer RA, Popp MW, Avalos AM, Barisa M, Altenburg AF, Ingram JR, Cragnolini JJ, Guo C, Alt FW, Jaenisch R, Ploegh HL. Antigen-specific B-cell receptor sensitizes B cells to infection by influenza virus. Nature. 503: 406-9. PMID 24141948 DOI: 10.1038/Nature12637  0.301
2013 Witte MD, Theile CS, Wu T, Guimaraes CP, Blom AE, Ploegh HL. Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry. Nature Protocols. 8: 1808-19. PMID 23989675 DOI: 10.1038/Nprot.2013.103  0.319
2013 Theile CS, Witte MD, Blom AE, Kundrat L, Ploegh HL, Guimaraes CP. Site-specific N-terminal labeling of proteins using sortase-mediated reactions. Nature Protocols. 8: 1800-7. PMID 23989674 DOI: 10.1038/Nprot.2013.102  0.32
2013 Koenig PA, Spooner E, Kawamoto N, Strominger JL, Ploegh HL. Amino acid copolymers that alleviate experimental autoimmune encephalomyelitis in vivo interact with heparan sulfates and glycoprotein 96 in APCs. Journal of Immunology (Baltimore, Md. : 1950). 191: 208-16. PMID 23740953 DOI: 10.4049/Jimmunol.1300345  0.438
2013 Saha AK, Kappes F, Mundade A, Deutzmann A, Rosmarin DM, Legendre M, Chatain N, Al-Obaidi Z, Adams BS, Ploegh HL, Ferrando-May E, Mor-Vaknin N, Markovitz DM. Intercellular trafficking of the nuclear oncoprotein DEK. Proceedings of the National Academy of Sciences of the United States of America. 110: 6847-52. PMID 23569252 DOI: 10.1073/Pnas.1220751110  0.343
2013 Claessen JH, Witte MD, Yoder NC, Zhu AY, Spooner E, Ploegh HL. Catch-and-release probes applied to semi-intact cells reveal ubiquitin-specific protease expression in Chlamydia trachomatis infection. Chembiochem : a European Journal of Chemical Biology. 14: 343-52. PMID 23335262 DOI: 10.1002/Cbic.201200701  0.361
2013 Swee LK, Guimaraes CP, Sehrawat S, Spooner E, Barrasa MI, Ploegh HL. Sortase-mediated modification of αDEC205 affords optimization of antigen presentation and immunization against a set of viral epitopes. Proceedings of the National Academy of Sciences of the United States of America. 110: 1428-33. PMID 23297227 DOI: 10.1073/Pnas.1214994110  0.426
2013 Mukherjee S, Zhu J, Zikherman J, Parameswaran R, Kadlecek TA, Wang Q, Au-Yeung B, Ploegh H, Kuriyan J, Das J, Weiss A. Monovalent and multivalent ligation of the B cell receptor exhibit differential dependence upon Syk and Src family kinases Science Signaling. 6. PMID 23281368 DOI: 10.1126/Scisignal.2003220  0.305
2013 Sehrawat S, Koenig PA, Kirak O, Schlieker C, Fankhauser M, Ploegh HL. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood. 121: 1145-56. PMID 23243279 DOI: 10.1182/Blood-2012-08-447409  0.692
2013 Claessen JHL, Witte MD, Yoder NC, Zhu AY, Spooner E, Ploegh HL. Cover Picture: Catch-and-Release Probes Applied to Semi-Intact Cells Reveal Ubiquitin-Specific Protease Expression inChlamydia trachomatisInfection (ChemBioChem 3/2013) Chembiochem. 14: 269-269. DOI: 10.1002/Cbic.201390004  0.307
2012 Dougan SK, Ogata S, Hu CC, Grotenbreg GM, Guillen E, Jaenisch R, Ploegh HL. IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 13739-44. PMID 22869725 DOI: 10.1073/Pnas.1210273109  0.322
2012 Sehrawat S, Kirak O, Koenig PA, Isaacson MK, Marques S, Bozkurt G, Simas JP, Jaenisch R, Ploegh HL. CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection. Cell Reports. 1: 461-71. PMID 22832272 DOI: 10.1016/J.Celrep.2012.03.009  0.345
2012 Witte MD, Cragnolini JJ, Dougan SK, Yoder NC, Popp MW, Ploegh HL. Preparation of unnatural N-to-N and C-to-C protein fusions. Proceedings of the National Academy of Sciences of the United States of America. 109: 11993-8. PMID 22778432 DOI: 10.1073/Pnas.1205427109  0.304
2012 Hess GT, Cragnolini JJ, Popp MW, Allen MA, Dougan SK, Spooner E, Ploegh HL, Belcher AM, Guimaraes CP. M13 bacteriophage display framework that allows sortase-mediated modification of surface-accessible phage proteins. Bioconjugate Chemistry. 23: 1478-87. PMID 22759232 DOI: 10.1021/Bc300130Z  0.326
2012 Sanyal S, Claessen JH, Ploegh HL. A viral deubiquitylating enzyme restores dislocation of substrates from the endoplasmic reticulum (ER) in semi-intact cells. The Journal of Biological Chemistry. 287: 23594-603. PMID 22619172 DOI: 10.1074/Jbc.M112.365312  0.329
2012 Sinisi A, Popp MW, Antos JM, Pansegrau W, Savino S, Nissum M, Rappuoli R, Ploegh HL, Buti L. Development of an influenza virus protein array using Sortagging technology. Bioconjugate Chemistry. 23: 1119-26. PMID 22594688 DOI: 10.1021/Bc200577U  0.32
2012 van der Veen AG, Ploegh HL. Ubiquitin-like proteins. Annual Review of Biochemistry. 81: 323-57. PMID 22404627 DOI: 10.1146/Annurev-Biochem-093010-153308  0.324
2012 Strijbis K, Spooner E, Ploegh HL. Protein ligation in living cells using sortase. Traffic (Copenhagen, Denmark). 13: 780-9. PMID 22348280 DOI: 10.1111/J.1600-0854.2012.01345.X  0.362
2012 Olvera-Gomez I, Hamilton SE, Xiao Z, Guimaraes CP, Ploegh HL, Hogquist KA, Wang L, Jameson SC. Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination. Proceedings of the National Academy of Sciences of the United States of America. 109: 2072-7. PMID 22308317 DOI: 10.1073/Pnas.1105771109  0.332
2012 Lee CC, Avalos AM, Ploegh HL. Accessory molecules for Toll-like receptors and their function. Nature Reviews. Immunology. 12: 168-79. PMID 22301850 DOI: 10.1038/Nri3151  0.315
2012 Costantino CM, Spooner E, Ploegh HL, Hafler DA. Class II MHC self-antigen presentation in human B and T lymphocytes. Plos One. 7: e29805. PMID 22299025 DOI: 10.1371/Journal.Pone.0029805  0.4
2012 Claessen JH, Kundrat L, Ploegh HL. Protein quality control in the ER: balancing the ubiquitin checkbook. Trends in Cell Biology. 22: 22-32. PMID 22055166 DOI: 10.1016/J.Tcb.2011.09.010  0.319
2012 Dougan SK, Bilate A, Ploegh H. Abstract B75: Transnuclear mice from pancreatic tumor-infiltrating T cells. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-B75  0.319
2011 Claessen JH, Ploegh HL. BAT3 guides misfolded glycoproteins out of the endoplasmic reticulum. Plos One. 6: e28542. PMID 22174835 DOI: 10.1371/Journal.Pone.0028542  0.327
2011 Guimaraes CP, Carette JE, Varadarajan M, Antos J, Popp MW, Spooner E, Brummelkamp TR, Ploegh HL. Identification of host cell factors required for intoxication through use of modified cholera toxin. The Journal of Cell Biology. 195: 751-64. PMID 22123862 DOI: 10.1083/Jcb.201108103  0.384
2011 Smith MH, Ploegh HL, Weissman JS. Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science (New York, N.Y.). 334: 1086-90. PMID 22116878 DOI: 10.1126/Science.1209235  0.322
2011 Virreira Winter S, Niedelman W, Jensen KD, Rosowski EE, Julien L, Spooner E, Caradonna K, Burleigh BA, Saeij JP, Ploegh HL, Frickel EM. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. Plos One. 6: e24434. PMID 21931713 DOI: 10.1371/Journal.Pone.0024434  0.311
2011 Klemm EJ, Spooner E, Ploegh HL. Dual role of ancient ubiquitous protein 1 (AUP1) in lipid droplet accumulation and endoplasmic reticulum (ER) protein quality control. The Journal of Biological Chemistry. 286: 37602-14. PMID 21857022 DOI: 10.1074/Jbc.M111.284794  0.314
2011 Esteban A, Popp MW, Vyas VK, Strijbis K, Ploegh HL, Fink GR. Fungal recognition is mediated by the association of dectin-1 and galectin-3 in macrophages. Proceedings of the National Academy of Sciences of the United States of America. 108: 14270-5. PMID 21825168 DOI: 10.1073/Pnas.1111415108  0.313
2011 Buti L, Spooner E, Van der Veen AG, Rappuoli R, Covacci A, Ploegh HL. Helicobacter pylori cytotoxin-associated gene A (CagA) subverts the apoptosis-stimulating protein of p53 (ASPP2) tumor suppressor pathway of the host. Proceedings of the National Academy of Sciences of the United States of America. 108: 9238-43. PMID 21562218 DOI: 10.1073/Pnas.1106200108  0.323
2011 Bolscher JG, Oudhoff MJ, Nazmi K, Antos JM, Guimaraes CP, Spooner E, Haney EF, Garcia Vallejo JJ, Vogel HJ, van't Hof W, Ploegh HL, Veerman EC. Sortase A as a tool for high-yield histatin cyclization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 2650-8. PMID 21525488 DOI: 10.1096/Fj.11-182212  0.308
2011 Ernst R, Claessen JH, Mueller B, Sanyal S, Spooner E, van der Veen AG, Kirak O, Schlieker CD, Weihofen WA, Ploegh HL. Enzymatic blockade of the ubiquitin-proteasome pathway. Plos Biology. 8: e1000605. PMID 21468303 DOI: 10.1371/Journal.Pbio.1000605  0.678
2011 Popp MW, Dougan SK, Chuang TY, Spooner E, Ploegh HL. Sortase-catalyzed transformations that improve the properties of cytokines. Proceedings of the National Academy of Sciences of the United States of America. 108: 3169-74. PMID 21297034 DOI: 10.1073/Pnas.1016863108  0.347
2011 Daniel C, Ploegh H, von Boehmer H. Antigen-specific induction of regulatory T cells in vivo and in vitro. Methods in Molecular Biology (Clifton, N.J.). 707: 173-85. PMID 21287335 DOI: 10.1007/978-1-61737-979-6_11  0.377
2011 Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Molecular and Cellular Biology. 31: 1145-59. PMID 21220515 DOI: 10.1128/Mcb.00967-10  0.359
2011 Van der Veen AG, Schorpp K, Schlieker C, Buti L, Damon JR, Spooner E, Ploegh HL, Jentsch S. Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier. Proceedings of the National Academy of Sciences of the United States of America. 108: 1763-70. PMID 21209336 DOI: 10.1073/Pnas.1014402108  0.718
2010 Park B, Spooner E, Houser BL, Strominger JL, Ploegh HL. The HCMV membrane glycoprotein US10 selectively targets HLA-G for degradation. The Journal of Experimental Medicine. 207: 2033-41. PMID 20713594 DOI: 10.1084/Jem.20091793  0.794
2010 Hegde RS, Ploegh HL. Quality and quantity control at the endoplasmic reticulum. Current Opinion in Cell Biology. 22: 437-46. PMID 20570125 DOI: 10.1016/J.Ceb.2010.05.005  0.317
2010 Claessen JH, Mueller B, Spooner E, Pivorunas VL, Ploegh HL. The transmembrane segment of a tail-anchored protein determines its degradative fate through dislocation from the endoplasmic reticulum. The Journal of Biological Chemistry. 285: 20732-9. PMID 20435896 DOI: 10.1074/Jbc.M110.120766  0.333
2010 Greer PL, Hanayama R, Bloodgood BL, Mardinly AR, Lipton DM, Flavell SW, Kim TK, Griffith EC, Waldon Z, Maehr R, Ploegh HL, Chowdhury S, Worley PF, Steen J, Greenberg ME. The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc. Cell. 140: 704-16. PMID 20211139 DOI: 10.1016/J.Cell.2010.01.026  0.637
2010 Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. The Journal of Biological Chemistry. 285: 6857-66. PMID 20042598 DOI: 10.1074/Jbc.M109.072405  0.306
2010 Broxterman HJG, van der Marel GA, van Boom JH, Neefjes JJ, Ploegh HL. Synthesis of the antibiotic 1,5-dideoxy-1,5-imino-D-glucitol; concomitant formation of the D-mannitol analogue Recueil Des Travaux Chimiques Des Pays-Bas. 106: 571-576. DOI: 10.1002/recl.19871061105  0.367
2009 Ernst R, Mueller B, Ploegh HL, Schlieker C. The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Molecular Cell. 36: 28-38. PMID 19818707 DOI: 10.1016/J.Molcel.2009.09.016  0.687
2009 Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, Ploegh HL. Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. The Journal of Experimental Medicine. 206: 2429-40. PMID 19808260 DOI: 10.1084/Jem.20090782  0.368
2009 McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis. Journal of Immunology (Baltimore, Md. : 1950). 183: 3690-9. PMID 19710472 DOI: 10.4049/Jimmunol.0900953  0.389
2009 Gredmark-Russ S, Isaacson MK, Kattenhorn L, Cheung EJ, Watson N, Ploegh HL. A gammaherpesvirus ubiquitin-specific protease is involved in the establishment of murine gammaherpesvirus 68 infection. Journal of Virology. 83: 10644-52. PMID 19706716 DOI: 10.1128/Jvi.01017-09  0.321
2009 Antos JM, Chew GL, Guimaraes CP, Yoder NC, Grotenbreg GM, Popp MW, Ploegh HL. Site-specific N- and C-terminal labeling of a single polypeptide using sortases of different specificity. Journal of the American Chemical Society. 131: 10800-1. PMID 19610623 DOI: 10.1021/Ja902681K  0.56
2009 Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, et al. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. Journal of Immunology (Baltimore, Md. : 1950). 183: 1569-76. PMID 19587008 DOI: 10.4049/Jimmunol.0803899  0.304
2009 Costantino CM, Ploegh HL, Hafler DA. Cathepsin S regulates class II MHC processing in human CD4+ HLA-DR+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 945-52. PMID 19553543 DOI: 10.4049/Jimmunol.0900921  0.39
2009 Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. The Embo Journal. 28: 1624-36. PMID 19407814 DOI: 10.1038/Emboj.2009.117  0.532
2009 Popp MW, Antos JM, Ploegh HL. Site-specific protein labeling via sortase-mediated transpeptidation. Current Protocols in Protein Science / Editorial Board, John E. Coligan ... [Et Al.]. Unit 15.3. PMID 19365788 DOI: 10.1002/0471140864.Ps1503S56  0.381
2009 Antos JM, Popp MW, Ernst R, Chew GL, Spooner E, Ploegh HL. A straight path to circular proteins. The Journal of Biological Chemistry. 284: 16028-36. PMID 19359246 DOI: 10.1074/Jbc.M901752200  0.579
2009 Love KR, Pandya RK, Spooner E, Ploegh HL. Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery Acs Chemical Biology. 4: 275-287. PMID 19256548 DOI: 10.1021/Cb9000348  0.367
2009 Popp MW, Artavanis-Tsakonas K, Ploegh HL. Substrate filtering by the active site crossover loop in UCHL3 revealed by sortagging and gain-of-function mutations Journal of Biological Chemistry. 284: 3593-3602. PMID 19047059 DOI: 10.1074/Jbc.M807172200  0.305
2009 Costantino C, Ploegh H, Hafler D. S.132. Cathepsin S Regulates MHC Class II Processing in Human CD4+HLA-DR+T Cells Clinical Immunology. 131: S168. DOI: 10.1016/J.Clim.2009.03.498  0.344
2008 Schlieker CD, Van der Veen AG, Damon JR, Spooner E, Ploegh HL. A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proceedings of the National Academy of Sciences of the United States of America. 105: 18255-60. PMID 19017811 DOI: 10.1073/Pnas.0808756105  0.694
2008 Story CM, Papa E, Hu CC, Ronan JL, Herlihy K, Ploegh HL, Love JC. Profiling antibody responses by multiparametric analysis of primary B cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 17902-7. PMID 19004776 DOI: 10.1073/Pnas.0805470105  0.555
2008 Antos JM, Miller GM, Grotenbreg GM, Ploegh HL. Lipid modification of proteins through sortase-catalyzed transpeptidation. Journal of the American Chemical Society. 130: 16338-43. PMID 18989959 DOI: 10.1021/Ja806779E  0.336
2008 Gredmark-Russ S, Cheung EJ, Isaacson MK, Ploegh HL, Grotenbreg GM. The CD8 T-cell response against murine gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens. Journal of Virology. 82: 12205-12. PMID 18922872 DOI: 10.1128/Jvi.01463-08  0.369
2008 Frickel EM, Sahoo N, Hopp J, Gubbels MJ, Craver MP, Knoll LJ, Ploegh HL, Grotenbreg GM. Parasite stage-specific recognition of endogenous Toxoplasma gondii-derived CD8+ T cell epitopes. The Journal of Infectious Diseases. 198: 1625-33. PMID 18922097 DOI: 10.1086/593019  0.32
2008 Mueller B, Klemm EJ, Spooner E, Claessen JH, Ploegh HL. SEL1L nucleates a protein complex required for dislocation of misfolded glycoproteins Proceedings of the National Academy of Sciences of the United States of America. 105: 12325-12330. PMID 18711132 DOI: 10.1073/Pnas.0805371105  0.359
2008 Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Plough HL, Barrett TA, Weissleder R, Khazaie K. Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth. Plos One. 3: e2916. PMID 18698347 DOI: 10.1371/Journal.Pone.0002916  0.627
2008 Bradshaw EM, Kent SC, Tripuraneni V, Orban T, Ploegh HL, Hafler DA, Love JC. Concurrent detection of secreted products from human lymphocytes by microengraving: cytokines and antigen-reactive antibodies. Clinical Immunology (Orlando, Fla.). 129: 10-8. PMID 18675591 DOI: 10.1016/J.Clim.2008.06.009  0.58
2008 Vyas JM, Van Der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation Nature Reviews Immunology. 8: 607-618. PMID 18641646 DOI: 10.1038/Nri2368  0.362
2008 Costantino CM, Hang HC, Kent SC, Hafler DA, Ploegh HL. Lysosomal cysteine and aspartic proteases are heterogeneously expressed and act redundantly to initiate human invariant chain degradation. Journal of Immunology (Baltimore, Md. : 1950). 180: 2876-85. PMID 18292509 DOI: 10.4049/Jimmunol.180.5.2876  0.631
2008 Grotenbreg GM, Roan NR, Guillen E, Meijers R, Wang JH, Bell GW, Starnbach MN, Ploegh HL. Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proceedings of the National Academy of Sciences of the United States of America. 105: 3831-6. PMID 18245382 DOI: 10.1073/Pnas.0711504105  0.393
2008 Kario E, Tirosh B, Ploegh HL, Navon A. N-linked glycosylation does not impair proteasomal degradation but affects class I major histocompatibility complex presentation Journal of Biological Chemistry. 283: 244-254. PMID 17951257 DOI: 10.1074/Jbc.M706237200  0.377
2008 Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Ploegh HL, Barrett TA, Weissleder R, Khazaie K. Correction: Live Imaging of Cysteine-Cathepsin Activity Reveals Dynamics of Focal Inflammation, Angiogenesis, and Polyp Growth Plos One. 3. DOI: 10.1371/annotation/499b225f-e661-4124-aa2f-60bef89bd14a  0.599
2007 Jarosinski K, Kattenhorn L, Kaufer B, Ploegh H, Osterrieder N. A herpesvirus ubiquitin-specific protease is critical for efficient T cell lymphoma formation. Proceedings of the National Academy of Sciences of the United States of America. 104: 20025-30. PMID 18056809 DOI: 10.1073/Pnas.0706295104  0.359
2007 Ploegh HL. Bridging B cell and T cell recognition of antigen Journal of Immunology. 179: 7193. PMID 18025158 DOI: 10.4049/Jimmunol.179.11.7193  0.356
2007 Love KR, Catic A, Schlieker C, Ploegh HL. Mechanisms, biology and inhibitors of deubiquitinating enzymes. Nature Chemical Biology. 3: 697-705. PMID 17948018 DOI: 10.1038/Nchembio.2007.43  0.708
2007 Popp MW, Antos JM, Grotenbreg GM, Spooner E, Ploegh HL. Sortagging: a versatile method for protein labeling. Nature Chemical Biology. 3: 707-8. PMID 17891153 DOI: 10.1038/Nchembio.2007.31  0.356
2007 Ploegh HL. The peptide cargo of class I molecules: Not just passive passengers Journal of Immunology. 179: 4299-4300. PMID 17878322 DOI: 10.4049/Jimmunol.179.7.4299  0.337
2007 Derkow K, Loddenkemper C, Mintern J, Kruse N, Klugewitz K, Berg T, Wiedenmann B, Ploegh HL, Schott E. Differential priming of CD8 and CD4 T-cells in animal models of autoimmune hepatitis and cholangitis Hepatology. 46: 1155-1165. PMID 17657820 DOI: 10.1002/Hep.21796  0.301
2007 Catic A, Fiebiger E, Korbel GA, Blom D, Galardy PJ, Ploegh HL. Screen for ISG15-crossreactive deubiquitinases. Plos One. 2: e679. PMID 17653289 DOI: 10.1371/Journal.Pone.0000679  0.367
2007 Gredmark S, Schlieker C, Quesada V, Spooner E, Ploegh HL. A functional ubiquitin-specific protease embedded in the large tegument protein (ORF64) of murine gammaherpesvirus 68 is active during the course of infection. Journal of Virology. 81: 10300-9. PMID 17634221 DOI: 10.1128/Jvi.01149-07  0.712
2007 Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, Wucherpfennig KW. Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. The Journal of Biological Chemistry. 282: 21425-36. PMID 17525157 DOI: 10.1074/Jbc.M702844200  0.565
2007 Vyas JM, Kim YM, Artavanis-Tsakonas K, Love JC, Van der Veen AG, Ploegh HL. Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 7199-210. PMID 17513769 DOI: 10.4049/Jimmunol.178.11.7199  0.611
2007 Ryu KY, Maehr R, Gilchrist CA, Long MA, Bouley DM, Mueller B, Ploegh HL, Kopito RR. The mouse polyubiquitin gene UbC is essential for fetal liver development, cell-cycle progression and stress tolerance. The Embo Journal. 26: 2693-706. PMID 17491588 DOI: 10.1038/Sj.Emboj.7601722  0.657
2007 Grotenbreg G, Ploegh H. Chemical biology: dressed-up proteins. Nature. 446: 993-5. PMID 17460654 DOI: 10.1038/446993A  0.325
2007 Catic A, Misaghi S, Korbel GA, Ploegh HL. ElaD, a Deubiquitinating protease expressed by E. coli. Plos One. 2: e381. PMID 17440617 DOI: 10.1371/Journal.Pone.0000381  0.316
2007 Frickel EM, Quesada V, Muething L, Gubbels MJ, Spooner E, Ploegh H, Artavanis-Tsakonas K. Apicomplexan UCHL3 retains dual specificity for ubiquitin and Nedd8 throughout evolution. Cellular Microbiology. 9: 1601-10. PMID 17371404 DOI: 10.1111/J.1462-5822.2007.00896.X  0.37
2007 Gavanescu I, Kessler B, Ploegh H, Benoist C, Mathis D. Loss of Aire-dependent thymic expression of a peripheral tissue antigen renders it a target of autoimmunity. Proceedings of the National Academy of Sciences of the United States of America. 104: 4583-7. PMID 17360567 DOI: 10.1073/Pnas.0700259104  0.31
2007 Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Molecular Cell. 25: 677-87. PMID 17349955 DOI: 10.1016/J.Molcel.2007.01.033  0.689
2007 Hang HC, Geutjes EJ, Grotenbreg G, Pollington AM, Bijlmakers MJ, Ploegh HL. Chemical probes for the rapid detection of Fatty-acylated proteins in Mammalian cells. Journal of the American Chemical Society. 129: 2744-5. PMID 17305342 DOI: 10.1021/Ja0685001  0.608
2007 Kumazaki K, Tirosh B, Maehr R, Boes M, Honjo T, Ploegh HL. AID-/-μs-/- mice are agammaglobulinemic and fail to maintain B220-CD138+ plasma cells Journal of Immunology. 178: 2192-2203. PMID 17277124 DOI: 10.4049/Jimmunol.178.4.2192  0.676
2007 Costanti-England C, Hang H, Hafler D, Ploegh H. Haplotype-specific Use of Lysosomal Proteases Can Modulate the Class II MHC Peptide Repertoire but Does Not Impair Invariant Chain Degradation in Human Antigen Presenting Cells Clinical Immunology. 123: S53. DOI: 10.1016/J.Clim.2007.03.330  0.647
2006 Hang HC, Loureiro J, Spooner E, van der Velden AW, Kim YM, Pollington AM, Maehr R, Starnbach MN, Ploegh HL. Mechanism-based probe for the analysis of cathepsin cysteine proteases in living cells. Acs Chemical Biology. 1: 713-23. PMID 17184136 DOI: 10.1021/Cb600431A  0.761
2006 Loureiro J, Ploegh HL. Antigen Presentation and the Ubiquitin-Proteasome System in Host-Pathogen Interactions Advances in Immunology. 92: 225-305. PMID 17145306 DOI: 10.1016/S0065-2776(06)92006-9  0.381
2006 Mintern JD, Klemm EJ, Wagner M, Paquet ME, Napier MD, Kim YM, Koszinowski UH, Ploegh HL. Viral interference with B7-1 costimulation: a new role for murine cytomegalovirus fc receptor-1. Journal of Immunology (Baltimore, Md. : 1950). 177: 8422-31. PMID 17142739 DOI: 10.4049/Jimmunol.177.12.8422  0.337
2006 Artavanis-Tsakonas K, Love JC, Ploegh HL, Vyas JM. Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proceedings of the National Academy of Sciences of the United States of America. 103: 15945-50. PMID 17043215 DOI: 10.1073/Pnas.0607528103  0.583
2006 Mueller B, Lilley BN, Ploegh HL. SEL1L, the homologue of yeast Hrd3p, is involved in protein dislocation from the mammalian ER. The Journal of Cell Biology. 175: 261-70. PMID 17043138 DOI: 10.1083/Jcb.200605196  0.369
2006 Artavanis-Tsakonas K, Misaghi S, Comeaux CA, Catic A, Spooner E, Duraisingh MT, Ploegh HL. Identification by functional proteomics of a deubiquitinating/deNeddylating enzyme in Plasmodium falciparum Molecular Microbiology. 61: 1187-1195. PMID 16925553 DOI: 10.1111/J.1365-2958.2006.05307.X  0.332
2006 Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL. Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection. Journal of Virology. 80: 8739-44. PMID 16912321 DOI: 10.1128/Jvi.00791-06  0.32
2006 Patterson HCK, Kraus M, Kim YM, Ploegh H, Rajewsky K. The B Cell Receptor Promotes B Cell Activation and Proliferation through a Non-ITAM Tyrosine in the Igα Cytoplasmic Domain Immunity. 25: 55-65. PMID 16860757 DOI: 10.1016/J.Immuni.2006.04.014  0.344
2006 Shringarpure R, Catley L, Bhole D, Burger R, Podar K, Tai YT, Kessler B, Galardy P, Ploegh H, Tassone P, Hideshima T, Mitsiades C, Munshi NC, Chauhan D, Anderson KC. Gene expression analysis of B-lymphoma cells resistant and sensitive to bortezomib. British Journal of Haematology. 134: 145-56. PMID 16846475 DOI: 10.1111/J.1365-2141.2006.06132.X  0.305
2006 Koch KS, Son KH, Maehr R, Pellicciotta I, Ploegh HL, Zanetti M, Sell S, Leffert HL. Immune-privileged embryonic Swiss mouse STO and STO cell-derived progenitor cells: Major histocompatibility complex and cell differentiation antigen expression patterns resemble those of human embryonic stem cell lines Immunology. 119: 98-115. PMID 16836618 DOI: 10.1111/J.1365-2567.2006.02412.X  0.686
2006 Misaghi S, Balsara ZR, Catic A, Spooner E, Ploegh HL, Starnbach MN. Chlamydia trachomatis-derived deubiquitinating enzymes in mammalian cells during infection Molecular Microbiology. 61: 142-150. PMID 16824101 DOI: 10.1111/J.1365-2958.2006.05199.X  0.342
2006 Loureiro J, Lilley BN, Spooner E, Noriega V, Tortorella D, Ploegh HL. Signal peptide peptidase is required for dislocation from the endoplasmic reticulum. Nature. 441: 894-7. PMID 16738546 DOI: 10.1038/Nature04830  0.359
2006 Di Bacco A, Ouyang J, Lee HY, Catic A, Ploegh H, Gill G. The SUMO-specific protease SENP5 is required for cell division. Molecular and Cellular Biology. 26: 4489-98. PMID 16738315 DOI: 10.1128/Mcb.02301-05  0.359
2006 Wang J, Loveland AN, Kattenhorn LM, Ploegh HL, Gibson W. High-molecular-weight protein (pUL48) of human cytomegalovirus is a competent deubiquitinating protease: mutant viruses altered in its active-site cysteine or histidine are viable. Journal of Virology. 80: 6003-12. PMID 16731939 DOI: 10.1128/Jvi.00401-06  0.327
2006 Love JC, Ronan JL, Grotenbreg GM, van der Veen AG, Ploegh HL. A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nature Biotechnology. 24: 703-7. PMID 16699501 DOI: 10.1038/Nbt1210  0.565
2006 Huang TT, Nijman SM, Mirchandani KD, Galardy PJ, Cohn MA, Haas W, Gygi SP, Ploegh HL, Bernards R, D'Andrea AD. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nature Cell Biology. 8: 339-47. PMID 16531995 DOI: 10.1038/Ncb1378  0.318
2006 Kim YM, Pan JY, Korbel GA, Peperzak V, Boes M, Ploegh HL. Monovalent ligation of the B cell receptor induces receptor activation but fails to promote antigen presentation. Proceedings of the National Academy of Sciences of the United States of America. 103: 3327-32. PMID 16492756 DOI: 10.1073/Pnas.0511315103  0.388
2006 Nishibu A, Ward BR, Jester JV, Ploegh HL, Boes M, Takashima A. Behavioral responses of epidermal Langerhans cells in situ to local pathological stimuli Journal of Investigative Dermatology. 126: 787-796. PMID 16439974 DOI: 10.1038/Sj.Jid.5700107  0.308
2006 Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. Rapid turnover of unspliced Xbp-1 as a factor that modulates the unfolded protein response Journal of Biological Chemistry. 281: 5852-5860. PMID 16332684 DOI: 10.1074/Jbc.M509061200  0.327
2006 Galardy PJ, D’Andrea AD, Ploegh HL. The IL-2 Induced De-Ubiquitinating Enzyme, DUB-2, Is a Nuclear-Cytoplasmic Shuttle Which Requires Catalytic Activity for Nuclear Localization. Blood. 108: 868-868. DOI: 10.1182/Blood.V108.11.868.868  0.351
2006 Costantino C, Ploegh H, Baecher-Allan C, Hafler D. Sa.130. HLA-DR+ CD4+ T-Cells Have the Capacity to Present Endogenous Antigen Clinical Immunology. 119: S151. DOI: 10.1016/J.Clim.2006.04.362  0.334
2005 Ovaa H, Galardy PJ, Ploegh HL. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Synthesis of active site-directed probes Methods in Enzymology. 399: 468-478. PMID 16338376 DOI: 10.1016/S0076-6879(05)99032-0  0.364
2005 Galardy P, Ploegh HL, Ovaa H. Mechanism-based proteomics tools based on ubiquitin and ubiquitin-like proteins: Crystallography, activity profiling, and protease identification Methods in Enzymology. 399: 120-131. PMID 16338352 DOI: 10.1016/S0076-6879(05)99008-3  0.357
2005 Schlieker C, Korbel GA, Kattenhorn LM, Ploegh HL. A deubiquitinating activity is conserved in the large tegument protein of the herpesviridae. Journal of Virology. 79: 15582-5. PMID 16306630 DOI: 10.1128/Jvi.79.24.15582-15585.2005  0.691
2005 Lilley BN, Ploegh HL. Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane. Proceedings of the National Academy of Sciences of the United States of America. 102: 14296-301. PMID 16186509 DOI: 10.1073/Pnas.0505014102  0.337
2005 Catic A, Ploegh HL. Ubiquitin - Conserved protein or selfish gene? Trends in Biochemical Sciences. 30: 600-604. PMID 16185873 DOI: 10.1016/J.Tibs.2005.09.002  0.303
2005 Maehr R, Mintern JD, Herman AE, Lennon-Duménil AM, Mathis D, Benoist C, Ploegh HL. Cathepsin L is essential for onset of autoimmune diabetes in NOD mice. The Journal of Clinical Investigation. 115: 2934-43. PMID 16184198 DOI: 10.1172/Jci25485  0.647
2005 Lilley BN, Ploegh HL. Viral modulation of antigen presentation: manipulation of cellular targets in the ER and beyond. Immunological Reviews. 207: 126-44. PMID 16181332 DOI: 10.1111/J.0105-2896.2005.00318.X  0.384
2005 Altun M, Galardy PJ, Shringarpure R, Hideshima T, LeBlanc R, Anderson KC, Ploegh HL, Kessler BM. Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells Cancer Research. 65: 7896-7901. PMID 16140960 DOI: 10.1158/0008-5472.Can-05-0506  0.331
2005 Kattenhorn LM, Korbel GA, Kessler BM, Spooner E, Ploegh HL. A deubiquitinating enzyme encoded by HSV-1 belongs to a family of cysteine proteases that is conserved across the family Herpesviridae. Molecular Cell. 19: 547-57. PMID 16109378 DOI: 10.1016/J.Molcel.2005.07.003  0.361
2005 Tirosh B, Iwakoshi NN, Glimcher LH, Ploegh HL. XBP-1 specifically promotes IgM synthesis and secretion, but is dispensable for degradation of glycoproteins in primary B cells Journal of Experimental Medicine. 202: 505-516. PMID 16103408 DOI: 10.1084/Jem.20050575  0.377
2005 Boes M, van der Wel N, Peperzak V, Kim YM, Peters PJ, Ploegh H. In vivo control of endosomal architecture by class II-associated invariant chain and cathepsin S. European Journal of Immunology. 35: 2552-62. PMID 16094690 DOI: 10.1002/Eji.200526323  0.343
2005 Ploegh HL. A molecule's right to choose: How diabetogenic class II MHC products bind peptides Journal of Clinical Investigation. 115: 2077-2079. PMID 16075053 DOI: 10.1172/Jci26018  0.382
2005 Guerra L, Teter K, Lilley BN, Stenerlöw B, Holmes RK, Ploegh HL, Sandvig K, Thelestam M, Frisan T. Cellular internalization of cytolethal distending toxin: a new end to a known pathway. Cellular Microbiology. 7: 921-34. PMID 15953025 DOI: 10.1111/J.1462-5822.2005.00520.X  0.33
2005 Maehr R, Hang HC, Mintern JD, Kim YM, Cuvillier A, Nishimura M, Yamada K, Shirahama-Noda K, Hara-Nishimura I, Ploegh HL. Asparagine endopeptidase is not essential for class II MHC antigen presentation but is required for processing of cathepsin L in mice. Journal of Immunology (Baltimore, Md. : 1950). 174: 7066-74. PMID 15905550 DOI: 10.4049/Jimmunol.174.11.7066  0.769
2005 Ausubel LJ, O'Connor KC, Baecher-Allen C, Trollmo C, Kessler B, Hekking B, Merritt D, Meyer AL, Kwok B, Ploegh H, Huber BT, Hafler DA. Characterization of in vivo expanded OspA-specific human T-cell clones. Clinical Immunology (Orlando, Fla.). 115: 313-22. PMID 15893699 DOI: 10.1016/J.Clim.2005.02.015  0.38
2005 Berkers CR, Verdoes M, Lichtman E, Fiebiger E, Kessler BM, Anderson KC, Ploegh HL, Ovaa H, Galardy PJ. Activity probe for in vivo profiling of the specificity of proteasome inhibitor bortezomib Nature Methods. 2: 357-362. PMID 15846363 DOI: 10.1038/Nmeth759  0.331
2005 Tirosh B, Iwakoshi NN, Lilley BN, Lee AH, Glimcher LH, Ploegh HL. Human cytomegalovirus protein US11 provokes an unfolded protein response that may facilitate the degradation of class I major histocompatibility complex products. Journal of Virology. 79: 2768-79. PMID 15708995 DOI: 10.1128/Jvi.79.5.2768-2779.2005  0.368
2005 Borodovsky A, Ovaa H, Meester WJ, Venanzi ES, Bogyo MS, Hekking BG, Ploegh HL, Kessler BM, Overkleeft HS. Small-molecule inhibitors and probes for ubiquitin- and ubiquitin-like-specific proteases. Chembiochem : a European Journal of Chemical Biology. 6: 287-91. PMID 15651044 DOI: 10.1002/Cbic.200400236  0.644
2005 Fiebiger E, Tortorella D, Jouvin MH, Kinet JP, Ploegh HL. Cotranslational endoplasmic reticulum assembly of FcεRI controls the formation of functional IgE-binding receptors Journal of Experimental Medicine. 201: 267-277. PMID 15642744 DOI: 10.1084/Jem.20041384  0.331
2005 Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. The Journal of Biological Chemistry. 280: 1512-20. PMID 15531586 DOI: 10.1074/Jbc.M410770200  0.319
2005 Heemels MT, Ploegh H. Antigen presentation: untapped peptides. Current Biology : Cb. 3: 380-3. PMID 15335738 DOI: 10.1016/0960-9822(93)90208-6  0.375
2005 Ploegh H. Antigen presentation: immunologists co-opt cell biology. Trends in Cell Biology. 6: 255-6. PMID 15157450 DOI: 10.1016/0962-8924(96)20023-6  0.346
2004 Misaghi S, Pacold ME, Blom D, Ploegh HL, Korbel GA. Using a small molecule inhibitor of peptide: N-glycanase to probe its role in glycoprotein turnover. Chemistry & Biology. 11: 1677-87. PMID 15610852 DOI: 10.1016/J.Chembiol.2004.11.010  0.369
2004 Hang HC, Ploegh H. Catching proteases in action with microarrays. Chemistry & Biology. 11: 1328-30. PMID 15489158 DOI: 10.1016/J.Chembiol.2004.09.005  0.585
2004 Röhn TA, Boes M, Wolters D, Spindeldreher S, Müller B, Langen H, Ploegh H, Vogt AB, Kropshofer H. Upregulation of the CLIP self peptide on mature dendritic cells antagonizes T helper type 1 polarization. Nature Immunology. 5: 909-18. PMID 15322540 DOI: 10.1038/Ni1108  0.353
2004 Maehr R, Kraus M, Ploegh HL. Mice deficient in invariant-chain and MHC class II exhibit a normal mature B2 cell compartment. European Journal of Immunology. 34: 2230-6. PMID 15259020 DOI: 10.1002/Eji.200425246  0.689
2004 Boes M, Ploegh HL. Translating cell biology in vitro to immunity in vivo. Nature. 430: 264-71. PMID 15241425 DOI: 10.1038/Nature02762  0.34
2004 Lilley BN, Ploegh HL. A membrane protein required for dislocation of misfolded proteins from the ER. Nature. 429: 834-40. PMID 15215855 DOI: 10.1038/Nature02592  0.365
2004 Ploegh HL. Immunology. Nothing 'gainst time's scythe can make defense... Science (New York, N.Y.). 304: 1262-3. PMID 15166355 DOI: 10.1126/Science.1098965  0.312
2004 van Swieten PF, Maehr R, van den Nieuwendijk AM, Kessler BM, Reich M, Wong CS, Kalbacher H, Leeuwenburgh MA, Driessen C, van der Marel GA, Ploegh HL, Overkleeft HS. Development of an isotope-coded activity-based probe for the quantitative profiling of cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 14: 3131-4. PMID 15149659 DOI: 10.1016/J.Bmcl.2004.04.046  0.716
2004 Hemelaar J, Galardy PJ, Borodovsky A, Kessler BM, Ploegh HL, Ovaa H. Chemistry-based functional proteomics: mechanism-based activity-profiling tools for ubiquitin and ubiquitin-like specific proteases. Journal of Proteome Research. 3: 268-76. PMID 15113103 DOI: 10.1021/Pr0341080  0.321
2004 Schmidt-Supprian M, Tian J, Grant EP, Pasparakis M, Maehr R, Ovaa H, Ploegh HL, Coyle AJ, Rajewsky K. Differential dependence of CD4+CD25+ regulatory and natural killer-like T cells on signals leading to NF-κB activation Proceedings of the National Academy of Sciences of the United States of America. 101: 4566-4571. PMID 15070758 DOI: 10.1073/Pnas.0400885101  0.682
2004 Boes M, Cuvillier A, Ploegh H. Membrane specializations and endosome maturation in dendritic cells and B cells. Trends in Cell Biology. 14: 175-83. PMID 15066635 DOI: 10.1016/J.Tcb.2004.02.004  0.403
2004 Palliser D, Ploegh H, Boes M. Myeloid differentiation factor 88 is required for cross-priming in vivo. Journal of Immunology (Baltimore, Md. : 1950). 172: 3415-21. PMID 15004140 DOI: 10.4049/Jimmunol.172.6.3415  0.363
2004 Ovaa H, Kessler BM, Rolén U, Galardy PJ, Ploegh HL, Masucci MG. Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 2253-8. PMID 14982996 DOI: 10.1073/Pnas.0308411100  0.352
2004 Gil-Torregrosa BC, Lennon-Duménil AM, Kessler B, Guermonprez P, Ploegh HL, Fruci D, van Endert P, Amigorena S. Control of cross-presentation during dendritic cell maturation. European Journal of Immunology. 34: 398-407. PMID 14768044 DOI: 10.1002/Eji.200324508  0.361
2004 Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Molecular Biology of the Cell. 15: 1635-46. PMID 14767067 DOI: 10.1091/Mbc.E03-07-0506  0.397
2004 Blom D, Hirsch C, Stern P, Tortorella D, Ploegh HL. A glycosylated type I membrane protein becomes cytosolic when peptide: N-glycanase is compromised. The Embo Journal. 23: 650-8. PMID 14749736 DOI: 10.1038/Sj.Emboj.7600090  0.394
2004 Evans PC, Ovaa H, Hamon M, Kilshaw PJ, Hamm S, Bauer S, Ploegh HL, Smith TS. Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity. The Biochemical Journal. 378: 727-34. PMID 14748687 DOI: 10.1042/Bj20031377  0.358
2004 Bryant P, Ploegh H. Class II MHC peptide loading by the professionals. Current Opinion in Immunology. 16: 96-102. PMID 14734116 DOI: 10.1016/J.Coi.2003.11.011  0.383
2004 Hirsch C, Misaghi S, Blom D, Pacold ME, Ploegh HL. Yeast N-glycanase distinguishes between native and non-native glycoproteins Embo Reports. 5: 201-206. PMID 14726951 DOI: 10.1038/Sj.Embor.7400066  0.301
2004 Mintern JD, Maurice MM, Ploegh HL, Schott E. Thymic selection and peripheral activation of CD8 T cells by the same class I MHC/peptide complex. Journal of Immunology (Baltimore, Md. : 1950). 172: 699-708. PMID 14688383 DOI: 10.4049/Jimmunol.172.1.699  0.367
2004 Hemelaar J, Borodovsky A, Kessler BM, Reverter D, Cook J, Kolli N, Gan-Erdene T, Wilkinson KD, Gill G, Lima CD, Ploegh HL, Ovaa H. Specific and covalent targeting of conjugating and deconjugating enzymes of ubiquitin-like proteins. Molecular and Cellular Biology. 24: 84-95. PMID 14673145 DOI: 10.1128/Mcb.24.1.84-95.2004  0.383
2004 Misaghi S, Sun ZY, Stern P, Gaudet R, Wagner G, Ploegh H. Structural and functional analysis of human cytomegalovirus US3 protein. Journal of Virology. 78: 413-23. PMID 14671122 DOI: 10.1128/Jvi.78.1.413-423.2004  0.349
2003 Bertho N, Cerny J, Kim YM, Fiebiger E, Ploegh H, Boes M. Requirements for T cell-polarized tubulation of class II+ compartments in dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 5689-96. PMID 14634076 DOI: 10.4049/Jimmunol.171.11.5689  0.399
2003 Hudson AW, Blom D, Howley PM, Ploegh HL. The ER-lumenal domain of the HHV-7 immunoevasin U21 directs class I MHC molecules to lysosomes. Traffic (Copenhagen, Denmark). 4: 824-37. PMID 14617346 DOI: 10.1046/J.1398-9219.2003.0137.X  0.365
2003 Schott E, Bonasio R, Ploegh HL. Elimination in vivo of developing T cells by natural killer cells. The Journal of Experimental Medicine. 198: 1213-24. PMID 14568980 DOI: 10.1084/Jem.20030918  0.401
2003 Boes M, Bertho N, Cerny J, Op den Brouw M, Kirchhausen T, Ploegh H. T cells induce extended class II MHC compartments in dendritic cells in a Toll-like receptor-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 171: 4081-8. PMID 14530329 DOI: 10.4049/Jimmunol.171.8.4081  0.365
2003 Hemelaar J, Lelyveld VS, Kessler BM, Ploegh HL. A single protease, Apg4B, is specific for the autophagy-related ubiquitin-like proteins GATE-16, MAP1-LC3, GABARAP, and Apg8L. The Journal of Biological Chemistry. 278: 51841-50. PMID 14530254 DOI: 10.1074/Jbc.M308762200  0.335
2003 Kocks C, Maehr R, Overkleeft HS, Wang EW, Iyer LK, Lennon-Dumenil AM, Ploegh HL, Kessler BM. Functional proteomics of the active cysteine protease content in Drosophila S2 cells. Molecular & Cellular Proteomics : McP. 2: 1188-97. PMID 13130081 DOI: 10.1074/Mcp.M300067-Mcp200  0.735
2003 Lilley BN, Tortorella D, Ploegh HL. Dislocation of a type I membrane protein requires interactions between membrane-spanning segments within the lipid bilayer. Molecular Biology of the Cell. 14: 3690-8. PMID 12972557 DOI: 10.1091/Mbc.E03-03-0192  0.335
2003 Ovaa H, van Swieten PF, Kessler BM, Leeuwenburgh MA, Fiebiger E, van den Nieuwendijk AM, Galardy PJ, van der Marel GA, Ploegh HL, Overkleeft HS. Chemistry in living cells: detection of active proteasomes by a two-step labeling strategy. Angewandte Chemie (International Ed. in English). 42: 3626-9. PMID 12916032 DOI: 10.1002/Anie.200351314  0.496
2003 Furman MH, Loureiro J, Ploegh HL, Tortorella D. Ubiquitinylation of the cytosolic domain of a type I membrane protein is not required to initiate its dislocation from the endoplasmic reticulum. The Journal of Biological Chemistry. 278: 34804-11. PMID 12832421 DOI: 10.1074/Jbc.M300913200  0.371
2003 D'Orazio SEF, Halme DG, Ploegh HL, Starnbach MN. Class Ia MHC-deficient BALB/c mice generate CD8+ T cell-mediated protective immunity against listeria monocytogenes infection Journal of Immunology. 171: 291-298. PMID 12817010 DOI: 10.4049/Jimmunol.171.1.291  0.352
2003 Kisselev AF, Garcia-Calvo M, Overkleeft HS, Peterson E, Pennington MW, Ploegh HL, Thornberry NA, Goldberg AL. The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites. The Journal of Biological Chemistry. 278: 35869-77. PMID 12815064 DOI: 10.1074/Jbc.M303725200  0.487
2003 Hirsch C, Blom D, Ploegh HL. A role for N-glycanase in the cytosolic turnover of glycoproteins. The Embo Journal. 22: 1036-46. PMID 12606569 DOI: 10.1093/Emboj/Cdg107  0.347
2003 Kessler B, Hong X, Petrovic J, Borodovsky A, Dantuma NP, Bogyo M, Overkleeft HS, Ploegh H, Glas R. Pathways accessory to proteasomal proteolysis are less efficient in major histocompatibility complex class I antigen production. The Journal of Biological Chemistry. 278: 10013-21. PMID 12488316 DOI: 10.1074/Jbc.M211221200  0.538
2003 Tirosh B, Furman MH, Tortorella D, Ploegh HL. Protein unfolding is not a prerequisite for endoplasmic reticulum-to-cytosol dislocation. The Journal of Biological Chemistry. 278: 6664-72. PMID 12482753 DOI: 10.1074/Jbc.M210158200  0.341
2003 Schott E, Ploegh HL. Mouse MHC class I tetramers that are unable to bind to CD8 reveal the need for CD8 engagement in order to activate naive CD8 T cells. European Journal of Immunology. 32: 3425-34. PMID 12432573 DOI: 10.1002/1521-4141(200212)32:12<3425::Aid-Immu3425>3.0.Co;2-7  0.311
2003 Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM. Invariant chain controls the activity of extracellular cathepsin L. The Journal of Experimental Medicine. 196: 1263-9. PMID 12417635 DOI: 10.1084/jem.20020762  0.665
2002 Kalka-Moll WM, Tzianabos AO, Bryant PW, Niemeyer M, Ploegh HL, Kasper DL. Zwitterionic polysaccharides stimulate T cells by MHC class II-dependent interactions. Journal of Immunology (Baltimore, Md. : 1950). 169: 6149-53. PMID 12444118 DOI: 10.4049/Jimmunol.169.11.6149  0.399
2002 Vugmeyster Y, Borodovsky A, Maurice MM, Maehr R, Furman MH, Ploegh HL. The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP). Molecular Immunology. 39: 431-41. PMID 12413694 DOI: 10.1016/S0161-5890(02)00123-2  0.665
2002 Leggett DS, Hanna J, Borodovsky A, Crosas B, Schmidt M, Baker RT, Walz T, Ploegh H, Finley D. Multiple associated proteins regulate proteasome structure and function. Molecular Cell. 10: 495-507. PMID 12408819 DOI: 10.1016/S1097-2765(02)00638-X  0.322
2002 Borodovsky A, Ovaa H, Kolli N, Gan-Erdene T, Wilkinson KD, Ploegh HL, Kessler BM. Chemistry-based functional proteomics reveals novel members of the deubiquitinating enzyme family. Chemistry & Biology. 9: 1149-59. PMID 12401499 DOI: 10.1016/S1074-5521(02)00248-X  0.352
2002 Furman MH, Dey N, Tortorella D, Ploegh HL. The human cytomegalovirus US10 gene product delays trafficking of major histocompatibility complex class I molecules. Journal of Virology. 76: 11753-6. PMID 12388737 DOI: 10.1128/Jvi.76.22.11753-11756.2002  0.352
2002 Schott E, Bertho N, Ge Q, Maurice MM, Ploegh HL. Class I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules. Proceedings of the National Academy of Sciences of the United States of America. 99: 13735-40. PMID 12374858 DOI: 10.1073/Pnas.212515399  0.357
2002 Furman MH, Ploegh HL. Lessons from viral manipulation of protein disposal pathways. The Journal of Clinical Investigation. 110: 875-9. PMID 12370262 DOI: 10.1172/Jci16831  0.361
2002 Kessler BM, Glas R, Ploegh HL. MHC class I antigen processing regulated by cytosolic proteolysis-short cuts that alter peptide generation. Molecular Immunology. 39: 171-9. PMID 12200049 DOI: 10.1016/S0161-5890(02)00100-1  0.409
2002 Boes M, Cerny J, Massol R, Op den Brouw M, Kirchhausen T, Chen J, Ploegh HL. T-cell engagement of dendritic cells rapidly rearranges MHC class II transport. Nature. 418: 983-8. PMID 12198548 DOI: 10.1038/Nature01004  0.408
2002 Lennon-Duménil AM, Bakker AH, Maehr R, Fiebiger E, Overkleeft HS, Rosemblatt M, Ploegh HL, Lagaudrière-Gesbert C. Analysis of protease activity in live antigen-presenting cells shows regulation of the phagosomal proteolytic contents during dendritic cell activation. The Journal of Experimental Medicine. 196: 529-40. PMID 12186844 DOI: 10.1084/jem.20020327  0.719
2002 Bryant PW, Lennon-Duménil AM, Fiebiger E, Lagaudrière-Gesbert C, Ploegh HL. Proteolysis and antigen presentation by MHC class II molecules. Advances in Immunology. 80: 71-114. PMID 12078484 DOI: 10.1016/S0065-2776(02)80013-X  0.468
2002 Tirabassi RS, Ploegh HL. The human cytomegalovirus US8 glycoprotein binds to major histocompatibility complex class I products. Journal of Virology. 76: 6832-5. PMID 12050396 DOI: 10.1128/Jvi.76.13.6832-6835.2002  0.374
2002 Lorenzo ME, Jung JU, Ploegh HL. Kaposi's sarcoma-associated herpesvirus K3 utilizes the ubiquitin-proteasome system in routing class I major histocompatibility complexes to late endocytic compartments Journal of Virology. 76: 5522-5531. PMID 11991980 DOI: 10.1128/Jvi.76.11.5522-5531.2002  0.343
2002 Rehm A, Engelsberg A, Tortorella D, Körner IJ, Lehmann I, Ploegh HL, Höpken UE. Human cytomegalovirus gene products US2 and US11 differ in their ability to attack major histocompatibility class I heavy chains in dendritic cells. Journal of Virology. 76: 5043-50. PMID 11967320 DOI: 10.1128/Jvi.76.10.5043-5050.2002  0.383
2002 Fiebiger E, Story C, Ploegh HL, Tortorella D. Visualization of the ER-to-cytosol dislocation reaction of a type I membrane protein. The Embo Journal. 21: 1041-53. PMID 11867532 DOI: 10.1093/Emboj/21.5.1041  0.377
2002 Lagaudrière-Gesbert C, Newmyer SL, Gregers TF, Bakke O, Ploegh HL. Uncoating ATPase Hsc70 is recruited by invariant chain and controls the size of endocytic compartments. Proceedings of the National Academy of Sciences of the United States of America. 99: 1515-20. PMID 11818572 DOI: 10.1073/Pnas.042688099  0.365
2002 Plüger EB, Boes M, Alfonso C, Schröter CJ, Kalbacher H, Ploegh HL, Driessen C. Specific role for cathepsin S in the generation of antigenic peptides in vivo. European Journal of Immunology. 32: 467-76. PMID 11813165 DOI: 10.1002/1521-4141(200202)32:2<467::Aid-Immu467>3.0.Co;2-Y  0.419
2002 Gewurz BE, Ploegh HL, Tortorella D. US2, a human cytomegalovirus-encoded type I membrane protein, contains a non-cleavable amino-terminal signal peptide. The Journal of Biological Chemistry. 277: 11306-13. PMID 11790769 DOI: 10.1074/Jbc.M107904200  0.349
2002 Lennon-Duménil AM, Bakker AH, Wolf-Bryant P, Ploegh HL, Lagaudrière-Gesbert C. A closer look at proteolysis and MHC-class-II-restricted antigen presentation. Current Opinion in Immunology. 14: 15-21. PMID 11790528 DOI: 10.1016/S0952-7915(01)00293-X  0.393
2002 Hudson AW, Ploegh HL. The cell biology of antigen presentation. Experimental Cell Research. 272: 1-7. PMID 11740859 DOI: 10.1006/Excr.2001.5402  0.345
2002 Furman MH, Ploegh HL, Tortorella D. Membrane-specific, host-derived factors are required for US2- and US11-mediated degradation of major histocompatibility complex class I molecules. The Journal of Biological Chemistry. 277: 3258-67. PMID 11717308 DOI: 10.1074/Jbc.M109765200  0.356
2002 Gould DS, Ploegh HL, Schust DJ. Murine female reproductive tract intraepithelial lymphocytes display selection characteristics distinct from both peripheral and other mucosal T cells. Journal of Reproductive Immunology. 52: 85-99. PMID 11600180 DOI: 10.1016/S0165-0378(01)00110-3  0.336
2001 Hudson AW, Howley PM, Ploegh HL. A human herpesvirus 7 glycoprotein, U21, diverts major histocompatibility complex class I molecules to lysosomes. Journal of Virology. 75: 12347-58. PMID 11711625 DOI: 10.1128/Jvi.75.24.12347-12358.2001  0.362
2001 Lilley BN, Ploegh HL, Tirabassi RS. Human cytomegalovirus open reading frame TRL11/IRL11 encodes an immunoglobulin G Fc-binding protein. Journal of Virology. 75: 11218-21. PMID 11602761 DOI: 10.1128/Jvi.75.22.11218-11221.2001  0.317
2001 Borodovsky A, Kessler BM, Casagrande R, Overkleeft HS, Wilkinson KD, Ploegh HL. A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14. The Embo Journal. 20: 5187-96. PMID 11566882 DOI: 10.1093/Emboj/20.18.5187  0.524
2001 Kessler BM, Tortorella D, Altun M, Kisselev AF, Fiebiger E, Hekking BG, Ploegh HL, Overkleeft HS. Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits. Chemistry & Biology. 8: 913-29. PMID 11564559 DOI: 10.1016/S1074-5521(01)00069-2  0.538
2001 Shamu CE, Flierman D, Ploegh HL, Rapoport TA, Chau V. Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Molecular Biology of the Cell. 12: 2546-55. PMID 11514634 DOI: 10.1091/Mbc.12.8.2546  0.369
2001 Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL. Virus subversion of immunity: a structural perspective. Current Opinion in Immunology. 13: 442-50. PMID 11498300 DOI: 10.1016/S0952-7915(00)00239-9  0.302
2001 Lennon-Duménil AM, Roberts RA, Valentijn K, Driessen C, Overkleeft HS, Erickson A, Peters PJ, Bikoff E, Ploegh HL, Wolf Bryant P. The p41 isoform of invariant chain is a chaperone for cathepsin L. The Embo Journal. 20: 4055-64. PMID 11483509 DOI: 10.1093/Emboj/20.15.4055  0.535
2001 Driessen C, Lennon-Duménil AM, Ploegh HL. Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors. European Journal of Immunology. 31: 1592-601. PMID 11465117 DOI: 10.1002/1521-4141(200105)31:5<1592::Aid-Immu1592>3.0.Co;2-K  0.345
2001 Maurice MM, Gould DS, Carroll J, Vugmeyster Y, Ploegh HL. Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proceedings of the National Academy of Sciences of the United States of America. 98: 7437-42. PMID 11404484 DOI: 10.1073/Pnas.141143298  0.333
2001 Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, Wiley DC. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proceedings of the National Academy of Sciences of the United States of America. 98: 6794-9. PMID 11391001 DOI: 10.1073/Pnas.121172898  0.397
2001 Gewurz BE, Wang EW, Tortorella D, Schust DJ, Ploegh HL. Human cytomegalovirus US2 endoplasmic reticulum-lumenal domain dictates association with major histocompatibility complex class I in a locus-specific manner. Journal of Virology. 75: 5197-204. PMID 11333901 DOI: 10.1128/Jvi.75.11.5197-5204.2001  0.39
2001 Abendroth A, Lin I, Slobedman B, Ploegh H, Arvin AM. Varicella-zoster virus retains major histocompatibility complex class I proteins in the golgi compartment of infected cells Journal of Virology. 75: 4878-4888. PMID 11312359 DOI: 10.1128/Jvi.75.10.4878-4888.2001  0.388
2001 Fiebiger E, Meraner P, Weber E, Fang IF, Stingl G, Ploegh H, Maurer D. Cytokines regulate proteolysis in major histocompatibility complex class II-dependent antigen presentation by dendritic cells. The Journal of Experimental Medicine. 193: 881-92. PMID 11304549 DOI: 10.1084/Jem.193.8.881  0.39
2001 Rehm A, Stern P, Ploegh HL, Tortorella D. Signal peptide cleavage of a type I membrane protein, HCMV US11, is dependent on its membrane anchor. The Embo Journal. 20: 1573-82. PMID 11285222 DOI: 10.1093/Emboj/20.7.1573  0.321
2001 Hsu PN, Wolf Bryant P, Sutkowski N, McLellan B, Ploegh HL, Huber BT. Association of mouse mammary tumor virus superantigen with MHC class II during biosynthesis. Journal of Immunology (Baltimore, Md. : 1950). 166: 3309-14. PMID 11207286 DOI: 10.4049/Jimmunol.166.5.3309  0.362
2001 Furman MH, Ploegh HL, Schust DJ. Can viruses help us to understand and classify the MHC class I molecules at the maternal-fetal interface? Human Immunology. 61: 1169-76. PMID 11137223 DOI: 10.1016/S0198-8859(00)00203-2  0.32
2000 Das G, Gould DS, Augustine MM, Fragoso G, Sciutto E, Stroynowski I, Van Kaer L, Schust DJ, Ploegh H, Janeway CA. Qa-2-dependent selection of CD8α/α T cell receptor α/β+ cells in murine intestinal intraepithelial lymphocytes Journal of Experimental Medicine. 192: 1521-1527. PMID 11085754 DOI: 10.1084/Jem.193.3.413  0.325
2000 Wang EW, Kessler BM, Borodovsky A, Cravatt BF, Bogyo M, Ploegh HL, Glas R. Integration of the ubiquitin-proteasome pathway with a cytosolic oligopeptidase activity. Proceedings of the National Academy of Sciences of the United States of America. 97: 9990-5. PMID 10954757 DOI: 10.1073/Pnas.180328897  0.548
2000 Weihofen A, Lemberg MK, Ploegh HL, Bogyo M, Martoglio B. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor. The Journal of Biological Chemistry. 275: 30951-6. PMID 10921927 DOI: 10.1074/Jbc.M005980200  0.55
2000 Casagrande R, Stern P, Diehn M, Shamu C, Osario M, Zúñiga M, Brown PO, Ploegh H. Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway. Molecular Cell. 5: 729-35. PMID 10882108 DOI: 10.1016/S1097-2765(00)80251-8  0.335
2000 Hirsch C, Ploegh HL. Intracellular targeting of the proteasome. Trends in Cell Biology. 10: 268-72. PMID 10856929 DOI: 10.1016/S0962-8924(00)01768-2  0.321
2000 Tortorella D, Gewurz B, Schust D, Furman M, Ploegh H. Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. Immunological Investigations. 29: 97-100. PMID 10854174 DOI: 10.3109/08820130009062289  0.438
2000 Villadangos JA, Ploegh HL. Proteolysis in MHC class II antigen presentation: who's in charge? Immunity. 12: 233-9. PMID 10755610 DOI: 10.1016/S1074-7613(00)80176-4  0.416
2000 Shi GP, Bryant RA, Riese R, Verhelst S, Driessen C, Li Z, Bromme D, Ploegh HL, Chapman HA. Role for cathepsin F in invariant chain processing and major histocompatibility complex class II peptide loading by macrophages. The Journal of Experimental Medicine. 191: 1177-86. PMID 10748235 DOI: 10.1084/Jem.191.7.1177  0.365
2000 Villadangos JA, Driessen C, Shi GP, Chapman HA, Ploegh HL. Early endosomal maturation of MHC class II molecules independently of cysteine proteases and H-2DM. The Embo Journal. 19: 882-91. PMID 10698930 DOI: 10.1093/Emboj/19.5.882  0.358
1999 Villadangos JA, Bryant RA, Deussing J, Driessen C, Lennon-Duménil AM, Riese RJ, Roth W, Saftig P, Shi GP, Chapman HA, Peters C, Ploegh HL. Proteases involved in MHC class II antigen presentation. Immunological Reviews. 172: 109-20. PMID 10631941 DOI: 10.1111/J.1600-065X.1999.Tb01360.X  0.419
1999 Driessen C, Bryant RA, Lennon-Duménil AM, Villadangos JA, Bryant PW, Shi GP, Chapman HA, Ploegh HL. Cathepsin S controls the trafficking and maturation of MHC class II molecules in dendritic cells. The Journal of Cell Biology. 147: 775-90. PMID 10562280 DOI: 10.1083/Jcb.147.4.775  0.369
1999 Shamu CE, Story CM, Rapoport TA, Ploegh HL. The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. The Journal of Cell Biology. 147: 45-58. PMID 10508854 DOI: 10.1083/Jcb.147.1.45  0.341
1999 Bryant PW, Roos P, Ploegh HL, Sant AJ. Deviant trafficking of I-A(d) mutant molecules is reflected in their peptide binding properties European Journal of Immunology. 29: 2729-2739. PMID 10508247 DOI: 10.1002/(Sici)1521-4141(199909)29:09<2729::Aid-Immu2729>3.0.Co;2-A  0.344
1999 Schust DJ, Tortorella D, Ploegh HL. Viral immunoevasive strategies and trophoblast class I major histocompatibility complex antigens. Journal of Reproductive Immunology. 43: 243-51. PMID 10479060 DOI: 10.1016/S0165-0378(99)00024-8  0.337
1999 Story CM, Furman MH, Ploegh HL. The cytosolic tail of class I MHC heavy chain is required for its dislocation by the human cytomegalovirus US2 and US11 gene products. Proceedings of the National Academy of Sciences of the United States of America. 96: 8516-21. PMID 10411907 DOI: 10.1073/Pnas.96.15.8516  0.322
1999 Schust DJ, Tortorella D, Ploegh HL. HLA-G and HLA-C at the feto-maternal interface: lessons learned from pathogenic viruses. Seminars in Cancer Biology. 9: 37-46. PMID 10092549 DOI: 10.1006/Scbi.1998.0106  0.326
1999 Shi GP, Villadangos JA, Dranoff G, Small C, Gu L, Haley KJ, Riese R, Ploegh HL, Chapman HA. Cathepsin S required for normal MHC class II peptide loading and germinal center development. Immunity. 10: 197-206. PMID 10072072 DOI: 10.1016/S1074-7613(00)80020-5  0.405
1999 Bogyo M, Ploegh HL. Antigen presentation. A protease draws first blood. Nature. 396: 625, 627. PMID 9872306 DOI: 10.1038/25238  0.566
1998 Sykulev Y, Vugmeyster Y, Brunmark A, Ploegh HL, Eisen HN. Peptide antagonism and T cell receptor interactions with peptide-MHC complexes. Immunity. 9: 475-83. PMID 9806634 DOI: 10.1016/S1074-7613(00)80631-7  0.362
1998 Vugmeyster Y, Glas R, Pérarnau B, Lemonnier FA, Eisen H, Ploegh H. Major histocompatibility complex (MHC) class I KbDb -/- deficient mice possess functional CD8+ T cells and natural killer cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 12492-7. PMID 9770513 DOI: 10.1073/Pnas.95.21.12492  0.381
1998 Wolf PR, Tourne S, Miyazaki T, Benoist C, Mathis D, Ploegh HL. The phenotype of H-2M-deficient mice is dependent on the MHC class II molecules expressed. European Journal of Immunology. 28: 2605-18. PMID 9754549 DOI: 10.1002/(Sici)1521-4141(199809)28:09<2605::Aid-Immu2605>3.0.Co;2-B  0.394
1998 Sernee MF, Ploegh HL, Schust DJ. Why certain antibodies cross-react with HLA-A and HLA-G: epitope mapping of two common MHC class I reagents. Molecular Immunology. 35: 177-88. PMID 9694518 DOI: 10.1016/S0161-5890(98)00026-1  0.366
1998 Schust DJ, Tortorella D, Seebach J, Phan C, Ploegh HL. Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. The Journal of Experimental Medicine. 188: 497-503. PMID 9687527 DOI: 10.1084/Jem.188.3.497  0.383
1998 Tortorella D, Story CM, Huppa JB, Wiertz EJ, Jones TR, Bacik I, Bennink JR, Yewdell JW, Ploegh HL. Dislocation of type I membrane proteins from the ER to the cytosol is sensitive to changes in redox potential. The Journal of Cell Biology. 142: 365-76. PMID 9679137 DOI: 10.1083/Jcb.142.2.365  0.319
1998 Bogyo M, Shin S, McMaster JS, Ploegh HL. Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes Chemistry and Biology. 5: 307-320. PMID 9653549 DOI: 10.1016/S1074-5521(98)90169-7  0.539
1998 Riese RJ, Mitchell RN, Villadangos JA, Shi GP, Palmer JT, Karp ER, De Sanctis GT, Ploegh HL, Chapman HA. Cathepsin S activity regulates antigen presentation and immunity. The Journal of Clinical Investigation. 101: 2351-63. PMID 9616206 DOI: 10.1172/Jci1158  0.408
1998 Jugovic P, Hill AM, Tomazin R, Ploegh H, Johnson DC. Inhibition of major histocompatibility complex class I antigen presentation in pig and primate cells by herpes simplex virus type 1 and 2 ICP47. Journal of Virology. 72: 5076-84. PMID 9573278 DOI: 10.1128/Jvi.72.6.5076-5084.1998  0.39
1998 Glas R, Bogyo M, McMaster JS, Gaczynska M, Ploegh HL. A proteolytic system that compensates for loss of proteasome function Nature. 392: 618-622. PMID 9560160 DOI: 10.1038/33443  0.592
1998 Nakagawa T, Roth W, Wong P, Nelson A, Farr A, Deussing J, Villadangos JA, Ploegh H, Peters C, Rudensky AY. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science (New York, N.Y.). 280: 450-3. PMID 9545226 DOI: 10.1126/Science.280.5362.450  0.377
1998 Deussing J, Roth W, Saftig P, Peters C, Ploegh HL, Villadangos JA. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation. Proceedings of the National Academy of Sciences of the United States of America. 95: 4516-21. PMID 9539769 DOI: 10.1073/Pnas.95.8.4516  0.374
1997 Simmons WA, Roopenian DC, Summerfield SG, Jones RC, Galocha B, Christianson GJ, Maika SD, Zhou M, Gaskell SJ, Bordoli RS, Ploegh HL, Slaughter CA, Lindahl KF, Hammer RE, Taurog JD. A new MHC locus that influences class I peptide presentation. Immunity. 7: 641-51. PMID 9390688 DOI: 10.1016/S1074-7613(00)80385-4  0.351
1997 Bogyo M, Gaczynska M, Ploegh HL. Proteasome inhibitors and antigen presentation. Biopolymers. 43: 269-80. PMID 9316392 DOI: 10.1002/(Sici)1097-0282(1997)43:4<269::Aid-Bip2>3.0.Co;2-T  0.593
1997 Tourne S, Miyazaki T, Wolf P, Ploegh H, Benoist C, Mathis D. Functionality of major histocompatibility complex class II molecules in mice doubly deficient for invariant chain and H-2M complexes. Proceedings of the National Academy of Sciences of the United States of America. 94: 9255-60. PMID 9256469 DOI: 10.1073/Pnas.94.17.9255  0.362
1997 Villadangos JA, Riese RJ, Peters C, Chapman HA, Ploegh HL. Degradation of mouse invariant chain: Roles of cathepsins S and D and the influence of major histocompatibility complex polymorphism Journal of Experimental Medicine. 186: 549-560. PMID 9254653 DOI: 10.1084/Jem.186.4.549  0.38
1997 Huppa JB, Ploegh HL. The alpha chain of the T cell antigen receptor is degraded in the cytosol. Immunity. 7: 113-22. PMID 9252124 DOI: 10.1016/S1074-7613(00)80514-2  0.34
1997 Wiertz E, Hill A, Tortorella D, Ploegh H. Cytomegaloviruses use multiple mechanisms to elude the host immune response. Immunology Letters. 57: 213-6. PMID 9232454 DOI: 10.1016/S0165-2478(97)00073-4  0.325
1997 Bogyo M, McMaster JS, Gaczynska M, Tortorella D, Goldberg AL, Ploegh H. Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HsIV by a new class of inhibitors Proceedings of the National Academy of Sciences of the United States of America. 94: 6629-6634. PMID 9192616 DOI: 10.1073/Pnas.94.13.6629  0.561
1997 Ahn K, Gruhler A, Galocha B, Jones TR, Wiertz EJHJ, Ploegh HL, Peterson PA, Yang Y, Früh K. The ER-luminal domain of the HCMV glypcoprotein US6 inhibits peptide translocation by TAP Immunity. 6: 613-621. PMID 9175839 DOI: 10.1016/S1074-7613(00)80349-0  0.389
1997 Galocha B, Hill A, Barnett BC, Dolan A, Raimondi A, Cook RF, Brunner J, McGeoch DJ, Ploegh HL. The active site of ICP47, a herpes simplex virus-encoded inhibitor of the major histocompatibility complex (MHC)-encoded peptide transporter associated with antigen processing (TAP), maps to the NH2-terminal 35 residues. The Journal of Experimental Medicine. 185: 1565-72. PMID 9151894 DOI: 10.1084/Jem.185.9.1565  0.392
1997 Kleijnen MF, Huppa JB, Lucin P, Mukherjee S, Farrell H, Campbell AE, Koszinowski UH, Hill AB, Ploegh HL. A mouse cytomegalovirus glycoprotein, gp34, forms a complex with folded class I MHC molecules in the ER which is not retained but is transported to the cell surface. The Embo Journal. 16: 685-94. PMID 9049298 DOI: 10.1093/Emboj/16.4.685  0.353
1997 Rehm A, Ploegh HL. Monoclonal antibodies that distinguish between free and complexed heterotrimeric G protein beta subunits. Febs Letters. 402: 277-85. PMID 9037210 DOI: 10.1016/S0014-5793(96)01457-3  0.302
1997 Machold RP, Wiertz EJHJ, Jones TR, Ploegh HL. The HCMV Gene Products US11 and US2 Differ in Their Ability to Attack Allelic Forms of Murine Major Histocompatibility Complex (MHC) Class I Heavy Chains Journal of Experimental Medicine. 185: 363-366. PMID 9016885 DOI: 10.1084/Jem.185.2.363  0.365
1997 Machold RP, Ploegh HL. Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies. The Journal of Experimental Medicine. 184: 2251-9. PMID 8976180 DOI: 10.1084/Jem.184.6.2251  0.35
1997 Wiertz EJ, Tortorella D, Bogyo M, Yu J, Galocha B, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Cytomegalovirus uses multiple strategies to interfere with MHC class I-restricted antigen presentation Immunology Letters. 56: 189. DOI: 10.1016/S0165-2478(97)85759-8  0.343
1996 Wiertz EJ, Tortorella D, Bogyo M, Yu J, Mothes W, Jones TR, Rapoport TA, Ploegh HL. Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction. Nature. 384: 432-8. PMID 8945469 DOI: 10.1038/384432A0  0.573
1996 Mazzaccaro RJ, Gedde M, Jensen ER, van Santen HM, Ploegh HL, Rock KL, Bloom BR. Major histocompatibility class I presentation of soluble antigen facilitated by Mycobacterium tuberculosis infection. Proceedings of the National Academy of Sciences of the United States of America. 93: 11786-91. PMID 8876215 DOI: 10.1073/Pnas.93.21.11786  0.412
1996 Jones TR, Wiertz EJHJ, Sun L, Fish KN, Nelson JA, Ploegh HL. Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains Proceedings of the National Academy of Sciences of the United States of America. 93: 11327-11333. PMID 8876135 DOI: 10.1073/Pnas.93.21.11327  0.359
1996 Wolf PR, Ploegh HL. How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annual Review of Cell and Developmental Biology. 11: 267-306. PMID 8689559 DOI: 10.1146/Annurev.Cb.11.110195.001411  0.41
1996 Tourne S, van Santen HM, van Roon M, Berns A, Benoist C, Mathis D, Ploegh H. Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 93: 1464-9. PMID 8643655 DOI: 10.1073/Pnas.93.4.1464  0.394
1996 Wiertz EJ, Jones TR, Sun L, Bogyo M, Geuze HJ, Ploegh HL. The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol. Cell. 84: 769-79. PMID 8625414 DOI: 10.1016/S0092-8674(00)81054-5  0.574
1996 Riese RJ, Wolf PR, Brömme D, Natkin LR, Villadangos JA, Ploegh HL, Chapman HA. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading Immunity. 4: 357-366. PMID 8612130 DOI: 10.1016/S1074-7613(00)80249-6  0.398
1996 Miyazaki T, Wolf P, Tourne S, Waltzinger C, Dierich A, Barois N, Ploegh H, Benoist C, Mathis D. Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway. Cell. 84: 531-41. PMID 8598040 DOI: 10.1016/S0092-8674(00)81029-6  0.393
1996 Raposo G, van Santen HM, Leijendekker R, Geuze HJ, Ploegh HL. Misfolded major histocompatibility complex class I molecules accumulate in an expanded ER-Golgi intermediate compartment. The Journal of Cell Biology. 131: 1403-19. PMID 8522600 DOI: 10.1083/Jcb.131.6.1403  0.412
1996 Ljunggren H, Chambers B, Freland S, Glas R, Sandberg J, Kärre K, Tonegawa S, Ploegh HL, Kaer LV. Reactivity and specificity of CD8+ T cells in MHC class I deficient mice Human Immunology. 47: 110. DOI: 10.1016/0198-8859(96)85293-1  0.34
1995 Schumacher TN, Ploegh HL. Are MHC-bound peptides a nuisance for positive selection? Immunity. 1: 721-3. PMID 7895161 DOI: 10.1016/S1074-7613(94)80013-8  0.528
1995 Machold RP, Andrée S, Van Kaer L, Ljunggren HG, Ploegh HL. Peptide influences the folding and intracellular transport of free major histocompatibility complex class I heavy chains. The Journal of Experimental Medicine. 181: 1111-22. PMID 7869032 DOI: 10.1084/Jem.181.3.1111  0.335
1995 Ljunggren HG, Van Kaer L, Ashton-Rickardt PG, Tonegawa S, Ploegh HL. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. European Journal of Immunology. 25: 174-8. PMID 7843229 DOI: 10.1002/Eji.1830250129  0.305
1995 Martien van Santen H, Woolsey A, Rickardt PG, Van Kaer L, Baas EJ, Berns A, Tonegawa S, Ploegh HL. Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. The Journal of Experimental Medicine. 181: 787-92. PMID 7836931 DOI: 10.1084/Jem.181.2.787  0.39
1995 Hill A, Ploegh H. Getting the inside out: the transporter associated with antigen processing (TAP) and the presentation of viral antigen. Proceedings of the National Academy of Sciences of the United States of America. 92: 341-3. PMID 7831287 DOI: 10.1073/Pnas.92.2.341  0.418
1995 Schumacher TN, Kantesaria DV, Serreze DV, Roopenian DC, Ploegh HL. Transporters from H-2b, H-2d, H-2s, H-2k, and H-2g7 (NOD/Lt) haplotype translocate similar sets of peptides. Proceedings of the National Academy of Sciences of the United States of America. 91: 13004-8. PMID 7809164 DOI: 10.1073/Pnas.91.26.13004  0.546
1995 Hill A, Jugovic P, York I, Russ G, Bennink J, Yewdell J, Ploegh H, Johnson D. Herpes simplex virus turns off the TAP to evade host immunity. Nature. 375: 411-5. PMID 7760935 DOI: 10.1038/375411A0  0.398
1995 Peters PJ, Raposo G, Neefjes JJ, Oorschot V, Leijendekker RL, Geuze HJ, Ploegh HL. Major histocompatibility complex class II compartments in human B lymphoblastoid cells are distinct from early endosomes. The Journal of Experimental Medicine. 182: 325-34. PMID 7629497 DOI: 10.1084/Jem.182.2.325  0.542
1995 Ito K, Kobayashi T, Moriyama Y, Toshima K, Tatsuta K, Kakiuchi T, Futai M, Ploegh HL, Miwa K. Concanamycin B inhibits the expression of newly-synthesized MHC class II molecules on the cell surface. The Journal of Antibiotics. 48: 488-94. PMID 7622435 DOI: 10.7164/Antibiotics.48.488  0.359
1995 Ljunggren HG, Van Kaer L, Sabatine MS, Auchincloss H, Tonegawa S, Ploegh HL. MHC class I expression and CD8+ T cell development in TAP1/beta 2-microglobulin double mutant mice. International Immunology. 7: 975-84. PMID 7577806 DOI: 10.1093/Intimm/7.6.975  0.31
1995 Heemels M, Ploegh H. Generation, translocation, and presentation of MHC class I-restricted peptides. Annual Review of Biochemistry. 64: 463-491. PMID 7574490 DOI: 10.1146/Annurev.Bi.64.070195.002335  0.361
1995 Bénaroch P, Yilla M, Raposo G, Ito K, Miwa K, Geuze H, Ploegh H. How MHC class II molecules reach the endocytic pathway. The Embo Journal. 14: 37-49. DOI: 10.1002/J.1460-2075.1995.Tb06973.X  0.337
1994 Schumacher TN, Kantesaria DV, Heemels MT, Ashton-Rickardt PG, Shepherd JC, Fruh K, Yang Y, Peterson PA, Tonegawa S, Ploegh HL. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. The Journal of Experimental Medicine. 179: 533-40. PMID 8294864 DOI: 10.1084/Jem.179.2.533  0.569
1994 Cromme FV, Airey J, Heemels MT, Ploegh HL, Keating PJ, Stern PL, Meijer CJ, Walboomers JM. Loss of transporter protein, encoded by the TAP-1 gene, is highly correlated with loss of HLA expression in cervical carcinomas. The Journal of Experimental Medicine. 179: 335-40. PMID 8270878 DOI: 10.1084/Jem.179.1.335  0.395
1994 Heemels MT, Schumacher TN, Wonigeit K, Ploegh HL. Peptide translocation by variants of the transporter associated with antigen processing. Science (New York, N.Y.). 262: 2059-63. PMID 8266106 DOI: 10.1126/Science.8266106  0.566
1994 Tulp A, Verwoerd D, Dobberstein B, Ploegh HL, Pieters J. Isolation and characterization of the intracellular MHC class II compartment. Nature. 369: 120-6. PMID 8177317 DOI: 10.1038/369120A0  0.34
1994 Urban RG, Chicz RM, Lane WS, Strominger JL, Rehm A, Kenter MJ, UytdeHaag FG, Ploegh H, Uchanska-Ziegler B, Ziegler A. A subset of HLA-B27 molecules contains peptides much longer than nonamers. Proceedings of the National Academy of Sciences of the United States of America. 91: 1534-8. PMID 8108441 DOI: 10.1073/Pnas.91.4.1534  0.501
1994 Ljunggren HG, Van Kaer L, Ploegh HL, Tonegawa S. Altered natural killer cell repertoire in Tap-1 mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 6520-4. PMID 8022815 DOI: 10.1073/Pnas.91.14.6520  0.381
1994 Heemels M, Ploegh HL. Substrate specificity of allelic variants of the TAP peptide transporter Immunity. 1: 775-784. PMID 7895166 DOI: 10.1016/S1074-7613(94)80019-7  0.315
1994 Bijlmakers MJ, Benaroch P, Ploegh HL. Mapping functional regions in the lumenal domain of the class II-associated invariant chain. The Journal of Experimental Medicine. 180: 623-9. PMID 7519244 DOI: 10.1084/Jem.180.2.623  0.341
1994 Bijlmakers M, Benaroch P, Ploegh H. Assembly of HLA DR1 molecules translated in vitro: binding of peptide in the endoplasmic reticulum precludes association with invariant chain. The Embo Journal. 13: 2699-2707. DOI: 10.1002/J.1460-2075.1994.Tb06560.X  0.366
1993 Bijlmakers MJ, Neefjes JJ, Wojcik-Jacobs EH, Ploegh HL. The assembly of H2-Kb class I molecules translated in vitro requires oxidized glutathione and peptide. European Journal of Immunology. 23: 1305-13. PMID 8500526 DOI: 10.1002/Eji.1830230618  0.553
1993 Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus. Cell. 73: 1041-9. PMID 8500174 DOI: 10.1016/0092-8674(93)90281-T  0.579
1993 Rohren EM, Pease LR, Ploegh HL, Schumacher TN. Polymorphisms in pockets of major histocompatibility complex class I molecules influence peptide preference. The Journal of Experimental Medicine. 177: 1713-21. PMID 8496687 DOI: 10.1084/Jem.177.6.1713  0.556
1993 Neefjes JJ, Dierx J, Ploegh HL. The effect of anchor residue modifications on the stability of major histocompatibility complex class I-peptide interactions. European Journal of Immunology. 23: 840-5. PMID 8384560 DOI: 10.1002/Eji.1830230411  0.554
1993 Shepherd JC, Schumacher TN, Ashton-Rickardt PG, Imaeda S, Ploegh HL, Janeway CA, Tonegawa S. TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell. 74: 577-84. PMID 8348620 DOI: 10.1016/0092-8674(93)80058-M  0.604
1993 Abastado JP, Ojcius DM, Casrouge A, Yeh P, Schumacher TNM, Ploegh HL, Kourilsky P. A soluble, single-chain Kd molecule produced by yeast selects a peptide repertoire indistinguishable from that of cell-surface-associated Kd European Journal of Immunology. 23: 1776-1783. PMID 8344339 DOI: 10.1002/Eji.1830230807  0.358
1993 Ploegh H, Benaroch P. Immunology. MHC class II dimer of dimers. Nature. 364: 16-7. PMID 8316292 DOI: 10.1038/364016D0  0.312
1993 Ashton-Rickardt PG, Van Kaer L, Schumacher TN, Ploegh HL, Tonegawa S. Repertoire-determining role of peptide in the positive selection of CD8+ T cells. Immunological Reviews. 135: 157-82. PMID 8282312 DOI: 10.1111/J.1600-065X.1993.Tb00648.X  0.544
1993 Bijlmakers MJ, Ploegh HL. Putting together an MHC class I molecule. Current Opinion in Immunology. 5: 21-6. PMID 8095788 DOI: 10.1016/0952-7915(93)90076-5  0.371
1993 Viville S, Neefjes J, Lotteau V, Dierich A, Lemeur M, Ploegh H, Benoist C, Mathis D. Mice lacking the MHC class II-associated invariant chain. Cell. 72: 635-48. PMID 7679955 DOI: 10.1016/0092-8674(93)90081-Z  0.579
1992 Leeuwenberg JF, Tan A, Jeunhomme TM, Ploegh HL, Buurman WA. The ligand recognized by ELAM-1 on HL60 cells is not carried by N-linked oligosaccharides. European Journal of Immunology. 21: 3057-9. PMID 1721027 DOI: 10.1002/Eji.1830211225  0.304
1992 Neefjes JJ, Ploegh HL. Intracellular transport of MHC class II molecules. Immunology Today. 13: 179-84. PMID 1642756 DOI: 10.1016/0167-5699(92)90123-O  0.561
1992 Baas EJ, van Santen HM, Kleijmeer MJ, Geuze HJ, Peters PJ, Ploegh HL. Peptide-induced stabilization and intracellular localization of empty HLA class I complexes. The Journal of Experimental Medicine. 176: 147-56. PMID 1613456 DOI: 10.1084/Jem.176.1.147  0.392
1992 Faber ED, Oosting R, Neefjes JJ, Ploegh HL, Meijer DK. Distribution and elimination of the glycosidase inhibitors 1-deoxymannojirimycin and N-methyl-1-deoxynojirimycin in the rat in vivo. Pharmaceutical Research. 9: 1442-50. PMID 1475231 DOI: 10.1023/A:1015810913257  0.464
1992 Van Kaer L, Ashton-Rickardt PG, Ploegh HL, Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 71: 1205-14. PMID 1473153 DOI: 10.1016/S0092-8674(05)80068-6  0.382
1992 De Bruijn MLH, Nieland JD, Schumacher TNM, Ploegh HL, Kast WM, Melief CJM. Mechanisms of induction of primary virus-specific cytotoxic T lymphocyte responses European Journal of Immunology. 22: 3013-3020. PMID 1425925 DOI: 10.1002/Eji.1830221137  0.404
1992 Deres K, Schumacher TN, Wiesmüller KH, Stevanović S, Greiner G, Jung G, Ploegh HL. Preferred size of peptides that bind to H-2 Kb is sequence dependent. European Journal of Immunology. 22: 1603-8. PMID 1376267 DOI: 10.1002/Eji.1830220638  0.568
1992 Schumacher TN, Van Bleek GM, Heemels MT, Deres K, Li KW, Imarai M, Vernie LN, Nathenson SG, Ploegh HL. Synthetic peptide libraries in the determination of T cell epitopes and peptide binding specificity of class I molecules. European Journal of Immunology. 22: 1405-12. PMID 1376257 DOI: 10.1002/Eji.1830220612  0.566
1992 Guimezanes A, Schumacher TN, Ploegh HL, Schmitt-Verhulst AM. A viral peptide can mimic an endogenous peptide for allorecognition of a major histocompatibility complex class I product. European Journal of Immunology. 22: 1651-4. PMID 1318201 DOI: 10.1002/Eji.1830220647  0.567
1992 Neefjes JJ, Smit L, Gehrmann M, Ploegh HL. The fate of the three subunits of major histocompatibility complex class I molecules. European Journal of Immunology. 22: 1609-14. PMID 1318200 DOI: 10.1002/Eji.1830220639  0.563
1992 Neefjes JJ, Ploegh HL. Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes. The Embo Journal. 11: 411-6. PMID 1311249 DOI: 10.1002/J.1460-2075.1992.Tb05069.X  0.554
1991 Ljunggren HG, Oudshoorn-Snoek M, Masucci MG, Ploegh HL. High-resolution one-dimensional isoelectric focusing of mouse MHC class I antigens. Identification of natural and experimentally induced class I antigens. Immunogenetics. 32: 440-50. PMID 2272666 DOI: 10.1007/Bf00241639  0.348
1991 Stam NJ, Vroom TM, Peters PJ, Pastoors EB, Ploegh HL. HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. International Immunology. 2: 113-25. PMID 2088481 DOI: 10.1093/Intimm/2.2.113  0.326
1991 Andersson ML, Stam NJ, Klein G, Ploegh HL, Masucci MG. Aberrant expression of HLA class-I antigens in Burkitt lymphoma cells. International Journal of Cancer. 47: 544-50. PMID 1899854 DOI: 10.1002/Ijc.2910470412  0.34
1991 Peters PJ, Neefjes JJ, Oorschot V, Ploegh HL, Geuze HJ. Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments. Nature. 349: 669-76. PMID 1847504 DOI: 10.1038/349669A0  0.559
1991 Neefjes JJ, Schumacher TN, Ploegh HL. Assembly and intracellular transport of major histocompatibility complex molecules. Current Opinion in Cell Biology. 3: 601-9. PMID 1837724 DOI: 10.1016/0955-0674(91)90029-X  0.674
1991 Schumacher TN, De Bruijn ML, Vernie LN, Kast WM, Melief CJ, Neefjes JJ, Ploegh HL. Peptide selection by MHC class I molecules. Nature. 350: 703-6. PMID 1708852 DOI: 10.1038/350703A0  0.67
1991 De Bruijn MLH, Schumacher TNM, Nieland JD, Ploegh HL, Kast WM, Melief CJM. Peptide loading of empty major histocompatibility complex molecules on RMA-S cells allows the induction of primary cytotoxic T lymphocyte responses European Journal of Immunology. 21: 2963-2970. PMID 1660811 DOI: 10.1002/Eji.1830211210  0.39
1990 Eichholtz T, Alblas J, van Overveld M, Moolenaar W, Ploegh H. A pseudosubstrate peptide inhibits protein kinase C-mediated phosphorylation in permeabilized Rat-1 cells. Febs Letters. 261: 147-50. PMID 2307230 DOI: 10.1016/0014-5793(90)80657-5  0.336
1990 Neefjes JJ, De Bruijn ML, Boog CJ, Nieland JD, Boes J, Melief CJ, Ploegh HL. N-linked glycan modification on antigen-presenting cells restores an allospecific cytotoxic T cell response. The Journal of Experimental Medicine. 171: 583-8. PMID 2303788 DOI: 10.1084/Jem.171.2.583  0.535
1990 Neefjes JJ, Hengeveld T, Tol O, Ploegh HL. Intracellular interactions of transferrin and its receptor during biosynthesis. The Journal of Cell Biology. 111: 1383-92. PMID 2211816 DOI: 10.1083/Jcb.111.4.1383  0.5
1990 Schumacher TN, Heemels MT, Neefjes JJ, Kast WM, Melief CJ, Ploegh HL. Direct binding of peptide to empty MHC class I molecules on intact cells and in vitro. Cell. 62: 563-7. PMID 2199065 DOI: 10.1016/0092-8674(90)90020-F  0.676
1990 Neefjes JJ, Stollorz V, Peters PJ, Geuze HJ, Ploegh HL. The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route. Cell. 61: 171-83. PMID 2156628 DOI: 10.1016/0092-8674(90)90224-3  0.49
1990 NEEFJES JJ, PLOEGH HL. The Role of N-Linked Carbohydrates in Antigen Presentation Trends in Glycoscience and Glycotechnology. 2: 365-372. DOI: 10.4052/Tigg.2.365  0.498
1989 Boog CJ, Neefjes JJ, Boes J, Ploegh HL, Melief CJ. Specific immune responses restored by alteration in carbohydrate chains of surface molecules on antigen-presenting cells. European Journal of Immunology. 19: 537-42. PMID 2785048 DOI: 10.1002/Eji.1830190319  0.583
1989 Masucci MG, Stam NJ, Torsteinsdottir S, Neefjes JJ, Klein G, Ploegh HL. Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines. Cellular Immunology. 120: 396-400. PMID 2541930 DOI: 10.1016/0008-8749(89)90207-4  0.433
1989 Neefjes JJ, Lindhout J, Broxterman HJ, van der Marel GA, van Boom JH, Ploegh HL. Non-carrier-mediated uptake of the mannosidase I inhibitor 1-deoxymannojirimycin by K562 erythroleukemic cells. The Journal of Biological Chemistry. 264: 10271-5. PMID 2524494  0.429
1989 Doxiadis I, Krumbacher K, Neefjes JJ, Ploegh HL, Grosse-Wilde H. Biochemical evidence that the DLA-B locus codes for a class II determinant expressed on all canine peripheral blood lymphocytes. Experimental and Clinical Immunogenetics. 6: 219-24. PMID 2520676  0.477
1989 Rotteveel FT, Neefjes JJ, Ploegh HL, Lucas CJ. Influenza virus changes cell-surface glycoproteins including major histocompatibility complex determinants on lymphocytes. Human Immunology. 26: 199-213. PMID 2514159 DOI: 10.1016/0198-8859(89)90039-6  0.544
1989 BROXTERMAN HJG, NEEFJES JJ, VAN DER MAREL GA, PLOEGH HL, VAN BOOM JH. ChemInform Abstract: Synthesis of the Antibiotic 1,5-Dideoxy-1,5-imino-D-mannitol. Cheminform. 20. DOI: 10.1002/chin.198909319  0.368
1988 Bolscher JG, van der Bijl MM, Neefjes JJ, Hall A, Smets LA, Ploegh HL. Ras (proto)oncogene induces N-linked carbohydrate modification: temporal relationship with induction of invasive potential. The Embo Journal. 7: 3361-8. PMID 3061796 DOI: 10.1002/J.1460-2075.1988.Tb03208.X  0.488
1988 Neefjes JJ, Ploegh HL. Allele and locus-specific differences in cell surface expression and the association of HLA class I heavy chain with beta 2-microglobulin: differential effects of inhibition of glycosylation on class I subunit association. European Journal of Immunology. 18: 801-10. PMID 2967765 DOI: 10.1002/Eji.1830180522  0.546
1988 Neefjes JJ, Verkerk JM, Broxterman HJ, van der Marel GA, van Boom JH, Ploegh HL. Recycling glycoproteins do not return to the cis-Golgi. The Journal of Cell Biology. 107: 79-87. PMID 2839522 DOI: 10.1083/Jcb.107.1.79  0.515
1988 Broxterman HJG, Neefjes JJ, Van der Marel GA, Ploegh HL, Van Boom JH. Synthesis of the Antibiotic 1,5-dideoxy-1,5-imino-d-mannitol Journal of Carbohydrate Chemistry. 7: 593-603. DOI: 10.1080/07328308808057553  0.438
1988 BROXTERMAN HJG, VAN DER MAREL GA, NEEFJES JJ, PLOEGH HL, VAN BOOM JH. ChemInform Abstract: Synthesis of the Antibiotic 1,5-Dideoxy-1,5-imino-D-glucitol; Concomitant Formation of the D-Mannitol Analogue. Cheminform. 19. DOI: 10.1002/chin.198813351  0.368
1987 Rein RS, Seemann GH, Neefjes JJ, Hochstenbach FM, Stam NJ, Ploegh HL. Association with beta 2-microglobulin controls the expression of transfected human class I genes. Journal of Immunology (Baltimore, Md. : 1950). 138: 1178-83. PMID 3543123  0.471
1987 Güssow D, Rein RS, Meijer I, de Hoog W, Seemann GH, Hochstenbach FM, Ploegh HL. Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: evolutionary aspects. Immunogenetics. 25: 313-22. PMID 3032784 DOI: 10.1007/Bf00404424  0.361
1987 Gruters RA, Neefjes JJ, Tersmette M, de Goede RE, Tulp A, Huisman HG, Miedema F, Ploegh HL. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature. 330: 74-7. PMID 2959866 DOI: 10.1038/330074A0  0.497
1987 Kievits F, Ivanyi P, Krimpenfort P, Berns A, Ploegh HL. HLA-restricted recognition of viral antigens in HLA transgenic mice. Nature. 329: 447-449. PMID 2821399 DOI: 10.1038/329447A0  0.383
1987 Krimpenfort P, Rudenko G, Hochstenbach F, Guessow D, Berns A, Ploegh H. Crosses of two independently derived transgenic mice demonstrate functional complementation of the genes encoding heavy (HLA-B27) and light (beta 2-microglobulin) chains of HLA class I antigens. The Embo Journal. 6: 1673-1676. DOI: 10.1002/J.1460-2075.1987.Tb02416.X  0.338
1986 Neefjes JJ, Doxiadis I, Stam NJ, Beckers CJ, Ploegh HL. An analysis of class I antigens of man and other species by one-dimensional IEF and immunoblotting. Immunogenetics. 23: 164-71. PMID 3957414 DOI: 10.1007/Bf00373817  0.538
1986 Neefjes JJ, Hensen EJ, de Kroon TI, Ploegh HL. A biochemical characterization of feline MHC products: unusually high expression of class II antigens on peripheral blood lymphocytes. Immunogenetics. 23: 341-7. PMID 3458670 DOI: 10.1007/Bf00398799  0.547
1986 Neefjes JJ, Breur-Vriesendorp BS, van Seventer GA, Iványi P, Ploegh HL. An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes. Human Immunology. 16: 169-81. PMID 3087921 DOI: 10.1016/0198-8859(86)90046-7  0.469
1986 Seemann G, Rein R, Brown C, Ploegh H. Gene conversion-like mechanisms may generate polymorphism in human class I genes. The Embo Journal. 5: 547-552. DOI: 10.1002/J.1460-2075.1986.Tb04245.X  0.304
1983 Vasilov RG, Hahn A, Mölders H, van Rood JJ, Breuning M, Ploegh HL. Analysis of human class I antigens by two-dimensional gel electrophoresis. I. Polymorphism, evidence for additional (non-HLA-A, B, C) gene products, and identification of variant HLA-A, B antigens. Immunogenetics. 17: 333-56. PMID 6187677 DOI: 10.1007/BF00372454  0.493
1982 Orr HT, Bach FH, Ploegh HL, Strominger JL, Kavathas P, DeMars R. Use of HLA loss mutants to analyse the structure of the human major histocompatibility complex. Nature. 296: 454-6. PMID 7063041 DOI: 10.1038/296454A0  0.49
1981 Ploegh HL, Orr HT, Strominger JL. Major histocompatibility antigens: the human (HLA-A, -B, -C) and murine (H-2K, H-2D) class I molecules. Cell. 24: 287-99. PMID 7016338 DOI: 10.1016/0092-8674(81)90318-4  0.49
1980 Strominger JL, Engelhard VH, Guild BC, Kostyk TG, Lancet D, Lopez de Castro JA, Orr HT, Parham P, Ploegh HL, Pober JS. Complete primary structure of human histocompatibility antigen HLA-B7: evolutionary and functional implications. Current Topics in Developmental Biology. 14: 97-113. PMID 7460613 DOI: 10.1016/S0070-2153(08)60190-8  0.491
1980 Strominger JL, Orr HT, Parham P, Ploegh HL, Mann DL, Bilofsky H, Saroff HA, Wu TT, Kabat EA. An evaluation of the significance of amino acid sequence homologies in human histocompatibility antigens (HLA-A and HLA-B) with immunoglobulins and other proteins, using relatively short sequences. Scandinavian Journal of Immunology. 11: 573-92. PMID 7444380 DOI: 10.1111/J.1365-3083.1980.Tb00026.X  0.391
1980 Parham P, Ploegh HL. Molecular characterization of HLA-A, B homologues in owl monkeys and other nonhuman primates. Immunogenetics. 11: 131-43. PMID 7409864 DOI: 10.1007/Bf01567779  0.32
1980 Korman AJ, Ploegh HL, Kaufman JF, Owen MJ, Strominger JL. Cell-free synthesis and processing of the heavy and light chains of HLA-DR antigens. The Journal of Experimental Medicine. 152: 65s-82s. PMID 6967942  0.376
1980 Ploegh HL, Orr HT, Strominger JL. Molecular cloning of a human histocompatibility antigen cDNA fragment. Proceedings of the National Academy of Sciences of the United States of America. 77: 6081-5. PMID 6934534 DOI: 10.1073/Pnas.77.10.6081  0.48
1979 Ploegh HL, Cannon LE, Strominger JL. Cell-free translation of the mRNAs for the heavy and light chains of HLA-A and HLA-B antigens. Proceedings of the National Academy of Sciences of the United States of America. 76: 2273-7. PMID 287067 DOI: 10.1073/pnas.76.5.2273  0.437
1979 Orr HT, Lopez de Castro JA, Parham P, Ploegh HL, Strominger JL. Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proceedings of the National Academy of Sciences of the United States of America. 76: 4395-9. PMID 92029 DOI: 10.1073/Pnas.76.9.4395  0.463
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