K. C. Nicolaou - Publications

Affiliations: 
1989-2013 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2013- Rice University, Houston, TX 
Area:
chemistry, biology, and medicine of natural and designed molecules
Website:
http://chemistry.rice.edu/FacultyDetail.aspx?p=736D6ADC0CF5EA6C

327 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Nicolaou KC, Erande RD, Yin J, Vourloumis D, Aujay M, Sandoval J, Munneke S, Gavrilyuk J. Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates. Journal of the American Chemical Society. PMID 29381062 DOI: 10.1021/jacs.7b12692  0.72
2018 Nicolaou KC, Rigol S. A brief history of antibiotics and select advances in their synthesis. The Journal of Antibiotics. 71: 153-184. PMID 28676714 DOI: 10.1038/ja.2017.62  0.6
2017 Nicolaou KC, Pulukuri KK, Rigol S, Buchman M, Shah AA, Cen N, McCurry MD, Beabout K, Shamoo Y. Enantioselective Total Synthesis of Antibiotic CJ-16,264, Synthesis and Biological Evaluation of Designed Analogues, and Discovery of Highly Potent and Simpler Antibacterial Agents. Journal of the American Chemical Society. PMID 29064688 DOI: 10.1021/jacs.7b08749  1
2017 Nicolaou KC, Bellavance G, Buchman M, Pulukuri KK. Total Syntheses of Disorazoles A₁ and B₁ and Full Structural Elucidation of Disorazole B₁. Journal of the American Chemical Society. 139: 15636-15639. PMID 29064682 DOI: 10.1021/jacs.7b09843  0.6
2017 Nicolaou KC, Chen P, Zhu S, Cai Q, Erande RD, Li R, Sun H, Pulukuri KK, Rigol S, Aujay M, Sandoval J, Gavrilyuk J. Streamlined Total Synthesis of Trioxacarcins and Its Application to the Design, Synthesis, and Biological Evaluation of Analogues Thereof. Discovery of Simpler Designed and Potent Trioxacarcin Analogues. Journal of the American Chemical Society. PMID 29052423 DOI: 10.1021/jacs.7b08820  1
2017 Beabout K, McCurry MD, Mehta H, Shah AA, Pulukuri KK, Rigol S, Wang Y, Nicolaou KC, Shamoo Y. Experimental evolution of diverse strains as a method for the determination of biochemical mechanisms of action for novel pyrrolizidinone antibiotics. Acs Infectious Diseases. PMID 28942642 DOI: 10.1021/acsinfecdis.7b00135  1
2017 Nicolaou KC, Rhoades D, Wang Y, Bai R, Hamel E, Aujay M, Sandoval J, Gavrilyuk J. 12,13-Aziridinyl Epothilones. Stereoselective Synthesis of Trisubstituted Olefinic Bonds from Methyl Ketones and Heteroaromatic Phosphonates and Design, Synthesis, and Biological Evaluation of Potent Antitumor Agents. Journal of the American Chemical Society. PMID 28513142 DOI: 10.1021/jacs.7b02655  1
2017 Nicolaou KC, Liu G, Beabout K, McCurry MD, Shamoo Y. Asymmetric Alkylation of Anthrones, Enantioselective Total Synthesis of (-)- and (+)-Viridicatumtoxins B and Analogues Thereof: Absolute Configuration and Potent Antibacterial Agents. Journal of the American Chemical Society. PMID 28256128 DOI: 10.1021/jacs.6b12654  0.64
2016 Nicolaou KC, Rhoades D, Lamani M, Pattanayak MR, Kumar SM. Total Synthesis of Thailanstatin A. Journal of the American Chemical Society. PMID 27266914 DOI: 10.1021/jacs.6b04781  0.56
2016 Nicolaou KC, Wang Y, Lu M, Mandal D, Pattanayak MR, Yu R, Shah AA, Chen JS, Zhang H, Crawford JJ, Pasunoori L, Poudel YB, Chowdari NS, Pan C, Nazeer A, et al. Streamlined Total Synthesis of Uncialamycin and Its Application to the Synthesis of Designed Analogues for Biological Investigations. Journal of the American Chemical Society. PMID 27266267 DOI: 10.1021/jacs.6b04339  1
2016 Nicolaou KC, Pulukuri KK, Yu R, Rigol S, Heretsch P, Grove CI, Hale CR, ElMarrouni A. Total Synthesis of Δ(12) -Prostaglandin J3 : Evolution of Synthetic Strategies to a Streamlined Process. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27187634 DOI: 10.1002/chem.201601449  1
2016 Nicolaou KC, Pulukuri KK, Rigol S, Heretsch P, Yu R, Grove CI, Hale CR, ElMarrouni A, Fetz V, Brönstrup M, Aujay M, Sandoval J, Gavrilyuk J. Synthesis and Biological Investigation of Δ(12)-Prostaglandin J3 (Δ(12)-PGJ3) Analogues and Related Compounds. Journal of the American Chemical Society. PMID 27171618 DOI: 10.1021/jacs.6b02075  1
2016 He Y, Agarwal PK, Kiran IN, Yu R, Cao B, Zou C, Zhou X, Xu H, Xu B, Zhu L, Lan Y, Nicolaou KC. Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27113382 DOI: 10.1002/chem.201601471  1
2016 Savva CG, Totokotsopoulos S, Nicolaou KC, Neophytou CM, Constantinou AI. Selective activation of TNFR1 and NF-κB inhibition by a novel biyouyanagin analogue promotes apoptosis in acute leukemia cells. Bmc Cancer. 16: 279. PMID 27098354 DOI: 10.1186/s12885-016-2310-5  0.48
2016 Smee DF, Evans WJ, Nicolaou KC, Tarbet EB, Day CW. Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds. Antiviral Research. PMID 27063860 DOI: 10.1016/j.antiviral.2016.04.003  1
2016 Nicolaou KC, Cai Q, Sun H, Qin B, Zhu S. Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C. Journal of the American Chemical Society. PMID 26910506 DOI: 10.1021/jacs.5b12687  1
2016 Nicolaou KC, Yin J, Mandal D, Erande RD, Klahn P, Jin M, Aujay M, Sandoval J, Gavrilyuk J, Vourloumis D. Total Synthesis and Biological Evaluation of Natural and Designed Tubulysins. Journal of the American Chemical Society. PMID 26829208 DOI: 10.1021/jacs.5b12557  1
2015 Nicolaou KC, Vourloumis D, Totokotsopoulos S, Papakyriakou A, Karsunky H, Fernando H, Gavrilyuk J, Webb D, Stepan AF. Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs. Chemmedchem. PMID 26585829 DOI: 10.1002/cmdc.201500510  1
2015 Nicolaou KC, Rhoades D, Wang Y, Totokotsopoulos S, Bai R, Hamel E. Synthesis and Biological Evaluation of Novel Epothilone B Side Chain Analogues. Chemmedchem. PMID 26447977 DOI: 10.1002/cmdc.201500401  1
2015 Nicolaou KC, Lu M, Chen P, Shah AA. Practical Synthesis of p- and o-Amino- and Methoxyphenolic Anthraquinones. Angewandte Chemie (International Ed. in English). 54: 12687-91. PMID 26332286 DOI: 10.1002/anie.201507007  1
2015 Nicolaou KC, Lu Z, Li R, Woods JR, Sohn TI. Total Synthesis of Shishijimicin A. Journal of the American Chemical Society. PMID 26133230 DOI: 10.1021/jacs.5b05575  1
2015 Nicolaou KC, Shah AA, Korman H, Khan T, Shi L, Worawalai W, Theodorakis EA. Total Synthesis and Structural Revision of Antibiotic CJ-16,264. Angewandte Chemie (International Ed. in English). PMID 26096055 DOI: 10.1002/anie.201504337  1
2015 Nicolaou KC, Nilewski C, Hale CR, Ahles CF, Chiu CA, Ebner C, ElMarrouni A, Yang L, Stiles K, Nagrath D. Synthesis and biological evaluation of dimeric furanoid macroheterocycles: discovery of new anticancer agents. Journal of the American Chemical Society. 137: 4766-70. PMID 25827338 DOI: 10.1021/jacs.5b00141  1
2015 Nicolaou KC, Cai Q, Qin B, Petersen MT, Mikkelsen RJ, Heretsch P. Total synthesis of trioxacarcin DC-45-A2. Angewandte Chemie (International Ed. in English). 54: 3074-8. PMID 25583408 DOI: 10.1002/anie.201410369  1
2015 Talapatra SK, Talapatra B, Nicolaou KC. Chemistry of plant natural products: Stereochemistry, conformation, synthesis, biology, and medicine Chemistry of Plant Natural Products: Stereochemistry, Conformation, Synthesis, Biology, and Medicine. 1-1180. DOI: 10.1007/978-3-642-45410-3  1
2014 Nicolaou KC, Heretsch P, Nakamura T, Rudo A, Murata M, Konoki K. Synthesis and biological evaluation of QRSTUVWXYZA' domains of maitotoxin. Journal of the American Chemical Society. 136: 16444-51. PMID 25374117 DOI: 10.1021/ja509829e  1
2014 Nicolaou KC, Hale CR, Nilewski C, Ioannidou HA, ElMarrouni A, Nilewski LG, Beabout K, Wang TT, Shamoo Y. Total synthesis of viridicatumtoxin B and analogues thereof: strategy evolution, structural revision, and biological evaluation. Journal of the American Chemical Society. 136: 12137-60. PMID 25317739 DOI: 10.1021/ja506472u  1
2014 Ferreiro SF, Vilariño N, Louzao MC, Nicolaou KC, Frederick MO, Botana LM. In vitro chronic effects on hERG channel caused by the marine biotoxin azaspiracid-2. Toxicon : Official Journal of the International Society On Toxinology. 91: 69-75. PMID 25286396 DOI: 10.1016/j.toxicon.2014.09.012  1
2014 Nicolaou KC. The chemistry-biology-medicine continuum and the drug discovery and development process in academia. Chemistry & Biology. 21: 1039-45. PMID 25237851 DOI: 10.1016/j.chembiol.2014.07.020  1
2014 Nicolaou KC, Shi L, Lu M, Pattanayak MR, Shah AA, Ioannidou HA, Lamani M. Total synthesis of myceliothermophins C, D, and E. Angewandte Chemie (International Ed. in English). 53: 10970-4. PMID 25163463 DOI: 10.1002/anie.201406815  1
2014 Nicolaou KC, Heretsch P, ElMarrouni A, Hale CR, Pulukuri KK, Kudva AK, Narayan V, Prabhu KS. Total synthesis of Δ¹²-prostaglandin J₃, a highly potent and selective antileukemic agent. Angewandte Chemie (International Ed. in English). 53: 10443-7. PMID 25098181 DOI: 10.1002/anie.201404917  1
2014 Cheng C, Liu Y, Balasis ME, Garner TP, Li J, Simmons NL, Berndt N, Song H, Pan L, Qin Y, Nicolaou KC, Gavathiotis E, Sebti SM, Li R. Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim. Marine Drugs. 12: 4311-25. PMID 25076060 DOI: 10.3390/md12084311  1
2014 Nicolaou KC. Advancing the drug discovery and development process. Angewandte Chemie (International Ed. in English). 53: 9128-40. PMID 25045053 DOI: 10.1002/anie.201404761  1
2014 Nicolaou KC. Academic-industrial partnerships in drug discovery and development. Angewandte Chemie (International Ed. in English). 53: 4730-1. PMID 24706618 DOI: 10.1002/anie.201402816  1
2014 Nicolaou KC. Organic synthesis: the art and science of replicating the molecules of living nature and creating others like them in the laboratory. Proceedings. Mathematical, Physical, and Engineering Sciences / the Royal Society. 470: 20130690. PMID 24611027 DOI: 10.1098/rspa.2013.0690  1
2014 Cheng C, Liu Y, Balasis ME, Simmons NL, Li J, Song H, Pan L, Qin Y, Nicolaou KC, Sebti SM, Li R. Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim. Marine Drugs. 12: 1335-48. PMID 24608970 DOI: 10.3390/md12031335  1
2014 Rodríguez LP, Vilariño N, Louzao MC, Dickerson TJ, Nicolaou KC, Frederick MO, Botana LM. Microsphere-based immunoassay for the detection of azaspiracids. Analytical Biochemistry. 447: 58-63. PMID 24215909 DOI: 10.1016/j.ab.2013.10.035  1
2014 Ferreiro SF, Vilariño N, Carrera C, Louzao MC, Santamarina G, Cantalapiedra AG, Rodríguez LP, Cifuentes JM, Vieira AC, Nicolaou KC, Frederick MO, Botana LM. In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats. Archives of Toxicology. 88: 425-34. PMID 23934164 DOI: 10.1007/s00204-013-1115-4  1
2014 Nicolaou KC, Hale CRH. The endeavor of total synthesis and its impact on chemistry, biology and medicine National Science Review. 1: 233-252. DOI: 10.1093/nsr/nwu001  1
2013 Mishra OP, Simmons N, Tyagi S, Pietrofesa R, Shuvaev VV, Valiulin RA, Heretsch P, Nicolaou KC, Christofidou-Solomidou M. Synthesis and antioxidant evaluation of (S,S)- and (R,R)-secoisolariciresinol diglucosides (SDGs). Bioorganic & Medicinal Chemistry Letters. 23: 5325-8. PMID 23978651 DOI: 10.1016/j.bmcl.2013.07.062  1
2013 Nicolaou KC, Nilewski C, Hale CR, Ioannidou HA, ElMarrouni A, Koch LG. Total synthesis and structural revision of viridicatumtoxin B. Angewandte Chemie (International Ed. in English). 52: 8736-41. PMID 23893651 DOI: 10.1002/anie.201304691  1
2013 Nicolaou KC, Valiulin RA. Synthesis and biological evaluation of new paclitaxel analogs and discovery of potent antitumor agents. Organic & Biomolecular Chemistry. 11: 4154-63. PMID 23685867 DOI: 10.1039/c3ob40654g  1
2013 Nicolaou KC, Yu R, Shi L, Cai Q, Lu M, Heretsch P. General synthetic approach to functionalized dihydrooxepines. Organic Letters. 15: 1994-7. PMID 23550898 DOI: 10.1021/ol4006689  1
2013 Nicolaou KC. The emergence of the structure of the molecule and the art of its synthesis. Angewandte Chemie (International Ed. in English). 52: 131-46. PMID 23203813 DOI: 10.1002/anie.201207081  1
2013 Anderson HL, Lloyd-Jones GC, O'Brien P, Schofield CJ, Stephan DW, Nicolaou KC, Férey G, Meerholz K. New Fellows of the Royal Society: H. L. Anderson, G. C. Lloyd-Jones, P. O'Brien, C. J. Schofield, D. W. Stephan, K. C. Nicolaou / Lavoisier Medal: G. Férey / Richard Willstätter Lectureship: K. Meerholz Angewandte Chemie - International Edition. 52: 7071-7072. DOI: 10.1002/anie.201304013  1
2012 Nicolaou KC. How thiostrepton was made in the laboratory. Angewandte Chemie (International Ed. in English). 51: 12414-36. PMID 23208736 DOI: 10.1002/anie.201205576  1
2012 Nicolaou KC, Lu M, Totokotsopoulos S, Heretsch P, Giguère D, Sun YP, Sarlah D, Nguyen TH, Wolf IC, Smee DF, Day CW, Bopp S, Winzeler EA. Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. Journal of the American Chemical Society. 134: 17320-32. PMID 22978674 DOI: 10.1021/ja308429f  1
2012 Yin S, Kaluz S, Devi NS, Jabbar AA, de Noronha RG, Mun J, Zhang Z, Boreddy PR, Wang W, Wang Z, Abbruscato T, Chen Z, Olson JJ, Zhang R, Goodman MM, ... Nicolaou KC, et al. Arylsulfonamide KCN1 inhibits in vivo glioma growth and interferes with HIF signaling by disrupting HIF-1α interaction with cofactors p300/CBP. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 6623-33. PMID 22923450 DOI: 10.1158/1078-0432.CCR-12-0861  1
2012 Nicolaou KC, Hale CR, Nilewski C, Ioannidou HA. Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance. Chemical Society Reviews. 41: 5185-238. PMID 22743704 DOI: 10.1039/c2cs35116a  1
2012 Nicolaou KC, Hale CR, Nilewski C. A total synthesis trilogy: calicheamicin γ1(I), Taxol®, and brevetoxin A. Chemical Record (New York, N.Y.). 12: 407-41. PMID 22711588 DOI: 10.1002/tcr.201200005  1
2012 Koppaka V, Thompson DC, Chen Y, Ellermann M, Nicolaou KC, Juvonen RO, Petersen D, Deitrich RA, Hurley TD, Vasiliou V. Aldehyde dehydrogenase inhibitors: a comprehensive review of the pharmacology, mechanism of action, substrate specificity, and clinical application. Pharmacological Reviews. 64: 520-39. PMID 22544865 DOI: 10.1124/pr.111.005538  1
2012 Nicolaou KC, Valiulin RA, Pokorski JK, Chang V, Chen JS. Bio-inspired synthesis and biological evaluation of a colchicine-related compound library. Bioorganic & Medicinal Chemistry Letters. 22: 3776-80. PMID 22542017 DOI: 10.1016/j.bmcl.2012.04.007  1
2012 Bian M, Wang Z, Xiong X, Sun Y, Matera C, Nicolaou KC, Li A. Total syntheses of anominine and tubingensin A. Journal of the American Chemical Society. 134: 8078-81. PMID 22537293 DOI: 10.1021/ja302765m  1
2012 Nicolaou KC, Hale CR, Ebner C, Nilewski C, Ahles CF, Rhoades D. Synthesis of macroheterocycles through intramolecular oxidative coupling of furanoid β-ketoesters. Angewandte Chemie (International Ed. in English). 51: 4726-30. PMID 22489095 DOI: 10.1002/anie.201201538  1
2012 Nicolaou KC, Giguère D, Totokotsopoulos S, Sun YP. A practical sulfenylation of 2,5-diketopiperazines. Angewandte Chemie (International Ed. in English). 51: 728-32. PMID 22162254 DOI: 10.1002/anie.201107623  1
2012 Wang Q, Zhu JP, Nicolaou KC, Wong HNC, Li WD. Total Synthesis of Natural Products and the Synergy with Synthetic Methodology Organic Chemistry - Breakthroughs and Perspectives. 33-79. DOI: 10.1002/9783527664801.ch2  1
2011 Nicolaou KC, Sun YP, Sarlah D, Zhan W, Wu TR. Bioinspired synthesis of hirsutellones A, B, and C. Organic Letters. 13: 5708-10. PMID 21913732 DOI: 10.1021/ol202239u  1
2011 Nicolaou KC, Ellery SP, Rivas F, Saye K, Rogers E, Workinger TJ, Schallenberger M, Tawatao R, Montero A, Hessell A, Romesberg F, Carson D, Burton D. Synthesis and biological evaluation of 2',4'- and 3',4'-bridged nucleoside analogues. Bioorganic & Medicinal Chemistry. 19: 5648-69. PMID 21840722 DOI: 10.1016/j.bmc.2011.07.022  1
2011 Tan C, de Noronha RG, Devi NS, Jabbar AA, Kaluz S, Liu Y, Mooring SR, Nicolaou KC, Wang B, Van Meir EG. Sulfonamides as a new scaffold for hypoxia inducible factor pathway inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5528-32. PMID 21831638 DOI: 10.1016/j.bmcl.2011.06.099  1
2011 Nicolaou KC, Kiappes JL, Tian W, Gondi VB, Becker J. Synthesis of the carboline disaccharide domain of shishijimicin A. Organic Letters. 13: 3924-7. PMID 21711032 DOI: 10.1021/ol201444t  1
2011 Nicolaou KC, Aversa RJ. Maitotoxin: An Inspiration for Synthesis. Israel Journal of Chemistry. 51: 359-377. PMID 21709816 DOI: 10.1002/ijch.201100003  1
2011 Nicolaou KC, Totokotsopoulos S, Giguère D, Sun YP, Sarlah D. Total synthesis of epicoccin G. Journal of the American Chemical Society. 133: 8150-3. PMID 21548595 DOI: 10.1021/ja2032635  1
2011 Nicolaou KC, Simmons NL, Ying Y, Heretsch PM, Chen JS. Enantioselective dichlorination of allylic alcohols. Journal of the American Chemical Society. 133: 8134-7. PMID 21542622 DOI: 10.1021/ja202555m  1
2011 Nicolaou KC, Adsool VA, Hale CR. An expedient synthesis of a functionalized core structure of bielschowskysin. Angewandte Chemie (International Ed. in English). 50: 5149-52. PMID 21523870 DOI: 10.1002/anie.201101360  1
2011 Nicolaou KC, Simmons NL, Chen JS, Haste NM, Nizet V. Total synthesis and biological evaluation of marinopyrrole A and analogues. Tetrahedron Letters. 52: 2041-2043. PMID 21499535 DOI: 10.1016/j.tetlet.2010.09.059  1
2011 Saielli G, Nicolaou KC, Ortiz A, Zhang H, Bagno A. Addressing the stereochemistry of complex organic molecules by density functional theory-NMR: vannusal B in retrospective. Journal of the American Chemical Society. 133: 6072-7. PMID 21438587 DOI: 10.1021/ja201108a  1
2011 Wenzel M, Patra M, Albrecht D, Chen DY, Nicolaou KC, Metzler-Nolte N, Bandow JE. Proteomic signature of fatty acid biosynthesis inhibition available for in vivo mechanism-of-action studies. Antimicrobial Agents and Chemotherapy. 55: 2590-6. PMID 21383089 DOI: 10.1128/AAC.00078-11  1
2011 Nicolaou KC, Jiang X, Lindsay-Scott PJ, Corbu A, Yamashiro S, Bacconi A, Fowler VM. Total synthesis and biological evaluation of monorhizopodin and 16-epi-monorhizopodin. Angewandte Chemie (International Ed. in English). 50: 1139-44. PMID 21268213 DOI: 10.1002/anie.201006780  1
2011 Nicolaou KC, Sanchini S, Sarlah D, Lu G, Wu TR, Nomura DK, Cravatt BF, Cubitt B, de la Torre JC, Hessell AJ, Burton DR. Design, synthesis, and biological evaluation of a biyouyanagin compound library. Proceedings of the National Academy of Sciences of the United States of America. 108: 6715-20. PMID 21245351 DOI: 10.1073/pnas.1015258108  1
2011 Nicolaou KC, Baker TM, Nakamura T. Synthesis of the WXYZA' domain of maitotoxin. Journal of the American Chemical Society. 133: 220-6. PMID 21166430 DOI: 10.1021/ja109533y  1
2011 Nicolaou KC, Seo JH, Nakamura T, Aversa RJ. Synthesis of the C'D'E'F' domain of maitotoxin. Journal of the American Chemical Society. 133: 214-9. PMID 21166429 DOI: 10.1021/ja109531d  1
2011 Nicolaou KC. Invigorating education. Angewandte Chemie (International Ed. in English). 50: 63-74. PMID 21132824 DOI: 10.1002/anie.201005094  1
2010 Nicolaou KC, Wang J, Tang Y, Botta L. Total synthesis of sporolide B and 9-epi-sporolide B. Journal of the American Chemical Society. 132: 11350-63. PMID 20698702 DOI: 10.1021/ja1048994  1
2010 Nicolaou KC, Gelin CF, Seo JH, Huang Z, Umezawa T. Synthesis of the QRSTU domain of maitotoxin and its 85-epi- and 86-epi-diastereoisomers. Journal of the American Chemical Society. 132: 9900-7. PMID 20666400 DOI: 10.1021/ja103708j  1
2010 Nicolaou KC, Sun YP, Korman H, Sarlah D. Asymmetric total synthesis of cylindrocyclophanes A and F through cyclodimerization and a Ramberg-Bäcklund reaction. Angewandte Chemie (International Ed. in English). 49: 5875-8. PMID 20623817 DOI: 10.1002/anie.201003500  1
2010 Nicolaou KC, Sanchini S, Wu TR, Sarlah D. Total synthesis and structural revision of biyouyanagin B. Chemistry (Weinheim An Der Bergstrasse, Germany). 16: 7678-82. PMID 20572192 DOI: 10.1002/chem.201001474  1
2010 Nicolaou KC, Kang Q, Ng SY, Chen DY. Total synthesis of englerin A. Journal of the American Chemical Society. 132: 8219-22. PMID 20496885 DOI: 10.1021/ja102927n  1
2010 Nicolaou KC, Kang Q, Wu TR, Lim CS, Chen DY. Total synthesis and biological evaluation of the resveratrol-derived polyphenol natural products hopeanol and hopeahainol A. Journal of the American Chemical Society. 132: 7540-8. PMID 20462209 DOI: 10.1021/ja102623j  1
2010 Nicolaou KC, Ortiz A, Zhang H, Dagneau P, Lanver A, Jennings MP, Arseniyadis S, Faraoni R, Lizos DE. Total synthesis and structural revision of vannusals A and B: synthesis of the originally assigned structure of vannusal B. Journal of the American Chemical Society. 132: 7138-52. PMID 20443561 DOI: 10.1021/ja100740t  1
2010 Nicolaou KC, Ortiz A, Zhang H, Guella G. Total synthesis and structural revision of vannusals A and B: synthesis of the true structures of vannusals A and B. Journal of the American Chemical Society. 132: 7153-76. PMID 20443558 DOI: 10.1021/ja100742b  1
2010 Nicolaou KC, Aversa RJ, Jin J, Rivas F. Synthesis of the ABCDEFG ring system of maitotoxin. Journal of the American Chemical Society. 132: 6855-61. PMID 20415445 DOI: 10.1021/ja102260q  1
2010 Nicolaou KC, Adsool VA, Hale CR. An expedient procedure for the oxidative cleavage of olefinic bonds with PhI(OAc)2, NMO, and catalytic OsO4. Organic Letters. 12: 1552-5. PMID 20192259 DOI: 10.1021/ol100290a  1
2010 Nicolaou KC, Ding H, Richard JA, Chen DY. Total synthesis of echinopines A and B. Journal of the American Chemical Society. 132: 3815-8. PMID 20184316 DOI: 10.1021/ja9093988  1
2010 Cao Z, LePage KT, Frederick MO, Nicolaou KC, Murray TF. Involvement of caspase activation in azaspiracid-induced neurotoxicity in neocortical neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. 114: 323-34. PMID 20047973 DOI: 10.1093/toxsci/kfp312  1
2010 Hayden AE, Paton RS, Becker J, Lim YH, Nicolaou KC, Houk KN. Origins of regioselectivity of Diels-Alder reactions for the synthesis of bisanthraquinone antibiotic BE-43472B. The Journal of Organic Chemistry. 75: 922-8. PMID 20027998 DOI: 10.1021/jo902572y  1
2010 Nicolaou KC, Dong L, Deng L, Talbot AC, Chen DY. Synthesis of functionalized maoecrystal V core structures. Chemical Communications (Cambridge, England). 46: 70-2. PMID 20024296 DOI: 10.1039/b917045f  1
2010 Vale C, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons. Toxicological Sciences : An Official Journal of the Society of Toxicology. 113: 158-68. PMID 19815690 DOI: 10.1093/toxsci/kfp246  1
2009 Jeso V, Nicolaou KC. Total Synthesis of Tovophyllin B. Tetrahedron Letters. 50: 1161-1163. PMID 20161287 DOI: 10.1016/j.tetlet.2008.12.096  1
2009 Nicolaou KC, Harrison ST, Chen JS. Discoveries from the Abyss: The Abyssomicins and Their Total Synthesis. Synthesis. 2009: 33-42. PMID 20047014 DOI: 10.1055/s-0028-1083259  1
2009 Starosta AL, Qin H, Mikolajka A, Leung GY, Schwinghammer K, Nicolaou KC, Chen DY, Cooperman BS, Wilson DN. Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chemistry & Biology. 16: 1087-96. PMID 19875082 DOI: 10.1016/j.chembiol.2009.09.016  1
2009 Nicolaou KC, Li A, Edmonds DJ, Tria GS, Ellery SP. Total synthesis of platensimycin and related natural products. Journal of the American Chemical Society. 131: 16905-18. PMID 19874023 DOI: 10.1021/ja9068003  1
2009 Nicolaou KC, Chen JS. The art of total synthesis through cascade reactions. Chemical Society Reviews. 38: 2993-3009. PMID 19847336 DOI: 10.1039/b903290h  1
2009 Cee VJ, Chen DY, Lee MR, Nicolaou KC. Cortistatin A is a high-affinity ligand of protein kinases ROCK, CDK8, and CDK11. Angewandte Chemie (International Ed. in English). 48: 8952-7. PMID 19844931 DOI: 10.1002/anie.200904778  1
2009 Nicolaou KC, Tria GS, Edmonds DJ, Kar M. Total syntheses of (+/-)-platencin and (-)-platencin. Journal of the American Chemical Society. 131: 15909-17. PMID 19824676 DOI: 10.1021/ja906801g  1
2009 Narita T, Yin S, Gelin CF, Moreno CS, Yepes M, Nicolaou KC, Van Meir EG. Identification of a novel small molecule HIF-1alpha translation inhibitor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 6128-36. PMID 19789328 DOI: 10.1158/1078-0432.CCR-08-3180  1
2009 Nicolaou KC, Becker J, Lim YH, Lemire A, Neubauer T, Montero A. Total synthesis and biological evaluation of (+)- and (-)-bisanthraquinone antibiotic BE-43472B and related compounds. Journal of the American Chemical Society. 131: 14812-26. PMID 19778008 DOI: 10.1021/ja9073694  1
2009 Nicolaou KC, Dalby SM, Li S, Suzuki T, Chen DY. Total synthesis of (+)-haplophytine. Angewandte Chemie (International Ed. in English). 48: 7616-20. PMID 19746386 DOI: 10.1002/anie.200904588  1
2009 Nicolaou KC, Peng XS, Sun YP, Polet D, Zou B, Lim CS, Chen DY. Total synthesis and biological evaluation of cortistatins A and J and analogues thereof. Journal of the American Chemical Society. 131: 10587-97. PMID 19722632 DOI: 10.1021/ja902939t  1
2009 Nicolaou KC, Ellery SP, Chen JS. Samarium diiodide mediated reactions in total synthesis. Angewandte Chemie (International Ed. in English). 48: 7140-65. PMID 19714695 DOI: 10.1002/anie.200902151  1
2009 Nicolaou KC, Sarlah D, Wu TR, Zhan W. Total synthesis of hirsutellone B. Angewandte Chemie (International Ed. in English). 48: 6870-4. PMID 19685548 DOI: 10.1002/anie.200903382  1
2009 Hirschmann RF, Nicolaou KC, Angeles AR, Chen JS, Smith AB. The beta-D-glucose scaffold as a beta-turn mimetic. Accounts of Chemical Research. 42: 1511-20. PMID 19624154 DOI: 10.1021/ar900020x  1
2009 Nicolaou KC, Li A, Ellery SP, Edmonds DJ. Rhodium-catalyzed asymmetric enyne cycloisomerization of terminal alkynes and formal total synthesis of (-)-platensimycin. Angewandte Chemie (International Ed. in English). 48: 6293-5. PMID 19606433 DOI: 10.1002/anie.200901992  1
2009 Nicolaou KC, Nold AL, Li H. Synthesis of the monomeric unit of the lomaiviticin aglycon. Angewandte Chemie (International Ed. in English). 48: 5860-3. PMID 19575434 DOI: 10.1002/anie.200902509  1
2009 Nicolaou KC, Ortiz A, Zhang H. The true structures of the vannusals, part 2: Total synthesis and revised structure of vannusal B. Angewandte Chemie (International Ed. in English). 48: 5648-52. PMID 19562817 DOI: 10.1002/anie.200902029  1
2009 Nicolaou KC, Zhang H, Ortiz A. The true structures of the vannusals, part 1: Initial forays into suspected structures and intelligence gathering. Angewandte Chemie (International Ed. in English). 48: 5642-7. PMID 19562816 DOI: 10.1002/anie.200902028  1
2009 Frederick MO, De Lamo Marin S, Janda KD, Nicolaou KC, Dickerson TJ. Monoclonal antibodies with orthogonal azaspiracid epitopes. Chembiochem : a European Journal of Chemical Biology. 10: 1625-9. PMID 19492388 DOI: 10.1002/cbic.200900201  1
2009 Nicolaou KC, Wu TR, Kang Q, Chen DY. Total synthesis of hopeahainol A and hopeanol. Angewandte Chemie (International Ed. in English). 48: 3440-3. PMID 19280619 DOI: 10.1002/anie.200900438  1
2009 Nicolaou KC, Krasovskiy A, Majumder U, Trépanier VE, Chen DY. New synthetic technologies for the construction of heterocycles and tryptamines. Journal of the American Chemical Society. 131: 3690-9. PMID 19243142 DOI: 10.1021/ja808692j  1
2009 Nicolaou KC, Tang Y, Wang J. Total synthesis of sporolide B. Angewandte Chemie (International Ed. in English). 48: 3449-53. PMID 19241430 DOI: 10.1002/anie.200900264  1
2009 Nicolaou KC, Lim YH, Becker J. Total synthesis and absolute configuration of the bisanthraquinone antibiotic BE-43472B. Angewandte Chemie (International Ed. in English). 48: 3444-8. PMID 19235819 DOI: 10.1002/anie.200900058  1
2009 Nicolaou KC, Reingruber R, Sarlah D, Bräse S. Enantioselective intramolecular Friedel-Crafts-type alpha-arylation of aldehydes. Journal of the American Chemical Society. 131: 2086-7. PMID 19173649 DOI: 10.1021/ja809405c  1
2009 Nicolaou KC. Inspirations, discoveries, and future perspectives in total synthesis. The Journal of Organic Chemistry. 74: 951-72. PMID 19152273 DOI: 10.1021/jo802351b  1
2009 Nicolaou KC, Chen JS, Edmonds DJ, Estrada AA. Recent advances in the chemistry and biology of naturally occurring antibiotics. Angewandte Chemie (International Ed. in English). 48: 660-719. PMID 19130444 DOI: 10.1002/anie.200801695  1
2009 Nicolaou KC, Chen JS, Dalby SM. From nature to the laboratory and into the clinic. Bioorganic & Medicinal Chemistry. 17: 2290-303. PMID 19028103 DOI: 10.1016/j.bmc.2008.10.089  1
2009 Nicolaou KC, Reingruber R, Sarlah D, Bräse S. Enantioselective Intramolecular Friedel-Crafts-Type α-Arylation of Aldehydes (Journal of the American Chemical Society (2009) 131 (2086-2087)) Journal of the American Chemical Society. 131: 6640.  1
2008 Nicolaou KC, Lister T, Denton RM, Gelin CF. Total synthesis of atrochamins F, H, I, and J through cascade reactions. Tetrahedron. 64: 4736-4757. PMID 19461992 DOI: 10.1016/j.tet.2008.02.108  1
2008 Nicolaou KC, Dalby SM, Majumder U. A concise asymmetric total synthesis of aspidophytine. Journal of the American Chemical Society. 130: 14942-3. PMID 18855359 DOI: 10.1021/ja806176w  1
2008 Nicolaou KC, Zhang H, Ortiz A, Dagneau P. Total synthesis of the originally assigned structure of vannusal B. Angewandte Chemie (International Ed. in English). 47: 8605-10. PMID 18850598 DOI: 10.1002/anie.200804228  1
2008 Nicolaou KC, Stepan AF, Lister T, Li A, Montero A, Tria GS, Turner CI, Tang Y, Wang J, Denton RM, Edmonds DJ. Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity. Journal of the American Chemical Society. 130: 13110-9. PMID 18771264 DOI: 10.1021/ja8044376  1
2008 Nicolaou KC, Frederick MO, Aversa RJ. The continuing saga of the marine polyether biotoxins. Angewandte Chemie (International Ed. in English). 47: 7182-225. PMID 18763702 DOI: 10.1002/anie.200801696  1
2008 Vilariño N, Nicolaou KC, Frederick MO, Cagide E, Alfonso C, Alonso E, Vieytes MR, Botana LM. Azaspiracid substituent at C1 is relevant to in vitro toxicity. Chemical Research in Toxicology. 21: 1823-31. PMID 18707138 DOI: 10.1021/tx800165c  1
2008 Nicolaou KC, Sun YP, Peng XS, Polet D, Chen DY. Total synthesis of (+)-cortistatin A. Angewandte Chemie (International Ed. in English). 47: 7310-3. PMID 18704899 DOI: 10.1002/anie.200803550  1
2008 Nicolaou KC, Toh QY, Chen DY. An expedient asymmetric synthesis of platencin. Journal of the American Chemical Society. 130: 11292-3. PMID 18665593 DOI: 10.1021/ja804588r  1
2008 Nicolaou KC, Li A. Total syntheses and structural revision of alpha- and beta-diversonolic esters and total syntheses of diversonol and blennolide C. Angewandte Chemie (International Ed. in English). 47: 6579-82. PMID 18651685 DOI: 10.1002/anie.200802632  1
2008 Nicolaou KC, Wu TR, Sarlah D, Shaw DM, Rowcliffe E, Burton DR. Total synthesis, revised structure, and biological evaluation of biyouyanagin A and analogues thereof. Journal of the American Chemical Society. 130: 11114-21. PMID 18646750 DOI: 10.1021/ja802805c  1
2008 Nicolaou KC, Leung GY, Dethe DH, Guduru R, Sun YP, Lim CS, Chen DY. Chemical synthesis and biological evaluation of palmerolide A analogues. Journal of the American Chemical Society. 130: 10019-23. PMID 18598030 DOI: 10.1021/ja802803e  1
2008 Nicolaou KC, Dethe DH, Chen DY. Total syntheses of amythiamicins A, B and C. Chemical Communications (Cambridge, England). 2632-4. PMID 18535690 DOI: 10.1039/b805069b  1
2008 Vale C, Wandscheer C, Nicolaou KC, Frederick MO, Alfonso C, Vieytes MR, Botana LM. Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: involvement of the c-Jun N-terminal kinase. Journal of Neuroscience Research. 86: 2952-62. PMID 18500761 DOI: 10.1002/jnr.21731  1
2008 Nicolaou KC, Frederick MO, Burtoloso AC, Denton RM, Rivas F, Cole KP, Aversa RJ, Gibe R, Umezawa T, Suzuki T. Chemical Synthesis of the GHIJKLMNO Ring System of Maitotoxin. Journal of the American Chemical Society. 130: 7466-76. PMID 18481856 DOI: 10.1021/ja801139f  1
2008 Nicolaou KC, Krasovskiy A, Trépanier VE, Chen DY. An expedient strategy for the synthesis of tryptamines and other heterocycles. Angewandte Chemie (International Ed. in English). 47: 4217-20. PMID 18404758 DOI: 10.1002/anie.200800404  1
2008 Nicolaou KC, Sun YP, Guduru R, Banerji B, Chen DY. Total synthesis of the originally proposed and revised structures of palmerolide A and isomers thereof. Journal of the American Chemical Society. 130: 3633-44. PMID 18298117 DOI: 10.1021/ja710485n  1
2008 Nicolaou KC, Tria GS, Edmonds DJ. Total synthesis of platencin. Angewandte Chemie (International Ed. in English). 47: 1780-3. PMID 18246566 DOI: 10.1002/anie.200800066  1
2008 Nicolaou KC, Wang J, Tang Y. Synthesis of the sporolide ring framework through a cascade sequence involving an intramolecular [4+2] cycloaddition reaction of an o-quinone. Angewandte Chemie (International Ed. in English). 47: 1432-5. PMID 18205155 DOI: 10.1002/anie.200705334  1
2008 Nicolaou KC, Dethe DH, Leung GY, Zou B, Chen DY. Total synthesis of thiopeptide antibiotics GE2270A, GE2270T, and GE2270C1. Chemistry, An Asian Journal. 3: 413-29. PMID 18188863 DOI: 10.1002/asia.200700361  1
2008 Nicolaou KC, Pappo D, Tsang KY, Gibe R, Chen DY. A chiral pool based synthesis of platensimycin. Angewandte Chemie (International Ed. in English). 47: 944-6. PMID 18176919 DOI: 10.1002/anie.200705080  1
2008 Nicolaou KC, Chen JS, Zhang H, Montero A. Asymmetric synthesis and biological properties of uncialamycin and 26-epi-uncialamycin. Angewandte Chemie (International Ed. in English). 47: 185-9. PMID 18058881 DOI: 10.1002/anie.200704577  1
2008 Nicolaou KC, Chen JS. Total synthesis of complex heterocyclic natural products Pure and Applied Chemistry. 80: 727-742. DOI: 10.1351/pac200880040727  1
2008 Nicolaou KC, Toh QY, Chen DYK. An expedient asymmetric synthesis of platencin (Journal of the American Chemical Society (2008) 130, (11292-11293)) Journal of the American Chemical Society. 130: 14016. DOI: 10.1021/ja806849z  1
2008 Nicolaou KC. Free - That is my style Nachrichten Aus Der Chemie. 56: 1246-1248.  1
2008 Nicolaou KC. Chemistry, biology and medicine of natural products Epitheorese Klinikes Farmakologias Kai Farmakokinetikes. 26: 11.  1
2007 Nicolaou KC, Estrada AA, Freestone GC, Lee SH, Alvarez-Mico X. New synthetic technology for the construction of N-hydroxyindoles and synthesis of nocathiacin I model systems. Tetrahedron. 63: 6088-6114. PMID 20606766 DOI: 10.1016/j.tet.2007.03.072  1
2007 Nicolaou KC, Tang Y, Wang J, Stepan AF, Li A, Montero A. Total synthesis and antibacterial properties of carbaplatensimycin. Journal of the American Chemical Society. 129: 14850-1. PMID 17988130 DOI: 10.1021/ja076126e  1
2007 Vale C, Gómez-Limia B, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 20: 957-66. PMID 17982278 DOI: 10.1159/000110456  1
2007 Nicolaou KC, Cole KP, Frederick MO, Aversa RJ, Denton RM. Chemical synthesis of the GHIJK ring system and further experimental support for the originally assigned structure of maitotoxin. Angewandte Chemie (International Ed. in English). 46: 8875-9. PMID 17943950 DOI: 10.1002/anie.200703742  1
2007 Nicolaou KC, Lister T, Denton RM, Gelin CF. Cascade reactions involving formal [2+2] thermal cycloadditions: total synthesis of artochamins F, H, I, and J. Angewandte Chemie (International Ed. in English). 46: 7501-5. PMID 17768746 DOI: 10.1002/anie.200702363  1
2007 Nicolaou KC, Tang Y, Wang J. Formal synthesis of (+/-)-platensimycin. Chemical Communications (Cambridge, England). 1922-3. PMID 17695230  1
2007 Nicolaou KC, Li H, Nold AL, Pappo D, Lenzen A. Total synthesis of kinamycins C, F, and J. Journal of the American Chemical Society. 129: 10356-7. PMID 17676854 DOI: 10.1021/ja074297d  1
2007 Nicolaou KC, Guduru R, Sun YP, Banerji B, Chen DY. Total synthesis of the originally proposed and revised structures of palmerolide A. Angewandte Chemie (International Ed. in English). 46: 5896-900. PMID 17600809 DOI: 10.1002/anie.200702243  1
2007 Nicolaou KC, Majumder U, Roche SP, Chen DY. Construction of the "left domain" of haplophytine. Angewandte Chemie (International Ed. in English). 46: 4715-8. PMID 17559182 DOI: 10.1002/anie.200701947  1
2007 Nicolaou KC, Sarlah D, Shaw DM. Total synthesis and revised structure of biyouyanagin A. Angewandte Chemie (International Ed. in English). 46: 4708-11. PMID 17523208 DOI: 10.1002/anie.200701552  1
2007 Nicolaou KC, Lister T, Denton RM, Montero A, Edmonds DJ. Adamantaplatensimycin: a bioactive analogue of platensimycin. Angewandte Chemie (International Ed. in English). 46: 4712-4. PMID 17514775 DOI: 10.1002/anie.200701548  1
2007 Nicolaou KC, Zhang H, Chen JS, Crawford JJ, Pasunoori L. Total synthesis and stereochemistry of uncialamycin. Angewandte Chemie (International Ed. in English). 46: 4704-7. PMID 17497617 DOI: 10.1002/anie.200700917  1
2007 Vilariño N, Nicolaou KC, Frederick MO, Vieytes MR, Botana LM. Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells. Biochemical Pharmacology. 74: 327-35. PMID 17485074 DOI: 10.1016/j.bcp.2007.04.004  1
2007 Nicolaou KC, Frederick MO. On the structure of maitotoxin. Angewandte Chemie (International Ed. in English). 46: 5278-82. PMID 17469088 DOI: 10.1002/anie.200604656  1
2007 Nicolaou KC, Edmonds DJ, Li A, Tria GS. Asymmetric total syntheses of platensimycin. Angewandte Chemie (International Ed. in English). 46: 3942-5. PMID 17444571 DOI: 10.1002/anie.200700586  1
2007 Nicolaou KC, Lim YH, Piper JL, Papageorgiou CD. Total syntheses of 2,2'-epi-cytoskyrin A, rugulosin, and the alleged structure of rugulin. Journal of the American Chemical Society. 129: 4001-13. PMID 17355133 DOI: 10.1021/ja0685708  1
2007 Altmann KH, Pfeiffer B, Arseniyadis S, Pratt BA, Nicolaou KC. The chemistry and biology of epothilones--the wheel keeps turning. Chemmedchem. 2: 396-423. PMID 17340668 DOI: 10.1002/cmdc.200600206  1
2007 Nicolaou KC, Nold AL, Milburn RR, Schindler CS, Cole KP, Yamaguchi J. Total synthesis of marinomycins A-C and of their monomeric counterparts monomarinomycin A and iso-monomarinomycin A. Journal of the American Chemical Society. 129: 1760-8. PMID 17249678 DOI: 10.1021/ja068053p  1
2007 Vale C, Nicolaou KC, Frederick MO, Gómez-Limia B, Alfonso A, Vieytes MR, Botana LM. Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study. Journal of Medicinal Chemistry. 50: 356-63. PMID 17228878 DOI: 10.1021/jm061063g  1
2007 Nicolaou KC, Harrison ST. Total synthesis of abyssomicin C, atrop-abyssomicin C, and abyssomicin D: implications for natural origins of atrop-abyssomicin C. Journal of the American Chemical Society. 129: 429-40. PMID 17212423 DOI: 10.1021/ja067083p  1
2007 Nicolaou KC, Tang Y, Wang J. Formal synthesis of (±)-platensimycin Chemical Communications. 1922-1923. DOI: 10.1039/b704589a  1
2007 Frederick MO, Cole KP, Petrovic G, Loizidou E, Nicolaou KC. Structural Assignment and Total Synthesis of Azaspiracid-1 Phycotoxins: Chemistry and Biochemistry. 297-309. DOI: 10.1002/9780470277874.ch16  1
2007 Nicolaou KC, Ortiz A, Denton RM. Metathesis reactions in the synthesis of complex molecules Chimica Oggi. 25: 70-76.  1
2006 Nicolaou KC, Frederick MO, Loizidou EZ, Petrovic G, Cole KP, Koftis TV, Yamada YM. Second-generation total synthesis of azaspiracids-1, -2, and -3. Chemistry, An Asian Journal. 1: 245-63. PMID 17441061 DOI: 10.1002/asia.200600059  1
2006 Vilariño N, Nicolaou KC, Frederick MO, Cagide E, Ares IR, Louzao MC, Vieytes MR, Botana LM. Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies Chemical Research in Toxicology. 19: 1459-1466. PMID 17112233 DOI: 10.1021/tx060131z  1
2006 Nicolaou KC, Edmonds DJ, Bulger PG. Cascade reactions in total synthesis Angewandte Chemie - International Edition. 45: 7134-7186. PMID 17075967 DOI: 10.1002/anie.200601872  1
2006 Nicolaou KC, Zou B, Dethe DH, Li DB, Chen DY. Total synthesis of antibiotics GE2270A and GE2270T. Angewandte Chemie (International Ed. in English). 45: 7786-92. PMID 17061302 DOI: 10.1002/anie.200602798  1
2006 Nicolaou KC, Nold AL, Milburn RR, Schindler CS. Total synthesis of marinomycins A-C. Angewandte Chemie (International Ed. in English). 45: 6527-32. PMID 16977657 DOI: 10.1002/anie.200601867  1
2006 Nicolaou KC, Pratt BA, Arseniyadis S, Wartmann M, O'Brate A, Giannakakou P. Molecular design and chemical synthesis of a highly potent epothilone Chemmedchem. 1: 41-44. PMID 16892332 DOI: 10.1002/cmdc.200500056  1
2006 Hamel E, Day BW, Miller JH, Jung MK, Northcote PT, Ghosh AK, Curran DP, Cushman M, Nicolaou KC, Paterson I, Sorensen EJ. Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly. Molecular Pharmacology. 70: 1555-64. PMID 16887932 DOI: 10.1124/mol.106.027847  1
2006 Nicolaou KC, Estrada AA, Sang HL, Freestone GC. Synthesis of highly substituted N-hydroxyindoles through 1,5-Addition of carbon nucleophiles to in situ generated unsaturated nitrones Angewandte Chemie - International Edition. 45: 5364-5368. PMID 16847981 DOI: 10.1002/anie.200601808  1
2006 Hayden AE, Xu H, Nicolaou KC, Houk KN. Origins of selectivity in pericyclic reaction cascades for the synthesis of gambogin and lateriflorone. Organic Letters. 8: 2989-92. PMID 16805534 DOI: 10.1021/ol060917o  1
2006 Alfonso A, Vieytes MR, Ofuji K, Satake M, Nicolaou KC, Frederick MO, Botana LM. Azaspiracids modulate intracellular pH levels in human lymphocytes Biochemical and Biophysical Research Communications. 346: 1091-1099. PMID 16793022 DOI: 10.1016/j.bbrc.2006.06.019  1
2006 Nicolaou KC, Bulger PG, Brenzovich WE. Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide i structures. Revised strategy and final stages Organic and Biomolecular Chemistry. 4: 2158-2183. PMID 16729127 DOI: 10.1039/b602021f  1
2006 Nicolaou KC, Brenzovich WE, Bulger PG, Francis TM. Synthesis of iso-epoxy-amphidinolide N and des-epoxy-caribenolide I structures. Initial forays. Organic & Biomolecular Chemistry. 4: 2119-57. PMID 16729126 DOI: 10.1039/b602020h  1
2006 Nicolaou KC, Harrison ST. Total synthesis of abyssomicin C and atrop-abyssomicin C. Angewandte Chemie (International Ed. in English). 45: 3256-60. PMID 16634106 DOI: 10.1002/anie.200601116  1
2006 Nicolaou KC, Lizos DE, Kim DW, Schlawe D, de Noronha RG, Longbottom DA, Rodriquez M, Bucci M, Cirino G. Total synthesis and biological evaluation of halipeptins A and D and analogues. Journal of the American Chemical Society. 128: 4460-70. PMID 16569024 DOI: 10.1021/ja060064v  1
2006 Nicolaou KC, Frederick MO, Petrovic G, Cole KP, Loizidou EZ. Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3. Angewandte Chemie (International Ed. in English). 45: 2609-15. PMID 16548033 DOI: 10.1002/anie.200600295  1
2006 Nicolaou KC, Koftis TV, Vyskocil S, Petrovic G, Tang W, Frederick MO, Chen DY, Li Y, Ling T, Yamada YM. Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1. Journal of the American Chemical Society. 128: 2859-72. PMID 16506764 DOI: 10.1021/ja054750q  1
2006 Nicolaou KC, Denton RM, Lenzen A, Edmonds DJ, Li A, Milburn RR, Harrison ST. Stereocontrolled synthesis of model core systems of lomaiviticins A and B. Angewandte Chemie (International Ed. in English). 45: 2076-81. PMID 16496276 DOI: 10.1002/anie.200504466  1
2006 Nicolaou KC, Chen DY, Li Y, Uesaka N, Petrovic G, Koftis TV, Bernal F, Frederick MO, Govindasamy M, Ling T, Pihko PM, Tang W, Vyskocil S. Total synthesis and structural elucidation of azaspiracid-1. Synthesis-based analysis of originally proposed structures and indication of their non-identity to the natural product. Journal of the American Chemical Society. 128: 2258-67. PMID 16478179 DOI: 10.1021/ja054748z  1
2006 Nicolaou KC, Pihko PM, Bernal F, Frederick MO, Qian W, Uesaka N, Diedrichs N, Hinrichs J, Koftis TV, Loizidou E, Petrovic G, Rodriquez M, Sarlah D, Zou N. Total synthesis and structural elucidation of azaspiracid-1. Construction of key building blocks for originally proposed structure. Journal of the American Chemical Society. 128: 2244-57. PMID 16478178 DOI: 10.1021/ja0547477  1
2006 Nicolaou KC, Xu H. Total synthesis of floresolide B and Delta(6,7)-Z-floresolide B. Chemical Communications (Cambridge, England). 600-2. PMID 16446822 DOI: 10.1039/b517385j  1
2006 Ito E, Frederick MO, Koftis TV, Tang W, Petrovic G, Ling T, Nicolaou KC. Structure toxicity relationships of synthetic azaspiracid-1 and analogs in mice Harmful Algae. 5: 586-591. DOI: 10.1016/j.hal.2005.11.005  1
2005 Nicolaou KC, Lim YH, Papageorgiou CD, Piper JL. Total synthesis of (+)-rugulosin and (+)-2,2'-epi-cytoskyrin A through cascade reactions. Angewandte Chemie (International Ed. in English). 44: 7917-21. PMID 16342134 DOI: 10.1002/anie.200503678  1
2005 Nicolaou KC, Zak M, Rahimipour S, Estrada AA, Lee SH, O'Brate A, Giannakakou P, Ghadiri MR. Discovery of a biologically active thiostrepton fragment. Journal of the American Chemical Society. 127: 15042-4. PMID 16248640 DOI: 10.1021/ja0552803  1
2005 Nicolaou KC. Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry Journal of Medicinal Chemistry. 48: 5613-5638. PMID 16134928 DOI: 10.1021/jm050524f  1
2005 Nicolaou KC, Mathison CJN. Synthesis of imides, N-acyl vinylogous carbamates and ureas, and nitriles by oxidation of amides and amines with dess-martin periodinane Angewandte Chemie - International Edition. 44: 5992-5997. PMID 16124020 DOI: 10.1002/anie.200501853  1
2005 Nicolaou KC, Papageorgiou CD, Piper JL, Chadha RK. The cytoskyrin cascade: a facile entry into cytoskyrin A, deoxyrubroskyrin, rugulin, skyrin, and flavoskyrin model systems. Angewandte Chemie (International Ed. in English). 44: 5846-51. PMID 16123947 DOI: 10.1002/anie.200502011  1
2005 Nicolaou KC. Joys of molecules. 1. Campaigns in total synthesis Journal of Organic Chemistry. 70: 7007-7027. PMID 16122219 DOI: 10.1021/jo050963m  1
2005 Nicolaou KC, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M. Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis Journal of the American Chemical Society. 127: 11176-11183. PMID 16076225 DOI: 10.1021/ja052934z  1
2005 Nicolaou KC, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA, Funke C, Zécri FJ, Bulat S. Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. Journal of the American Chemical Society. 127: 11159-75. PMID 16076224 DOI: 10.1021/ja0529337  1
2005 Nicolaou KC, Schlawe D, Kim DW, Longbottom DA, de Noronha RG, Lizos DE, Manam RR, Faulkner DJ. Total synthesis of halipeptins: isolation of halipeptin D and synthesis of oxazoline halipeptin analogues. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 6197-211. PMID 16075448 DOI: 10.1002/chem.200500624  1
2005 Nicolaou KC, Kim DW, Schlawe D, Lizos DE, de Noronha RG, Longbottom DA. Total synthesis of halipeptins A and D and analogues. Angewandte Chemie (International Ed. in English). 44: 4925-9. PMID 16010700 DOI: 10.1002/anie.200500702  1
2005 Nicolaou KC, Bulger PG, Sarlah D. Metathesis reactions in total synthesis. Angewandte Chemie (International Ed. in English). 44: 4490-527. PMID 16003791 DOI: 10.1002/anie.200500369  1
2005 Nicolaou KC, Bulger PG, Sarlah D. Palladium-catalyzed cross-coupling reactions in total synthesis. Angewandte Chemie (International Ed. in English). 44: 4442-89. PMID 15991198 DOI: 10.1002/anie.200500368  1
2005 Nicolaou KC, Montagnon T, Vassilikogiannakis G, Mathison CJN. The total synthesis of coleophomones B, C, and D Journal of the American Chemical Society. 127: 8872-8888. PMID 15954796 DOI: 10.1021/ja0509984  1
2005 Nicolaou KC, Tang W, Dagneau P, Faraoni R. A catalytic asymmetric three-component 1,4-addition/aldol reaction: enantioselective synthesis of the spirocyclic system of vannusal A. Angewandte Chemie (International Ed. in English). 44: 3874-9. PMID 15900527 DOI: 10.1002/anie.200500789  1
2005 Nicolaou KC, Sang HL, Estrada AA, Zak M. Construction of substituted N-hydroxyindoles: Synthesis of a nocathiacin I model system Angewandte Chemie - International Edition. 44: 3736-3740. PMID 15892095 DOI: 10.1002/anie.200500724  1
2005 Nicolaou KC, Carenzi GEA, Jeso V. Construction of highly functionalized medium-sized rings: Synthesis of hyperforin and perforatumone model systems Angewandte Chemie - International Edition. 44: 3895-3899. PMID 15892032 DOI: 10.1002/anie.200500776  1
2005 Nicolaou KC, Sasmal PK, Koftis TV, Converso A, Loizidou E, Kaiser F, Roecker AJ, Dellios CC, Sun XW, Petrovic G. Studies toward the synthesis of azadirachtin, part 2: construction of fully functionalized ABCD ring frameworks and unusual intramolecular reactions induced by close-proximity effects. Angewandte Chemie (International Ed. in English). 44: 3447-52. PMID 15849805 DOI: 10.1002/anie.200500217  1
2005 Nicolaou KC, Sasmal PK, Roecker AJ, Sun XW, Mandal S, Converso A. Studies toward the synthesis of azadirachtin, part 1: total synthesis of a fully functionalized ABC ring framework and coupling with a norbornene domain. Angewandte Chemie (International Ed. in English). 44: 3443-7. PMID 15846829 DOI: 10.1002/anie.200500216  1
2005 Tan C, de Noronha RG, Roecker AJ, Pyrzynska B, Khwaja F, Zhang Z, Zhang H, Teng Q, Nicholson AC, Giannakakou P, Zhou W, Olson JJ, Pereira MM, Nicolaou KC, Van Meir EG. Identification of a novel small-molecule inhibitor of the hypoxia-inducible factor 1 pathway. Cancer Research. 65: 605-12. PMID 15695405  1
2005 Nicolaou KC, Snyder SA. Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation. Angewandte Chemie (International Ed. in English). 44: 1012-44. PMID 15688428 DOI: 10.1002/anie.200460864  1
2005 Nicolaou KC, Estrada AA, Zak M, Lee SH, Safina BS. A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide Angewandte Chemie - International Edition. 44: 1378-1382. PMID 15674985 DOI: 10.1002/anie.200462207  1
2005 Nicolaou KC, Xu H, Wartmann M. Biomimetic total synthesis of gambogin and rate acceleration of pericyclic reactions in aqueous media. Angewandte Chemie (International Ed. in English). 44: 756-61. PMID 15657969 DOI: 10.1002/anie.200462211  1
2004 Nicolaou KC, Snyder SA, Longbottom DA, Nalbandian AZ, Huang X. New uses for the Burgess reagent in chemical synthesis: methods for the facile and stereoselective formation of sulfamidates, glycosylamines, and sulfamides. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 5581-606. PMID 15470695 DOI: 10.1002/chem.200400503  1
2004 Nicolaou KC, Hao J, Reddy MV, Rao PB, Rassias G, Snyder SA, Huang X, Chen DY, Brenzovich WE, Giuseppone N, O'Brate A, Giannakakou P. Chemistry and biology of diazonamide A: second total synthesis and biological investigations. Journal of the American Chemical Society. 126: 12897-906. PMID 15469287 DOI: 10.1021/ja040093a  1
2004 Nicolaou KC, Chen DY, Huang X, Ling T, Bella M, Snyder SA. Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure. Journal of the American Chemical Society. 126: 12888-96. PMID 15469286 DOI: 10.1021/ja040092i  1
2004 Nicolaou KC, Safina BS, Zak M, Estrada AA, Lee SH. Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angewandte Chemie (International Ed. in English). 43: 5087-92. PMID 15372631 DOI: 10.1002/anie.200461340  1
2004 Nicolaou KC, Zak M, Safina BS, Lee SH, Estrada AA. Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angewandte Chemie (International Ed. in English). 43: 5092-7. PMID 15372630 DOI: 10.1002/anie.200461341  1
2004 Nicolaou KC, Vyskocil S, Koftis TV, Yamada YM, Ling T, Chen DY, Tang W, Petrovic G, Frederick MO, Li Y, Satake M. Structural revision and total synthesis of azaspiracid-1, part 1: intelligence gathering and tentative proposal. Angewandte Chemie (International Ed. in English). 43: 4312-8. PMID 15368380 DOI: 10.1002/anie.200460695  1
2004 Nicolaou KC, Snyder SA, Giuseppone N, Huang X, Bella M, Reddy MV, Rao PB, Koumbis AE, O'Brate A, Giannakakou P. Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure. Journal of the American Chemical Society. 126: 10174-82. PMID 15303893 DOI: 10.1021/ja040091q  1
2004 Nicolaou KC, Snyder SA, Huang X, Simonsen KB, Koumbis AE, Bigot A. Studies toward diazonamide A: initial synthetic forays directed toward the originally proposed structure. Journal of the American Chemical Society. 126: 10162-73. PMID 15303892 DOI: 10.1021/ja040090y  1
2004 Nicolaou KC, Snyder SA. The essence of total synthesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 11929-36. PMID 15302925 DOI: 10.1073/pnas.0403799101  1
2004 Nicolaou KC, Snyder SA, Nalbandian AZ, Longbottom DA. A new method for the stereoselective synthesis of alpha- and beta-glycosylamines using the Burgess reagent. Journal of the American Chemical Society. 126: 6234-5. PMID 15149212 DOI: 10.1021/ja049293c  1
2004 Buey RM, Díaz JF, Andreu JM, O'Brate A, Giannakakou P, Nicolaou KC, Sasmal PK, Ritzén A, Namoto K. Interaction of epothilone analogs with the paclitaxel binding site: relationship between binding affinity, microtubule stabilization, and cytotoxicity. Chemistry & Biology. 11: 225-36. PMID 15123284 DOI: 10.1016/j.chembiol.2004.01.014  1
2004 Nicolaou KC, Sasmal PK, Xu H. Biomimetically inspired total synthesis and structure activity relationships of 1-O-methyllateriflorone. 6 pi electrocyclizations in organic synthesis. Journal of the American Chemical Society. 126: 5493-501. PMID 15113221 DOI: 10.1021/ja040037+  1
2004 Nicolaou KC, Gray DL, Tae J. Total synthesis of hamigerans and analogues thereof. Photochemical generation and Diels-Alder trapping of hydroxy-o-quinodimethanes. Journal of the American Chemical Society. 126: 613-27. PMID 14719961 DOI: 10.1021/ja030498f  0.68
2004 Nicolaou KC, Gray DL. Total synthesis of hybocarpone and analogues thereof. A facile dimerization of naphthazarins to pentacyclic systems. Journal of the American Chemical Society. 126: 607-12. PMID 14719960 DOI: 10.1021/ja030497n  1
2003 Nicolaou KC, Kim DW, Baati R, O'Brate A, Giannakakou P. Total synthesis and biological evaluation of (-)apicularen A and analogues thereof. Chemistry (Weinheim An Der Bergstrasse, Germany). 9: 6177-91. PMID 14679529 DOI: 10.1002/chem.200305230  1
2003 Nicolaou KC, Li Y, Sugita K, Monenschein H, Guntupalli P, Mitchell HJ, Fylaktakidou KC, Vourloumis D, Giannakakou P, O'Brate A. Total synthesis of apoptolidin: completion of the synthesis and analogue synthesis and evaluation. Journal of the American Chemical Society. 125: 15443-54. PMID 14664590 DOI: 10.1021/ja030496v  1
2003 Nicolaou KC, Fylaktakidou KC, Monenschein H, Li Y, Weyershausen B, Mitchell HJ, Wei HX, Guntupalli P, Hepworth D, Sugita K. Total synthesis of apoptolidin: construction of enantiomerically pure fragments. Journal of the American Chemical Society. 125: 15433-42. PMID 14664589 DOI: 10.1021/ja0304953  1
2003 Nicolaou KC, Sasmal PK, Xu H, Namoto K, Ritzén A. Total synthesis of 1-O-methyllateriflorone. Angewandte Chemie (International Ed. in English). 42: 4225-9. PMID 14502742 DOI: 10.1002/anie.200351805  1
2003 Nicolaou KC, Evans RM, Roecker AJ, Hughes R, Downes M, Pfefferkorn JA. Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Organic & Biomolecular Chemistry. 1: 908-20. PMID 12929628 DOI: 10.1039/b300525a  1
2003 Nicolaou KC, Chen DY, Li Y, Qian W, Ling T, Vyskocil S, Koftis TV, Govindasamy M, Uesaka N. Total synthesis of the proposed azaspiracid-1 structure, part 2: coupling of the C1-C20, C21-C27, and C28-C40 fragments and completion of the synthesis. Angewandte Chemie (International Ed. in English). 42: 3649-53. PMID 12916037 DOI: 10.1002/anie.200351826  1
2003 Nicolaou KC, Li Y, Uesaka N, Koftis TV, Vyskocil S, Ling T, Govindasamy M, Qian W, Bernal F, Chen DY. Total synthesis of the proposed azaspiracid-1 structure, part 1: construction of the enantiomerically pure C1-C20, C21-C27, and C28-C40 fragments. Angewandte Chemie (International Ed. in English). 42: 3643-8. PMID 12916036 DOI: 10.1002/anie.200351825  1
2003 Nicolaou KC, Roecker AJ, Monenschein H, Guntupalli P, Follmann M. Studies towards the synthesis of azadirachtin: enantioselective entry into the azadirachtin framework through cascade reactions. Angewandte Chemie (International Ed. in English). 42: 3637-42. PMID 12916035 DOI: 10.1002/anie.200351744  1
2003 Nicolaou KC, Nevalainen M, Zak M, Bulat S, Bella M, Safina BS. Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angewandte Chemie (International Ed. in English). 42: 3418-24. PMID 12888975 DOI: 10.1002/anie.200351745  1
2003 Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular Cell. 11: 1079-92. PMID 12718892 DOI: 10.1016/S1097-2765(03)00104-7  1
2003 Nicolaou KC, Bheema Rao P, Hao J, Reddy MV, Rassias G, Huang X, Chen DY, Snyder SA. The second total synthesis of diazonamide A. Angewandte Chemie (International Ed. in English). 42: 1753-8. PMID 12707898 DOI: 10.1002/anie.200351112  1
2003 Nicolaou KC, Montagnon T, Snyder SA. Tandem reactions, cascade sequences, and biomimetic strategies in total synthesis. Chemical Communications (Cambridge, England). 551-64. PMID 12669826  1
2003 Nicolaou KC, Roecker AJ, Hughes R, van Summeren R, Pfefferkorn JA, Winssinger N. Novel strategies for the solid phase synthesis of substituted indolines and indoles. Bioorganic & Medicinal Chemistry. 11: 465-76. PMID 12517442 DOI: 10.1016/S0968-0896(02)00386-3  1
2002 Nicolaou KC, Montagnon T, Baran PS. HIO3 and I2O5: mild and selective alternative reagents to IBX for the dehydrogenation of aldehydes and ketones. Angewandte Chemie (International Ed. in English). 41: 1386-9. PMID 19750773 DOI: 10.1002/1521-3773(20020415)41:8<1386::AID-ANIE1386>3.0.CO;2-V  1
2002 Nicolaou KC, Snyder SA, Montagnon T, Vassilikogiannakis G. The Diels--Alder reaction in total synthesis. Angewandte Chemie (International Ed. in English). 41: 1668-98. PMID 19750686 DOI: 10.1002/1521-3773(20020517)41:10<1668::AID-ANIE1668>3.0.CO;2-Z  1
2002 Nicolaou KC, Nevalainen M, Safina BS, Zak M, Bulat S. A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton. Angewandte Chemie (International Ed. in English). 41: 1941-5. PMID 19750640 DOI: 10.1002/1521-3773(20020603)41:11<1941::AID-ANIE1941>3.0.CO;2-V  1
2002 Nicolaou KC, Safina BS, Funke C, Zak M, Zécri FJ. Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton. Angewandte Chemie (International Ed. in English). 41: 1937-40. PMID 19750639 DOI: 10.1002/1521-3773(20020603)41:11<1937::AID-ANIE1937>3.0.CO;2-Y  1
2002 Nicolaou KC, Roecker AJ, Follmann M, Baati R. Model studies towards azadirachtin: part 2. Construction of the crowded C8-C14 bond by transition metal chemistry. Angewandte Chemie (International Ed. in English). 41: 2107-10. PMID 19746611 DOI: 10.1002/1521-3773(20020617)41:12<2107::AID-ANIE2107>3.0.CO;2-4  1
2002 Nicolaou KC, Follmann M, Roecker AJ, Hunt KW. Model studies towards azadirachtin: part 1. Construction of the crowded C8-C14 bond by radical chemistry. Angewandte Chemie (International Ed. in English). 41: 2103-6. PMID 19746610 DOI: 10.1002/1521-3773(20020617)41:12<2103::AID-ANIE2103>3.0.CO;2-S  1
2002 Nicolaou KC, Huang X, Snyder SA, Bheema Rao P, Bella M, Reddy MV. A novel regio- and stereoselective synthesis of sulfamidates from 1,2-diols using Burgess and related reagents: a facile entry into beta-amino alcohols. Angewandte Chemie (International Ed. in English). 41: 834-8. PMID 12491352 DOI: 10.1002/1521-3773(20020301)41:5<834::AID-ANIE834>3.0.CO;2-V  1
2002 Nicolaou KC, Gray DL, Montagnon T, Harrison ST. Oxidation of silyl enol ethers by using IBX and IBX.N-oxide complexes: a mild and selective reaction for the synthesis of enones. Angewandte Chemie (International Ed. in English). 41: 996-1000. PMID 12491292 DOI: 10.1002/1521-3773(20020315)41:6<996::AID-ANIE996>3.0.CO;2-I  1
2002 Nicolaou KC, Montagnon T, Baran PS. Modulation of the reactivity profile of IBX by ligand complexation: ambient temperature dehydrogenation of aldehydes and ketones to alpha,beta-unsaturated carbonyl compounds. Angewandte Chemie (International Ed. in English). 41: 993-6. PMID 12491291 DOI: 10.1002/1521-3773(20020315)41:6<993::AID-ANIE993>3.0.CO;2-U  1
2002 Nicolaou KC, Longbottom DA, Snyder SA, Nalbanadian AZ, Huang X. A new method for the synthesis of nonsymmetrical sulfamides using burgess-type reagents. Angewandte Chemie (International Ed. in English). 41: 3866-70. PMID 12386873 DOI: 10.1002/1521-3773(20021018)41:20<3866::AID-ANIE3866>3.0.CO;2-T  1
2002 Nicolaou KC, Kim DW, Baati R. Stereocontrolled total synthesis of apicularen A and its delta(17,18) Z isomer. Angewandte Chemie (International Ed. in English). 41: 3701-4; 3523. PMID 12370936 DOI: 10.1002/1521-3773(20021004)41:19<3701::AID-ANIE3701>3.0.CO;2-4  1
2002 Nicolaou KC, Bella M, Chen DY, Huang X, Ling T, Snyder SA. Total synthesis of diazonamide A. Angewandte Chemie (International Ed. in English). 41: 3495-9. PMID 12298077 DOI: 10.1002/1521-3773(20020916)41:18<3495::AID-ANIE3495>3.0.CO;2-7  1
2002 Wrasidlo W, Gaedicke G, Guy RK, Renaud J, Pitsinos E, Nicolaou KC, Reisfeld RA, Lode HN. A novel 2'-(N-methylpyridinium acetate) prodrug of paclitaxel induces superior antitumor responses in preclinical cancer models. Bioconjugate Chemistry. 13: 1093-9. PMID 12236791 DOI: 10.1021/bc0200226  0.48
2002 Nicolaou KC, Baran PS. The CP molecule labyrinth: a paradigm of how endeavors in total synthesis lead to discoveries and inventions in organic synthesis. Angewandte Chemie (International Ed. in English). 41: 2678-720. PMID 12203464 DOI: 10.1002/1521-3773(20020802)41:15<2678::AID-ANIE2678>3.0.CO;2-V  1
2002 Nicolaou KC, Boddy CN. Atropselective macrocyclization of diaryl ether ring systems: application to the synthesis of vancomycin model systems. Journal of the American Chemical Society. 124: 10451-5. PMID 12197747 DOI: 10.1021/ja020736r  1
2002 Nicholas GM, Eckman LL, Ray S, Hughes RO, Pfefferkorn JA, Barluenga S, Nicolaou KC, Bewley CA. Bromotyrosine-derived natural and synthetic products as inhibitors of mycothiol-S-conjugate amidase. Bioorganic & Medicinal Chemistry Letters. 12: 2487-90. PMID 12161164 DOI: 10.1016/S0960-894X(02)00385-2  1
2002 Nicolaou KC, Montagnon T, Ulven T, Baran PS, Zhong YL, Sarabia F. Novel chemistry of alpha-tosyloxy ketones: applications to the solution- and solid-phase synthesis of privileged heterocycle and enediyne libraries. Journal of the American Chemical Society. 124: 5718-28. PMID 12010045 DOI: 10.1021/ja012146j  1
2002 Nicolaou KC, Montagnon T, Baran PS, Zhong YL. Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes. Journal of the American Chemical Society. 124: 2245-58. PMID 11878978 DOI: 10.1021/ja012127+  1
2002 Nicolaou KC, Baran PS, Zhong YL, Barluenga S, Hunt KW, Kranich R, Vega JA. Iodine(V) reagents in organic synthesis. Part 3. New routes to heterocyclic compounds via o-iodoxybenzoic acid-mediated cyclizations: generality, scope, and mechanism. Journal of the American Chemical Society. 124: 2233-44. PMID 11878977 DOI: 10.1021/ja012126h  1
2002 Nicolaou KC, Sugita K, Baran PS, Zhong YL. Iodine(V) reagents in organic synthesis. Part 2. Access to complex molecular architectures via Dess-Martin periodinane-generated o-imidoquinones. Journal of the American Chemical Society. 124: 2221-32. PMID 11878976 DOI: 10.1021/ja012125p  1
2002 Nicolaou KC, Baran PS, Zhong YL, Sugita K. Iodine(V) reagents in organic synthesis. Part 1. Synthesis of polycyclic heterocycles via Dess-Martin periodinane-mediated cascade cyclization: generality, scope, and mechanism of the reaction. Journal of the American Chemical Society. 124: 2212-20. PMID 11878975 DOI: 10.1021/ja012124x  1
2002 Nicolaou KC, Zhong YL, Baran PS, Jung J, Choi HS, Yoon WH. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 3. Completion and synthesis of advanced analogues. Journal of the American Chemical Society. 124: 2202-11. PMID 11878974 DOI: 10.1021/ja0120126  1
2002 Nicolaou KC, Baran PS, Zhong YL, Fong KC, Choi HS. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 2. Model studies for the construction of key structural elements and first-generation strategy. Journal of the American Chemical Society. 124: 2190-201. PMID 11878973 DOI: 10.1021/ja012011d  1
2002 Nicolaou KC, Jung J, Yoon WH, Fong KC, Choi HS, He Y, Zhong YL, Baran PS. Total synthesis of the CP-molecules (CP-263,114 and CP-225,917, phomoidrides B and A). 1. Racemic and asymmetric synthesis of bicyclo[4.3.1] key building blocks. Journal of the American Chemical Society. 124: 2183-9. PMID 11878972 DOI: 10.1021/ja012010l  1
2001 Nicolaou KC, Qian W, Bernal F, Uesaka N, Pihko PM, Hinrichs J. Synthesis of the ABCD Ring System of Azaspiracid We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a predoctoral fellowship from Bristol-Myers Squibb (to F.B.), postdoctoral fellowships from The Skaggs Institute for Research (to W.Q.), the Academy of Finland, the Ella and Georg Ehrnrooth Foundation and the Tauno Tönning Foundation (all to P.M.P.), and Bayer AG (to J.H.), as well as grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 4068-4071. PMID 12404495 DOI: 10.1002/1521-3773(20011105)40:21<4068::AID-ANIE4068>3.0.CO;2-Y  1
2001 Nicolaou KC, Huang X, Giuseppone N, Bheema Rao P, Bella M, Reddy MV, Snyder SA. Construction of the Complete Aromatic Core of Diazonamide A by a Novel Hetero Pinacol Macrocyclization Cascade Reaction We thank Drs. D. H. Huang and G. Suizdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), American Biosciences, a predoctoral fellowship from the National Science Foundation (S.A.S.), a postdoctoral fellowship from the Association pour la Recherche sur le Cancer (N.G.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 4705-4709. PMID 12404390 DOI: 10.1002/1521-3773(20011217)40:24<4705::AID-ANIE4705>3.0.CO;2-D  1
2001 Nicolaou KC, Ritzén A, Namoto K. Recent developments in the chemistry, biology and medicine of the epothilones. Chemical Communications (Cambridge, England). 1523-35. PMID 12240368  1
2001 Nicolaou KC, Roecker AJ, Barluenga S, Pfefferkorn JA, Cao GQ. Discovery of novel antibacterial agents active against methicillin-resistant Staphylococcus aureus from combinatorial benzopyran libraries. Chembiochem : a European Journal of Chemical Biology. 2: 460-5. PMID 11828478 DOI: 10.1002/1439-7633(20010601)2:6<460::AID-CBIC460>3.0.CO;2-2  1
2001 Nicolaou KC, Namoto K, Li J, Ritzén A, Ulven T, Shoji M, Zaharevitz D, Gussio R, Sackett DL, Ward RD, Hensler A, Fojo T, Giannakakou P. Synthesis and biological evaluation of 12,13-cyclopropyl and 12,13-cyclobutyl epothilones. Chembiochem : a European Journal of Chemical Biology. 2: 69-75. PMID 11828429 DOI: 10.1002/1439-7633(20010105)2:1<69::AID-CBIC69>3.0.CO;2-8  1
2001 Nicolaou KC, Pfefferkorn JA. Solid phase synthesis of complex natural products and libraries thereof. Biopolymers. 60: 171-93. PMID 11774224 DOI: 10.1002/1097-0282(2001)60:3<171::AID-BIP10030>3.0.CO;2-M  1
2001 Nicolaou KC, Hughes R, Pfefferkorn JA, Barluenga S. Optimization and mechanistic studies of psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 4296-310. PMID 11686610 DOI: 10.1002/1521-3765(20011001)7:19<4296::AID-CHEM4296>3.0.CO;2-2  1
2001 Nicolaou KC, Hughes R, Pfefferkorn JA, Barluenga S, Roecker AJ. Combinatorial synthesis through disulfide exchange: discovery of potent psammaplin A type antibacterial agents active against methicillin-resistant Staphylococcus aureus (MRSA). Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 4280-95. PMID 11686609 DOI: 10.1002/1521-3765(20011001)7:19<4280::AID-CHEM4280>3.0.CO;2-3  1
2001 Nicolaou KC, Li Y, Fylaktakidou KC, Mitchell HJ, Sugita K. Total Synthesis of Apoptolidin: Part 2. Coupling of Key Building Blocks and Completion of the Synthesis We thank Dr. C. Khosla and Dr. Y. Hayakawa for generous gifts of apoptolidin, and Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a predoctoral fellowship from Boehringer Ingelheim (to Y.L.), a postdoctoral fellowship the George Hewitt Foundation (to K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 3854-3857. PMID 11668554 DOI: 10.1002/1521-3773(20011015)40:20<3854::AID-ANIE3854>3.0.CO;2-D  1
2001 Nicolaou KC, Li Y, Fylaktakidou KC, Mitchell HJ, Wei HX, Weyershausen B. Total Synthesis of Apoptolidin: Part 1. Retrosynthetic Analysis and Construction of Building Blocks We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), the Skaggs Institute for Chemical Biology, American Biosciences, a pre-doctoral fellowship from Boehringer Ingelheim (Y.L.), a postdoctoral fellowship the George Hewitt Foundation (K.C.F.), and grants from Abbott Laboratories, ArrayBiopharma, Bayer, Boehringer Ingelheim, DuPont, Glaxo, Hoffmann-LaRoche, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 3849-3854. PMID 11668553 DOI: 10.1002/1521-3773(20011015)40:20<3849::AID-ANIE3849>3.0.CO;2-M  1
2001 Nicolaou KC, Hughes R, Cho SY, Winssinger N, Labischinski H, Endermann R. Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 3824-43. PMID 11575783 DOI: 10.1002/1521-3765(20010903)7:17<3824::AID-CHEM3824>3.0.CO;2-1  1
2001 Nicolaou KC, Cho SY, Hughes R, Winssinger N, Smethurst C, Labischinski H, Endermann R. Solid- and solution-phase synthesis of vancomycin and vancomycin analogues with activity against vancomycin-resistant bacteria. Chemistry (Weinheim An Der Bergstrasse, Germany). 7: 3798-823. PMID 11575782 DOI: 10.1002/1521-3765(20010903)7:17<3798::AID-CHEM3798>3.0.CO;2-6  1
2001 Nicolaou KC, Namoto K, Ritzén A, Ulven T, Shoji M, Li J, D'Amico G, Liotta D, French CT, Wartmann M, Altmann KH, Giannakakou P. Chemical synthesis and biological evaluation of cis- and trans-12,13-cyclopropyl and 12,13-cyclobutyl epothilones and related pyridine side chain analogues. Journal of the American Chemical Society. 123: 9313-23. PMID 11562214 DOI: 10.1021/ja011338b  1
2001 Nicolaou KC, Baran PS, Zhong YL. Selective oxidation at carbon adjacent to aromatic systems with IBX. Journal of the American Chemical Society. 123: 3183-5. PMID 11457049 DOI: 10.1021/ja004218x  1
2001 Nicolaou KC, Zhong YL, Baran PS, Sugita K. Rapid Access to Complex Molecular Architectures via o-Azaquinones We thank Dr. D. H. Huang, G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. This work was supported financially by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.S.B), and grants from ArrayBiopharma, Pfizer, Glaxo, Merck, Schering Plough, Hoffmann-La Roche, Boehringer Ingelheim, DuPont, and Abbott Laboratories. Angewandte Chemie (International Ed. in English). 40: 2145-2149. PMID 11433472 DOI: 10.1002/1521-3773(20010601)40:11<2145::AID-ANIE2145>3.0.CO;2-M  1
2001 Nicolaou KC, Mitchell HJ. Adventures in Carbohydrate Chemistry: New Synthetic Technologies, Chemical Synthesis, Molecular Design, and Chemical Biology A list of abbreviations can be found at the end of this article. Telemachos Charalambous was an inspiring teacher at the Pancyprian Gymnasium, Nicosia, Cyprus. Angewandte Chemie (International Ed. in English). 40: 1576-1624. PMID 11353467 DOI: 10.1002/1521-3773(20010504)40:9<1576::AID-ANIE15760>3.0.CO;2-G  1
2001 Nicolaou KC, Pihko PM, Diedrichs N, Zou N, Bernal F. Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 1573. PMID 11353466 DOI: 10.1002/1521-3773(20010504)40:9<1573::AID-ANIE15733>3.0.CO;2-D  0.92
2001 Nicolaou KC, Sugita K, Baran PS, Zhong YL. New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 1573. PMID 11353465 DOI: 10.1002/1521-3773(20010504)40:9<1573::AID-ANIE15732>3.0.CO;2-G  1
2001 Nicolaou KC, Boddy CN. Behind enemy lines. Scientific American. 284: 54-61. PMID 11341163  1
2001 Nicolaou KC, Pihko PM, Diedrichs N, Zou N, Bernal F. Synthesis of the FGHI Ring System of Azaspiracid We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from Bristol-Myers Squibb (F.B.), postdoctoral fellowships from the Academy of Finland, the Ella and Georg Ehrnrooth Foundation, and the Tauno Tönning Foundation (all to P.M.P.), ArrayBiopharma (N.Z.), and Bayer AG (N.D.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 1262-1265. PMID 11301444 DOI: 10.1002/1521-3773(20010401)40:7<1262::AID-ANIE1262>3.0.CO;2-9  1
2001 Nicolaou KC, Boddy CN, Siegel JS. Does CIP Nomenclature Adequately Handle Molecules with Multiple Stereoelements? A Case Study of Vancomycin and Cognates We would like to thank Professor Dieter Hellwinkel for pointing out to us the stereochemical discrepancies in our review6 and elsewhere in the literature, and Kurt Mislow for stimulating and useful discussions. Angewandte Chemie (International Ed. in English). 40: 701-704. PMID 11241596 DOI: 10.1002/1521-3773(20010216)40:4<701::AID-ANIE7010>3.0.CO;2-O  1
2001 Nicolaou KC, Sugita K, Baran PS, Zhong YL. New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 207-210. PMID 11169714 DOI: 10.1002/1521-3773(20010105)40:1<207::AID-ANIE207>3.0.CO;2-K  1
2001 Nicolaou KC, Baran PS, Kranich R, Zhong YL, Sugita K, Zou N. Mechanistic Studies of Periodinane-Mediated Reactions of Anilides and Related Systems Professors M. G. Finn, A. Eschenmoser, and M. E. Newcomb are gratefully acknowledged for valuable discussions and suggestions. We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. We would also like to thank Dr. G. Vasilikogiannakis for helpful discussions and an anonymous referee for critical suggestions. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), postdoctoral fellowships from ArrayBiopharma (N.Z.) and Bayer AG (R.K.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 40: 202-206. PMID 11169713 DOI: 10.1002/1521-3773(20010105)40:1<202::AID-ANIE202>3.0.CO;2-3  0.48
2000 Nicolaou KC, Snyder SA, Simonsen KB, Koumbis AE. Model Studies towards Diazonamide A: Synthesis of the Heterocyclic Core We thank Dr. D. H. Huang, Dr. G. Suizdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. We also thank Professor R. H. Grubbs for a generous gift of catalyst 30. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (S.A.S.), postdoctoral fellowships from the Alfred Benzons Foundation and the Danish Natural Science Research Council (K.B.S.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, GlaxoWellcome, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 39: 3473-3478. PMID 11091394 DOI: 10.1002/1521-3773(20001002)39:19<3473::AID-ANIE3473>3.0.CO;2-E  1
2000 Nicolaou KC, Fylaktakidou KC, Mitchell HJ, van Delft FL, Rodríguez RM, Conley SR, Jin Z. Total synthesis of everninomicin 13,384-1--Part 4: explorations of methodology; stereocontrolled synthesis of 1,1'-disaccharides, 1,2-seleno migrations in carbohydrates, and solution- and solid-phase synthesis of 2-deoxy glycosides and orthoesters. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3166-85. PMID 11002995 DOI: 10.1002/1521-3765(20000901)6:17<3166::AID-CHEM3166>3.0.CO;2-Z  1
2000 Nicolaou KC, Mitchell HJ, Rodríguez RM, Fylaktakidou KC, Suzuki H, Conley SR. Total synthesis of everninomicin 13,384-1--Part 3: synthesis of the DE fragment and completion of the total synthesis. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3149-65. PMID 11002994 DOI: 10.1002/1521-3765(20000901)6:17<3149::AID-CHEM3149>3.0.CO;2-L  1
2000 Nicolaou KC, Mitchell HJ, Fylaktakidou KC, Rodríguez RM, Suzuki H. Total synthesis of everninomicin 13,384-1--Part 2: synthesis of the FGHA2 fragment. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3116-48. PMID 11002993 DOI: 10.1002/1521-3765(20000901)6:17<3116::AID-CHEM3116>3.0.CO;2-8  1
2000 Nicolaou KC, Rodríguez RM, Mitchell HJ, Suzuki H, Fylaktakidou KC, Baudoin O, van Delft FL. Total synthesis of everninomicin 13,384-1--Part 1: retrosynthetic analysis and synthesis of the A1B(A)C fragment. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 3095-115. PMID 11002992 DOI: 10.1002/1521-3765(20000901)6:17<3095::AID-CHEM3095>3.0.CO;2-4  1
2000 Nicolaou KC, Hepworth D, King NP, Finlay MR, Scarpelli R, Pereira MM, Bollbuck B, Bigot A, Werschkun B, Winssinger N. Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 2783-800. PMID 10985727 DOI: 10.1002/1521-3765(20000804)6:15<2783::AID-CHEM2783>3.0.CO;2-B  1
2000 Nicolaou KC, Koumbis AE, Snyder SA, Simonsen KB. Novel Reactions Initiated by Titanocene Methylidenes: Deoxygenation of Sulfoxides, N-Oxides, and Selenoxides We thank Drs. D. H. Huang and G. Suizdak for NMR spectroscopic and mass spectroscopic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from the National Science Foundation (S.A.S.) and the Alfred Benzons Foundation (K.B.S.), and grants from Abbott, Amgen, Boehringer-Ingelheim, GlaxoWellcome, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 39: 2529-2533. PMID 10941126 DOI: 10.1002/1521-3773(20000717)39:14<2529::AID-ANIE2529>3.0.CO;2-E  1
2000 Nicolaou KC, Baran PS, Zhong YL, Vega JA. Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively, and Prof. H. M. R. Hoffmann and Prof. A. Eschenmoser for helpful discussions. We also thank Dr. Maria-Rosa Rodriguez and Mr. Keith Wilcoxen of these laboratories for early intermediates leading to 9-12. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, fellowships from the Ministerio de Educacion y Cultura, Spain (J.A.V.) and the National Science Foundation (P.S.B), and grants from Array Biopharma, Pfizer, GlaxoWellcome, Merck, Schering Plough, Hoffmann-LaRoche, Boehringer Ingelheim, DuPont, and Abbott Laboratories. Angewandte Chemie (International Ed. in English). 39: 2525-2529. PMID 10941125 DOI: 10.1002/1521-3773(20000717)39:14<2525::AID-ANIE2525>3.0.CO;2-1  1
2000 Nicolaou KC, Jung JK, Yoon WH, He Y, Zhong YL, Baran PS. The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A) We thank Drs. D. H. Huang, G. Siuzdak, and R. Chadha for assistance with NMR spectroscopy, mass spectrometry, and X-ray crystallography, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, doctoral fellowships from the National Science Foundation (P.S.B.) and Boehringer Ingelheim (Y.H.), and grants from Array Biopharma, Boehringer Ingelheim, Schering Plough, Pfizer, Glaxo, Merck, Hoffmann-La Roche, DuPont, and Abbott Laboratories. Angewandte Chemie (International Ed. in English). 39: 1829-1832. PMID 10934377 DOI: 10.1002/(SICI)1521-3773(20000515)39:10<1829::AID-ANIE1829>3.0.CO;2-6  1
2000 Nicolaou KC, Vassilikogiannakis G, Kranich R, Baran PS, Zhong YL, Natarajan S. New Synthetic Technology for the Mild and Selective One-Carbon Homologation of Hindered Aldehydes in the Presence of Ketones. Organic Letters. 2: 1895-1898. PMID 10891185  1
2000 Nicolaou KC, Snyder SA, Bigot A, Pfefferkorn JA. Solution and Solid-Phase Synthesis of Functionalized 3-Arylbenzofurans by a Novel Cyclofragmentation - Release Pathway Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), doctoral fellowships from the National Science Foundation (S.A.S.) and the Department of Defense (J.A.P.), and grants from Abbott, Amgen, Boehringer - Ingelheim, Glaxo, Hoffmann - La Roche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie (International Ed. in English). 39: 1093-1096. PMID 10760931 DOI: 10.1002/(SICI)1521-3773(20000317)39:6<1093::AID-ANIE1093>3.0.CO;2-S  1
2000 Nicolaou KC, Mitchell HJ, Fylaktakidou KC, Suzuki H, Rodríguez RM. 1,2-Seleno Migrations in Carbohydrate Chemistry: Solution and Solid-Phase Synthesis of 2-Deoxy Glycosides, Orthoesters, and Allyl Orthoesters We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. We gratefully thank Nicolas Winssinger for helpful discussions and preparation of the selenium bromide resin. This work was financially supported by the Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), postdoctoral fellowships from M.E.C., Spain (R.M.R., Fullbright), the Japan Society for the Promotion of Science (H.S.), the George Hewitt Foundation (K.C.F.), and grants from Schering Plough, Pfizer, Glaxo, Merck, Hoffmann - La Roche, DuPont, Abbott Laboratories, and Boehringer - Ingelheim. Angewandte Chemie (International Ed. in English). 39: 1089-1093. PMID 10760930 DOI: 10.1002/(SICI)1521-3773(20000317)39:6<1089::AID-ANIE1089>3.0.CO;2-V  1
2000 Nicolaou KC, Winssinger N, Hughes R, Smethurst C, Cho SY. New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, a fellowship from the George Hewitt Foundation (N. W.), and grants from Schering Plough, Pfizer, Glaxo, Merck, Hoffmann-La Roche, DuPont, and Abbott Laboratories. Angewandte Chemie (International Ed. in English). 39: 1084-1088. PMID 10760929 DOI: 10.1002/(SICI)1521-3773(20000317)39:6<1084::AID-ANIE1084>3.0.CO;2-O  1
2000 Nicolaou KC, Cao GQ, Pfefferkorn JA. Selenium-Based Solid-Phase Synthesis of Benzopyrans II: Applications to Combinatorial Synthesis of Medicinally Relevant Small Organic Molecules. Angewandte Chemie (International Ed. in English). 39: 739-743. PMID 10760853 DOI: 10.1002/(SICI)1521-3773(20000218)39:4<739::AID-ANIE739>3.0.CO;2-Z  1
2000 Nicolaou KC, Pfefferkorn JA, Cao GQ. Selenium-Based Solid-Phase Synthesis of Benzopyrans I: Applications to Combinatorial Synthesis of Natural Products. Angewandte Chemie (International Ed. in English). 39: 734-739. PMID 10760852 DOI: 10.1002/(SICI)1521-3773(20000218)39:4<734::AID-ANIE734>3.0.CO;2-I  1
2000 Nicolaou KC, Zhong YL, Baran PS. New Synthetic Technology for the Rapid Construction of Novel Heterocycles-Part 2. The Reaction of IBX with Anilides and Related Compounds. Angewandte Chemie (International Ed. in English). 39: 625-628. PMID 10671279 DOI: 10.1002/(SICI)1521-3773(20000204)39:3<625::AID-ANIE625>3.0.CO;2-#  1
2000 Nicolaou KC, Zhong YL, Baran PS. New Synthetic Technology for the Rapid Construction of Novel Heterocycles-Part 1: The Reaction of Dess - Martin Periodinane with Anilides and Related Compounds. Angewandte Chemie (International Ed. in English). 39: 622-625. PMID 10671278 DOI: 10.1002/(SICI)1521-3773(20000204)39:3<622::AID-ANIE622>3.0.CO;2-B  1
2000 Nicolaou KC, Vourloumis D, Winssinger N, Baran PS. The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century. Angewandte Chemie (International Ed. in English). 39: 44-122. PMID 10649349 DOI: 10.1002/(SICI)1521-3773(20000103)39:1<44::AID-ANIE44>3.0.CO;2-L  1
1999 Nicolaou KC, Baran PS, Zhong YL, Choi HS, Fong KC, He Y, Yoon WH. New synthetic technology for the synthesis of hindered alpha-diazoketones via acyl mesylates. Organic Letters. 1: 883-6. PMID 10823217  1
1999 Nicolaou KC, Pfefferkorn JA, Cao GQ, Kim S, Kessabi J. A facile method for the solution and solid-phase synthesis of substituted [3.3.1] bicycles. Organic Letters. 1: 807-10. PMID 10823208  1
1999 Nicolaou KC, He Y, Fong KC, Yoon WH, Choi HS, Zhong YL, Baran PS. Novel strategies to construct the gamma-hydroxy lactone moiety of the CP molecules. Synthesis of the CP-225,917 core skeleton. Organic Letters. 1: 63-6. PMID 10822534  1
1999 Nicolaou KC, Simonsen KB, Vassilikogiannakis G, Baran PS, Vidali VP, Pitsinos EN, Couladouros EA. Biomimetic Explorations Towards the Bisorbicillinoids: Total Synthesis of Bisorbicillinol, Bisorbibutenolide, and Trichodimerol. Angewandte Chemie (International Ed. in English). 38: 3555-3559. PMID 10602241 DOI: 10.1002/(SICI)1521-3773(19991203)38:23<3555::AID-ANIE3555>3.0.CO;2-Z  1
1999 Nicolaou KC, Mitchell HJ, Rodríguez RM, Fylaktakidou KC, Suzuki H. Total Synthesis of Everninomicin 13,384-1-Part 3: Synthesis of the DE Fragment and Completion of the Total Synthesis. Angewandte Chemie (International Ed. in English). 38: 3345-3350. PMID 10602190 DOI: 10.1002/(SICI)1521-3773(19991115)38:22<3345::AID-ANIE3345>3.0.CO;2-9  1
1999 Nicolaou KC, Rodríguez RM, Fylaktakidou KC, Suzuki H, Mitchell HJ. Total Synthesis of Everninomicin 13,384-1-Part 2: Synthesis of the FGHA(2) Fragment. Angewandte Chemie (International Ed. in English). 38: 3340-3345. PMID 10602189 DOI: 10.1002/(SICI)1521-3773(19991115)38:22<3340::AID-ANIE3340>3.0.CO;2-2  1
1999 Nicolaou KC, Mitchell HJ, Suzuki H, Rodríguez RM, Baudoin O, Fylaktakidou KC. Total Synthesis of Everninomicin 13,384-1-Part 1: Synthesis of the A(1)B(A)C Fragment. Angewandte Chemie (International Ed. in English). 38: 3334-3339. PMID 10602188 DOI: 10.1002/(SICI)1521-3773(19991115)38:22<3334::AID-ANIE3334>3.0.CO;2-H  1
1999 Nicolaou KC, Pfefferkorn J, Xu J, Winssinger N, Ohshima T, Kim S, Hosokawa S, Vourloumis D, van Delft F, Li T. Total synthesis and chemical biology of the sarcodictyins. Chemical & Pharmaceutical Bulletin. 47: 1199-213. PMID 10517002  1
1999 Nicolaou KC, Xu J, Murphy F, Barluenga S, Baudoin O, Wei Hx, Gray DL, Ohshima T. Total Synthesis of Sanglifehrin A. Angewandte Chemie (International Ed. in English). 38: 2447-2451. PMID 10458817 DOI: 10.1002/(SICI)1521-3773(19990816)38:16<2447::AID-ANIE2447>3.0.CO;2-O  0.88
1999 Nicolaou KC, Boddy CN, Bräse S, Winssinger N. Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics. Angewandte Chemie (International Ed. in English). 38: 2096-2152. PMID 10425471 DOI: 10.1002/(SICI)1521-3773(19990802)38:15<2096::AID-ANIE2096>3.0.CO;2-F  1
1999 Setyawan J, Koide K, Diller TC, Bunnage ME, Taylor SS, Nicolaou KC, Brunton LL. Inhibition of protein kinases by balanol: specificity within the serine/threonine protein kinase subfamily. Molecular Pharmacology. 56: 370-6. PMID 10419556  1
1999 Nicolaou KC, King NP, Finlay MR, He Y, Roschangar F, Vourloumis D, Vallberg H, Sarabia F, Ninkovic S, Hepworth D. Total synthesis of epothilone E and related side-chain modified analogues via a Stille coupling based strategy. Bioorganic & Medicinal Chemistry. 7: 665-97. PMID 10400321 DOI: 10.1016/S0968-0896(98)00153-9  1
1999 Narayana N, Diller TC, Koide K, Bunnage ME, Nicolaou KC, Brunton LL, Xuong NH, Ten Eyck LF, Taylor SS. Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry. 38: 2367-76. PMID 10029530 DOI: 10.1021/bi9820659  1
1998 Nicolaou KC, Finlay MR, Ninkovic S, King NP, He Y, Li T, Sarabia F, Vourloumis D. Synthesis and biological properties of C12,13-cyclopropyl-epothilone A and related epothilones. Chemistry & Biology. 5: 365-72. PMID 9662505  1
1998 Nicolaou KC, Yang Z, Shi G, Gunzner JL, Agrios KA, Gärtner P. Total synthesis of brevetoxin A. Nature. 392: 264-9. PMID 9521320 DOI: 10.1038/32623  1
1997 Nicolaou KC, Winssinger N, Pastor J, Ninkovic S, Sarabia F, He Y, Vourloumis D, Yang Z, Li T, Giannakakou P, Hamel E. Synthesis of epothilones A and B in solid and solution phase. Nature. 387: 268-72. PMID 9153390 DOI: 10.1038/387268a0  1
1996 Nicolaou KC, Guy RK, Potier P. Taxoids: new weapons against cancer. Scientific American. 274: 94-8. PMID 8643952  0.48
1996 Liu C, Smith BM, Ajito K, Komatsu H, Gomez-Paloma L, Li T, Theodorakis EA, Nicolaou KC, Vogt PK. Sequence-selective carbohydrate-DNA interaction: dimeric and monomeric forms of the calicheamicin oligosaccharide interfere with transcription factor function. Proceedings of the National Academy of Sciences of the United States of America. 93: 940-4. PMID 8570664 DOI: 10.1073/pnas.93.2.940  1
1995 Koide K, Bunnage ME, Gomez Paloma L, Kanter JR, Taylor SS, Brunton LL, Nicolaou KC. Molecular design and biological activity of potent and selective protein kinase inhibitors related to balanol. Chemistry & Biology. 2: 601-8. PMID 9383464  0.56
1995 Gawley RE, Rein KS, Jeglitsch G, Adams DJ, Theodorakis EA, Tiebes J, Nicolaou KC, Baden DG. The relationship of brevetoxin 'length' and A-ring functionality to binding and activity in neuronal sodium channels. Chemistry & Biology. 2: 533-41. PMID 9383457 DOI: 10.1016/1074-5521(95)90187-6  1
1994 Gomez Paloma L, Guy RK, Wrasidlo W, Nicolaou KC. Conformation of a water-soluble derivative of taxol in water by 2D-NMR spectroscopy. Chemistry & Biology. 1: 107-12. PMID 9383378 DOI: 10.1016/1074-5521(94)90048-5  1
1994 Nicolaou KC, Pitsinos EN, Theodorakis EA, Saimoto H, Wrasidlo W. Synthetic calicheamicin mimics with novel initiation mechanisms: DNA cleavage, cytotoxicity, and apoptosis. Chemistry & Biology. 1: 57-66. PMID 9383371 DOI: 10.1016/1074-5521(94)90041-8  1
1994 Nicolaou KC, Yang Z, Liu JJ, Ueno H, Nantermet PG, Guy RK, Claiborne CF, Renaud J, Couladouros EA, Paulvannan K. Total synthesis of taxol. Nature. 367: 630-4. PMID 7906395 DOI: 10.1038/367630a0  1
1993 Nicolaou KC, Riemer C, Kerr MA, Rideout D, Wrasidlo W. Design, synthesis and biological activity of protaxols. Nature. 364: 464-6. PMID 8101355 DOI: 10.1038/364464a0  1
1985 Smith JB, Roth DM, Lefer AM, Petasis NA, Nicolaou KC. Modulation of leukotriene synthesis and actions by synthetic derivatives of arachidonic acid. Prostaglandins. 29: 765-71. PMID 4011927 DOI: 10.1016/0090-6980(85)90136-4  1
1982 Koshishara Y, Murota S, Petasis NA, Nicolaou KC. Selective inhibition of 5-lipoxygenase by 5,6-methanoleukotriene A4, a stable analogue of leukotriene A4. Febs Letters. 143: 13-6. PMID 6811315 DOI: 10.1016/0014-5793(82)80262-7  1
1976 Webber PC, Larsson C, Anggard E, Hamberg M, Corey EJ, Nicolaou KC, Samuelsson B. Stimulation of renin release from rabbit renal cortex by arachidonic acid and prostaglandin endoperoxides. Circulation Research. 39: 868-74. PMID 1000781  0.56
1975 Corey EJ, Nicolaou KC, Toru T. Letter: Total synthesis of (plus or minus)-vermiculine. Journal of the American Chemical Society. 97: 2287-8. PMID 1133413  0.56
1975 Corey EJ, Nicolaou KC, Machida Y, Malmsten CL, Samuelsson B. Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proceedings of the National Academy of Sciences of the United States of America. 72: 3355-8. PMID 1059121  0.56
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