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Enfu Hui, Ph.D. - Publications

Affiliations: 
2010-2016 Cellular and Molecular Pharmacology University of California, San Francisco, San Francisco, CA 
 2016- Cell and Developmental Biology University of California, San Diego, La Jolla, CA 
Area:
T cell signaling
Website:
https://biology.ucsd.edu/research/faculty/enfuhui
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29 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Banta KL, Xu X, Chitre AS, Au-Yeung A, Takahashi C, O'Gorman WE, Wu TD, Mittman S, Cubas R, Comps-Agrar L, Fulzele A, Bennett EJ, Grogan JL, Hui E, Chiang EY, et al. Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8 T cell responses. Immunity. 55: 512-526.e9. PMID 35263569 DOI: 10.1016/j.immuni.2022.02.005  0.243
2021 Xu X, Masubuchi T, Cai Q, Zhao Y, Hui E. Molecular features underlying differential SHP1/SHP2 binding of immune checkpoint receptors. Elife. 10. PMID 34734802 DOI: 10.7554/eLife.74276  0.29
2020 Wu W, Zhou Q, Masubuchi T, Shi X, Li H, Xu X, Huang M, Meng L, He X, Zhu H, Gao S, Zhang N, Jing R, Sun J, Wang H, ... Hui E, et al. Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy. Cell. PMID 32730808 DOI: 10.1016/J.Cell.2020.07.018  0.389
2020 Xu X, Hou B, Fulzele A, Masubuchi T, Zhao Y, Wu Z, Hu Y, Jiang Y, Ma Y, Wang H, Bennett EJ, Fu G, Hui E. PD-1 and BTLA regulate T cell signaling differentially and only partially through SHP1 and SHP2. The Journal of Cell Biology. 219. PMID 32437509 DOI: 10.1083/Jcb.201905085  0.36
2019 Zhao Y, Lee CK, Lin CH, Gassen RB, Xu X, Huang Z, Xiao C, Bonorino C, Lu LF, Bui JD, Hui E. PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways. Immunity. PMID 31757674 DOI: 10.1016/J.Immuni.2019.11.003  0.34
2019 Sasmal DK, Feng W, Roy S, Leung P, He Y, Cai C, Cao G, Lian H, Qin J, Hui E, Schreiber H, Adams EJ, Huang J. TCR-pMHC bond conformation controls TCR ligand discrimination. Cellular & Molecular Immunology. PMID 31530899 DOI: 10.1038/S41423-019-0273-6  0.389
2019 Hui E. Understanding T cell signaling using membrane reconstitution. Immunological Reviews. 291: 44-56. PMID 31402497 DOI: 10.1111/Imr.12767  0.476
2018 Zhao Y, Harrison DL, Song Y, Ji J, Huang J, Hui E. Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells. Cell Reports. 24: 379-390.e6. PMID 29996099 DOI: 10.1016/J.Celrep.2018.06.054  0.343
2017 Carbone CB, Kern N, Fernandes RA, Hui E, Su X, Garcia KC, Vale RD. In vitro reconstitution of T cell receptor-mediated segregation of the CD45 phosphatase. Proceedings of the National Academy of Sciences of the United States of America. PMID 29042512 DOI: 10.1073/Pnas.1710358114  0.59
2017 Hui E, Cheung J, Zhu J, Su X, Taylor MJ, Wallweber HA, Sasmal DK, Huang J, Kim JM, Mellman I, Vale RD. T cell costimulatory receptor CD28 is a primary target for PD-1-mediated inhibition. Science (New York, N.Y.). PMID 28280247 DOI: 10.1126/Science.Aaf1292  0.534
2016 Su X, Ditlev JA, Hui E, Xing W, Banjade S, Okrut J, King DS, Taunton J, Rosen MK, Vale RD. Phase separation of signaling molecules promotes T cell receptor signal transduction. Science (New York, N.Y.). PMID 27056844 DOI: 10.1126/Science.Aad9964  0.571
2016 Su X, Ditlev J, Hui E, Banjade S, Okrut J, Taunton J, Rosen M, Vale R. Abstract A087: Phase separation of signaling molecules promotes T cell receptor signal transduction Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A087  0.586
2016 Su X, Ditlev J, Hui E, Rosen M, Vale R. Abstract B101: Mechanism of T cell activation by phase separation Cancer Immunology Research. 4. DOI: 10.1158/2326-6066.Imm2016-B101  0.57
2015 Chang CW, Hui E, Bai J, Bruns D, Chapman ER, Jackson MB. A structural role for the synaptobrevin 2 transmembrane domain in dense-core vesicle fusion pores. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 5772-80. PMID 25855187 DOI: 10.1523/Jneurosci.3983-14.2015  0.795
2014 Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 3: e01524. PMID 24569478 DOI: 10.7554/Elife.01524  0.799
2014 Hui E, Vale RD. In vitro membrane reconstitution of the T-cell receptor proximal signaling network. Nature Structural & Molecular Biology. 21: 133-42. PMID 24463463 DOI: 10.1038/Nsmb.2762  0.578
2014 Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment Elife. 2014. DOI: 10.7554/eLife.01524.001  0.807
2013 Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER. Author response: Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment Elife. DOI: 10.7554/Elife.01524.021  0.795
2011 Hui E, Gaffaney JD, Wang Z, Johnson CP, Evans CS, Chapman ER. Mechanism and function of synaptotagmin-mediated membrane apposition. Nature Structural & Molecular Biology. 18: 813-21. PMID 21642967 DOI: 10.1038/Nsmb.2075  0.798
2010 Zhang Z, Hui E, Chapman ER, Jackson MB. Regulation of exocytosis and fusion pores by synaptotagmin-effector interactions. Molecular Biology of the Cell. 21: 2821-31. PMID 20573977 DOI: 10.1091/Mbc.E10-04-0285  0.723
2009 Zhang Z, Hui E, Chapman ER, Jackson MB. Phosphatidylserine regulation of Ca2+-triggered exocytosis and fusion pores in PC12 cells. Molecular Biology of the Cell. 20: 5086-95. PMID 19828732 DOI: 10.1091/Mbc.E09-08-0691  0.755
2009 Hui E, Johnson CP, Yao J, Dunning FM, Chapman ER. Synaptotagmin-mediated bending of the target membrane is a critical step in Ca(2+)-regulated fusion. Cell. 138: 709-21. PMID 19703397 DOI: 10.1016/J.Cell.2009.05.049  0.799
2008 Gaffaney JD, Dunning FM, Wang Z, Hui E, Chapman ER. Synaptotagmin C2B domain regulates Ca2+-triggered fusion in vitro: critical residues revealed by scanning alanine mutagenesis. The Journal of Biological Chemistry. 283: 31763-75. PMID 18784080 DOI: 10.1074/Jbc.M803355200  0.793
2008 Paddock BE, Striegel AR, Hui E, Chapman ER, Reist NE. Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7458-66. PMID 18650324 DOI: 10.1523/Jneurosci.0197-08.2008  0.761
2008 Chicka MC, Hui E, Liu H, Chapman ER. Synaptotagmin arrests the SNARE complex before triggering fast, efficient membrane fusion in response to Ca2+. Nature Structural & Molecular Biology. 15: 827-35. PMID 18622390 DOI: 10.1038/Nsmb.1463  0.795
2008 Shahin V, Datta D, Hui E, Henderson RM, Chapman ER, Edwardson JM. Synaptotagmin perturbs the structure of phospholipid bilayers. Biochemistry. 47: 2143-52. PMID 18205405 DOI: 10.1021/Bi701879G  0.769
2006 Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, Chapman ER, Mothes W, Andrews NW. Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. The Journal of Cell Biology. 174: 997-1007. PMID 16982801 DOI: 10.1083/Jcb.200605004  0.754
2006 Hui E, Bai J, Chapman ER. Ca2+-triggered simultaneous membrane penetration of the tandem C2-domains of synaptotagmin I. Biophysical Journal. 91: 1767-77. PMID 16782782 DOI: 10.1529/Biophysj.105.080325  0.843
2005 Hui E, Bai J, Wang P, Sugimori M, Llinas RR, Chapman ER. Three distinct kinetic groupings of the synaptotagmin family: candidate sensors for rapid and delayed exocytosis. Proceedings of the National Academy of Sciences of the United States of America. 102: 5210-4. PMID 15793006 DOI: 10.1073/Pnas.0500941102  0.85
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