Stephen R. Byrn - Publications

Affiliations: 
Purdue University, West Lafayette, IN, United States 
Area:
Pharmaceutical Chemistry, Analytical Chemistry, Physical Chemistry

174 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Byrn SR, Chen XS, Smith PA. Predictive and Accelerated Formulation Design Using Synchrotron Methods. Aaps Pharmscitech. 20: 176. PMID 31037517 DOI: 10.1208/s12249-019-1375-2  0.56
2018 Nie H, Mo H, Byrn SR. Investigating the Physicochemical Stability of Highly Purified Darunavir Ethanolate Extracted from PREZISTA® Tablets. Aaps Pharmscitech. PMID 29869313 DOI: 10.1208/s12249-018-1036-x  0.4
2017 Kalra A, Luner P, Taylor LS, Byrn SR, Li T. Gaining Thermodynamic Insight from Distinct Glass Formation Kinetics of Structurally Similar Organic Compounds. Journal of Pharmaceutical Sciences. PMID 28648689 DOI: 10.1016/j.xphs.2017.06.012  0.4
2017 Kalra A, Tishmack P, Lubach JW, Munson E, Taylor LS, Byrn SR, Li T. Impact of Supramolecular Aggregation on the Crystallization Kinetics of Organic Compounds from the Supercooled Liquid State. Molecular Pharmaceutics. PMID 28485947 DOI: 10.1021/acs.molpharmaceut.7b00245  0.4
2017 de Araujo GL, Benmore CJ, Byrn SR. Local Structure of Ion Pair Interaction in Lapatinib Amorphous Dispersions characterized by Synchrotron X-Ray diffraction and Pair Distribution Function Analysis. Scientific Reports. 7: 46367. PMID 28397829 DOI: 10.1038/srep46367  0.44
2017 Zeller M, de Araujo GL, Parker T, Singh Rai A, Byrn SR. A new solvate of afatinib, a specific inhibitor of the ErbB family of tyrosine kinases. Acta Crystallographica. Section E, Crystallographic Communications. 73: 417-422. PMID 28316823 DOI: 10.1107/S2056989017002626  0.44
2017 Nie H, Byrn SR, Zhou QT. Stability of pharmaceutical salts in solid oral dosage forms. Drug Development and Industrial Pharmacy. 1-43. PMID 28276282 DOI: 10.1080/03639045.2017.1304960  0.4
2016 Nie H, Xu W, Taylor LS, Marsac PJ, Byrn SR. Crystalline solid dispersion-a strategy to slowdown salt disproportionation in solid state formulations during storage and wet granulation. International Journal of Pharmaceutics. PMID 27979765 DOI: 10.1016/j.ijpharm.2016.12.014  0.4
2016 Nie H, Su Y, Zhang M, Song Y, Leone A, Taylor LS, Marsac PJ, Li T, Byrn SR. Solid-State Spectroscopic Investigation of Molecular Interactions between Clofazimine and Hypromellose Phthalate in Amorphous Solid Dispersions. Molecular Pharmaceutics. PMID 27653759 DOI: 10.1021/acs.molpharmaceut.6b00740  0.4
2016 Nie H, Xu W, Ren J, Taylor LS, Marsac PJ, John CT, Byrn SR. Impact of Metallic Stearates on Disproportionation of Hydrochloride Salts of Weak Bases in Solid-State Formulations. Molecular Pharmaceutics. PMID 27542728 DOI: 10.1021/acs.molpharmaceut.6b00630  1
2016 Weber JK, Benmore CJ, Suthar KJ, Tamalonis AJ, Alderman OL, Sendelbach S, Kondev V, Yarger J, Rey CA, Byrn SR. Using containerless methods to develop amorphous pharmaceuticals. Biochimica Et Biophysica Acta. PMID 27062908 DOI: 10.1016/j.bbagen.2016.03.037  1
2016 Braun DE, Nartowski KP, Khimyak YZ, Morris KR, Byrn SR, Griesser UJ. Structural Properties, Order-Disorder Phenomena and Phase Stability of Orotic Acid Crystal Forms. Molecular Pharmaceutics. PMID 26741914 DOI: 10.1021/acs.molpharmaceut.5b00856  1
2015 Nie H, Liu Z, Marks BC, Taylor LS, Byrn SR, Marsac PJ. Analytical approaches to investigate salt disproportionation in tablet matrices by Raman spectroscopy and Raman mapping. Journal of Pharmaceutical and Biomedical Analysis. 118: 328-337. PMID 26590700 DOI: 10.1016/j.jpba.2015.10.024  1
2015 Nie H, Mo H, Zhang M, Song Y, Fang K, Taylor LS, Li T, Byrn SR. Investigating the Interaction Pattern and Structural Elements of a Drug-Polymer Complex at the Molecular Level. Molecular Pharmaceutics. 12: 2459-68. PMID 25988812 DOI: 10.1021/acs.molpharmaceut.5b00162  1
2015 Penumetcha SS, Byrn SR, Morris KR. Relaxation Kinetic Study of Eudragit® NM30D Film Based on Complex Modulus Formalism. Aaps Pharmscitech. PMID 25735736 DOI: 10.1208/s12249-015-0289-x  1
2015 Byrn SR, Haskell RJ. Efficient laboratory methods to assess risk and design formulations Discovering and Developing Molecules With Optimal Drug-Like Properties. 241-261. DOI: 10.1007/978-1-4939-1399-2_8  1
2015 Byrn SR. Predictive approaches to establishing, understanding, and communicating risk with emphasis on early development Discovering and Developing Molecules With Optimal Drug-Like Properties. 195-208. DOI: 10.1007/978-1-4939-1399-2_6  1
2015 Templeton AC, Byrn SR, Haskell RJ, Prisinzano TE. Discovering and developing molecules with optimal drug-like properties Discovering and Developing Molecules With Optimal Drug-Like Properties. 1-511. DOI: 10.1007/978-1-4939-1399-2  1
2013 Lee J, Boerrigter SX, Jung YW, Byun Y, Yuk SH, Byrn SR, Lee EH. Organic vapor sorption method of isostructural solvates and polymorph of tenofovir disoproxil fumarate. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 50: 253-62. PMID 23872626 DOI: 10.1016/j.ejps.2013.07.004  1
2013 Gurvich VJ, Byrn SR. NIPTE: a multi-university partnership supporting academic drug development. Drug Discovery Today. 18: 916-21. PMID 23732177 DOI: 10.1016/j.drudis.2013.05.014  1
2013 Benmore CJ, Weber JK, Tailor AN, Cherry BR, Yarger JL, Mou Q, Weber W, Neuefeind J, Byrn SR. Structural characterization and aging of glassy pharmaceuticals made using acoustic levitation. Journal of Pharmaceutical Sciences. 102: 1290-300. PMID 23381910 DOI: 10.1002/jps.23464  1
2013 Fortunak JMD, Byrn SR, Dyson B, Ekeocha Z, Ellison T, King CL, Kulkarni AA, Lee M, Conrad C, Thompson K. An efficient, green chemical synthesis of the malaria drug, piperaquine Tropical Journal of Pharmaceutical Research. 12: 791-798. DOI: 10.4314/tjpr.v12i5.20  1
2013 Weber JKR, Benmore CJ, Tailor AN, Tumber SK, Neuefeind J, Cherry B, Yarger JL, Mou Q, Weber W, Byrn SR. A neutron-X-ray, NMR and calorimetric study of glassy Probucol synthesized using containerless techniques Chemical Physics. 424: 89-92. DOI: 10.1016/j.chemphys.2013.05.019  1
2012 Lee EH, Byrn SR, Pinal R. The solution properties of mefenamic acid and a closely related analogue are indistinguishable in polar solvents but significantly different in nonpolar environments. Journal of Pharmaceutical Sciences. 101: 4529-39. PMID 22972701 DOI: 10.1002/jps.23316  1
2012 Trasi NS, Byrn SR. Mechanically induced amorphization of drugs: a study of the thermal behavior of cryomilled compounds. Aaps Pharmscitech. 13: 772-84. PMID 22585375 DOI: 10.1208/s12249-012-9801-8  1
2012 Weber RJ, Benmore CJ, Tumber SK, Tailor AN, Rey CA, Taylor LS, Byrn SR. Acoustic levitation: recent developments and emerging opportunities in biomaterials research. European Biophysics Journal : Ebj. 41: 397-403. PMID 22038123 DOI: 10.1007/s00249-011-0767-3  1
2012 Byrn SR, Henck JO. Optimizing the physical form - Opportunities and limitations Drug Discovery Today: Technologies. 9. DOI: 10.1016/j.ddtec.2012.03.006  1
2011 Su Z, Luthra S, Krzyzaniak JF, Agra-Kooijman DM, Kumar S, Byrn SR, Shalaev EY. Crystalline, liquid crystalline, and isotropic phases of sodium deoxycholate in water. Journal of Pharmaceutical Sciences. 100: 4836-44. PMID 21721005 DOI: 10.1002/jps.22690  1
2011 Byrn SR, Tishmack PA, Milton MJ, van de Velde H. Analysis of two commercially available bortezomib products: differences in assay of active agent and impurity profile. Aaps Pharmscitech. 12: 461-7. PMID 21455817 DOI: 10.1208/s12249-010-9554-1  1
2011 Trasi NS, Boerrigter SX, Byrn SR, Carvajal TM. Investigating the effect of dehydration conditions on the compactability of glucose. International Journal of Pharmaceutics. 406: 55-61. PMID 21232587 DOI: 10.1016/j.ijpharm.2010.12.042  1
2011 Yamauchi M, Lee EH, Otte A, Byrn SR, Carvajal MT. Contrasting the surface and bulk properties of anhydrate and dehydrated hydrate materials Crystal Growth and Design. 11: 692-698. DOI: 10.1021/cg101098v  1
2011 Henck JO, Byrn SR. Solid state chemistry: The impact on drug development, manufacturing, and IP protection Contract Pharma 1
2010 Lee EH, Byrn SR. Stabilization of metastable flufenamic acid by inclusion of mefenamic acid: solid solution or epilayer? Journal of Pharmaceutical Sciences. 99: 4013-22. PMID 20589947 DOI: 10.1002/jps.22250  1
2010 Byrn SR, Zografi G, Chen X. Accelerating proof of concept for small molecule drugs using solid-state chemistry. Journal of Pharmaceutical Sciences. 99: 3665-75. PMID 20589946 DOI: 10.1002/jps.22215  1
2010 Li H, Wen H, Stowell JG, Morris KR, Byrn SR. Crystal quality and physical reactivity in the case of flufenamic acid (FFA). Journal of Pharmaceutical Sciences. 99: 3839-48. PMID 20589945 DOI: 10.1002/jps.22221  1
2010 Trasi NS, Boerrigter SX, Byrn SR. Investigation of the milling-induced thermal behavior of crystalline and amorphous griseofulvin. Pharmaceutical Research. 27: 1377-89. PMID 20490628 DOI: 10.1007/s11095-010-0129-3  1
2010 Mao C, Chamarthy SP, Byrn SR, Pinal R. Theoretical and experimental considerations on the enthalpic relaxation of organic glasses using differential scanning calorimetry. The Journal of Physical Chemistry. B. 114: 269-79. PMID 20017467 DOI: 10.1021/jp906633k  1
2010 Chen X, Stowell JG, Morris KR, Byrn SR. Quantitative study of solid-state acid-base reactions between polymorphs of flufenamic acid and magnesium oxide using X-ray powder diffraction. Journal of Pharmaceutical and Biomedical Analysis. 51: 866-74. PMID 19906502 DOI: 10.1016/j.jpba.2009.09.021  1
2010 Atassi F, Mao C, Masadeh AS, Byrn SR. Solid-state characterization of amorphous and mesomorphous calcium ketoprofen. Journal of Pharmaceutical Sciences. 99: 3684-97. PMID 19780126 DOI: 10.1002/jps.21925  1
2010 Lee EH, Boerrigter SXM, Byrn SR. Epitaxy of a structurally related compound on the (100) faces of flufenamic acid form i and iii single crystals Crystal Growth and Design. 10: 518-527. DOI: 10.1021/cg900549h  1
2010 Lee EH, Smith DT, Fanwick PE, Byrn SR. Characterization and anisotropic lattice expansion/contraction of polymorphs of tenofovir disoproxil fumarate Crystal Growth and Design. 10: 2314-2322. DOI: 10.1021/cg1000667  1
2009 Joshi V, Morris KR, Byrn SR, Carvajal MT. Evaluation of the use of Ea (activation energy) as a quantitative indicator of physical stability of indomethacin solvates: Methanolate and tertiary butyl alcohol solvate Crystal Growth and Design. 9: 3359-3366. DOI: 10.1021/cg800750g  1
2008 Chongcharoen W, Byrn SR, Sutanthavibul N. Solid state interconversion between anhydrous norfloxacin and its hydrates. Journal of Pharmaceutical Sciences. 97: 473-89. PMID 17924417 DOI: 10.1002/jps.21165  1
2008 Lee EH, Boerrigter SXM, Rumondor ACF, Chamarthy SP, Byrn SR. Formation and solid-state characterization of a salt-induced metastable polymorph of flufenamic acid Crystal Growth and Design. 8: 91-97. DOI: 10.1021/cg7008607  1
2007 Hu Y, Wikström H, Byrn SR, Taylor LS. Estimation of the transition temperature for an enantiotropic polymorphic system from the transformation kinetics monitored using Raman spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 45: 546-51. PMID 17851013 DOI: 10.1016/j.jpba.2007.07.028  1
2007 McBride JM, Smith DT, Byrn SR, Borgens RB, Shi R. 4-Aminopyridine derivatives enhance impulse conduction in guinea-pig spinal cord following traumatic injury. Neuroscience. 148: 44-52. PMID 17629412 DOI: 10.1016/j.neuroscience.2007.05.039  1
2007 Li H, Stowell JG, He X, Morris KR, Byrn SR. Investigations on solid-solid phase transformation of 5-methyl-2-[(4-methyl-2-nitrophenyl)amino]-3-thiophenecarbonitrile. Journal of Pharmaceutical Sciences. 96: 1079-89. PMID 17455331 DOI: 10.1002/jps.20937  1
2007 Henck JO, Byrn SR. Designing a molecular delivery system within a preclinical timeframe. Drug Discovery Today. 12: 189-99. PMID 17331883 DOI: 10.1016/j.drudis.2007.01.006  1
2006 Hu Y, Wikström H, Byrn SR, Taylor LS. Analysis of the effect of particle size on polymorphic quantitation by Raman spectroscopy. Applied Spectroscopy. 60: 977-84. PMID 17002821 DOI: 10.1366/000370206778397272  1
2006 Mao C, Prasanth Chamarthy S, Byrn SR, Pinal R. A calorimetric method to estimate molecular mobility of amorphous solids at relatively low temperatures. Pharmaceutical Research. 23: 2269-76. PMID 16933097 DOI: 10.1007/s11095-006-9071-9  1
2006 Atassi F, Byrn SR. General trends in the desolvation behavior of calcium salts. Pharmaceutical Research. 23: 2405-12. PMID 16927185 DOI: 10.1007/s11095-006-9015-4  1
2006 Lee EH, Byrn SR, Carvajal MT. Additive-induced metastable single crystal of mefenamic acid. Pharmaceutical Research. 23: 2375-80. PMID 16927183 DOI: 10.1007/s11095-006-9045-y  1
2006 Crooks PA, Kottayil SG, Al-Ghananeem AM, Byrn SR, Butterfield DA. Opiate receptor binding properties of morphine-, dihydromorphine-, and codeine 6-O-sulfate ester congeners. Bioorganic & Medicinal Chemistry Letters. 16: 4291-5. PMID 16777416 DOI: 10.1016/j.bmcl.2006.05.060  1
2006 Terakita A, Byrn SR. Structure and physical stability of hydrates and thermotropic mesophase of calcium benzoate. Journal of Pharmaceutical Sciences. 95: 1162-72. PMID 16570305 DOI: 10.1002/jps.20589  1
2006 McBride JM, Smith DT, Byrn SR, Borgens RB, Shi R. Dose responses of three 4-aminopyridine derivatives on axonal conduction in spinal cord trauma. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 27: 237-42. PMID 16297607 DOI: 10.1016/j.ejps.2005.10.003  1
2006 Li H, Stowell JG, Borchardt TB, Byrn SR. Synthesis, conformational polymorphism, and construction of a G-T diagram of 2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile Crystal Growth and Design. 6: 2469-2474. DOI: 10.1021/cg050608p  1
2005 Qiu Z, Stowell JG, Cao W, Morris KR, Byrn SR, Carvajal MT. Effect of milling and compression on the solid-state Maillard reaction. Journal of Pharmaceutical Sciences. 94: 2568-80. PMID 16200560 DOI: 10.1002/jps.20448  1
2005 Qiu Z, Stowell JG, Morris KR, Byrn SR, Pinal R. Kinetic study of the Maillard reaction between metoclopramide hydrochloride and lactose. International Journal of Pharmaceutics. 303: 20-30. PMID 16126356 DOI: 10.1016/j.ijpharm.2005.06.016  1
2005 Smith DT, Shi R, Borgens RB, McBride JM, Jackson K, Byrn SR. Development of novel 4-aminopyridine derivatives as potential treatments for neurological injury and disease. European Journal of Medicinal Chemistry. 40: 908-17. PMID 16055230 DOI: 10.1016/j.ejmech.2005.04.017  1
2005 Chen X, Griesser UJ, Te RL, Pfeiffer RR, Morris KR, Stowell JG, Byrn SR. Analysis of the acid-base reaction between solid indomethacin and sodium bicarbonate using infrared spectroscopy, X-ray powder diffraction, and solid-state nuclear magnetic resonance spectroscopy. Journal of Pharmaceutical and Biomedical Analysis. 38: 670-7. PMID 15967295 DOI: 10.1016/j.jpba.2005.02.017  1
2005 Byrn SR, Bates S, Ivanisevic I. Regulatory aspects of X-ray powder diffraction, part 1 American Pharmaceutical Review. 8: 55-59.  1
2005 Byrn SR, Bates S, Ivanisevic I. Regulatory aspects of X-ray powder diffraction - Part 2 American Pharmaceutical Review. 8: 137-141.  1
2004 Davis TD, Peck GE, Stowell JG, Morris KR, Byrn SR. Modeling and monitoring of polymorphic transformations during the drying phase of wet granulation. Pharmaceutical Research. 21: 860-6. PMID 15180346 DOI: 10.1023/B:PHAM.0000026440.00508.cf  1
2004 Grant DJ, Byrn SR. A timely re-examination of drug polymorphism in pharmaceutical development and regulation. Advanced Drug Delivery Reviews. 56: 237-9. PMID 14962580 DOI: 10.1016/j.addr.2003.12.001  0.44
2003 Davis TD, Morris KR, Huang H, Peck GE, Stowell JG, Eisenhauer BJ, Hilden JL, Gibson D, Byrn SR. In situ monitoring of wet granulation using online X-ray powder diffraction. Pharmaceutical Research. 20: 1851-7. PMID 14661932 DOI: 10.1023/B:PHAM.0000003385.20030.9a  1
2003 Newman AW, Byrn SR. Solid-state analysis of the active pharmaceutical ingredient in drug products. Drug Discovery Today. 8: 898-905. PMID 14554018 DOI: 10.1016/S1359-6446(03)02832-0  1
2003 Tishmack PA, Bugay DE, Byrn SR. Solid-state nuclear magnetic resonance spectroscopy--pharmaceutical applications. Journal of Pharmaceutical Sciences. 92: 441-74. PMID 12587108 DOI: 10.1002/jps.10307  1
2003 Te RL, Griesser UJ, Morris KR, Byrn SR, Stowell JG. X-ray Diffraction and Solid-State NMR Investigation of the Single-Crystal to Single-Crystal Dehydration of Thiamine Hydrochloride Monohydrate Crystal Growth and Design. 3: 997-1004. DOI: 10.1021/cg0340749  1
2003 Reutzel-Edens SM, Bush JK, Magee PA, Stephenson GA, Byrn SR. Anhydrates and Hydrates of Olanzapine: Crystallization, Solid-State Characterization, and Structural Relationships Crystal Growth and Design. 3: 897-907. DOI: 10.1021/cg034055z  1
2002 Chen X, Morris KR, Griesser UJ, Byrn SR, Stowell JG. Reactivity differences of indomethacin solid forms with ammonia gas. Journal of the American Chemical Society. 124: 15012-9. PMID 12475345 DOI: 10.1021/ja017662o  1
2002 Byrn SR, Pfeiffer RR, Stowell JG. Polymorphs, regulations, crystallization, and solid-state chemistry American Pharmaceutical Review. 5: 92-99.  1
2002 Chen X, Li T, Morris KR, Byrn SR. Crystal packing and chemical reactivity of two polymorphs of flufenamic acid with ammonia Molecular Crystals and Liquid Crystals Science and Technology Section a: Molecular Crystals and Liquid Crystals. 381: 121-131.  1
2001 Byrn SR, Xu W, Newman AW. Chemical reactivity in solid-state pharmaceuticals: Formulation implications Advanced Drug Delivery Reviews. 48: 115-136. PMID 11325479 DOI: 10.1016/S0169-409X(01)00102-8  1
2001 He X, Griesser UJ, Stowell JG, Borchardt TB, Byrn SR. Conformational color polymorphism and control of crystallization of 5-methyl-2-[(4-methyl-2-nitrophenyl)amino]-3-thiophenecarbonitrile. Journal of Pharmaceutical Sciences. 90: 371-88. PMID 11170030 DOI: 10.1002/1520-6017(200103)90:3<371::AID-JPS12>3.0.CO;2-N  1
2001 He X, Griesser UJ, Stowell JG, Borchardt TB, Byrn SR. Variable pH kinetics: An easy determination of pH-rate profile Journal of Pharmaceutical Sciences. 90: 270-274. PMID 11170020 DOI: 10.1002/1520-6017(200103)90:3<270::AID-JPS2>3.0.CO;2-#  1
2001 He X, Stowell JG, Morris KR, Pfeiffer RR, Li H, Stahly GP, Byrn SR. Stabilization of a Metastable Polymorph of 4-Methyl-2-nitroacetanilide by Isomorphic Additives Crystal Growth and Design. 1: 305-312. DOI: 10.1021/cg0055225  1
2001 Suryanarayanan R, Byrn SR. Advanced Drug Delivery Reviews: Preface Advanced Drug Delivery Reviews. 48: 1-2. DOI: 10.1016/S0169-409X(01)00096-5  1
2001 Pagola S, Stephens PW, He X, Byrn SR. Crystal structure solution of the dark red, light red and orange polymorphs of 5-methyl-2-[(2-nitro-4-methylphenyl)amino]-3-thiophenecarbonitrile by high resolution X-ray powder diffraction and simulated annealing techniques Materials Science Forum. 378: 789-794.  1
2000 Guo Y, Byrn SR, Zografi G. Effects of lyophilization on the physical characteristics and chemical stability of amorphous quinapril hydrochloride Pharmaceutical Research. 17: 930-935. PMID 11028937 DOI: 10.1023/A:1007519003070  1
2000 Morris KR, Stowell JG, Byrn SR, Placette AW, Davis TD, Peck GE. Accelerated fluid bed drying using NIR monitoring and phenomenological modeling. Drug Development and Industrial Pharmacy. 26: 985-8. PMID 10914323 DOI: 10.1081/DDC-100101326  1
2000 Guo Y, Byrn SR, Zografi G. Physical characteristics and chemical degradation of amorphous quinapril hydrochloride Journal of Pharmaceutical Sciences. 89: 128-143. PMID 10664545 DOI: 10.1002/(SICI)1520-6017(200001)89:1<128::AID-JPS13>3.0.CO;2-Z  1
2000 Yu L, Stephenson GA, Mitchell CA, Bunnell CA, Snorek SV, Bowyer JJ, Borchardt TB, Stowell JG, Byrn SR. Thermochemistry and conformational polymorphism of a hexamorphic crystal system Journal of the American Chemical Society. 122: 585-591. DOI: 10.1021/ja9930622  1
1998 Chongprasert S, Griesser UJ, Bottorff AT, Williams NA, Byrn SR, Nail SL. Effects of freeze-dry processing conditions on the crystallization of pentamidine isethionate Journal of Pharmaceutical Sciences. 87: 1155-1160. PMID 9724570 DOI: 10.1021/js970342b  1
1998 Morris KR, Nail SL, Peck GE, Byrn SR, Griesser UJ, Stowell JG, Hwang SJ, Park K. Advances in pharmaceutical materials and processing Pharmaceutical Science and Technology Today. 1: 235-245. DOI: 10.1016/S1461-5347(98)00062-5  1
1998 Joshi V, Stowell JG, Byrn SR. Solid-state stability of indomethacin solvates Molecular Crystals and Liquid Crystals Science and Technology Section a: Molecular Crystals and Liquid Crystals. 313: 265-270.  1
1998 Borchardt TB, Stowell JG, Byrn SR. The crystallization of 5-methyl-2-[(2-nitrophenyl)amino]-3-thiophenecarbonitrile in the presence of structurally similar compounds Molecular Crystals and Liquid Crystals Science and Technology Section a: Molecular Crystals and Liquid Crystals. 313: 271-276.  1
1997 Stephenson GA, Stowell JG, Toma PH, Pfeiffer RR, Byrn SR. Solid-state investigations of erythromycin A dihydrate: structure, NMR spectroscopy, and hygroscopicity. Journal of Pharmaceutical Sciences. 86: 1239-44. PMID 9383733 DOI: 10.1021/js9701667  1
1997 Stahly GP, McKenzie AT, Andres MC, Russell CA, Byrn SR, Johnson P. Determination of the optical purity of ibuprofen using X-ray powder diffraction [2] Journal of Pharmaceutical Sciences. 86: 970-971. PMID 9269877 DOI: 10.1021/js9700715  1
1997 Kim C, MacKellar WC, Cho NM, Byrn SR, Morré DJ. Impermeant antitumor sulfonylurea conjugates that inhibit plasma membrane NADH oxidase and growth of HeLa cells in culture. Identification of binding proteins from sera of cancer patients. Biochimica Et Biophysica Acta. 1324: 171-81. PMID 9092704 DOI: 10.1016/S0005-2736(96)00219-2  1
1997 Shalaev EY, Shalaeva M, Byrn SR, Zografi G. Effects of processing on the solid-state methyl transfer of tetraglycine methyl ester International Journal of Pharmaceutics. 152: 75-88. DOI: 10.1016/S0378-5173(97)00068-9  1
1997 Stephenson GA, Pfeiffer RR, Byrn SR. Solid-state investigation of the tautomerism of acetohexamide International Journal of Pharmaceutics. 146: 93-99. DOI: 10.1016/S0378-5173(96)04775-8  1
1997 Wahle MC, Byrn SR. Hydrated structures of N-methylated cholamide derivatives Acta Crystallographica Section C: Crystal Structure Communications. 53: 334-339.  1
1997 Shalaev EY, Byrn SR, Zografi G. Single-phase and heterophase solid-state chemical kinetics of thermally induced methyl transfer in tetraglycine methyl ester International Journal of Chemical Kinetics. 29: 339-348.  1
1997 Huang KS, Britton D, Etter MC, Byrn SR. A novel class of phenol-pyridine co-crystals for second harmonic generation Journal of Materials Chemistry. 7: 713-720.  1
1997 Huang KS, Stowell JG, Byrn SR. 3-(4-Nitroanilino)-2-cyclopenten-1-one Acta Crystallographica Section C: Crystal Structure Communications. 53: 1717-1719.  1
1997 Wahle MC, Fanwick PE, Byrn SR. Cholamide dihydrate Acta Crystallographica Section C: Crystal Structure Communications. 53: 480-482.  1
1997 Xu W, Wahle MC, Stowell JG, Byrn SR. Spirapril hydrochloride hydrate Acta Crystallographica Section C: Crystal Structure Communications. 53: 1917-1919.  1
1996 Wahle MC, Byrn SR. 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid methyl ester ethanolate (methyl cholate ethanolate) Acta Crystallographica Section C: Crystal Structure Communications. 52: 2500-2502.  1
1996 Wahle MC, Byrn SR. Sodium cholate methanolate and sodium cholate 2-propanolate Acta Crystallographica Section C: Crystal Structure Communications. 52: 2495-2499.  1
1996 Huang KS, Britton D, Etter MC, Byrn SR. Synthesis, polymorphic characterization and structural comparisons of the non-linear optically active and inactive forms of polymorphs of 3-(nitroanilino)cycloalk-2-en-1-ones Journal of Materials Chemistry. 6: 123-129.  1
1996 Wahle MC, Stowell JG, Byrn SR. Sodium 3α,7α,12α-trihydroxy-5β-cholan-24-oate ethanolate (sodium cholate ethanolate) Acta Crystallographica Section C: Crystal Structure Communications. 52: 325-328.  1
1996 Stephenson GA, Wozniak TJ, Stowell JG, Byrn SR. Nizatidine, N-[2-[[[2-[(dimethylamino)methyl]-4-thiazolyl]methyl]thio]ethyl]-N′- methyl-2-nitro-1,1-ethenediamine Journal of Molecular Structure. 380: 93-100.  1
1995 Byrn SR, Stowell JG. Drug targeting using conjugates: The importance of pharmaceutical chemistry Journal of Drug Targeting. 3: 239-241. PMID 8820996 DOI: 10.3109/10611869509015951  1
1995 Stephenson GA, Borchardt TB, Byrn SR, Bowyer J, Bunnell CA, Snorek SV, Yu L. Conformational and color polymorphism of 5‐methyl‐2‐[(2‐nitrophenyl)amino]‐3‐thiophenecarbonitrile Journal of Pharmaceutical Sciences. 84: 1385-1386. PMID 8587060 DOI: 10.1002/jps.2600841122  1
1995 Akers MJ, Milton N, Byrn SR, Nail SL. Glycine Crystallization During Freezing: The Effects of Salt Form, pH, and Ionic Strength Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists. 12: 1457-1461. PMID 8584480 DOI: 10.1023/A:1016223101872  1
1995 Saleki‐Gerhardt A, Stoweell JG, Byrn SR, Zografi G. Hydration and dehydration of crystalline and amorphous forms of raffinose Journal of Pharmaceutical Sciences. 84: 318-323. PMID 7616371 DOI: 10.1002/jps.2600840311  1
1995 Huang KS, Britton D, Etter MC, Byrn SR. Polymorphic characterization and structural comparisons of the non-linear optically active and inactive forms of two polymorphs of 1,3-bis(m-nitrophenyl)urea Journal of Materials Chemistry. 5: 379-383.  1
1994 Ma WP, Hamilton SE, Stowell JG, Byrn SR, Davisson VJ. Sequence specific cleavage of messenger RNA by a modified ribonuclease H. Bioorganic & Medicinal Chemistry. 2: 169-79. PMID 7522907 DOI: 10.1016/S0968-0896(00)82012-X  1
1994 Stephenson GA, Stowell JG, Toma PH, Dorman DE, Greene JR, Byrn SR. Solid-state analysis of polymorphic, isomorphic, and solvated forms of dirithromycin Journal of the American Chemical Society. 116: 5766-5773. DOI: 10.1021/ja00092a030  1
1994 Byrn SR, Pfeiffer RR, Stephenson G, Grant DJW, Gleason WB. Solid-state pharmaceutical chemistry Chemistry of Materials. 6: 1148-1158.  1
1994 Toma PH, Kelley MP, Borchardt TB, Byrn SR, Kahr B. Chromoisomers and polymorphs of 9-phenylacridinium hydrogen sulfate Chemistry of Materials. 6: 1317-1324.  1
1993 Saindon PJ, Cauchon NS, Sutton PA, Chang CJ, Peck GE, Byrn SR. Solid-state nuclear magnetic resonance (NMR) spectra of pharmaceutical dosage forms. Pharmaceutical Research. 10: 197-203. PMID 8456065 DOI: 10.1023/A:1018922407786  1
1993 Dalla Riva Toma JM, Toma PH, Fanwick PE, Bergstrom DE, Byrn SR. Photochemical synthesis and crystal structure of two potentially useful metal carbonyl complexes: pentacarbonyl(η2-cis-cyclooctene)-tungsten(0) and tetracarbonylbis(η2-cis-cyclooctene)tungsten(0) Journal of Crystallographic and Spectroscopic Research. 23: 41-47. DOI: 10.1007/BF01161286  1
1992 Stowell JG, Toma PH, Byrn SR. The structure of MK-571 (form I) at 170 K and conformational analysis by molecular modeling Bioorganic and Medicinal Chemistry Letters. 2: 185-190. DOI: 10.1016/S0960-894X(01)80447-9  1
1991 Byrn SR, Carlson DV, Chen JK, Cushman MS, Goldman ME, Ma WP, Pidgeon CL, Ray KA, Stowell JG, Weith HL. Drug-oligonucleotide conjugates Advanced Drug Delivery Reviews. 6: 287-308. DOI: 10.1016/0169-409X(91)90022-5  1
1990 Martinez H, Byrn SR, Pfeiffer RR. Solid-state chemistry and crystal structure of cefaclor dihydrate. Pharmaceutical Research. 7: 147-53. PMID 2308894 DOI: 10.1023/A:1015824701581  1
1990 Shieh TL, Hoyos P, Kolodziej E, Stowell JG, Baird WM, Byrn SR. Properties of the nucleic acid photoaffinity labeling agent 3-azidoamsacrine. Journal of Medicinal Chemistry. 33: 1225-30. PMID 2157014  1
1990 Toma PH, Ray KA, Stowell JG, Byrn SR. 9‐Acridineethanol Acta Crystallographica Section C. 46: 1573-1575. DOI: 10.1107/S0108270190002839  1
1990 Ma WW, Anderson JE, McKenzie AT, Byrn SR, McLaughlin JL, Hudson MS. Tubulosine: An antitumor constituent of Pogonopus speciosus Journal of Natural Products. 53: 1009-1014.  1
1990 Pidgeon C, Weith HL, Darbishire-Weith D, Cushman M, Byrn SR, Chen JK, Stowell JG, Ray K, Carlson D. Synthesis and liposome encapsulation of antisense oligonucleotide-intercalator conjugates Annals of the New York Academy of Sciences. 616: 593-596.  1
1989 Alkofahi A, Ma WW, McKenzie AT, Byrn SR, Mclaughlin JL. Goniotriol from Goniothalamus giganteus Journal of Natural Products. 52: 1371-1373. PMID 2614426  1
1989 Lassalle I, Hoyos PA, Byrn SR, Weith HL. Sequence preference of acridine interaction with single and double stranded octadeoxyribonucleotides Nucleosides and Nucleotides. 8: 1049-1050. DOI: 10.1080/07328318908054276  1
1989 Cushman M, Patrick DA, Toma PH, Byrn SR. A novel ring system arising from intramolecular oxidative cyclization of 8-(4-pentenyl)dihydroberberine Tetrahedron Letters. 30: 7161-7164. DOI: 10.1016/S0040-4039(01)93923-1  1
1988 Mossa JS, Cassady JM, Kozlowski JF, Zennie TM, Antoun MD, Pellechia MG, McKenzie AT, Byrn SR. Novel 6,7-seco-6,11-cyclolabdane diterpenes from cluytia richardiana Tetrahedron Letters. 29: 3627-3630. DOI: 10.1016/S0040-4039(00)82139-5  1
1988 Byrn SR, Sutton PA, Tobias B, Frye J, Main P. The crystal structure, solid-state NMR spectra, and oxygen reactivity of five crystal forms of prednisolone tert-butylacetate Journal of the American Chemical Society. 110: 1609-1614.  1
1987 Byrn SR, Perrier P, Lin CT, Martinez H, Pfeiffer RR. The solid-state decarboxylation of the diammonium salt of moxalactam. Pharmaceutical Research. 4: 137-41. PMID 3509137 DOI: 10.1023/A:1016471003785  1
1987 Riggs RM, McKenzie AT, Byrn SR, Nichols DE, Foreman MM, Truex LL. Effect of beta-alkyl substitution on D-1 dopamine agonist activity: absolute configuration of beta-methyldopamine. Journal of Medicinal Chemistry. 30: 1914-8. PMID 3309317  1
1987 Byrn SR, Kessler DW. The solid state reactivity of the crystal forms of hydrocortisone esters Tetrahedron. 43: 1335-1343. DOI: 10.1016/S0040-4020(01)90254-6  1
1987 Ho DK, McKenzie AT, Byrn SR, Cassady JM. O5-methyl-(±)-(2′R,3′,S)-psorospermin Journal of Organic Chemistry. 52: 342-347.  1
1987 Hedstrand DM, Byrn SR, McKenzie AT, Fuchs PL. Use of an axial β-face thiomethyl control element in intramolecular conjugate additions. Synthesis of a tricyclic bruceantin precursor Journal of Organic Chemistry. 52: 592-598.  1
1987 Habib AM, Ho DK, Masuda S, McCloud T, Reddy KS, Aboushoer M, McKenzie A, Byrn SR, Chang CJ, Cassady JM. Structure and stereochemistry of Psorospermin and related cytotoxic dihydrofuranoxanthones from Psorospermum febrifugum Journal of Organic Chemistry. 52: 412-418.  1
1986 Byrn SR, McKenzie AT, Hassan MMA, Al-Badr AA. Conformation of glyburide in the solid state and in solution Journal of Pharmaceutical Sciences. 75: 596-600. PMID 3016235 DOI: 10.1002/jps.2600750615  1
1985 Byrn SR, Gray G, Pfeiffer RR, Frye J. Analysis of solid-state Carbon-13 NMR spectra of polymorphs (benoxaprofen and nabilone) and pseudopolymorphs (cefazolin). Journal of Pharmaceutical Sciences. 74: 565-8. PMID 2991492 DOI: 10.1002/jps.2600740516  1
1985 Byrn SR. Chapter 29. Solid State Organic Chemistry and Drug Stability Annual Reports in Medicinal Chemistry. 20: 287-294. DOI: 10.1016/S0065-7743(08)61055-6  1
1985 El-Zayat AAE, Ferrigni NR, McCloud TG, McKenzie AT, Byrn SR, Cassady JM, Chang Cj, McLaughlin JL. Goniothalenol: a novel, bioactive, tetrahydrofurano-2-pyrone from goniothalamus giganteus (annonaceae) Tetrahedron Letters. 26: 955-956. DOI: 10.1016/S0040-4039(00)98484-3  1
1985 Mossa JS, Cassady JM, Antoun MD, Byrn SR, McKenzie AT, Kozlowski JF, Main P. Saudin, a hypoglycemic diterpenoid with a novel 6,7-secolabdane carbon skeleton, from Cluytia richardiana Journal of Organic Chemistry. 50: 916-918.  1
1984 Stewart BA, Midland SL, Byrn SR. Degradation of crystalline ergocalciferol [vitamin D2, (3 beta,5Z,22E)-9,10-secoergosta-5,7,10(19),22-tetra en-3-ol]. Journal of Pharmaceutical Sciences. 73: 1322-3. PMID 6333506 DOI: 10.1002/jps.2600730940  1
1984 Lassalle I, Weith HL, Byrn SR. Synthesis, thermodynamics and drug interactions of model octanucleotides Federation Proceedings. 43.  1
1984 Hoyos PA, Baird WM, Byrn SR. Relationship of side chain to the mutagenicity of a series of 9-aminoacridines in S. typhimurium and Chinese hamster V79 cells Federation Proceedings. 43.  1
1984 Cassady JM, Lightner TK, McCloud TG, Hembree JA, Byrn SR, Chang CJ. Revised structure of podolactone C, the antileukemic component of podocarpus milanjianus rendle Journal of Organic Chemistry. 49: 942-945.  1
1983 Chang CJ, Gomes JD, Byrn SR. Chemical modification of deoxyribonucleic acids: A direct study by carbon-13 nuclear magnetic resonance spectroscopy Journal of Organic Chemistry. 48: 5151-5160.  1
1983 Shieh TL, Lin CT, McKenzie AT, Byrn SR. Relationship between the solid-state and solution conformations of β-(benzylamino)crotonate Journal of Organic Chemistry. 48: 3103-3105.  1
1982 Clay RJ, Knevel AM, Byrn SR. The desolvation and oxidation of crystals of dialuric acid monohydrate Journal of Pharmaceutical Sciences. 71: 1289-1291. PMID 7175727 DOI: 10.1002/jps.2600711127  1
1982 Shieh TL, Byrn SR. Solution conformation of the thermolysin inhibitors carbobenzoxy-L-phenylalanine and β-phenylpropionyl-L-phenylalanine and comparison of the solution conformation to the enzyme-bound conformation Journal of Medicinal Chemistry. 25: 403-408. PMID 7069718  1
1982 Gibson‐Clay G, Byrn SR, Heinstein P. The interaction of granaticin with nucleic acids and pyruvate decarboxylase Journal of Pharmaceutical Sciences. 71: 467-468. PMID 6177848 DOI: 10.1002/jps.2600710427  1
1982 Perrier PR, Byrn SR. Dehydration of glucuronamide hydrate. Confirmation of the predicted influence of crystal packing on dehydration reactions Journal of Organic Chemistry. 47: 4677-4680.  1
1982 Perrier PR, Byrn SR. Influence of crystal packing on the solid-state desolvation of purine and pyrimidine hydrates: Loss of water of crystallization from thymine monohydrate, cytosine monohydrate, 5-nitrouracil monohydrate, and 2′-deoxyadenosine monohydrate Journal of Organic Chemistry. 47: 4671-4676.  1
1982 Lin CT, Perrier P, Clay GG, Sutton PA, Byrn SR. Solid-state photooxidation of 21-cortisol tert-butylacetate to 21-cortisone tert-butylacetate Journal of Organic Chemistry. 47: 2978-2981.  1
1981 Migliaccio GP, Byrn SR. Comparisons of rotamer populations of nialamide, azaperone, and chloroquine in solid state and in solution Journal of Pharmaceutical Sciences. 70: 284-287. PMID 7264892 DOI: 10.1002/jps.2600700315  1
1981 Byrn SR, Siew PY. Crystal structure and solid‐state behavior of aspirin anhydride crystals Journal of Pharmaceutical Sciences. 70: 280-283. PMID 7264891 DOI: 10.1002/jps.2600700314  1
1981 Migliaccio GP, Shieh TL, Byrn SR, Hathaway BA, Nichols DE. Comparison of solution conformational preferences for the hallucinogens bufotenin and psilocin using 360-MHz proton NMR spectroscopy. Journal of Medicinal Chemistry. 24: 206-9. PMID 6259355  1
1981 Chang CJ, Gomes JD, Byrn SR. Chemical modification of deoxyribonucleic acids: A direct study by NMR spectroscopy Journal of the American Chemical Society. 103: 2892-2894.  1
1980 Pyne SG, Hensel MJ, Byrn SR, McKenzie AT, Fuchs PL. Cytochalasin support studies. Chiral and stereochemical control via an intramolecular Diels-Alder reaction of a (Z)-diene [37] Journal of the American Chemical Society. 102: 5960-5962.  1
1979 Lin CT, Byrn SR. Solid gas reaction of hydrazobenzene with methyl iodide Tetrahedron Letters. 20: 4623-4626. DOI: 10.1016/S0040-4039(01)86666-1  1
1978 Cassady JM, Byrn SR, Stamos IK, Evans SM, McKenzie A. Potential antitumor agents. Synthesis, reactivity, and cytotoxicity of α-methylene carbonyl compounds Journal of Medicinal Chemistry. 21: 815-819. PMID 691007  1
1978 Tsai MD, Byrn SR, Chang C, Floss HG, Weintraub HJ. Conformational analysis of pyridoxal Schiff's bases. Nuclear magnetic resonance studies of the conformations about the C4-C4', Calpha-Cbeta, and N-Calpha bonds of the pyridoxal Schiff's bases of amino acids. Biochemistry. 17: 3177-82. PMID 687573  1
1978 Byrn SR, Dolch GD. Analysis of binding of daunorubicin and doxorubicin to DNA using computerized curve‐fitting procedures Journal of Pharmaceutical Sciences. 67: 688-693. PMID 641812 DOI: 10.1002/jps.2600670532  1
1978 Lin CT, Siew PY, Byrn SR. Solid-state dehydrochlorination and decarboxylation reactions. Part 2.l reactions of three crystal habits of p-aminosalicylic acid hydrochloride and the crystal structure of p-aminosalicylic acid hydrochloride Journal of the Chemical Society, Perkin Transactions 2. 963-968. DOI: 10.1039/P29780000963  1
1978 Lin CT, Siew PY, Byrn SR. Solid-state dehydrochlorination and decarboxylation reactions. Part 1. reactions of p-aminosalicylic acid hydrochloride and p-aminosalicylic acid, and revised crystal structure of p-aminosalicylic acid Journal of the Chemical Society, Perkin Transactions 2. 957-962. DOI: 10.1039/P29780000957  1
1978 Lin CT, Byrn SR. Solvolysis of hydrazobenzene in methyl iodide Tetrahedron Letters. 19: 1975-1978. DOI: 10.1016/S0040-4039(01)94725-2  1
1978 Lin CT, Byrn SR. DESOLVATIONS OF SOLVATED ORGANIC CRYSTALS Mol Cryst Liq Cryst. 50: 99-104.  1
1977 Byrn SR, Siew PY. Structure and conformation of β-thiodan in the solid state and in solution. Application of the infrared-X-ray method Journal of the Chemical Society, Perkin Transactions 2. 144-149. DOI: 10.1039/P29770000144  1
1977 Stamos IK, Howie GA, Manni PE, Haws WJ, Byrn SR, Cassady JM. Synthesis and structures of dilactones related to anemonin Journal of Organic Chemistry. 42: 1703-1709.  1
1976 Byrn SR, Graber CW, Midland SL. Comparison of the solid and solution conformations of methapyriline, tripelennamine, diphenhydramine, histamine, and choline. The infrared-X-ray method for determination of solution conformations Journal of Organic Chemistry. 41: 2283-2288. PMID 932856  1
1976 Byrn SR, Lin CT. The effect of crystal packing and defects on desolvation of hydrate crystals of caffeine and L-(-)-1,4-cyclohexadiene-1-alanine [8] Journal of the American Chemical Society. 98: 4004-4005. PMID 932354  1
1976 Byrn SR. Mechanisms of solid‐state reactions of drugs Journal of Pharmaceutical Sciences. 65: 1-22. PMID 768447 DOI: 10.1002/jps.2600650102  1
1974 Byrn SR. The cation-binding properties of gramioidin Biochemistry. 13: 5186-5193. PMID 4139970  1
1972 Byrn SR, Curtin DY, Paul IC. The X-ray crystal structures of the yellow and white forms of dimethyl 3,6-dichloro-2,5-dihydroxyterephthalate and a study of the conversion of the yellow form to the white form in the solid state Journal of the American Chemical Society. 94: 890-898.  1
1972 Wang AHJ, Missavage RJ, Byrn SR, Paul IC. Crystal and molecular structure of 1-azabicyclo[3.3.3]undecane hydrochloride. Correlation of some molecular dimensions with spectroscopic properties Journal of the American Chemical Society. 94: 7100-7104.  1
1971 Byrn SR, Maverick E, Muscio OJ, Trueblood KN, Jacobs TL. The structures of two head-to-head allene dimers [7] Journal of the American Chemical Society. 93: 6680-6682.  1
1969 Curtin DY, Byrn SR. Stereoisomerism at the oxygen-carbon single bond due to hydrogen bonding. Structures of the yellow and white crystalline forms of dimethyl 3,6-dichloro-2,5-dihydroxyterephthalate [15] Journal of the American Chemical Society. 91: 1865-1866.  1
1969 Curtin DY, Byrn SR. Structures in solution of the yellow and white forms of dimethyl 3,6-dichloro-2,5-dihydroxyterephthalate Journal of the American Chemical Society. 91: 6102-6106.  1
1969 Curtin DY, Byrn SR, Pendergrass DB. Thermal rearrangement of arylazotribenzoylmethanes in the solid state. Examination with differential thermal analysis Journal of Organic Chemistry. 34: 3345-3349.  1
1967 Weingarten H, Miles MG, Byrn SR, Hobbs CF. Amination of β-dicarbonyl compounds with tetrakis(dimethylamino)titanium [20] Journal of the American Chemical Society. 89: 5974.  1
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