Cornelis G. Kruse - Publications

Affiliations: 
Solvay Pharmaceuticals, Weesp 
Area:
drug discovery
Website:
http://www.knaw.nl/Pages/DEF/27/927.bGFuZz1OTA.html

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 den Boon FS, Werkman TR, Schaafsma-Zhao Q, Houthuijs K, Vitalis T, Kruse CG, Wadman WJ, Chameau P. Activation of type-1 cannabinoid receptor shifts the balance between excitation and inhibition towards excitation in layer II/III pyramidal neurons of the rat prelimbic cortex. PflüGers Archiv : European Journal of Physiology. 467: 1551-64. PMID 25081244 DOI: 10.1007/S00424-014-1586-Z  0.88
2014 Hines CS, Ray K, Schmidt JJ, Xiong F, Feenstra RW, Pras-Raves M, de Moes JP, Lange JH, Melikishvili M, Fried MG, Mortenson P, Charlton M, Patel Y, Courtney SM, Kruse CG, et al. Allosteric inhibition of the neuropeptidase neurolysin. The Journal of Biological Chemistry. 289: 35605-19. PMID 25378390 DOI: 10.1074/Jbc.M114.620930  0.88
2014 den Boon FS, Chameau P, Houthuijs K, Bolijn S, Mastrangelo N, Kruse CG, Maccarrone M, Wadman WJ, Werkman TR. Endocannabinoids produced upon action potential firing evoke a Cl(-) current via type-2 cannabinoid receptors in the medial prefrontal cortex. PflüGers Archiv : European Journal of Physiology. 466: 2257-68. PMID 24671573 DOI: 10.1007/S00424-014-1502-6  0.88
2013 de Bruin NM, McCreary AC, van Loevezijn A, de Vries TJ, Venhorst J, van Drimmelen M, Kruse CG. A novel highly selective 5-HT6 receptor antagonist attenuates ethanol and nicotine seeking but does not affect inhibitory response control in Wistar rats. Behavioural Brain Research. 236: 157-65. PMID 22974550 DOI: 10.1016/J.Bbr.2012.08.048  0.88
2013 Weinberg K, Stoit A, Kruse CG, Haddow MF, Gallagher T. Synthesis and differential functionalisation of pyrrolidine and piperidine based spirodiamine scaffolds Tetrahedron. 69: 4694-4707. DOI: 10.1016/j.tet.2013.03.064  0.88
2012 den Boon FS, Chameau P, Schaafsma-Zhao Q, van Aken W, Bari M, Oddi S, Kruse CG, Maccarrone M, Wadman WJ, Werkman TR. Excitability of prefrontal cortical pyramidal neurons is modulated by activation of intracellular type-2 cannabinoid receptors. Proceedings of the National Academy of Sciences of the United States of America. 109: 3534-9. PMID 22331871 DOI: 10.1073/Pnas.1118167109  0.88
2012 Núñez S, Venhorst J, Kruse CG. Target-drug interactions: first principles and their application to drug discovery. Drug Discovery Today. 17: 10-22. PMID 21777691 DOI: 10.1016/j.drudis.2011.06.013  0.88
2011 Blaazer AR, Lange JH, van der Neut MA, Mulder A, den Boon FS, Werkman TR, Kruse CG, Wadman WJ. Novel indole and azaindole (pyrrolopyridine) cannabinoid (CB) receptor agonists: design, synthesis, structure-activity relationships, physicochemical properties and biological activity. European Journal of Medicinal Chemistry. 46: 5086-98. PMID 21885167 DOI: 10.1016/J.Ejmech.2011.08.021  0.88
2011 Lange JH, Venhorst J, van Dongen MJ, Frankena J, Bassissi F, de Bruin NM, den Besten C, de Beer SB, Oostenbrink C, Markova N, Kruse CG. Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. European Journal of Medicinal Chemistry. 46: 4808-19. PMID 21880399 DOI: 10.1016/j.ejmech.2011.04.023  0.88
2011 van Loevezijn A, Venhorst J, Iwema Bakker WI, de Korte CG, de Looff W, Verhoog S, van Wees JW, van Hoeve M, van de Woestijne RP, van der Neut MA, Borst AJ, van Dongen MJ, de Bruin NM, Keizer HG, Kruse CG. N'-(arylsulfonyl)pyrazoline-1-carboxamidines as novel, neutral 5-hydroxytryptamine 6 receptor (5-HT₆R) antagonists with unique structural features. Journal of Medicinal Chemistry. 54: 7030-54. PMID 21866910 DOI: 10.1021/jm200466r  0.88
2011 de Bruin NM, Prickaerts J, van Loevezijn A, Venhorst J, de Groote L, Houba P, Reneerkens O, Akkerman S, Kruse CG. Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats. Neurobiology of Learning and Memory. 96: 392-402. PMID 21757018 DOI: 10.1016/J.Nlm.2011.06.015  0.88
2011 Werkman TR, McCreary AC, Kruse CG, Wadman WJ. NK3 receptors mediate an increase in firing rate of midbrain dopamine neurons of the rat and the guinea pig. Synapse (New York, N.Y.). 65: 814-26. PMID 21218451 DOI: 10.1002/Syn.20908  0.88
2011 de Bruin NM, Lange JH, Kruse CG, Herremans AH, Schoffelmeer AN, van Drimmelen M, De Vries TJ. SLV330, a cannabinoid CB(1) receptor antagonist, attenuates ethanol and nicotine seeking and improves inhibitory response control in rats. Behavioural Brain Research. 217: 408-15. PMID 21074574 DOI: 10.1016/J.Bbr.2010.11.013  0.88
2011 Lange JHM, Verhoog S, Sanders HJ, Van Loevezijn A, Kruse CG. A novel atom-efficient, one-pot synthesis of sulfonylguanidines and sulfamoylguanidines Tetrahedron Letters. 52: 3198-3200. DOI: 10.1016/j.tetlet.2011.04.031  0.88
2010 Venhorst J, Núñez S, Kruse CG. Design of a high fragment efficiency library by molecular graph theory. Acs Medicinal Chemistry Letters. 1: 499-503. PMID 24900238 DOI: 10.1021/ml100163s  0.88
2010 Lange JH, van der Neut MA, Borst AJ, Yildirim M, van Stuivenberg HH, van Vliet BJ, Kruse CG. Probing the cannabinoid CB1/CB2 receptor subtype selectivity limits of 1,2-diarylimidazole-4-carboxamides by fine-tuning their 5-substitution pattern. Bioorganic & Medicinal Chemistry Letters. 20: 2770-5. PMID 20363132 DOI: 10.1016/j.bmcl.2010.03.068  0.88
2010 Núñez S, Venhorst J, Kruse CG. Assessment of a novel scoring method based on solvent accessible surface area descriptors. Journal of Chemical Information and Modeling. 50: 480-6. PMID 20356089 DOI: 10.1021/ci9004628  0.88
2010 Yan Y, Zhou P, Rotella DP, Feenstra R, Kruse CG, Reinders JH, van der Neut M, Lai M, Zhang J, Kowal DM, Carrick T, Marquis KL, Pausch MH, Robichaud AJ. Potent dihydroquinolinone dopamine D2 partial agonist/serotonin reuptake inhibitors for the treatment of schizophrenia. Bioorganic & Medicinal Chemistry Letters. 20: 2983-6. PMID 20347298 DOI: 10.1016/j.bmcl.2010.02.105  0.88
2010 Lange JH, van der Neut MA, den Hartog AP, Wals HC, Hoogendoorn J, van Stuivenberg HH, van Vliet BJ, Kruse CG. Synthesis, SAR and intramolecular hydrogen bonding pattern of 1,3,5-trisubstituted 4,5-dihydropyrazoles as potent cannabinoid CB(1) receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 1752-7. PMID 20137935 DOI: 10.1016/j.bmcl.2010.01.049  0.88
2010 de Bruin NM, Prickaerts J, Lange JH, Akkerman S, Andriambeloson E, de Haan M, Wijnen J, van Drimmelen M, Hissink E, Heijink L, Kruse CG. SLV330, a cannabinoid CB1 receptor antagonist, ameliorates deficits in the T-maze, object recognition and Social Recognition Tasks in rodents. Neurobiology of Learning and Memory. 93: 522-31. PMID 20132903 DOI: 10.1016/J.Nlm.2010.01.010  0.88
2010 Lange JH, Coolen HK, van der Neut MA, Borst AJ, Stork B, Verveer PC, Kruse CG. Design, synthesis, biological properties, and molecular modeling investigations of novel tacrine derivatives with a combination of acetylcholinesterase inhibition and cannabinoid CB1 receptor antagonism. Journal of Medicinal Chemistry. 53: 1338-46. PMID 20047331 DOI: 10.1021/jm901614b  0.88
2010 Brennan JA, Graf R, Grauer SM, Navarra RL, Pulicicchio CM, Hughes ZA, Lin Q, Wantuch C, Rosenzweig-Lipson S, Pruthi F, Lai M, Smith D, Goutier W, van de Neut M, Robichaud AJ, ... ... Kruse C, et al. WS-50030 [7-{4-[3-(1H-inden-3-yl)propyl]piperazin-1-yl}-1,3-benzoxazol-2(3H)-one]: a novel dopamine D2 receptor partial agonist/serotonin reuptake inhibitor with preclinical antipsychotic-like and antidepressant-like activity. The Journal of Pharmacology and Experimental Therapeutics. 332: 190-201. PMID 19828876 DOI: 10.1124/jpet.109.157388  0.88
2009 Rotella DP, McFarlane GR, Greenfield A, Grosanu C, Robichaud AJ, Denny RA, Feenstra RW, Núñez-García S, Reinders JH, Neut Mv, McCreary A, Kruse CG, Sullivan K, Pruthi F, Lai M, et al. Tetrahydrocarbazole-based serotonin reuptake inhibitor/dopamine D2 partial agonists for the potential treatment of schizophrenia. Bioorganic & Medicinal Chemistry Letters. 19: 5552-5. PMID 19720528 DOI: 10.1016/j.bmcl.2009.08.050  0.88
2009 Lange JH, den Hartog AP, van der Neut MA, van Vliet BJ, Kruse CG. Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1 receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 19: 5675-8. PMID 19699640 DOI: 10.1016/j.bmcl.2009.08.007  0.88
2008 Blaazer AR, Smid P, Kruse CG. Structure-activity relationships of phenylalkylamines as agonist ligands for 5-HT(2A) receptors. Chemmedchem. 3: 1299-309. PMID 18666267 DOI: 10.1002/cmdc.200800133  0.88
2008 Lange JH, Kruse CG. Cannabinoid CB1 receptor antagonists in therapeutic and structural perspectives. Chemical Record (New York, N.Y.). 8: 156-68. PMID 18563799 DOI: 10.1002/tcr.20147  0.88
2008 Venhorst J, Núñez S, Terpstra JW, Kruse CG. Assessment of scaffold hopping efficiency by use of molecular interaction fingerprints. Journal of Medicinal Chemistry. 51: 3222-9. PMID 18447336 DOI: 10.1021/jm8001058  0.88
2008 Stoit AR, den Hartog AP, Mons H, van Schaik S, Barkhuijsen N, Stroomer C, Coolen HK, Reinders JH, Adolfs TJ, van der Neut M, Keizer H, Kruse CG. 7-Azaindole derivatives as potential partial nicotinic agonists. Bioorganic & Medicinal Chemistry Letters. 18: 188-93. PMID 18006307 DOI: 10.1016/j.bmcl.2007.10.101  0.88
2007 Lange JH, Reinders JH, Tolboom JT, Glennon JC, Coolen HK, Kruse CG. Principal component analysis differentiates the receptor binding profiles of three antipsychotic drug candidates from current antipsychotic drugs. Journal of Medicinal Chemistry. 50: 5103-8. PMID 17880057 DOI: 10.1021/jm070516u  0.88
2007 Bouwmeester H, Gerrits MA, Roozemond JG, Snapper J, Ronken E, Kruse CG, Westenberg HG, van Ree JM. Neonatal basolateral amygdala lesions affect monoamine and cannabinoid brain systems in adult rats. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 10: 727-39. PMID 17076936 DOI: 10.1017/S1461145706007346  0.88
2007 McCreary AC, Glennon JC, Ashby CR, Meltzer HY, Li Z, Reinders JH, Hesselink MB, Long SK, Herremans AH, van Stuivenberg H, Feenstra RW, Kruse CG. SLV313 (1-(2,3-dihydro-benzo[1,4]dioxin-5-yl)-4- [5-(4-fluoro-phenyl)-pyridin-3-ylmethyl]-piperazine monohydrochloride): a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 78-94. PMID 16710314 DOI: 10.1038/Sj.Npp.1301098  0.88
2006 Olijslagers JE, Werkman TR, McCreary AC, Kruse CG, Wadman WJ. Modulation of midbrain dopamine neurotransmission by serotonin, a versatile interaction between neurotransmitters and significance for antipsychotic drug action. Current Neuropharmacology. 4: 59-68. PMID 18615139 DOI: 10.2174/157015906775203020  0.88
2006 Feenstra RW, van den Hoogenband A, Stroomer CN, van Stuivenberg HH, Tulp MT, Long SK, van der Heyden JA, Kruse CG. SAR study of 1-aryl-4-(phenylarylmethyl)piperazines as ligands for both dopamine D2 and serotonin 5-HT1A receptors showing varying degrees of (Ant)agonism. Selection of a potential atypical antipsychotic. Chemical & Pharmaceutical Bulletin. 54: 1326-30. PMID 16946546 DOI: 10.1248/Cpb.54.1326  0.88
2006 Gelens E, De Kanter FJ, Schmitz RF, Sliedregt LA, Van Steen BJ, Kruse CG, Leurs R, Groen MB, Orru RV. Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation. Molecular Diversity. 10: 17-22. PMID 16404525 DOI: 10.1007/S11030-006-8695-3  0.88
2006 Kuster GJ, van Berkom LW, Kalmoua M, van Loevezijn A, Sliedregt LA, van Steen BJ, Kruse CG, Rutjes FP, Scheeren HW. Synthesis of spirohydantoins and spiro-2,5-diketopiperazines via resin-bound cyclic alpha,alpha-disubstituted alpha-amino esters. Journal of Combinatorial Chemistry. 8: 85-94. PMID 16398558 DOI: 10.1021/cc050072s  0.88
2005 Smid P, Coolen HK, Keizer HG, van Hes R, de Moes JP, den Hartog AP, Stork B, Plekkenpol RH, Niemann LC, Stroomer CN, Tulp MT, van Stuivenberg HH, McCreary AC, Hesselink MB, Herremans AH, ... Kruse CG, et al. Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition. Journal of Medicinal Chemistry. 48: 6855-69. PMID 16250644 DOI: 10.1021/jm050148z  0.88
2005 Olijslagers JE, Perlstein B, Werkman TR, McCreary AC, Siarey R, Kruse CG, Wadman WJ. The role of 5-HT(2A) receptor antagonism in amphetamine-induced inhibition of A10 dopamine neurons in vitro. European Journal of Pharmacology. 520: 77-85. PMID 16154561 DOI: 10.1016/J.Ejphar.2005.08.014  0.88
2005 Lange JH, van Stuivenberg HH, Veerman W, Wals HC, Stork B, Coolen HK, McCreary AC, Adolfs TJ, Kruse CG. Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity. Bioorganic & Medicinal Chemistry Letters. 15: 4794-8. PMID 16140010 DOI: 10.1016/j.bmcl.2005.07.054  0.88
2005 Lange JH, Kruse CG. Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists. Drug Discovery Today. 10: 693-702. PMID 15896682 DOI: 10.1016/S1359-6446(05)03427-6  0.88
2005 Lange JH, van Stuivenberg HH, Coolen HK, Adolfs TJ, McCreary AC, Keizer HG, Wals HC, Veerman W, Borst AJ, de Looff W, Verveer PC, Kruse CG. Bioisosteric replacements of the pyrazole moiety of rimonabant: synthesis, biological properties, and molecular modeling investigations of thiazoles, triazoles, and imidazoles as potent and selective CB1 cannabinoid receptor antagonists. Journal of Medicinal Chemistry. 48: 1823-38. PMID 15771428 DOI: 10.1021/jm040843r  0.88
2005 Gelens E, Smeets L, Sliedregt LAJM, Van Steen BJ, Kruse CG, Leurs R, Orru RVA. An atom efficient and solvent-free synthesis of structurally diverse amides using microwaves Tetrahedron Letters. 46: 3751-3754. DOI: 10.1016/J.Tetlet.2005.03.146  0.88
2004 Werkman TR, Olijslagers JE, Perlstein B, Jansen AH, McCreary AC, Kruse CG, Wadman WJ. Quetiapine increases the firing rate of rat substantia nigra and ventral tegmental area dopamine neurons in vitro. European Journal of Pharmacology. 506: 47-53. PMID 15588623 DOI: 10.1016/J.Ejphar.2004.10.053  0.88
2004 Lange JH, Kruse CG. Recent advances in CB1 cannabinoid receptor antagonists. Current Opinion in Drug Discovery & Development. 7: 498-506. PMID 15338959  0.88
2004 Olijslagers JE, Werkman TR, McCreary AC, Siarey R, Kruse CG, Wadman WJ. 5-HT2 receptors differentially modulate dopamine-mediated auto-inhibition in A9 and A10 midbrain areas of the rat. Neuropharmacology. 46: 504-10. PMID 14975674 DOI: 10.1016/J.Neuropharm.2003.10.003  0.88
2004 Lange JH, Coolen HK, van Stuivenberg HH, Dijksman JA, Herremans AH, Ronken E, Keizer HG, Tipker K, McCreary AC, Veerman W, Wals HC, Stork B, Verveer PC, den Hartog AP, de Jong NM, ... ... Kruse CG, et al. Synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective CB(1) cannabinoid receptor antagonists. Journal of Medicinal Chemistry. 47: 627-43. PMID 14736243 DOI: 10.1021/jm031019q  0.88
2003 Pijlman FT, Herremans AH, van de Kieft J, Kruse CG, van Ree JM. Behavioural changes after different stress paradigms: prepulse inhibition increased after physical, but not emotional stress. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 13: 369-80. PMID 12957336 DOI: 10.1016/S0924-977X(03)00040-3  0.88
2003 Daenen EW, Wolterink G, Van Der Heyden JA, Kruse CG, Van Ree JM. Neonatal lesions in the amygdala or ventral hippocampus disrupt prepulse inhibition of the acoustic startle response; implications for an animal model of neurodevelopmental disorders like schizophrenia. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 13: 187-97. PMID 12729945 DOI: 10.1016/S0924-977X(03)00007-5  0.88
2003 Bouwmeester H, Snapper J, Ronken E, Kruse CG, van Ree JM. Effects of neonatal amygdala lesions on [125I] neurotensin binding in specific brain areas of adult rat. The European Journal of Neuroscience. 17: 1319-22. PMID 12670322 DOI: 10.1046/j.1460-9568.2003.02606.x  0.88
2003 van Hes R, Smid P, Stroomer CN, Tipker K, Tulp MT, van der Heyden JA, McCreary AC, Hesselink MB, Kruse CG. SLV310, a novel, potential antipsychotic, combining potent dopamine D2 receptor antagonism with serotonin reuptake inhibition. Bioorganic & Medicinal Chemistry Letters. 13: 405-8. PMID 12565939 DOI: 10.1016/S0960-894X(02)00996-4  0.88
2002 Stoit AR, Lange JH, Hartog AP, Ronken E, Tipker K, Stuivenberg HH, Dijksman JA, Wals HC, Kruse CG. Design, synthesis and biological activity of rigid cannabinoid CB1 receptor antagonists. Chemical & Pharmaceutical Bulletin. 50: 1109-13. PMID 12192147 DOI: 10.1002/chin.200303100  0.88
2002 Lange JHM, Hofmeyer LJF, Hout FAS, Osnabrug SJM, Verveer PC, Kruse CG, Feenstra RW. Microwave-enhanced Goldberg reaction: A novel route to N-arylpiperazinones and N-arylpiperazinediones Tetrahedron Letters. 43: 1101-1104. DOI: 10.1016/S0040-4039(01)02334-6  0.88
2002 Veerman JJN, Klein J, Aben RWM, Scheeren HW, Kruse CG, Van Maarseveen JH, Rutjes FPJT, Hiemstra H. Solid-phase synthesis of piperidines by N-acyliminium ion chemistry European Journal of Organic Chemistry. 3133-3139.  0.88
2001 Daenen EW, Van der Heyden JA, Kruse CG, Wolterink G, Van Ree JM. Adaptation and habituation to an open field and responses to various stressful events in animals with neonatal lesions in the amygdala or ventral hippocampus. Brain Research. 918: 153-65. PMID 11684053 DOI: 10.1016/S0006-8993(01)02987-0  0.88
2001 Feenstra RW, de Moes J, Hofma JJ, Kling H, Kuipers W, Long SK, Tulp MT, van der Heyden JA, Kruse CG. New 1-aryl-4-(biarylmethylene)piperazines as potential atypical antipsychotics sharing dopamine D(2)-receptor and serotonin 5-HT(1A)-receptor affinities. Bioorganic & Medicinal Chemistry Letters. 11: 2345-9. PMID 11527728 DOI: 10.1016/S0960-894X(01)00425-5  0.88
2001 Werkman TR, Kruse CG, Nievelstein H, Long SK, Wadman WJ. In vitro modulation of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area by antipsychotic drugs. Neuropharmacology. 40: 927-36. PMID 11378163 DOI: 10.1016/S0028-3908(01)00015-6  0.88
2001 Wolterink G, Daenen LE, Dubbeldam S, Gerrits MA, van Rijn R, Kruse CG, Van Der Heijden JA, Van Ree JM. Early amygdala damage in the rat as a model for neurodevelopmental psychopathological disorders. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 11: 51-9. PMID 11226812 DOI: 10.1016/S0924-977X(00)00138-3  0.88
2001 Westerink BH, Kawahara Y, De Boer P, Geels C, De Vries JB, Wikström HV, Van Kalkeren A, Van Vliet B, Kruse CG, Long SK. Antipsychotic drugs classified by their effects on the release of dopamine and noradrenaline in the prefrontal cortex and striatum. European Journal of Pharmacology. 412: 127-38. PMID 11165224 DOI: 10.1016/S0014-2999(00)00935-3  0.88
2001 Van Maarseveen JH, Meester WJN, Veerman JJN, Kruse CG, Hermkens PHH, Rutjes FPJT, Hiemstra H. Development and application of allyl, 2-sulfonylethyl and 2-thioethyl carbamate linkers for solid phase N-acyliminium ion chemistry Journal of the Chemical Society. Perkin Transactions 1. 994-1001. DOI: 10.1039/B100998M  0.88
2000 Werkman TR, Kruse CG, Nievelstein H, Long SK, Wadman WJ. Neurotensin attenuates the quinpirole-induced inhibition of the firing rate of dopamine neurons in the rat substantia nigra pars compacta and the ventral tegmental area. Neuroscience. 95: 417-23. PMID 10658621 DOI: 10.1016/S0306-4522(99)00449-2  0.88
1999 Lange JH, de Jong JC, Sanders HJ, Visser GM, Kruse CG. A straightforward synthetic approach for roxindole. Bioorganic & Medicinal Chemistry Letters. 9: 1055-6. PMID 10230639 DOI: 10.1016/S0960-894X(99)00135-3  0.88
1998 Seerden JP, Tulp MT, Scheeren HW, Kruse CG. Synthesis and structure-activity data of some new epibatidine analogues. Bioorganic & Medicinal Chemistry. 6: 2103-10. PMID 9881100 DOI: 10.1016/S0968-0896(98)00163-1  0.88
1998 van Maarseveen JH, den Hartog JA, Tipker K, Reinders JH, Brakkee J, Schön U, Kehrbach W, Kruse CG. Design and synthesis of an orally active GPIIb/IIIa antagonist based on a phenylpiperazine scaffold. Bioorganic & Medicinal Chemistry Letters. 8: 1531-6. PMID 9873384 DOI: 10.1016/S0960-894X(98)00257-1  0.88
1998 Westerink BH, de Boer P, de Vries JB, Kruse CG, Long SK. Antipsychotic drugs induce similar effects on the release of dopamine and noradrenaline in the medial prefrontal cortex of the rat brain. European Journal of Pharmacology. 361: 27-33. PMID 9851538 DOI: 10.1016/S0014-2999(98)00711-0  0.88
1998 Chamoin S, Houldsworth S, Kruse CG, Bakker WI, Snieckus V. The Suzuki-Miyaura cross coupling reactions on solid support. Link to solution phase directed ortho metalation. The Leznoff acetal linker approach to biaryl and heterobiaryl aldehydes Tetrahedron Letters. 39: 4179-4182. DOI: 10.1016/S0040-4039(98)00779-5  0.88
1998 Veerman JJN, Van Maarseveen JH, Visser GM, Kruse CG, Schoemaker HE, Hiemstra H, Rutjes FPJT. Ring-closing metathesis on solid support: Elaboration of a cyclization/cleavage strategy towards unsaturated α-ester-substituted N-heterocycles European Journal of Organic Chemistry. 2583-2589.  0.88
1997 van Maarseveen JH, Scheeren HW, De Clercq E, Balzarini J, Kruse CG. Antiviral and tumor cell antiproliferative SAR studies on tetracyclic eudistomins. II. Bioorganic & Medicinal Chemistry. 5: 955-70. PMID 9208105 DOI: 10.1016/S0968-0896(97)00034-5  0.88
1997 Kuipers W, Kruse CG, van Wijngaarden I, Standaar PJ, Tulp MT, Veldman N, Spek AL, IJzerman AP. 5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines. Journal of Medicinal Chemistry. 40: 300-12. PMID 9022796 DOI: 10.1021/Jm960496O  0.88
1996 Warmerdam EGJC, Van Den Nieuwendijk AMCH, Brussee J, Kruse CG, Van Der Gen A. Asymmetric epoxidation of chiral allylic alcohols Tetrahedron Asymmetry. 7: 2539-2550. DOI: 10.1016/0957-4166(96)00327-8  0.88
1996 Warmerdam EGJC, Van Rijn RD, Brussee J, Kruse CG, Van Der Gen A. Synthesis of α-hydroxy-β-amino acids from chiral cyanohydrins Tetrahedron Asymmetry. 7: 1723-1732. DOI: 10.1016/0957-4166(96)00206-6  0.88
1996 Van Maarseveen JH, Den Hartog JAJ, Engelen V, Finner E, Visser G, Kruse CG. Solid phase ring-closing metathesis: Cyclization/cleavage approach towards a seven membered cycloolefin Tetrahedron Letters. 37: 8249-8252. DOI: 10.1016/0040-4039(96)01881-3  0.88
1996 Warmerdam EGJC, Van Den Nieuwendijk AMCH, Kruse CG, Brussee J, Van Der Gen A. Synthesis of (R)- and (S)-2-hydroxy-3-enoic acid esters Recueil Des Travaux Chimiques Des Pays-Bas-Journal of the Royal Netherlands. 115: 20-24. DOI: 10.1002/Recl.19961150105  0.88
1995 Kuipers W, van Wijngaarden I, Kruse CG, ter Horst-van Amstel M, Tulp MT, IJzerman AP. N4-unsubstituted N1-arylpiperazines as high-affinity 5-HT1A receptor ligands. Journal of Medicinal Chemistry. 38: 1942-54. PMID 7783126 DOI: 10.1021/jm00011a014  0.88
1995 Loos WT, Geluk HW, Ruijken MMA, Kruse CG, Brussee J, Van Der Gen A. Synthesis of optically active cyanohydrins using r-oxynitrilase in a liquid-liquid biphasic system: Part 1: An industrially useful procedure Biocatalysis and Biotransformation. 12: 255-266. DOI: 10.3109/10242429509003188  0.88
1995 van Maarseveen JH, Mulders SJE, Aben RM, Kruse CG, Scheeren HW. An approach to canthine derivatives using the intramolecular Pictet-Spengler condensation Tetrahedron. 51: 4841-4852. DOI: 10.1016/0040-4020(95)00169-9  0.88
1995 H. van Maarseveen J, Oberyé EHH, Bolster MB, Scheeren HW, Kruse CG. Transformations of the tetracyclic skeleton of eudistomins by neighboring-group participation in the Mitsunobu reaction Recueil Des Travaux Chimiques Des Pays-Bas. 114: 27-34. DOI: 10.1002/recl.19951140107  0.88
1994 Aben RWM, Keijsers J, Hams B, Kruse CG, Scheeren HW. Synthesis of endo-2-phenyl-7-azabicyclo[2.2.1]heptane via high pressure Diels-Alder reactions of pyrroles Tetrahedron Letters. 35: 1299-1300. DOI: 10.1016/0040-4039(94)88049-2  0.88
1994 Warmerdam EGJC, Brussee J, Van Der Gen A, Kruse CG. Synthesis of (R)- and (S)-5-(hydroxymethyl)-3-isopropyloxazolidin-2-one, intermediates in the preparation of optically active β-blockers Helvetica Chimica Acta. 77: 252-256.  0.88
1993 Warmerdam EGJC, Brussee J, Kruse CG, van der Gen A. Inversion of the configuration of cyanohydrins by a mitsunobu esterification reaction Tetrahedron. 49: 1063-1070. DOI: 10.1080/10426509308037350  0.88
1993 Ten Hoeve W, Kruse CG, Luteyn JM, Thiecke JRG, Wynberg H. Direct substitution of aromatic ethers by lithium amides. A new aromatic amination reaction Journal of Organic Chemistry. 58: 5101-5106. DOI: 10.1021/jo00071a019  0.88
1993 van Maarseveen JH, Scheeren HW, Kruse CG. Intramolecular Pictet-Spengler reaction of Nb-Alkoxytryptamines. 4. A study towards diastereocontrol in the synthesis of tetracyclic eudistomins Tetrahedron. 49: 2325-2344. DOI: 10.1016/S0040-4020(01)80376-8  0.88
1993 Dijkstra GDH, Th.M. Tulp M, Hermkens PHH, van Maarseveen JH, Scheeren HW, Kruse CG. Synthesis and receptor-affinity profile of N-hydroxytryptamine derivatives for serotonin and tryptamine receptors. A molecular-modeling study Recueil Des Travaux Chimiques Des Pays-Bas. 112: 131-136. DOI: 10.1002/recl.19931120210  0.88
1993 De Vries EFJ, Steenwinkel P, Brussee J, Kruse CG, Van Der Gen A. Synthesis of chiral diaza-18-crown-6 derivatives from optically active diethanolamines Journal of Organic Chemistry. 58: 4315-4325.  0.88
1992 Van Maarseveen JH, Hermkens PH, De Clercq E, Balzarini J, Scheeren HW, Kruse CG. Antiviral and antitumor structure-activity relationship studies on tetracyclic eudistomines. Journal of Medicinal Chemistry. 35: 3223-30. PMID 1324318 DOI: 10.1021/Jm00095A019  0.88
1992 Hermkens PHH, Plate R, Kruse CG, Scheeren HW, Ottenheijm HCJ. Stereoselective synthesis of verruculogen TR-2 featuring the mild formation of a dihydro-β-carboline as an intermediate Journal of Organic Chemistry. 57: 3881-3887. DOI: 10.1021/jo00040a030  0.88
1992 Zandbergen P, Brussee J, van der Gen A, Kruse CG. Stereoselective synthesis of β-hydroxy-α-amino acids from chiral cyanohydrins. Tetrahedron: Asymmetry. 3: 769-774. DOI: 10.1016/S0957-4166(00)80518-2  0.88
1992 Zandbergen P, van den Niewendijk AMCH, Brussee J, van der Gen A, Kruse CG. A one-pot reduction-transimition-reduction synthesis of N-substituted β-ethanolamines from cyanohydrins Tetrahedron. 48: 3977-3982. DOI: 10.1016/S0040-4020(01)88477-5  0.88
1990 Hermkens PHH, Maarseveen JHV, Ottenheijm HCJ, Kruse CG, Scheeren HW. Intramolecular Pictet-Spengler reaction of N-alkoxytryptamines. 3. Stereoselective synthesis of (-)-debromoeudistomin L and (-)-O-methyldebromoeudistomin E and their stereoisomers Journal of Organic Chemistry. 55: 3998-4006. DOI: 10.1021/jo00300a011  0.88
1990 Hermkens PHH, Maarseveen JHV, Berens HW, Smits JMM, Kruse CG, Scheeren HW. Intramolecular Pictet-Spengler reaction of N-alkoxytryptophans and tryptamines. 2. Synthesis of corynanthe alkaloid derivatives containing a tetrahydro-1,2-oxazine as the D ring Journal of Organic Chemistry. 55: 2200-2206. DOI: 10.1021/jo00294a041  0.88
1990 Brussee J, van Benthem RATM, Kruse CG, van der Gen A. Magnesium ion mediated stereospecific formation of N-substituted ethanolamines during reductive amination Tetrahedron: Asymmetry. 1: 163-166. DOI: 10.1016/S0957-4166(00)82370-8  0.88
1990 Brussee J, Dofferhoff F, Kruse CG, Van Der Gen A. Synthesis of optically active ethanolamines. Tetrahedron. 46: 1653-1658. DOI: 10.1016/S0040-4020(01)81972-4  0.88
1990 Brussee J, Loos WT, Kruse CG, Van Der Gen A. Synthesis of optically active silyl protected cyanohydrins Tetrahedron. 46: 979-986. DOI: 10.1016/S0040-4020(01)81377-6  0.88
1990 Hermkens PHH, van Maarseveen JH, Cobben PLHM, Ottenheijm HCJ, Kruse CG, Scheerent HW. Syntheses of 1,3-disubstituted N-oxy-β-carbolines by the Pictet-Spengler reactions of N-oxy-tryptophan and -tryptamine derivatives Tetrahedron. 46: 833-846. DOI: 10.1016/S0040-4020(01)81366-1  0.88
1989 Keijsers J, Hams B, Kruse C, Scheeren H. High-pressure Diels-Alder reactions of 1-methoxycarbonyl-3-methylthio- and -3-phenylthiopyrrole. An efficient entry to 7-azabicyclo [2.2.1] heptanes Heterocycles. 29: 79-86. DOI: 10.3987/COM-88-4662  0.88
1989 Hermkens PHH, Jan JH, Kruse CG, Scheeren HW. Intramolecular Pictet-Spengler reaction of N-alkoxy tryptamines I. Synthesis of (±)-Deamino-debromo-Eudistomin L Tetrahedron Letters. 30: 5009-5012. DOI: 10.1016/S0040-4039(01)80568-2  0.88
1988 van Wijngaarden I, Kruse CG, van der Heyden JA, Tulp MT. 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 2. Journal of Medicinal Chemistry. 31: 1934-40. PMID 2902226 DOI: 10.1021/jm00118a011  0.88
1988 Hermkens PHH, Maarseveen JHv, Kruse CG, Scheeren HW. 1,3-Dipolar cycloaddition of nitrones with nitriles. Scope and mechanistic study Tetrahedron. 44: 6491-6504. DOI: 10.1016/S0040-4020(01)89838-0  0.88
1988 Kruse CG, Troost JJ, Cohen-Fernandes P, van der Linden H, van Loon JD. Single-step conversion of aliphatic, aromatic and heteroaromatic primary amines into piperazine-2,6-diones Recueil Des Travaux Chimiques Des Pays-Bas. 107: 303-309. DOI: 10.1002/recl.19881070402  0.88
1988 Van Der Heyden JAM, Kruse CG. Befiperide hydrochloride Drugs of the Future. 13: 939-942.  0.88
1987 van Wijngaarden I, Kruse CG, van Hes R, van der Heyden JA, Tulp MT. 2-Phenylpyrroles as conformationally restricted benzamide analogues. A new class of potential antipsychotics. 1. Journal of Medicinal Chemistry. 30: 2099-104. PMID 2889830 DOI: 10.1021/jm00394a028  0.88
1987 Kruse CG, Bouw JP, van Hes R, van de Kuilen A, den Hartog JAJ. New methods for the synthesis of 2-arylpyrroles Heterocycles. 26: 3141-3151. DOI: 10.3987/R-1987-12-3141  0.88
1979 Kruse CG, De Leeuw HPM, Van Der Gen A. Synthetic applications of cyclic α-chloro-ethers and -thioethers. Part 5. Tetrahydrofuranyluracil derivatives: Conformational properties in solution Journal of the Chemical Society, Perkin Transactions 2. 827-832. DOI: 10.1039/P29790000827  0.76
1979 Kruse CG, Poels EK, Van Der Gen A. Reactions of 2-chlorotetrahydrofuran and 2-chlorotetrahydrothiophene with phosphorus, carbon, and nitrogen nucleophiles Journal of Organic Chemistry. 44: 2911-2915. DOI: 10.1021/Jo01330A018  0.76
1979 Kruse CG, Wijsman A, Van Der Gen A. Synthetic applications of 2-chloro-1,3-dithiane. 2. Reactions with carbon nucleophiles Journal of Organic Chemistry. 44: 1847-1851. DOI: 10.1021/Jo01325A022  0.76
1979 Kruse CG, Janse ACV, Dert V, Van Der Gen A. Decarbethoxylation and ring-opening reactions of 2-tetrahydrofuranyl-, 2-tetrahydrothienyl-, and 2-(1,3-dithianyl)-substituted esters Journal of Organic Chemistry. 44: 2916-2920. DOI: 10.1002/Chin.197950202  0.76
1978 Kruse CG, Poels EK, Jonkers FL, Van Der Gen A. Use of (thio)acetal esters as reagents for the protection of alcohols. Synthesis of 2-tetrahydrothienyl ethers Journal of Organic Chemistry. 43: 3548-3553.  0.76
1977 Kruse CG, Broekhof NLJM, Wijsman A, Van der gen A. Synthetic applications of 2-chloro-1,3-dithiane preparation of ketene dithioacetals Tetrahedron Letters. 18: 885-888. DOI: 10.1016/S0040-4039(01)92782-0  0.76
1976 Kruse CG, Broekhof NLJM, van der Gen A. Protection of hydroxyl- and thiol groups as 2′-0-tetrahydrofuranyl-(THF)-ethers Tetrahedron Letters. 17: 1725-1728. DOI: 10.1016/S0040-4039(00)92935-6  0.76
1973 Janssen JWAM, Koeners HJ, Kruse CG, Habraken CL. Pyrazoles. XII. The preparation of 3(5)-nitropyrazoles by thermal rearrangement of N-nitropyrazoles Journal of Organic Chemistry. 38: 1777-1782.  0.76
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