Titia K. Sixma - Publications

Affiliations: 
Netherlands Cancer Institute 
Area:
Protein crystallography
Website:
http://knaw.nl/nl/leden/leden/4789

112 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mardenborough YSN, Nitsenko K, Laffeber C, Duboc C, Sahin E, Quessada-Vial A, Winterwerp HHK, Sixma TK, Kanaar R, Friedhoff P, Strick TR, Lebbink JHG. The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair. Nucleic Acids Research. PMID 31598722 DOI: 10.1093/nar/gkz834  0.64
2019 Bhairosing-Kok D, Groothuizen FS, Fish A, Dharadhar S, Winterwerp HHK, Sixma TK. Sharp kinking of a coiled-coil in MutS allows DNA binding and release. Nucleic Acids Research. PMID 31372631 DOI: 10.1093/nar/gkz649  0.64
2019 Horn V, Uckelmann M, Zhang H, Eerland J, Aarsman I, le Paige UB, Davidovich C, Sixma TK, van Ingen H. Structural basis of specific H2A K13/K15 ubiquitination by RNF168. Nature Communications. 10: 1751. PMID 30988309 DOI: 10.1038/s41467-019-09756-z  0.36
2019 Dharadhar S, Kim RQ, Uckelmann M, Sixma TK. Quantitative analysis of USP activity in vitro. Methods in Enzymology. 618: 281-319. PMID 30850056 DOI: 10.1016/bs.mie.2018.12.023  0.36
2019 Kim RQ, Geurink PP, Mulder MPC, Fish A, Ekkebus R, El Oualid F, van Dijk WJ, van Dalen D, Ovaa H, van Ingen H, Sixma TK. Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity. Nature Communications. 10: 231. PMID 30651545 DOI: 10.1038/s41467-018-08231-5  0.36
2018 Uckelmann M, Densham RM, Baas R, Winterwerp HHK, Fish A, Sixma TK, Morris JR. USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A. Nature Communications. 9: 229. PMID 29335415 DOI: 10.1038/s41467-017-02653-3  0.64
2017 Uckelmann M, Sixma TK. Histone ubiquitination in the DNA damage response. Dna Repair. PMID 28624371 DOI: 10.1016/j.dnarep.2017.06.011  0.36
2016 Dharadhar S, Clerici M, van Dijk WJ, Fish A, Sixma TK. A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme. Journal of Structural Biology. PMID 27650958 DOI: 10.1016/j.jsb.2016.09.011  0.36
2016 Kim RQ, van Dijk WJ, Sixma TK. Structure of USP7 catalytic domain and three Ubl-domains reveals a connector α-helix with regulatory role. Journal of Structural Biology. PMID 27183903 DOI: 10.1016/j.jsb.2016.05.005  0.36
2016 Speranzini V, Pilotto S, Sixma TK, Mattevi A. Touch, act and go: landing and operating on nucleosomes. The Embo Journal. PMID 26787641 DOI: 10.15252/embj.201593377  1
2016 Sahtoe DD, van Dijk WJ, Ekkebus R, Ovaa H, Sixma TK. BAP1/ASXL1 recruitment and activation for H2A deubiquitination. Nature Communications. 7: 10292. PMID 26739236 DOI: 10.1038/ncomms10292  1
2015 Groothuizen FS, Sixma TK. The conserved molecular machinery in DNA mismatch repair enzyme structures. Dna Repair. PMID 26796427 DOI: 10.1016/j.dnarep.2015.11.012  1
2015 Schelpe J, Monté D, Dewitte F, Sixma TK, Rucktooa P. Structure of UBE2Z provides functional insight into specificity in the FAT10 conjugation machinery. The Journal of Biological Chemistry. PMID 26555268 DOI: 10.1074/jbc.M115.671545  1
2015 Thorslund T, Ripplinger A, Hoffmann S, Wild T, Uckelmann M, Villumsen B, Narita T, Sixma TK, Choudhary C, Bekker-Jensen S, Mailand N. Histone H1 couples initiation and amplification of ubiquitin signalling after DNA damage. Nature. PMID 26503038 DOI: 10.1038/nature15401  1
2015 Groothuizen FS, Winkler I, Cristóvão M, Fish A, Winterwerp HH, Reumer A, Marx AD, Hermans N, Nicholls RA, Murshudov GN, Lebbink JH, Friedhoff P, Sixma TK. MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA. Elife. 4: e06744. PMID 26163658 DOI: 10.7554/eLife.06744  1
2015 Sahtoe DD, Sixma TK. Layers of DUB regulation. Trends in Biochemical Sciences. PMID 26073511 DOI: 10.1016/j.tibs.2015.05.002  1
2015 Uckelmann M, Sixma TK. Make them, break them, and catch them: studying rare ubiquitin chains. Molecular Cell. 58: 1-2. PMID 25839429 DOI: 10.1016/j.molcel.2015.03.024  0.36
2015 Pilotto S, Speranzini V, Tortorici M, Durand D, Fish A, Valente S, Forneris F, Mai A, Sixma TK, Vachette P, Mattevi A. Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation. Proceedings of the National Academy of Sciences of the United States of America. 112: 2752-7. PMID 25730864 DOI: 10.1073/pnas.1419468112  1
2015 Sahtoe DD, van Dijk WJ, El Oualid F, Ekkebus R, Ovaa H, Sixma TK. Mechanism of UCH-L5 activation and inhibition by DEUBAD domains in RPN13 and INO80G. Molecular Cell. 57: 887-900. PMID 25702870 DOI: 10.1016/j.molcel.2014.12.039  1
2014 Clerici M, Luna-Vargas MP, Faesen AC, Sixma TK. The DUSP-Ubl domain of USP4 enhances its catalytic efficiency by promoting ubiquitin exchange. Nature Communications. 5: 5399. PMID 25404403 DOI: 10.1038/ncomms6399  1
2014 Mattiroli F, Sixma TK. Lysine-targeting specificity in ubiquitin and ubiquitin-like modification pathways. Nature Structural & Molecular Biology. 21: 308-16. PMID 24699079 DOI: 10.1038/nsmb.2792  1
2014 Mattiroli F, Uckelmann M, Sahtoe DD, van Dijk WJ, Sixma TK. The nucleosome acidic patch plays a critical role in RNF168-dependent ubiquitination of histone H2A. Nature Communications. 5: 3291. PMID 24518117 DOI: 10.1038/ncomms4291  1
2014 Smit JJ, Sixma TK. RBR E3-ligases at work. Embo Reports. 15: 142-54. PMID 24469331 DOI: 10.1002/embr.201338166  1
2013 Smit JJ, van Dijk WJ, El Atmioui D, Merkx R, Ovaa H, Sixma TK. Target specificity of the E3 ligase LUBAC for ubiquitin and NEMO relies on different minimal requirements. The Journal of Biological Chemistry. 288: 31728-37. PMID 24030825 DOI: 10.1074/jbc.M113.495846  1
2013 Groothuizen FS, Fish A, Petoukhov MV, Reumer A, Manelyte L, Winterwerp HH, Marinus MG, Lebbink JH, Svergun DI, Friedhoff P, Sixma TK. Using stable MutS dimers and tetramers to quantitatively analyze DNA mismatch recognition and sliding clamp formation. Nucleic Acids Research. 41: 8166-81. PMID 23821665 DOI: 10.1093/nar/gkt582  1
2013 Stornaiuolo M, De Kloe GE, Rucktooa P, Fish A, van Elk R, Edink ES, Bertrand D, Smit AB, de Esch IJ, Sixma TK. Assembly of a π-π stack of ligands in the binding site of an acetylcholine-binding protein. Nature Communications. 4: 1875. PMID 23695669 DOI: 10.1038/ncomms2900  1
2013 Sixma TK. Protein engineering: making ubiquitin specific. Nature Chemical Biology. 9: 10-1. PMID 23238680 DOI: 10.1038/nchembio.1143  1
2013 Faesen AC, Sixma TK, Everett RD. Ubiquitin-Specific Protease USP7 Handbook of Proteolytic Enzymes. 2: 2057-2062. DOI: 10.1016/B978-0-12-382219-2.00463-4  1
2012 Hibbert RG, Sixma TK. Intrinsic flexibility of ubiquitin on proliferating cell nuclear antigen (PCNA) in translesion synthesis. The Journal of Biological Chemistry. 287: 39216-23. PMID 22989887 DOI: 10.1074/jbc.M112.389890  1
2012 Mattiroli F, Vissers JH, van Dijk WJ, Ikpa P, Citterio E, Vermeulen W, Marteijn JA, Sixma TK. RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling. Cell. 150: 1182-95. PMID 22980979 DOI: 10.1016/j.cell.2012.08.005  1
2012 Smit JJ, Monteferrario D, Noordermeer SM, van Dijk WJ, van der Reijden BA, Sixma TK. The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension. The Embo Journal. 31: 3833-44. PMID 22863777 DOI: 10.1038/emboj.2012.217  1
2012 Kanga S, Bernard D, Mager-Heckel AM, Erpapazoglou Z, Mattiroli F, Sixma TK, Léon S, Urban-Grimal D, Tarassov I, Haguenauer-Tsapis R. A deubiquitylating complex required for neosynthesis of a yeast mitochondrial ATP synthase subunit. Plos One. 7: e38071. PMID 22723847 DOI: 10.1371/journal.pone.0038071  1
2012 Faesen AC, Luna-Vargas MP, Sixma TK. The role of UBL domains in ubiquitin-specific proteases. Biochemical Society Transactions. 40: 539-45. PMID 22616864 DOI: 10.1042/BST20120004  1
2012 Radner S, Celie PH, Fuchs K, Sieghart W, Sixma TK, Stornaiuolo M. Transient transfection coupled to baculovirus infection for rapid protein expression screening in insect cells. Journal of Structural Biology. 179: 46-55. PMID 22580066 DOI: 10.1016/j.jsb.2012.04.013  1
2012 Rucktooa P, Haseler CA, van Elk R, Smit AB, Gallagher T, Sixma TK. Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein. The Journal of Biological Chemistry. 287: 23283-93. PMID 22553201 DOI: 10.1074/jbc.M112.360347  1
2012 Nacerddine K, Beaudry JB, Ginjala V, Westerman B, Mattiroli F, Song JY, van der Poel H, Ponz OB, Pritchard C, Cornelissen-Steijger P, Zevenhoven J, Tanger E, Sixma TK, Ganesan S, van Lohuizen M. Akt-mediated phosphorylation of Bmi1 modulates its oncogenic potential, E3 ligase activity, and DNA damage repair activity in mouse prostate cancer. The Journal of Clinical Investigation. 122: 1920-32. PMID 22505453 DOI: 10.1172/JCI57477  1
2012 Mallette FA, Mattiroli F, Cui G, Young LC, Hendzel MJ, Mer G, Sixma TK, Richard S. RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites. The Embo Journal. 31: 1865-78. PMID 22373579 DOI: 10.1038/emboj.2012.47  1
2012 Osipov AV, Rucktooa P, Kasheverov IE, Filkin SY, Starkov VG, Andreeva TV, Sixma TK, Bertrand D, Utkin YN, Tsetlin VI. Dimeric α-cobratoxin X-ray structure: localization of intermolecular disulfides and possible mode of binding to nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 287: 6725-34. PMID 22223648 DOI: 10.1074/jbc.M111.322313  1
2011 Faesen AC, Luna-Vargas MP, Geurink PP, Clerici M, Merkx R, van Dijk WJ, Hameed DS, El Oualid F, Ovaa H, Sixma TK. The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types. Chemistry & Biology. 18: 1550-61. PMID 22195557 DOI: 10.1016/j.chembiol.2011.10.017  1
2011 Faesen AC, Dirac AM, Shanmugham A, Ovaa H, Perrakis A, Sixma TK. Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase. Molecular Cell. 44: 147-59. PMID 21981925 DOI: 10.1016/j.molcel.2011.06.034  1
2011 Akdemir A, Rucktooa P, Jongejan A, Elk Rv, Bertrand S, Sixma TK, Bertrand D, Smit AB, Leurs R, de Graaf C, de Esch IJ. Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors. Bioorganic & Medicinal Chemistry. 19: 6107-19. PMID 21920761 DOI: 10.1016/j.bmc.2011.08.028  1
2011 Inagaki A, Sleddens-Linkels E, van Cappellen WA, Hibbert RG, Sixma TK, Hoeijmakers JH, Grootegoed JA, Baarends WM. Human RAD18 interacts with ubiquitylated chromatin components and facilitates RAD9 recruitment to DNA double strand breaks. Plos One. 6: e23155. PMID 21858012 DOI: 10.1371/journal.pone.0023155  1
2011 Monti MC, Cohen SX, Fish A, Winterwerp HH, Barendregt A, Friedhoff P, Perrakis A, Heck AJ, Sixma TK, van den Heuvel RH, Lebbink JH. Native mass spectrometry provides direct evidence for DNA mismatch-induced regulation of asymmetric nucleotide binding in mismatch repair protein MutS. Nucleic Acids Research. 39: 8052-64. PMID 21737427 DOI: 10.1093/nar/gkr498  1
2011 Huang A, Hibbert RG, de Jong RN, Das D, Sixma TK, Boelens R. Symmetry and asymmetry of the RING-RING dimer of Rad18. Journal of Molecular Biology. 410: 424-35. PMID 21549715 DOI: 10.1016/j.jmb.2011.04.051  1
2011 Winkler I, Marx AD, Lariviere D, Heinze RJ, Cristovao M, Reumer A, Curth U, Sixma TK, Friedhoff P. Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli. The Journal of Biological Chemistry. 286: 17326-37. PMID 21454657 DOI: 10.1074/jbc.M110.187641  1
2011 Luna-Vargas MP, Christodoulou E, Alfieri A, van Dijk WJ, Stadnik M, Hibbert RG, Sahtoe DD, Clerici M, Marco VD, Littler D, Celie PH, Sixma TK, Perrakis A. Enabling high-throughput ligation-independent cloning and protein expression for the family of ubiquitin specific proteases. Journal of Structural Biology. 175: 113-9. PMID 21453775 DOI: 10.1016/j.jsb.2011.03.017  1
2011 Hibbert RG, Huang A, Boelens R, Sixma TK. E3 ligase Rad18 promotes monoubiquitination rather than ubiquitin chain formation by E2 enzyme Rad6. Proceedings of the National Academy of Sciences of the United States of America. 108: 5590-5. PMID 21422291 DOI: 10.1073/pnas.1017516108  1
2011 Luna-Vargas MP, Faesen AC, van Dijk WJ, Rape M, Fish A, Sixma TK. Ubiquitin-specific protease 4 is inhibited by its ubiquitin-like domain. Embo Reports. 12: 365-72. PMID 21415856 DOI: 10.1038/embor.2011.33  1
2011 Edink E, Rucktooa P, Retra K, Akdemir A, Nahar T, Zuiderveld O, van Elk R, Janssen E, van Nierop P, van Muijlwijk-Koezen J, Smit AB, Sixma TK, Leurs R, de Esch IJ. Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis. Journal of the American Chemical Society. 133: 5363-71. PMID 21322593 DOI: 10.1021/ja110571r  1
2011 Abrahams JP, Apweiler R, Balling R, Bertero MG, Bujnicki JM, Chayen NE, Chène P, Corthals GL, Dyl?g T, Förster F, Heck AJ, Henderson PJ, Herwig R, Jehenson P, Kokalj SJ, ... ... Sixma TK, et al. "4D Biology for health and disease" workshop report. New Biotechnology. 28: 291-3. PMID 20951846 DOI: 10.1016/j.nbt.2010.10.003  1
2011 Winkler I, Marx AD, Lariviere D, Manelyte L, Giron-Monzon L, Heinze RJ, Cristovao M, Reumer A, Curth U, Sixma TK, Friedhoff P. Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli (Journal of Biological Chemistry (2011) 286, (17326-17337)) Journal of Biological Chemistry. 286: 22706. DOI: 10.1074/jbc.A110.187641  1
2010 El Oualid F, Merkx R, Ekkebus R, Hameed DS, Smit JJ, de Jong A, Hilkmann H, Sixma TK, Ovaa H. Chemical synthesis of ubiquitin, ubiquitin-based probes, and diubiquitin. Angewandte Chemie (International Ed. in English). 49: 10149-53. PMID 21117055 DOI: 10.1002/anie.201005995  1
2010 Shanmugham A, Fish A, Luna-Vargas MP, Faesen AC, El Oualid F, Sixma TK, Ovaa H. Nonhydrolyzable ubiquitin-isopeptide isosteres as deubiquitinating enzyme probes. Journal of the American Chemical Society. 132: 8834-5. PMID 20540574 DOI: 10.1021/ja101803s  1
2010 Lebbink JH, Fish A, Reumer A, Natrajan G, Winterwerp HH, Sixma TK. Magnesium coordination controls the molecular switch function of DNA mismatch repair protein MutS. The Journal of Biological Chemistry. 285: 13131-41. PMID 20167596 DOI: 10.1074/jbc.M109.066001  1
2009 Kasheverov IE, Zhmak MN, Fish A, Rucktooa P, Khruschov AY, Osipov AV, Ziganshin RH, D'hoedt D, Bertrand D, Sixma TK, Smit AB, Tsetlin VI. Interaction of alpha-conotoxin ImII and its analogs with nicotinic receptors and acetylcholine-binding proteins: additional binding sites on Torpedo receptor. Journal of Neurochemistry. 111: 934-44. PMID 19712060 DOI: 10.1111/j.1471-4159.2009.06359.x  1
2009 Rucktooa P, Smit AB, Sixma TK. Insight in nAChR subtype selectivity from AChBP crystal structures. Biochemical Pharmacology. 78: 777-87. PMID 19576182 DOI: 10.1016/j.bcp.2009.06.098  1
2009 Marteijn JA, van der Meer LT, Smit JJ, Noordermeer SM, Wissink W, Jansen P, Swarts HG, Hibbert RG, de Witte T, Sixma TK, Jansen JH, van der Reijden BA. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains. Leukemia. 23: 1480-9. PMID 19340006 DOI: 10.1038/leu.2009.57  1
2009 Ulens C, Akdemir A, Jongejan A, van Elk R, Bertrand S, Perrakis A, Leurs R, Smit AB, Sixma TK, Bertrand D, de Esch IJ. Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis. Journal of Medicinal Chemistry. 52: 2372-83. PMID 19331415 DOI: 10.1021/jm801400g  1
2009 Hibbert RG, Mattiroli F, Sixma TK. Structural aspects of multi-domain RING/Ubox E3 ligases in DNA repair. Dna Repair. 8: 525-35. PMID 19249250 DOI: 10.1016/j.dnarep.2009.01.014  1
2009 Knipscheer P, Klug H, Sixma TK, Pichler A. Preparation of sumoylated substrates for biochemical analysis. Methods in Molecular Biology (Clifton, N.J.). 497: 201-10. PMID 19107419 DOI: 10.1007/978-1-59745-566-4_13  1
2008 Crosetto N, Bienko M, Hibbert RG, Perica T, Ambrogio C, Kensche T, Hofmann K, Sixma TK, Dikic I. Human Wrnip1 is localized in replication factories in a ubiquitin-binding zinc finger-dependent manner. The Journal of Biological Chemistry. 283: 35173-85. PMID 18842586 DOI: 10.1074/jbc.M803219200  1
2008 van Leuken RJ, Luna-Vargas MP, Sixma TK, Wolthuis RM, Medema RH. Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. Cell Cycle (Georgetown, Tex.). 7: 2710-9. PMID 18728397  1
2008 Knipscheer P, Flotho A, Klug H, Olsen JV, van Dijk WJ, Fish A, Johnson ES, Mann M, Sixma TK, Pichler A. Ubc9 sumoylation regulates SUMO target discrimination. Molecular Cell. 31: 371-82. PMID 18691969 DOI: 10.1016/j.molcel.2008.05.022  1
2008 Schwamborn K, Knipscheer P, van Dijk E, van Dijk WJ, Sixma TK, Meloen RH, Langedijk JP. SUMO assay with peptide arrays on solid support: insights into SUMO target sites. Journal of Biochemistry. 144: 39-49. PMID 18344540 DOI: 10.1093/jb/mvn039  1
2008 Cohen SX, Ben Jelloul M, Long F, Vagin A, Knipscheer P, Lebbink J, Sixma TK, Lamzin VS, Murshudov GN, Perrakis A. ARP/wARP and molecular replacement: the next generation. Acta Crystallographica. Section D, Biological Crystallography. 64: 49-60. PMID 18094467 DOI: 10.1107/S0907444907047580  1
2007 Knipscheer P, Sixma TK. Protein-protein interactions regulate Ubl conjugation. Current Opinion in Structural Biology. 17: 665-73. PMID 17933515 DOI: 10.1016/j.sbi.2007.09.001  1
2007 Notenboom V, Hibbert RG, van Rossum-Fikkert SE, Olsen JV, Mann M, Sixma TK. Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification. Nucleic Acids Research. 35: 5819-30. PMID 17720710 DOI: 10.1093/nar/gkm615  1
2007 Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ. AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. The Embo Journal. 26: 3858-67. PMID 17660751 DOI: 10.1038/sj.emboj.7601785  1
2007 Sixma TK. Nicotinic receptor structure emerging slowly. Nature Neuroscience. 10: 937-8. PMID 17657233 DOI: 10.1038/nn0807-937  1
2007 Knipscheer P, van Dijk WJ, Olsen JV, Mann M, Sixma TK. Noncovalent interaction between Ubc9 and SUMO promotes SUMO chain formation. The Embo Journal. 26: 2797-807. PMID 17491593 DOI: 10.1038/sj.emboj.7601711  1
2006 Smit AB, Celie PH, Kasheverov IE, Mordvintsev DY, van Nierop P, Bertrand D, Tsetlin V, Sixma TK. Acetylcholine-binding proteins: functional and structural homologs of nicotinic acetylcholine receptors. Journal of Molecular Neuroscience : Mn. 30: 9-10. PMID 17192605 DOI: 10.1385/JMN:30:1:9  1
2006 Romier C, Ben Jelloul M, Albeck S, Buchwald G, Busso D, Celie PH, Christodoulou E, De Marco V, van Gerwen S, Knipscheer P, Lebbink JH, Notenboom V, Poterszman A, Rochel N, Cohen SX, ... ... Sixma TK, et al. Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies. Acta Crystallographica. Section D, Biological Crystallography. 62: 1232-42. PMID 17001100 DOI: 10.1107/S0907444906031003  1
2006 Aricescu AR, Assenberg R, Bill RM, Busso D, Chang VT, Davis SJ, Dubrovsky A, Gustafsson L, Hedfalk K, Heinemann U, Jones IM, Ksiazek D, Lang C, Maskos K, Messerschmidt A, ... ... Sixma TK, et al. Eukaryotic expression: developments for structural proteomics. Acta Crystallographica. Section D, Biological Crystallography. 62: 1114-24. PMID 17001089 DOI: 10.1107/S0907444906029805  1
2006 Knipscheer P, Sixma TK. Divide and conquer: the E2 active site. Nature Structural & Molecular Biology. 13: 474-6. PMID 16757944 DOI: 10.1038/nsmb0606-474  1
2006 Buchwald G, van der Stoop P, Weichenrieder O, Perrakis A, van Lohuizen M, Sixma TK. Structure and E3-ligase activity of the Ring-Ring complex of polycomb proteins Bmi1 and Ring1b. The Embo Journal. 25: 2465-74. PMID 16710298 DOI: 10.1038/sj.emboj.7601144  1
2006 Ulens C, Hogg RC, Celie PH, Bertrand D, Tsetlin V, Smit AB, Sixma TK. Structural determinants of selective alpha-conotoxin binding to a nicotinic acetylcholine receptor homolog AChBP. Proceedings of the National Academy of Sciences of the United States of America. 103: 3615-20. PMID 16505382 DOI: 10.1073/pnas.0507889103  1
2006 Lebbink JH, Georgijevic D, Natrajan G, Fish A, Winterwerp HH, Sixma TK, de Wind N. Dual role of MutS glutamate 38 in DNA mismatch discrimination and in the authorization of repair. The Embo Journal. 25: 409-19. PMID 16407973 DOI: 10.1038/sj.emboj.7600936  1
2005 Nijman SM, Luna-Vargas MP, Velds A, Brummelkamp TR, Dirac AM, Sixma TK, Bernards R. A genomic and functional inventory of deubiquitinating enzymes. Cell. 123: 773-86. PMID 16325574 DOI: 10.1016/j.cell.2005.11.007  1
2005 Celie PH, Kasheverov IE, Mordvintsev DY, Hogg RC, van Nierop P, van Elk R, van Rossum-Fikkert SE, Zhmak MN, Bertrand D, Tsetlin V, Sixma TK, Smit AB. Crystal structure of nicotinic acetylcholine receptor homolog AChBP in complex with an alpha-conotoxin PnIA variant. Nature Structural & Molecular Biology. 12: 582-8. PMID 15951818 DOI: 10.1038/nsmb951  1
2005 Celie PH, Klaassen RV, van Rossum-Fikkert SE, van Elk R, van Nierop P, Smit AB, Sixma TK. Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 280: 26457-66. PMID 15899893 DOI: 10.1074/jbc.M414476200  1
2005 Lebbink JH, Sixma TK. Variations on the ABC. Structure (London, England : 1993). 13: 498-500. PMID 15837186 DOI: 10.1016/j.str.2005.03.003  1
2005 Pichler A, Knipscheer P, Oberhofer E, van Dijk WJ, Körner R, Olsen JV, Jentsch S, Melchior F, Sixma TK. SUMO modification of the ubiquitin-conjugating enzyme E2-25K. Nature Structural & Molecular Biology. 12: 264-9. PMID 15723079 DOI: 10.1038/nsmb903  1
2004 Pichler A, Knipscheer P, Saitoh H, Sixma TK, Melchior F. The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type. Nature Structural & Molecular Biology. 11: 984-91. PMID 15378033 DOI: 10.1038/nsmb834  1
2004 Watkins S, van Pouderoyen G, Sixma TK. Structural analysis of the bipartite DNA-binding domain of Tc3 transposase bound to transposon DNA. Nucleic Acids Research. 32: 4306-12. PMID 15304566 DOI: 10.1093/nar/gkh770  1
2004 Lamers MH, Georgijevic D, Lebbink JH, Winterwerp HH, Agianian B, de Wind N, Sixma TK. ATP increases the affinity between MutS ATPase domains. Implications for ATP hydrolysis and conformational changes. The Journal of Biological Chemistry. 279: 43879-85. PMID 15297450 DOI: 10.1074/jbc.M406380200  1
2004 Celie PH, van Rossum-Fikkert SE, van Dijk WJ, Brejc K, Smit AB, Sixma TK. Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures. Neuron. 41: 907-14. PMID 15046723 DOI: 10.1016/S0896-6273(04)00115-1  1
2003 Smit AB, Brejc K, Syed N, Sixma TK. Structure and function of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor. Annals of the New York Academy of Sciences. 998: 81-92. PMID 14592865 DOI: 10.1196/annals.1254.010  1
2003 Natrajan G, Lamers MH, Enzlin JH, Winterwerp HH, Perrakis A, Sixma TK. Structures of Escherichia coli DNA mismatch repair enzyme MutS in complex with different mismatches: a common recognition mode for diverse substrates. Nucleic Acids Research. 31: 4814-21. PMID 12907723 DOI: 10.1093/nar/gkg677  1
2003 Sixma TK, Smit AB. Acetylcholine binding protein (AChBP): a secreted glial protein that provides a high-resolution model for the extracellular domain of pentameric ligand-gated ion channels. Annual Review of Biophysics and Biomolecular Structure. 32: 311-34. PMID 12695308 DOI: 10.1146/annurev.biophys.32.110601.142536  1
2003 Lamers MH, Winterwerp HH, Sixma TK. The alternating ATPase domains of MutS control DNA mismatch repair. The Embo Journal. 22: 746-56. PMID 12554674 DOI: 10.1093/emboj/cdg064  1
2002 Back JW, Notenboom V, de Koning LJ, Muijsers AO, Sixma TK, de Koster CG, de Jong L. Identification of cross-linked peptides for protein interaction studies using mass spectrometry and 18O labeling. Analytical Chemistry. 74: 4417-22. PMID 12236350 DOI: 10.1021/ac0257492  1
2002 Brejc K, van Dijk WJ, Smit AB, Sixma TK. The 2.7 A structure of AChBP, homologue of the ligand-binding domain of the nicotinic acetylcholine receptor. Novartis Foundation Symposium. 245: 22-9; discussion 29-. PMID 12027010  1
2001 Harel M, Kasher R, Nicolas A, Guss JM, Balass M, Fridkin M, Smit AB, Brejc K, Sixma TK, Katchalski-Katzir E, Sussman JL, Fuchs S. The binding site of acetylcholine receptor as visualized in the X-Ray structure of a complex between alpha-bungarotoxin and a mimotope peptide. Neuron. 32: 265-75. PMID 11683996 DOI: 10.1016/S0896-6273(01)00461-5  1
2001 Brejc K, van Dijk WJ, Klaassen RV, Schuurmans M, van Der Oost J, Smit AB, Sixma TK. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors. Nature. 411: 269-76. PMID 11357122 DOI: 10.1038/35077011  1
2001 Smit AB, Syed NI, Schaap D, van Minnen J, Klumperman J, Kits KS, Lodder H, van der Schors RC, van Elk R, Sorgedrager B, Brejc K, Sixma TK, Geraerts WP. A glia-derived acetylcholine-binding protein that modulates synaptic transmission. Nature. 411: 261-8. PMID 11357121 DOI: 10.1038/35077000  1
2001 Sixma TK. DNA mismatch repair: MutS structures bound to mismatches. Current Opinion in Structural Biology. 11: 47-52. PMID 11179891 DOI: 10.1016/S0959-440X(00)00169-X  1
2000 Lamers MH, Perrakis A, Enzlin JH, Winterwerp HH, de Wind N, Sixma TK. The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch. Nature. 407: 711-7. PMID 11048711 DOI: 10.1038/35037523  1
2000 Jovine L, Hainzl T, Oubridge C, Scott WG, Li J, Sixma TK, Wonacott A, Skarzynski T, Nagai K. Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA. Structure (London, England : 1993). 8: 527-40. PMID 10801497 DOI: 10.1016/S0969-2126(00)00137-4  1
1997 Perrakis A, Sixma TK, Wilson KS, Lamzin VS. wARP: improvement and extension of crystallographic phases by weighted averaging of multiple-refined dummy atomic models. Acta Crystallographica. Section D, Biological Crystallography. 53: 448-55. PMID 15299911 DOI: 10.1107/S0907444997005696  1
1997 van Pouderoyen G, Ketting RF, Perrakis A, Plasterk RH, Sixma TK. Crystal structure of the specific DNA-binding domain of Tc3 transposase of C.elegans in complex with transposon DNA. The Embo Journal. 16: 6044-54. PMID 9312061 DOI: 10.1093/emboj/16.19.6044  1
1997 Tong H, Hateboer G, Perrakis A, Bernards R, Sixma TK. Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system. The Journal of Biological Chemistry. 272: 21381-7. PMID 9261152 DOI: 10.1074/jbc.272.34.21381  1
1997 Brejc K, Sixma TK, Kitts PA, Kain SR, Tsien RY, Ormö M, Remington SJ. Structural basis for dual excitation and photoisomerization of the Aequorea victoria green fluorescent protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 2306-11. PMID 9122190 DOI: 10.1073/pnas.94.6.2306  1
1994 Merritt EA, Pronk SE, Sixma TK, Kalk KH, van Zanten BA, Hol WG. Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution. Febs Letters. 337: 88-92. PMID 8276119 DOI: 10.1016/0014-5793(94)80635-7  1
1994 Merritt EA, Sixma TK, Kalk KH, van Zanten BA, Hol WG. Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT). Molecular Microbiology. 13: 745-53. PMID 7997185 DOI: 10.1111/j.1365-2958.1994.tb00467.x  1
1993 Sixma TK, Kalk KH, van Zanten BA, Dauter Z, Kingma J, Witholt B, Hol WG. Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. Journal of Molecular Biology. 230: 890-918. PMID 8478941 DOI: 10.1006/jmbi.1993.1209  1
1993 Sixma TK, Stein PE, Hol WG, Read RJ. Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity. Biochemistry. 32: 191-8. PMID 8418837 DOI: 10.1021/bi00052a025  1
1992 Sixma TK, Pronk SE, Kalk KH, van Zanten BA, Berghuis AM, Hol WG. Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature. 355: 561-4. PMID 1741035 DOI: 10.1038/355561a0  1
1992 Sixma TK, Aguirre A, Terwisscha van Scheltinga AC, Wartna ES, Kalk KH, Hol WG. Heat-labile enterotoxin crystal forms with variable A/B5 orientation. Analysis of conformational flexibility. Febs Letters. 305: 81-5. PMID 1618345 DOI: 10.1016/0014-5793(92)80869-I  1
1992 Sixma TK, Terwisscha van Scheltinga AC, Kalk KH, Zhou K, Wartna ES, Hol WG. X-ray studies reveal lanthanide binding sites at the A/B5 interface of E. coli heat labile enterotoxin. Febs Letters. 297: 179-82. PMID 1551426 DOI: 10.1016/0014-5793(92)80355-K  1
1992 Streatfield SJ, Sandkvist M, Sixma TK, Bagdasarian M, Hol WG, Hirst TR. Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo. Proceedings of the National Academy of Sciences of the United States of America. 89: 12140-4. PMID 1465452 DOI: 10.1073/pnas.89.24.12140  1
1991 Sixma TK, Pronk SE, Kalk KH, Wartna ES, van Zanten BA, Witholt B, Hol WG. Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature. 351: 371-7. PMID 2034287 DOI: 10.1038/351371a0  1
1986 Smaal EB, Sixma TK, Mandersloot JG, De Gier J. Differences in permeability of dioleoylphosphatidylcholine model membranes containing saturated or unsaturated phosphatidic acids Bioelectrochemistry and Bioenergetics. 15: 167-172. DOI: 10.1016/0302-4598(86)80024-1  1
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