Ronald T. Raines, Ph.D. - Publications

Affiliations: 
1989-2017 Biochemistry and Chemistry University of Wisconsin, Madison, Madison, WI 
 2017- Chemistry Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
chemical biology, protein design and engineering, enzymology, biofuels
Website:
http://raineslab.com

359 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Kilgore HR, Raines RT. n➝ π* Interactions Modulate the Properties of Cysteine Residues and Disulfide Bonds in Proteins. Journal of the American Chemical Society. PMID 30403347 DOI: 10.1021/jacs.8b09701  1
2018 Windsor IW, Palte MJ, Lukesh JC, Gold B, Forest KT, Raines RT. Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid. Journal of the American Chemical Society. PMID 30346745 DOI: 10.1021/jacs.8b07366  1
2018 Hoang TT, Tanrikulu IC, Vatland QA, Hoang TM, Raines RT. A Human Ribonuclease Variant and ERK-Pathway Inhibitors Exhibit Highly Synergistic Toxicity for Cancer Cells. Molecular Cancer Therapeutics. PMID 30282811 DOI: 10.1158/1535-7163.MCT-18-0724  1
2018 Ellison AJ, Raines RT. A pendant peptide endows a sunscreen with water-resistance. Organic & Biomolecular Chemistry. PMID 30256375 DOI: 10.1039/c8ob01773e  1
2018 Vasta JD, Raines RT. Collagen Prolyl 4-Hydroxylase as a Therapeutic Target. Journal of Medicinal Chemistry. PMID 29986141 DOI: 10.1021/acs.jmedchem.8b00822  1
2018 Windsor IW, Raines RT. A substrate selected by phage display exhibits enhanced side-chain hydrogen bonding to HIV-1 protease. Acta Crystallographica. Section D, Structural Biology. 74: 690-694. PMID 29968678 DOI: 10.1107/S2059798318006691  1
2018 Chyan W, Raines RT. Enzyme-Activated Fluorogenic Probes for Live-Cell and in Vivo Imaging. Acs Chemical Biology. PMID 29924581 DOI: 10.1021/acschembio.8b00371  1
2018 Thomas SP, Hoang TT, Ressler VT, Raines RT. Human angiogenin is a potent cytotoxin in the absence of ribonuclease inhibitor. Rna (New York, N.Y.). PMID 29748193 DOI: 10.1261/rna.065516.117  1
2018 Umlauf B, Mix KA, Grosskopf VA, Raines RT, Shusta EV. Site-Specific Antibody Functionalization Using Tetrazine-Styrene Cycloaddition. Bioconjugate Chemistry. PMID 29694034 DOI: 10.1021/acs.bioconjchem.8b00114  1
2018 Chyan W, Kilgore HR, Raines RT. Cytosolic Uptake of Large Monofunctionalized Dextrans. Bioconjugate Chemistry. PMID 29649361 DOI: 10.1021/acs.bioconjchem.8b00198  1
2017 Raines RT, Wennemers H. Peptides on the Rise. Accounts of Chemical Research. 50: 2419. PMID 29037047 DOI: 10.1021/acs.accounts.7b00471  1
2017 Mix KA, Lomax JE, Raines RT. Cytosolic Delivery of Proteins by Bioreversible Esterification. Journal of the American Chemical Society. PMID 28976737 DOI: 10.1021/jacs.7b06597  1
2017 Smith TP, Windsor IW, Forest KT, Raines RT. Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation. Journal of Medicinal Chemistry. PMID 28920684 DOI: 10.1021/acs.jmedchem.7b00952  1
2017 Newberry RW, Raines RT. The n→π* Interaction. Accounts of Chemical Research. PMID 28735540 DOI: 10.1021/acs.accounts.7b00121  1
2017 Newberry RW, Raines RT. 4-Fluoroprolines: Conformational Analysis and Effects on the Stability and Folding of Peptides and Proteins. Topics in Heterocyclic Chemistry. 48: 1-25. PMID 28690684 DOI: 10.1007/7081_2015_196  1
2017 Burke EG, Gold B, Hoang TT, Raines RT, Schomaker JM. Fine-tuning Strain and Electronic Activation of Strain-promoted 1,3-Dipolar Cycloadditions with Endocyclic Sulfamates in SNO-OCTs. Journal of the American Chemical Society. PMID 28505435 DOI: 10.1021/jacs.7b03943  1
2017 Lomax JE, Eller CH, Raines RT. Comparative functional analysis of ribonuclease 1 homologs: Molecular insights into evolving vertebrate physiology. The Biochemical Journal. PMID 28495858 DOI: 10.1042/BCJ20170173  1
2017 Chyan W, Kilgore HR, Gold B, Raines RT. Electronic and Steric Optimization of Fluorogenic Probes for Biomolecular Imaging. The Journal of Organic Chemistry. PMID 28345343 DOI: 10.1021/acs.joc.7b00285  1
2017 Hoang TT, Smith TP, Raines RT. A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity. Angewandte Chemie (International Ed. in English). PMID 28120377 DOI: 10.1002/anie.201611446  1
2016 Vasta JD, Choudhary A, Jensen KH, McGrath NA, Raines RT. Prolyl 4-Hydroxylase: Substrate Isosteres in Which an (E)- or (Z)-Alkene Replaces the Prolyl Peptide Bond. Biochemistry. PMID 28001367 DOI: 10.1021/acs.biochem.6b00976  1
2016 Hoang TT, Raines RT. Molecular basis for the autonomous promotion of cell proliferation by angiogenin. Nucleic Acids Research. PMID 27915233 DOI: 10.1093/nar/gkw1192  1
2016 Aronoff MR, Gold B, Raines RT. Rapid cycloaddition of a diazo group with an unstrained dipolarophile. Tetrahedron Letters. 57: 2347-2350. PMID 27909348 DOI: 10.1016/j.tetlet.2016.04.020  1
2016 Thomas SP, Kim E, Kim JS, Raines RT. Knockout of the Ribonuclease Inhibitor Gene Leaves Human Cells Vulnerable to Secretory Ribonucleases. Biochemistry. PMID 27806571 DOI: 10.1021/acs.biochem.6b01003  1
2016 Tanrikulu IC, Forticaux A, Jin S, Raines RT. Peptide tessellation yields micrometre-scale collagen triple helices. Nature Chemistry. 8: 1008-1014. PMID 27768103 DOI: 10.1038/nchem.2556  1
2016 Newberry RW, Raines RT. A prevalent intraresidue hydrogen bond stabilizes proteins. Nature Chemical Biology. PMID 27748749 DOI: 10.1038/nchembio.2206  1
2016 Mix KA, Aronoff MR, Raines RT. Diazo Compounds: Versatile Tools for Chemical Biology. Acs Chemical Biology. PMID 27739661 DOI: 10.1021/acschembio.6b00810  1
2016 Gold B, Aronoff MR, Raines RT. 1,3-Dipolar Cycloaddition with Diazo Groups: Noncovalent Interactions Overwhelm Strain. Organic Letters. PMID 27599159 DOI: 10.1021/acs.orglett.6b01938  1
2016 Newberry RW, Orke SJ, Raines RT. n→π* Interactions Are Competitive with Hydrogen Bonds. Organic Letters. PMID 27409515 DOI: 10.1021/acs.orglett.6b01655  1
2016 Arnold U, Raines RT. Replacing a single atom accelerates the folding of a protein and increases its thermostability. Organic & Biomolecular Chemistry. PMID 27336677 DOI: 10.1039/c6ob00980h  1
2016 Gold B, Aronoff MR, Raines RT. Decreasing Distortion Energies without Strain: Diazo-Selective 1,3-Dipolar Cycloadditions. The Journal of Organic Chemistry. PMID 27332711 DOI: 10.1021/acs.joc.6b00948  1
2016 Johnston SB, Raines RT. PTENpred: A Designer Protein Impact Predictor for PTEN-related Disorders. Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. PMID 27310656 DOI: 10.1089/cmb.2016.0058  1
2016 Vasta JD, Raines RT. Human Collagen Prolyl 4-Hydroxylase is Activated by Ligands for its Iron Center. Biochemistry. PMID 27183028 DOI: 10.1021/acs.biochem.6b00251  1
2016 Aronoff MR, Gold B, Raines RT. 1,3-Dipolar Cycloadditions of Diazo Compounds in the Presence of Azides. Organic Letters. PMID 26981746 DOI: 10.1021/acs.orglett.6b00278  1
2015 Porter DF, Koh YY, VanVeller B, Raines RT, Wickens M. Target selection by natural and redesigned PUF proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 26668354 DOI: 10.1073/pnas.1508501112  1
2015 Andersen KA, Smith TP, Lomax JE, Raines RT. Boronic Acid for the Traceless Delivery of Proteins into Cells. Acs Chemical Biology. PMID 26629587 DOI: 10.1021/acschembio.5b00966  1
2015 Vasta JD, Andersen KA, Deck KM, Nizzi CP, Eisenstein RS, Raines RT. Selective Inhibition of Collagen Prolyl 4-Hydroxylase in Human Cells. Acs Chemical Biology. PMID 26535807 DOI: 10.1021/acschembio.5b00749  1
2015 Eller CH, Chao TY, Singarapu KK, Ouerfelli O, Yang G, Markley JL, Danishefsky SJ, Raines RT. Human Cancer Antigen Globo H Is a Cell-Surface Ligand for Human Ribonuclease 1. Acs Central Science. 1: 181-190. PMID 26405690 DOI: 10.1021/acscentsci.5b00164  1
2015 Desai KK, Beltrame AL, Raines RT. Coevolution of RtcB and Archease created a multiple-turnover RNA ligase. Rna (New York, N.Y.). PMID 26385509 DOI: 10.1261/rna.052639.115  1
2015 Checco JW, Lee EF, Evangelista M, Sleebs NJ, Rogers K, Pettikiriarachchi A, Kershaw NJ, Eddinger GA, Belair DG, Wilson JL, Eller CH, Raines RT, Murphy WL, Smith BJ, Gellman SH, et al. α/β-Peptide Foldamers Targeting Intracellular Protein-Protein Interactions with Activity in Living Cells. Journal of the American Chemical Society. 137: 11365-75. PMID 26317395 DOI: 10.1021/jacs.5b05896  1
2015 Windsor IW, Raines RT. Fluorogenic Assay for Inhibitors of HIV-1 Protease with Sub-picomolar Affinity. Scientific Reports. 5: 11286. PMID 26261098 DOI: 10.1038/srep11286  1
2015 Ellison AJ, VanVeller B, Raines RT. Convenient Synthesis of Collagen-Related Tripeptides for Segment Condensation. Biopolymers. PMID 26172437 DOI: 10.1002/bip.22700  1
2015 Vasta JD, Raines RT. Selective inhibition of prolyl 4-hydroxylases by bipyridinedicarboxylates. Bioorganic & Medicinal Chemistry. 23: 3081-90. PMID 26022078 DOI: 10.1016/j.bmc.2015.05.003  1
2015 Newberry RW, VanVeller B, Raines RT. Thioamides in the collagen triple helix. Chemical Communications (Cambridge, England). 51: 9624-7. PMID 25967743 DOI: 10.1039/c5cc02685g  1
2015 Mix KA, Raines RT. Optimized diazo scaffold for protein esterification. Organic Letters. 17: 2358-61. PMID 25938936 DOI: 10.1021/acs.orglett.5b00840  1
2015 Underkofler KA, Teixeira RE, Pietsch SA, Knapp KG, Raines RT. Separation of Lignin from Corn Stover Hydrolysate with Quantitative Recovery of Ionic Liquid. Acs Sustainable Chemistry & Engineering. 3: 606-613. PMID 25866701 DOI: 10.1021/sc500731c  1
2015 Raines RT. Fluorescence polarization assay to quantify protein-protein interactions: an update. Methods in Molecular Biology (Clifton, N.J.). 1278: 323-7. PMID 25859958 DOI: 10.1007/978-1-4939-2425-7_19  1
2015 Andersen KA, Aronoff MR, McGrath NA, Raines RT. Diazo groups endure metabolism and enable chemoselectivity in cellulo. Journal of the American Chemical Society. 137: 2412-5. PMID 25658416 DOI: 10.1021/ja5095815  1
2015 Choudhary A, Kamer KJ, Shoulders MD, Raines RT. 4-ketoproline: An electrophilic proline analog for bioconjugation. Biopolymers. 104: 110-5. PMID 25656588 DOI: 10.1002/bip.22620  1
2015 Johnston SB, Raines RT. Conformational stability and catalytic activity of PTEN variants linked to cancers and autism spectrum disorders. Biochemistry. 54: 1576-82. PMID 25647146 DOI: 10.1021/acs.biochem.5b00028  1
2015 Andersen KA, Raines RT. Creating site-specific isopeptide linkages between proteins with the traceless Staudinger ligation. Methods in Molecular Biology (Clifton, N.J.). 1248: 55-65. PMID 25616325 DOI: 10.1007/978-1-4939-2020-4_4  1
2015 Johnston SB, Raines RT. Catalysis by the tumor-suppressor enzymes PTEN and PTEN-L. Plos One. 10: e0116898. PMID 25607987 DOI: 10.1371/journal.pone.0116898  1
2015 McGrath NA, Andersen KA, Davis AK, Lomax JE, Raines RT. Diazo compounds for the bioreversible esterification of proteins. Chemical Science (Royal Society of Chemistry : 2010). 6: 752-755. PMID 25544883 DOI: 10.1039/C4SC01768D  1
2015 Andersen KA, Martin LJ, Prince JM, Raines RT. Intrinsic site-selectivity of ubiquitin dimer formation. Protein Science : a Publication of the Protein Society. 24: 182-9. PMID 25401704 DOI: 10.1002/pro.2603  1
2015 Marshall CJ, Grosskopf VA, Moehling TJ, Tillotson BJ, Wiepz GJ, Abbott NL, Raines RT, Shusta EV. An evolved Mxe GyrA intein for enhanced production of fusion proteins. Acs Chemical Biology. 10: 527-38. PMID 25384269 DOI: 10.1021/cb500689g  1
2015 Tonelli M, Eller CH, Singarapu KK, Lee W, Bahrami A, Westler WM, Raines RT, Markley JL. Assignments of RNase A by ADAPT-NMR and enhancer. Biomolecular Nmr Assignments. 9: 81-8. PMID 24619609 DOI: 10.1007/s12104-014-9549-z  1
2015 Caes BR, Teixeira RE, Knapp KG, Raines RT. Biomass to Furanics: Renewable Routes to Chemicals and Fuels Acs Sustainable Chemistry and Engineering. 3: 2591-2605. DOI: 10.1021/acssuschemeng.5b00473  1
2014 Lukesh JC, Andersen KA, Wallin KK, Raines RT. Organocatalysts of oxidative protein folding inspired by protein disulfide isomerase. Organic & Biomolecular Chemistry. 12: 8598-602. PMID 25266373 DOI: 10.1039/c4ob01738b  1
2014 Tanrikulu IC, Raines RT. Optimal interstrand bridges for collagen-like biomaterials. Journal of the American Chemical Society. 136: 13490-3. PMID 25211141 DOI: 10.1021/ja505426g  1
2014 Eller CH, Yang G, Ouerfelli O, Raines RT. Affinity of monoclonal antibodies for Globo-series glycans. Carbohydrate Research. 397: 1-6. PMID 25163606 DOI: 10.1016/j.carres.2014.07.003  1
2014 Desai KK, Bingman CA, Cheng CL, Phillips GN, Raines RT. Structure of RNA 3'-phosphate cyclase bound to substrate RNA. Rna (New York, N.Y.). 20: 1560-6. PMID 25161314 DOI: 10.1261/rna.045823.114  1
2014 Eller CH, Lomax JE, Raines RT. Bovine brain ribonuclease is the functional homolog of human ribonuclease 1. The Journal of Biological Chemistry. 289: 25996-6006. PMID 25078100 DOI: 10.1074/jbc.M114.566166  1
2014 Lukesh JC, Wallin KK, Raines RT. Pyrazine-derived disulfide-reducing agent for chemical biology. Chemical Communications (Cambridge, England). 50: 9591-4. PMID 25014913 DOI: 10.1039/c4cc04491f  1
2014 Lomax JE, Bianchetti CM, Chang A, Phillips GN, Fox BG, Raines RT. Functional evolution of ribonuclease inhibitor: insights from birds and reptiles. Journal of Molecular Biology. 426: 3041-56. PMID 24941155 DOI: 10.1016/j.jmb.2014.06.007  1
2014 Choudhary A, Newberry RW, Raines RT. n→π* interactions engender chirality in carbonyl groups. Organic Letters. 16: 3421-3. PMID 24926562 DOI: 10.1021/ol5012967  1
2014 Chattopadhyay S, Guthrie KM, Teixeira L, Murphy CJ, Dubielzig RR, McAnulty JF, Raines RT. Anchoring a cytoactive factor in a wound bed promotes healing. Journal of Tissue Engineering and Regenerative Medicine. PMID 24677775 DOI: 10.1002/term.1886  1
2014 Zasadil LM, Andersen KA, Yeum D, Rocque GB, Wilke LG, Tevaarwerk AJ, Raines RT, Burkard ME, Weaver BA. Cytotoxicity of paclitaxel in breast cancer is due to chromosome missegregation on multipolar spindles. Science Translational Medicine. 6: 229ra43. PMID 24670687 DOI: 10.1126/scitranslmed.3007965  1
2014 Chattopadhyay S, Raines RT. Review collagen-based biomaterials for wound healing. Biopolymers. 101: 821-33. PMID 24633807 DOI: 10.1002/bip.22486  1
2014 Lavis LD, Raines RT. Bright building blocks for chemical biology. Acs Chemical Biology. 9: 855-66. PMID 24579725 DOI: 10.1021/cb500078u  1
2014 Newberry RW, Raines RT. A key n→π* Interaction in N-acyl homoserine lactones. Acs Chemical Biology. 9: 880-3. PMID 24556113 DOI: 10.1021/cb500022u  1
2014 Desai KK, Cheng CL, Bingman CA, Phillips GN, Raines RT. A tRNA splicing operon: Archease endows RtcB with dual GTP/ATP cofactor specificity and accelerates RNA ligation. Nucleic Acids Research. 42: 3931-42. PMID 24435797 DOI: 10.1093/nar/gkt1375  1
2014 D'Avino C, Paciello R, Riccio G, Coppola C, Coppola M, Laccetti P, Maurea N, Raines RT, De Lorenzo C. Effects of a second-generation human anti-ErbB2 ImmunoRNase on trastuzumab-resistant tumors and cardiac cells. Protein Engineering, Design & Selection : Peds. 27: 83-8. PMID 24421342 DOI: 10.1093/protein/gzt065  1
2014 Newberry RW, Bartlett GJ, VanVeller B, Woolfson DN, Raines RT. Signatures of n→π* interactions in proteins. Protein Science : a Publication of the Protein Society. 23: 284-8. PMID 24375625 DOI: 10.1002/pro.2413  1
2013 Caes BR, Palte MJ, Raines RT. Organocatalytic Conversion of Cellulose into a Platform Chemical. Chemical Science (Royal Society of Chemistry : 2010). 4: 196-199. PMID 24596655 DOI: 10.1039/C2SC21403B  1
2013 Vanveller B, Aronoff MR, Raines RT. A Divalent Protecting Group for Benzoxaboroles. Rsc Advances. 44: 21331-21334. PMID 24505552 DOI: 10.1039/C3RA44385J  1
2013 Bartlett GJ, Newberry RW, VanVeller B, Raines RT, Woolfson DN. Interplay of hydrogen bonds and n→π* interactions in proteins. Journal of the American Chemical Society. 135: 18682-8. PMID 24256417 DOI: 10.1021/ja4106122  1
2013 Lukesh JC, Vanveller B, Raines RT. Thiols and selenols as electron-relay catalysts for disulfide-bond reduction. Angewandte Chemie (International Ed. in English). 52: 12901-4. PMID 24123634 DOI: 10.1002/anie.201307481  1
2013 Aronoff MR, VanVeller B, Raines RT. Detection of boronic acids through excited-state intramolecular proton-transfer fluorescence. Organic Letters. 15: 5382-5. PMID 24099104 DOI: 10.1021/ol402714k  1
2013 Chou HH, Raines RT. Conversion of azides into diazo compounds in water. Journal of the American Chemical Society. 135: 14936-9. PMID 24053717 DOI: 10.1021/ja407822b  1
2013 Sundlass NK, Eller CH, Cui Q, Raines RT. Contribution of electrostatics to the binding of pancreatic-type ribonucleases to membranes. Biochemistry. 52: 6304-12. PMID 23947917 DOI: 10.1021/bi400619m  1
2013 Caes BR, Van Oosbree TR, Lu F, Ralph J, Maravelias CT, Raines RT. Simulated moving bed chromatography: separation and recovery of sugars and ionic liquid from biomass hydrolysates. Chemsuschem. 6: 2083-9. PMID 23939991 DOI: 10.1002/cssc.201300267  1
2013 Choudhary A, Fry CG, Kamer KJ, Raines RT. An n→π* interaction reduces the electrophilicity of the acceptor carbonyl group. Chemical Communications (Cambridge, England). 49: 8166-8. PMID 23928794 DOI: 10.1039/c3cc44573a  1
2013 Marshall CJ, Agarwal N, Kalia J, Grosskopf VA, McGrath NA, Abbott NL, Raines RT, Shusta EV. Facile chemical functionalization of proteins through intein-linked yeast display. Bioconjugate Chemistry. 24: 1634-44. PMID 23924245 DOI: 10.1021/bc4002618  1
2013 Rutkoski TJ, Kink JA, Strong LE, Raines RT. Human ribonuclease with a pendant poly(ethylene glycol) inhibits tumor growth in mice. Translational Oncology. 6: 392-7. PMID 23908681 DOI: 10.1593/tlo.13253  1
2013 Newberry RW, Raines RT. n→π* interactions in poly(lactic acid) suggest a role in protein folding. Chemical Communications (Cambridge, England). 49: 7699-701. PMID 23897514 DOI: 10.1039/c3cc44317e  1
2013 Guzei IA, Choudhary A, Raines RT. Pyramidalization of a carbonyl C atom in (2S)-N-(seleno-acet-yl)proline methyl ester. Acta Crystallographica. Section E, Structure Reports Online. 69: o805-6. PMID 23723945 DOI: 10.1107/S1600536813011112  1
2013 Vasta JD, Higgin JJ, Kersteen EA, Raines RT. Bioavailable affinity label for collagen prolyl 4-hydroxylase. Bioorganic & Medicinal Chemistry. 21: 3597-601. PMID 23702396 DOI: 10.1016/j.bmc.2013.04.057  1
2013 Newberry RW, VanVeller B, Guzei IA, Raines RT. n→π* interactions of amides and thioamides: implications for protein stability. Journal of the American Chemical Society. 135: 7843-6. PMID 23663100 DOI: 10.1021/ja4033583  1
2013 Levine MN, Hoang TT, Raines RT. Fluorogenic probe for constitutive cellular endocytosis. Chemistry & Biology. 20: 614-8. PMID 23601650 DOI: 10.1016/j.chembiol.2013.03.016  1
2013 Desai KK, Bingman CA, Phillips GN, Raines RT. Structures of the noncanonical RNA ligase RtcB reveal the mechanism of histidine guanylylation. Biochemistry. 52: 2518-25. PMID 23560983 DOI: 10.1021/bi4002375  1
2013 Chao TY, Raines RT. Fluorogenic label to quantify the cytosolic delivery of macromolecules. Molecular Biosystems. 9: 339-42. PMID 23340874 DOI: 10.1039/c3mb25552b  1
2013 Arnold U, Huck BR, Gellman SH, Raines RT. Protein prosthesis: β-peptides as reverse-turn surrogates. Protein Science : a Publication of the Protein Society. 22: 274-9. PMID 23238807 DOI: 10.1002/pro.2208  1
2013 Riccio G, D'Avino C, Raines RT, De Lorenzo C. A novel fully human antitumor immunoRNase resistant to the RNase inhibitor. Protein Engineering, Design & Selection : Peds. 26: 243-8. PMID 23232187 DOI: 10.1093/protein/gzs101  1
2013 Kamer KJ, Choudhary A, Raines RT. Intimate interactions with carbonyl groups: dipole-dipole or n→π*? The Journal of Organic Chemistry. 78: 2099-103. PMID 23163960 DOI: 10.1021/jo302265k  1
2012 McGrath NA, Raines RT. Diazo Compounds as Highly Tunable Reactants in 1,3-Dipolar Cycloaddition Reactions with Cycloalkynes(). Chemical Science (Royal Society of Chemistry : 2010). 3: 3237-3240. PMID 23227302 DOI: 10.1039/C2SC20806G  1
2012 Levine MN, Raines RT. Trimethyl lock: A trigger for molecular release in chemistry, biology, and pharmacology. Chemical Science (Royal Society of Chemistry : 2010). 3: 2412-2420. PMID 23181187 DOI: 10.1039/C2SC20536J  1
2012 Palte MJ, Davis AK, McGrath NA, Spiegel CA, Raines RT. Ribonucleoside 3'-phosphates as pro-moieties for an orally administered drug. Chemmedchem. 7: 1361-4. PMID 22807330 DOI: 10.1002/cmdc.201200243  1
2012 Ellis GA, McGrath NA, Palte MJ, Raines RT. Ribonuclease-Activated Cancer Prodrug. Acs Medicinal Chemistry Letters. 3: 268-272. PMID 22611478 DOI: 10.1021/ml2002554  1
2012 Krow GR, Shoulders MD, Edupuganti R, Gandla D, Yu F, Sonnet PE, Sender M, Choudhary A, DeBrosse C, Ross CW, Carroll P, Raines RT. Synthesis of 5-fluoro- and 5-hydroxymethanoprolines via lithiation of N-BOC-methanopyrrolidines. Constrained Cγ-exo and Cγ-endo Flp and Hyp conformer mimics. The Journal of Organic Chemistry. 77: 5331-44. PMID 22607128 DOI: 10.1021/jo300700a  1
2012 Chattopadhyay S, Murphy CJ, McAnulty JF, Raines RT. Peptides that anneal to natural collagen in vitro and ex vivo. Organic & Biomolecular Chemistry. 10: 5892-7. PMID 22522497 DOI: 10.1039/c2ob25190f  1
2012 Palte MJ, Raines RT. Interaction of nucleic acids with the glycocalyx. Journal of the American Chemical Society. 134: 6218-23. PMID 22400897 DOI: 10.1021/ja2106477  1
2012 Lukesh JC, Palte MJ, Raines RT. A potent, versatile disulfide-reducing agent from aspartic acid. Journal of the American Chemical Society. 134: 4057-9. PMID 22353145 DOI: 10.1021/ja211931f  1
2012 Desai KK, Raines RT. tRNA ligase catalyzes the GTP-dependent ligation of RNA with 3'-phosphate and 5'-hydroxyl termini. Biochemistry. 51: 1333-5. PMID 22320833 DOI: 10.1021/bi201921a  1
2012 Ellis GA, Palte MJ, Raines RT. Boronate-mediated biologic delivery. Journal of the American Chemical Society. 134: 3631-4. PMID 22303837 DOI: 10.1021/ja210719s  1
2012 Lomax JE, Eller CH, Raines RT. Rational design and evaluation of mammalian ribonuclease cytotoxins. Methods in Enzymology. 502: 273-90. PMID 22208989 DOI: 10.1016/B978-0-12-416039-2.00014-8  1
2012 Choudhary A, Kamer KJ, Raines RT. A conserved interaction with the chromophore of fluorescent proteins. Protein Science : a Publication of the Protein Society. 21: 171-7. PMID 22057893 DOI: 10.1002/pro.762  1
2012 Sen SM, Binder JB, Raines RT, Maravelias CT. Conversion of biomass to sugars via ionic liquid hydrolysis: Process synthesis and economic evaluation Biofuels, Bioproducts and Biorefining. 6: 444-452. DOI: 10.1002/bbb.1336  1
2011 Sundlass NK, Raines RT. Arginine residues are more effective than lysine residues in eliciting the cellular uptake of onconase. Biochemistry. 50: 10293-9. PMID 21980976 DOI: 10.1021/bi200979k  1
2011 Choudhary A, Kamer KJ, Raines RT. An n→π* interaction in aspirin: implications for structure and reactivity. The Journal of Organic Chemistry. 76: 7933-7. PMID 21842865 DOI: 10.1021/jo201389d  1
2011 Cuchillo CM, Nogués MV, Raines RT. Bovine pancreatic ribonuclease: fifty years of the first enzymatic reaction mechanism. Biochemistry. 50: 7835-41. PMID 21838247 DOI: 10.1021/bi201075b  1
2011 Levine MN, Raines RT. Sensitive fluorogenic substrate for alkaline phosphatase. Analytical Biochemistry. 418: 247-52. PMID 21827735 DOI: 10.1016/j.ab.2011.07.021  1
2011 Chao TY, Raines RT. Mechanism of ribonuclease A endocytosis: analogies to cell-penetrating peptides. Biochemistry. 50: 8374-82. PMID 21827164 DOI: 10.1021/bi2009079  1
2011 Choudhary A, Raines RT. An evaluation of peptide-bond isosteres. Chembiochem : a European Journal of Chemical Biology. 12: 1801-7. PMID 21751326 DOI: 10.1002/cbic.201100272  1
2011 McGrath NA, Raines RT. Chemoselectivity in chemical biology: acyl transfer reactions with sulfur and selenium. Accounts of Chemical Research. 44: 752-61. PMID 21639109 DOI: 10.1021/ar200081s  1
2011 Rutkoski TJ, Kink JA, Strong LE, Raines RT. Site-specific PEGylation endows a mammalian ribonuclease with antitumor activity. Cancer Biology & Therapy. 12: 208-14. PMID 21633186 DOI: 10.4161/cbt.12.3.15959  1
2011 Smith BD, Higgin JJ, Raines RT. Site-specific folate conjugation to a cytotoxic protein. Bioorganic & Medicinal Chemistry Letters. 21: 5029-32. PMID 21570289 DOI: 10.1016/j.bmcl.2011.04.081  1
2011 Krow GR, Edupuganti R, Gandla D, Yu F, Sender M, Sonnet PE, Zdilla MJ, DeBrosse C, Cannon KC, Ross CW, Choudhary A, Shoulders MD, Raines RT. Synthesis of conformationally constrained 5-fluoro- and 5-hydroxymethanopyrrolidines. Ring-puckered mimics of gauche- and anti-3-fluoro- and 3-hydroxypyrrolidines. The Journal of Organic Chemistry. 76: 3626-34. PMID 21500838 DOI: 10.1021/jo200117p  1
2011 Shoulders MD, Raines RT. Interstrand dipole-dipole interactions can stabilize the collagen triple helix. The Journal of Biological Chemistry. 286: 22905-12. PMID 21482820 DOI: 10.1074/jbc.M110.199984  1
2011 Choudhary A, Raines RT. Signature of n→π* interactions in α-helices. Protein Science : a Publication of the Protein Society. 20: 1077-81. PMID 21442680 DOI: 10.1002/pro.627  1
2011 Caes BR, Raines RT. Conversion of fructose into 5-(hydroxymethyl)furfural in sulfolane. Chemsuschem. 4: 353-6. PMID 21394925 DOI: 10.1002/cssc.201000397  1
2011 Lavis LD, Chao TY, Raines RT. Synthesis and utility of fluorogenic acetoxymethyl ethers. Chemical Science (Royal Society of Chemistry : 2010). 2: 521-530. PMID 21394227 DOI: 10.1039/C0SC00466A  1
2011 Pinkas DM, Ding S, Raines RT, Barron AE. Tunable, post-translational hydroxylation of collagen Domains in Escherichia coli. Acs Chemical Biology. 6: 320-4. PMID 21210682 DOI: 10.1021/cb100298r  1
2011 Thiyagarajan N, Smith BD, Raines RT, Acharya KR. Functional and structural analyses of N-acylsulfonamide-linked dinucleoside inhibitors of RNase A. The Febs Journal. 278: 541-9. PMID 21205197 DOI: 10.1111/j.1742-4658.2010.07976.x  1
2011 Ellis GA, Hornung ML, Raines RT. Potentiation of ribonuclease cytotoxicity by a poly(amidoamine) dendrimer. Bioorganic & Medicinal Chemistry Letters. 21: 2756-8. PMID 21144746 DOI: 10.1016/j.bmcl.2010.11.028  1
2011 Ma L, Sundlass NK, Raines RT, Cui Q. Disruption and formation of surface salt bridges are coupled to DNA binding by the integration host factor: a computational analysis. Biochemistry. 50: 266-75. PMID 21121696 DOI: 10.1021/bi101096k  1
2011 Watkins RW, Arnold U, Raines RT. Ribonuclease S redux. Chemical Communications (Cambridge, England). 47: 973-5. PMID 21079871 DOI: 10.1039/c0cc03864d  1
2011 Choudhary A, Pua KH, Raines RT. Quantum mechanical origin of the conformational preferences of 4-thiaproline and its S-oxides. Amino Acids. 41: 181-6. PMID 20221839 DOI: 10.1007/s00726-010-0504-8  1
2011 Caes BR, Binder JB, Blank JJ, Raines RT. Separable fluorous ionic liquids for the dissolution and saccharification of cellulose Green Chemistry. 13: 2719-2722. DOI: 10.1039/c1gc15776k  1
2011 Raines RT. Chemical transformation of lignocellulosic biomass into furanics and sugars Acs National Meeting Book of Abstracts 1
2010 Choudhary A, Fry CG, Raines RT. Modulation of an n→π* interaction with α-fluoro groups. Arkivoc : Free Online Journal of Organic Chemistry / Arkat-Usa, Inc. 2010: 251-262. PMID 21643549  1
2010 Chao TY, Lavis LD, Raines RT. Cellular uptake of ribonuclease A relies on anionic glycans. Biochemistry. 49: 10666-73. PMID 21062061 DOI: 10.1021/bi1013485  1
2010 Martin LJ, Raines RT. Carpe diubiquitin. Angewandte Chemie (International Ed. in English). 49: 9042-4. PMID 21053237 DOI: 10.1002/anie.201005946  1
2010 Krow GR, Liu N, Sender M, Lin G, Centafont R, Sonnet PE, DeBrosse C, Ross CW, Carroll PJ, Shoulders MD, Raines RT. Oligomers of a 5-carboxy-methanopyrrolidine β-amino acid. A search for order. Organic Letters. 12: 5438-41. PMID 21043445 DOI: 10.1021/ol1022917  1
2010 Binder JB, Blank JJ, Cefali AV, Raines RT. Synthesis of furfural from xylose and xylan. Chemsuschem. 3: 1268-72. PMID 20836121 DOI: 10.1002/cssc.201000181  1
2010 Rutkoski TJ, Kink JA, Strong LE, Schilling CI, Raines RT. Antitumor activity of ribonuclease multimers created by site-specific covalent tethering. Bioconjugate Chemistry. 21: 1691-702. PMID 20704261 DOI: 10.1021/bc100292x  1
2010 Shoulders MD, Kotch FW, Choudhary A, Guzei IA, Raines RT. The aberrance of the 4S diastereomer of 4-hydroxyproline. Journal of the American Chemical Society. 132: 10857-65. PMID 20681719 DOI: 10.1021/ja103082y  1
2010 Kalia J, Raines RT. Advances in Bioconjugation. Current Organic Chemistry. 14: 138-147. PMID 20622973 DOI: 10.2174/138527210790069839  1
2010 Bartlett GJ, Choudhary A, Raines RT, Woolfson DN. n-->pi* interactions in proteins. Nature Chemical Biology. 6: 615-20. PMID 20622857 DOI: 10.1038/nchembio.406  1
2010 Choudhary A, Kamer KJ, Powner MW, Sutherland JD, Raines RT. A stereoelectronic effect in prebiotic nucleotide synthesis. Acs Chemical Biology. 5: 655-7. PMID 20499895 DOI: 10.1021/cb100093g  1
2010 Jakobsche CE, Choudhary A, Miller SJ, Raines RT. n --> pi* Interaction and n)(pi Pauli repulsion are antagonistic for protein stability. Journal of the American Chemical Society. 132: 6651-3. PMID 20420451 DOI: 10.1021/ja100931y  1
2010 Gorres KL, Raines RT. Prolyl 4-hydroxylase. Critical Reviews in Biochemistry and Molecular Biology. 45: 106-24. PMID 20199358 DOI: 10.3109/10409231003627991  1
2010 Binder JB, Raines RT. Fermentable sugars by chemical hydrolysis of biomass. Proceedings of the National Academy of Sciences of the United States of America. 107: 4516-21. PMID 20194793 DOI: 10.1073/pnas.0912073107  1
2010 Shoulders MD, Satyshur KA, Forest KT, Raines RT. Stereoelectronic and steric effects in side chains preorganize a protein main chain. Proceedings of the National Academy of Sciences of the United States of America. 107: 559-64. PMID 20080719 DOI: 10.1073/pnas.0909592107  1
2010 Binder JB, Cefali AV, Blank JJ, Raines RT. Mechanistic insights on the conversion of sugars into 5- hydroxymethylfurfural Energy and Environmental Science. 3: 765-771. DOI: 10.1039/b923961h  1
2010 Choudhary A, Fry CG, Raines RT. Modulation of an np* interaction with a-fluoro groups Arkivoc. 2010: 251-262.  1
2009 Kalia J, Raines RT. 1,9-Bis(2-pyridyl)-1,2,8,9-tetrathia-5-oxanonane. Molbank. 2009: M642. PMID 20467570 DOI: 10.3390/M642  1
2009 Allen MJ, Wangkanont K, Raines RT, Kiessling LL. ROMP from ROMP: A New Approach to Graft Copolymer Synthesis. Macromolecules. 42: 4023-4027. PMID 20161406 DOI: 10.1021/ma900056b  1
2009 Gorres KL, Pua KH, Raines RT. Stringency of the 2-His-1-Asp active-site motif in prolyl 4-hydroxylase. Plos One. 4: e7635. PMID 19890397 DOI: 10.1371/journal.pone.0007635  1
2009 Krow GR, Edupuganti R, Gandla D, Choudhary A, Lin G, Sonnet PE, DeBrosse C, Ross CW, Cannon KC, Raines RT. 5(6)-anti-Substituted-2-azabicyclo[2.1.1]hexanes: a nucleophilic displacement route. The Journal of Organic Chemistry. 74: 8232-42. PMID 19799411 DOI: 10.1021/jo901725k  1
2009 Watkins RW, Lavis LD, Kung VM, Los GV, Raines RT. Fluorogenic affinity label for the facile, rapid imaging of proteins in live cells. Organic & Biomolecular Chemistry. 7: 3969-75. PMID 19763299 DOI: 10.1039/b907664f  1
2009 Derewenda U, Boczek T, Gorres KL, Yu M, Hung LW, Cooper D, Joachimiak A, Raines RT, Derewenda ZS. Structure and function of Bacillus subtilis YphP, a prokaryotic disulfide isomerase with a CXC catalytic motif . Biochemistry. 48: 8664-71. PMID 19653655 DOI: 10.1021/bi900437z  1
2009 Tam A, Raines RT. Protein engineering with the traceless Staudinger ligation. Methods in Enzymology. 462: 25-44. PMID 19632468 DOI: 10.1016/S0076-6879(09)62002-4  1
2009 Turcotte RF, Lavis LD, Raines RT. Onconase cytotoxicity relies on the distribution of its positive charge. The Febs Journal. 276: 3846-57. PMID 19523116 DOI: 10.1111/j.1742-4658.2009.07098.x  1
2009 Choudhary A, Gandla D, Krow GR, Raines RT. Nature of amide carbonyl--carbonyl interactions in proteins. Journal of the American Chemical Society. 131: 7244-6. PMID 19469574 DOI: 10.1021/ja901188y  1
2009 Shoulders MD, Kamer KJ, Raines RT. Origin of the stability conferred upon collagen by fluorination. Bioorganic & Medicinal Chemistry Letters. 19: 3859-62. PMID 19423349 DOI: 10.1016/j.bmcl.2009.03.168  1
2009 Dickson KA, Raines RT. Silencing an inhibitor unleashes a cytotoxic enzyme. Biochemistry. 48: 5051-3. PMID 19402708 DOI: 10.1021/bi900489y  1
2009 Shoulders MD, Raines RT. Modulating collagen triple-helix stability with 4-chloro, 4-fluoro, and 4-methylprolines. Advances in Experimental Medicine and Biology. 611: 251-2. PMID 19400182 DOI: 10.1007/978-0-387-73657-0_115  1
2009 Raines RT. Stronger and (now) longer synthetic collagen. Advances in Experimental Medicine and Biology. 611: xci-xcviii. PMID 19400067  1
2009 Dickson KA, Kang DK, Kwon YS, Kim JC, Leland PA, Kim BM, Chang SI, Raines RT. Ribonuclease inhibitor regulates neovascularization by human angiogenin. Biochemistry. 48: 3804-6. PMID 19354288 DOI: 10.1021/bi9005094  1
2009 Shoulders MD, Raines RT. Collagen structure and stability. Annual Review of Biochemistry. 78: 929-58. PMID 19344236 DOI: 10.1146/annurev.biochem.77.032207.120833  1
2009 Binder JB, Raines RT. Simple chemical transformation of lignocellulosic biomass into furans for fuels and chemicals. Journal of the American Chemical Society. 131: 1979-85. PMID 19159236 DOI: 10.1021/ja808537j  1
2009 Gorres KL, Raines RT. Direct and continuous assay for prolyl 4-hydroxylase. Analytical Biochemistry. 386: 181-5. PMID 19111518 DOI: 10.1016/j.ab.2008.11.046  1
2009 Myers EL, Raines RT. A phosphine-mediated conversion of azides into diazo compounds. Angewandte Chemie (International Ed. in English). 48: 2359-63. PMID 19035612 DOI: 10.1002/anie.200804689  1
2009 Tam A, Raines RT. Coulombic effects on the traceless Staudinger ligation in water. Bioorganic & Medicinal Chemistry. 17: 1055-63. PMID 18314338 DOI: 10.1016/j.bmc.2008.02.047  1
2008 Gottlieb D, Morin SA, Jin S, Raines RT. Self-Assembled Collagen-like Peptide Fibers as Templates for Metallic Nanowires. Journal of Materials Chemistry. 18: 3865. PMID 20130788 DOI: 10.1039/b807150k  1
2008 Chorghade MS, Mohapatra DK, Sahoo G, Gurjar MK, Mandlecha MV, Bhoite N, Moghe S, Raines RT. Practical syntheses of 4-fluoroprolines. Journal of Fluorine Chemistry. 129: 781-784. PMID 19727323 DOI: 10.1016/j.jfluchem.2008.06.024  1
2008 Turcotte RF, Raines RT. Design and characterization of an HIV-specific ribonuclease zymogen. Aids Research and Human Retroviruses. 24: 1357-63. PMID 19025416 DOI: 10.1089/aid.2008.0146  1
2008 Wennemers H, Raines RT. Peptides and peptidomimetics as prototypes. Current Opinion in Chemical Biology. 12: 690-1. PMID 18992842 DOI: 10.1016/j.cbpa.2008.10.015  1
2008 Binder JB, Raines RT. Olefin metathesis for chemical biology. Current Opinion in Chemical Biology. 12: 767-73. PMID 18935975 DOI: 10.1016/j.cbpa.2008.09.022  1
2008 Turcotte RF, Raines RT. Interaction of onconase with the human ribonuclease inhibitor protein. Biochemical and Biophysical Research Communications. 377: 512-4. PMID 18930025 DOI: 10.1016/j.bbrc.2008.10.032  1
2008 Kalia J, Raines RT. Hydrolytic stability of hydrazones and oximes. Angewandte Chemie (International Ed. in English). 47: 7523-6. PMID 18712739 DOI: 10.1002/anie.200802651  1
2008 Gorres KL, Edupuganti R, Krow GR, Raines RT. Conformational preferences of substrates for human prolyl 4-hydroxylase. Biochemistry. 47: 9447-55. PMID 18702512 DOI: 10.1021/bi8009373  1
2008 Rutkoski TJ, Raines RT. Evasion of ribonuclease inhibitor as a determinant of ribonuclease cytotoxicity. Current Pharmaceutical Biotechnology. 9: 185-9. PMID 18673284 DOI: 10.2174/138920108784567344  1
2008 Yatzeck MM, Lavis LD, Chao TY, Chandran SS, Raines RT. A highly sensitive fluorogenic probe for cytochrome P450 activity in live cells. Bioorganic & Medicinal Chemistry Letters. 18: 5864-6. PMID 18595692 DOI: 10.1016/j.bmcl.2008.06.015  1
2008 Raines RT. Jeremy R. Knowles (1935-2008). Acs Chemical Biology. 3: 262-4. PMID 18484705 DOI: 10.1021/cb800099n  1
2008 Tam A, Soellner MB, Raines RT. Electronic and steric effects on the rate of the traceless Staudinger ligation. Organic & Biomolecular Chemistry. 6: 1173-5. PMID 18362954 DOI: 10.1039/b802336k  1
2008 Lavis LD, Raines RT. Bright ideas for chemical biology. Acs Chemical Biology. 3: 142-55. PMID 18355003 DOI: 10.1021/cb700248m  1
2008 Smith BD, Raines RT. Genetic selection for peptide inhibitors of angiogenin. Protein Engineering, Design & Selection : Peds. 21: 289-94. PMID 18308863 DOI: 10.1093/protein/gzm089  1
2008 Levine MN, Lavis LD, Raines RT. Trimethyl lock: a stable chromogenic substrate for esterases. Molecules (Basel, Switzerland). 13: 204-11. PMID 18305412 DOI: 10.3390/molecules13020204  1
2008 Kotch FW, Guzei IA, Raines RT. Stabilization of the collagen triple helix by O-methylation of hydroxyproline residues. Journal of the American Chemical Society. 130: 2952-3. PMID 18271593 DOI: 10.1021/ja800225k  1
2008 Lee JE, Raines RT. Ribonucleases as novel chemotherapeutics : the ranpirnase example. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 22: 53-8. PMID 18215091  1
2008 Lee JE, Bae E, Bingman CA, Phillips GN, Raines RT. Structural basis for catalysis by onconase. Journal of Molecular Biology. 375: 165-77. PMID 18001769 DOI: 10.1016/j.jmb.2007.09.089  1
2008 Shoulders MD, Guzei IA, Raines RT. 4-chloroprolines: synthesis, conformational analysis, and effect on the collagen triple helix. Biopolymers. 89: 443-54. PMID 17937398 DOI: 10.1002/bip.20864  1
2008 Raines RT. Stronger and longer synthetic collagen Materials Research Society Symposium Proceedings. 1062: 1-9.  1
2007 Binder JB, Guzei IA, Raines RT. Salicylaldimine Ruthenium Alkylidene Complexes: Metathesis Catalysts Tuned for Protic Solvents. Advanced Synthesis & Catalysis. 349: 395-404. PMID 20657667 DOI: 10.1002/adsc.200600264  1
2007 Johnson RJ, Lavis LD, Raines RT. Intraspecies regulation of ribonucleolytic activity. Biochemistry. 46: 13131-40. PMID 17956129 DOI: 10.1021/bi701521q  1
2007 Fuchs SM, Rutkoski TJ, Kung VM, Groeschl RT, Raines RT. Increasing the potency of a cytotoxin with an arginine graft. Protein Engineering, Design & Selection : Peds. 20: 505-9. PMID 17954521 DOI: 10.1093/protein/gzm051  1
2007 Binder JB, Blank JJ, Raines RT. Olefin metathesis in homogeneous aqueous media catalyzed by conventional ruthenium catalysts. Organic Letters. 9: 4885-8. PMID 17949009 DOI: 10.1021/ol7022505  1
2007 Tam A, Arnold U, Soellner MB, Raines RT. Protein prosthesis: 1,5-disubstituted[1,2,3]triazoles as cis-peptide bond surrogates. Journal of the American Chemical Society. 129: 12670-1. PMID 17914828 DOI: 10.1021/ja075865s  1
2007 Kalia J, Raines RT. Catalysis of imido group hydrolysis in a maleimide conjugate. Bioorganic & Medicinal Chemistry Letters. 17: 6286-9. PMID 17881230 DOI: 10.1016/j.bmcl.2007.09.002  1
2007 Tam A, Soellner MB, Raines RT. Water-soluble phosphinothiols for traceless staudinger ligation and integration with expressed protein ligation. Journal of the American Chemical Society. 129: 11421-30. PMID 17713909 DOI: 10.1021/ja073204p  1
2007 Johnson RJ, Chao TY, Lavis LD, Raines RT. Cytotoxic ribonucleases: the dichotomy of Coulombic forces. Biochemistry. 46: 10308-16. PMID 17705507 DOI: 10.1021/bi700857u  1
2007 Govindaraju T, Bertics PJ, Raines RT, Abbott NL. Using measurements of anchoring energies of liquid crystals on surfaces to quantify proteins captured by immobilized ligands. Journal of the American Chemical Society. 129: 11223-31. PMID 17705384 DOI: 10.1021/ja073203x  1
2007 Lavis LD, Rutkoski TJ, Raines RT. Tuning the pK(a) of fluorescein to optimize binding assays. Analytical Chemistry. 79: 6775-82. PMID 17672523 DOI: 10.1021/ac070907g  1
2007 Johnson RJ, Lin SR, Raines RT. Genetic selection reveals the role of a buried, conserved polar residue. Protein Science : a Publication of the Protein Society. 16: 1609-16. PMID 17656580 DOI: 10.1110/ps.072938907  1
2007 Kalia J, Abbott NL, Raines RT. General method for site-specific protein immobilization by Staudinger ligation. Bioconjugate Chemistry. 18: 1064-9. PMID 17488064 DOI: 10.1021/bc0603034  1
2007 Johnson RJ, McCoy JG, Bingman CA, Phillips GN, Raines RT. Inhibition of human pancreatic ribonuclease by the human ribonuclease inhibitor protein. Journal of Molecular Biology. 368: 434-49. PMID 17350650 DOI: 10.1016/j.jmb.2007.02.005  1
2007 Fuchs SM, Raines RT. Arginine grafting to endow cell permeability. Acs Chemical Biology. 2: 167-70. PMID 17319644 DOI: 10.1021/cb600429k  1
2007 Jewell CM, Fuchs SM, Flessner RM, Raines RT, Lynn DM. Multilayered films fabricated from an oligoarginine-conjugated protein promote efficient surface-mediated protein transduction. Biomacromolecules. 8: 857-63. PMID 17269822 DOI: 10.1021/bm0609442  1
2007 Horng JC, Kotch FW, Raines RT. Is glycine a surrogate for a D-amino acid in the collagen triple helix? Protein Science : a Publication of the Protein Society. 16: 208-15. PMID 17189476 DOI: 10.1110/ps.062560107  1
2007 Raines RT. Hyperstable collagen based on 4-fluoroproline residues Acs Symposium Series. 949: 477-486.  1
2006 Soellner MB, Tam A, Raines RT. Staudinger ligation of peptides at non-glycyl residues. The Journal of Organic Chemistry. 71: 9824-30. PMID 17168602 DOI: 10.1021/jo0620056  1
2006 Kiessling LL, Wedde SG, Raines RT. Symbiosis: Chemical biology at Wisconsin. Acs Chemical Biology. 1: 481-4. PMID 17168530 DOI: 10.1021/cb600368z  1
2006 Lavis LD, Chao TY, Raines RT. Fluorogenic label for biomolecular imaging. Acs Chemical Biology. 1: 252-60. PMID 17163679 DOI: 10.1021/cb600132m  1
2006 Johnson RJ, Lin SR, Raines RT. A ribonuclease zymogen activated by the NS3 protease of the hepatitis C virus. The Febs Journal. 273: 5457-65. PMID 17116245 DOI: 10.1111/j.1742-4658.2006.05536.x  1
2006 Horng JC, Hawk AJ, Zhao Q, Benedict ES, Burke SD, Raines RT. Macrocyclic scaffold for the collagen triple helix. Organic Letters. 8: 4735-8. PMID 17020290 DOI: 10.1021/ol061771w  1
2006 Hodges JA, Raines RT. Energetics of an n --> pi interaction that impacts protein structure. Organic Letters. 8: 4695-7. PMID 17020280 DOI: 10.1021/ol061569t  1
2006 Schlieve CR, Tam A, Nilsson BL, Lieven CJ, Raines RT, Levin LA. Synthesis and characterization of a novel class of reducing agents that are highly neuroprotective for retinal ganglion cells. Experimental Eye Research. 83: 1252-9. PMID 16934805 DOI: 10.1016/j.exer.2006.07.002  1
2006 Liu X, Jang CH, Zheng F, Jürgensen A, Denlinger JD, Dickson KA, Raines RT, Abbott NL, Himpsel FJ. Characterization of protein immobilization at silver surfaces by near edge X-ray absorption fine structure spectroscopy. Langmuir : the Acs Journal of Surfaces and Colloids. 22: 7719-25. PMID 16922555 DOI: 10.1021/la060988w  1
2006 Smith BD, Raines RT. Genetic selection for critical residues in ribonucleases. Journal of Molecular Biology. 362: 459-78. PMID 16920150 DOI: 10.1016/j.jmb.2006.07.020  1
2006 Fuchs SM, Raines RT. Internalization of cationic peptides: the road less (or more?) traveled. Cellular and Molecular Life Sciences : Cmls. 63: 1819-22. PMID 16909213 DOI: 10.1007/s00018-006-6170-z  1
2006 Kalia J, Raines RT. Reactivity of intein thioesters: appending a functional group to a protein. Chembiochem : a European Journal of Chemical Biology. 7: 1375-83. PMID 16897799 DOI: 10.1002/cbic.200600150  1
2006 Soellner MB, Nilsson BL, Raines RT. Reaction mechanism and kinetics of the traceless Staudinger ligation. Journal of the American Chemical Society. 128: 8820-8. PMID 16819875 DOI: 10.1021/ja060484k  1
2006 Shoulders MD, Hodges JA, Raines RT. Reciprocity of steric and stereoelectronic effects in the collagen triple helix. Journal of the American Chemical Society. 128: 8112-3. PMID 16787056 DOI: 10.1021/ja061793d  1
2006 Lavis LD, Chao TY, Raines RT. Latent blue and red fluorophores based on the trimethyl lock. Chembiochem : a European Journal of Chemical Biology. 7: 1151-4. PMID 16755624 DOI: 10.1002/cbic.200500559  1
2006 Allen MJ, Raines RT, Kiessling LL. Contrast agents for magnetic resonance imaging synthesized with ring-opening metathesis polymerization. Journal of the American Chemical Society. 128: 6534-5. PMID 16704234 DOI: 10.1021/ja061383p  1
2006 Raines RT. 2005 Emil Thomas Kaiser Award. Protein Science : a Publication of the Protein Society. 15: 1219-25. PMID 16641494 DOI: 10.1110/ps.062139406  1
2006 Eckenroth B, Harris K, Turanov AA, Gladyshev VN, Raines RT, Hondal RJ. Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry. 45: 5158-70. PMID 16618105 DOI: 10.1021/bi0517887  1
2006 Kotch FW, Raines RT. Self-assembly of synthetic collagen triple helices. Proceedings of the National Academy of Sciences of the United States of America. 103: 3028-33. PMID 16488977 DOI: 10.1073/pnas.0508783103  1
2006 Horng JC, Raines RT. Stereoelectronic effects on polyproline conformation. Protein Science : a Publication of the Protein Society. 15: 74-83. PMID 16373476 DOI: 10.1110/ps.051779806  1
2005 Lee JE, Raines RT. Cytotoxicity of bovine seminal ribonuclease: monomer versus dimer. Biochemistry. 44: 15760-7. PMID 16313179 DOI: 10.1021/bi051668z  1
2005 Hodges JA, Raines RT. Stereoelectronic and steric effects in the collagen triple helix: toward a code for strand association. Journal of the American Chemical Society. 127: 15923-32. PMID 16277536 DOI: 10.1021/ja054674r  1
2005 Rutkoski TJ, Kurten EL, Mitchell JC, Raines RT. Disruption of shape-complementarity markers to create cytotoxic variants of ribonuclease A. Journal of Molecular Biology. 354: 41-54. PMID 16188273 DOI: 10.1016/j.jmb.2005.08.007  1
2005 Dickson KA, Haigis MC, Raines RT. Ribonuclease inhibitor: structure and function. Progress in Nucleic Acid Research and Molecular Biology. 80: 349-74. PMID 16164979 DOI: 10.1016/S0079-6603(05)80009-1  1
2005 Kersteen EA, Barrows SR, Raines RT. Catalysis of protein disulfide bond isomerization in a homogeneous substrate. Biochemistry. 44: 12168-78. PMID 16142915 DOI: 10.1021/bi0507985  1
2005 Miller BG, Raines RT. Reconstitution of a defunct glycolytic pathway via recruitment of ambiguous sugar kinases. Biochemistry. 44: 10776-83. PMID 16086580 DOI: 10.1021/bi0506268  1
2005 Jenkins CL, Vasbinder MM, Miller SJ, Raines RT. Peptide bond isosteres: ester or (E)-alkene in the backbone of the collagen triple helix. Organic Letters. 7: 2619-22. PMID 15957905 DOI: 10.1021/ol050780m  1
2005 Fuchs SM, Raines RT. Polyarginine as a multifunctional fusion tag. Protein Science : a Publication of the Protein Society. 14: 1538-44. PMID 15930002 DOI: 10.1110/ps.051393805  1
2005 Nilsson BL, Soellner MB, Raines RT. Chemical synthesis of proteins. Annual Review of Biophysics and Biomolecular Structure. 34: 91-118. PMID 15869385 DOI: 10.1146/annurev.biophys.34.040204.144700  1
2005 Chandran SS, Dickson KA, Raines RT. Latent fluorophore based on the trimethyl lock. Journal of the American Chemical Society. 127: 1652-3. PMID 15700995 DOI: 10.1021/ja043736v  1
2005 Jenkins CL, Thiyagarajan N, Sweeney RY, Guy MP, Kelemen BR, Acharya KR, Raines RT. Binding of non-natural 3'-nucleotides to ribonuclease A. The Febs Journal. 272: 744-55. PMID 15670155 DOI: 10.1111/j.1742-4658.2004.04511.x  1
2005 Smith BD, Soellner MB, Raines RT. Synthetic surfaces for ribonuclease adsorption. Langmuir : the Acs Journal of Surfaces and Colloids. 21: 187-90. PMID 15620301 DOI: 10.1021/la0480686  1
2005 Jenkins CL, McCloskey AI, Guzei IA, Eberhardt ES, Raines RT. O-acylation of hydroxyproline residues: effect on peptide-bond isomerization and collagen stability. Biopolymers. 80: 1-8. PMID 15558658 DOI: 10.1002/bip.20164  1
2004 Jenkins CL, Lin G, Duo J, Rapolu D, Guzei IA, Raines RT, Krow GR. Substituted 2-azabicyclo[2.1.1]hexanes as constrained proline analogues: implications for collagen stability. The Journal of Organic Chemistry. 69: 8565-73. PMID 15575731 DOI: 10.1021/jo049242y  1
2004 Kersteen EA, Higgin JJ, Raines RT. Production of human prolyl 4-hydroxylase in Escherichia coli. Protein Expression and Purification. 38: 279-91. PMID 15555944 DOI: 10.1016/j.pep.2004.09.008  1
2004 Luk YY, Tingey ML, Dickson KA, Raines RT, Abbott NL. Imaging the binding ability of proteins immobilized on surfaces with different orientations by using liquid crystals. Journal of the American Chemical Society. 126: 9024-32. PMID 15264835 DOI: 10.1021/ja0398565  1
2004 Makarov AA, Yakovlev GI, Mitkevich VA, Higgin JJ, Raines RT. Zinc(II)-mediated inhibition of ribonuclease Sa by an N-hydroxyurea nucleotide and its basis. Biochemical and Biophysical Research Communications. 319: 152-6. PMID 15158454 DOI: 10.1016/j.bbrc.2004.04.182  1
2004 Miller BG, Raines RT. Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Biochemistry. 43: 6387-92. PMID 15157072 DOI: 10.1021/bi049424m  1
2004 Park SH, Raines RT. Fluorescence polarization assay to quantify protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 261: 161-6. PMID 15064456 DOI: 10.1385/1-59259-762-9:161  1
2004 Park SH, Raines RT. Fluorescence gel retardation assay to detect protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 261: 155-60. PMID 15064455 DOI: 10.1385/1-59259-762-9:155  1
2004 Fuchs SM, Raines RT. Pathway for polyarginine entry into mammalian cells. Biochemistry. 43: 2438-44. PMID 14992581 DOI: 10.1021/bi035933x  1
2004 Kim BM, Kim H, Raines RT, Lee Y. Glycosylation of onconase increases its conformational stability and toxicity for cancer cells. Biochemical and Biophysical Research Communications. 315: 976-83. PMID 14985108 DOI: 10.1016/j.bbrc.2004.01.153  1
2003 Matousek J, Soucek J, Slavík T, Tománek M, Lee JE, Raines RT. Comprehensive comparison of the cytotoxic activities of onconase and bovine seminal ribonuclease. Comparative Biochemistry and Physiology. Toxicology & Pharmacology : Cbp. 136: 343-56. PMID 15012906 DOI: 10.1016/j.cca.2003.10.005  1
2003 Lee JE, Raines RT. Contribution of active-site residues to the function of onconase, a ribonuclease with antitumoral activity. Biochemistry. 42: 11443-50. PMID 14516195 DOI: 10.1021/bi035147s  1
2003 Soellner MB, Dickson KA, Nilsson BL, Raines RT. Site-specific protein immobilization by Staudinger ligation. Journal of the American Chemical Society. 125: 11790-1. PMID 14505380 DOI: 10.1021/ja036712h  1
2003 Kersteen EA, Raines RT. Catalysis of protein folding by protein disulfide isomerase and small-molecule mimics. Antioxidants & Redox Signaling. 5: 413-24. PMID 13678529 DOI: 10.1089/152308603768295159  1
2003 Woycechowsky KJ, Hook BA, Raines RT. Catalysis of protein folding by an immobilized small-molecule dithiol. Biotechnology Progress. 19: 1307-14. PMID 12892495 DOI: 10.1021/bp0257123  1
2003 Hodges JA, Raines RT. Stereoelectronic effects on collagen stability: the dichotomy of 4-fluoroproline diastereomers. Journal of the American Chemical Society. 125: 9262-3. PMID 12889933 DOI: 10.1021/ja035881z  1
2003 Dickson KA, Dahlberg CL, Raines RT. Compensating effects on the cytotoxicity of ribonuclease A variants. Archives of Biochemistry and Biophysics. 415: 172-7. PMID 12831839 DOI: 10.1016/S0003-9861(03)00214-5  1
2003 Arnold U, Hinderaker MP, Köditz J, Golbik R, Ulbrich-Hofmann R, Raines RT. Protein prosthesis: a nonnatural residue accelerates folding and increases stability. Journal of the American Chemical Society. 125: 7500-1. PMID 12812474 DOI: 10.1021/ja0351239  1
2003 Jenkins CL, Bretscher LE, Guzei IA, Raines RT. Effect of 3-hydroxyproline residues on collagen stability. Journal of the American Chemical Society. 125: 6422-7. PMID 12785781 DOI: 10.1021/ja034015j  1
2003 Hinderaker MP, Raines RT. An electronic effect on protein structure. Protein Science : a Publication of the Protein Society. 12: 1188-94. PMID 12761389 DOI: 10.1110/ps.0241903  1
2003 Woycechowsky KJ, Raines RT. The CXC motif: a functional mimic of protein disulfide isomerase. Biochemistry. 42: 5387-94. PMID 12731880 DOI: 10.1021/bi026993q  1
2003 Nilsson BL, Hondal RJ, Soellner MB, Raines RT. Protein assembly by orthogonal chemical ligation methods. Journal of the American Chemical Society. 125: 5268-9. PMID 12720426 DOI: 10.1021/ja029752e  1
2003 Park C, Raines RT. Catalysis by ribonuclease A is limited by the rate of substrate association. Biochemistry. 42: 3509-18. PMID 12653555 DOI: 10.1021/bi026076k  1
2003 Smith BD, Soellner MB, Raines RT. Potent inhibition of ribonuclease A by oligo(vinylsulfonic acid). The Journal of Biological Chemistry. 278: 20934-8. PMID 12649287 DOI: 10.1074/jbc.M301852200  1
2003 Wright G, Higgin JJ, Raines RT, Steenbergen C, Murphy E. Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. The Journal of Biological Chemistry. 278: 20235-9. PMID 12649278 DOI: 10.1074/jbc.M301391200  1
2003 Higgin JJ, Yakovlev GI, Mitkevich VA, Makarov AA, Raines RT. Zinc(II)-mediated inhibition of a ribonuclease by an N-hydroxyurea nucleotide. Bioorganic & Medicinal Chemistry Letters. 13: 409-12. PMID 12565940 DOI: 10.1016/S0960-894X(02)00929-0  1
2003 Haigis MC, Kurten EL, Raines RT. Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Research. 31: 1024-32. PMID 12560499 DOI: 10.1093/nar/gkg163  1
2003 Plainkum P, Fuchs SM, Wiyakrutta S, Raines RT. Creation of a zymogen. Nature Structural Biology. 10: 115-9. PMID 12496934 DOI: 10.1038/nsb884  1
2003 Haigis MC, Raines RT. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. Journal of Cell Science. 116: 313-24. PMID 12482917 DOI: 10.1242/jcs.00214  1
2002 Arnold U, Hinderaker MP, Raines RT. Semisynthesis of ribonuclease A using intein-mediated protein ligation. Thescientificworldjournal. 2: 1823-7. PMID 12806173 DOI: 10.1100/tsw.2002.855  1
2002 Park SH, Raines RT. Genetic screen to dissect protein-protein interactions: ribonuclease inhibitor-ribonuclease A as a model system. Methods (San Diego, Calif.). 28: 346-52. PMID 12431438  1
2002 Sevcik J, Urbanikova L, Leland PA, Raines RT. X-ray structure of two crystalline forms of a streptomycete ribonuclease with cytotoxic activity. The Journal of Biological Chemistry. 277: 47325-30. PMID 12228255 DOI: 10.1074/jbc.M208425200  1
2002 Arnold U, Hinderaker MP, Nilsson BL, Huck BR, Gellman SH, Raines RT. Protein prosthesis: a semisynthetic enzyme with a beta-peptide reverse turn. Journal of the American Chemical Society. 124: 8522-3. PMID 12121081 DOI: 10.1021/ja026114n  1
2002 Soellner MB, Nilsson BL, Raines RT. Staudinger ligation of alpha-azido acids retains stereochemistry. The Journal of Organic Chemistry. 67: 4993-6. PMID 12098322 DOI: 10.1021/jo025631l  1
2002 Abel RL, Haigis MC, Park C, Raines RT. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Analytical Biochemistry. 306: 100-7. PMID 12069420 DOI: 10.1006/abio.2002.5678  1
2002 Haigis MC, Haag ES, Raines RT. Evolution of ribonuclease inhibitor by exon duplication. Molecular Biology and Evolution. 19: 959-63. PMID 12032252  1
2002 Jenkins CL, Raines RT. Insights on the conformational stability of collagen. Natural Product Reports. 19: 49-59. PMID 11902439 DOI: 10.1039/a903001h  1
2002 Hondal RJ, Raines RT. Semisynthesis of proteins containing selenocysteine. Methods in Enzymology. 347: 70-83. PMID 11898440 DOI: 10.1016/S0076-6879(02)47009-7  1
2002 DeRider ML, Wilkens SJ, Waddell MJ, Bretscher LE, Weinhold F, Raines RT, Markley JL. Collagen stability: insights from NMR spectroscopic and hybrid density functional computational investigations of the effect of electronegative substituents on prolyl ring conformations. Journal of the American Chemical Society. 124: 2497-505. PMID 11890798 DOI: 10.1021/ja0166904  1
2002 Leland PA, Staniszewski KE, Park C, Kelemen BR, Raines RT. The ribonucleolytic activity of angiogenin. Biochemistry. 41: 1343-50. PMID 11802736 DOI: 10.1021/bi0117899  1
2002 Haigis MC, Kurten EL, Abel RL, Raines RT. KFERQ sequence in ribonuclease A-mediated cytotoxicity. The Journal of Biological Chemistry. 277: 11576-81. PMID 11801605 DOI: 10.1074/jbc.M112227200  1
2002 Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SH. Translocation of a beta-peptide across cell membranes. Journal of the American Chemical Society. 124: 368-9. PMID 11792194 DOI: 10.1021/ja017283v  1
2001 Arnold U, Hinderaker MP, Raines RT. Semisynthesis of Protein variants Using Intein-Mediated Protein Ligation. Thescientificworldjournal. 1: 117. PMID 30147597 DOI: 10.1100/tsw.2001.215  1
2001 Park C, Raines RT. Adjacent cysteine residues as a redox switch. Protein Engineering. 14: 939-42. PMID 11742114  1
2001 Park C, Raines RT. Quantitative analysis of the effect of salt concentration on enzymatic catalysis. Journal of the American Chemical Society. 123: 11472-9. PMID 11707126 DOI: 10.1021/ja0164834  1
2001 Park C, Kelemen BR, Klink TA, Sweeney RY, Behlke MA, Eubanks SR, Raines RT. Fast, facile, hypersensitive assays for ribonucleolytic activity. Methods in Enzymology. 341: 81-94. PMID 11582813 DOI: 10.1016/S0076-6879(01)41146-3  1
2001 Leland PA, Staniszewski KE, Kim BM, Raines RT. Endowing human pancreatic ribonuclease with toxicity for cancer cells. The Journal of Biological Chemistry. 276: 43095-102. PMID 11555655 DOI: 10.1074/jbc.M106636200  1
2001 Jardine AM, Leonidas DD, Jenkins JL, Park C, Raines RT, Acharya KR, Shapiro R. Cleavage of 3',5'-pyrophosphate-linked dinucleotides by ribonuclease A and angiogenin. Biochemistry. 40: 10262-72. PMID 11513604 DOI: 10.1021/bi010888j  1
2001 Hondal RJ, Nilsson BL, Raines RT. Selenocysteine in native chemical ligation and expressed protein ligation. Journal of the American Chemical Society. 123: 5140-1. PMID 11457362 DOI: 10.1021/ja005885t  1
2001 Bretscher LE, Jenkins CL, Taylor KM, DeRider ML, Raines RT. Conformational stability of collagen relies on a stereoelectronic effect. Journal of the American Chemical Society. 123: 777-8. PMID 11456609 DOI: 10.1021/ja005542v  1
2001 Klink TA, Vicentini AM, Hofsteenge J, Raines RT. High-level soluble production and characterization of porcine ribonuclease inhibitor. Protein Expression and Purification. 22: 174-9. PMID 11437592 DOI: 10.1006/prep.2001.1422  1
2001 Nilsson BL, Kiessling LL, Raines RT. High-yielding Staudinger ligation of a phosphinothioester and azide to form a peptide. Organic Letters. 3: 9-12. PMID 11429880 DOI: 10.1021/ol006739v  1
2001 Leland PA, Raines RT. Cancer chemotherapy--ribonucleases to the rescue. Chemistry & Biology. 8: 405-13. PMID 11358688 DOI: 10.1016/S1074-5521(01)00030-8  1
2001 Kersteen EA, Raines RT. Contribution of tertiary amides to the conformational stability of collagen triple helices. Biopolymers. 59: 24-8. PMID 11343277 DOI: 10.1002/1097-0282(200107)59:1<24::AID-BIP1002>3.0.CO;2-N  1
2001 Park C, Schultz LW, Raines RT. Contribution of the active site histidine residues of ribonuclease A to nucleic acid binding. Biochemistry. 40: 4949-56. PMID 11305910 DOI: 10.1021/bi0100182  1
2000 Messmore JM, Raines RT. Pentavalent Organo-Vanadates as Transition State Analogues for Phosphoryl Transfer Reactions. Journal of the American Chemical Society. 122: 9911-9916. PMID 21423825 DOI: 10.1021/ja0021058  1
2000 Park C, Raines RT. Dimer formation by a "monomeric" protein. Protein Science : a Publication of the Protein Society. 9: 2026-33. PMID 11106177 DOI: 10.1110/ps.9.10.2026  1
2000 Kelemen BR, Schultz LW, Sweeney RY, Raines RT. Excavating an active site: the nucleobase specificity of ribonuclease A. Biochemistry. 39: 14487-94. PMID 11087402 DOI: 10.1021/bi001862f  1
2000 Park SH, Raines RT. Green fluorescent protein chimeras to probe protein-protein interactions. Methods in Enzymology. 328: 251-61. PMID 11075349  1
2000 Sweeney RY, Kelemen BR, Woycechowsky KJ, Raines RT. A highly active immobilized ribonuclease. Analytical Biochemistry. 286: 312-4. PMID 11067760 DOI: 10.1006/abio.2000.4820  1
2000 Messmore JM, Raines RT. Decavanadate inhibits catalysis by ribonuclease A. Archives of Biochemistry and Biophysics. 381: 25-30. PMID 11019816 DOI: 10.1006/abbi.2000.1951  1
2000 Ruoppolo M, Vinci F, Klink TA, Raines RT, Marino G. Contribution of individual disulfide bonds to the oxidative folding of ribonuclease A. Biochemistry. 39: 12033-42. PMID 11009618 DOI: 10.1021/bi001044n  1
2000 Woycechowsky KJ, Raines RT. Native disulfide bond formation in proteins. Current Opinion in Chemical Biology. 4: 533-9. PMID 11006541 DOI: 10.1016/S1367-5931(00)00128-9  1
2000 Park SH, Raines RT. Genetic selection for dissociative inhibitors of designated protein-protein interactions. Nature Biotechnology. 18: 847-51. PMID 10932153 DOI: 10.1038/78451  1
2000 Leland PA, Staniszewski KE, Kim B, Raines RT. A synapomorphic disulfide bond is critical for the conformational stability and cytotoxicity of an amphibian ribonuclease. Febs Letters. 477: 203-7. PMID 10908721 DOI: 10.1016/S0014-5793(00)01804-4  1
2000 Nilsson BL, Kiessling LL, Raines RT. Staudinger ligation: a peptide from a thioester and azide. Organic Letters. 2: 1939-41. PMID 10891196  1
2000 Messmore JM, Holmgren SK, Grilley JE, Raines RT. Sulfur shuffle: modulating enzymatic activity by thiol-disulfide interchange. Bioconjugate Chemistry. 11: 408-13. PMID 10821658 DOI: 10.1021/bc990142m  1
2000 Friedman L, Higgin JJ, Moulder G, Barstead R, Raines RT, Kimble J. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. 97: 4736-41. PMID 10781079 DOI: 10.1073/pnas.97.9.4736  1
2000 Klink TA, Raines RT. Conformational stability is a determinant of ribonuclease A cytotoxicity. The Journal of Biological Chemistry. 275: 17463-7. PMID 10747991 DOI: 10.1074/jbc.M001132200  1
2000 Bretscher LE, Abel RL, Raines RT. A ribonuclease A variant with low catalytic activity but high cytotoxicity. The Journal of Biological Chemistry. 275: 9893-6. PMID 10744660 DOI: 10.1074/jbc.275.14.9893  1
2000 Park C, Raines RT. Origin of the 'inactivation' of ribonuclease A at low salt concentration. Febs Letters. 468: 199-202. PMID 10692586 DOI: 10.1016/S0014-5793(00)01227-8  1
2000 Klink TA, Woycechowsky KJ, Taylor KM, Raines RT. Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A. European Journal of Biochemistry / Febs. 267: 566-72. PMID 10632727 DOI: 10.1046/j.1432-1327.2000.01037.x  1
1999 Woycechowsky KJ, Wittrup KD, Raines RT. A small-molecule catalyst of protein folding in vitro and in vivo. Chemistry & Biology. 6: 871-9. PMID 10631515 DOI: 10.1016/S1074-5521(00)80006-X  1
1999 Mannino SJ, Jenkins CL, Raines RT. Chemical mechanism of DNA cleavage by the homing endonuclease I-PpoI. Biochemistry. 38: 16178-86. PMID 10587440 DOI: 10.1021/bi991452v  1
1999 Schultz LW, Chivers PT, Raines RT. The CXXC motif: crystal structure of an active-site variant of Escherichia coli thioredoxin. Acta Crystallographica. Section D, Biological Crystallography. 55: 1533-8. PMID 10489448 DOI: 10.1107/S0907444999008756  1
1999 Kelemen BR, Klink TA, Behlke MA, Eubanks SR, Leland PA, Raines RT. Hypersensitive substrate for ribonucleases. Nucleic Acids Research. 27: 3696-701. PMID 10471739 DOI: 10.1093/nar/27.18.3696  1
1999 Kelemen BR, Raines RT. Extending the limits to enzymatic catalysis: diffusion of ribonuclease A in one dimension. Biochemistry. 38: 5302-7. PMID 10220316 DOI: 10.1021/bi990325w  1
1999 Quirk DJ, Raines RT. His ... Asp catalytic dyad of ribonuclease A: histidine pKa values in the wild-type, D121N, and D121A enzymes. Biophysical Journal. 76: 1571-9. PMID 10049337 DOI: 10.1016/S0006-3495(99)77316-9  1
1999 Kim BM, Schultz LW, Raines RT. Variants of ribonuclease inhibitor that resist oxidation. Protein Science : a Publication of the Protein Society. 8: 430-4. PMID 10048337 DOI: 10.1110/ps.8.2.430  1
1999 Holmgren SK, Bretscher LE, Taylor KM, Raines RT. A hyperstable collagen mimic. Chemistry & Biology. 6: 63-70. PMID 10021421 DOI: 10.1016/S1074-5521(99)80003-9  1
1998 Quirk DJ, Park C, Thompson JE, Raines RT. His...Asp catalytic dyad of ribonuclease A: conformational stability of the wild-type, D121N, D121A, and H119A enzymes. Biochemistry. 37: 17958-64. PMID 9922164 DOI: 10.1021/bi981688j  1
1998 Fisher BM, Schultz LW, Raines RT. Coulombic effects of remote subsites on the active site of ribonuclease A. Biochemistry. 37: 17386-401. PMID 9860854 DOI: 10.1021/bi981369s  1
1998 Leland PA, Schultz LW, Kim BM, Raines RT. Ribonuclease A variants with potent cytotoxic activity. Proceedings of the National Academy of Sciences of the United States of America. 95: 10407-12. PMID 9724716 DOI: 10.1073/pnas.95.18.10407  1
1998 Fisher BM, Ha JH, Raines RT. Coulombic forces in protein-RNA interactions: binding and cleavage by ribonuclease A and variants at Lys7, Arg10, and Lys66. Biochemistry. 37: 12121-32. PMID 9724524 DOI: 10.1021/bi980743l  1
1998 Schultz LW, Hargraves SR, Klink TA, Raines RT. Structure and stability of the P93G variant of ribonuclease A. Protein Science : a Publication of the Protein Society. 7: 1620-5. PMID 9684895 DOI: 10.1002/pro.5560070716  1
1998 Schultz LW, Quirk DJ, Raines RT. His...Asp catalytic dyad of ribonuclease A: structure and function of the wild-type, D121N, and D121A enzymes. Biochemistry. 37: 8886-98. PMID 9636030 DOI: 10.1021/bi972766q  1
1998 Holmgren SK, Taylor KM, Bretscher LE, Raines RT. Code for collagen's stability deciphered. Nature. 392: 666-7. PMID 9565027 DOI: 10.1038/33573  1
1998 Wittmayer PK, McKenzie JL, Raines RT. Degenerate DNA recognition by I-PpoI endonuclease. Gene. 206: 11-21. PMID 9461409 DOI: 10.1016/S0378-1119(97)00563-5  1
1997 Matoušek J, Kim JS, Souček J, Rìha J, Ribó M, Leland PA, Raines RT. Ribonucleases endowed with specific toxicity for spermatogenic layers. Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118: 881-888. PMID 21399757 DOI: 10.1016/S0305-0491(97)00278-2  1
1997 Chivers PT, Raines RT. General acid/base catalysis in the active site of Escherichia coli thioredoxin. Biochemistry. 36: 15810-6. PMID 9398311 DOI: 10.1021/bi971504l  1
1997 Chivers PT, Prehoda KE, Volkman BF, Kim BM, Markley JL, Raines RT. Microscopic pKa values of Escherichia coli thioredoxin. Biochemistry. 36: 14985-91. PMID 9398223 DOI: 10.1021/bi970071j  1
1997 Park SH, Raines RT. Green fluorescent protein as a signal for protein-protein interactions. Protein Science : a Publication of the Protein Society. 6: 2344-9. PMID 9385636 DOI: 10.1002/pro.5560061107  1
1997 Laboissière MC, Sturley SL, Raines RT. Protein disulfide isomerase in spore germination and cell division. Biological Chemistry. 378: 431-7. PMID 9191030  1
1997 Chivers PT, Prehoda KE, Raines RT. The CXXC motif: a rheostat in the active site. Biochemistry. 36: 4061-6. PMID 9099998 DOI: 10.1021/bi9628580  1
1996 Eberhardt ES, Panisik N, Raines RT. Inductive Effects on the Energetics of Prolyl Peptide Bond Isomerization: Implications for Collagen Folding and Stability. Journal of the American Chemical Society. 118: 12261-12266. PMID 21451735 DOI: 10.1021/ja9623119  1
1996 Ribó M, delCardayré SB, Raines RT, de Llorens R, Cuchillo CM. Production of human pancreatic ribonuclease in Saccharomyces cerevisiae and Escherichia coli. Protein Expression and Purification. 7: 253-61. PMID 8860650 DOI: 10.1006/prep.1996.0036  1
1996 Eberhardt ES, Wittmayer PK, Templer BM, Raines RT. Contribution of a tyrosine side chain to ribonuclease A catalysis and stability. Protein Science : a Publication of the Protein Society. 5: 1697-703. PMID 8844858 DOI: 10.1002/pro.5560050823  1
1996 Chivers PT, Laboissière MC, Raines RT. The CXXC motif: imperatives for the formation of native disulfide bonds in the cell. The Embo Journal. 15: 2659-67. PMID 8654363  1
1996 Wittmayer PK, Raines RT. Substrate binding and turnover by the highly specific I-PpoI endonuclease. Biochemistry. 35: 1076-83. PMID 8547243 DOI: 10.1021/bi952363v  1
1995 Thompson JE, Kutateladze TG, Schuster MC, Venegas FD, Messmore JM, Raines RT. Limits to Catalysis by Ribonuclease A. Bioorganic Chemistry. 23: 471-481. PMID 21799547 DOI: 10.1006/bioo.1995.1033  1
1995 Messmore JM, Fuchs DN, Raines RT. Ribonuclease a: revealing structure-function relationships with semisynthesis. Journal of the American Chemical Society. 117: 8057-60. PMID 21732653 DOI: 10.1021/ja00136a001  1
1995 Kim JS, Soucek J, Matousek J, Raines RT. Mechanism of ribonuclease cytotoxicity. The Journal of Biological Chemistry. 270: 31097-102. PMID 8537370  1
1995 Laboissière MC, Chivers PT, Raines RT. Production of rat protein disulfide isomerase in Saccharomyces cerevisiae. Protein Expression and Purification. 6: 700-6. PMID 8535165 DOI: 10.1006/prep.1995.1092  1
1995 Kim JS, Raines RT. Dibromobimane as a fluorescent crosslinking reagent. Analytical Biochemistry. 225: 174-6. PMID 7778775 DOI: 10.1006/abio.1995.1131  1
1995 Kim JS, Soucek J, Matousek J, Raines RT. Catalytic activity of bovine seminal ribonuclease is essential for its immunosuppressive and other biological activities. The Biochemical Journal. 308: 547-50. PMID 7772040  1
1995 Kim JS, Soucek J, Matousek J, Raines RT. Structural basis for the biological activities of bovine seminal ribonuclease. The Journal of Biological Chemistry. 270: 10525-30. PMID 7737987  1
1995 Raines RT, Toscano MP, Nierengarten DM, Ha JH, Auerbach R. Replacing a surface loop endows ribonuclease A with angiogenic activity. The Journal of Biological Chemistry. 270: 17180-4. PMID 7615514 DOI: 10.1074/jbc.270.29.17180  1
1995 delCardayré SB, Raines RT. A residue to residue hydrogen bond mediates the nucleotide specificity of ribonuclease A. Journal of Molecular Biology. 252: 328-36. PMID 7563054 DOI: 10.1006/jmbi.1995.0500  1
1995 delCardayré SB, Raines RT. The extent to which ribonucleases cleave ribonucleic acid. Analytical Biochemistry. 225: 176-8. PMID 7539983 DOI: 10.1006/abio.1995.1132  1
1995 Laboissiere MC, Sturley SL, Raines RT. The essential function of protein-disulfide isomerase is to unscramble non-native disulfide bonds. The Journal of Biological Chemistry. 270: 28006-9. PMID 7499282  1
1995 delCardayré SB, Ribó M, Yokel EM, Quirk DJ, Rutter WJ, Raines RT. Engineering ribonuclease A: production, purification and characterization of wild-type enzyme and mutants at Gln11. Protein Engineering. 8: 261-73. PMID 7479688 DOI: 10.1093/protein/8.3.261  1
1994 Eberhardt ES, Raines RT. Amide-Amide and Amide-Water Hydrogen Bonds: Implications for Protein Folding and Stability. Journal of the American Chemical Society. 116: 2149-2150. PMID 21552509  1
1994 Thompson JE, Raines RT. Value of general Acid-base catalysis to ribonuclease a. Journal of the American Chemical Society. 116: 5467-8. PMID 21391696 DOI: 10.1021/ja00091a060  1
1994 delCardayré SB, Raines RT. Structural determinants of enzymatic processivity. Biochemistry. 33: 6031-7. PMID 8193116  1
1994 Kim JS, Raines RT. A misfolded but active dimer of bovine seminal ribonuclease. European Journal of Biochemistry / Febs. 224: 109-14. PMID 8076630  1
1994 Kim JS, Raines RT. Peptide tags for a dual affinity fusion system. Analytical Biochemistry. 219: 165-6. PMID 8059949 DOI: 10.1006/abio.1994.1251  1
1994 Thompson JE, Venegas FD, Raines RT. Energetics of catalysis by ribonucleases: fate of the 2',3'-cyclic phosphodiester intermediate. Biochemistry. 33: 7408-14. PMID 8003506  1
1994 Panasik N, Eberhardt ES, Edison AS, Powell DR, Raines RT. Inductive effects on the structure of proline residues International Journal of Peptide and Protein Research. 44: 262-269. PMID 7822103  1
1993 Eberhardt ES, Loh SN, Raines RT. Thermodynamic Origin of Prolyl Peptide Bond Isomers. Tetrahedron Letters. 34: 3055-3056. PMID 20628473 DOI: 10.1016/S0040-4039(00)93377-X  1
1993 Taylor CB, Bariola PA, delCardayré SB, Raines RT, Green PJ. RNS2: a senescence-associated RNase of Arabidopsis that diverged from the S-RNases before speciation. Proceedings of the National Academy of Sciences of the United States of America. 90: 5118-22. PMID 8506358  1
1993 Kim JS, Raines RT. Ribonuclease S-peptide as a carrier in fusion proteins. Protein Science : a Publication of the Protein Society. 2: 348-56. PMID 8453373 DOI: 10.1002/pro.5560020307  1
1993 Kim JS, Raines RT. Bovine seminal ribonuclease produced from a synthetic gene. The Journal of Biological Chemistry. 268: 17392-6. PMID 7688724  1
1992 Eberhardt ES, Loh SN, Hinck AP, Raines RT. Solvent Effects on the Energetics of Prolyl Peptide Bond Isomerization. Journal of the American Chemical Society. 114: 5437-5439. PMID 21451730  1
1989 Burbaum JJ, Raines RT, Albery WJ, Knowles JR. Evolutionary optimization of the catalytic effectiveness of an enzyme. Biochemistry. 28: 9293-305. PMID 2611230  1
1988 Blacklow SC, Raines RT, Lim WA, Zamore PD, Knowles JR. Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. Biochemistry. 27: 1158-67. PMID 3365378  1
1987 Raines RT, Knowles JR. Enzyme relaxation in the reaction catalyzed by triosephosphate isomerase: detection and kinetic characterization of two unliganded forms of the enzyme. Biochemistry. 26: 7014-20. PMID 3427057  1
1986 Raines RT, Knowles JR. The mechanistic pathway of a mutant triosephosphate isomerase. Annals of the New York Academy of Sciences. 471: 266-71. PMID 3460499  1
1986 Raines RT, Sutton EL, Straus DR, Gilbert W, Knowles JR. Reaction energetics of a mutant triosephosphate isomerase in which the active-site glutamate has been changed to aspartate. Biochemistry. 25: 7142-54. PMID 2879556  1
Show low-probability matches.