Alexander V. Mayorov, Ph.D. - Publications

Affiliations: 
1996-2001 Chemistry University of Louisville, Louisville, KY, United States 
Area:
Organic Chemistry, Pharmaceutical Chemistry

33 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Jalah R, Torres OB, Mayorov AV, Li F, Antoline JF, Jacobson AE, Rice KC, Deschamps JR, Beck Z, Alving CR, Matyas GR. Efficacy, but Not Antibody Titer or Affinity, of a Heroin Hapten Conjugate Vaccine Correlates with Increasing Hapten Densities on Tetanus Toxoid, but Not on CRM197 Carriers. Bioconjugate Chemistry. 26: 1041-53. PMID 25970207 DOI: 10.1021/acs.bioconjchem.5b00085  1
2014 Matyas GR, Rice KC, Cheng K, Li F, Antoline JF, Iyer MR, Jacobson AE, Mayorov AV, Beck Z, Torres OB, Alving CR. Facial recognition of heroin vaccine opiates: type 1 cross-reactivities of antibodies induced by hydrolytically stable haptenic surrogates of heroin, 6-acetylmorphine, and morphine. Vaccine. 32: 1473-9. PMID 24486371 DOI: 10.1016/j.vaccine.2014.01.028  1
2013 Matyas GR, Mayorov AV, Rice KC, Jacobson AE, Cheng K, Iyer MR, Li F, Beck Z, Janda KD, Alving CR. Liposomes containing monophosphoryl lipid A: a potent adjuvant system for inducing antibodies to heroin hapten analogs. Vaccine. 31: 2804-10. PMID 23624097 DOI: 10.1016/j.vaccine.2013.04.027  1
2012 Alving CR, Rao M, Steers NJ, Matyas GR, Mayorov AV. Liposomes containing lipid A: an effective, safe, generic adjuvant system for synthetic vaccines. Expert Review of Vaccines. 11: 733-44. PMID 22873129 DOI: 10.1586/erv.12.35  1
2012 Zakhari JS, Zorrilla EP, Zhou B, Mayorov AV, Janda KD. Oligoclonal antibody targeting ghrelin increases energy expenditure and reduces food intake in fasted mice. Molecular Pharmaceutics. 9: 281-9. PMID 22149064 DOI: 10.1021/mp200376c  1
2011 Eubanks LM, Stowe GN, De Lamo Marin S, Mayorov AV, Hixon MS, Janda KD. Identification of α2 macroglobulin as a major serum ghrelin esterase. Angewandte Chemie (International Ed. in English). 50: 10699-702. PMID 21928452 DOI: 10.1002/anie.201104512  1
2011 Stowe GN, Vendruscolo LF, Edwards S, Schlosburg JE, Misra KK, Schulteis G, Mayorov AV, Zakhari JS, Koob GF, Janda KD. A vaccine strategy that induces protective immunity against heroin. Journal of Medicinal Chemistry. 54: 5195-204. PMID 21692508 DOI: 10.1021/jm200461m  1
2011 Mayorov AV, Cai M, Palmer ES, Tanaka DK, Cain JP, Dedek MM, Tan B, Trivedi D, Hruby VJ. Cyclic lactam hybrid α-MSH/Agouti-related protein (AGRP) analogues with nanomolar range binding affinities at the human melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 21: 3099-102. PMID 21486697 DOI: 10.1016/j.bmcl.2011.03.019  1
2011 Moreno AY, Mayorov AV, Janda KD. Impact of distinct chemical structures for the development of a methamphetamine vaccine. Journal of the American Chemical Society. 133: 6587-95. PMID 21473576 DOI: 10.1021/ja108807j  1
2011 Garner AL, Yu J, Struss AK, Lowery CA, Zhu J, Kim SK, Park J, Mayorov AV, Kaufmann GF, Kravchenko VV, Janda KD. Synthesis of 'clickable' acylhomoserine lactone quorum sensing probes: unanticipated effects on mammalian cell activation. Bioorganic & Medicinal Chemistry Letters. 21: 2702-5. PMID 21190852 DOI: 10.1016/j.bmcl.2010.11.122  1
2011 Kaufmann GF, Park J, Mayorov AV, Kubitz DM, Janda KD. Generation of quorum quenching antibodies. Methods in Molecular Biology (Clifton, N.J.). 692: 299-311. PMID 21031321 DOI: 10.1007/978-1-60761-971-0_22  1
2010 Mayorov AV, Willis B, Di Mola A, Adler D, Borgia J, Jackson O, Wang J, Luo Y, Tang L, Knapp RJ, Natarajan C, Goodnough MC, Zilberberg N, Simpson LL, Janda KD. Symptomatic relief of botulinum neurotoxin/a intoxication with aminopyridines: a new twist on an old molecule. Acs Chemical Biology. 5: 1183-91. PMID 20936877 DOI: 10.1021/cb1002366  1
2010 Mayorov AV, Cai M, Palmer ES, Liu Z, Cain JP, Vagner J, Trivedi D, Hruby VJ. Solid-phase peptide head-to-side chain cyclodimerization: discovery of C(2)-symmetric cyclic lactam hybrid α-melanocyte-stimulating hormone (MSH)/agouti-signaling protein (ASIP) analogues with potent activities at the human melanocortin receptors. Peptides. 31: 1894-905. PMID 20688117 DOI: 10.1016/j.peptides.2010.06.026  1
2009 Qu H, Cai M, Mayorov AV, Grieco P, Zingsheim M, Trivedi D, Hruby VJ. Substitution of arginine with proline and proline derivatives in melanocyte-stimulating hormones leads to selectivity for human melanocortin 4 receptor. Journal of Medicinal Chemistry. 52: 3627-35. PMID 19473029 DOI: 10.1021/jm801300c  1
2009 Min BJ, Mayorov AV, Cai M, Palmer E, Hruby VJ. Design and parallel synthesis of new bicyclic small molecules for targeting the melanocortin receptors. Advances in Experimental Medicine and Biology. 611: 187-8. PMID 19400153 DOI: 10.1007/978-0-387-73657-0_86  1
2008 Mayorov AV, Amara N, Chang JY, Moss JA, Hixon MS, Ruiz DI, Meijler MM, Zorrilla EP, Janda KD. Catalytic antibody degradation of ghrelin increases whole-body metabolic rate and reduces refeeding in fasting mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 17487-92. PMID 18981425 DOI: 10.1073/pnas.0711808105  1
2008 Treweek JB, Sun C, Mayorov AV, Qi L, Levy CL, Roberts AJ, Dickerson TJ, Janda KD. Prevention of drug-induced memory impairment by immunopharmacotherapy. Journal of Medicinal Chemistry. 51: 6866-75. PMID 18921991 DOI: 10.1021/jm800506v  1
2008 Mayorov AV, Cai M, Palmer ES, Dedek MM, Cain JP, Van Scoy AR, Tan B, Vagner J, Trivedi D, Hruby VJ. Structure-activity relationships of cyclic lactam analogues of alpha-melanocyte-stimulating hormone (alpha-MSH) targeting the human melanocortin-3 receptor. Journal of Medicinal Chemistry. 51: 187-95. PMID 18088090 DOI: 10.1021/jm070461w  1
2007 King SH, Mayorov AV, Balse-Srinivasan P, Hruby VJ, Vanderah TW, Wessells H. Melanocortin receptors, melanotropic peptides and penile erection. Current Topics in Medicinal Chemistry. 7: 1098-1106. PMID 17584130  1
2007 Hruby VJ, Cai M, Cain JP, Mayorov AV, Dedek MM, Trivedi D. Design, synthesis and biological evaluation of ligands selective for the melanocortin-3 receptor. Current Topics in Medicinal Chemistry. 7: 1107-19. PMID 17584128 DOI: 10.2174/156802607780906654  1
2007 Ballet S, Mayorov AV, Cai M, Tymecka D, Chandler KB, Palmer ES, Rompaey KV, Misicka A, Tourwé D, Hruby VJ. Novel selective human melanocortin-3 receptor ligands: use of the 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one (Aba) scaffold. Bioorganic & Medicinal Chemistry Letters. 17: 2492-8. PMID 17314042 DOI: 10.1016/j.bmcl.2007.02.020  1
2006 Cain JP, Mayorov AV, Cai M, Wang H, Tan B, Chandler K, Lee Y, Petrov RR, Trivedi D, Hruby VJ. Design, synthesis, and biological evaluation of a new class of small molecule peptide mimetics targeting the melanocortin receptors. Bioorganic & Medicinal Chemistry Letters. 16: 5462-7. PMID 16931008 DOI: 10.1016/j.bmcl.2006.07.015  1
2006 Mayorov AV, Han SY, Cai M, Hammer MR, Trivedi D, Hruby VJ. Effects of macrocycle size and rigidity on melanocortin receptor-1 and -5 selectivity in cyclic lactam alpha-melanocyte-stimulating hormone analogs. Chemical Biology & Drug Design. 67: 329-35. PMID 16784457 DOI: 10.1111/j.1747-0285.2006.00383.x  1
2006 Mayorov AV, Cai M, Chandler KB, Petrov RR, Van Scoy AR, Yu Z, Tanaka DK, Trivedi D, Hruby VJ. Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. Journal of Medicinal Chemistry. 49: 1946-52. PMID 16539382 DOI: 10.1021/jm0510326  1
2006 Grieco P, Cai M, Mayorov AV, Trivedi D, Hruby VJ. Structure-activity studies of new melanocortin peptides containing an aromatic amino acid at the N-terminal position. Peptides. 27: 472-81. PMID 16303211 DOI: 10.1016/j.peptides.2005.01.032  1
2005 Cai M, Mayorov AV, Ying J, Stankova M, Trivedi D, Cabello C, Hruby VJ. Design of novel melanotropin agonists and antagonists with high potency and selectivity for human melanocortin receptors. Peptides. 26: 1481-5. PMID 15876475 DOI: 10.1016/j.peptides.2005.03.020  1
2005 Cai M, Mayorov AV, Cabello C, Stankova M, Trivedi D, Hruby VJ. Novel 3D pharmacophore of alpha-MSH/gamma-MSH hybrids leads to selective human MC1R and MC3R analogues. Journal of Medicinal Chemistry. 48: 1839-48. PMID 15771429 DOI: 10.1021/jm049579s  1
2004 Cai M, Stankova M, Pond SJ, Mayorov AV, Perry JW, Yamamura HI, Trivedi D, Hruby VJ. Real time differentiation of G-protein coupled receptor (GPCR) agonist and antagonist by two photon fluorescence laser microscopy. Journal of the American Chemical Society. 126: 7160-1. PMID 15186137 DOI: 10.1021/ja049473m  1
2004 Cai M, Cai C, Mayorov AV, Xiong C, Cabello CM, Soloshonok VA, Swift JR, Trivedi D, Hruby VJ. Biological and conformational study of beta-substituted prolines in MT-II template: steric effects leading to human MC5 receptor selectivity. The Journal of Peptide Research : Official Journal of the American Peptide Society. 63: 116-31. PMID 15009533 DOI: 10.1111/j.1399-3011.2003.00105.x  1
2003 Luzzio FA, Mayorov AV, Ng SS, Kruger EA, Figg WD. Thalidomide metabolites and analogues. 3. Synthesis and antiangiogenic activity of the teratogenic and TNFalpha-modulatory thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine. Journal of Medicinal Chemistry. 46: 3793-9. PMID 12930142 DOI: 10.1021/jm020079d  1
2003 Luzzio FA, Mayorov AV. Palladium(0)-mediated preparation of trans-4-substituted-1- (phthalimido)-2-cyclopentenes Synlett. 532-536. DOI: 10.1002/CHIN.200329170  1
2000 Luzzio FA, Mayorov AV, Figg WD. Thalidomide metabolites. Part 1: Derivatives of (+)-2-(N-phthalimido)- γ-hydroxyglutamic acid Tetrahedron Letters. 41: 2275-2278. DOI: 10.1016/S0040-4039(00)00160-X  1
1999 Luzzio FA, Mayorov AV, Menes ME, Champion WL. Asymmetric synthesis of 4'-methyl-2',3'-dideoxynucleosides Nucleosides and Nucleotides. 18: 1977-1984.  1
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