Robert L. Wykle - Publications

Affiliations: 
Wake Forest University School of Medicine, Winston-Salem, NC, United States 
Area:
Biochemistry, Cell Biology, Oncology

72 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2007 Owen JS, Thomas MJ, Wykle RL. Platelet-activating factor. Methods in Enzymology. 434: 105-16. PMID 17954244 DOI: 10.1016/S0076-6879(07)34006-8  0.493
2005 Owen JS, Baker PR, O'Flaherty JT, Thomas MJ, Samuel MP, Wooten RE, Wykle RL. Stress-induced platelet-activating factor synthesis in human neutrophils. Biochimica Et Biophysica Acta. 1733: 120-9. PMID 15863359 DOI: 10.1016/J.Bbalip.2004.12.016  0.542
2005 Owen JS, Wykle RL, Samuel MP, Thomas MJ. An improved assay for platelet-activating factor using HPLC-tandem mass spectrometry. Journal of Lipid Research. 46: 373-82. PMID 15520455 DOI: 10.1194/Jlr.D400029-Jlr200  0.484
2002 Baker PR, Owen JS, Nixon AB, Thomas L, Wooten R, Daniel LW, O'Flaherty JT, Wykle RL. Regulation of platelet-activating factor synthesis in human neutrophils by MAP kinases. Biochimica Et Biophysica Acta. 1592: 175-84. PMID 12379481 DOI: 10.1016/S0167-4889(02)00314-2  0.575
2002 Snyder F, Lee Tc, Wykle RL. Chapter 9 Ether-linked lipids and their bioactive species New Comprehensive Biochemistry. 36: 233-262. DOI: 10.1016/S0167-7306(02)36011-3  0.306
1999 Nixon AB, O'Flaherty JT, Salyer JK, Wykle RL. Acetyl-CoA:1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine acetyltransferase is directly activated by p38 kinase Journal of Biological Chemistry. 274: 5469-5473. PMID 10026159 DOI: 10.1074/Jbc.274.9.5469  0.398
1998 Seeds MC, Nixon AB, Wykle RL, Bass DA. Differential activation of human neutrophil cytosolic phospholipase A2 and secretory phospholipase A2 during priming by 1,2-diacyl- and 1-O-alkyl-2-acylglycerols Biochimica Et Biophysica Acta - Lipids and Lipid Metabolism. 1394: 224-234. PMID 9795228 DOI: 10.1016/S0005-2760(98)00111-8  0.443
1997 Nixon AB, Seeds MC, Bass DA, Smitherman PK, O'Flaherty JT, Daniel LW, Wykle RL. Comparison of alkylacylglycerol vs. diacylglycerol as activators of mitogen-activated protein kinase and cytosolic phospholipase A2 in human neutrophil priming Biochimica Et Biophysica Acta - Lipids and Lipid Metabolism. 1347: 219-230. PMID 9295167 DOI: 10.1016/S0005-2760(97)00077-5  0.397
1997 Wykle RL, Wijkander J, Nixon AB, Daniel LW, O'Flaherty JT. Activation of 85 kDa PLA2 by eicosanoids in human neutrophils and eosinophils Advances in Experimental Medicine and Biology. 416: 327-331. PMID 9131168 DOI: 10.1007/978-1-4899-0179-8_52  0.378
1996 O'Flaherty JT, Kuroki M, Nixon AB, Wijkander J, Yee E, Lee SL, Smitherman PK, Wykle RL, Daniel LW. 5-Oxo-eicosatetraenoate is a broadly active, eosinophil-selective stimulus for human granulocytes. Journal of Immunology (Baltimore, Md. : 1950). 157: 336-42. PMID 8683135  0.353
1996 Nixon AB, Greene DG, Wykle RL. Comparison of acceptor and donor substrats in the CoA-independent transacylase reaction in human neutrophils Biochimica Et Biophysica Acta - Lipids and Lipid Metabolism. 1300: 187-196. PMID 8679683 DOI: 10.1016/0005-2760(96)00011-2  0.401
1996 O'Flaherty JT, Kuroki M, Nixon AB, Wijkander J, Yee E, Lee SL, Smitherman PK, Wykle RL, Daniel LW. 5-Oxo-eicosanoids and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway. The Journal of Biological Chemistry. 271: 17821-8. PMID 8663432 DOI: 10.1074/Jbc.271.30.17821  0.396
1996 Seeds MC, Nixon AB, Wykle RL, Bass DA. Differential activation of human neutrophil cytosolic and secretory phospholipase a2 's during priming by 1,2-DIACYL- And 1O-ALKYL-2-Acylglycerols Journal of Investigative Medicine. 44.  0.338
1995 Huang C, Wykle RL, Daniel LW. Phospholipase D hydrolyzes ether- and ester-linked glycerophospholipids by different pathways in MDCK cells Biochemical and Biophysical Research Communications. 213: 950-957. PMID 7654259 DOI: 10.1006/Bbrc.1995.2221  0.416
1995 Wijkander J, O'Flaherty JT, Nixon AB, Wykle RL. 5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils Journal of Biological Chemistry. 270: 26543-26549. PMID 7592874 DOI: 10.1074/Jbc.270.44.26543  0.461
1994 O'Flaherty JT, Tessner T, Greene D, Redman JR, Wykle RL. Comparison of 1-O-alkyl-, 1-O-alk-1'-enyl-, and 1-O-acyl-2-acetyl-sn-glycero-3-phosphoethanolamines and -3-phosphocholines as agonists of the platelet-activating factor family. Biochimica Et Biophysica Acta. 1210: 209-16. PMID 8280772 DOI: 10.1016/0005-2760(94)90123-6  0.5
1993 Venable ME, Olson SC, Nieto ML, Wykle RL. Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation Journal of Biological Chemistry. 268: 7965-7975. PMID 8463317  0.401
1993 Huang C, Wykle RL, Cabot MC. Comparison of phospholipase D activity in vasopressin- and phorbol ester-stimulated fibroblasts Febs Letters. 319: 141-144. PMID 8454047 DOI: 10.1016/0014-5793(93)80054-X  0.37
1993 Daniel LW, Huang C, Strum JC, Smitherman PK, Greene D, Wykle RL. Phospholipase D hydrolysis of choline phosphoglycerides is selective for the alkyl-linked subclass of Madin-Darby canine kidney cells. The Journal of Biological Chemistry. 268: 21519-26. PMID 8408002  0.309
1993 Strum JC, Nixon AB, Daniel LW, Wykle RL. Evaluation of phospholipase C and D activity in stimulated human neutrophils using a phosphono analog of choline phosphoglyceride Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1169: 25-29. PMID 8334146 DOI: 10.1016/0005-2760(93)90077-M  0.428
1992 Chepenik KP, Wykle RL. Synthesis of platelet activating factor and metabolism of related lipids in embryonic cells Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1126: 192-198. PMID 1627622 DOI: 10.1016/0005-2760(92)90290-C  0.433
1992 Schmitt JD, Nixon AB, Emilsson A, Daniel LW, Wykle RL. A facile synthesis of 1-O-alkyl-2-(R)-hydroxypropane-3-phosphonocholine (lyso-phosphono-platelet activating factor) Chemistry and Physics of Lipids. 62: 263-268. PMID 1468125 DOI: 10.1016/0009-3084(92)90063-U  0.381
1992 Chabot MC, McPhail TLC, Wykle RL, Kennerly DA, McCall CE. Comparison of diglyceride production from choline-containing phosphoglycerides in human neutrophils stimulated with N-formylmethionyl-leucylphenylalanine, ionophore A23187 or phorbol 12-myristate 13-acetate Biochemical Journal. 286: 693-699. PMID 1417727 DOI: 10.1042/Bj2860693  0.398
1991 Nieto ML, Venable ME, Bauldry SA, Greene DG, Kennedy M, Bass DA, Wykle RL. Evidence that hydrolysis of ethanolamine plasmalogens triggers synthesis of platelet-activating factor via a transacylation reaction Journal of Biological Chemistry. 266: 18699-18706. PMID 1917994  0.392
1991 Venable ME, Nieto ML, Schmitt JD, Wykle RL. Conversion of 1-O-[3H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils Journal of Biological Chemistry. 266: 18691-18698. PMID 1917993  0.378
1991 Bauldry HA, Wykle RL, Bass DA. Differential actions of diacyl- and alkylacylglycerols in priming phospholipase A2, 5-lipoxygenase and acetyltransferase activation in human neutrophils Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 1084: 178-184. PMID 1854803 DOI: 10.1016/0005-2760(91)90218-7  0.471
1991 Wykle RL, Strum JC. Lysophospholipase D Methods in Enzymology. 197: 583-590. PMID 1646942 DOI: 10.1016/0076-6879(91)97186-3  0.385
1990 Tessner TG, Greene DG, Wykle RL. Selective deacylation of arachidonate-containing ethanolamine-linked phosphoglycerides in stimulated human neutrophils Journal of Biological Chemistry. 265: 21032-21038. PMID 2250009  0.342
1989 Wykle RL, O'Flaherty JT, Thomas MJ. Platelet-activating factor. Methods in Enzymology. 163: 44-54. PMID 3237085 DOI: 10.1016/0076-6879(88)63006-0  0.373
1989 O'Flaherty JT, Chabot MC, Redman J, Jacobson D, Wykle RL. Receptor-independent metabolism of platelet-activating factor by myelogenous cells. Febs Letters. 250: 341-4. PMID 2546802 DOI: 10.1016/0014-5793(89)80751-3  0.339
1989 Tessner TG, O'Flaherty JT, Wykle RL. Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites Journal of Biological Chemistry. 264: 4794-4799. PMID 2538461  0.425
1989 Agwu DE, McPhail LC, Chabot MC, Daniel LW, Wykle RL, McCall CE. Choline-linked phosphoglycerides. A source of phosphatidic acid and diglycerides in stimulated neutrophils. The Journal of Biological Chemistry. 264: 1405-13. PMID 2492276  0.344
1989 Agwu DE, McPhail LC, Wykle RL, McCall CE. Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by coomassie blue staining and densitometry Biochemical and Biophysical Research Communications. 159: 79-86. PMID 2466463 DOI: 10.1016/0006-291X(89)92407-8  0.445
1988 Banks JB, Wykle RL, O'Flaherty JT, Lumb RH. Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol. Biochimica Et Biophysica Acta. 961: 48-52. PMID 3382692 DOI: 10.1016/0005-2760(88)90129-4  0.421
1988 Bass DA, McPhail LC, Schmitt JD, Morris-Natschke S, McCall CE, Wykle RL. Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C Journal of Biological Chemistry. 263: 19610-19617. PMID 3198643  0.334
1988 Bauldry SA, Wykle RL, Bass DA. Phospholipase A2 activation in human neutrophils. Differential actions of diacylglycerols and alkylacylglycerols in priming cells for stimulation by N-formyl-Met-Leu-Phe Journal of Biological Chemistry. 263: 16787-16795. PMID 2846550  0.306
1988 Surles JR, Marx MH, Piantadosi C, Wykle RL, Schmitt JD. Synthesis and evidence for the stability of a glycerophosphochloridate: rac-1-O-hexadecyl-2-O-(methylcarbamyl)-sn-glycero-3-phosphorochloridocholine The Journal of Organic Chemistry. 53: 899-901. DOI: 10.1021/Jo00239A048  0.355
1987 Wilcox RW, Wykle RL, Schmitt JD, Daniel LW. The degradation of platelet-activating factor and related lipids: Susceptibility to phospholipases C and D Lipids. 22: 800-807. PMID 3444369 DOI: 10.1007/Bf02535534  0.405
1987 Tessner TG, Wykle RL. Stimulated neutrophils produce an ethanolamine plasmalogen analog of platelet-activating factor Journal of Biological Chemistry. 262: 12660-12664. PMID 3114260  0.401
1987 Swendsen CL, Chilton FH, O'Flaherty JT, Suries JR, Piantadosi C, Waite M, Wykle RL. Human neutrophils incorporate arachidonic acid and saturated fatty acids into separate molecular species of phospholipids Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 919: 79-89. PMID 3105590 DOI: 10.1016/0005-2760(87)90220-7  0.342
1987 Chabot MC, Schmitt JD, Bullock BC, Wykle RL. Reacylation of platelet activating factor with eicosapentaenoic acid in fish-oil-enriched monkey neutrophils. Biochimica Et Biophysica Acta. 922: 214-20. PMID 2823907 DOI: 10.1016/0005-2760(87)90157-3  0.411
1987 O'Flaherty JT, Redman JF, Schmitt JD, Ellis JM, Surles JR, Marx MH, Piantadosi C, Wykle RL. 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. Biochemical and Biophysical Research Communications. 147: 18-24. PMID 2820395 DOI: 10.1016/S0006-291X(87)80081-5  0.41
1986 Daniel LW, Waite M, Wykle RL. A novel mechanism of diglyceride formation. 12-O-tetradecanoylphorbol-13-acetate stimulates the cyclic breakdown and resynthesis of phosphatidylcholine Journal of Biological Chemistry. 261: 9128-9132. PMID 3087989  0.312
1986 O'Flaherty JT, Surles JR, Redman J, Jacobson D, Piantadosi C, Wykle RL. Binding and metabolism of platelet-activating factor by human neutrophils Journal of Clinical Investigation. 78: 381-388. PMID 3016027 DOI: 10.1172/Jci112588  0.358
1985 Surles JR, Wykle RL, O'Flaherty JT, Salzer WL, Thomas MJ, Snyder F, Piantadosi C. Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain Journal of Medicinal Chemistry. 28: 73-78. PMID 4038418 DOI: 10.1021/Jm00379A015  0.464
1985 O'Flaherty JT, Schmitt JD, Wykle RL, Redman JF, McCall CE. Diacylglycerols and mezerein activate neutrophils by a phorbol myristate acetate-like mechanism Journal of Cellular Physiology. 125: 192-199. PMID 3932370 DOI: 10.1002/jcp.1041250204  0.332
1985 McCall C, Schmitt J, Cousart S, O'Flaherty J, Bass D, Wykle R. Stimulation of hexose transport by human polymorphonuclear leukocytes: a possible role for protein kinase C. Biochemical and Biophysical Research Communications. 126: 450-6. PMID 3155945 DOI: 10.1016/0006-291X(85)90626-6  0.409
1985 O'Flaherty JT, Schmitt JD, Wykle RL. Interactions of arachidonate metabolism and protein kinase C in mediating neutrophil function Biochemical and Biophysical Research Communications. 127: 916-923. PMID 2985065 DOI: 10.1016/S0006-291X(85)80031-0  0.407
1985 Wyrick SD, McClanahan JS, Wykle RL, O'Flaherty JT. Tritiated hexadecyl platelet activating factor (PAF) Journal of Labelled Compounds and Radiopharmaceuticals. 22: 1169-1174. DOI: 10.1002/Jlcr.2580221110  0.383
1984 McNamara MJC, Schmitt JD, Wykle RL, Daniel LW. 1-O-hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells Biochemical and Biophysical Research Communications. 122: 824-830. PMID 6590040 DOI: 10.1016/S0006-291X(84)80108-4  0.376
1984 Mueller HW, O'Flaherty JT, Wykle RL. The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils Journal of Biological Chemistry. 259: 14554-14559. PMID 6501307  0.412
1984 Chilton FH, Ellis JM, Olson SC, Wykle RL. 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes. The Journal of Biological Chemistry. 259: 12014-9. PMID 6434535  0.374
1984 O'Flaherty JT, Schmitt JD, McCall CE, Wykle RL. Diacylglycerols enhance human neutrophil degranulation responses: Relevancy to a multiple mediator hypothesis of cell function Biochemical and Biophysical Research Communications. 123: 64-70. PMID 6433920 DOI: 10.1016/0006-291X(84)90380-2  0.473
1984 Mueller HW, O'Flaherty JT, Greene DG, Samuel MP, Wykle RL. 1-O-Alkyl-linked glycerophospholipids of human neutrophils: Distribution of arachidonate and other acyl residues in the ether-linked and diacyl species Journal of Lipid Research. 25: 383-388. PMID 6427378  0.351
1983 Chilton FH, O'Flaherty JT, Ellis JM, Swendsen CL, Wykle RL. Metabolic fate of platelet-activating factor in neutrophils. The Journal of Biological Chemistry. 258: 6357-61. PMID 6853486  0.349
1983 O'Flaherty JT, Salzer WL, Cousart S, McCall CE, Piantadosi C, Surles JR, Hammett MJ, Wykle RL. Platelet-activating factor and analogues: comparative studies with human neutrophils and rabbit platelets. Research Communications in Chemical Pathology and Pharmacology. 39: 291-309. PMID 6844746  0.325
1983 Mueller HW, Purdon AD, Smith JB, Wykle RL. 1-O-alkyl-linked phosphoglycerides of human platelets: Distribution of arachidonate and other acyl residues in the ether-linked and diacyl species Lipids. 18: 814-819. PMID 6419001 DOI: 10.1007/Bf02534641  0.443
1983 Swendsen CL, Ellis JM, Chilton FH, O'Flaherty JT, Wykle RL. 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine: a novel source of arachidonic acid in neutrophils stimulated by the calcium ionophore A23187. Biochemical and Biophysical Research Communications. 113: 72-9. PMID 6407484 DOI: 10.1016/0006-291X(83)90433-3  0.48
1983 O'Flaherty JT, Thomas MJ, Hammett MJ, Carroll C, McCall CE, Wykle RL. 5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor Biochemical and Biophysical Research Communications. 111: 1-7. PMID 6403011 DOI: 10.1016/S0006-291X(83)80108-9  0.362
1983 Walsh CE, Dechatelet LR, Chilton FH, Wykle RL, Waite M. Mechanism of arachidonic acid release in human polymorphonuclear leukocytes. Biochimica Et Biophysica Acta. 750: 32-40. PMID 6402027 DOI: 10.1016/0005-2760(83)90201-1  0.379
1983 O'Flaherty JT, Wykle RL. Biology and biochemistry of platelet-activating factor Clinical Reviews in Allergy. 1: 353-367. PMID 6370406 DOI: 10.1007/Bf02991226  0.374
1982 Mueller HW, O'Flaherty JT, Wykle RL. Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids Lipids. 17: 72-77. PMID 7087685 DOI: 10.1007/Bf02535178  0.447
1982 Wykle RL, Surles JR, Piantadosi C, Salzer WL, O'Flaherty JT. Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine). Activity of analogs lacking oxygen at the 2-position Febs Letters. 141: 29-32. PMID 7084476 DOI: 10.1016/0014-5793(82)80008-2  0.441
1982 Chilton FH, O'Flaherty JT, Walsh CE, Thomas MJ, Wykle RL, DeChatelet LR, Waite BM. Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. The Journal of Biological Chemistry. 257: 5402-7. PMID 6802816  0.303
1981 O'Flaherty JT, Miller CH, Lewis JC, Wykle RL, Bass DA, McCall CE, Waite M, DeChatelet LR. Neutrophil responses to platelet-activating factor Inflammation. 5: 193-201. PMID 7298160 DOI: 10.1007/Bf00914443  0.482
1981 Wykle RL, Miller CH, Lewis JC, Schmitt JD, Smith JA, Surles JR, Piantadosi C, O'Flaherty JT. Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils Biochemical and Biophysical Research Communications. 100: 1651-1658. PMID 7295320 DOI: 10.1016/0006-291X(81)90708-7  0.415
1981 O'flaherty JT, Lees CJ, Miller CH, McCall CE, Lewis JC, Love SH, Wykle RL. Selective desensitization of neutrophils: Further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues Journal of Immunology. 127: 731-737. PMID 7252157  0.371
1981 O'Flaherty JT, Wykle RL, Miller CH, Lewis JC, Waite M, Bass DA, McCall CE, DeChatelet LR. 1-O-Alkyl-sn-glyceryl-3-phosphorylcholines. A novel class of neutrophil stimulants American Journal of Pathology. 103: 70-78. PMID 7223864  0.379
1981 O'Flaherty JT, Hammett MJ, Shewmake TB, Wykle RL, Love SH, McCall CE, Thomas MJ. Evidence for 5,12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation Biochemical and Biophysical Research Communications. 103: 552-558. PMID 6277309 DOI: 10.1016/0006-291X(81)90487-3  0.346
1981 O'Flaherty JT, Wykle RL, Lees CJ, Shewmake T, McCall CE, Thomas MJ. Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents American Journal of Pathology. 105: 264-269. PMID 6274199  0.344
1981 O'Flaherty JT, Wykle RL, McCall CE, Shewmake TB, Lees CJ, Thomas M. Desensitization of the human neutrophil degranulation response: Studies with 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid Biochemical and Biophysical Research Communications. 101: 1290-1296. PMID 6272779 DOI: 10.1016/0006-291X(81)91587-4  0.342
1979 Wykle RL. Biosynthesis of plasmalogens by the microsomal fraction of fischer R-3259 sarcoma. Influence of specific 2-acyl chains on the desaturation of 1-alkyl-2-acyl-sn-glycero- 3-phosphoethanolamine Biochemistry. 18: 3512-3517. PMID 476064 DOI: 10.1021/Bi00583A012  0.314
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