Peter Wipf - Publications

University of Pittsburgh, Pittsburgh, PA, United States 
Chemical Biology

399 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.


Year Citation  Score
2021 Rand D, Ravid O, Atrakchi D, Israelov H, Bresler Y, Shemesh C, Omesi L, Liraz-Zaltsman S, Gosselet F, Maskrey TS, Beeri MS, Wipf P, Cooper I. Endothelial Iron Homeostasis Regulates Blood-Brain Barrier Integrity via the HIF2α-Ve-Cadherin Pathway. Pharmaceutics. 13. PMID 33670876 DOI: 10.3390/pharmaceutics13030311  0.56
2021 Tasker NR, Wipf P. Biosynthesis, total synthesis, and biological profiles of Ergot alkaloids. The Alkaloids. Chemistry and Biology. 85: 1-112. PMID 33663751 DOI: 10.1016/bs.alkal.2020.08.001  0.6
2021 Lu P, Yamaguchi Y, Fulton WB, Wang S, Zhou Q, Jia H, Kovler ML, Salazar AG, Sampah M, Prindle T, Wipf P, Sodhi CP, Hackam DJ. Maternal aryl hydrocarbon receptor activation protects newborns against necrotizing enterocolitis. Nature Communications. 12: 1042. PMID 33589625 DOI: 10.1038/s41467-021-21356-4  0.56
2021 Marinos L, Kouvaros S, Bizup B, Hambach B, Wipf P, Tzounopoulos T. Transient Delivery of a KCNQ2/3-Specific Channel Activator 1 Week After Noise Trauma Mitigates Noise-Induced Tinnitus. Journal of the Association For Research in Otolaryngology : Jaro. PMID 33575914 DOI: 10.1007/s10162-021-00786-3  0.44
2020 Lv S, Song Q, Chen G, Cheng E, Chen W, Cole R, Wu Z, Pascal LE, Wang K, Wipf P, Nelson JB, Wei Q, Huang W, Wang Z. Regulation and targeting of androgen receptor nuclear localization in castration-resistant prostate cancer. The Journal of Clinical Investigation. PMID 33332287 DOI: 10.1172/JCI141335  0.64
2020 Mlakar L, Lane J, Takihara T, Lim C, Sprachman MM, Lloyd KR, Wipf P, Feghali-Bostwick C. Oxetanyl Sulfoxide MMS-350 Ameliorates Pulmonary Fibrosis , , and . Acs Medicinal Chemistry Letters. 11: 2312-2317. PMID 33214846 DOI: 10.1021/acsmedchemlett.0c00433  0.88
2020 Sodhi CP, Wipf P, Yamaguchi Y, Fulton WB, Kovler M, Niño DF, Zhou Q, Banfield E, Werts AD, Ladd MR, Buck RH, Goehring KC, Prindle T, Wang S, Jia H, et al. Insights image for "The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling." Pediatric Research. PMID 32998155 DOI: 10.1038/s41390-020-01184-w  0.56
2020 Glänzel NM, Grings M, da Rosa-Junior NT, de Carvalho LMC, Mohsen AW, Wipf P, Wajner M, Vockley J, Leipnitz G. The mitochondrial-targeted reactive species scavenger JP4-039 prevents sulfite-induced alterations in antioxidant defenses, energy transfer and cell death signaling in striatum of rats. Journal of Inherited Metabolic Disease. PMID 32882059 DOI: 10.1002/jimd.12310  0.6
2020 Terrab L, Rosenker CJ, Johnstone L, Ngo LK, Zhang L, Ware NF, Miller B, Topacio AZ, Sannino S, Brodsky JL, Wipf P. Synthesis and Selective Functionalization of Thiadiazine 1,1-Dioxides with Efficacy in a Model of Huntington's Disease. Acs Medicinal Chemistry Letters. 11: 984-990. PMID 32435415 DOI: 10.1021/acsmedchemlett.0c00018  0.52
2020 Sodhi CP, Wipf P, Yamaguchi Y, Fulton WB, Kovler M, Niño DF, Zhou Q, Banfield E, Werts AD, Ladd MR, Buck RH, Goehring KC, Prindle T, Wang S, Jia H, et al. The human milk oligosaccharides 2'-fucosyllactose and 6'-sialyllactose protect against the development of necrotizing enterocolitis by inhibiting toll-like receptor 4 signaling. Pediatric Research. PMID 32221473 DOI: 10.1038/s41390-020-0852-3  0.56
2020 Thermozier S, Hou W, Zhang X, Shields D, Fisher R, Bayir H, Kagan V, Yu J, Liu B, Bahar I, Epperly MW, Wipf P, Wang H, Huq MS, Greenberger JS. Anti-Ferroptosis Drug Enhances Total-Body Irradiation Mitigation by Drugs that Block Apoptosis and Necroptosis. Radiation Research. PMID 32134361 DOI: 10.1667/RR15486.1  0.64
2020 Zhang X, Fisher R, Hou W, Shields D, Epperly MW, Wang H, Wei L, Leibowitz BJ, Yu J, Alexander LM, VAN Pijkeren JP, Watkins S, Wipf P, Greenberger JS. Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation. In Vivo (Athens, Greece). 34: 39-50. PMID 31882461 DOI: 10.21873/invivo.11743  0.64
2020 Epperly MW, Fisher R, Zhang X, Hou W, Shields D, Wipf P, Wang H, Thermozier S, Greenberger JS. Fanconi Anemia Mouse Genotype-specific Mitigation of Total Body Irradiation by GS-Nitroxide JP4-039. In Vivo (Athens, Greece). 34: 33-38. PMID 31882460 DOI: 10.21873/invivo.11742  0.64
2019 Wu Z, Wang K, Yang Z, Pascal LE, Nelson JB, Takubo K, Wipf P, Wang Z. A novel androgen receptor antagonist JJ-450 inhibits enzalutamide-resistant mutant AR nuclear import and function. The Prostate. PMID 31868960 DOI: 10.1002/pros.23945  0.64
2019 Tai S, Maskrey TS, Nyalapatla PR, Wipf P. Co(II)-salen catalyzed stereoselective cyclopropanation of fluorinated styrenes. Chirality. PMID 31680333 DOI: 10.1002/chir.23144  0.56
2019 Quinn TJ, Ding X, Li X, Wilson GD, Buelow K, Sivananthan A, Thermozier S, Henderson A, Epperly MW, Franicola D, Wipf P, Greenberger JS, Stevens CW, Kabolizadeh P. Amelioration of Mucositis in Proton Therapy of Fanconi Anemia Fanca Mice by JP4-039. In Vivo (Athens, Greece). 33: 1757-1766. PMID 31662500 DOI: 10.21873/invivo.11666  0.64
2019 Lazo JS, Blanco IK, Tasker NR, Rastelli EJ, Burnett JC, Garrott SR, Hart DJ, McCloud RL, Hsu KL, Wipf P, Sharlow ER. Next-Generation Cell-active Inhibitors of the Undrugged Oncogenic PTP4A3 Phosphatase. The Journal of Pharmacology and Experimental Therapeutics. PMID 31601683 DOI: 10.1124/jpet.119.262188  0.6
2019 Sen M, Kindsfather A, Danilova L, Zhang F, Colombo R, LaPorte MG, Kurland BF, Huryn DM, Wipf P, Herman JG. PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies. Epigenetics. PMID 31595832 DOI: 10.1080/15592294.2019.1676597  0.52
2019 Yang Z, Wang D, Johnson JK, Pascal LE, Takubo K, Avula R, Chakka AB, Zhou J, Chen W, Zhong M, Song Q, Ding H, Wu Z, Chandran UR, Maskrey TS, ... ... Wipf P, et al. A novel small molecule targets androgen receptor and its splice variants in castration-resistant prostate cancer. Molecular Cancer Therapeutics. PMID 31554654 DOI: 10.1158/1535-7163.MCT-19-0489  0.64
2019 Huryn DM, Kornfilt DJP, Wipf P. p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections. Journal of Medicinal Chemistry. PMID 31550150 DOI: 10.1021/acs.jmedchem.9b01318  0.32
2019 Grings M, Seminotti B, Karunanidhi A, Ghaloul-Gonzalez L, Mohsen AW, Wipf P, Palmfeldt J, Vockley J, Leipnitz G. ETHE1 and MOCS1 deficiencies: Disruption of mitochondrial bioenergetics, dynamics, redox homeostasis and endoplasmic reticulum-mitochondria crosstalk in patient fibroblasts. Scientific Reports. 9: 12651. PMID 31477743 DOI: 10.1038/s41598-019-49014-2  0.6
2019 Peyser BD, Hermone A, Salamoun JM, Burnett JC, Hollingshead MG, McGrath CF, Gussio R, Wipf P. Specific RITA modification produces hyperselective cytotoxicity while maintaining in vivo antitumor efficacy. Molecular Cancer Therapeutics. PMID 31341033 DOI: 10.1158/1535-7163.MCT-19-0185  0.44
2019 Tasker NR, Rastelli EJ, Burnett JC, Sharlow ER, Lazo JS, Wipf P. Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 31307888 DOI: 10.1016/j.bmcl.2019.06.048  0.6
2019 Liu R, Tzounopoulos T, Wipf P. Synthesis and Optimization of K7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity. Acs Medicinal Chemistry Letters. 10: 929-935. PMID 31223450 DOI: 10.1021/acsmedchemlett.9b00097  0.44
2019 Epperly MW, Fisher R, Rigatti L, Watkins S, Zhang X, Hou W, Shields D, Franicola D, Bayir H, Wang H, Thermozier S, Henderson A, Donnelly C, Wipf P, Greenberger JS. Amelioration of Amyotrophic Lateral Sclerosis in SOD1 Mice by M Microglia from Transplanted Marrow. In Vivo (Athens, Greece). 33: 675-688. PMID 31028184 DOI: 10.21873/invivo.11526  0.64
2019 Cao L, Wang C, Wipf P. Grob-Type Fragmentation Releases Paracyclophane Ring Strain in a Late-Stage Precursor of Haouamine A. Organic Letters. PMID 30779589 DOI: 10.1021/acs.orglett.9b00424  1
2019 Tasker NR, Rastelli EJ, Blanco IK, Burnett JC, Sharlow ER, Lazo JS, Wipf P. In-flow photooxygenation of aminothienopyridinones generates iminopyridinedione PTP4A3 phosphatase inhibitors. Organic & Biomolecular Chemistry. PMID 30746541 DOI: 10.1039/c9ob00025a  0.6
2018 Chiang AN, Liang M, Dominguez-Meijide A, Masaracchia C, Goeckeler-Fried JL, Mazzone CS, Newhouse DW, Kendsersky NM, Yates ME, Manos-Turvey A, Needham PG, Outeiro TF, Wipf P, Brodsky JL. Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding. Bioorganic & Medicinal Chemistry. PMID 30528127 DOI: 10.1016/j.bmc.2018.11.011  0.48
2018 Sivananthan A, Shields D, Fisher R, Hou W, Zhang X, Franicola D, Epperly MW, Wipf P, Greenberger JS. Continuous One Year Oral Administration of the Radiation Mitigator, MMS350, after Total-Body Irradiation, Restores Bone Marrow Stromal Cell Proliferative Capacity and Reduces Senescence in Fanconi Anemia (Fanca) Mice. Radiation Research. PMID 30499383 DOI: 10.1667/RR15199.1  0.64
2018 Skiba MA, Bivins MM, Schultz JR, Bernard SM, Fiers WD, Dan Q, Kulkarni S, Wipf P, Gerwick WH, Sherman DH, Aldrich CC, Smith JL. Structural Basis of Polyketide Synthase O-Methylation. Acs Chemical Biology. PMID 30489068 DOI: 10.1021/acschembio.8b00687  0.32
2018 Seminotti B, Leipnitz G, Karunanidhi A, Kochersperger C, Roginskaya VY, Basu S, Wang Y, Wipf P, Van Houten B, Mohsen AW, Vockley J. Mitochondrial energetics is impaired in very long-chain acyl-CoA dehydrogenase deficiency and can be rescued by treatment with mitochondria-targeted electron scavengers. Human Molecular Genetics. PMID 30445591 DOI: 10.1093/hmg/ddy403  0.6
2018 LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. Acs Medicinal Chemistry Letters. 9: 1075-1081. PMID 30429948 DOI: 10.1021/acsmedchemlett.8b00372  0.88
2018 Dong J, Wu Z, Wang D, Pascal LE, Nelson JB, Wipf P, Wang Z. Hsp70 binds to the androgen receptor N-terminal domain and modulates the receptor function in prostate cancer cells. Molecular Cancer Therapeutics. PMID 30297360 DOI: 10.1158/1535-7163.MCT-18-0432  0.64
2018 Maskrey TS, Frischling MC, Rice ML, Wipf P. A Five-Component Biginelli-Diels-Alder Cascade Reaction. Frontiers in Chemistry. 6: 376. PMID 30211156 DOI: 10.3389/fchem.2018.00376  0.56
2018 Krainz T, Lamade A, Du L, Maskrey T, Calderon M, Watkins S, Epperly M, Greenberger JS, Bayir H, Wipf P, Clark R. Synthesis and Evaluation of a Mitochondria-Targeting Poly(ADP-ribose) Polymerase-1 Inhibitor. Acs Chemical Biology. PMID 30184433 DOI: 10.1021/acschembio.8b00423  0.56
2018 Brand RM, Wipf P, Durham A, Epperly MW, Greenberger JS, Falo LD. Targeting Mitochondrial Oxidative Stress to Mitigate UV-Induced Skin Damage. Frontiers in Pharmacology. 9: 920. PMID 30177881 DOI: 10.3389/fphar.2018.00920  0.64
2018 Epperly MW, Wipf P, Fisher R, Franicola D, Beumer J, Li S, Brand RM, Falo LD, Erdos G, Greenberger JS. Evaluation of Different Formulations and Routes for the Delivery of the Ionizing Radiation Mitigator GS-Nitroxide (JP4-039). In Vivo (Athens, Greece). 32: 1009-1023. PMID 30150422 DOI: 10.21873/invivo.11341  0.88
2018 Saydmohammed M, Vollmer LL, Onuoha EO, Maskrey TS, Gibson G, Watkins SC, Wipf P, Vogt A, Tsang M. A High-Content Screen Reveals New Small-Molecule Enhancers of Ras/Mapk Signaling as Probes for Zebrafish Heart Development. Molecules (Basel, Switzerland). 23. PMID 29997348 DOI: 10.3390/molecules23071691  0.56
2018 Lou W, Ting HC, Reynolds CJ, Tyurina YY, Tyurin VA, Li Y, Ji J, Yu W, Liang Z, Stoyanovsky DA, Anthonymuthu TS, Frasso MA, Wipf P, Greenberger JS, Bayir H, et al. Genetic re-engineering of polyunsaturated phospholipid profile of Saccharomyces cerevisiae identifies a novel role for Cld1 in mitigating the effects of cardiolipin peroxidation. Biochimica Et Biophysica Acta. PMID 29935382 DOI: 10.1016/j.bbalip.2018.06.016  0.56
2018 Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, ... ... Wipf P, et al. Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging. Redox Biology. 17: 259-273. PMID 29747066 DOI: 10.1016/j.redox.2018.04.007  0.4
2018 McQueeney KE, Salamoun JM, Ahn JG, Pekic P, Blanco IK, Struckman HL, Sharlow ER, Wipf P, Lazo JS. A chemical genetics approach identifies PTP4A3 as a regulator of colon cancer cell adhesion. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701446R. PMID 29746167 DOI: 10.1096/fj.201701446R  0.56
2018 Yang X, Xia R, Yue C, Zhai W, Du W, Yang Q, Cao H, Chen X, Obando D, Zhu Y, Chen X, Chen JJ, Piganelli J, Wipf P, Jiang Y, et al. ATF4 Regulates CD4 T Cell Immune Responses through Metabolic Reprogramming. Cell Reports. 23: 1754-1766. PMID 29742431 DOI: 10.1016/j.celrep.2018.04.032  0.72
2018 Willis J, Epperly MW, Fisher R, Zhang X, Shields D, Hou W, Wang H, Li S, Wipf P, Parmar K, Guinan E, Steinman J, Greenberger JS. Amelioration of Head and Neck Radiation-Induced Mucositis and Distant Marrow Suppression in Fancaand FancgMice by Intraoral Administration of GS-Nitroxide (JP4-039). Radiation Research. PMID 29584588 DOI: 10.1667/RR14878.1  0.88
2018 McQueeney KE, Salamoun JM, Burnett JC, Barabutis N, Pekic P, Lewandowski SL, Llaneza DC, Cornelison R, Bai Y, Zhang ZY, Catravas JD, Landen CN, Wipf P, Lazo JS, Sharlow ER. Targeting ovarian cancer and endothelium with an allosteric PTP4A3 phosphatase inhibitor. Oncotarget. 9: 8223-8240. PMID 29492190 DOI: 10.18632/oncotarget.23787  0.56
2018 Ma J, Salamoun J, Wipf P, Edwards R, Van Houten B, Qian W. Combination of a thioxodihydroquinazolinone with cisplatin eliminates ovarian cancer stem cell-like cells (CSC-LCs) and shows preclinical potential. Oncotarget. 9: 6042-6054. PMID 29464053 DOI: 10.18632/oncotarget.23679  0.6
2018 Wei L, Leibowitz BJ, Epperly M, Bi C, Li A, Steinman J, Wipf P, Li S, Zhang L, Greenberger J, Yu J. The GS-nitroxide JP4-039 improves intestinal barrier and stem cell recovery in irradiated mice. Scientific Reports. 8: 2072. PMID 29391546 DOI: 10.1038/s41598-018-20370-9  0.88
2018 Leipnitz G, Mohsen AW, Karunanidhi A, Seminotti B, Roginskaya VY, Markantone DM, Grings M, Mihalik SJ, Wipf P, Van Houten B, Vockley J. Evaluation of mitochondrial bioenergetics, dynamics, endoplasmic reticulum-mitochondria crosstalk, and reactive oxygen species in fibroblasts from patients with complex I deficiency. Scientific Reports. 8: 1165. PMID 29348607 DOI: 10.1038/s41598-018-19543-3  0.6
2017 Wu M, White HV, Boehm B, Meriney CJ, Kerrigan K, Frasso M, Liang M, Gotway EM, Wilcox M, Johnson JW, Wipf P, Meriney SD. New Cav2 calcium channel gating modifiers with agonist activity and therapeutic potential to treat neuromuscular disease. Neuropharmacology. PMID 29246857 DOI: 10.1016/j.neuropharm.2017.12.022  0.48
2017 Christner S, Guo J, Parise RA, Ringeval M, Hoye AT, Wipf P, Epperly MW, Greenberger JS, Beumer JH, Eiseman JL. Liquid chromatography-tandem mass spectrometric assay for the quantitation of the novel radiation protective agent and radiation mitigator JP4-039 in murine plasma. Journal of Pharmaceutical and Biomedical Analysis. 150: 169-175. PMID 29245086 DOI: 10.1016/j.jpba.2017.12.023  0.92
2017 Steinman J, Epperly M, Hou W, Willis J, Wang H, Fisher R, Liu B, Bahar I, McCaw T, Kagan V, Bayir H, Yu J, Wipf P, Li S, Huq MS, et al. Improved Total-Body Irradiation Survival by Delivery of Two Radiation Mitigators that Target Distinct Cell Death Pathways. Radiation Research. PMID 29140165 DOI: 10.1667/RR14787.1  0.88
2017 Meriney SD, Tarr TB, Ojala KS, Wu M, Li Y, Lacomis D, Garcia-Ocaña A, Liang M, Valdomir G, Wipf P. Lambert-Eaton myasthenic syndrome: mouse passive-transfer model illuminates disease pathology and facilitates testing therapeutic leads. Annals of the New York Academy of Sciences. PMID 29125190 DOI: 10.1111/nyas.13512  0.48
2017 Masoodi KZ, Eisermann K, Yang Z, Dar JA, Pascal LE, Nguyen M, O'Malley K, Parrinello E, Feturi FG, Kenefake AN, Nelson JB, Johnston PA, Wipf P, Wang Z. Inhibition of Androgen Receptor Function and Level in Castration-Resistant Prostate Cancer Cells by 2-[(isoxazol-4-ylmethyl)thio]-1-(4-phenylpiperazin-1-yl)ethanone. Endocrinology. 158: 3152-3161. PMID 28977599 DOI: 10.1210/en.2017-00408  0.64
2017 Lazo JS, McQueeney KE, Burnett JC, Wipf P, Sharlow ER. Small molecule targeting of PTPs in cancer. The International Journal of Biochemistry & Cell Biology. PMID 28943273 DOI: 10.1016/j.biocel.2017.09.011  0.56
2017 Xu J, Wipf P. Indole synthesis by palladium-catalyzed tandem allylic isomerization - furan Diels-Alder reaction. Organic & Biomolecular Chemistry. PMID 28813061 DOI: 10.1039/c7ob01654a  0.56
2017 Sen M, Johnston PA, Pollock NI, DeGrave K, Joyce SC, Freilino ML, Hua Y, Camarco DP, Close DA, Huryn DM, Wipf P, Grandis JR. Mechanism of action of selective inhibitors of IL-6 induced STAT3 pathway in head and neck cancer cell lines. Journal of Chemical Biology. 10: 129-141. PMID 28684999 DOI: 10.1007/s12154-017-0169-9  0.52
2017 Masoodi KZ, Xu Y, Dar JA, Eisermann K, Pascal LE, Parrinello E, Ai J, Johnston PA, Nelson JB, Wipf P, Wang Z. Inhibition of Androgen Receptor Nuclear Localization and Castration Resistant Prostate Tumor Growth by Pyrroloimidazole-Based Small Molecules. Molecular Cancer Therapeutics. PMID 28655783 DOI: 10.1158/1535-7163.MCT-17-0176  0.64
2017 Epperly MW, Rhieu BH, Franicola D, Dixon T, Cao S, Zhang X, Shields D, Wang H, Wipf P, Greenberger JS. Induction of TGF-β by Irradiation or Chemotherapy in Fanconi Anemia (FA) Mouse Bone Marrow Is Modulated by Small Molecule Radiation Mitigators JP4-039 and MMS350. In Vivo (Athens, Greece). 31: 159-168. PMID 28358695 DOI: 10.21873/invivo.11040  0.64
2017 Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P. A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site. Organic & Biomolecular Chemistry. PMID 28352916 DOI: 10.1039/c7ob00526a  0.6
2017 Epperly MW, Sacher JR, Krainz T, Zhang X, Wipf P, Liang M, Fisher R, Li S, Wang H, Greenberger JS. Effectiveness of Analogs of the GS-Nitroxide, JP4-039, as Total Body Irradiation Mitigators. In Vivo (Athens, Greece). 31: 39-43. PMID 28064218 DOI: 10.21873/invivo.11022  0.88
2016 Tyurina YY, Lou W, Qu F, Tyurin VA, Mohammadyani D, Liu J, Hüttemann M, Frasso MA, Wipf P, Bayir H, Greenberg ML, Kagan VE. Lipidomics Characterization of Biosynthetic and Remodeling Pathways of Cardiolipins in Genetically and Nutritionally Manipulated Yeast Cells. Acs Chemical Biology. PMID 27982579 DOI: 10.1021/acschembio.6b00995  0.44
2016 Brand RM, Epperly MW, Stottlemyer JM, Skoda EM, Gao X, Li S, Huq S, Wipf P, Kagan VE, Greenberger JS, Falo LD. A Topical Mitochondria-Targeted Redox Cycling Nitroxide Mitigates Oxidative Stress Induced Skin Damage. The Journal of Investigative Dermatology. PMID 27794421 DOI: 10.1016/j.jid.2016.09.033  0.88
2016 Krainz T, Gaschler MM, Lim C, Sacher JR, Stockwell BR, Wipf P. A Mitochondrial-Targeted Nitroxide Is a Potent Inhibitor of Ferroptosis. Acs Central Science. 2: 653-659. PMID 27725964 DOI: 10.1021/acscentsci.6b00199  0.6
2016 Epperly M, Rigatti L, Li S, Wipf P, Greenberger JS. Small Molecule GS-Nitroxide Radiation Mitigator JP4-039/F14 Is Safe and Effective in Pregnant E13.5 Mice. International Journal of Radiation Oncology, Biology, Physics. 96: E568. PMID 27675038 DOI: 10.1016/j.ijrobp.2016.06.2050  0.88
2016 Epperly M, Krainz T, Zhang X, Li S, Wipf P, Greenberger JS. Novel Small Molecule Mitochondrial Targeted Nitroxides Mitigate Total Body Irradiation. International Journal of Radiation Oncology, Biology, Physics. 96: E567. PMID 27675036 DOI: 10.1016/j.ijrobp.2016.06.2048  0.88
2016 Manos-Turvey A, Al-Ashtal HA, Needham PG, Hartline CB, Prichard MN, Wipf P, Brodsky JL. Dihydropyrimidinones and -thiones with improved activity against human polyomavirus family members. Bioorganic & Medicinal Chemistry Letters. PMID 27624078 DOI: 10.1016/j.bmcl.2016.08.080  0.4
2016 Johnson JK, Skoda EM, Zhou J, Parrinello E, Wang D, O'Malley K, Eyer BR, Kazancioglu M, Eisermann K, Johnston PA, Nelson JB, Wang Z, Wipf P. Small Molecule Antagonists of the Nuclear Androgen Receptor for the Treatment of Castration-Resistant Prostate Cancer. Acs Medicinal Chemistry Letters. 7: 785-90. PMID 27563404 DOI: 10.1021/acsmedchemlett.6b00186  1
2016 Milligan JA, Busacca CA, Senanayake CH, Wipf P. Hydrophosphination of Bicyclo[1.1.0]butane-1-carbonitriles. Organic Letters. PMID 27518583 DOI: 10.1021/acs.orglett.6b02051  0.48
2016 Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27450084 DOI: 10.1073/pnas.1603883113  0.36
2016 Colombo R, Wang Z, Han J, Balachandran R, Daghestani HN, Camarco DP, Vogt A, Day BW, Mendel D, Wipf P. Total Synthesis and Biological Evaluation of Tubulysin Analogs. The Journal of Organic Chemistry. PMID 27447195 DOI: 10.1021/acs.joc.6b01314  0.88
2016 LaPorte MG, Wang Z, Colombo R, Garzan A, Peshkov VA, Liang M, Johnston PA, Schurdak ME, Sen M, Camarco DP, Hua Y, Pollock NI, Lazo JS, Grandis JR, Wipf P, et al. Optimization of pyrazole-containing 1,2,4-triazolo-[3,4-b]thiadiazines, a new class of STAT3 pathway inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 27381083 DOI: 10.1016/j.bmcl.2016.06.017  0.4
2016 Salamoun JM, McQueeney KE, Patil K, Geib SJ, Sharlow ER, Lazo JS, Wipf P. Photooxygenation of an amino-thienopyridone yields a more potent PTP4A3 inhibitor. Organic & Biomolecular Chemistry. PMID 27291491 DOI: 10.1039/c6ob00946h  0.56
2016 Johnston PA, Nguyen MM, Dar JA, Ai J, Wang Y, Masoodi KZ, Shun T, Shinde S, Camarco DP, Hua Y, Huryn DM, Wilson GM, Lazo JS, Nelson JB, Wipf P, et al. Development and Implementation of a High-Throughput High-Content Screening Assay to Identify Inhibitors of Androgen Receptor Nuclear Localization in Castration-Resistant Prostate Cancer Cells. Assay and Drug Development Technologies. 14: 226-39. PMID 27187604 DOI: 10.1089/adt.2016.716  0.4
2016 Kumar M, Reed N, Liu R, Aizenman E, Wipf P, Tzounopoulos T. Synthesis and Evaluation of Potent KCNQ2/3-specific Channel Activators. Molecular Pharmacology. PMID 27005699 DOI: 10.1124/mol.115.103200  0.44
2016 Milligan JA, Wipf P. Click chemistry: Straining to react. Nature Chemistry. 8: 296-7. PMID 27001724 DOI: 10.1038/nchem.2485  1
2016 Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, ... ... Wipf P, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. Acs Medicinal Chemistry Letters. 7: 182-7. PMID 26985295 DOI: 10.1021/acsmedchemlett.5b00396  0.52
2016 Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science (New York, N.Y.). PMID 26822609 DOI: 10.1126/science.aad7974  0.4
2016 Shinde A, Berhane H, Rhieu BH, Kalash R, Xu K, Goff J, Epperly MW, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Parmar K, Guinan E, et al. Intraoral Mitochondrial-Targeted GS-Nitroxide, JP4-039, Radioprotects Normal Tissue in Tumor-Bearing Radiosensitive Fancd2(-/-) (C57BL/6) Mice. Radiation Research. PMID 26789701 DOI: 10.1667/RR14035.1  0.4
2016 Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, ... ... Wipf P, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Acs Medicinal Chemistry Letters. 7: 182-187. DOI: 10.1021/acsmedchemlett.5b00396  1
2016 Manos-Turvey A, Brodsky JL, Wipf P. The effect of structure and mechanism of the Hsp70 chaperone on the ability to identify chemical modulators and therapeutics Topics in Medicinal Chemistry. 19: 81-129. DOI: 10.1007/7355_2015_90  1
2015 Greenberger J, Kagan V, Bayir H, Wipf P, Epperly M. Antioxidant Approaches to Management of Ionizing Irradiation Injury. Antioxidants (Basel, Switzerland). 4: 82-101. PMID 26785339 DOI: 10.3390/antiox4010082  0.52
2015 Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. Acs Medicinal Chemistry Letters. 6: 1225-30. PMID 26713109 DOI: 10.1021/acsmedchemlett.5b00364  0.6
2015 Wilson BA, Alam MS, Guszczynski T, Jakob M, Shenoy SR, Mitchell CA, Goncharova EI, Evans JR, Wipf P, Liu G, Ashwell JD, O'Keefe BR. Discovery and Characterization of a Biologically Active Non-ATP-Competitive p38 MAP Kinase Inhibitor. Journal of Biomolecular Screening. PMID 26538432 DOI: 10.1177/1087057115615518  0.4
2015 Wu S, Guo Z, Hopkins CD, Wei N, Chu E, Wipf P, Schmitz JC. Bis-cyclopropane analog of disorazole C1 is a microtubule-destabilizing agent active in ABCB1-overexpressing human colon cancer cells. Oncotarget. PMID 26506423 DOI: 10.18632/oncotarget.5885  0.4
2015 Javadov S, Jang S, Rodriguez-Reyes N, Rodriguez-Zayas AE, Soto Hernandez J, Krainz T, Wipf P, Frontera W. Mitochondria-targeted antioxidant preserves contractile properties and mitochondrial function of skeletal muscle in aged rats. Oncotarget. PMID 26415224 DOI: 10.18632/oncotarget.5783  0.4
2015 Johnston PA, Sen M, Hua Y, Camarco DP, Shun TY, Lazo JS, Wilson GM, Resnick LO, LaPorte MG, Wipf P, Huryn DM, Grandis JR. HCS Campaign to Identify Selective Inhibitors of IL-6-Induced STAT3 Pathway Activation in Head and Neck Cancer Cell Lines. Assay and Drug Development Technologies. 13: 356-76. PMID 26317883 DOI: 10.1089/adt.2015.663  0.4
2015 Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T, Lu P, Brodsky JL, Hackam DJ. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Letters. 56: 3097-3100. PMID 26236050 DOI: 10.1016/j.tetlet.2014.11.048  0.56
2015 Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells. Bioorganic & Medicinal Chemistry Letters. PMID 26159482 DOI: 10.1016/j.bmcl.2015.06.073  0.6
2015 Wissel G, Kudryavtsev P, Ghemtio L, Tammela P, Wipf P, Yliperttula M, Finel M, Urtti A, Kidron H, Xhaard H. Exploring the structure-activity relationships of ABCC2 modulators using a screening approach. Bioorganic & Medicinal Chemistry. 23: 3513-25. PMID 25935289 DOI: 10.1016/j.bmc.2015.04.029  1
2015 Walczak MA, Krainz T, Wipf P. Ring-strain-enabled reaction discovery: new heterocycles from bicyclo[1.1.0]butanes. Accounts of Chemical Research. 48: 1149-58. PMID 25775119 DOI: 10.1021/ar500437h  1
2015 Posimo JM, Weilnau JN, Gleixner AM, Broeren MT, Weiland NL, Brodsky JL, Wipf P, Leak RK. Heat shock protein defenses in the neocortex and allocortex of the telencephalon. Neurobiology of Aging. 36: 1924-37. PMID 25771395 DOI: 10.1016/j.neurobiolaging.2015.02.011  1
2015 Tandon M, Salamoun JM, Carder EJ, Farber E, Xu S, Deng F, Tang H, Wipf P, Wang QJ. SD-208, a novel protein kinase D inhibitor, blocks prostate cancer cell proliferation and tumor growth in vivo by inducing G2/M cell cycle arrest. Plos One. 10: e0119346. PMID 25747583 DOI: 10.1371/journal.pone.0119346  1
2015 George Rosenker KM, Paquette WD, Johnston PA, Sharlow ER, Vogt A, Bakan A, Lazo JS, Wipf P. Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B. Bioorganic & Medicinal Chemistry. 23: 2810-8. PMID 25703307 DOI: 10.1016/j.bmc.2015.01.043  1
2015 Crum TS, Gleixner AM, Posimo JM, Mason DM, Broeren MT, Heinemann SD, Wipf P, Brodsky JL, Leak RK. Heat shock protein responses to aging and proteotoxicity in the olfactory bulb. Journal of Neurochemistry. 133: 780-94. PMID 25640060 DOI: 10.1111/jnc.13041  1
2015 Qian W, Salamoun J, Wang J, Roginskaya V, Van Houten B, Wipf P. The combination of thioxodihydroquinazolinones and platinum drugs reverses platinum resistance in tumor cells by inducing mitochondrial apoptosis independent of Bax and Bak. Bioorganic & Medicinal Chemistry Letters. 25: 856-63. PMID 25582599 DOI: 10.1016/j.bmcl.2014.12.072  1
2015 Wei N, Chu E, Wu SY, Wipf P, Schmitz JC. The cytotoxic effects of regorafenib in combination with protein kinase D inhibition in human colorectal cancer cells. Oncotarget. 6: 4745-56. PMID 25544765 DOI: 10.18632/oncotarget.2938  1
2015 Ji J, Baart S, Vikulina AS, Clark RS, Anthonymuthu TS, Tyurin VA, Du L, St Croix CM, Tyurina YY, Lewis J, Skoda EM, Kline AE, Kochanek PM, Wipf P, Kagan VE, et al. Deciphering of mitochondrial cardiolipin oxidative signaling in cerebral ischemia-reperfusion. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 319-28. PMID 25407268 DOI: 10.1038/jcbfm.2014.204  1
2015 Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, Laporte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 Acs Medicinal Chemistry Letters. 6: 1225-1230. DOI: 10.1021/acsmedchemlett.5b00364  1
2015 Brito GA, Sarotti AM, Wipf P, Pilli RA. Cascade cyclization triggered by imine formation. Formal synthesis of the alkaloid (±)-stemoamide and its 9a-epimer Tetrahedron Letters. 56: 6664-6668. DOI: 10.1016/j.tetlet.2015.10.017  0.4
2015 Wipf P, Eyer BR, Yamaguchi Y, Zhang F, Neal MD, Sodhi CP, Good M, Branca M, Prindle T, Lu P, Brodsky JL, Hackam DJ. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4) Tetrahedron Letters. 56: 3097-3100. DOI: 10.1016/j.tetlet.2014.11.048  1
2015 Ma J, Lim C, Sacher JR, Van Houten B, Qian W, Wipf P. Mitochondrial targeted β-lapachone induces mitochondrial dysfunction and catastrophic vacuolization in cancer cells Bioorganic and Medicinal Chemistry Letters. DOI: 10.1016/j.bmcl.2015.06.073  1
2015 Wipf P, Skoda EM, Mann A. Conformational Restriction and Steric Hindrance in Medicinal Chemistry The Practice of Medicinal Chemistry: Fourth Edition. 279-299. DOI: 10.1016/B978-0-12-417205-0.00011-0  0.4
2015 Greenberger JS, Epperly MW, Wipf P, Li S, Kagan V, Gao X. Gene therapy for mucositis Genomics, Personalized Medicine and Oral Disease. 345-362. DOI: 10.1007/978-3-319-17942-1_16  0.4
2014 Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. Journal of Molecular and Cellular Cardiology. 77: 136-46. PMID 25451170 DOI: 10.1016/j.yjmcc.2014.10.009  1
2014 Ireland AW, Gobillot TA, Gupta T, Seguin SP, Liang M, Resnick L, Goldberg MT, Manos-Turvey A, Pipas JM, Wipf P, Brodsky JL. Synthesis and structure–activity relationships of small molecule inhibitors of the simian virus 40 T antigen oncoprotein, an anti-polyomaviral target. Bioorganic & Medicinal Chemistry. 22: 6490-502. PMID 25440730 DOI: 10.1016/j.bmc.2014.09.019  1
2014 LaPorte MG, da Paz Lima DJ, Zhang F, Sen M, Grandis JR, Camarco D, Hua Y, Johnston PA, Lazo JS, Resnick LO, Wipf P, Huryn DM. 2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway. Bioorganic & Medicinal Chemistry Letters. 24: 5081-5. PMID 25288188 DOI: 10.1016/j.bmcl.2014.09.001  1
2014 Busacca CA, Milligan JA, Rattanangkool E, Ramavarapu C, Chen A, Saha AK, Li Z, Lee H, Geib SJ, Wang G, Senanayake CH, Wipf P. Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes. The Journal of Organic Chemistry. 79: 9878-87. PMID 25271367 DOI: 10.1021/jo501841s  1
2014 Tarr TB, Wipf P, Meriney SD. Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome. Molecular Neurobiology. PMID 25195700 DOI: 10.1007/s12035-014-8887-2  1
2014 Shinde A, Epperly MW, Cao S, Holt D, Goff J, Shields D, Franicola D, Wipf P, Wang H, Greenberger JS. Improved hematopoiesis in GS-nitroxide (JP4-039)-treated mouse long-term bone marrow cultures and radioresistance of derived bone marrow stromal cell lines. In Vivo (Athens, Greece). 28: 699-708. PMID 25189880  1
2014 Skoda EM, Sacher JR, Kazancioglu MZ, Saha J, Wipf P. An uncharged oxetanyl sulfoxide as a covalent modifier for improving aqueous solubility. Acs Medicinal Chemistry Letters. 5: 900-4. PMID 25147611 DOI: 10.1021/ml5001504  1
2014 Tarr TB, Lacomis D, Reddel SW, Liang M, Valdomir G, Frasso M, Wipf P, Meriney SD. Complete reversal of Lambert-Eaton myasthenic syndrome synaptic impairment by the combined use of a K+ channel blocker and a Ca2+ channel agonist. The Journal of Physiology. 592: 3687-96. PMID 25015919 DOI: 10.1113/jphysiol.2014.276493  1
2014 Shinde A, Epperly MW, Cao S, Franicola D, Shields D, Wang H, Wipf P, Sprachman MM, Greenberger JS. Effects of the bifunctional sulfoxide MMS350, a radiation mitigator, on hematopoiesis in long-term bone marrow cultures and on radioresistance of marrow stromal cell lines. In Vivo (Athens, Greece). 28: 457-65. PMID 24982210  1
2014 Epperly MW, Goff JP, Franicola D, Wang H, Wipf P, Li S, Greenberger JS. Esophageal radioprotection by swallowed JP4-039/F15 in thoracic-irradiated mice with transgenic lung tumors. In Vivo (Athens, Greece). 28: 435-40. PMID 24982207  1
2014 Berhane H, Shinde A, Kalash R, Xu K, Epperly MW, Goff J, Franicola D, Zhang X, Dixon T, Shields D, Wang H, Wipf P, Li S, Gao X, Greenberger JS. Amelioration of radiation-induced oral cavity mucositis and distant bone marrow suppression in fanconi anemia Fancd2-/- (FVB/N) mice by intraoral GS-nitroxide JP4-039. Radiation Research. 182: 35-49. PMID 24932534 DOI: 10.1667/RR13633.1  1
2014 Adam C, Baeurle A, Brodsky JL, Wipf P, Schrama D, Becker JC, Houben R. The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma. Plos One. 9: e92041. PMID 24694787 DOI: 10.1371/journal.pone.0092041  1
2014 Salamoun J, Anderson S, Burnett JC, Gussio R, Wipf P. Synthesis of heterocyclic triads by Pd-catalyzed cross-couplings and evaluation of their cell-specific toxicity profile. Organic Letters. 16: 2034-7. PMID 24641272 DOI: 10.1021/ol500620m  1
2014 Wei N, Chu E, Wipf P, Schmitz JC. Protein kinase d as a potential chemotherapeutic target for colorectal cancer. Molecular Cancer Therapeutics. 13: 1130-41. PMID 24634417 DOI: 10.1158/1535-7163.MCT-13-0880  1
2014 Sharlow ER, Wipf P, McQueeney KE, Bakan A, Lazo JS. Investigational inhibitors of PTP4A3 phosphatase as antineoplastic agents. Expert Opinion On Investigational Drugs. 23: 661-73. PMID 24625356 DOI: 10.1517/13543784.2014.892579  1
2014 Greenberger JS, Berhane H, Shinde A, Rhieu BH, Bernard M, Wipf P, Skoda EM, Epperly MW. Can Radiosensitivity Associated with Defects in DNA Repair be Overcome by Mitochondrial-Targeted Antioxidant Radioprotectors. Frontiers in Oncology. 4: 24. PMID 24596683 DOI: 10.3389/fonc.2014.00024  1
2014 Kanter DJ, O'Brien MB, Shi XH, Chu T, Mishima T, Beriwal S, Epperly MW, Wipf P, Greenberger JS, Sadovsky Y. The impact of ionizing radiation on placental trophoblasts. Placenta. 35: 85-91. PMID 24418702 DOI: 10.1016/j.placenta.2013.12.011  1
2014 Berhane H, Epperly MW, Goff J, Kalash R, Cao S, Franicola D, Zhang X, Shields D, Houghton F, Wang H, Wipf P, Parmar K, Greenberger JS. Radiologic differences between bone marrow stromal and hematopoietic progenitor cell lines from Fanconi Anemia (Fancd2(-/-)) mice. Radiation Research. 181: 76-89. PMID 24397476 DOI: 10.1667/RR13405.1  1
2014 Faral-Tello P, Liang M, Mahler G, Wipf P, Robello C. Imidazolium compounds are active against all stages of Trypanosoma cruzi. International Journal of Antimicrobial Agents. 43: 262-8. PMID 24359836 DOI: 10.1016/j.ijantimicag.2013.10.019  1
2014 Antony ML, Lee J, Hahm ER, Kim SH, Marcus AI, Kumari V, Ji X, Yang Z, Vowell CL, Wipf P, Uechi GT, Yates NA, Romero G, Sarkar SN, Singh SV. Growth arrest by the antitumor steroidal lactone withaferin A in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin. The Journal of Biological Chemistry. 289: 1852-65. PMID 24297176 DOI: 10.1074/jbc.M113.496844  1
2014 Colombo R, Jeon KO, Huryn DM, LaPorte MG, Wipf P. A new synthesis of 4,5,6,7-Tetrahydropyrazolo[1,5-c] pyrimidines by a retro-mannich cascade rearrangement Australian Journal of Chemistry. 67: 420-425. DOI: 10.1071/CH13468  1
2014 Schuster EM, Wipf P. Special issue: Flow chemistry Israel Journal of Chemistry. 54: 340. DOI: 10.1002/ijch.201410005  1
2014 Schuster EM, Wipf P. Photochemical flow reactions Israel Journal of Chemistry. 54: 361-370. DOI: 10.1002/ijch.201400045  1
2013 Cifuentes-Pagano E, Saha J, Csányi G, Ghouleh IA, Sahoo S, Rodríguez A, Wipf P, Pagano PJ, Skoda EM. Bridged tetrahydroisoquinolines as selective NADPH oxidase 2 (Nox2) inhibitors. Medchemcomm. 4: 1085-1092. PMID 24466406 DOI: 10.1039/C3MD00061C  1
2013 Kalash R, Epperly MW, Goff J, Dixon T, Sprachman MM, Zhang X, Shields D, Cao S, Franicola D, Wipf P, Berhane H, Wang H, Au J, Greenberger JS. Amelioration of radiation-induced pulmonary fibrosis by a water-soluble bifunctional sulfoxide radiation mitigator (MMS350). Radiation Research. 180: 474-90. PMID 24125487 DOI: 10.1667/RR3233.1  1
2013 Tandon M, Johnson J, Li Z, Xu S, Wipf P, Wang QJ. New pyrazolopyrimidine inhibitors of protein kinase d as potent anticancer agents for prostate cancer cells. Plos One. 8: e75601. PMID 24086585 DOI: 10.1371/journal.pone.0075601  1
2013 Lazo JS, Sharlow ER, Epperly MW, Lira A, Leimgruber S, Skoda EM, Wipf P, Greenberger JS. Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death. The Journal of Pharmacology and Experimental Therapeutics. 347: 669-80. PMID 24068833 DOI: 10.1124/jpet.113.208421  1
2013 Arnold DM, Laporte MG, Anderson SM, Wipf P. Condensation reactions of guanidines with bis-electrophiles: Formation of highly nitrogenous heterocycles. Tetrahedron. 69: 7719-7731. PMID 23976798 DOI: 10.1016/j.tet.2013.04.127  1
2013 Goff JP, Shields DS, Wang H, Skoda EM, Sprachman MM, Wipf P, Garapati VK, Atkinson J, London B, Lazo JS, Kagan V, Epperly MW, Greenberger JS. Evaluation of potential ionizing irradiation protectors and mitigators using clonogenic survival of human umbilical cord blood hematopoietic progenitor cells. Experimental Hematology. 41: 957-66. PMID 23933481 DOI: 10.1016/j.exphem.2013.08.001  1
2013 Keffer JL, Huecas S, Hammill JT, Wipf P, Andreu JM, Bewley CA. Chrysophaentins are competitive inhibitors of FtsZ and inhibit Z-ring formation in live bacteria. Bioorganic & Medicinal Chemistry. 21: 5673-8. PMID 23932448 DOI: 10.1016/j.bmc.2013.07.033  1
2013 Nesbitt KM, Jaquins-Gerstl A, Skoda EM, Wipf P, Michael AC. Pharmacological mitigation of tissue damage during brain microdialysis. Analytical Chemistry. 85: 8173-9. PMID 23927692 DOI: 10.1021/ac401201x  1
2013 Tarr TB, Malick W, Liang M, Valdomir G, Frasso M, Lacomis D, Reddel SW, Garcia-Ocano A, Wipf P, Meriney SD. Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10559-67. PMID 23785168 DOI: 10.1523/JNEUROSCI.4629-12.2013  1
2013 Neal MD, Jia H, Eyer B, Good M, Guerriero CJ, Sodhi CP, Afrazi A, Prindle T, Ma C, Branca M, Ozolek J, Brodsky JL, Wipf P, Hackam DJ. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. Plos One. 8: e65779. PMID 23776545 DOI: 10.1371/journal.pone.0065779  1
2013 Frantz MC, Skoda EM, Sacher JR, Epperly MW, Goff JP, Greenberger JS, Wipf P. Synthesis of analogs of the radiation mitigator JP4-039 and visualization of BODIPY derivatives in mitochondria. Organic & Biomolecular Chemistry. 11: 4147-53. PMID 23715589 DOI: 10.1039/c3ob40489g  1
2013 Huryn DM, Resnick LO, Wipf P. Contributions of academic laboratories to the discovery and development of chemical biology tools. Journal of Medicinal Chemistry. 56: 7161-76. PMID 23672690 DOI: 10.1021/jm400132d  1
2013 Kalash R, Berhane H, Goff J, Houghton F, Epperly MW, Dixon T, Zhang X, Sprachman MM, Wipf P, Franicola D, Wang H, Greenberger JS. Effects of thoracic irradiation on pulmonary endothelial compared to alveolar type-II cells in fibrosis-prone C57BL/6NTac mice. In Vivo (Athens, Greece). 27: 291-7. PMID 23606683  1
2013 Kilpatrick K, Novoa JA, Hancock T, Guerriero CJ, Wipf P, Brodsky JL, Segatori L. Chemical induction of Hsp70 reduces α-synuclein aggregation in neuroglioma cells. Acs Chemical Biology. 8: 1460-8. PMID 23594135 DOI: 10.1021/cb400017h  1
2013 Virshup AM, Contreras-García J, Wipf P, Yang W, Beratan DN. Stochastic voyages into uncharted chemical space produce a representative library of all possible drug-like compounds. Journal of the American Chemical Society. 135: 7296-303. PMID 23548177 DOI: 10.1021/ja401184g  1
2013 Busacca CA, Qu B, Farber E, Haddad N, Gr?t N, Saha AK, Eriksson MC, Wu JP, Fandrick KR, Han S, Grinberg N, Ma S, Lee H, Li Z, Spinelli M, ... ... Wipf P, et al. Hydrophosphination of propargylic alcohols and amines with phosphine boranes. Organic Letters. 15: 1132-5. PMID 23427869 DOI: 10.1021/ol400309y  1
2013 Busacca CA, Qu B, Farber E, Haddad N, Gr?t N, Saha AK, Eriksson MC, Wu JP, Fandrick KR, Han S, Grinberg N, Ma S, Lee H, Li Z, Spinelli M, ... ... Wipf P, et al. [2,3]-Sigmatropic rearrangements of 2-phosphineborane 2-propen-1-ols: rapid access to enantioenriched diphosphine monoxide derivatives. Organic Letters. 15: 1136-9. PMID 23427861 DOI: 10.1021/ol400310h  1
2013 Rosenker CJ, Krenske EH, Houk KN, Wipf P. Influence of base and structure in the reversible covalent conjugate addition of thiol to polycyclic enone scaffolds. Organic Letters. 15: 1076-9. PMID 23405884 DOI: 10.1021/ol400094k  1
2013 Nasto LA, Robinson AR, Ngo K, Clauson CL, Dong Q, St Croix C, Sowa G, Pola E, Robbins PD, Kang J, Niedernhofer LJ, Wipf P, Vo NV. Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 31: 1150-7. PMID 23389888 DOI: 10.1002/jor.22320  1
2013 Wang L, Ma C, Wipf P, Liu H, Su W, Xie XQ. TargetHunter: an in silico target identification tool for predicting therapeutic potential of small organic molecules based on chemogenomic database. The Aaps Journal. 15: 395-406. PMID 23292636 DOI: 10.1208/s12248-012-9449-z  1
2013 Gao X, Huang Y, Makhov AM, Epperly M, Lu J, Grab S, Zhang P, Rohan L, Xie XQ, Wipf P, Greenberger J, Li S. Nanoassembly of surfactants with interfacial drug-interactive motifs as tailor-designed drug carriers. Molecular Pharmaceutics. 10: 187-98. PMID 23244299 DOI: 10.1021/mp300319m  1
2013 LaPorte M, Hong KB, Xu J, Wipf P. 5-Hydroxyindoles by intramolecular alkynol-furan diels-alder cycloaddition. The Journal of Organic Chemistry. 78: 167-74. PMID 23136970 DOI: 10.1021/jo3022605  1
2013 Guo J, Clausen DM, Beumer JH, Parise RA, Egorin MJ, Bravo-Altamirano K, Wipf P, Sharlow ER, Wang QJ, Eiseman JL. In vitro cytotoxicity, pharmacokinetics, tissue distribution, and metabolism of small-molecule protein kinase D inhibitors, kb-NB142-70 and kb-NB165-09, in mice bearing human cancer xenografts. Cancer Chemotherapy and Pharmacology. 71: 331-44. PMID 23108699 DOI: 10.1007/s00280-012-2010-z  1
2013 Wipf P, Fang Z, Ferrié L, Ueda M, Walczak MAA, Yan Y, Yang M. Cycloadditions in heterocycle and alkaloid synthesis Pure and Applied Chemistry. 85: 1079-1087. DOI: 10.1351/PAC-CON-12-09-03  1
2013 Sasmal A, Taniguchi T, Wipf P, Curran DP. Memory of chirality in rebound cyclizations of α-amide radicals Canadian Journal of Chemistry. 91: 1-5. DOI: 10.1139/v2012-085  1
2013 Huryn DM, Wipf P. Natural Product Chemistry and Cancer Drug Discovery Cancer Drug Design and Discovery: Second Edition. 91-120. DOI: 10.1016/B978-0-12-396521-9.00003-6  1
2012 Wang L, Ma C, Wipf P, Xie XQ. Linear and Nonlinear Support Vector Machine for the Classification of Human 5-HT1A Ligand Functionality. Molecular Informatics. 31: 85-95. PMID 27478180 DOI: 10.1002/minf.201100126  0.68
2012 Liang M, Tarr TB, Bravo-Altamirano K, Valdomir G, Rensch G, Swanson L, DeStefino NR, Mazzarisi CM, Olszewski RA, Wilson GM, Meriney SD, Wipf P. Synthesis and biological evaluation of a selective N- and p/q-type calcium channel agonist. Acs Medicinal Chemistry Letters. 3: 985-90. PMID 24936234 DOI: 10.1021/ml3002083  1
2012 Tarr TB, Valdomir G, Liang M, Wipf P, Meriney SD. New calcium channel agonists as potential therapeutics in Lambert-Eaton myasthenic syndrome and other neuromuscular diseases. Annals of the New York Academy of Sciences. 1275: 85-91. PMID 23278582 DOI: 10.1111/nyas.12001  1
2012 Xun Z, Rivera-Sánchez S, Ayala-Peña S, Lim J, Budworth H, Skoda EM, Robbins PD, Niedernhofer LJ, Wipf P, McMurray CT. Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Reports. 2: 1137-42. PMID 23122961 DOI: 10.1016/j.celrep.2012.10.001  1
2012 Tandon M, Wang L, Xu Q, Xie X, Wipf P, Wang QJ. A targeted library screen reveals a new inhibitor scaffold for protein kinase D. Plos One. 7: e44653. PMID 23028574 DOI: 10.1371/journal.pone.0044653  1
2012 Miller B, Mao S, Rosenker KM, Pierce JG, Wipf P. Synthesis of a library of tricyclic azepinoisoindolinones. Beilstein Journal of Organic Chemistry. 8: 1091-7. PMID 23019435 DOI: 10.3762/bjoc.8.120  1
2012 McCarthy JG, Eisman EB, Kulkarni S, Gerwick L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Structural basis of functional group activation by sulfotransferases in complex metabolic pathways. Acs Chemical Biology. 7: 1994-2003. PMID 22991895 DOI: 10.1021/cb300385m  1
2012 Lu D, Chambers P, Wipf P, Xie XQ, Englert D, Weber S. Lipophilicity screening of novel drug-like compounds and comparison to clog P. Journal of Chromatography. A. 1258: 161-7. PMID 22939208 DOI: 10.1016/j.chroma.2012.07.078  1
2012 Ji J, Kline AE, Amoscato A, Samhan-Arias AK, Sparvero LJ, Tyurin VA, Tyurina YY, Fink B, Manole MD, Puccio AM, Okonkwo DO, Cheng JP, Alexander H, Clark RS, Kochanek PM, ... Wipf P, et al. Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury. Nature Neuroscience. 15: 1407-13. PMID 22922784 DOI: 10.1038/nn.3195  1
2012 Seguin SP, Ireland AW, Gupta T, Wright CM, Miyata Y, Wipf P, Pipas JM, Gestwicki JE, Brodsky JL. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Research. 96: 70-81. PMID 22898086 DOI: 10.1016/j.antiviral.2012.07.012  1
2012 Keffer JL, Hammill JT, Lloyd JR, Plaza A, Wipf P, Bewley CA. Geographic variability and anti-staphylococcal activity of the chrysophaentins and their synthetic fragments. Marine Drugs. 10: 1103-25. PMID 22822360 DOI: 10.3390/md10051103  1
2012 Cao L, Maciejewski JP, Elzner S, Amantini D, Wipf P. Synthesis of 1,2,4-triazines and the triazinoisoquinolinedione DEF ring system of noelaquinone. Organic & Biomolecular Chemistry. 10: 5811-4. PMID 22473572 DOI: 10.1039/c2ob25353d  1
2012 Skoda EM, Davis GC, Wipf P. Allylic Amines as Key Building Blocks in the Synthesis of (E)-Alkene Peptide Isosteres. Organic Process Research & Development. 16: 26-34. PMID 22323894 DOI: 10.1021/op2002613  1
2012 Sprachman MM, Wipf P. A bifunctional dimethylsulfoxide substitute enhances the aqueous solubility of small organic molecules. Assay and Drug Development Technologies. 10: 269-77. PMID 22192308 DOI: 10.1089/adt.2011.0421  1
2012 Liu Z, Celotto AM, Romero G, Wipf P, Palladino MJ. Genetically encoded redox sensor identifies the role of ROS in degenerative and mitochondrial disease pathogenesis. Neurobiology of Disease. 45: 362-8. PMID 21889980 DOI: 10.1016/j.nbd.2011.08.022  1
2012 Pizzo C, Faral-Tello P, Salinas G, Fló M, Robello C, Wipf P, Graciela Mahler S. Selenosemicarbazones as potent cruzipain inhibitors and their antiparasitic properties against Trypanosoma cruzi Medchemcomm. 3: 362-368. DOI: 10.1039/c2md00283c  1
2012 Wang L, Ma C, Wipf P, Xie XQ. Linear and nonlinear support vector machine for the classification of human 5-HT 1A ligand functionality Molecular Informatics. 31: 85-95. DOI: 10.1002/minf.201100126  1
2011 Greenberger JS, Clump D, Kagan V, Bayir H, Lazo JS, Wipf P, Li S, Gao X, Epperly MW. Strategies for discovery of small molecule radiation protectors and radiation mitigators. Frontiers in Oncology. 1: 59. PMID 22655254 DOI: 10.3389/fonc.2011.00059  1
2011 George KM, Frantz MC, Bravo-Altamirano K, Lavalle CR, Tandon M, Leimgruber S, Sharlow ER, Lazo JS, Wang QJ, Wipf P. Design, Synthesis, and Biological Evaluation of PKD Inhibitors. Pharmaceutics. 3: 186-228. PMID 22267986 DOI: 10.3390/pharmaceutics3020186  1
2011 Kim H, Bernard ME, Epperly MW, Shen H, Amoscato A, Dixon TM, Doemling AS, Li S, Gao X, Wipf P, Wang H, Zhang X, Kagan VE, Greenberger JS. Amelioration of radiation esophagitis by orally administered p53/Mdm2/Mdm4 inhibitor (BEB55) or GS-nitroxide. In Vivo (Athens, Greece). 25: 841-8. PMID 22021675  1
2011 Sharlow ER, Mustata Wilson G, Close D, Leimgruber S, Tandon M, Reed RB, Shun TY, Wang QJ, Wipf P, Lazo JS. Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. Plos One. 6: e25134. PMID 21998636 DOI: 10.1371/journal.pone.0025134  1
2011 Braunstein MJ, Scott SS, Scott CM, Behrman S, Walter P, Wipf P, Coplan JD, Chrico W, Joseph D, Brodsky JL, Batuman O. Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101. Journal of Oncology. 2011: 232037. PMID 21977030 DOI: 10.1155/2011/232037  1
2011 Bernard ME, Kim H, Berhane H, Epperly MW, Franicola D, Zhang X, Houghton F, Shields D, Wang H, Bakkenist CJ, Frantz MC, Forbeck EM, Goff JP, Wipf P, Greenberger JS. GS-nitroxide (JP4-039)-mediated radioprotection of human Fanconi anemia cell lines. Radiation Research. 176: 603-12. PMID 21939290 DOI: 10.1016/j.ijrobp.2011.06.1288  1
2011 Milner E, Gardner S, Moon J, Grauer K, Auschwitz J, Bathurst I, Caridha D, Gerena L, Gettayacamin M, Johnson J, Kozar M, Lee P, Leed S, Li Q, McCalmont W, ... ... Wipf P, et al. Structure-activity relationships of 4-position diamine quinoline methanols as intermittent preventative treatment (IPT) against Plasmodium falciparum. Journal of Medicinal Chemistry. 54: 6277-85. PMID 21854078 DOI: 10.1021/jm200647u  1
2011 Wipf P, Manojlovic MD. Homoallylic amines by reductive inter- and intramolecular coupling of allenes and nitriles. Beilstein Journal of Organic Chemistry. 7: 824-30. PMID 21804878 DOI: 10.3762/bjoc.7.94  1
2011 Hopkins CD, Schmitz JC, Chu E, Wipf P. Total synthesis of (-)-CP2-disorazole C1. Organic Letters. 13: 4088-91. PMID 21739942 DOI: 10.1021/ol2015994  1
2011 Saiz C, Wipf P, Mahler G. Synthesis and ring-chain-ring tautomerism of bisoxazolidines, thiazolidinyloxazolidines, and spirothiazolidines. The Journal of Organic Chemistry. 76: 5738-46. PMID 21634420 DOI: 10.1021/jo2008498  1
2011 Bravo-Altamirano K, George KM, Frantz MC, Lavalle CR, Tandon M, Leimgruber S, Sharlow ER, Lazo JS, Wang QJ, Wipf P. Synthesis and Structure-Activity Relationships of Benzothienothiazepinone Inhibitors of Protein Kinase D. Acs Medicinal Chemistry Letters. 2: 154-159. PMID 21617763 DOI: 10.1021/ml100230n  1
2011 Goff JP, Epperly MW, Dixon T, Wang H, Franicola D, Shields D, Wipf P, Li S, Gao X, Greenberger JS. Radiobiologic effects of GS-nitroxide (JP4-039) on the hematopoietic syndrome. In Vivo (Athens, Greece). 25: 315-23. PMID 21576404  1
2011 Zaware N, Laporte MG, Farid R, Liu L, Wipf P, Floreancig PE. Diversity-oriented synthesis of a library of substituted tetrahydropyrones using oxidative carbon-hydrogen bond activation and click chemistry. Molecules (Basel, Switzerland). 16: 3648-62. PMID 21540794 DOI: 10.3390/molecules16053648  1
2011 Petronijevic FR, Wipf P. Total synthesis of (±)-cycloclavine and (±)-5-epi-cycloclavine. Journal of the American Chemical Society. 133: 7704-7. PMID 21517102 DOI: 10.1021/ja2026882  1
2011 Hoye AT, Wipf P. Total synthesis of (-)-sessilifoliamide C and (-)-8-epi-stemoamide. Organic Letters. 13: 2634-7. PMID 21510628 DOI: 10.1021/ol200743u  1
2011 Huryn DM, Brodsky JL, Brummond KM, Chambers PG, Eyer B, Ireland AW, Kawasumi M, Laporte MG, Lloyd K, Manteau B, Nghiem P, Quade B, Seguin SP, Wipf P. Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators. Proceedings of the National Academy of Sciences of the United States of America. 108: 6757-62. PMID 21502524 DOI: 10.1073/pnas.1015251108  1
2011 Rwigema JC, Beck B, Wang W, Doemling A, Epperly MW, Shields D, Goff JP, Franicola D, Dixon T, Frantz MC, Wipf P, Tyurina Y, Kagan VE, Wang H, Greenberger JS. Two strategies for the development of mitochondrion-targeted small molecule radiation damage mitigators. International Journal of Radiation Oncology, Biology, Physics. 80: 860-8. PMID 21493014 DOI: 10.1016/j.ijrobp.2011.01.059  1
2011 Frantz MC, Pierce JG, Pierce JM, Kangying L, Qingwei W, Johnson M, Wipf P. Large-scale asymmetric synthesis of the bioprotective agent JP4-039 and analogs. Organic Letters. 13: 2318-21. PMID 21452836 DOI: 10.1021/ol200567p  1
2011 Wang L, Xie Z, Wipf P, Xie XQ. Residue preference mapping of ligand fragments in the Protein Data Bank. Journal of Chemical Information and Modeling. 51: 807-15. PMID 21417260 DOI: 10.1021/ci100386y  1
2011 Gehret JJ, Gu L, Gerwick WH, Wipf P, Sherman DH, Smith JL. Terminal alkene formation by the thioesterase of curacin A biosynthesis: structure of a decarboxylating thioesterase. The Journal of Biological Chemistry. 286: 14445-54. PMID 21357626 DOI: 10.1074/jbc.M110.214635  1
2011 Pizzo C, Saiz C, Talevi A, Gavernet L, Palestro P, Bellera C, Blanch LB, Benítez D, Cazzulo JJ, Chidichimo A, Wipf P, Mahler SG. Synthesis of 2-hydrazolyl-4-thiazolidinones based on multicomponent reactions and biological evaluation against Trypanosoma Cruzi. Chemical Biology & Drug Design. 77: 166-72. PMID 21251233 DOI: 10.1111/j.1747-0285.2010.01071.x  1
2011 Botha M, Chiang AN, Needham PG, Stephens LL, Hoppe HC, Külzer S, Przyborski JM, Lingelbach K, Wipf P, Brodsky JL, Shonhai A, Blatch GL. Plasmodium falciparum encodes a single cytosolic type I Hsp40 that functionally interacts with Hsp70 and is upregulated by heat shock. Cell Stress & Chaperones. 16: 389-401. PMID 21191678 DOI: 10.1007/s12192-010-0250-6  1
2011 MacIejewski JP, Wipf P. Titanocene(III)-catalyzed conversion of N-(epoxyalkyl)anilines into indolines Arkivoc. 2011: 92-119. DOI: 10.3998/ark.5550190.0012.609  1
2010 Epperly MW, Goff JP, Li S, Gao X, Wipf P, Dixon T, Wang H, Franicola D, Shen H, Rwigema JC, Kagan V, Bernard M, Greenberger JS. Intraesophageal administration of GS-nitroxide (JP4-039) protects against ionizing irradiation-induced esophagitis. In Vivo (Athens, Greece). 24: 811-9. PMID 21164038  1
2010 Wipf P, George KM. Regioselective Palladium-Catalyzed Cross-Coupling Reactions of 2,4,7-Trichloroquinazoline. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 2010: 644-648. PMID 21116479 DOI: 10.1055/s-0029-1219391  1
2010 Nuss JE, Dong Y, Wanner LM, Ruthel G, Wipf P, Gussio R, Vennerstrom JL, Bavari S, Burnett JC. Pharmacophore Refinement Guides the Rational Design of Nanomolar-Range Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease. Acs Medicinal Chemistry Letters. 1: 301-305. PMID 21116458 DOI: 10.1021/ml100056v  1
2010 Wang XJ, Zhang L, Krishnamurthy D, Senanayake CH, Wipf P. General solution to the synthesis of N-2-substituted 1,2,3-triazoles. Organic Letters. 12: 4632-5. PMID 20863126 DOI: 10.1021/ol101965a  1
2010 Hammill JT, Contreras-García J, Virshup AM, Beratan D, Yang W, Wipf P. Synthesis and chemical diversity analysis of bicyclo[3.3.1]non-3-en-2-ones. Tetrahedron. 66: 5852-5862. PMID 20798897 DOI: 10.1016/j.tet.2010.04.112  1
2010 Gokhale A, Rwigema JC, Epperly MW, Glowacki J, Wang H, Wipf P, Goff JP, Dixon T, Patrene K, Greenberger JS. Small molecule GS-nitroxide ameliorates ionizing irradiation-induced delay in bone wound healing in a novel murine model. In Vivo (Athens, Greece). 24: 377-85. PMID 20668303  1
2010 Mishra JK, Wipf P, Sinha SC. Studies toward a library of tetrahydrofurans: click and MCR products of mono- and bis-tetrahydrofurans. Journal of Combinatorial Chemistry. 12: 609-12. PMID 20614864 DOI: 10.1021/cc1000709  1
2010 Zuniga JE, Hammill JT, Drory O, Nuss JE, Burnett JC, Gussio R, Wipf P, Bavari S, Brunger AT. Iterative structure-based peptide-like inhibitor design against the botulinum neurotoxin serotype A. Plos One. 5: e11378. PMID 20614028 DOI: 10.1371/journal.pone.0011378  1
2010 LaValle CR, George KM, Sharlow ER, Lazo JS, Wipf P, Wang QJ. Protein kinase D as a potential new target for cancer therapy. Biochimica Et Biophysica Acta. 1806: 183-92. PMID 20580776 DOI: 10.1016/j.bbcan.2010.05.003  1
2010 Wisén S, Bertelsen EB, Thompson AD, Patury S, Ung P, Chang L, Evans CG, Walter GM, Wipf P, Carlson HA, Brodsky JL, Zuiderweg ER, Gestwicki JE. Binding of a small molecule at a protein-protein interface regulates the chaperone activity of hsp70-hsp40. Acs Chemical Biology. 5: 611-22. PMID 20481474 DOI: 10.1021/cb1000422  1
2010 Lavalle CR, Bravo-Altamirano K, Giridhar KV, Chen J, Sharlow E, Lazo JS, Wipf P, Wang QJ. Novel protein kinase D inhibitors cause potent arrest in prostate cancer cell growth and motility. Bmc Chemical Biology. 10: 5. PMID 20444281 DOI: 10.1186/1472-6769-10-5  1
2010 Tyurina YY, Tyurin VA, Kaynar AM, Kapralova VI, Wasserloos K, Li J, Mosher M, Wright L, Wipf P, Watkins S, Pitt BR, Kagan VE. Oxidative lipidomics of hyperoxic acute lung injury: mass spectrometric characterization of cardiolipin and phosphatidylserine peroxidation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 299: L73-85. PMID 20418384 DOI: 10.1152/ajplung.00035.2010  1
2010 Xu FL, Rbaibi Y, Kiselyov K, Lazo JS, Wipf P, Saunders WS. Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1. Bmc Chemical Biology. 10: 1. PMID 20181182 DOI: 10.1186/1472-6769-10-1  1
2010 Frantz MC, Wipf P. Mitochondria as a target in treatment. Environmental and Molecular Mutagenesis. 51: 462-75. PMID 20175113 DOI: 10.1002/em.20554  1
2010 Milner E, McCalmont W, Bhonsle J, Caridha D, Cobar J, Gardner S, Gerena L, Goodine D, Lanteri C, Melendez V, Roncal N, Sousa J, Wipf P, Dow GS. Anti-malarial activity of a non-piperidine library of next-generation quinoline methanols. Malaria Journal. 9: 51. PMID 20149249 DOI: 10.1186/1475-2875-9-51  1
2010 Epperly MW, Franicola D, Shields D, Rwigema JC, Stone B, Zhang X, McBride W, Georges G, Wipf P, Greenberger JS. Screening of antimicrobial agents for in vitro radiation protection and mitigation capacity, including those used in supportive care regimens for bone marrow transplant recipients. In Vivo (Athens, Greece). 24: 9-19. PMID 20133970  1
2010 Milner E, McCalmont W, Bhonsle J, Caridha D, Carroll D, Gardner S, Gerena L, Gettayacamin M, Lanteri C, Luong T, Melendez V, Moon J, Roncal N, Sousa J, Tungtaeng A, ... Wipf P, et al. Structure-activity relationships amongst 4-position quinoline methanol antimalarials that inhibit the growth of drug sensitive and resistant strains of Plasmodium falciparum. Bioorganic & Medicinal Chemistry Letters. 20: 1347-51. PMID 20097070 DOI: 10.1016/j.bmcl.2010.01.001  1
2010 Soares KM, Blackmon N, Shun TY, Shinde SN, Takyi HK, Wipf P, Lazo JS, Johnston PA. Profiling the NIH Small Molecule Repository for compounds that generate H2O2 by redox cycling in reducing environments. Assay and Drug Development Technologies. 8: 152-74. PMID 20070233 DOI: 10.1089/adt.2009.0247  1
2010 Lazo JS, Reese CE, Vogt A, Vollmer LL, Kitchens CA, Günther E, Graham TH, Hopkins CD, Wipf P. Identifying a resistance determinant for the antimitotic natural products disorazole C1 and A1. The Journal of Pharmacology and Experimental Therapeutics. 332: 906-11. PMID 20008956 DOI: 10.1124/jpet.109.162842  1
2010 Mo T, Mi X, Milner EE, Dow GS, Wipf P. Synthesis of an 8-pentafluorosulfanyl analog of the antimalarial agent mefloquine Tetrahedron Letters. 51: 5137-5140. DOI: 10.1016/j.tetlet.2010.07.113  1
2010 Kirai N, Yamamoto Y, Wipf P, Vowell CL. Stereoselective synthesis of 3-arylacrylates by copper-catalyzed syn hydroarylation [(E)-methyl 3-phenyloct-2-enoate] Organic Syntheses. 87: 53-58.  1
2010 Zhao B, Du H, Fu R, Shi Y, Buck EE, Wipf P. Pd(0)-catalyzed asymmetric allylic and homoallylic diamination of 4-phenyl-1-butene with DI-tert-butyldiaziridinone Organic Syntheses. 87: 263-274.  1
2010 Chalker JM, Thompson AL, Davis BG, Zaware N, Wipf P. Safe and scalable preparation of barluenga's reagent: (Bis(pyridine) iodonium(I) tetrafluoroborate) Organic Syntheses. 87: 288-298.  1
2009 Wipf P, Xiao J, Stephenson CR. Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents. Chimia. 63: 764-775. PMID 20725595 DOI: 10.2533/chimia.2009.764  1
2009 Liang M, Saiz C, Pizzo C, Wipf P. Synthesis of pyrrolo[1,3]diazepines by a dipolar cycloaddition - retro-Mannich domino reaction. Tetrahedron Letters. 50: 6810-6813. PMID 20160922 DOI: 10.1016/j.tetlet.2009.09.107  1
2009 Lazo JS, Wipf P. Phosphatases as targets for cancer treatment. Current Opinion in Investigational Drugs (London, England : 2000). 10: 1297-304. PMID 19943201  1
2009 Sharlow ER, Close D, Shun T, Leimgruber S, Reed R, Mustata G, Wipf P, Johnson J, O'Neil M, Grögl M, Magill AJ, Lazo JS. Identification of potent chemotypes targeting Leishmania major using a high-throughput, low-stringency, computationally enhanced, small molecule screen. Plos Neglected Tropical Diseases. 3: e540. PMID 19888337 DOI: 10.1371/journal.pntd.0000540  1
2009 Gu L, Wang B, Kulkarni A, Gehret JJ, Lloyd KR, Gerwick L, Gerwick WH, Wipf P, HÃ¥kansson K, Smith JL, Sherman DH. Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. Journal of the American Chemical Society. 131: 16033-5. PMID 19835378 DOI: 10.1021/ja9071578  1
2009 Wipf P, Arnold D, Carter K, Dong S, Johnston PA, Sharlow E, Lazo JS, Huryn D. A case study from the chemistry core of the Pittsburgh Molecular Library Screening Center: the Polo-like kinase polo-box domain (Plk1-PBD). Current Topics in Medicinal Chemistry. 9: 1194-205. PMID 19807663 DOI: 10.2174/156802609789753590  1
2009 Wipf P, Mo T, Geib SJ, Caridha D, Dow GS, Gerena L, Roncal N, Milner EE. Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine. Organic & Biomolecular Chemistry. 7: 4163-5. PMID 19795052 DOI: 10.1039/b911483a  1
2009 Rajagopalan MS, Gupta K, Epperly MW, Franicola D, Zhang X, Wang H, Zhao H, Tyurin VA, Pierce JG, Kagan VE, Wipf P, Kanai AJ, Greenberger JS. The mitochondria-targeted nitroxide JP4-039 augments potentially lethal irradiation damage repair. In Vivo (Athens, Greece). 23: 717-26. PMID 19779106  1
2009 Saiz C, Pizzo C, Manta E, Wipf P, Mahler SG. Microwave assisted tandem reactions for the synthesis of 2-hydrazolyl-4-thiazolidinones. Tetrahedron Letters. 50: 901-904. PMID 19756224 DOI: 10.1016/j.tetlet.2008.12.020  1
2009 Kagan VE, Wipf P, Stoyanovsky D, Greenberger JS, Borisenko G, Belikova NA, Yanamala N, Samhan Arias AK, Tungekar MA, Jiang J, Tyurina YY, Ji J, Klein-Seetharaman J, Pitt BR, Shvedova AA, et al. Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions. Advanced Drug Delivery Reviews. 61: 1375-85. PMID 19716396 DOI: 10.1016/j.addr.2009.06.008  1
2009 Burnett JC, Wang C, Nuss JE, Nguyen TL, Hermone AR, Schmidt JJ, Gussio R, Wipf P, Bavari S. Pharmacophore-guided lead optimization: the rational design of a non-zinc coordinating, sub-micromolar inhibitor of the botulinum neurotoxin serotype a metalloprotease. Bioorganic & Medicinal Chemistry Letters. 19: 5811-3. PMID 19703771 DOI: 10.1016/j.bmcl.2009.01.111  1
2009 Saiz C, Wipf P, Manta E, Mahler G. Reversible thiazolidine exchange: a new reaction suitable for dynamic combinatorial chemistry. Organic Letters. 11: 3170-3. PMID 19585999 DOI: 10.1021/ol901104a  1
2009 Fuller AA, Du D, Liu F, Davoren JE, Bhabha G, Kroon G, Case DA, Dyson HJ, Powers ET, Wipf P, Gruebele M, Kelly JW. Evaluating beta-turn mimics as beta-sheet folding nucleators. Proceedings of the National Academy of Sciences of the United States of America. 106: 11067-72. PMID 19541614 DOI: 10.1073/pnas.0813012106  1
2009 Johnston PA, Foster CA, Tierno MB, Shun TY, Shinde SN, Paquette WD, Brummond KM, Wipf P, Lazo JS. Cdc25B dual-specificity phosphatase inhibitors identified in a high-throughput screen of the NIH compound library. Assay and Drug Development Technologies. 7: 250-65. PMID 19530895 DOI: 10.1089/adt.2008.186  1
2009 Gu L, Wang B, Kulkarni A, Geders TW, Grindberg RV, Gerwick L, HÃ¥kansson K, Wipf P, Smith JL, Gerwick WH, Sherman DH. Metamorphic enzyme assembly in polyketide diversification. Nature. 459: 731-5. PMID 19494914 DOI: 10.1038/nature07870  1
2009 Walczak MA, Shin BK, Wipf P, Saxena S. An ESR analysis of the mechanism of pericyclic reactions of bicyclobutane. Organic & Biomolecular Chemistry. 7: 2363-6. PMID 19462047 DOI: 10.1039/b815469b  1
2009 Hopkins CD, Wipf P. Isolation, biology and chemistry of the disorazoles: new anti-cancer macrodiolides. Natural Product Reports. 26: 585-601. PMID 19387496 DOI: 10.1039/b813799b  1
2009 Mukhopadhyay P, Wipf P, Beratan DN. Optical signatures of molecular dissymmetry: combining theory with experiments to address stereochemical puzzles. Accounts of Chemical Research. 42: 809-19. PMID 19378940 DOI: 10.1021/ar8002859  1
2009 Sarachine MJ, Janjic JM, Wipf P, Day BW. Biphenyl C-cyclopropylalkylamides: New scaffolds for targeting estrogen receptor beta. Bioorganic & Medicinal Chemistry Letters. 19: 2404-8. PMID 19356928 DOI: 10.1016/j.bmcl.2009.03.075  1
2009 Werner S, Nielsen SD, Wipf P, Turner DM, Chambers PG, Geib SJ, Curran DP, Zhang W. Fluorous parallel synthesis of a piperazinedione-fused tricyclic compound library. Journal of Combinatorial Chemistry. 11: 452-9. PMID 19301852 DOI: 10.1021/cc900003q  1
2009 Faraji AH, Wipf P. Nanoparticles in cellular drug delivery. Bioorganic & Medicinal Chemistry. 17: 2950-62. PMID 19299149 DOI: 10.1016/j.bmc.2009.02.043  1
2009 Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA, Borisenko G. Cytochrome c/cardiolipin relations in mitochondria: a kiss of death. Free Radical Biology & Medicine. 46: 1439-53. PMID 19285551 DOI: 10.1016/j.freeradbiomed.2009.03.004  1
2009 Wright CM, Seguin SP, Fewell SW, Zhang H, Ishwad C, Vats A, Lingwood CA, Wipf P, Fanning E, Pipas JM, Brodsky JL. Inhibition of Simian Virus 40 replication by targeting the molecular chaperone function and ATPase activity of T antigen. Virus Research. 141: 71-80. PMID 19200446 DOI: 10.1016/j.virusres.2008.12.018  1
2009 Patham B, Duffy J, Lane A, Davis RC, Wipf P, Fewell SW, Brodsky JL, Mensa-Wilmot K. Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities. The Biochemical Journal. 419: 507-17. PMID 19196237 DOI: 10.1042/BJ20081787  1
2009 Chiang AN, Valderramos JC, Balachandran R, Chovatiya RJ, Mead BP, Schneider C, Bell SL, Klein MG, Huryn DM, Chen XS, Day BW, Fidock DA, Wipf P, Brodsky JL. Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum. Bioorganic & Medicinal Chemistry. 17: 1527-33. PMID 19195901 DOI: 10.1016/j.bmc.2009.01.024  1
2009 Ihle NT, Lemos R, Schwartz D, Oh J, Halter RJ, Wipf P, Kirkpatrick L, Powis G. Peroxisome proliferator-activated receptor gamma agonist pioglitazone prevents the hyperglycemia caused by phosphatidylinositol 3-kinase pathway inhibition by PX-866 without affecting antitumor activity. Molecular Cancer Therapeutics. 8: 94-100. PMID 19139117 DOI: 10.1158/1535-7163.MCT-08-0714  1
2009 Ihle NT, Lemos R, Wipf P, Yacoub A, Mitchell C, Siwak D, Mills GB, Dent P, Kirkpatrick DL, Powis G. Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Research. 69: 143-50. PMID 19117997 DOI: 10.1158/0008-5472.CAN-07-6656  1
2009 Petronijevic F, Timmons C, Cuzzupe A, Wipf P. A microwave assisted intramolecular-furan-Diels-Alder approach to 4-substituted indoles. Chemical Communications (Cambridge, England). 104-6. PMID 19082013 DOI: 10.1039/b816989f  1
2009 Banerjee A, Sergienko E, Vasile S, Gupta V, Vuori K, Wipf P. Triple hybrids of steroids, spiroketals, and oligopeptides as new biomolecular chimeras. Organic Letters. 11: 65-8. PMID 19067551 DOI: 10.1021/ol802247m  1
2009 Tierno MB, Kitchens CA, Petrik B, Graham TH, Wipf P, Xu FL, Saunders WS, Raccor BS, Balachandran R, Day BW, Stout JR, Walczak CE, Ducruet AP, Reese CE, Lazo JS. Microtubule binding and disruption and induction of premature senescence by disorazole C(1). The Journal of Pharmacology and Experimental Therapeutics. 328: 715-22. PMID 19066338 DOI: 10.1124/jpet.108.147330  1
2009 Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA. Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: a new strategy in anti-apoptotic drug discovery. Molecular Nutrition & Food Research. 53: 104-14. PMID 18979502 DOI: 10.1002/mnfr.200700402  1
2009 Wang C, Widom J, Petronijevic F, Burnett JC, Nuss JE, Bavari S, Gussio R, Wipf P. Synthesis and biological evaluation of inhibitors of botulinum neurotoxin metalloprotease Heterocycles. 79: 487-520. DOI: 10.3987/COM-08-S(D)8  1
2009 Scarone L, Fajardo J, Saldaña J, Domínguez L, Espósito P, Demastteis S, Wipf P, Manta E, Serra G. Synthesis and evaluation of anthelmintic and cytotoxic properties of [2,5']bis-1,3-azole analogs of bengazoles Letters in Drug Design and Discovery. 6: 413-419. DOI: 10.2174/157018009789057553  1
2009 Brimble M, St Clair Black D, Ciufolini MA, Fukuyama T, Fürstner A, Grigg R, Hiemstra H, MacMillan DWC, Shibasaki M, Tietze L, Wipf P. Editorial Advisory Board Members Progress in Heterocyclic Chemistry 2008-2009 Progress in Heterocyclic Chemistry. 21: xii. DOI: 10.1016/S0959-6380(09)70027-3  1
2009 Fürstner A, Alcarazo M, Krause H, Wipf P, Deutsch C. Tetrakis(dimethylamino)allene Organic Syntheses. 86: 298-307.  1
2009 Du H, Zhao B, Shi Y, Buck EE, Wipf P. Pd(0)-catalyzed diamination of trans-1-phenyl-1,3-butadiene with di-tert-butyldiaziridinone as nitrogen source Organic Syntheses. 86: 315-324.  1
2008 Ueda M, Walczak MA, Wipf P. Formal Alder-ene reaction of a bicyclo[1.1.0]butane in the synthesis of the tricyclic quaternary ammonium core of daphniglaucins. Tetrahedron Letters. 49: 5986-5989. PMID 19129907 DOI: 10.1016/j.tetlet.2008.07.179  1
2008 Lazo JS, Wipf P. Is Cdc25 a druggable target? Anti-Cancer Agents in Medicinal Chemistry. 8: 837-842. PMID 19075566 DOI: 10.2174/187152008786847738  1
2008 Hermone AR, Burnett JC, Nuss JE, Tressler LE, Nguyen TL, Solaja BA, Vennerstrom JL, Schmidt JJ, Wipf P, Bavari S, Gussio R. Three-dimensional database mining identifies a unique chemotype that unites structurally diverse botulinum neurotoxin serotype A inhibitors in a three-zone pharmacophore. Chemmedchem. 3: 1905-12. PMID 19006141 DOI: 10.1002/cmdc.200800241  1
2008 Timmons C, Wipf P. Density functional theory calculation of 13C NMR shifts of diazaphenanthrene alkaloids: Reinvestigation of the structure of samoquasine A Journal of Organic Chemistry. 73: 9168-9170. PMID 18925785 DOI: 10.1021/jo801735e  1
2008 Bakan A, Lazo JS, Wipf P, Brummond KM, Bahar I. Toward a molecular understanding of the interaction of dual specificity phosphatases with substrates: insights from structure-based modeling and high throughput screening. Current Medicinal Chemistry. 15: 2536-44. PMID 18855677 DOI: 10.2174/092986708785909003  1
2008 Sharlow ER, Giridhar KV, LaValle CR, Chen J, Leimgruber S, Barrett R, Bravo-Altamirano K, Wipf P, Lazo JS, Wang QJ. Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. The Journal of Biological Chemistry. 283: 33516-26. PMID 18829454 DOI: 10.1074/jbc.M805358200  1
2008 Keinan S, Paquette WD, Skoko JJ, Beratan DN, Yang W, Shinde S, Johnston PA, Lazo JS, Wipf P. Computational design, synthesis and biological evaluation of para-quinone-based inhibitors for redox regulation of the dual-specificity phosphatase Cdc25B. Organic & Biomolecular Chemistry. 6: 3256-63. PMID 18802630 DOI: 10.1039/b806712k  1
2008 Wipf P, Maciejewski JP. Titanocene(III)-catalyzed formation of indolines and azaindolines. Organic Letters. 10: 4383-6. PMID 18781767 DOI: 10.1021/ol801860s  1
2008 Pierce JG, Kasi D, Fushimi M, Cuzzupe A, Wipf P. Synthesis of hydroxylated bicyclic amino acids from L-tyrosine: octahydro-1H-indole carboxylates. The Journal of Organic Chemistry. 73: 7807-10. PMID 18767800 DOI: 10.1021/jo801552j  1
2008 Johnston PA, Soares KM, Shinde SN, Foster CA, Shun TY, Takyi HK, Wipf P, Lazo JS. Development of a 384-well colorimetric assay to quantify hydrogen peroxide generated by the redox cycling of compounds in the presence of reducing agents. Assay and Drug Development Technologies. 6: 505-18. PMID 18699726 DOI: 10.1089/adt.2008.151  1
2008 Rabu C, Wipf P, Brodsky JL, High S. A precursor-specific role for Hsp40/Hsc70 during tail-anchored protein integration at the endoplasmic reticulum. The Journal of Biological Chemistry. 283: 27504-13. PMID 18667436 DOI: 10.1074/jbc.M804591200  1
2008 Walczak MA, Wipf P. Rhodium(I)-catalyzed cycloisomerizations of bicyclobutanes. Journal of the American Chemical Society. 130: 6924-5. PMID 18461936 DOI: 10.1021/ja802906k  1
2008 Liu F, Du D, Fuller AA, Davoren JE, Wipf P, Kelly JW, Gruebele M. An experimental survey of the transition between two-state and downhill protein folding scenarios. Proceedings of the National Academy of Sciences of the United States of America. 105: 2369-74. PMID 18268349 DOI: 10.1073/pnas.0711908105  1
2008 Jiang J, Belikova NA, Hoye AT, Zhao Q, Epperly MW, Greenberger JS, Wipf P, Kagan VE. A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation. International Journal of Radiation Oncology, Biology, Physics. 70: 816-25. PMID 18262096 DOI: 10.1016/j.ijrobp.2007.10.047  1
2008 Vogt A, McDonald PR, Tamewitz A, Sikorski RP, Wipf P, Skoko JJ, Lazo JS. A cell-active inhibitor of mitogen-activated protein kinase phosphatases restores paclitaxel-induced apoptosis in dexamethasone-protected cancer cells. Molecular Cancer Therapeutics. 7: 330-40. PMID 18245669 DOI: 10.1158/1535-7163.MCT-07-2165  1
2008 Zuber G, Wipf P, Beratan DN. Exploring the optical activity tensor by anisotropic Rayleigh optical activity scattering. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 9: 265-71. PMID 18219646 DOI: 10.1002/cphc.200700660  1
2008 Balachandran R, Hopkins TD, Thomas CA, Wipf P, Day BW. Tubulin-perturbing naphthoquinone spiroketals. Chemical Biology & Drug Design. 71: 117-24. PMID 18194192 DOI: 10.1111/j.1747-0285.2007.00616.x  1
2008 Hoye AT, Davoren JE, Wipf P, Fink MP, Kagan VE. Targeting mitochondria. Accounts of Chemical Research. 41: 87-97. PMID 18193822 DOI: 10.1021/ar700135m  1
2008 Wright CM, Chovatiya RJ, Jameson NE, Turner DM, Zhu G, Werner S, Huryn DM, Pipas JM, Day BW, Wipf P, Brodsky JL. Pyrimidinone-peptoid hybrid molecules with distinct effects on molecular chaperone function and cell proliferation. Bioorganic & Medicinal Chemistry. 16: 3291-301. PMID 18164205 DOI: 10.1016/j.bmc.2007.12.014  1
2008 Wipf P. Sixteen semesters of chemistry at the University of Zürich: A retrospective on a formative time Chimia. 62: 150-151. DOI: 10.2533/chimia.2008.150  1
2008 Huryn DM, Wipf P. Natural product chemistry and anticancer drug discovery Cancer Drug Design and Discovery. 107-130. DOI: 10.1016/B978-012369448-5.50008-2  1
2008 Wipf P, Jayasuriya N. Chiral ligand optimization in the asymmetric zirconium-zinc transmetalation aldehyde addition reaction Chirality. 20: 425-430. DOI: 10.1002/chir.20468  1
2007 Pierce JG, Waller DL, Wipf P. Synthesis of Functionalized Isoindolinones: Addition of In Situ Generated Organoalanes to Acyliminium Ions. Journal of Organometallic Chemistry. 692: 4618-4629. PMID 19684878 DOI: 10.1016/j.jorganchem.2007.05.035  1
2007 Guo J, Parise RA, Joseph E, Lan J, Pan SS, Joo B, Egorin MJ, Wipf P, Lazo JS, Eiseman JL. Pharmacology and antitumor activity of a quinolinedione Cdc25 phosphatase inhibitor DA3003-1 (NSC 663284). Anticancer Research. 27: 3067-73. PMID 17970046  1
2007 Fink MP, Macias CA, Xiao J, Tyurina YY, Delude RL, Greenberger JS, Kagan VE, Wipf P. Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants. Critical Care Medicine. 35: S461-7. PMID 17713394 DOI: 10.1097/01.CCM.0000279192.96303.E7  1
2007 Wang Z, McPherson PA, Raccor BS, Balachandran R, Zhu G, Day BW, Vogt A, Wipf P. Structure-activity and high-content imaging analyses of novel tubulysins. Chemical Biology & Drug Design. 70: 75-86. PMID 17683369 DOI: 10.1111/j.1747-0285.2007.00541.x  1
2007 Mukhopadhyay P, Zuber G, Wipf P, Beratan DN. Contribution of a solute's chiral solvent imprint to optical rotation. Angewandte Chemie (International Ed. in English). 46: 6450-2. PMID 17645276 DOI: 10.1002/anie.200702273  1
2007 Johnston PA, Foster CA, Shun TY, Skoko JJ, Shinde S, Wipf P, Lazo JS. Development and implementation of a 384-well homogeneous fluorescence intensity high-throughput screening assay to identify mitogen-activated protein kinase phosphatase-1 dual-specificity protein phosphatase inhibitors. Assay and Drug Development Technologies. 5: 319-32. PMID 17638532 DOI: 10.1089/adt.2007.066  1
2007 Wakefield B, Halter RJ, Wipf P. Synthesis of (+/-)-thiohalenaquinone by iterative metalations of thiophene. Organic Letters. 9: 3121-4. PMID 17630756 DOI: 10.1021/ol071258y  1
2007 Rodina A, Vilenchik M, Moulick K, Aguirre J, Kim J, Chiang A, Litz J, Clement CC, Kang Y, She Y, Wu N, Felts S, Wipf P, Massague J, Jiang X, et al. Selective compounds define Hsp90 as a major inhibitor of apoptosis in small-cell lung cancer. Nature Chemical Biology. 3: 498-507. PMID 17603540 DOI: 10.1038/nchembio.2007.10  1
2007 Fink MP, Macias CA, Xiao J, Tyurina YY, Jiang J, Belikova N, Delude RL, Greenberger JS, Kagan VE, Wipf P. Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted anti-oxidants. Biochemical Pharmacology. 74: 801-9. PMID 17601494 DOI: 10.1016/j.bcp.2007.05.019  1
2007 Wipf P, Gong H, Janjic JM, Li S, Day BW, Xie W. New opportunities for pregnane X receptor (PXR) targeting in drug development. lessons from Enantio- and species-specific PXR ligands identified from a discovery library of amino acid analogues. Mini Reviews in Medicinal Chemistry. 7: 617-25. PMID 17584160 DOI: 10.2174/138955707780859404  1
2007 Lee MR, Raguse TL, Schinnerl M, Pomerantz WC, Wang X, Wipf P, Gellman SH. Origins of the high 14-helix propensity of cyclohexyl-rigidified residues in beta-peptides. Organic Letters. 9: 1801-4. PMID 17394351 DOI: 10.1021/ol070511r  1
2007 Arnold DM, Foster C, Huryn DM, Lazo JS, Johnston PA, Wipf P. Synthesis and biological activity of a focused library of mitogen-activated protein kinase phosphatase inhibitors. Chemical Biology & Drug Design. 69: 23-30. PMID 17313454 DOI: 10.1111/j.1747-0285.2007.00474.x  1
2007 Macias CA, Chiao JW, Xiao J, Arora DS, Tyurina YY, Delude RL, Wipf P, Kagan VE, Fink MP. Treatment with a novel hemigramicidin-TEMPO conjugate prolongs survival in a rat model of lethal hemorrhagic shock. Annals of Surgery. 245: 305-14. PMID 17245186 DOI: 10.1097/01.sla.0000236626.57752.8e  1
2007 Jiang J, Kurnikov I, Belikova NA, Xiao J, Zhao Q, Amoscato AA, Braslau R, Studer A, Fink MP, Greenberger JS, Wipf P, Kagan VE. Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides Journal of Pharmacology and Experimental Therapeutics. 320: 1050-1060. PMID 17179468 DOI: 10.1124/jpet.106.114769  1
2007 Waller DL, Stephenson CR, Wipf P. Spiroketals via oxidative rearrangement of enol ethers. Organic & Biomolecular Chemistry. 5: 58-60. PMID 17164906 DOI: 10.1039/B612992G  1
2007 Burnett JC, Ruthel G, Stegmann CM, Panchal RG, Nguyen TL, Hermone AR, Stafford RG, Lane DJ, Kenny TA, McGrath CF, Wipf P, Stahl AM, Schmidt JJ, Gussio R, Brunger AT, et al. Inhibition of metalloprotease botulinum serotype A from a pseudo-peptide binding mode to a small molecule that is active in primary neurons. The Journal of Biological Chemistry. 282: 5004-14. PMID 17092934 DOI: 10.1074/jbc.M608166200  1
2007 Brisson M, Foster C, Wipf P, Joo B, Tomko RJ, Nguyen T, Lazo JS. Independent mechanistic inhibition of cdc25 phosphatases by a natural product caulibugulone. Molecular Pharmacology. 71: 184-92. PMID 17018577 DOI: 10.1124/mol.106.028589  1
2006 Mukhopadhyay P, Zuber G, Goldsmith MR, Wipf P, Beratan DN. Solvent effect on optical rotation: A case study of methyloxirane in water. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 7: 2483-6. PMID 17072929 DOI: 10.1002/cphc.200600477  1
2006 Xiao J, Weisblum B, Wipf P. Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold. Organic Letters. 8: 4731-4. PMID 17020289 DOI: 10.1021/ol0617704  1
2006 Wipf P, Pierce JG. Expedient synthesis of the alpha-C-glycoside analogue of the immunostimulant galactosylceramide (KRN7000). Organic Letters. 8: 3375-8. PMID 16836409 DOI: 10.1021/ol0613057  1
2006 Cossy J, Belotti D, Brisson M, Skoko JJ, Wipf P, Lazo JS. Biological evaluation of newly synthesized quinoline-5,8-quinones as Cdc25B inhibitors Bioorganic and Medicinal Chemistry. 14: 6283-6287. PMID 16782352 DOI: 10.1016/j.bmc.2006.05.053  1
2006 Wipf P, Walczak MA. Pericyclic cascade reactions of (bicyclo[1.1.0]butylmethyl)amines. Angewandte Chemie (International Ed. in English). 45: 4172-5. PMID 16710876 DOI: 10.1002/anie.200600723  1
2006 Wipf P, Wang C. Synthesis and Ag(I) complexation studies of tethered westiellamide. Organic Letters. 8: 2381-4. PMID 16706531 DOI: 10.1021/ol060677c  1
2006 Levinson N, Hinman R, Patil A, Stephenson CR, Werner S, Woo GH, Xiao J, Wipf P, Lynch KW. Use of transcriptional synergy to augment sensitivity of a splicing reporter assay. Rna (New York, N.Y.). 12: 925-30. PMID 16556940 DOI: 10.1261/rna.8306  1
2006 Powis G, Wipf P, Lynch SM, Birmingham A, Kirkpatrick DL. Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase. Molecular Cancer Therapeutics. 5: 630-6. PMID 16546977 DOI: 10.1158/1535-7163.MCT-05-0487  1
2006 Wipf P, Graham TH, Vogt A, Sikorski RP, Ducruet AP, Lazo JS. Cellular analysis of disorazole C and structure-activity relationship of analogs of the natural product. Chemical Biology & Drug Design. 67: 66-73. PMID 16492150 DOI: 10.1111/j.1747-0285.2005.00313.x  0.92
2006 Goldsmith MR, George CB, Zuber G, Naaman R, Waldeck DH, Wipf P, Beratan DN. The chiroptical signature of achiral metal clusters induced by dissymmetric adsorbates. Physical Chemistry Chemical Physics : Pccp. 8: 63-7. PMID 16482245 DOI: 10.1039/b511563a  1
2006 Chen Z, Yang Y, Werner S, Wipf P, Weber SG. A screening method for chiral selectors that does not require covalent attachment. Journal of the American Chemical Society. 128: 2208-9. PMID 16478163 DOI: 10.1021/ja058004x  1
2006 Sellanes D, Scarone L, Mahler G, Manta E, Baz A, Dematteis S, Saldaña J, Domínguez L, Wipf P, Serra G. Synthesis and evaluation of anthelmintic and cytotoxic properties of bis-1,3-azole analogs of natural products Letters in Drug Design and Discovery. 3: 35-43. DOI: 10.2174/157018006775240962  1
2006 Wipf P, Grenon M. Toward the total synthesis of lophotoxin - New methodologies and synthetic strategies Canadian Journal of Chemistry. 84: 1226-1241. DOI: 10.1139/V06-073  1
2006 Werner S, Turner DM, Lyon MA, Huryn DM, Wipf P. A focused library of tetrahydropyrimidinone amides via a tandem Biginelli-Ugi multi-component process Synlett. 2334-2338. DOI: 10.1055/s-2006-949648  1
2005 Wipf P, Waller DL, Reeves JT. Transition-metal-mediated cascade reactions: the water-accelerated carboalumination-Claisen rearrangement-carbonyl addition reaction. The Journal of Organic Chemistry. 70: 8096-102. PMID 16277333 DOI: 10.1021/jo051211v  1
2005 Zuber G, Goldsmith MR, Hopkins TD, Beratan DN, Wipf P. Systematic assignment of the configuration of flexible natural products by spectroscopic and computational methods: the bistramide C analysis. Organic Letters. 7: 5269-72. PMID 16268555 DOI: 10.1021/ol052154v  1
2005 Wipf P, Lynch SM, Powis G, Birmingham A, Englund EE. Synthesis and biological activity of prodrug inhibitors of the thioredoxin-thioredoxin reductase system. Organic & Biomolecular Chemistry. 3: 3880-2. PMID 16240002 DOI: 10.1039/b510718k  1
2005 Moss RA, Fu X, Sauers RR, Wipf P. Endo entry to the nortricyclyl-norbornenyl cation system: stereochemistry in the fragmentation of endo-5-norbornenyl-2-oxychlorocarbene. The Journal of Organic Chemistry. 70: 8454-60. PMID 16209591 DOI: 10.1021/jo051222o  1
2005 Nguyen TL, McGrath C, Hermone AR, Burnett JC, Zaharevitz DW, Day BW, Wipf P, Hamel E, Gussio R. A common pharmacophore for a diverse set of colchicine site inhibitors using a structure-based approach. Journal of Medicinal Chemistry. 48: 6107-16. PMID 16162011 DOI: 10.1021/jm050502t  1
2005 Brisson M, Nguyen T, Wipf P, Joo B, Day BW, Skoko JS, Schreiber EM, Foster C, Bansal P, Lazo JS. Redox regulation of Cdc25B by cell-active quinolinediones. Molecular Pharmacology. 68: 1810-20. PMID 16155209 DOI: 10.1124/mol.105.016360  1
2005 Zuber G, Goldsmith MR, Beratan DN, Wipf P. Assignment of the absolute configuration of [n]-ladderanes by TD-DFT optical rotation calculations. Chirality. 17: 507-10. PMID 16121333 DOI: 10.1002/chir.20190  1
2005 Wipf P, Pierce JG. Synthesis of homoallylic amines by hydrozirconation-imine addition of allenes. Organic Letters. 7: 3537-40. PMID 16048336 DOI: 10.1002/chin.200549077  1
2005 Wipf P, Halter RJ. Chemistry and biology of wortmannin. Organic & Biomolecular Chemistry. 3: 2053-61. PMID 15917886 DOI: 10.1039/b504418a  1
2005 Zuber G, Goldsmith MR, Beratan DN, Wipf P. Towards Raman optical activity calculations of large molecules. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 6: 595-7. PMID 15881572 DOI: 10.1002/cphc.200400544  1
2005 Mu Y, Stephenson CR, Kendall C, Saini SP, Toma D, Ren S, Cai H, Strom SC, Day BW, Wipf P, Xie W. A pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development. Molecular Pharmacology. 68: 403-13. PMID 15872116 DOI: 10.1124/mol.105.013292  1
2005 Xiao J, Weisblum B, Wipf P. Electrostatic versus steric effects in peptidomimicry: synthesis and secondary structure analysis of gramicidin S analogues with (E)-alkene peptide isosteres. Journal of the American Chemical Society. 127: 5742-3. PMID 15839644 DOI: 10.1021/ja051002s  1
2005 Moss RA, Fu X, Tian J, Sauers R, Wipf P. Stereochemistry of oxachlorocarbene S(N)i reactions. Organic Letters. 7: 1371-4. PMID 15787509 DOI: 10.1021/ol050185k  1
2005 Wipf P, Coleman CM, Janjic JM, Iyer PS, Fodor MD, Shafer YA, Stephenson CR, Kendall C, Day BW. Microwave-assisted "libraries from libraries" approach toward the synthesis of allyl- and C-cyclopropylalkylamides. Journal of Combinatorial Chemistry. 7: 322-30. PMID 15762763 DOI: 10.1002/chin.200532163  1
2005 Wipf P, Stephenson CR. Three-component synthesis of alpha,beta-cyclopropyl-gamma-amino acids. Organic Letters. 7: 1137-40. PMID 15760158 DOI: 10.1021/ol0501525  1
2005 Wipf P, Pierce JG, Zhuang N. Silver(I)-catalyzed addition of zirconocenes to glycal epoxides. A new synthesis of alpha-C-glycosides. Organic Letters. 7: 483-5. PMID 15673270 DOI: 10.1002/chin.200525189  1
2005 Wipf P, Spencer SR. Asymmetric total syntheses of tuberostemonine, didehydrotuberostemonine, and 13-epituberostemonine. Journal of the American Chemical Society. 127: 225-35. PMID 15631472 DOI: 10.1021/ja044280k  1
2005 Wipf P, Graham TH. Synthesis and hetero-Michael addition reactions of 2-alkynyl oxazoles and oxazolines. Organic & Biomolecular Chemistry. 3: 31-5. PMID 15602595 DOI: 10.1002/chin.200521132  0.92
2005 Janjic JM, Mu Y, Kendall C, Stephenson CR, Balachandran R, Raccor BS, Lu Y, Zhu G, Xie W, Wipf P, Day BW. New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. Bioorganic & Medicinal Chemistry. 13: 157-64. PMID 15582460 DOI: 10.1016/j.bmc.2004.09.048  1
2005 Fu X, Moss RA, Sauers RR, Wipf P. The fragmentation of exo-5-norbornenyl-2-oxychlorocarbene: Stereochemistry and mechanism Tetrahedron Letters. 46: 4265-4268. DOI: 10.1016/j.tetlet.2005.03.208  1
2005 Wipf P, Werner S, Woo GHC, Stephenson CRJ, Walczak MAA, Coleman CM, Twining LA. Application of divergent multi-component reactions in the synthesis of a library of peptidomimetics based on γ-amino-α,β-cyclopropyl acids Tetrahedron. 61: 11488-11500. DOI: 10.1016/j.tet.2005.09.016  1
2004 Wipf P, Graham TH. Total synthesis of (-)-disorazole C1. Journal of the American Chemical Society. 126: 15346-7. PMID 15563138 DOI: 10.1021/ja0443068  0.92
2004 Wipf P, Takada T, Rishel MJ. Synthesis of the tubuvaline-tubuphenylalanine (Tuv-Tup) fragment of tubulysin. Organic Letters. 6: 4057-60. PMID 15496098 DOI: 10.1021/ol048252i  1
2004 Fewell SW, Smith CM, Lyon MA, Dumitrescu TP, Wipf P, Day BW, Brodsky JL. Small molecule modulators of endogenous and co-chaperone-stimulated Hsp70 ATPase activity. The Journal of Biological Chemistry. 279: 51131-40. PMID 15448148 DOI: 10.1074/jbc.M404857200  1
2004 Wipf P, Aoyama Y, Benedum TE. A practical method for oxazole synthesis by cycloisomerization of propargyl amides. Organic Letters. 6: 3593-5. PMID 15387556 DOI: 10.1021/ol0485058  1
2004 Wipf P, Stephenson CR, Walczak MA. Diversity-oriented synthesis of azaspirocycles. Organic Letters. 6: 3009-12. PMID 15330670 DOI: 10.1002/chin.200450136  1
2004 Wipf P, Joo B, Nguyen T, Lazo JS. Synthesis and biological evaluation of caulibugulones A-E. Organic & Biomolecular Chemistry. 2: 2173-4. PMID 15280951 DOI: 10.1002/chin.200452197  1
2004 Brisson M, Nguyen T, Vogt A, Yalowich J, Giorgianni A, Tobi D, Bahar I, Stephenson CR, Wipf P, Lazo JS. Discovery and characterization of novel small molecule inhibitors of human Cdc25B dual specificity phosphatase. Molecular Pharmacology. 66: 824-33. PMID 15231869 DOI: 10.1124/mol.104.001784  1
2004 Wipf P, Minion DJ, Halter RJ, Berggren MI, Ho CB, Chiang GG, Kirkpatrick L, Abraham R, Powis G. Synthesis and biological evaluation of synthetic viridins derived from C(20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin. Organic & Biomolecular Chemistry. 2: 1911-20. PMID 15227545 DOI: 10.1039/b405431h  1
2004 Wipf P, Lynch SM, Birmingham A, Tamayo G, Jiménez A, Campos N, Powis G. Natural product based inhibitors of the thioredoxin-thioredoxin reductase system. Organic & Biomolecular Chemistry. 2: 1651-8. PMID 15162219 DOI: 10.1039/b402431a  1
2004 Wipf P, Reeves JT, Day BW. Chemistry and biology of curacin A. Current Pharmaceutical Design. 10: 1417-37. PMID 15134491 DOI: 10.2174/1381612043384853  1
2004 Wipf P, Janjic J, Stephenson CR. Microwave-assisted synthesis of allylic amines: considerable rate acceleration in the hydrozirconation-transmetalation-aldimine addition sequence. Organic & Biomolecular Chemistry. 2: 443-5. PMID 14770219 DOI: 10.1039/b316741k  1
2004 Han Y, Shen H, Carr BI, Wipf P, Lazo JS, Pan SS. NAD(P)H:quinone oxidoreductase-1-dependent and -independent cytotoxicity of potent quinone Cdc25 phosphatase inhibitors. The Journal of Pharmacology and Experimental Therapeutics. 309: 64-70. PMID 14718602 DOI: 10.1124/jpet.103.059477  0.56
2003 Goldsmith MR, Jayasuriya N, Beratan DN, Wipf P. Optical rotation of noncovalent aggregates. Journal of the American Chemical Society. 125: 15696-7. PMID 14677931 DOI: 10.1021/ja0376893  1
2003 Wipf P, Stephenson CR, Okumura K. Transition-metal-mediated cascade reactions: C,C-dicyclopropylmethylamines by way of double C,C-sigma-bond insertion into bicyclobutanes. Journal of the American Chemical Society. 125: 14694-5. PMID 14640630 DOI: 10.1002/CHIN.200413056  1
2003 Wipf P, Graham TH. Photoactivated tungsten hexacarbonyl-catalyzed conversion of alkynols to glycals. The Journal of Organic Chemistry. 68: 8798-807. PMID 14604347 DOI: 10.1021/jo034813s  0.92
2003 Vogt A, Cooley KA, Brisson M, Tarpley MG, Wipf P, Lazo JS. Cell-active dual specificity phosphatase inhibitors identified by high-content screening. Chemistry & Biology. 10: 733-42. PMID 12954332 DOI: 10.1016/S1074-5521(03)00170-4  1
2003 Wipf P, Stephenson CR. Dimethylzinc-mediated addition of alkenylzirconocenes to alpha-keto and alpha-imino esters. Organic Letters. 5: 2449-52. PMID 12841752 DOI: 10.1021/ol0347141  1
2003 Wipf P, Lynch SM. Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base. Organic Letters. 5: 1155-8. PMID 12659597 DOI: 10.1021/ol034286z  1
2003 Wipf P, Kendall C, Stephenson CR. Dimethylzinc-mediated additions of alkenylzirconocenes to aldimines. New methodologies for allylic amine and C-cyclopropylalkylamine syntheses. Journal of the American Chemical Society. 125: 761-8. PMID 12526676 DOI: 10.1021/ja028092a  1
2003 Wipf P, Wang X. Parallel synthesis of oxazolines and thiazolines by tandem condensation-cyclodehydration of carboxylic acids with amino alcohols and aminothiols. Journal of Combinatorial Chemistry. 4: 656-60. PMID 12425611 DOI: 10.1021/cc020041m  0.36
2003 Wipf P, Pierce JG, Wang X. Investigation of ligand loading and asymmetric amplification in CHAOx-catalyzed asymmetric diethylzinc additions Tetrahedron Asymmetry. 14: 3605-3611. DOI: 10.1016/j.tetasy.2003.07.022  1
2002 Wipf P, Rector SR, Takahashi H. Total synthesis of (-)-tuberostemonine. Journal of the American Chemical Society. 124: 14848-9. PMID 12475317 DOI: 10.1002/chin.200316210  1
2002 El Sayed KA, Yousaf M, Hamann MT, Avery MA, Kelly M, Wipf P. Microbial and chemical transformation studies of the bioactive marine sesquiterpenes (S)-(+)-curcuphenol and -curcudiol isolated from a deep reef collection of the Jamaican sponge Didiscus oxeata. Journal of Natural Products. 65: 1547-53. PMID 12444675 DOI: 10.1021/np020213x  1
2002 Wipf P, Reeves JT. A formal total synthesis of leucascandrolide A. Chemical Communications (Cambridge, England). 2066-7. PMID 12357781 DOI: 10.1039/B207383H  1
2002 Wipf P, Reeves JT, Balachandran R, Day BW. Synthesis and biological evaluation of structurally highly modified analogues of the antimitotic natural product curacin A. Journal of Medicinal Chemistry. 45: 1901-17. PMID 11960501 DOI: 10.1021/jm0105171  1
2002 Wipf P, Uto Y, Yoshimura S. Total synthesis of a stereoisomer of bistramide C and assignment of configuration of the natural product. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 1670-81. PMID 11933095 DOI: 10.1002/1521-3765(20020402)8:7<1670::AID-CHEM1670>3.0.CO;2-4  1
2002 Lazo JS, Nemoto K, Pestell KE, Cooley K, Southwick EC, Mitchell DA, Furey W, Gussio R, Zaharevitz DW, Joo B, Wipf P. Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors. Molecular Pharmacology. 61: 720-8. PMID 11901209 DOI: 10.1124/mol.61.4.720  1
2002 Wipf P, Hopkins CR, Phillips EO, Lazo JS. Separation of Cdc25 dual specificity phosphatase inhibition and DNA cleaving activities in a focused library of analogs of the antitumor antibiotic Dnacin Tetrahedron. 58: 6367-6372. DOI: 10.1016/S0040-4020(02)00636-1  1
2002 Beratan DN, Kondru RK, Wipf P. Optical activity: From structure - Function to structure prediction Acs Symposium Series. 810: 104-118.  1
2001 Lazo JS, Aslan DC, Southwick EC, Cooley KA, Ducruet AP, Joo B, Vogt A, Wipf P. Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. Journal of Medicinal Chemistry. 44: 4042-9. PMID 11708908 DOI: 10.1021/jm0102046  1
2001 Wipf P, Reeves JT. Glycosylation via Cp2ZrCl2/AgClO4-mediated activation of anomeric sulfoxides. The Journal of Organic Chemistry. 66: 7910-4. PMID 11701059 DOI: 10.1021/jo015952h  1
2001 Specht KM, Nam J, Ho DM, Berova N, Kondru RK, Beratan DN, Wipf P, Pascal RA, Kahne D. Determining absolute configuration in flexible molecules: a case study. Journal of the American Chemical Society. 123: 8961-6. PMID 11552802 DOI: 10.1021/ja0104406  0.4
2001 Wipf P, Hopkins TD, Jung JK, Rodriguez S, Birmingham A, Southwick EC, Lazo JS, Powis G. New inhibitors of the thioredoxin-thioredoxin reductase system based on a naphthoquinone spiroketal natural product lead. Bioorganic & Medicinal Chemistry Letters. 11: 2637-41. PMID 11551767 DOI: 10.1016/S0960-894X(01)00525-X  0.56
2001 Wipf P, Kendall C, Stephenson CR. Three-component aldimine addition--cyclopropanation. an efficient new methodology for amino cyclopropane synthesis. Journal of the American Chemical Society. 123: 5122-3. PMID 11457353 DOI: 10.1021/ja0157494  1
2001 Wipf P, Methot JL. Synthetic studies toward diazonamide A. A novel approach for polyoxazole synthesis. Organic Letters. 3: 1261-4. PMID 11348209 DOI: 10.1021/ol0157196  1
2001 Wipf P, Graham TH. Synthesis of the C(1')--C(11') segment of leucascandrolide A. The Journal of Organic Chemistry. 66: 3242-5. PMID 11325299 DOI: 10.1021/jo005787q  0.44
2001 Wipf P, Hopkins CR. Enantioselective synthesis of the AB-ring system of the antitumor antibiotic tetrazomine. The Journal of Organic Chemistry. 66: 3133-9. PMID 11325279 DOI: 10.1021/jo015512q  1
2001 Perry TL, Dickerson A, Khan AA, Kondru RK, Beratan DN, Wipf P, Kelly M, Hamann MT. New peroxylactones from the Jamaican sponge Plakinastrella onkodes, with inhibitory activity against the AIDS opportunistic parasitic infection Toxoplasma gondii Tetrahedron. 57: 1483-1487. DOI: 10.1016/S0040-4020(00)01134-0  1
2000 Wipf P, Methot JL. Total synthesis and stereochemical revision of (+)-aeruginosin 298-A. Organic Letters. 2: 4213-6. PMID 11150202 DOI: 10.1021/ol006759x  1
2000 Ducruet AP, Rice RL, Tamura K, Yokokawa F, Yokokawa S, Wipf P, Lazo JS. Identification of new Cdc25 dual specificity phosphatase inhibitors in a targeted small molecule array. Bioorganic & Medicinal Chemistry. 8: 1451-66. PMID 10896122 DOI: 10.1016/S0968-0896(00)00069-9  1
2000 Kondru RK, Beratan DN, Friestad GK, Smith AB, Wipf P. Chiral action at a distance: remote substituent effects on the optical activity of calyculins A and B. Organic Letters. 2: 1509-12. PMID 10841466 DOI: 10.1021/ol005634p  1
2000 Wipf P, Uto Y. Total synthesis and revision of stereochemistry of the marine metabolite trunkamide A. The Journal of Organic Chemistry. 65: 1037-49. PMID 10814052 DOI: 10.1021/jo9914566  1
2000 Phillips AJ, Uto Y, Wipf P, Reno MJ, Williams DR. Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor. Organic Letters. 2: 1165-8. PMID 10804580 DOI: 10.1021/ol005777b  1
2000 Ribe S, Kondru RK, Beratan DN, Wipf P. Optical rotation computation, total synthesis, and stereochemistry assignment of the marine natural product pitiamide A Journal of the American Chemical Society. 122: 4608-4617. DOI: 10.1021/ja9945313  1
2000 Wipf P, Reeves JT, Balachandran R, Giuliano KA, Hamel E, Day BW. Synthesis and biological evaluation of a focused mixture library of analogues of the antimitotic marine natural product curacin A Journal of the American Chemical Society. 122: 9391-9395. DOI: 10.1021/ja002213u  1
2000 Wipf P, Miller CP, Grant CM. Synthesis of cyclopeptide alkaloids by cyclooligomerization of dipeptidyl oxazolines Tetrahedron. 56: 9143-9150. DOI: 10.1016/S0040-4020(00)00767-5  1
1999 Wipf P, Hopkins CR. Efficient Synthesis of 1,4-Dihydro-2H-isoquinoline-3,5,8-triones via Cyclobutene Ring Expansion. The Journal of Organic Chemistry. 64: 6881-6887. PMID 11674700 DOI: 10.1021/jo990089v  1
1999 Wipf P, Li W. Formation of Nine-Membered Lactams by Oxidative Ring Expansion of 4-Hydroxyhydroindoles: A Biomimetic Approach toward the Tuberostemonone Ring System? The Journal of Organic Chemistry. 64: 4576-4577. PMID 11674523 DOI: 10.1021/jo9905064  1
1999 Tamura K, Rice RL, Wipf P, Lazo JS. Dual G1 and G2/M phase inhibition by SC-alpha alpha delta 9, a combinatorially derived Cdc25 phosphatase inhibitor. Oncogene. 18: 6989-96. PMID 10597298 DOI: 10.1038/sj.onc.1203179  1
1999 Wipf P, Uto Y. Total synthesis of the putative structure of the marine metabolite trunkamide A Tetrahedron Letters. 40: 5165-5169. DOI: 10.1016/S0040-4039(99)00957-0  1
1999 Wipf P, Reeves JT. Synthesis and applications of a highly fluorous alkoxy ethyl ether protective group Tetrahedron Letters. 40: 5139-5142. DOI: 10.1016/S0040-4039(99)00883-7  1
1999 Wipf P, Reeves JT. Synthesis and applications of a fluorous THP protective group Tetrahedron Letters. 40: 4649-4652. DOI: 10.1016/S0040-4039(99)00866-7  1
1998 Wipf P, Rahman LT, Rector SR. A General Strategy for Five-Membered Heterocycle Synthesis by Cycloelimination of Alkynyl Ketones, Amides, and Thioamides. The Journal of Organic Chemistry. 63: 7132-7133. PMID 11672349 DOI: 10.1021/jo981542q  0.68
1998 Kondru RK, Wipf P, Beratan DN. Atomic contributions to the optical rotation angle as a quantitative probe of molecular chirality. Science (New York, N.Y.). 282: 2247-50. PMID 9856945 DOI: 10.1126/science.282.5397.2247  1
1998 Kondru RK, Wipf P, Beratan DN. Theory-assisted determination of absolute stereochemistry for complex natural products via computation of molar rotation angles [17] Journal of the American Chemical Society. 120: 2204-2205. DOI: 10.1021/ja973690o  1
1997 Rice RL, Rusnak JM, Yokokawa F, Yokokawa S, Messner DJ, Boynton AL, Wipf P, Lazo JS. A targeted library of small-molecule, tyrosine, and dual-specificity phosphatase inhibitors derived from a rational core design and random side chain variation. Biochemistry. 36: 15965-74. PMID 9398331 DOI: 10.1021/bi971338h  1
1997 Kondru RK, Lim S, Wipf P, Beratan DN. Synthetic and model computational studies of molar rotation additivity for interacting chiral centers: a reinvestigation of van't Hoff's principle. Chirality. 9: 469-77. PMID 9329177 DOI: 10.1002/(SICI)1520-636X(1997)9:5/6<469::AID-CHIR13>3.0.CO;2-M  1
1997 Wipf P, Cunningham A, Rice RL, Lazo JS. Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors. Bioorganic & Medicinal Chemistry. 5: 165-77. PMID 9043668 DOI: 10.1016/S0968-0896(96)00199-X  1
1996 Wipf P, Xu W. Total Synthesis of the Antimitotic Marine Natural Product (+)-Curacin A. The Journal of Organic Chemistry. 61: 6556-6562. PMID 11667520 DOI: 10.1021/jo960845m  0.68
1996 Wipf P, Li W, Adeyeye CM, Rusnak JM, Lazo JS. Synthesis of chemoreversible prodrugs of ara-C with variable time-release profiles. Biological evaluation of their apoptotic activity. Bioorganic & Medicinal Chemistry. 4: 1585-96. PMID 8931928 DOI: 10.1016/0968-0896(96)00153-8  1
1996 Wipf P, Venkatraman S. A new thiazole synthesis by cyclocondensation of thioamides and alkynyl(aryl)iodonium reagents Journal of Organic Chemistry. 61: 8004-8005. DOI: 10.1021/jo961681c  1
1996 Wipf P, Venkatraman S. Total synthesis of (-)-muscoride A Journal of Organic Chemistry. 61: 6517-6522. DOI: 10.1021/jo960891m  1
1996 Wipf P, Venkatraman S. An improved protocol for azole synthesis with PEG-supported Burgess reagent Tetrahedron Letters. 37: 4659-4662. DOI: 10.1016/0040-4039(96)00918-5  1
1996 Goldstein DM, Wipf P. Studies toward the synthesis of Stemona alkaloids; a short synthesis of the tricyclic core of tuberostemonines Tetrahedron Letters. 37: 739-742. DOI: 10.1016/0040-4039(95)02302-X  1
1995 Wipf P, Venkatraman S. Total synthesis of (-)-thiangazole and structurally related polyazoles Journal of Organic Chemistry. 60: 7224-7229. DOI: 10.1021/jo00127a030  1
1995 Wipf P, Kim Y, Goldstein DM. Asymmetric total synthesis of the Stemona alkaloid (-)-stenine Journal of the American Chemical Society. 117: 11106-11112. DOI: 10.1021/ja00150a010  1
1995 Wipf P, Miller CP, Venkatraman S, Fritch PC. Thiolysis of oxazolines: A new, selective method for the direct conversion of peptide oxazolines into thiazolines Tetrahedron Letters. 36: 6395-6398. DOI: 10.1016/0040-4039(95)01322-9  1
1995 Wipf P, Venkatraman S, Miller CP. A new synthesis of α-methylserine by nucleophilic ring-opening of N-sulfonyl aziridines Tetrahedron Letters. 36: 3639-3642. DOI: 10.1016/0040-4039(95)00621-I  1
1991 Ireland RE, Wipf P, Xiang JN. Stereochemical control in the ester enolate Claisen rearrangement. 2. Chairlike vs boatlike transition-state selection Journal of Organic Chemistry. 56: 3572-3582. DOI: 10.1021/jo00011a023  1
1991 Ireland RE, Wipf P, Armstrong JD. Stereochemical control in the ester enolate Claisen rearrangement. 1. Stereoselectivity in silyl ketene acetal formation Journal of Organic Chemistry. 56: 650-657. DOI: 10.1021/jo00002a030  1
1991 Wipf P, Xu W, Smitrovich JH, Lehmann R, Venanzi LM. Copper-catalyzed conjugate additions of organozirconocenes. Synthetic and mechanistic studies. Tetrahedron. 50: 1935-1954. DOI: 10.1016/S0040-4020(01)85058-4  1
1990 Ireland RE, Wipf P, Roper TD. Use of a masked aldol unit in the synthesis of the right side of FK-506 Journal of Organic Chemistry. 55: 2284-2285. DOI: 10.1021/jo00295a009  1
1990 Ireland RE, Wipf P. Carboalumination of 1-alkynes and in situ transmetalation to higher order cyanocuprates. Stereospecific synthesis of tri- and disubstituted olefins by conjugate addition to enones Journal of Organic Chemistry. 55: 1425-1426. DOI: 10.1021/jo00292a009  1
1990 Ireland RE, Wipf P, Miltz W, Vanasse B. Methodology for the enantioselective synthesis of aldols and other 1,3-dioxygenated systems Journal of Organic Chemistry. 55: 1423-1424. DOI: 10.1021/jo00292a008  1
1989 Ireland RE, Wipf P. Studies directed towards the total synthesis of FK-506 preparation of a C(1) to C(15) segment Tetrahedron Letters. 30: 919-922. DOI: 10.1016/S0040-4039(00)95278-X  1
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