William R. Roush - Publications

Affiliations: 
1978-1987 Massachusetts Institute of Technology, Cambridge, MA, United States 
 1987-1997 Indiana University, Bloomington, Bloomington, IN, United States 
 1997-2004 University of Michigan, Ann Arbor, Ann Arbor, MI 
 2004- Chemistry Scripps Research Institute Florida 
Area:
Medicinal Chemistry
Website:
http://www.scripps.edu/roush/Roush.html

209 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Hwang D, Nilchan N, Nanna AR, Li X, Cameron MD, Roush WR, Park H, Rader C. Site-Selective Antibody Functionalization via Orthogonally Reactive Arginine and Lysine Residues. Cell Chemical Biology. PMID 31231031 DOI: 10.1016/j.chembiol.2019.05.010  0.32
2019 Doebelin C, He Y, Campbell S, Nuhant P, Kumar N, Koenig M, Garcia-Ordonez R, Chang MR, Roush WR, Lin L, Kahn S, Cameron MD, Griffin PR, Solt LA, Kamenecka TM. Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related receptor-α. Medicinal Chemistry (Shariqah (United Arab Emirates)). PMID 30799793 DOI: 10.2174/1573406415666190222124745  1
2018 Fuerst R, Yong Choi J, Knapinska AM, Smith L, Cameron MD, Ruiz C, Fields GB, Roush WR. Development of matrix metalloproteinase-13 inhibitors - A structure-activity/structure-property relationship study. Bioorganic & Medicinal Chemistry. PMID 30249495 DOI: 10.1016/j.bmc.2018.08.020  0.32
2018 Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nature Reviews. Drug Discovery. PMID 30116046 DOI: 10.1038/nrd.2018.149  0.44
2018 Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E. Targeting the NLRP3 inflammasome in inflammatory diseases. Nature Reviews. Drug Discovery. PMID 30026524 DOI: 10.1038/nrd.2018.97  0.44
2018 Zyserman I, Mondal D, Sarabia F, McKerrow JH, Roush WR, Debnath A. Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri. Experimental Parasitology. PMID 29551628 DOI: 10.1016/j.exppara.2018.03.010  0.48
2017 Calvet CM, Choi JY, Thomas D, Suzuki B, Hirata K, Lostracco-Johnson S, de Mesquita LB, Nogueira A, Meuser-Batista M, Silva TA, Siqueira-Neto JL, Roush WR, de Souza Pereira MC, McKerrow JH, Podust LM. 4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection. Plos Neglected Tropical Diseases. 11: e0006132. PMID 29281643 DOI: 10.1371/journal.pntd.0006132  0.48
2017 Allais C, Roush WR. Enantio- and Diastereoselective Synthesis of 1,5-syn-(Z)-Amino Alcohols via Imine Double Allylboration: Synthesis of trans-1,2,3,6-Tetrahydropyridines and Total Synthesis of Andrachcine. Organic Letters. PMID 28471668 DOI: 10.1021/acs.orglett.7b00995  1
2016 Walseng E, Nelson CG, Qi J, Nanna AR, Roush WR, Goswami RK, Sinha SC, Burke TR, Rader C. Chemically programmed bispecific antibodies in diabody format. The Journal of Biological Chemistry. PMID 27445334 DOI: 10.1074/jbc.M116.745588  1
2016 Nair RN, Mishra JK, Li F, Tortosa M, Yang C, Doherty JR, Cameron M, Cleveland JL, Roush WR, Bannister TD. Exploiting the co-reliance of tumours upon transport of amino acids and lactate: Gln and Tyr conjugates of MCT1 inhibitors. Medchemcomm. 7: 900-905. PMID 27347360 DOI: 10.1039/C5MD00579E  1
2016 Jones BD, Tochowicz A, Tang Y, Cameron MD, McCall LI, Hirata K, Siqueira-Neto JL, Reed SL, McKerrow JH, Roush WR. Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. Acs Medicinal Chemistry Letters. 7: 77-82. PMID 26819670 DOI: 10.1021/acsmedchemlett.5b00336  1
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, ... ... Roush WR, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/j.cell.2015.05.023  0.32
2015 Ghalei H, Schaub FX, Doherty JR, Noguchi Y, Roush WR, Cleveland JL, Stroupe ME, Karbstein K. Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth. The Journal of Cell Biology. 208: 745-59. PMID 25778921 DOI: 10.1083/jcb.201409056  1
2015 McCall LI, El Aroussi A, Choi JY, Vieira DF, De Muylder G, Johnston JB, Chen S, Kellar D, Siqueira-Neto JL, Roush WR, Podust LM, McKerrow JH. Targeting Ergosterol biosynthesis in Leishmania donovani: essentiality of sterol 14 alpha-demethylase. Plos Neglected Tropical Diseases. 9: e0003588. PMID 25768284 DOI: 10.1371/journal.pntd.0003588  1
2015 Wang Y, Stowe RL, Pinello CE, Tian G, Madoux F, Li D, Zhao LY, Li JL, Wang Y, Wang Y, Ma H, Hodder P, Roush WR, Liao D. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chemistry & Biology. 22: 273-84. PMID 25699604 DOI: 10.1016/j.chembiol.2014.12.015  0.32
2015 Penas C, Mishra JK, Wood SD, Schürer SC, Roush WR, Ayad NG. GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation. Cell Cycle (Georgetown, Tex.). 14: 417-24. PMID 25616418 DOI: 10.4161/15384101.2014.974439  1
2015 Corzo CA, Mari Y, Chang MR, Khan T, Kuruvilla D, Nuhant P, Kumar N, West GM, Duckett DR, Roush WR, Griffin PR. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Molecular Pharmacology. 87: 296-304. PMID 25473120 DOI: 10.1124/mol.114.095554  1
2014 Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51. Journal of Medicinal Chemistry. 57: 10162-75. PMID 25393646 DOI: 10.1021/jm501568b  1
2014 Choi JY, Podust LM, Roush WR. Drug Strategies Targeting CYP51 in Neglected Tropical Diseases. Chemical Reviews. PMID 25337991 DOI: 10.1021/cr5003134  1
2014 Spicer TP, Jiang J, Taylor AB, Choi JY, Hart PJ, Roush WR, Fields GB, Hodder PS, Minond D. Characterization of selective exosite-binding inhibitors of matrix metalloproteinase 13 that prevent articular cartilage degradation in vitro. Journal of Medicinal Chemistry. 57: 9598-611. PMID 25330343 DOI: 10.1021/jm501284e  1
2014 Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. Journal of Medicinal Chemistry. 57: 6989-7005. PMID 25101801 DOI: 10.1021/jm500448u  1
2014 Wang H, Yang C, Doherty JR, Roush WR, Cleveland JL, Bannister TD. Synthesis and structure-activity relationships of pteridine dione and trione monocarboxylate transporter 1 inhibitors. Journal of Medicinal Chemistry. 57: 7317-24. PMID 25068893 DOI: 10.1021/jm500640x  1
2014 Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi. Acs Medicinal Chemistry Letters. 5: 434-9. PMID 24900854 DOI: 10.1021/ml500010m  1
2014 Penas C, Ramachandran V, Simanski S, Lee C, Madoux F, Rahaim RJ, Chauhan R, Barnaby O, Schurer S, Hodder P, Steen J, Roush WR, Ayad NG. Casein kinase 1δ-dependent Wee1 protein degradation. The Journal of Biological Chemistry. 289: 18893-903. PMID 24817118 DOI: 10.1074/jbc.M114.547661  1
2014 Vieira DF, Choi JY, Roush WR, Podust LM. Expanding the binding envelope of CYP51 inhibitors targeting Trypanosoma cruzi with 4-aminopyridyl-based sulfonamide derivatives. Chembiochem : a European Journal of Chemical Biology. 15: 1111-20. PMID 24771705 DOI: 10.1002/cbic.201402027  1
2014 Doherty JR, Yang C, Scott KE, Cameron MD, Fallahi M, Li W, Hall MA, Amelio AL, Mishra JK, Li F, Tortosa M, Genau HM, Rounbehler RJ, Lu Y, Dang CV, ... ... Roush WR, et al. Blocking lactate export by inhibiting the Myc target MCT1 Disables glycolysis and glutathione synthesis. Cancer Research. 74: 908-20. PMID 24285728 DOI: 10.1158/0008-5472.CAN-13-2034  1
2014 El Hilali X, Roush WR. Enantio- and diastereoselective synthesis of syn-β-hydroxy-α-alkenyl carboxamides via reductive aldol reactions of morpholine 4-methyl-2,3-pentadienoic carboxamide with diisopinocampheylborane Tetrahedron Letters. DOI: 10.1016/j.tetlet.2015.01.018  1
2013 Allais C, Tsai AS, Nuhant P, Roush WR. Generation of stereochemically defined tetrasubstituted enolborinates by 1,4-hydroboration of α,β-unsaturated morpholine carboxamides with (diisopinocampheyl)borane. Angewandte Chemie (International Ed. in English). 52: 12888-91. PMID 24281884 DOI: 10.1002/anie.201307302  1
2013 Kister J, Ess DH, Roush WR. Enantio- and diastereoselective synthesis of syn-β-hydroxy-α-vinyl carboxylic esters via reductive aldol reactions of ethyl allenecarboxylate with 10-TMS-9-Borabicyclo[3.3.2]decane and DFT analysis of the hydroboration pathway. Organic Letters. 15: 5436-9. PMID 24138187 DOI: 10.1021/ol4025277  1
2013 Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents. Journal of Medicinal Chemistry. 56: 7651-68. PMID 24079662 DOI: 10.1021/jm401067s  1
2013 Chen M, Roush WR. Enantiodivergent hydroboration reactions of a racemic allenylsilane with diisopinocampheylborane and Curtin-Hammett controlled double asymmetric crotylboration reactions of (S)-E-αphenyldimethylsilyl( (d) diisopinocampheyl)-crotylborane. Tetrahedron. 69: 7551-7558. PMID 24068848 DOI: 10.1016/j.tet.2013.06.053  1
2013 Chen M, Roush WR. Enantiodivergent Hydroboration Reactions of a Racemic Allenylsilane with Diisopinocampheylborane and Curtin-Hammett Controlled Double Asymmetric Crotylboration Reactions of (S)-E-α-phenyldimethylsilyl( (d) diisopinocampheyl)-crotylborane. Tetrahedron. 69: 5468-5475. PMID 24039304 DOI: 10.1016/j.tet.2013.04.098  1
2013 Allais C, Nuhant P, Roush WR. (Diisopinocampheyl)borane-mediated reductive aldol reactions of acrylate esters: enantioselective synthesis of anti-aldols. Organic Letters. 15: 3922-5. PMID 23885946 DOI: 10.1021/ol401679g  1
2013 Nuhant P, Allais C, Roush WR. Diisopinocampheylborane-mediated reductive aldol reactions: highly enantio- and diastereoselective synthesis of syn aldols from N-acryloylmorpholine. Angewandte Chemie (International Ed. in English). 52: 8703-7. PMID 23818095 DOI: 10.1002/anie.201302535  1
2013 Bibian M, Rahaim RJ, Choi JY, Noguchi Y, Schürer S, Chen W, Nakanishi S, Licht K, Rosenberg LH, Li L, Feng Y, Cameron MD, Duckett DR, Cleveland JL, Roush WR. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorganic & Medicinal Chemistry Letters. 23: 4374-80. PMID 23787102 DOI: 10.1016/j.bmcl.2013.05.075  1
2013 Chen M, Roush WR. Enantioselective synthesis of (Z)- and (E)-2-methyl-1,5-anti-pentenediols via an allene hydroboration-double-allylboration reaction sequence. Journal of the American Chemical Society. 135: 9512-7. PMID 23758559 DOI: 10.1021/ja4033633  1
2013 Yang H, Pinello CE, Luo J, Li D, Wang Y, Zhao LY, Jahn SC, Saldanha SA, Chase P, Planck J, Geary KR, Ma H, Law BK, Roush WR, Hodder P, et al. Small-molecule inhibitors of acetyltransferase p300 identified by high-throughput screening are potent anticancer agents. Molecular Cancer Therapeutics. 12: 610-20. PMID 23625935 DOI: 10.1158/1535-7163.MCT-12-0930  0.32
2013 Tsai AS, Chen M, Roush WR. Chiral Brønsted Acid Catalyzed Enantioselective Synthesis of anti-Homopropargyl Alcohols via Kinetic Resolution-Aldehyde Allenylboration Using Racemic Allenylboronates. Organic Letters. 15: 2325. PMID 23578147 DOI: 10.1021/ol400932e  0.88
2013 Chen M, Roush WR. Enantioselective synthesis of (E)-δ-silyl-anti-homoallylic alcohols via an enantiodivergent hydroboration-crotylboration reaction of a racemic allenylsilane. Organic Letters. 15: 1662-5. PMID 23534391 DOI: 10.1021/ol4004405  1
2013 Nuhant P, Roush WR. Enantio- and diastereoselective synthesis of N-acetyl dihydrotetrafibricin methyl ester. Journal of the American Chemical Society. 135: 5340-3. PMID 23530855 DOI: 10.1021/ja401918r  1
2013 Tsai AS, Chen M, Roush WR. Chiral Brønsted acid catalyzed enantioselective synthesis of anti-homopropargyl alcohols via kinetic resolution-aldehyde allenylboration using racemic allenylboronates. Organic Letters. 15: 1568-71. PMID 23484801 DOI: 10.1021/ol4003459  1
2013 Geist JG, Barth R, Roush WR. Enantioselective synthesis of the C1-C11 fragment of tedanolide C. Organic Letters. 15: 58-61. PMID 23249423 DOI: 10.1021/ol303089w  1
2013 Abbott JR, Roush WR. Stereoselective synthesis of the disaccharide unit of incednine. Organic Letters. 15: 62-4. PMID 23249392 DOI: 10.1021/ol303093z  1
2013 Chen M, Roush WR. Crotylboron-based synthesis of the polypropionate units of chaxamycins A/D, salinisporamycin, and rifamycin S. The Journal of Organic Chemistry. 78: 3-8. PMID 22703288 DOI: 10.1021/jo3008226  1
2012 Dossey AT, Whitaker JM, Dancel MC, Vander Meer RK, Bernier UR, Gottardo M, Roush WR. Defensive spiroketals from Asceles glaber (Phasmatodea): absolute configuration and effects on ants and mosquitoes. Journal of Chemical Ecology. 38: 1105-15. PMID 22976590 DOI: 10.1007/s10886-012-0183-x  0.32
2012 Chen M, Roush WR. Enantioselective synthesis of anti- and syn-homopropargyl alcohols via chiral Brønsted acid catalyzed asymmetric allenylboration reactions. Journal of the American Chemical Society. 134: 10947-52. PMID 22731887 DOI: 10.1021/ja3031467  1
2012 Han JL, Chen M, Roush WR. Diastereo- and enantioselective synthesis of (E)-2-Methyl-1,2-syn- and (E)-2-Methyl-1,2-anti-3-pentenediols via allenylboronate kinetic resolution with ((d)Ipc)2BH and aldehyde allylboration. Organic Letters. 14: 3028-31. PMID 22646839 DOI: 10.1021/ol3010968  1
2012 Chen M, Roush WR. Enantioselective synthesis of (+)-crocacin C. An example of a highly challenging mismatched double asymmetric δ-stannylcrotylboration reaction. Organic Letters. 14: 1880-3. PMID 22409510 DOI: 10.1021/ol300476f  1
2012 Chen M, Roush WR. Enantioselective synthesis of (-)-basiliskamide A. Organic Letters. 14: 1556-9. PMID 22372693 DOI: 10.1021/ol300282e  1
2012 Chen M, Roush WR. Highly stereoselective synthesis of anti,anti-dipropionate stereotriads: a solution to the long-standing problem of challenging mismatched double asymmetric crotylboration reactions. Journal of the American Chemical Society. 134: 3925-31. PMID 22332989 DOI: 10.1021/ja300472a  1
2012 Choi JY, Plummer MS, Starr J, Desbonnet CR, Soutter H, Chang J, Miller JR, Dillman K, Miller AA, Roush WR. Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation. Journal of Medicinal Chemistry. 55: 852-70. PMID 22243413 DOI: 10.1021/jm201349f  1
2012 Chen M, Roush WR. Total synthesis of (-)-tirandamycin C. Organic Letters. 14: 426-8. PMID 22148850 DOI: 10.1021/ol203161u  1
2012 Sun H, Roush WR. Synthesis of (S,S)-diisopropyl tartrate (E)-crotylboronate and its reaction with aldehydes: (2r,3r,4r)-1,2-dideoxy-2-ethenyl-4,5-o-(1-methylethylidene)- xylitol Organic Syntheses. 88: 181-196. DOI: 10.15227/orgsyn.088.0181  1
2011 Sun H, Roush WR, Hughes D. SYNTHESIS OF (+)-B-ALLYLDIISOPINOCAMPHEYLBORANE AND ITS REACTION WITH ALDEHYDES. Organic Syntheses; An Annual Publication of Satisfactory Methods For the Preparation of Organic Chemicals. 88: 87-102. PMID 22962503 DOI: 10.15227/orgsyn.088.0087  1
2011 Ying M, Roush WR. Studies on the Synthesis of Reidispongiolide A: Stereoselective Synthesis of the C(22)-C(36) Fragment. Tetrahedron. 67: 10274-10280. PMID 22711935 DOI: 10.1016/j.tet.2011.10.029  1
2011 Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR. Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds. Bioorganic & Medicinal Chemistry Letters. 21: 7180-4. PMID 22018790 DOI: 10.1016/j.bmcl.2011.09.077  1
2011 Nuhant P, Kister J, Lira R, Sorg A, Roush WR. Development of a Double Allylboration Reagent Targeting 1,5-syn-(E)-Diols: Application to the Synthesis of the C(23)-C(40) Fragment of Tetrafibricin. Tetrahedron. 67: 6497-6512. PMID 21857752 DOI: 10.1016/j.tet.2011.06.008  1
2011 Zhou Y, Agudelo J, Lu K, Goetz DH, Hansell E, Chen YT, Roush WR, McKerrow J, Craik CS, Amberg SM, Simmons G. Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. Antiviral Research. 92: 187-94. PMID 21820471 DOI: 10.1016/j.antiviral.2011.07.016  1
2011 Sun H, Roush WR, Candito DA, Blanchot M, Lautens M. SYNTHESIS OF (S,S)-DIISOPROPYL TARTRATE (E)-CROTYLBORONATE AND ITS REACTION WITH ALDEHYDES: (2R,3R,4R)-1,2-DIDEOXY-2-ETHENYL-4,5-O-(1-METHYLETHYLIDENE)-XYLITOL. Organic Syntheses; An Annual Publication of Satisfactory Methods For the Preparation of Organic Chemicals. 88: 181-196. PMID 21666877  1
2011 Sun H, Abbott JR, Roush WR. Stereoselective synthesis of a model C(18)-C(35) spiroketal fragment of integramycin. Organic Letters. 13: 2734-7. PMID 21510632 DOI: 10.1021/ol200834p  1
2011 Halvorsen GT, Roush WR. Stereoselective Synthesis of the Decahydrofluorene Core of the Hirsutellones. Tetrahedron Letters. 52: 2072-2075. PMID 21503271 DOI: 10.1016/j.tetlet.2010.10.111  1
2011 Solt LA, Kumar N, Nuhant P, Wang Y, Lauer JL, Liu J, Istrate MA, Kamenecka TM, Roush WR, Vidovi? D, Schürer SC, Xu J, Wagoner G, Drew PD, Griffin PR, et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand. Nature. 472: 491-4. PMID 21499262 DOI: 10.1038/nature10075  1
2011 Chen M, Roush WR. Enantioconvergent hydroboration of a racemic allene: enantioselective synthesis of (E)-δ-stannyl-anti-homoallylic alcohols via aldehyde crotylboration. Journal of the American Chemical Society. 133: 5744-7. PMID 21449594 DOI: 10.1021/ja2010187  1
2011 Lee Y, Choi JY, Fu H, Harvey C, Ravindran S, Roush WR, Boothroyd JC, Khosla C. Chemistry and biology of macrolide antiparasitic agents. Journal of Medicinal Chemistry. 54: 2792-804. PMID 21428405 DOI: 10.1021/jm101593u  1
2011 Chen M, Roush WR. Enantioselective syntheses of syn- and anti-β-hydroxyallylsilanes via allene hydroboration-aldehyde allylboration reactions. Organic Letters. 13: 1992-5. PMID 21410173 DOI: 10.1021/ol200392u  1
2011 Busby SA, Kumar N, Kuruvilla DS, Istrate MA, Conkright JJ, Wang Y, Kamenecka TM, Cameron MD, Roush WR, Burris TP, Griffin PR. Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors. Acs Chemical Biology. 6: 618-27. PMID 21381756 DOI: 10.1021/cb100396s  1
2011 Kister J, Nuhant P, Lira R, Sorg A, Roush WR. Enantio- and diastereoselective synthesis of (E)-1,5-syn-diols: application to the synthesis of the C(23)-C(40) fragment of tetrafibricin. Organic Letters. 13: 1868-71. PMID 21375316 DOI: 10.1021/ol2003836  1
2011 Stewart PS, Chen M, Roush WR, Ess DH. Thermodynamic control of 1,3-boratropic shifts of α- and γ-stannyl-substituted allylboranes: hyperconjugation outweighs steric effects. Organic Letters. 13: 1478-81. PMID 21323387 DOI: 10.1021/ol2001599  1
2011 Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. Acs Chemical Biology. 6: 218-22. PMID 21090593 DOI: 10.1021/cb1002762  1
2010 Chen YT, Brinen LS, Kerr ID, Hansell E, Doyle PS, McKerrow JH, Roush WR. In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. Plos Neglected Tropical Diseases. 4. PMID 20856868 DOI: 10.1371/journal.pntd.0000825  1
2010 Winbush SM, Roush WR. Enantioselective synthesis of (Z)-1,2-anti-2,5-anti-triol monosilyl ethers using a cross-metathesis allylboration sequence. Organic Letters. 12: 4344-7. PMID 20806914 DOI: 10.1021/ol101789g  1
2010 Wang Y, Kumar N, Nuhant P, Cameron MD, Istrate MA, Roush WR, Griffin PR, Burris TP. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. Acs Chemical Biology. 5: 1029-34. PMID 20735016 DOI: 10.1021/cb100223d  1
2010 Gianni D, Taulet N, Zhang H, DerMardirossian C, Kister J, Martinez L, Roush WR, Brown SJ, Bokoch GM, Rosen H. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. Acs Chemical Biology. 5: 981-93. PMID 20715845 DOI: 10.1021/cb100219n  1
2010 Madoux F, Simanski S, Chase P, Mishra JK, Roush WR, Ayad NG, Hodder P. An ultra-high throughput cell-based screen for wee1 degradation inhibitors. Journal of Biomolecular Screening. 15: 907-17. PMID 20660794 DOI: 10.1177/1087057110375848  1
2010 Chen M, Ess DH, Roush WR. Enantioselective synthesis of (E)-delta-stannyl homoallylic alcohols via aldehyde allylboration using alpha-stannylallylboranes generated by allene hydroboration followed by a highly diastereoselective 1,3-boratropic shift. Journal of the American Chemical Society. 132: 7881-3. PMID 20496899 DOI: 10.1021/ja103041u  1
2010 Chen M, Roush WR. Highly (E)-selective BF(3).Et(2)O-promoted allylboration of chiral nonracemic alpha-substituted allylboronates and analysis of the origin of stereocontrol. Organic Letters. 12: 2706-9. PMID 20476769 DOI: 10.1021/ol1007444  1
2010 Barth R, Roush WR. Enantioselective synthesis of alpha-methylene-beta-hydroxy carboxylic acid derivatives via a diastereoselective aldol/beta-elimination sequence: application to the C(15)-C(21) fragment of tedanolide C. Organic Letters. 12: 2342-5. PMID 20405855 DOI: 10.1021/ol1006955  1
2010 He C, Nora GP, Schneider EL, Kerr ID, Hansell E, Hirata K, Gonzalez D, Sajid M, Boyd SE, Hruz P, Cobo ER, Le C, Liu WT, Eckmann L, Dorrestein PC, ... ... Roush WR, et al. A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target. The Journal of Biological Chemistry. 285: 18516-27. PMID 20378535 DOI: 10.1074/jbc.M109.086181  1
2009 Ess DH, Kister J, Chen M, Roush WR. Origin of thermodynamic versus kinetic control of allene hydroboration with 9-borabicyclo[3.3.1]nonane and 10(R)-trimethylsilyl-9-borabicyclo[3.3.2]decane. Organic Letters. 11: 5538-41. PMID 19899749 DOI: 10.1021/ol902364d  1
2009 Ess DH, Kister J, Chen M, Roush WR. Quantum-mechanical study of 10-R-9-borabicyclo[3.3.2]decane alkene hydroboration. The Journal of Organic Chemistry. 74: 8626-37. PMID 19824624 DOI: 10.1021/jo901737d  1
2009 Chen M, Handa M, Roush WR. Enantioselective synthesis of 2-methyl-1,2-syn- and 2-methyl-1,2-anti-3-butenediols via allene hydroboration-aldehyde allylboration reaction sequences. Journal of the American Chemical Society. 131: 14602-3. PMID 19778012 DOI: 10.1021/ja904599h  1
2009 Kister J, DeBaillie AC, Lira R, Roush WR. Stereoselective synthesis of gamma-substituted (Z)-allylic boranes via kinetically controlled hydroboration of allenes with 10-TMS-9-borabicyclo[3.3.2]decane. Journal of the American Chemical Society. 131: 14174-5. PMID 19775159 DOI: 10.1021/ja905494c  1
2009 Dossey AT, Gottardo M, Whitaker JM, Roush WR, Edison AS. Alkyldimethylpyrazines in the defensive spray of Phyllium westwoodii: a first for order Phasmatodea. Journal of Chemical Ecology. 35: 861-70. PMID 19685263 DOI: 10.1007/s10886-009-9666-9  0.32
2009 Li F, Roush WR. Stereoselective synthesis of syn,syn- and syn,anti-1,3,5-triols via intramolecular hydrosilylation of substituted pent-3-en-1,5-diols. Organic Letters. 11: 2932-5. PMID 19507846 DOI: 10.1021/ol9009877  1
2008 Dunetz JR, Julian LD, Newcom JS, Roush WR. Total syntheses of (+)-tedanolide and (+)-13-deoxytedanolide. Journal of the American Chemical Society. 130: 16407-16. PMID 18980317 DOI: 10.1021/ja8063205  1
2008 Tortosa M, Yakelis NA, Roush WR. Total synthesis of (+)-superstolide A. The Journal of Organic Chemistry. 73: 9657-67. PMID 18956845 DOI: 10.1021/jo801794s  1
2008 Halvorsen GT, Roush WR. Siloxacyclopentenes as dienophile-linked directing groups in intramolecular Diels-Alder reactions. Organic Letters. 10: 5313-6. PMID 18954061 DOI: 10.1021/ol802266s  1
2008 Bates RH, Chen M, Roush WR. Applications of chiral allylmetallating agents toward the synthesis of oxygen heterocyles. Current Opinion in Drug Discovery & Development. 11: 778-92. PMID 18946843  1
2008 Pragani R, Roush WR. Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone. Organic Letters. 10: 4613-6. PMID 18808128 DOI: 10.1021/ol8018727  1
2008 Bates RH, Shotwell JB, Roush WR. Stereoselective syntheses of the C(1)-C(9) fragment of amphidinolide C. Organic Letters. 10: 4343-6. PMID 18783230 DOI: 10.1021/ol801852j  1
2008 Huh CW, Roush WR. Highly stereoselective and modular syntheses of 10-hydroxytrilobacin and three diastereomers via stereodivergent [3 + 2]-annulation reactions. Organic Letters. 10: 3371-4. PMID 18588305 DOI: 10.1021/ol801242d  1
2008 Chen YT, Lira R, Hansell E, McKerrow JH, Roush WR. Synthesis of macrocyclic trypanosomal cysteine protease inhibitors. Bioorganic & Medicinal Chemistry Letters. 18: 5860-3. PMID 18585034 DOI: 10.1016/j.bmcl.2008.06.012  1
2008 Dunetz JR, Roush WR. Concerning the synthesis of the tedanolide C(13)-C(23) fragment via anti-aldol reaction. Organic Letters. 10: 2059-62. PMID 18422319 DOI: 10.1021/ol800546g  1
2008 Roth J, Madoux F, Hodder P, Roush WR. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds. Bioorganic & Medicinal Chemistry Letters. 18: 2628-32. PMID 18374567 DOI: 10.1016/j.bmcl.2008.03.027  1
2008 Tortosa M, Yakelis NA, Roush WR. Total synthesis of +-superstolide A. Journal of the American Chemical Society. 130: 2722-3. PMID 18254629 DOI: 10.1021/ja710238h  1
2008 Winbush SM, Mergott DJ, Roush WR. Total synthesis of (-)-spinosyn A: examination of structural features that govern the stereoselectivity of the key transannular Diels-Alder reaction. The Journal of Organic Chemistry. 73: 1818-29. PMID 18215065 DOI: 10.1021/jo7024515  1
2008 Hicks JD, Roush WR. Synthesis of the C(26)-C(42) and C(43)-C(67) pyran-containing fragments of amphidinol 3 via a common pyran intermediate. Organic Letters. 10: 681-4. PMID 18205377 DOI: 10.1021/ol703042q  1
2008 Handa M, Smith WJ, Roush WR. Studies on the synthesis of apoptolidin A. 2. Synthesis of the disaccharide unit. The Journal of Organic Chemistry. 73: 1036-9. PMID 18163646 DOI: 10.1021/jo7022526  1
2008 Handa M, Scheidt KA, Bossart M, Zheng N, Roush WR. Studies on the synthesis of apoptolidin A. 1. Synthesis of the C(1)-C(11) fragment. The Journal of Organic Chemistry. 73: 1031-5. PMID 18163645 DOI: 10.1021/jo702250z  1
2007 Va P, Roush WR. Total Synthesis of Amphidinolide E and Amphidinolide E Stereoisomers. Tetrahedron. 63: 5768-5796. PMID 18575572 DOI: 10.1016/j.tet.2007.02.058  1
2007 Hicks JD, Huh CW, Legg AD, Roush WR. Concerning the selective protection of (Z)-1,5-syn-ene-diols and (E)-1,5-anti-ene-diols as allylic triethylsilyl ethers. Organic Letters. 9: 5621-4. PMID 18027963 DOI: 10.1021/ol702588h  1
2007 Lira R, Roush WR. Enantio- and diastereoselective synthesis of syn-beta-hydroxyallylsilanes via a chiral (Z)-gamma-silylallylboronate. Organic Letters. 9: 4315-8. PMID 17867698 DOI: 10.1021/ol7018746  1
2007 Goetz DH, Choe Y, Hansell E, Chen YT, McDowell M, Jonsson CB, Roush WR, McKerrow J, Craik CS. Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus. Biochemistry. 46: 8744-52. PMID 17605471 DOI: 10.1021/bi0621415  1
2007 Meléndez-López SG, Herdman S, Hirata K, Choi MH, Choe Y, Craik C, Caffrey CR, Hansell E, Chávez-Munguía B, Yen TC, Roush WR, McKerrow J, Eckmann L, Guo J, Stanley SL, et al. Use of recombinant Entamoeba histolytica cysteine proteinase 1 to identify a potent inhibitor of amebic invasion in a human colonic model Eukaryotic Cell. 6: 1130-1136. PMID 17513563 DOI: 10.1128/EC.00094-07  1
2007 Halvorsen GT, Roush WR. Intramolecular diels-alder reactions of siloxacyclopentene constrained trienes Organic Letters. 9: 2243-2246. PMID 17480094 DOI: 10.1021/ol070858u  1
2007 Lira R, Roush WR. Stereoselective synthesis of the C(1)-C(19) fragment of tetrafibricin Organic Letters. 9: 533-536. PMID 17249805 DOI: 10.1021/ol0629869  1
2007 Va P, Roush WR. Synthesis of 2-epi-amphidinolide E: An unexpected and highly selective C(2) inversion during an esterification reaction Organic Letters. 9: 307-310. PMID 17217291 DOI: 10.1021/ol0628098  1
2006 Va P, Roush WR. Total synthesis of amphidinolide E. Journal of the American Chemical Society. 128: 15960-1. PMID 17165709 DOI: 10.1021/ja066663j  1
2006 Trullinger TK, Qi J, Roush WR. Studies on the synthesis of quartromicins a(3) and d(3): synthesis of the vertical and horizontal bis-spirotetronate fragments. The Journal of Organic Chemistry. 71: 6915-22. PMID 16930045 DOI: 10.1021/jo061059c  1
2006 Qi J, Roush WR. Synthesis of precursors of the agalacto (exo) fragment of the quartromicins via an auxiliary-controlled exo-selective Diels-Alder reaction. Organic Letters. 8: 2795-8. PMID 16774259 DOI: 10.1021/ol0609208  1
2005 Flamme EM, Roush WR. Synthesis of 2,6-trans-disubstituted 5,6-dihydropyrans from (Z)-1,5-syn-endiols. Beilstein Journal of Organic Chemistry. 1: 7. PMID 16542020 DOI: 10.1186/1860-5397-1-7  1
2005 Dias LC, Aguilar AM, Salles AG, Steil LJ, Roush WR. Concerning the application of the1H NMR ABX analysis for assignment of stereochemistry to aldols deriving from aldehydes lacking β-branches Journal of Organic Chemistry. 70: 10461-10465. PMID 16323858 DOI: 10.1021/jo051773e  1
2005 Thalji RK, Roush WR. Remarkable phosphine-effect on the intramolecular aldol reactions of unsaturated 1,5-diketones: highly regioselective synthesis of cross-conjugated dienones. Journal of the American Chemical Society. 127: 16778-9. PMID 16316211 DOI: 10.1021/ja054085l  1
2005 Hicks JD, Flamme EM, Roush WR. Synthesis of the C(43)-C(67) fragment of amphidinol 3. Organic Letters. 7: 5509-12. PMID 16288543 DOI: 10.1021/ol052322j  1
2005 Lambert WT, Roush WR. Synthesis of the A-B subunit of angelmicin B. Organic Letters. 7: 5501-4. PMID 16288541 DOI: 10.1021/ol052321r  1
2005 Mertz E, Tinsley JM, Roush WR. [3 + 2]-annulation reactions of chiral allylsilanes and chiral aldehydes. studies on the synthesis of bis-tetrahydrofuran substructures of annonaceous acetogenins. The Journal of Organic Chemistry. 70: 8035-46. PMID 16277325 DOI: 10.1021/jo0511290  1
2005 Tinsley JM, Mertz E, Chong PY, Rarig RA, Roush WR. Synthesis of (+)-bullatacin via the highly diastereoselective [3+2] annulation reaction of a racemic aldehyde and a nonracemic allylsilane. Organic Letters. 7: 4245-8. PMID 16146398 DOI: 10.1021/ol051719k  1
2005 Tinsley JM, Roush WR. Total synthesis of asimicin via highly stereoselective [3 + 2] annulation reactions of substituted allylsilanes. Journal of the American Chemical Society. 127: 10818-9. PMID 16076173 DOI: 10.1021/ja051986l  1
2005 Heitzman CL, Lambert WT, Mertz E, Shotwell JB, Tinsley JM, Va P, Roush WR. Efficient protiodesilylation of unactivated C(sp3)-SiMe2Ph bonds using tetrabutylammonium fluoride. Organic Letters. 7: 2405-8. PMID 15932209 DOI: 10.1021/ol0506821  1
2005 Julian LD, Newcom JS, Roush WR. Total synthesis of (+)-13-deoxytedanolide. Journal of the American Chemical Society. 127: 6186-7. PMID 15853320 DOI: 10.1021/ja050729d  1
2005 Liu CM, Smith WJ, Gustin DJ, Roush WR. Experimental evidence for chair-like transition states in aldol reactions of methyl ketone lithium enolates: stereoselective synthesis and utilization of a deuterium-labeled enolate as a probe of reaction stereochemistry. Journal of the American Chemical Society. 127: 5770-1. PMID 15839658 DOI: 10.1021/ja050730c  1
2005 Flamme EM, Roush WR. Synthesis of the C(1)-C(25) fragment of amphidinol 3: application of the double-allylboration reaction for synthesis of 1,5-diols. Organic Letters. 7: 1411-4. PMID 15787519 DOI: 10.1021/ol050250q  1
2005 Dineen TA, Roush WR. Stereoselective synthesis of the octahydronaphthalene unit of integramycin via an intramolecular Diels-Alder reaction. Organic Letters. 7: 1355-8. PMID 15787505 DOI: 10.1021/ol050191g  1
2004 Shotwell JB, Roush WR. Synthesis of the C11-C29 fragment of amphidinolide F. Organic Letters. 6: 3865-8. PMID 15469369 DOI: 10.1021/ol048381z  1
2004 Narayan S, Roush WR. Studies toward the total synthesis of angelmicin B (hibarimicin B): synthesis of a model CD-D' arylnaphthoquinone. Organic Letters. 6: 3789-92. PMID 15469350 DOI: 10.1021/ol048436x  1
2004 Durham TB, Blanchard N, Savall BM, Powell NA, Roush WR. Total synthesis of formamicin. Journal of the American Chemical Society. 126: 9307-17. PMID 15281821 DOI: 10.1021/ja048493l  1
2004 Roush WR, Neitz RJ. Studies on the synthesis of landomycin A. Synthesis of the originally assigned structure of the aglycone, landomycinone, and revision of structure. The Journal of Organic Chemistry. 69: 4906-12. PMID 15255715 DOI: 10.1021/jo049426c  1
2004 Dineen TA, Roush WR. Total synthesis of cochleamycin A. Organic Letters. 6: 2043-6. PMID 15176814 DOI: 10.1021/ol049331x  1
2004 Mergott DJ, Frank SA, Roush WR. Total synthesis of (-)-spinosyn A. Proceedings of the National Academy of Sciences of the United States of America. 101: 11955-9. PMID 15173590 DOI: 10.1073/pnas.0401247101  1
2004 Methot JL, Roush WR. Nucleophilic phosphine organocatalysis Advanced Synthesis and Catalysis. 346: 1035-1050. DOI: 10.1002/adse.200404087  1
2004 Roush WR. Recent studies in carbonyl allylation reactions: Application to the synthesis of oxygen heterocycles Actualite Chimique. 21-22.  1
2003 Dineen TA, Roush WR. Probing the Lewis acid-catalyzed intramolecular Diels-Alder cyclizations of allylic alkoxy-substituted (Z)-1,3-dienes. Organic Letters. 5: 4725-8. PMID 14627425 DOI: 10.1021/ol035900+  1
2003 Methot JL, Roush WR. Synthetic studies toward FR182877. Remarkable solvent effect in the vinylogous morita-baylis-hillman cyclization. Organic Letters. 5: 4223-6. PMID 14572290 DOI: 10.1021/ol0357550  1
2003 Boitano A, Emal CD, Leonetti F, Blatt NB, Dineen TA, Ellman JA, Roush WR, Opipari AW, Glick GD. Structure activity studies of a novel cytotoxic benzodiazepine. Bioorganic & Medicinal Chemistry Letters. 13: 3327-30. PMID 12951119 DOI: 10.1016/S0960-894X(03)00683-8  1
2003 Reddick JJ, Cheng J, Roush WR. Relative rates of Michael reactions of 2'-(phenethyl)thiol with vinyl sulfones, vinyl sulfonate esters, and vinyl sulfonamides relevant to vinyl sulfonyl cysteine protease inhibitors. Organic Letters. 5: 1967-70. PMID 12762698 DOI: 10.1021/ol034555l  1
2003 Durham TB, Roush WR. Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B. Organic Letters. 5: 1875-8. PMID 12762675 DOI: 10.1021/ol034395d  1
2003 Durham TB, Roush WR. Stereoselective synthesis of 2-deoxy-beta-galactosides via 2-deoxy-2-bromo- and 2-deoxy-2-iodo-galactopyranosyl donors. Organic Letters. 5: 1871-4. PMID 12762674 DOI: 10.1021/ol034393t  1
2003 Yakelis NA, Roush WR. Synthesis of the C(21)-C(26) fragment of superstolide A: concerning the stereochemistry of (E)-crotylboration reactions of alaninal derivatives. The Journal of Organic Chemistry. 68: 3838-43. PMID 12737561 DOI: 10.1021/jo0341012  1
2003 Heo JN, Holson EB, Roush WR. Common-intermediate strategy for synthesis of conduritols and inositols via beta-hydroxy cyclohexenylsilanes. Organic Letters. 5: 1697-700. PMID 12735755 DOI: 10.1021/ol034349d  1
2003 Heo JN, Micalizio GC, Roush WR. Enantio- and diastereoselective synthesis of cyclic beta-hydroxy allylsilanes via sequential aldehyde gamma-silylallylboration and ring-closing metathesis reactions. Organic Letters. 5: 1693-6. PMID 12735754 DOI: 10.1021/ol034347t  1
2003 Chemler SR, Roush WR. Stereochemistry of the allylation and crotylation reactions of alpha-methyl-beta-hydroxy aldehydes with allyl- and crotyltrifluorosilanes. Synthesis of anti,anti-dipropionate stereotriads and stereodivergent pathways for the reactions with 2,3-anti- and 2,3-syn-alpha-methyl-beta-hydroxy aldehydes. The Journal of Organic Chemistry. 68: 1319-33. PMID 12585871 DOI: 10.1021/jo0267908  1
2003 Savall BM, Blanchard N, Roush WR. Total synthesis of the formamicin aglycon, formamicinone. Organic Letters. 5: 377-9. PMID 12556196 DOI: 10.1021/ol027569k  1
2003 Blanchard N, Roush WR. 2-Deoxy-2-iodo-beta-glucopyranosyl fluorides: mild and highly stereoselective glycosyl donors for the synthesis of 2-deoxy-beta-glycosides from beta-hydroxy ketones. Organic Letters. 5: 81-4. PMID 12509896 DOI: 10.1021/ol027257h  1
2003 Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD, Neitz RJ, Roush WR, Rosenthal PJ. Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. Antimicrobial Agents and Chemotherapy. 47: 154-60. PMID 12499184 DOI: 10.1128/AAC.47.1.154-160.2003  1
2002 Roush WR, Newcom JS. Studies on the synthesis of tedanolide. 2. Stereoselective synthesis of a protected C(1)-C(12) fragment. Organic Letters. 4: 4739-42. PMID 12489975 DOI: 10.1021/ol0272343  1
2002 Chong PY, Roush WR. Concerning the origin of the high beta-selectivity of glycosidation reactions of 2-deoxy-2-iodo-glucopyranosyl trichloroacetimidates. Organic Letters. 4: 4523-6. PMID 12465928 DOI: 10.1021/ol027066e  1
2002 Flamme EM, Roush WR. Enantioselective synthesis of 1,5-anti- and 1,5-syn-diols using a highly diastereoselective one-pot double allylboration reaction sequence. Journal of the American Chemical Society. 124: 13644-5. PMID 12431072 DOI: 10.1021/ja028055j  1
2002 Holson EB, Roush WR. Synthesis of the C(2)-C(13) fragment (the A-B spiroketal unit) of spongistatin 1 (altohyrtin A): use of a common intermediate for the synthesis of both spongistatin spiroketals. Organic Letters. 4: 3723-5. PMID 12375928 DOI: 10.1021/ol026688x  1
2002 Holson EB, Roush WR. Diastereoselective synthesis of the C(17)-C(28) fragment (the C-D spiroketal unit) of spongistatin 1 (altohyrtin A) via a kinetically controlled iodo-spiroketalization reaction. Organic Letters. 4: 3719-22. PMID 12375927  0.6
2002 Gung BW, Xue X, Roush WR. The origin of diastereofacial control in allylboration reactions using tartrate ester derived allylboronates: attractive interactions between the Lewis acid coordinated aldehyde carbonyl group and an ester carbonyl oxygen. Journal of the American Chemical Society. 124: 10692-7. PMID 12207523 DOI: 10.1021/ja026373c  1
2002 Mergott DJ, Frank SA, Roush WR. Application of the intramolecular vinylogous Morita-Baylis-Hillman reaction toward the synthesis of the spinosyn A tricyclic nucleus. Organic Letters. 4: 3157-60. PMID 12201741 DOI: 10.1021/ol026540d  1
2002 Hernandez AA, Roush WR. Recent advances in the synthesis, design and selection of cysteine protease inhibitors. Current Opinion in Chemical Biology. 6: 459-65. PMID 12133721 DOI: 10.1016/S1367-5931(02)00345-9  1
2002 Scheidt KA, Bannister TD, Tasaka A, Wendt MD, Savall BM, Fegley GJ, Roush WR. Total synthesis of (-)-bafilomycin A(1). Journal of the American Chemical Society. 124: 6981-90. PMID 12059221 DOI: 10.1021/ja017885e  1
2002 Frank SA, Roush WR. Studies on the synthesis of (-)-spinosyn a: application of the steric directing group strategy to transannular Diels-Alder reactions. The Journal of Organic Chemistry. 67: 4316-24. PMID 12054969 DOI: 10.1021/jo025580s  1
2002 Roush WR, Bannister TD, Wendt MD, VanNieuwenhze MS, Gustin DJ, Dilley GJ, Lane GC, Scheidt KA, Smith WJ. An NMR method for assigning relative stereochemistry to beta-hydroxy ketones deriving from aldol reactions of methyl ketones. The Journal of Organic Chemistry. 67: 4284-9. PMID 12054964 DOI: 10.1021/jo0164148  1
2002 Roush WR, Bannister TD, Wendt MD, Jablonowski JA, Scheidt KA. Studies on the synthesis of bafilomycin A(1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C25) segment. The Journal of Organic Chemistry. 67: 4275-83. PMID 12054963 DOI: 10.1021/jo016413f  1
2002 Roush WR, Limberakis C, Kunz RK, Barda DA. Diastereoselective synthesis of the endo- and exo-spirotetronate subunits of the quartromicins. The first enantioselective Diels-Alder reaction of an acyclic (Z)-1,3-diene. Organic Letters. 4: 1543-6. PMID 11975624  0.84
2002 Roush WR, Barda DA. Partial stereochemical assignment of quartromicins A3 and D3. Organic Letters. 4: 1539-42. PMID 11975623 DOI: 10.1021/ol025771h  1
2002 Frank SA, Mergott DJ, Roush WR. The vinylogous intramolecular Morita-Baylis-Hillman reaction: synthesis of functionalized cyclopentenes and cyclohexenes with trialkylphosphines as nucleophilic catalysts. Journal of the American Chemical Society. 124: 2404-5. PMID 11890766 DOI: 10.1021/ja017123j  1
2002 Holson EB, Roush WR. Diastereoselective synthesis of the C(17)-C(28) fragment (the C-D spiroketal unit) of spongistatin 1 (altohyrtin A) via a kinetically controlled lodo-spiroketalization reaction Organic Letters. 4: 3719-3722. DOI: 10.1021/ol0266875  1
2002 Roush WR, Limberakis C, Kunz RK, Barda DA. Diastereoselective Synthesis of the endo- and exo-Spirotetronate Subunits of the Quartromicins. The First Enantioselective Diels - Alder Reaction of an Acyclic (Z)-1,3-Diene Organic Letters. 4: 1543-1546. DOI: 10.1021/ol025772+  1
2002 Roush WR, Hertel L, Schnaderbeck MJ, Yakelis NA. Synthesis of the C(18)-C(26) segment of superstolide A Tetrahedron Letters. 43: 4885-4887. DOI: 10.1016/S0040-4039(02)00903-6  1
2002 Roush WR, Barda DA, Limberakis C, Kunz RK. Studies on the synthesis of the quartromicins: Partial stereochemical assignment of quartromicins A3 and D3 and diastereoselective synthesis of the endo- and exo-spirotetronate subunits Tetrahedron. 58: 6433-6454. DOI: 10.1016/S0040-4020(02)00656-7  1
2002 Abiko A, Simons LJ, Roush WR. 2-(N-benzyl-n-mesitylenesulfonyl)amino-1-phenyl-1-propyl propionate Organic Syntheses. 79: 109-114.  1
2002 Abiko A, Flamme EM, Roush WR. Anti-selective boron-mediated asymmetric aldol reaction of carboxylic esters: Synthesis of (2S, 3R)-2,4-dimethyl-1,3-pentanediol Organic Syntheses. 79: 116-123.  1
2002 Johns BA, Grant CM, Marshall JA, Holson EB, Roush WR. Synthesis and utilization of indium (i) iodide for in situ formation of enantioenriched allenylindium reagents and their addition to aldehydes: (2r,3s,4s)-1-(tertbutyldiphenylsilyloxy)-2,4-dimethyl-5-hexyn-3-ol Organic Syntheses. 79: 59-70.  1
2002 Abiko A, Flamme EM, Roush WR. Dicyclohexylboron trifluoromethanesulfonate Organic Syntheses. 79: 103-107.  1
2002 Roush WR, Chen H, Reilly ML. Studies on the synthesis of kijanolide: Synthesis of an advanced seco-acid intermediate Heterocycles. 58: 259-282.  1
2002 Roush WR, James RA. Towards the synthesis of aureolic acid analogue conjugates: Synthesis and glycosidation reactions of 3-o-acetyl-4-azido-2,4,6-trideoxy-L-glucopyranose derivatives Australian Journal of Chemistry. 55: 141-146.  1
2002 Roush WR, Powell NA, James RA. Synthesis of structurally simplified aureolic acid aglycone-C-D-E trisaccharide analogues Australian Journal of Chemistry. 55: 113-121.  1
2001 Caffrey CR, Hansell E, Lucas KD, Brinen LS, Alvarez Hernandez A, Cheng J, Gwaltney SL, Roush WR, Stierhof YD, Bogyo M, Steverding D, McKerrow JH. Active site mapping, biochemical properties and subcellular localization of rhodesain, the major cysteine protease of Trypanosoma brucei rhodesiense. Molecular and Biochemical Parasitology. 118: 61-73. PMID 11704274 DOI: 10.1016/S0166-6851(01)00368-1  1
2001 Roush WR, Cheng J, Knapp-Reed B, Alvarez-Hernandez A, McKerrow JH, Hansell E, Engel JC. Potent second generation vinyl sulfonamide inhibitors of the trypanosomal cysteine protease cruzain. Bioorganic & Medicinal Chemistry Letters. 11: 2759-62. PMID 11591518 DOI: 10.1016/S0960-894X(01)00566-2  1
2001 Roush WR, Bennett CE, Roberts SE. Studies on the synthesis of landomycin A: synthesis and glycosidation reactions of L-rhodinosyl acetate derivatives. The Journal of Organic Chemistry. 66: 6389-93. PMID 11559191 DOI: 10.1021/jo015756a  1
2001 Savall BM, Powell NA, Roush WR. Highly diastereoselective synthesis of propargylic 1,2-anti-diol derivatives using alpha-alkoxypropargylstannanes. Organic Letters. 3: 3057-60. PMID 11554842 DOI: 10.1021/ol016536m  1
2001 Ménard R, Therrien C, Lachance P, Sulea T, Qo H, Alvarez-Hernandez AD, Roush WR. Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design. Biological Chemistry. 382: 839-45. PMID 11517939 DOI: 10.1515/BC.2001.102  1
2001 Powell NA, Roush WR. Studies on the total synthesis of formamicin: synthesis of the C(1)-C(11) fragment. Organic Letters. 3: 453-6. PMID 11428037 DOI: 10.1021/ol0069610  1
2001 Micalizio GC, Roush WR. Studies on the synthesis of pectenotoxin II: synthesis of a C(11)-C(26) fragment precursor via [3 + 2]-annulation reactions of chiral allylsilanes. Organic Letters. 3: 1949-52. PMID 11405752 DOI: 10.1021/ol0160250  1
2001 Yakelis NA, Roush WR. Lewis acid catalyzed intramolecular Diels-Alder reactions of acyclic (Z)-substituted 1,3-dienes. Organic Letters. 3: 957-60. PMID 11263925 DOI: 10.1021/ol015667k  1
2001 Therrien C, Lachance P, Sulea T, Purisima EO, Qi H, Ziomek E, Alvarez-Hernandez A, Roush WR, Ménard R. Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities. Biochemistry. 40: 2702-11. PMID 11258881 DOI: 10.1021/bi002460a  1
2001 Roush WR, Madar DJ, Coffey DS. Synthesis of highly functionalized naphthoate precursors to damavaricin D - Observation of kinetically stable benzocyclohexadienones in the bromination reactions of highly functionalized β-naphthol derivatives Canadian Journal of Chemistry. 79: 1711-1726. DOI: 10.1139/cjc-79-11-1711  1
2001 Roush WR, Dilley GJ. Studies on the synthesis of 2,6-disubstituted dihydropyrans: Intervention of oxonia-cope rearrangements in the lewis acid mediated cyclodehydrative reactions of aldehydes and β-hydroxyallylsilanes Synlett. 955-959.  1
2000 Micalizio GC, Pinchuk AN, Roush WR. Synthesis of the C(29)-C(45) bis-pyran subunit (E-F) of spongistatin 1 (Altohyrtin A). The Journal of Organic Chemistry. 65: 8730-6. PMID 11112596 DOI: 10.1021/jo001236o  1
2000 Brinen LS, Hansell E, Cheng J, Roush WR, McKerrow JH, Fletterick RJ. A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease. Structure (London, England : 1993). 8: 831-40. PMID 10997902 DOI: 10.1016/S0969-2126(00)00173-8  1
2000 Frank SA, Chen H, Kunz RK, Schnaderbeck MJ, Roush WR. Use of thallium(I) ethoxide in Suzuki cross coupling reactions. Organic Letters. 2: 2691-4. PMID 10990429  1
2000 Micalizio GC, Roush WR. A three-component coupling strategy for tetrahydrofuran synthesis: application of the diisopropyl tartrate modified (E)-gamma-(dimethylphenylsilyl)allylboronate as an alpha,gamma-allyl dianion equivalent. Organic Letters. 2: 461-4. PMID 10814351  1
2000 Roush WR, Pfeifer LA. Total synthesis of mycalamide A and 7-epi-mycalamide A. Organic Letters. 2: 859-62. PMID 10754688  1
2000 Roush WR, Bennett CE. A highly stereoselective synthesis of the landomycin a hexasaccharide unit [10] Journal of the American Chemical Society. 122: 6124-6125. DOI: 10.1021/ja000743k  1
2000 Roush WR, Hernandez AA, McKerrow JH, Selzer PM, Hansell E, Engel JC. Design, synthesis and evaluation of D-Homophenylalanyl epoxysuccinate inhibitors of the trypanosomal cysteine protease cruzain Tetrahedron. 56: 9747-9762.  1
2000 Roush WR, Pinchuk AN, Micalizio GC. [(E)-γ-(Dimethylphenylsilyl)allyl]diisopinocampheylborane: A highly enantioselective reagent for the synthesis of anti-β-hydroxyallylsilanes Tetrahedron Letters. 41: 9413-9417.  1
2000 Frank SA, Works AB, Roush WR. Studies on the synthesis of the decahydro-as-indacene ring system of (-)-spinosyn A via transannular Diels-Alder reactions of substituted (E,E,E)-cyclododeca-1,6,8-trienes Canadian Journal of Chemistry. 78: 757-771.  1
2000 Micalizio GC, Roush WR. A three-component coupling strategy for tetrahydrofuran synthesis: Application of the diisopropyl tartrate modified (E)-γ-(dimethylphenylsilyl)allylboronate as an α,γ-allyl dianion equivalent Organic Letters. 2: 461-464.  1
1999 Scheidt KA, Tasaka A, Bannister TD, Wendt MD, Roush WR. Total Synthesis of (-)-Bafilomycin A : Application of Diastereoselective Crotylboration and Methyl Ketone Aldol Reactions. Angewandte Chemie (International Ed. in English). 38: 1652-1655. PMID 29710989 DOI: 10.1002/(SICI)1521-3773(19990601)38:11<1652::AID-ANIE1652>3.0.CO;2-K  0.64
1999 Roush WR, Narayan S. 2-Deoxy-2-iodo-alpha-mannopyranosyl and -talopyranosyl acetates: highly stereoselective glycosyl donors for the synthesis of 2-deoxy-alpha-glycosides. Organic Letters. 1: 899-902. PMID 10823220  1
1999 Roush WR, Narayan S, Bennett CE, Briner K. Iodoacetoxylation of glycals using cerium(IV) ammonium nitrate, sodium iodide, and acetic acid: stereoselective synthesis of 2-deoxy-2-iodo-alpha-mannopyranosyl acetates. Organic Letters. 1: 895-7. PMID 10823219  1
1999 Roush WR, Gung BW, Bennett CE. 2-Deoxy-2-iodo- and 2-deoxy-2-bromo-alpha-glucopyranosyl trichloroacetimidates: highly reactive and stereoselective donors for the synthesis of 2-deoxy-beta-glycosides. Organic Letters. 1: 891-3. PMID 10823218  1
1999 Roush WR, Lane GC. Studies on the synthesis of tedanolide: synthesis of the C(5)-C(21) segment via a highly stereoselective fragment assembly aldol reaction of a chiral beta,gamma-unsaturated methyl ketone. Organic Letters. 1: 95-8. PMID 10822542  1
1999 Roush WR, Bennett CE. A highly stereoselective synthesis of 2-deoxy-β-glycosides using 2- deoxy-2-iodo-glucopyranosyl acetate donors [7] Journal of the American Chemical Society. 121: 3541-3542. DOI: 10.1021/ja984365j  1
1999 Roush WR, Hartz RA, Gustin DJ. Total synthesis of olivomycin A [19] Journal of the American Chemical Society. 121: 1990-1991. DOI: 10.1021/ja984229e  1
1999 Roush WR, Dilley GJ. Studies of fragment assembly aldol reactions of chiral aldehydes and chiral methyl ketones: Stereoselective synthesis of the C(13)-C(25) segment of scytophycin C Tetrahedron Letters. 40: 4955-4959. DOI: 10.1016/S0040-4039(99)00868-0  1
1999 Chemler SR, Roush WR. Stereochemically divergent pathways for the allylation and crotylation reactions of anti- and syn-β-hydroxy-α-methyl aldehydes with allyl- and crotyltrifluorosilanes Tetrahedron Letters. 40: 4643-4647. DOI: 10.1016/S0040-4039(99)00730-3  1
1999 Micalizio GC, Roush WR. Towards the synthesis of spongistatin 1: Diastereoselective synthesis of the C(36)-C(45) subunit Tetrahedron Letters. 40: 3351-3354. DOI: 10.1016/S0040-4039(99)00464-5  1
1999 Chemler SR, Coffey DS, Roush WR. An improved synthesis of the (E,Z)-dienoate precursor of (+)-damavaricin D via a vinylogous Horner-Wadsworth-Emmons reaction Tetrahedron Letters. 40: 1269-1272. DOI: 10.1016/S0040-4039(98)02638-0  1
1999 Scheldt KA, Tasaka A, Bannister TD, Wendt MD, Roush WR. Total synthesis of (-)-bafilomycin A1: Application of diastereoselective crotylboration and methyl ketone aldol reactions Angewandte Chemie - International Edition. 38: 1652-1655. DOI: 10.1002/(SICI)1521-3773(19990601)38:11<1652::AID-ANIE1652>3.0.CO;2-K  1
1999 Roush WR, Hernandez AA, Zepeda G. A new synthesis of peptidyl epoxysuccinates for probing cysteine protease-inhibitor P3/S3 binding interactions Synthesis. 1500-1504.  1
1998 Scheidt KA, Roush WR, McKerrow JH, Selzer PM, Hansell E, Rosenthal PJ. Structure-based design, synthesis and evaluation of conformationally constrained cysteine protease inhibitors. Bioorganic & Medicinal Chemistry. 6: 2477-94. PMID 9925304 DOI: 10.1016/S0968-0896(98)80022-9  1
1998 Roush WR, González FV, McKerrow JH, Hansell E. Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain. Bioorganic & Medicinal Chemistry Letters. 8: 2809-12. PMID 9873627  0.48
1997 Roush WR, Marron TG, Pfeifer LA. Highly Diastereoselective Synthesis of Pederic Acid Derivatives. The Journal of Organic Chemistry. 62: 474-478. PMID 11671436 DOI: 10.1021/jo961841k  1
1996 Roush WR, Briner K, Kesler BS, Murphy M, Gustin DJ. Studies on the Synthesis of Aureolic Acid Antibiotics: Acyloin Glycosidation Studies. The Journal of Organic Chemistry. 61: 6098-6099. PMID 11667440  0.72
1994 Li Z, Chen X, Davidson E, Zwang O, Mendis C, Ring CS, Roush WR, Fegley G, Li R, Rosenthal PJ, Lee GK, Kenyon GL, Kuntz ID, Cohen FE. Anti-malarial drug development using models of enzyme structure Chemistry and Biology. 1: 31-37. PMID 9383368 DOI: 10.1016/1074-5521(94)90038-8  1
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