H.Th. Marc Timmers - Publications

Utrecht University, Utrecht, Netherlands 
expression of the human genome

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Timmers HTM. SAGA and TFIID: Friends of TBP drifting apart. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. 194604. PMID 32673655 DOI: 10.1016/J.Bbagrm.2020.194604  0.471
2019 Bhuiyan T, Timmers HTM. Promoter Recognition: Putting TFIID on the Spot. Trends in Cell Biology. PMID 31300188 DOI: 10.1016/J.Tcb.2019.06.004  0.486
2018 Timmers HTM, Tora L. Transcript Buffering: A Balancing Act between mRNA Synthesis and mRNA Degradation. Molecular Cell. 72: 10-17. PMID 30290147 DOI: 10.1016/J.Molcel.2018.08.023  0.371
2018 Conemans EB, Lodewijk L, Moelans CM, Offerhaus GJA, Pieterman CRC, Morsink FH, Dekkers OM, de Herder WW, Hermus AR, van der Horst-Schrivers ANA, Drent ML, Bisschop PH, Havekes B, Brosens LAA, Dreijerink KMA, ... ... Timmers HTM, et al. DNA methylation profiling in MEN1-related pancreatic neuroendocrine tumors reveals a potential epigenetic target for treatment. European Journal of Endocrinology. PMID 29903750 DOI: 10.1530/Eje-18-0195  0.305
2016 Baas R, Sijm A, van Teeffelen HA, van Es R, Vos HR, Timmers HT. Quantitative Proteomics of the SMAD (Suppressor of Mothers Against Decapentaplegic) Transcription Factor Family Identifies Importin 5 as a Bone Morphogenic Protein Receptor-SMAD specific Importin. The Journal of Biological Chemistry. PMID 27703004 DOI: 10.1074/Jbc.M116.748582  0.405
2015 Koster MJ, Snel B, Timmers HT. Genesis of Chromatin and Transcription Dynamics in the Origin of Species. Cell. 161: 724-736. PMID 25957681 DOI: 10.1016/J.Cell.2015.04.033  0.463
2015 Koster MJ, Timmers HT. Regulation of anti-sense transcription by Mot1p and NC2 via removal of TATA-binding protein (TBP) from the 3'-end of genes. Nucleic Acids Research. 43: 143-52. PMID 25432956 DOI: 10.1093/Nar/Gku1263  0.459
2015 Koster MJE, Timmers HTM. Regulation of anti-sense transcription by Mot1p and NC2 via removal of TATA-binding protein (TBP) from the 3'-end of genes Nucleic Acids Research. 43: 143-152. DOI: 10.1093/nar/gku1263  0.327
2014 Koster MJE, Yildirim AD, Weil PA, Holstege FCP, Timmers HTM. Suppression of intragenic transcription requires the MOT1 and NC2 regulators of TATA-binding protein Nucleic Acids Research. 42: 4220-4229. PMID 24459134 DOI: 10.1093/nar/gkt1398  0.38
2014 Pieterman CRC, Conemans EB, Dreijerink KMA, De Laat JM, Timmers HTM, Vriens MR, Valk GD. Thoracic and duodenopancreatic neuroendocrine tumors in multiple endocrine neoplasia type 1: Natural history and function of menin in tumorigenesis Endocrine-Related Cancer. 21: R121-R142. PMID 24389729 DOI: 10.1530/Erc-13-0482  0.301
2014 Baas R, Lelieveld D, Van Teeffelen H, Lijnzaad P, Castelijns B, Van Schaik FM, Vermeulen M, Egan DA, Timmers HTM, De Graaf P. A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels Journal of Biomolecular Screening. 19: 287-296. PMID 24334265 DOI: 10.1177/1087057113515024  0.38
2013 Schram AW, Baas R, Jansen PWTC, Riss A, Tora L, Vermeulen M, Timmers HTM. A Dual Role for SAGA-Associated Factor 29 (SGF29) in ER Stress Survival by Coordination of Both Histone H3 Acetylation and Histone H3 Lysine-4 Trimethylation Plos One. 8. PMID 23894581 DOI: 10.1371/Journal.Pone.0070035  0.382
2013 van Nuland R, Smits AH, Pallaki P, Jansen PW, Vermeulen M, Timmers HT. Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes. Molecular and Cellular Biology. 33: 2067-77. PMID 23508102 DOI: 10.1128/MCB.01742-12  0.308
2013 Pijnappel WW, Esch D, Baltissen MP, Wu G, Mischerikow N, Bergsma AJ, van der Wal E, Han DW, Bruch Hv, Moritz S, Lijnzaad P, Altelaar AF, Sameith K, Zaehres H, Heck AJ, ... ... Timmers HT, et al. A central role for TFIID in the pluripotent transcription circuitry. Nature. 495: 516-9. PMID 23503660 DOI: 10.1038/Nature11970  0.333
2012 van Wijk SJ, Melquiond AS, de Vries SJ, Timmers HT, Bonvin AM. Dynamic control of selectivity in the ubiquitination pathway revealed by an ASP to GLU substitution in an intra-molecular salt-bridge network. Plos Computational Biology. 8: e1002754. PMID 23133359 DOI: 10.1371/Journal.Pcbi.1002754  0.317
2012 Kleinschmidt MA, de Graaf P, van Teeffelen HAAM, Timmers HTM. Cell cycle regulation by the PRMT6 arginine methyltransferase through repression of cyclin-dependent kinase inhibitors Plos One. 7. PMID 22916108 DOI: 10.1371/Journal.Pone.0041446  0.344
2012 Choukrallah MA, Kobi D, Martianov I, Pijnappel WW, Mischerikow N, Ye T, Heck AJ, Timmers HT, Davidson I. Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome. Nucleic Acids Research. 40: 1446-59. PMID 22013162 DOI: 10.1093/Nar/Gkr802  0.43
2012 Spedale G, Meddens CA, Koster MJE, Ko CW, Van Hooff SR, Holstege FCP, Timmers HTM, Pijnappel WWMP. Tight cooperation between Mot1p and NC2β in regulating genome-wide transcription, repression of transcription following heat shock induction and genetic interaction with SAGA Nucleic Acids Research. 40: 996-1008. PMID 21976730 DOI: 10.1093/Nar/Gkr784  0.482
2011 Sandler H, Kreth J, Timmers HTM, Stoecklin G. Not1 mediates recruitment of the deadenylase Caf1 to mRNAs targeted for degradation by tristetraprolin Nucleic Acids Research. 39: 4373-4386. PMID 21278420 DOI: 10.1093/Nar/Gkr011  0.458
2010 Varier RA, Outchkourov NS, de Graaf P, van Schaik FM, Ensing HJ, Wang F, Higgins JM, Kops GJ, Timmers HT. A phospho/methyl switch at histone H3 regulates TFIID association with mitotic chromosomes. The Embo Journal. 29: 3967-78. PMID 20953165 DOI: 10.1038/Emboj.2010.261  0.329
2010 Bonnet J, Wang YH, Spedale G, Atkinson RA, Romier C, Hamiche A, Pijnappel WW, Timmers HT, Tora L, Devys D, Kieffer B. The structural plasticity of SCA7 domains defines their differential nucleosome-binding properties. Embo Reports. 11: 612-8. PMID 20634802 DOI: 10.1038/Embor.2010.98  0.353
2010 de Graaf P, Mousson F, Geverts B, Scheer E, Tora L, Houtsmuller AB, Timmers HT. Chromatin interaction of TATA-binding protein is dynamically regulated in human cells. Journal of Cell Science. 123: 2663-71. PMID 20627952 DOI: 10.1242/Jcs.064097  0.478
2010 Hah N, Kolkman A, Ruhl DD, Pijnappel WW, Heck AJ, Timmers HT, Kraus WL. A role for BAF57 in cell cycle-dependent transcriptional regulation by the SWI/SNF chromatin remodeling complex. Cancer Research. 70: 4402-11. PMID 20460533 DOI: 10.1158/0008-5472.Can-09-2767  0.401
2010 Tora L, Timmers HT. The TATA box regulates TATA-binding protein (TBP) dynamics in vivo. Trends in Biochemical Sciences. 35: 309-14. PMID 20176488 DOI: 10.1016/J.Tibs.2010.01.007  0.462
2010 Timmers HT, Tora L. The spectacular landscape of chromatin and ncRNAs under the Tico sunlight. Embo Reports. 11: 147-9. PMID 20154643 DOI: 10.1038/Embor.2010.26  0.367
2009 Pijnappel WP, Kolkman A, Baltissen MP, Heck AJ, Timmers HM. Quantitative mass spectrometry of TATA binding protein-containing complexes and subunit phosphorylations during the cell cycle. Proteome Science. 7: 46. PMID 20034391 DOI: 10.1186/1477-5956-7-46  0.362
2009 van Werven FJ, van Teeffelen HA, Holstege FC, Timmers HT. Distinct promoter dynamics of the basal transcription factor TBP across the yeast genome. Nature Structural & Molecular Biology. 16: 1043-8. PMID 19767748 DOI: 10.1038/Nsmb.1674  0.439
2009 Mischerikow N, Spedale G, Altelaar AF, Timmers HT, Pijnappel WW, Heck AJ. In-depth profiling of post-translational modifications on the related transcription factor complexes TFIID and SAGA. Journal of Proteome Research. 8: 5020-30. PMID 19731963 DOI: 10.1021/Pr900449E  0.41
2009 Dreijerink KM, Varier RA, van Nuland R, Broekhuizen R, Valk GD, van der Wal JE, Lips CJ, Kummer JA, Timmers HT. Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas. Molecular and Cellular Endocrinology. 313: 1-8. PMID 19729047 DOI: 10.1016/J.Mce.2009.08.020  0.363
2009 van Wijk SJ, de Vries SJ, Kemmeren P, Huang A, Boelens R, Bonvin AM, Timmers HT. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. Molecular Systems Biology. 5: 295. PMID 19690564 DOI: 10.1038/Msb.2009.55  0.306
2009 Lau NC, Kolkman A, van Schaik FM, Mulder KW, Pijnappel WW, Heck AJ, Timmers HT. Human Ccr4-Not complexes contain variable deadenylase subunits. The Biochemical Journal. 422: 443-53. PMID 19558367 DOI: 10.1042/Bj20090500  0.38
2009 Dreijerink KMA, Lips CJM, Timmers HTM. Multiple endocrine neoplasia type 1: A chromatin writer's block Journal of Internal Medicine. 266: 53-59. PMID 19522825 DOI: 10.1111/j.1365-2796.2009.02115.x  0.314
2008 van Werven FJ, van Bakel H, van Teeffelen HA, Altelaar AF, Koerkamp MG, Heck AJ, Holstege FC, Timmers HT. Cooperative action of NC2 and Mot1p to regulate TATA-binding protein function across the genome. Genes & Development. 22: 2359-69. PMID 18703679 DOI: 10.1101/Gad.1682308  0.482
2008 van Ingen H, van Schaik FM, Wienk H, Ballering J, Rehmann H, Dechesne AC, Kruijzer JA, Liskamp RM, Timmers HT, Boelens R. Structural insight into the recognition of the H3K4me3 mark by the TFIID subunit TAF3. Structure (London, England : 1993). 16: 1245-56. PMID 18682226 DOI: 10.1016/J.Str.2008.04.015  0.446
2008 Mousson F, Kolkman A, Pijnappel WW, Timmers HT, Heck AJ. Quantitative proteomics reveals regulation of dynamic components within TATA-binding protein (TBP) transcription complexes. Molecular & Cellular Proteomics : McP. 7: 845-52. PMID 18087068 DOI: 10.1074/Mcp.M700306-Mcp200  0.417
2007 Vermeulen M, Mulder KW, Denissov S, Pijnappel WW, van Schaik FM, Varier RA, Baltissen MP, Stunnenberg HG, Mann M, Timmers HT. Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4. Cell. 131: 58-69. PMID 17884155 DOI: 10.1016/J.Cell.2007.08.016  0.461
2007 Mulder KW, Inagaki A, Cameroni E, Mousson F, Winkler GS, De Virgilio C, Collart MA, Timmers HT. Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae. Genetics. 176: 181-92. PMID 17513889 DOI: 10.1534/Genetics.106.060640  0.411
2007 Mulder KW, Brenkman AB, Inagaki A, van den Broek NJ, Timmers HT. Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex. Nucleic Acids Research. 35: 2428-39. PMID 17392337 DOI: 10.1093/Nar/Gkm175  0.45
2006 Dreijerink KMA, Höppener JWM, Timmers HTM, Lips CJM. Mechanisms of Disease: Multiple endocrine neoplasia type 1 - Relation to chromatin modifications and transcription regulation Nature Clinical Practice Endocrinology and Metabolism. 2: 562-570. PMID 17024155 DOI: 10.1038/ncpendmet0292  0.336
2006 Winkler GS, Mulder KW, Bardwell VJ, Kalkhoven E, Timmers HT. Human Ccr4-Not complex is a ligand-dependent repressor of nuclear receptor-mediated transcription. The Embo Journal. 25: 3089-99. PMID 16778766 DOI: 10.1038/Sj.Emboj.7601194  0.451
2006 Jayne S, Zwartjes CG, van Schaik FM, Timmers HT. Involvement of the SMRT/NCoR-HDAC3 complex in transcriptional repression by the CNOT2 subunit of the human Ccr4-Not complex. The Biochemical Journal. 398: 461-7. PMID 16712523 DOI: 10.1042/Bj20060406  0.471
2006 Dreijerink KM, Mulder KW, Winkler GS, Höppener JW, Lips CJ, Timmers HT. Menin links estrogen receptor activation to histone H3K4 trimethylation. Cancer Research. 66: 4929-35. PMID 16651450 DOI: 10.1158/0008-5472.Can-05-4461  0.423
2006 van Werven FJ, Timmers HT. The use of biotin tagging in Saccharomyces cerevisiae improves the sensitivity of chromatin immunoprecipitation. Nucleic Acids Research. 34: e33. PMID 16500888 DOI: 10.1093/Nar/Gkl003  0.461
2006 van Oevelen CJ, van Teeffelen HA, van Werven FJ, Timmers HT. Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters. The Journal of Biological Chemistry. 281: 4523-31. PMID 16368692 DOI: 10.1074/Jbc.M509330200  0.421
2005 Mulder KW, Winkler GS, Timmers HT. DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex. Nucleic Acids Research. 33: 6384-92. PMID 16275785 DOI: 10.1093/Nar/Gki938  0.452
2005 Klejman MP, Zhao X, van Schaik FM, Herr W, Timmers HT. Mutational analysis of BTAF1-TBP interaction: BTAF1 can rescue DNA-binding defective TBP mutants. Nucleic Acids Research. 33: 5426-36. PMID 16179647 DOI: 10.1093/Nar/Gki850  0.417
2004 Dominguez C, Bonvin AM, Winkler GS, van Schaik FM, Timmers HT, Boelens R. Structural model of the UbcH5B/CNOT4 complex revealed by combining NMR, mutagenesis, and docking approaches. Structure (London, England : 1993). 12: 633-44. PMID 15062086 DOI: 10.1016/J.Str.2004.03.004  0.348
2004 Winkler GS, Albert TK, Dominguez C, Legtenberg YI, Boelens R, Timmers HT. An altered-specificity ubiquitin-conjugating enzyme/ubiquitin-protein ligase pair. Journal of Molecular Biology. 337: 157-65. PMID 15001359 DOI: 10.1016/J.Jmb.2004.01.031  0.375
2004 Pereira LA, Klejman MP, Ruhlmann C, Kavelaars F, Oulad-Abdelghani M, Timmers HT, Schultz P. Molecular architecture of the basal transcription factor B-TFIID. The Journal of Biological Chemistry. 279: 21802-7. PMID 14988402 DOI: 10.1074/Jbc.M313519200  0.37
2003 Pereira LA, Klejman MP, Timmers HT. Roles for BTAF1 and Mot1p in dynamics of TATA-binding protein and regulation of RNA polymerase II transcription. Gene. 315: 1-13. PMID 14557059 DOI: 10.1016/S0378-1119(03)00714-5  0.46
2002 Andrau JC, Van Oevelen CJ, Van Teeffelen HA, Weil PA, Holstege FC, Timmers HT. Mot1p is essential for TBP recruitment to selected promoters during in vivo gene activation. The Embo Journal. 21: 5173-83. PMID 12356733 DOI: 10.1093/Emboj/Cdf485  0.44
2002 Timmers HT. Linking activators and basals in transcription: it is all in one family. Molecular Cell. 9: 697-8. PMID 11983160 DOI: 10.1016/S1097-2765(02)00511-7  0.412
2002 Albert TK, Hanzawa H, Legtenberg YI, de Ruwe MJ, van den Heuvel FA, Collart MA, Boelens R, Timmers HT. Identification of a ubiquitin-protein ligase subunit within the CCR4-NOT transcription repressor complex. The Embo Journal. 21: 355-64. PMID 11823428 DOI: 10.1093/Emboj/21.3.355  0.437
2001 Mittler G, Kremmer E, Timmers HTM, Meisterernst M. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription Embo Reports. 2: 808-813. PMID 11559591 DOI: 10.1093/Embo-Reports/Kve186  0.442
2001 Fiedler U, Timmers HTM. Analysis of the open region of RNA polymerase II transcription complexes in the early phase of elongation Nucleic Acids Research. 29: 2706-2714. PMID 11433015 DOI: 10.1093/Nar/29.13.2706  0.424
2000 Fiedler U, Timmers HTM. Peeling by binding or twisting by cranking: Models for promoter opening and transcription initiation by RNA polymerase II Bioessays. 22: 316-326. PMID 10723029 DOI: 10.1002/(Sici)1521-1878(200004)22:4<316::Aid-Bies2>3.0.Co;2-B  0.427
2000 Albert TK, Lemaire M, Berkum NLv, Gentz R, Collart MA, Timmers HTM. Isolation and characterization of human orthologs of yeast CCR4–NOT complex subunits Nucleic Acids Research. 28: 809-817. PMID 10637334 DOI: 10.1093/Nar/28.3.809  0.4
2000 Knaap JAVD, Boom VVD, Kuipers J, Eijk MJTV, Vliet PCVD, Timmers HTM. The gene for human TATA-binding-protein-associated factor (TAFII) 170: structure, promoter and chromosomal localization. Biochemical Journal. 345: 521-527. DOI: 10.1042/Bj3450521  0.398
1998 Walhout AJ, van der Vliet PC, Timmers HT. Sequences flanking the E-box contribute to cooperative binding by c-Myc/Max heterodimers to adjacent binding sites. Biochimica Et Biophysica Acta. 1397: 189-201. PMID 9565685 DOI: 10.1016/S0167-4781(97)00227-3  0.315
1998 Werten S, Langen FW, van Schaik R, Timmers HT, Meisterernst M, van der Vliet PC. High-affinity DNA binding by the C-terminal domain of the transcriptional coactivator PC4 requires simultaneous interaction with two opposing unpaired strands and results in helix destabilization. Journal of Molecular Biology. 276: 367-77. PMID 9512709 DOI: 10.1006/Jmbi.1997.1534  0.399
1997 Holstege FCP, Fiedler U, Timmers HTM. Three transitions in the RNA polymerase II transcription complex during initiation The Embo Journal. 16: 7468-7480. PMID 9405375 DOI: 10.1093/Emboj/16.24.7468  0.411
1997 van der Knaap JA, Borst JW, van der Vliet PC, Gentz R, Timmers HT. Cloning of the cDNA for the TATA-binding protein-associated factorII170 subunit of transcription factor B-TFIID reveals homology to global transcription regulators in yeast and Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 94: 11827-32. PMID 9342322 DOI: 10.1073/Pnas.94.22.11827  0.463
1997 Holstege FCP, Timmers HTM. Analysis of open complex formation during RNA polymerase II transcription initiation using heteroduplex templates and potassium permanganate probing. Methods. 12: 203-211. PMID 9237164 DOI: 10.1006/Meth.1997.0472  0.431
1990 Timmers HTM, Pronk GJ, Bos JL, Van Der Eb AJ. Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction Nucleic Acids Research. 18: 23-34. PMID 2106664 DOI: 10.1093/Nar/18.1.23  0.555
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