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Morris F. White - Publications

Harvard University, Cambridge, MA, United States 
Biochemistry, Pathology

191 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Lavin DP, White MF, Brazil DP. IRS proteins and diabetic complications. Diabetologia. PMID 27514532 DOI: 10.1007/s00125-016-4072-7  1
2016 Metz HE, Kargl J, Busch SE, Kim KH, Kurland BF, Abberbock SR, Randolph-Habecker J, Knoblaugh SE, Kolls JK, White MF, Houghton AM. Insulin receptor substrate-1 deficiency drives a proinflammatory phenotype in KRAS mutant lung adenocarcinoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 27439864 DOI: 10.1073/Pnas.1601989113  1
2016 Copps KD, Hançer NJ, Qiu W, White MF. Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (Irs1) Is Dispensable For Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase. The Journal of Biological Chemistry. PMID 26846849 DOI: 10.1074/jbc.M116.714915  1
2014 White MF. IRS2 integrates insulin/IGF1 signalling with metabolism, neurodegeneration and longevity Diabetes, Obesity and Metabolism. 16: 4-15. PMID 25200290 DOI: 10.1111/dom.12347  1
2014 Riehle C, Wende AR, Zhu Y, Oliveira KJ, Pereira RO, Jaishy BP, Bevins J, Valdez S, Noh J, Kim BJ, Moreira AB, Weatherford ET, Manivel R, Rawlings TA, Rech M, ... White MF, et al. Insulin receptor substrates are essential for the bioenergetic and hypertrophic response of the heart to exercise training. Molecular and Cellular Biology. 34: 3450-60. PMID 25002528 DOI: 10.1128/MCB.00426-14  1
2014 Ryu J, Galan AK, Xin X, Dong F, Abdul-Ghani MA, Zhou L, Wang C, Li C, Holmes BM, Sloane LB, Austad SN, Guo S, Musi N, DeFronzo RA, Deng C, ... White MF, et al. APPL1 potentiates insulin sensitivity by facilitating the binding of IRS1/2 to the insulin receptor. Cell Reports. 7: 1227-38. PMID 24813896 DOI: 10.1016/j.celrep.2014.04.006  1
2014 Hançer NJ, Qiu W, Cherella C, Li Y, Copps KD, White MF. Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation. The Journal of Biological Chemistry. 289: 12467-84. PMID 24652289 DOI: 10.1074/jbc.M114.554162  1
2014 Sadagurski M, Dong XC, Myers MG, White MF. Irs2 and Irs4 synergize in non-LepRb neurons to control energy balance and glucose homeostasis. Molecular Metabolism. 3: 55-63. PMID 24567904 DOI: 10.1016/j.molmet.2013.10.004  1
2014 Herrema H, Lee J, Zhou Y, Copps KD, White MF, Ozcan U. IRS1Ser³⁰⁷ phosphorylation does not mediate mTORC1-induced insulin resistance. Biochemical and Biophysical Research Communications. 443: 689-93. PMID 24333417 DOI: 10.1016/j.bbrc.2013.12.023  1
2013 Riehle C, Wende AR, Sena S, Pires KM, Pereira RO, Zhu Y, Bugger H, Frank D, Bevins J, Chen D, Perry CN, Dong XC, Valdez S, Rech M, Sheng X, ... ... White MF, et al. Insulin receptor substrate signaling suppresses neonatal autophagy in the heart. The Journal of Clinical Investigation. 123: 5319-33. PMID 24177427 DOI: 10.1172/JCI71171  1
2013 Qi Y, Xu Z, Zhu Q, Thomas C, Kumar R, Feng H, Dostal DE, White MF, Baker KM, Guo S. Myocardial loss of IRS1 and IRS2 causes heart failure and is controlled by p38α MAPK during insulin resistance. Diabetes. 62: 3887-900. PMID 24159000 DOI: 10.2337/db13-0095  1
2013 Tao R, Xiong X, Harris RA, White MF, Dong XC. Genetic inactivation of pyruvate dehydrogenase kinases improves hepatic insulin resistance induced diabetes. Plos One. 8: e71997. PMID 23940800 DOI: 10.1371/Journal.Pone.0071997  1
2013 Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Science Signaling. 6: ra64. PMID 23901139 DOI: 10.1126/Scisignal.2004111  1
2013 Rhodes CJ, White MF, Leahy JL, Kahn SE. Direct autocrine action of insulin on β-cells: does it make physiological sense? Diabetes. 62: 2157-63. PMID 23801714 DOI: 10.2337/db13-0246  1
2013 Park K, Li Q, Rask-Madsen C, Mima A, Mizutani K, Winnay J, Maeda Y, D'Aquino K, White MF, Feener EP, King GL. Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells. Molecular and Cellular Biology. 33: 3227-41. PMID 23775122 DOI: 10.1128/MCB.00506-13  1
2013 Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR. Nerve growth factor receptor TrkA, a new receptor in insulin signaling pathway in PC12 cells. The Journal of Biological Chemistry. 288: 23807-13. PMID 23749991 DOI: 10.1074/jbc.M112.436279  1
2013 Hookham MB, O'Donovan HC, Church RH, Mercier-Zuber A, Luzi L, Curran SP, Carew RM, Droguett A, Mezzano S, Schubert M, White MF, Crean JK, Brazil DP. Insulin receptor substrate-2 is expressed in kidney epithelium and up-regulated in diabetic nephropathy. The Febs Journal. 280: 3232-43. PMID 23617393 DOI: 10.1111/febs.12305  1
2013 Jain S, De Azua IR, Lu H, White MF, Guettier JM, Wess J. Chronic activation of a designer Gq-coupled receptor improves β cell function Journal of Clinical Investigation. 123: 1750-1762. PMID 23478411 DOI: 10.1172/JCI66432  1
2013 Sadagurski M, White MF. Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinology and Metabolism Clinics of North America. 42: 127-48. PMID 23391244 DOI: 10.1016/j.ecl.2012.11.008  1
2013 Behl M, Rao D, Aagaard K, Davidson TL, Levin ED, Slotkin TA, Srinivasan S, Wallinga D, White MF, Walker VR, Thayer KA, Holloway AC. Evaluation of the association between maternal smoking, childhood obesity, and metabolic disorders: a national toxicology program workshop review. Environmental Health Perspectives. 121: 170-80. PMID 23232494 DOI: 10.1289/Ehp.1205404  1
2012 Copps KD, White MF. Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2 Diabetologia. 55: 2565-2582. PMID 22869320 DOI: 10.1007/s00125-012-2644-8  1
2012 Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan MP, Adam RM, White MF, Olumi AF. Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes. 61: 2134-45. PMID 22688336 DOI: 10.2337/db11-1763  1
2012 Matveyenko AV, Liuwantara D, Gurlo T, Kirakossian D, Dalla Man C, Cobelli C, White MF, Copps KD, Volpi E, Fujita S, Butler PC. Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes. 61: 2269-79. PMID 22688333 DOI: 10.2337/Db11-1462  1
2012 Sadagurski M, Leshan RL, Patterson C, Rozzo A, Kuznetsova A, Skorupski J, Jones JC, Depinho RA, Myers MG, White MF. IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action. Cell Metabolism. 15: 703-12. PMID 22560222 DOI: 10.1016/J.Cmet.2012.04.011  1
2012 Cheng Z, White MF. kNOXing on the door of selective insulin resistance. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 1063-5. PMID 22517360 DOI: 10.1161/ATVBAHA.112.246868  1
2012 Cheng Z, White MF. The AKTion in non-canonical insulin signaling. Nature Medicine. 18: 351-3. PMID 22395698 DOI: 10.1038/nm.2694  1
2012 Maeno Y, Li Q, Park K, Rask-Madsen C, Gao B, Matsumoto M, Liu Y, Wu IH, White MF, Feener EP, King GL. Inhibition of insulin signaling in endothelial cells by protein kinase C-induced phosphorylation of p85 subunit of phosphatidylinositol 3-kinase (PI3K) Journal of Biological Chemistry. 287: 4518-4530. PMID 22158866 DOI: 10.1074/jbc.M111.286591  1
2012 Martín ED, Sánchez-Perez A, Trejo JL, Martin-Aldana JA, Cano Jaimez M, Pons S, Acosta Umanzor C, Menes L, White MF, Burks DJ. IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation. Cerebral Cortex (New York, N.Y. : 1991). 22: 1717-27. PMID 21955917 DOI: 10.1093/cercor/bhr216  1
2011 Sadagurski M, Cheng Z, Rozzo A, Palazzolo I, Kelley GR, Dong X, Krainc D, White MF. IRS2 increases mitochondrial dysfunction and oxidative stress in a mouse model of Huntington disease. The Journal of Clinical Investigation. 121: 4070-81. PMID 21926467 DOI: 10.1172/Jci46305  1
2011 Zhou Y, Lee J, Reno CM, Sun C, Park SW, Chung J, Lee J, Fisher SJ, White MF, Biddinger SB, Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nature Medicine. 17: 356-65. PMID 21317886 DOI: 10.1038/nm.2293  1
2011 Long YC, Cheng Z, Copps KD, White MF. Insulin receptor substrates Irs1 and Irs2 coordinate skeletal muscle growth and metabolism via the Akt and AMPK pathways. Molecular and Cellular Biology. 31: 430-41. PMID 21135130 DOI: 10.1128/MCB.00983-10  1
2011 Wei D, Tao R, Zhang Y, White MF, Dong XC. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. American Journal of Physiology. Endocrinology and Metabolism. 300: E312-20. PMID 21081708 DOI: 10.1152/ajpendo.00524.2010  1
2011 Cheng Z, White MF. Targeting Forkhead box O1 from the concept to metabolic diseases: lessons from mouse models. Antioxidants & Redox Signaling. 14: 649-61. PMID 20615072 DOI: 10.1089/ars.2010.3370  1
2010 Cheng Z, Tseng Y, White MF. Insulin signaling meets mitochondria in metabolism. Trends in Endocrinology and Metabolism: Tem. 21: 589-98. PMID 20638297 DOI: 10.1016/j.tem.2010.06.005  1
2010 Carew RM, Sadagurski M, Goldschmeding R, Martin F, White MF, Brazil DP. Deletion of Irs2 causes reduced kidney size in mice: role for inhibition of GSK3beta? Bmc Developmental Biology. 10: 73. PMID 20604929 DOI: 10.1186/1471-213X-10-73  1
2010 Zaret KS, White MF. Diabetes forum: Extreme makeover of pancreatic alpha-cells. Nature. 464: 1132-3. PMID 20414295 DOI: 10.1038/4641132a  1
2010 Copps KD, Hancer NJ, Opare-Ado L, Qiu W, Walsh C, White MF. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metabolism. 11: 84-92. PMID 20074531 DOI: 10.1016/j.cmet.2009.11.003  1
2010 Liang L, Guo WH, Esquiliano DR, Asai M, Rodriguez S, Giraud J, Kushner JA, White MF, Lopez MF. Insulin-like growth factor 2 and the insulin receptor, but not insulin, regulate fetal hepatic glycogen synthesis. Endocrinology. 151: 741-7. PMID 20032056 DOI: 10.1210/en.2009-0705  1
2010 Cheng Z, White MF. Foxo1 in hepatic lipid metabolism. Cell Cycle (Georgetown, Tex.). 9: 219-20. PMID 20023377 DOI: 10.4161/cc.9.2.10567  1
2010 Sadagurski M, Norquay L, Farhang J, D'Aquino K, Copps K, White MF. Human IL6 enhances leptin action in mice. Diabetologia. 53: 525-35. PMID 19902173 DOI: 10.1007/s00125-009-1580-8  1
2010 Barbieri M, Rizzo MR, Papa M, Boccardi V, Esposito A, White MF, Paolisso G. The IRS2 Gly1057Asp variant is associated with human longevity. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 65: 282-6. PMID 19887537 DOI: 10.1093/gerona/glp154  1
2010 White MF. IRS-Protein scaffolds and insulin/igf action in central and peripheral tissues Handbook of Cell Signaling, 2/E. 3: 2873-2883. DOI: 10.1016/B978-0-12-374145-5.00331-4  1
2009 Cheng Z, Guo S, Copps K, Dong X, Kollipara R, Rodgers JT, Depinho RA, Puigserver P, White MF. Foxo1 integrates insulin signaling with mitochondrial function in the liver. Nature Medicine. 15: 1307-11. PMID 19838201 DOI: 10.1038/Nm.2049  1
2009 Guo S, Copps KD, Dong X, Park S, Cheng Z, Pocai A, Rossetti L, Sajan M, Farese RV, White MF. The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis. Molecular and Cellular Biology. 29: 5070-83. PMID 19596788 DOI: 10.1128/MCB.00138-09  1
2009 Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, White MF. Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology. 150: 4531-40. PMID 19574401 DOI: 10.1210/en.2009-0395  1
2009 White MF. Metformin and insulin meet in a most atypical way. Cell Metabolism. 9: 485-7. PMID 19490902 DOI: 10.1016/j.cmet.2009.05.007  1
2009 Lee DH, Shi J, Jeoung NH, Kim MS, Zabolotny JM, Lee SW, White MF, Wei L, Kim YB. Targeted disruption of ROCK1 causes insulin resistance in vivo. The Journal of Biological Chemistry. 284: 11776-80. PMID 19276091 DOI: 10.1074/jbc.C900014200  1
2009 Copps KD, White MF. Breathing room: the (un)natural history of adipose microhypoxia and insulin resistance. Diabetes. 58: 26-7. PMID 19114728 DOI: 10.2337/db08-1517  1
2009 Szabolcs M, Keniry M, Simpson L, Reid LJ, Koujak S, Schiff SC, Davidian G, Licata S, Gruvberger-Saal S, Murty VV, Nandula S, Efstratiadis A, Kushner JA, White MF, Parsons R. Irs2 inactivation suppresses tumor progression in Pten+/- mice. The American Journal of Pathology. 174: 276-86. PMID 19095950 DOI: 10.2353/Ajpath.2009.080086  1
2008 Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes. 57: 2644-51. PMID 18633112 DOI: 10.2337/db06-0454  1
2008 Dong XC, Copps KD, Guo S, Li Y, Kollipara R, DePinho RA, White MF. Inactivation of hepatic Foxo1 by insulin signaling is required for adaptive nutrient homeostasis and endocrine growth regulation. Cell Metabolism. 8: 65-76. PMID 18590693 DOI: 10.1016/J.Cmet.2008.06.006  1
2008 Tanabe K, Liu Z, Patel S, Doble BW, Li L, Cras-Méneur C, Martinez SC, Welling CM, White MF, Bernal-Mizrachi E, Woodgett JR, Permutt MA. Genetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistance. Plos Biology. 6: e37. PMID 18288891 DOI: 10.1371/journal.pbio.0060037  1
2008 Wu J, Tseng YD, Xu CF, Neubert TA, White MF, Hubbard SR. Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nature Structural & Molecular Biology. 15: 251-8. PMID 18278056 DOI: 10.1038/nsmb.1388  1
2008 Li D, Yin X, Zmuda EJ, Wolford CC, Dong X, White MF, Hai T. The repression of IRS2 gene by ATF3, a stress-inducible gene, contributes to pancreatic beta-cell apoptosis. Diabetes. 57: 635-44. PMID 18057093 DOI: 10.2337/db07-0717  1
2008 Taguchi A, White MF. Insulin-like signaling, nutrient homeostasis, and life span. Annual Review of Physiology. 70: 191-212. PMID 17988211 DOI: 10.1146/annurev.physiol.70.113006.100533  1
2008 Taguchi A, White MF. Response to comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis" Science. 320. DOI: 10.1126/science.1152620  1
2007 Taguchi A, Wartschow LM, White MF. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science (New York, N.Y.). 317: 369-72. PMID 17641201 DOI: 10.1126/science.1142179  1
2007 Giraud J, Haas M, Feener EP, Copps KD, Dong X, Dunn SL, White MF. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Molecular Endocrinology (Baltimore, Md.). 21: 2294-302. PMID 17579213 DOI: 10.1210/me.2007-0159  1
2007 Sadagurski M, Nofech-Mozes S, Weingarten G, White MF, Kadowaki T, Wertheimer E. Insulin receptor substrate 1 (IRS-1) plays a unique role in normal epidermal physiology. Journal of Cellular Physiology. 213: 519-27. PMID 17508357 DOI: 10.1002/jcp.21131  1
2007 Kim JJ, Kido Y, Scherer PE, White MF, Accili D. Analysis of compensatory beta-cell response in mice with combined mutations of Insr and Irs2. American Journal of Physiology. Endocrinology and Metabolism. 292: E1694-701. PMID 17299086 DOI: 10.1152/ajpendo.00430.2006  1
2007 Gonzalez-Navarro H, Vila-Caballer M, Pastor MF, Vinue A, White MF, Burks D, Andres V. Plasma insulin levels predict the development of atherosclerosis when IRS2 deficiency is combined with severe hypercholesterolemia in apolipoprotein E-null mice. Frontiers in Bioscience : a Journal and Virtual Library. 12: 2291-8. PMID 17127239 DOI: 10.2741/2231  1
2006 Ma Z, Gibson SL, Byrne MA, Zhang J, White MF, Shaw LM. Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis. Molecular and Cellular Biology. 26: 9338-51. PMID 17030605 DOI: 10.1128/MCB.01032-06  1
2006 White MF. Regulating insulin signaling and beta-cell function through IRS proteins. Canadian Journal of Physiology and Pharmacology. 84: 725-37. PMID 16998536 DOI: 10.1139/y06-008  1
2006 Guo S, Dunn SL, White MF. The reciprocal stability of FOXO1 and IRS2 creates a regulatory circuit that controls insulin signaling. Molecular Endocrinology (Baltimore, Md.). 20: 3389-99. PMID 16916938 DOI: 10.1210/me.2006-0092  1
2006 Dong X, Park S, Lin X, Copps K, Yi X, White MF. Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. The Journal of Clinical Investigation. 116: 101-14. PMID 16374520 DOI: 10.1172/JCI25735  1
2006 Lee JY, Ristow M, Lin X, White MF, Magnuson MA, Hennighausen L. RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function. The Journal of Biological Chemistry. 281: 2649-53. PMID 16326700 DOI: 10.1074/jbc.M512373200  1
2006 Park S, Dong X, Fisher TL, Dunn S, Omer AK, Weir G, White MF. Exendin-4 uses Irs2 signaling to mediate pancreatic beta cell growth and function. The Journal of Biological Chemistry. 281: 1159-68. PMID 16272563 DOI: 10.1074/jbc.M508307200  1
2005 Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, Neschen S, White MF, Bilz S, Sono S, Pypaert M, Shulman GI. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents. The Journal of Clinical Investigation. 115: 3587-93. PMID 16284649 DOI: 10.1172/JCI25151  1
2005 Kushner JA, Simpson L, Wartschow LM, Guo S, Rankin MM, Parsons R, White MF. Phosphatase and tensin homolog regulation of islet growth and glucose homeostasis. The Journal of Biological Chemistry. 280: 39388-93. PMID 16170201 DOI: 10.1074/jbc.M504155200  1
2005 Clough MH, Schneider DJ, Sobel BE, White MF, Wadsworth MP, Taatjes DJ. Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E Journal of Histochemistry and Cytochemistry. 53: 603-610. PMID 15872053 DOI: 10.1369/jhc.4A6590.2005  1
2005 Kushner JA, Ciemerych MA, Sicinska E, Wartschow LM, Teta M, Long SY, Sicinski P, White MF. Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth. Molecular and Cellular Biology. 25: 3752-62. PMID 15831479 DOI: 10.1128/Mcb.25.9.3752-3762.2005  1
2005 Hennige AM, Ozcan U, Okada T, Jhala US, Schubert M, White MF, Kulkarni RN. Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. American Journal of Physiology. Endocrinology and Metabolism. 289: E337-46. PMID 15827066 DOI: 10.1152/ajpendo.00032.2004  1
2005 Sadagurski M, Weingarten G, Rhodes CJ, White MF, Wertheimer E. Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport. The Journal of Biological Chemistry. 280: 14536-44. PMID 15705592 DOI: 10.1074/jbc.M410227200  1
2005 Yi X, Schubert M, Peachey NS, Suzuma K, Burks DJ, Kushner JA, Suzuma I, Cahill C, Flint CL, Dow MA, Leshan RL, King GL, White MF. Insulin receptor substrate 2 is essential for maturation and survival of photoreceptor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1240-8. PMID 15689562 DOI: 10.1523/Jneurosci.3664-04.2005  1
2005 Uchida T, Nakamura T, Hashimoto N, Matsuda T, Kotani K, Sakaue H, Kido Y, Hayashi Y, Nakayama KI, White MF, Kasuga M. Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice. Nature Medicine. 11: 175-82. PMID 15685168 DOI: 10.1038/nm1187  1
2004 Fisher TL, White MF. Signaling pathways: the benefits of good communication. Current Biology : Cb. 14: R1005-7. PMID 15589136 DOI: 10.1016/j.cub.2004.11.024  1
2004 Valverde AM, Fabregat I, Burks DJ, White MF, Benito M. IRS-2 mediates the antiapoptotic effect of insulin in neonatal hepatocytes. Hepatology (Baltimore, Md.). 40: 1285-94. PMID 15565601 DOI: 10.1002/hep.20485  1
2004 Nagle JA, Ma Z, Byrne MA, White MF, Shaw LM. Involvement of insulin receptor substrate 2 in mammary tumor metastasis. Molecular and Cellular Biology. 24: 9726-35. PMID 15509777 DOI: 10.1128/MCB.24.22.9726-9735.2004  1
2004 Lin X, Taguchi A, Park S, Kushner JA, Li F, Li Y, White MF. Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes. The Journal of Clinical Investigation. 114: 908-16. PMID 15467829 DOI: 10.1172/JCI22217  1
2004 Duan C, Yang H, White MF, Rui L. Disruption of the SH2-B gene causes age-dependent insulin resistance and glucose intolerance. Molecular and Cellular Biology. 24: 7435-43. PMID 15314154 DOI: 10.1128/MCB.24.17.7435-7443.2004  1
2004 Lee YH, White MF. Insulin receptor substrate proteins and diabetes. Archives of Pharmacal Research. 27: 361-70. PMID 15180298  1
2004 Carlson CJ, White MF, Rondinone CM. Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation. Biochemical and Biophysical Research Communications. 316: 533-9. PMID 15020250 DOI: 10.1016/j.bbrc.2004.02.082  1
2004 Fujii N, Boppart MD, Dufresne SD, Crowley PF, Jozsi AC, Sakamoto K, Yu H, Aschenbach WG, Kim S, Miyazaki H, Rui L, White MF, Hirshman MF, Goodyear LJ. Overexpression or ablation of JNK in skeletal muscle has no effect on glycogen synthase activity. American Journal of Physiology. Cell Physiology. 287: C200-8. PMID 15013949 DOI: 10.1152/ajpcell.00415.2003  1
2004 Kushner JA, Haj FG, Klaman LD, Dow MA, Kahn BB, Neel BG, White MF. Islet-sparing effects of protein tyrosine phosphatase-1b deficiency delays onset of diabetes in IRS2 knockout mice. Diabetes. 53: 61-6. PMID 14693698 DOI: 10.2337/diabetes.53.1.61  1
2004 Giraud J, Leshan R, Lee YH, White MF. Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. The Journal of Biological Chemistry. 279: 3447-54. PMID 14623899 DOI: 10.1074/jbc.M308631200  1
2003 White MF. Insulin signaling in health and disease. Science (New York, N.Y.). 302: 1710-1. PMID 14657487 DOI: 10.1126/science.1092952  1
2003 Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF. Upregulation of insulin receptor substrate-2 in pancreatic beta cells prevents diabetes. The Journal of Clinical Investigation. 112: 1521-32. PMID 14617753 DOI: 10.1172/JCI18581  1
2003 Valverde AM, Burks DJ, Fabregat I, Fisher TL, Carretero J, White MF, Benito M. Molecular mechanisms of insulin resistance in IRS-2-deficient hepatocytes. Diabetes. 52: 2239-48. PMID 12941762 DOI: 10.2337/diabetes.52.9.2239  1
2003 Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF. Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 7084-92. PMID 12904469  1
2003 Arribas M, Valverde AM, Burks D, Klein J, Farese RV, White MF, Benito M. Essential role of protein kinase C zeta in the impairment of insulin-induced glucose transport in IRS-2-deficient brown adipocytes. Febs Letters. 536: 161-6. PMID 12586357  0.36
2003 Lee YH, Giraud J, Davis RJ, White MF. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. The Journal of Biological Chemistry. 278: 2896-902. PMID 12417588 DOI: 10.1074/jbc.M208359200  1
2003 White MF. IRS-Protein Scaffolds and Insulin/IGF Action Handbook of Cell Signaling. 1: 409-419. DOI: 10.1016/B978-012124546-7/50433-2  1
2002 Chang Q, Li Y, White MF, Fletcher JA, Xiao S. Constitutive activation of insulin receptor substrate 1 is a frequent event in human tumors: therapeutic implications. Cancer Research. 62: 6035-8. PMID 12414625  1
2002 Xuan S, Kitamura T, Nakae J, Politi K, Kido Y, Fisher PE, Morroni M, Cinti S, White MF, Herrera PL, Accili D, Efstratiadis A. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. The Journal of Clinical Investigation. 110: 1011-9. PMID 12370279 DOI: 10.1172/Jci15276  1
2002 Rui L, Yuan M, Frantz D, Shoelson S, White MF. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2 Journal of Biological Chemistry. 277: 42394-42398. PMID 12228220 DOI: 10.1074/Jbc.C200444200  1
2002 White MF. IRS proteins and the common path to diabetes. American Journal of Physiology. Endocrinology and Metabolism. 283: E413-22. PMID 12169433 DOI: 10.1152/ajpendo.00514.2001  1
2002 Rhodes CJ, White MF. Molecular insights into insulin action and secretion European Journal of Clinical Investigation. 32: 3-13. PMID 12028370 DOI: 10.1046/J.1365-2362.32.S3.2.X  1
2002 Wurster AL, Rodgers VL, White MF, Rothstein TL, Grusby MJ. Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. The Journal of Biological Chemistry. 277: 27169-75. PMID 12023955 DOI: 10.1074/jbc.M201207200  1
2002 Yu C, Chen Y, Cline GW, Zhang D, Zong H, Wang Y, Bergeron R, Kim JK, Cushman SW, Cooney GJ, Atcheson B, White MF, Kraegen EW, Shulman GI. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. The Journal of Biological Chemistry. 277: 50230-6. PMID 12006582 DOI: 10.1074/jbc.M200958200  1
2002 Kushner JA, Ye J, Schubert M, Burks DJ, Dow MA, Flint CL, Dutta S, Wright CV, Montminy MR, White MF. Pdx1 restores beta cell function in Irs2 knockout mice. The Journal of Clinical Investigation. 109: 1193-201. PMID 11994408 DOI: 10.1172/JCI14439  1
2002 Aguirre V, Werner ED, Giraud J, Lee YH, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. The Journal of Biological Chemistry. 277: 1531-7. PMID 11606564 DOI: 10.1074/jbc.M101521200  1
2001 Mendez R, Welsh G, Kleijn M, Myers MG, White MF, Proud CG, Rhoads RE. Regulation of protein synthesis by insulin through IRS-1 Progress in Molecular and Subcellular Biology. 26: 49-93. PMID 11575167  1
2001 Rui L, Fisher TL, Thomas J, White MF. Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. The Journal of Biological Chemistry. 276: 40362-7. PMID 11546773 DOI: 10.1074/jbc.M105332200  1
2001 Burks DJ, White MF. IRS proteins and beta-cell function Diabetes. 50. PMID 11272176 DOI: 10.2337/DIABETES.50.2007.S140  1
2001 Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF. Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. The Journal of Clinical Investigation. 107: 181-9. PMID 11160134 DOI: 10.1172/Jci10934  0.84
2000 Burks DJ, Font de Mora J, Schubert M, Withers DJ, Myers MG, Towery HH, Altamuro SL, Flint CL, White MF. IRS-2 pathways integrate female reproduction and energy homeostasis. Nature. 407: 377-82. PMID 11014193 DOI: 10.1038/35030105  1
2000 Previs SF, Withers DJ, Ren JM, White MF, Shulman GI. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo Journal of Biological Chemistry. 275: 38990-38994. PMID 10995761 DOI: 10.1074/jbc.M006490200  1
2000 Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). The Journal of Biological Chemistry. 275: 9047-54. PMID 10722755  0.84
2000 Kido Y, Burks DJ, Withers D, Bruning JC, Kahn CR, White MF, Accili D. Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2 Journal of Clinical Investigation. 105: 199-205. PMID 10642598 DOI: 10.1172/JCI7917  1
2000 Uchida T, Myers MG, White MF. IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis Molecular and Cellular Biology. 20: 126-138. PMID 10594015 DOI: 10.1128/MCB.20.1.126-138.2000  1
2000 Aguirre V, White MF. Dysregulation of IRS-proteins causes insulin resistance and diabetes Current Opinion in Endocrinology and Diabetes. 7: 1-7. DOI: 10.1097/00060793-200002000-00001  1
1999 Withers DJ, Burks DJ, Towery HH, Altamuro SL, Flint CL, White MF. Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nature Genetics. 23: 32-40. PMID 10471495 DOI: 10.1038/12631  1
1999 Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes. 48: 1270-4. PMID 10342815 DOI: 10.2337/Diabetes.48.6.1270  1
1999 Withers DJ, White MF. Insulin action and type 2 diabetes: Lessons from knockout mice Current Opinion in Endocrinology and Diabetes. 6: 141-145. DOI: 10.1097/00060793-199904000-00010  1
1998 Burks DJ, Wang J, Towery H, Ishibashi O, Lowe D, Riedel H, White MF. IRS pleckstrin homology domains bind to acidic motifs in proteins Journal of Biological Chemistry. 273: 31061-31067. PMID 9813005 DOI: 10.1074/jbc.273.47.31061  1
1998 Hügl SR, White MF, Rhodes CJ. Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS- 1 cells Journal of Biological Chemistry. 273: 17771-17779. PMID 9651378 DOI: 10.1074/jbc.273.28.17771  1
1998 White MF. The IRS-signalling system: A network of docking proteins that mediate insulin action Molecular and Cellular Biochemistry. 182: 3-11. PMID 9609109 DOI: 10.1023/A:1006806722619  1
1998 Jackson JG, White MF, Yee D. Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. The Journal of Biological Chemistry. 273: 9994-10003. PMID 9545345 DOI: 10.1074/jbc.273.16.9994  1
1998 Withers DJ, Gutierrez JS, Towery H, Burks DJ, Ren JM, Previs S, Zhang Y, Bernal D, Pons S, Shulman GI, Bonner-Weir S, White MF. Disruption of IRS-2 causes type 2 diabetes in mice. Nature. 391: 900-4. PMID 9495343 DOI: 10.1038/36116  1
1997 Joyal JL, Burks DJ, Pons S, Matter WF, Vlahos CJ, White MF, Sacks DB. Calmodulin activates phosphatidylinositol 3-kinase Journal of Biological Chemistry. 272: 28183-28186. PMID 9353264 DOI: 10.1074/jbc.272.45.28183  1
1997 Burks DJ, Pons S, Towery H, Smith-Hall J, Myers MG, Yenush L, White MF. Heterologous pleckstrin homology domains do not couple IRS-1 to the insulin receptor Journal of Biological Chemistry. 272: 27716-27721. PMID 9346913 DOI: 10.1074/jbc.272.44.27716  1
1997 Mendez R, Kollmorgen G, White MF, Rhoads RE. Requirement of protein kinase Cζ for stimulation of protein synthesis by insulin Molecular and Cellular Biology. 17: 5184-5192. PMID 9271396  1
1997 White MF. The insulin signalling system and the IRS proteins Diabetologia. 40. PMID 9248696 DOI: 10.1007/s001250051387  1
1997 Smith-Hall J, Pons S, Patti ME, Burks DJ, Yenush L, Sun XJ, Kahn CR, White MF. The 60 kDA insulin receptor substrate functions like an IRS protein (pp60(IRS3)) in adipose cells Biochemistry. 36: 8304-8310. PMID 9204876 DOI: 10.1021/bi9630974  1
1997 Yenush L, White MF. The IRS-signalling system during insulin and cytokine action Bioessays. 19: 491-500. PMID 9204766 DOI: 10.1002/bies.950190608  1
1996 Smith RM, Zhang S, White MF, Jarett L. The role of receptor kinase activity and the NPEY960 motif in insulin-accelerated receptor-mediated insulin internalization Journal of Receptor and Signal Transduction Research. 16: 339-355. PMID 8968965 DOI: 10.3109/10799899609039955  1
1996 Munshi HG, Burks DJ, Joyal JL, White MF, Sacks DB. Ca2+ regulates calmodulin binding to IQ motifs in IRS-1 Biochemistry. 35: 15883-15889. PMID 8961953 DOI: 10.1021/bi962107y  1
1996 Argetsinger LS, Norstedt G, Billestrup N, White MF, Carter-Su C. Growth hormone, interferon-γ, and leukemia inhibitory factor utilize insulin receptor substrate-2 in intracellular signaling Journal of Biological Chemistry. 271: 29415-29421. PMID 8910607 DOI: 10.1074/jbc.271.46.29415  1
1996 Myers MG, Zhang Y, Aldaz GA, Grammer T, Glasheen EM, Yenush L, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Molecular and Cellular Biology. 16: 4147-55. PMID 8754813 DOI: 10.1128/Mcb.16.8.4147  1
1996 Myers MG, White MF. Insulin signal transduction and the IRS proteins Annual Review of Pharmacology and Toxicology. 36: 615-658. PMID 8725404 DOI: 10.1146/  1
1996 Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. The Journal of Biological Chemistry. 271: 13018-22. PMID 8662983 DOI: 10.1074/Jbc.271.22.13018  1
1996 White MF. The IRS-signalling system in insulin and cytokine action Philosophical Transactions of the Royal Society B: Biological Sciences. 351: 181-189. PMID 8650265 DOI: 10.1098/rstb.1996.0015  1
1996 Mendez R, Myers MG, White MF, Rhoads RE. Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase Molecular and Cellular Biology. 16: 2857-2864. PMID 8649395  1
1996 Yenush L, Fernandez R, Myers MG, Grammer TC, Sun XJ, Blenis J, Pierce JH, Schlessinger J, White MF. The Drosophila insulin receptor activates multiple signaling pathways but requires insulin receptor substrate proteins for DNA synthesis. Molecular and Cellular Biology. 16: 2509-17. PMID 8628319 DOI: 10.1128/Mcb.16.5.2509  1
1996 Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (New York, N.Y.). 271: 665-8. PMID 8571133 DOI: 10.1126/Science.271.5249.665  1
1995 Rordorf-Nikolic T, Van Horn DJ, Chen D, White MF, Backer JM. Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit Journal of Biological Chemistry. 270: 3662-3666. PMID 7876105 DOI: 10.1074/jbc.270.8.3662  1
1995 Argetsinger LS, Hsu GW, Myers MG, Billestrup N, White MF, Carter-Su C. Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. The Journal of Biological Chemistry. 270: 14685-92. PMID 7782332 DOI: 10.1074/jbc.270.24.14685  1
1995 Myers MG, Grammer TC, Brooks J, Glasheen EM, Wang LM, Sun XJ, Blenis J, Pierce JH, White MF. The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. The Journal of Biological Chemistry. 270: 11715-8. PMID 7744813 DOI: 10.1074/Jbc.270.20.11715  1
1995 Chen D, Van Horn DJ, White MF, Backer JM. Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif Molecular and Cellular Biology. 15: 4711-4717. PMID 7651388 DOI: 10.1128/MCB.15.9.4711  1
1995 Kotanides H, Moczygemba M, White MF, Reich NC. Characterization of the interleukin-4 nuclear activated factor/STAT and its activation independent of the insulin receptor substrate proteins Journal of Biological Chemistry. 270: 19481-19486. PMID 7642632 DOI: 10.1074/jbc.270.33.19481  1
1995 Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL, Myers MG, Sun XJ, White MF. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 15: 4453-65. PMID 7542745  1
1995 Uddin S, Katzav S, White MF, Platanias LC. Insulin-dependent tyrosine phosphorylation of the vav protooncogene product in cells of hematopoietic origin Journal of Biological Chemistry. 270: 7712-7716. PMID 7535775 DOI: 10.1074/jbc.270.13.7712  1
1995 Johnston JA, Wang LM, Hanson EP, Sun XJ, White MF, Oakes SA, Pierce JH, O'Shea JJ. Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. The Journal of Biological Chemistry. 270: 28527-30. PMID 7499365 DOI: 10.1074/jbc.270.48.28527  1
1995 Wolf G, Trüb T, Ottinger E, Groninga L, Lynch A, White MF, Miyazaki M, Lee J, Shoelson SE. PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. The Journal of Biological Chemistry. 270: 27407-10. PMID 7499194 DOI: 10.1074/Jbc.270.46.27407  1
1995 Myers MG, Cheatham B, Fisher TL, Jachna BR, Kahn CR, Backer JM, White MF. Common and distinct elements in insulin and PDGF signaling. Annals of the New York Academy of Sciences. 766: 369-87. PMID 7486683 DOI: 10.1111/j.1749-6632.1995.tb26687.x  1
1995 Myers MG, White MF. New frontiers in insulin receptor substrate signaling Trends in Endocrinology and Metabolism. 6: 209-215. DOI: 10.1016/1043-2760(95)00092-V  1
1994 White MF. The IRS-1 signaling system Current Opinion in Genetics and Development. 4: 47-54. PMID 8193539 DOI: 10.1016/0959-437X(94)90090-6  1
1994 Baskin DG, Schwartz MW, Sipols AJ, D'Alessio DA, Goldstein BJ, White MF. Insulin receptor substrate-1 (IRS-1) expression in rat brain. Endocrinology. 134: 1952-5. PMID 7511094 DOI: 10.1210/Endo.134.4.7511094  1
1993 Chuang LM, Myers MG, Backer JM, Shoelson SE, White MF, Birnbaum MJ, Kahn CR. Insulin-stimulated oocyte maturation requires insulin receptor substrate 1 and interaction with the SH2 domains of phosphatidylinositol 3-kinase. Molecular and Cellular Biology. 13: 6653-60. PMID 8413261 DOI: 10.1128/Mcb.13.11.6653  1
1993 Myers MG, White MF. The new elements of insulin signaling: Insulin receptor substrate-1 and proteins with SH2 domains Diabetes. 42: 643-650. PMID 8387037 DOI: 10.2337/diab.42.5.643  1
1993 Myers MG, Sun XJ, Cheatham B, Jachna BR, Glasheen EM, Backer JM, White MF. IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3′-kinase Endocrinology. 132: 1421-1430. PMID 8384986 DOI: 10.1210/endo.132.4.8384986  1
1993 Lee CH, Li W, Nishimura R, Zhou M, Batzer AG, Myers MG, White MF, Schlessinger J, Skolnik EY. Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 11713-7. PMID 8265614 DOI: 10.1073/Pnas.90.24.11713  1
1993 Wang LM, Keegan AD, Li W, Lienhard GE, Pacini S, Gutkind JS, Myers MG, Sun XJ, White MF, Aaronson SA, Paul WE, Pierce JH. Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells Proceedings of the National Academy of Sciences of the United States of America. 90: 4032-4036. PMID 7683417 DOI: 10.1073/pnas.90.9.4032  1
1993 Kahn CR, White MF, Shoelson SE, Backer JM, Araki E, Cheatham B, Csermely P, Folli F, Goldstein BJ, Huertas P. The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Progress in Hormone Research. 48: 291-339. PMID 7680139 DOI: 10.1016/B978-0-12-571148-7.50015-4  1
1993 Baskin DG, Sipols AJ, Schwartz MW, White MF. Immunocytochemical detection of insulin receptor substrate-1 (IRS-1) in rat brain: colocalization with phosphotyrosine. Regulatory Peptides. 48: 257-66. PMID 7505468 DOI: 10.1016/0167-0115(93)90355-C  1
1992 Backer JM, Shoelson SE, Weiss MA, Hua QX, Cheatham RB, Haring E, Cahill DC, White MF. The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. The Journal of Cell Biology. 118: 831-9. PMID 1500426 DOI: 10.1083/Jcb.118.4.831  1
1992 Miralpeix M, Sun XJ, Backer JM, Myers MG, Araki E, White MF. Insulin stimulates tyrosine phosphorylation of multiple high molecular weight substrates in Fao hepatoma cells Biochemistry. 31: 9031-9039. PMID 1382584 DOI: 10.1021/bi00152a046  1
1992 Myers MG, Backer JM, Sun XJ, Shoelson S, Hu P, Schlessinger J, Yoakim M, Schaffhausen B, White MF. IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the United States of America. 89: 10350-4. PMID 1332046 DOI: 10.1073/Pnas.89.21.10350  1
1992 Shoelson SE, Chatterjee S, Chaudhuri M, White MF. YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proceedings of the National Academy of Sciences of the United States of America. 89: 2027-31. PMID 1312712 DOI: 10.1073/Pnas.89.6.2027  1
1991 Okamoto M, Karasik A, White MF, Kahn CR. Coordinate phosphorylation of insulin-receptor kinase and its 175,000-Mr endogenous substrate in rat hepatocytes Diabetes. 40: 66-72. PMID 1849850 DOI: 10.2337/diab.40.1.66  1
1991 White MF. Structure and function of tyrosine kinase receptors Journal of Bioenergetics and Biomembranes. 23: 63-82. PMID 1849136 DOI: 10.1007/BF00768839  1
1991 Backer JM, Shoelson SE, Haring E, White MF. Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region. The Journal of Cell Biology. 115: 1535-45. PMID 1757462 DOI: 10.1083/Jcb.115.6.1535  1
1991 White MF, Backer JM. Preparation and use of anti-phosphotyrosine antibodies to study structure and function of insulin receptor Methods in Enzymology. 201: 65-79. PMID 1719349 DOI: 10.1016/0076-6879(91)01009-Q  1
1991 Segatto O, Lonardo F, Wexler D, Fazioli F, Pierce JH, Bottaro DP, White MF, Di Fiore PP. The juxtamembrane regions of the epidermal growth factor receptor and gp185erbB-2 determine the specificity of signal transduction. Molecular and Cellular Biology. 11: 3191-202. PMID 1674818 DOI: 10.1128/MCB.11.6.3191  0.32
1991 Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ, White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein Nature. 352: 73-76. PMID 1648180 DOI: 10.1038/352073a0  1
1990 Okamoto M, Karasik A, White MF, Kahn CR. Epidermal growth factor stimulated phosphorylation of a 120-kilodalton endogenous substrate protein in rat hepatocytes Biochemistry®. 29: 9489-9494. PMID 2248961 DOI: 10.1021/bi00492a023  1
1990 Wilden PA, Backer JM, Kahn CR, Cahill DA, Schroeder GJ, White MF. The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth Proceedings of the National Academy of Sciences of the United States of America. 87: 3358-3362. PMID 2159147 DOI: 10.1073/pnas.87.9.3358  1
1990 Kruszynska YT, Halban PA, Kahn CR, White MF. Activation of liver and muscle insulin receptor tyrosine kinase activity during in vivo insulin administration in rats Diabetologia. 33: 77-83. PMID 2158467 DOI: 10.1007/BF00401044  1
1990 Ruderman NB, Kapeller R, White MF, Cantley LC. Activation of phosphatidylinositol 3-kinase by insulin Proceedings of the National Academy of Sciences of the United States of America. 87: 1411-1415. PMID 2154747 DOI: 10.1073/Pnas.87.4.1411  1
1989 White MF, Kahn CR. Cascade of autophosphorylation in the beta-subunit of the insulin receptor Journal of Cellular Biochemistry. 39: 429-441. PMID 2722971 DOI: 10.1002/jcb.240390409  1
1989 Shymko RM, Gonzales NS, Backer JM, White MF, Meyts PD. Binding kinetics of mutated insulin receptors in transfected cells grown in suspension culture: Application to the Tyr → Phe 960 insulin receptor mutant Biochemical and Biophysical Research Communications. 164: 191-198. PMID 2508634 DOI: 10.1016/0006-291X(89)91701-4  1
1989 Backer JM, Kahn CR, White MF. Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: Studies in 2,4-dinitrophenol-treated cells Proceedings of the National Academy of Sciences of the United States of America. 86: 3209-3213. PMID 2470095 DOI: 10.1073/pnas.86.9.3209  1
1989 Hofmann C, White MF, Whittaker J. Human insulin receptors expressed in insulin-insensitive mouse fibroblasts couple with extant cellular effector system to confer insulin sensitivity and responsiveness Endocrinology. 124: 257-264. PMID 2462489 DOI: 10.1210/endo-124-1-257  1
1988 Kahn CR, White MF. The insulin receptor and the molecular mechanism of insulin action Journal of Clinical Investigation. 82: 1151-1156. PMID 3049671 DOI: 10.1172/JCI113711  1
1988 White MF, Livingston JN, Backer JM, Lauris V, Dull TJ, Ullrich A, Kahn CR. Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity Cell. 54: 641-649. PMID 2842060 DOI: 10.1016/S0092-8674(88)80008-4  1
1988 Okamoto M, Kahn CR, Maron R, White MF. Decreased autophosphorylation of EGF receptor in insulin-deficient diabetic rats American Journal of Physiology - Endocrinology and Metabolism. 254. PMID 2833110 DOI: 10.1152/ajpendo.1988.254.4.E429  1
1988 Morrison DK, Browning PJ, White MF, Roberts TM. Tyrosine phosphorylations in vivo associated with v-fms transformation Molecular and Cellular Biology. 8: 176-185. PMID 2447483 DOI: 10.1128/MCB.8.1.176  1
1987 Machicao F, Haring H, White MF. An M(r) 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta Biochemical Journal. 243: 797-801. PMID 2821993 DOI: 10.1042/bj2430797  1
1987 Carpentier JL, White MF, Orci L, Kahn RC. Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells Journal of Cell Biology. 105: 2751-2762. PMID 2447100 DOI: 10.1083/jcb.105.6.2751  1
1987 Sale EM, White MF, Kahn CR. Phosphorylation of glycolytic and gluconeogenic enzymes by the insulin receptor kinase Journal of Cellular Biochemistry. 33: 15-26. PMID 2434517 DOI: 10.1002/jcb.240330103  1
1986 Okamoto M, White MF, Maron R, Kahn CR. Autophosphorylation and kinase activity of insulin receptor in diabetic rats American Journal of Physiology - Endocrinology and Metabolism. 251. PMID 2430467 DOI: 10.1152/ajpendo.1986.251.5.E542  1
1986 White MF, Kahn CR. 7 The Insulin Receptor and Tyrosine Phosphorylation Enzymes. 17: 247-310. DOI: 10.1016/S1874-6047(08)60432-1  1
1985 Kasuga M, White MF, Kahn CR. Phosphorylation of the insulin receptor in cultured hepatoma cells and a solubilized system Methods in Enzymology. 609-621. PMID 3990573 DOI: 10.1016/0076-6879(85)09118-2  1
1985 Haring HU, White MF, Kahn CR, Ahmad Z, DePaoli-Roach AA, Roach PJ. Interaction of the insulin receptor kinase with serine/threonine kinases in vitro Journal of Cellular Biochemistry. 28: 171-182. PMID 3001107 DOI: 10.1002/jcb.240280209  1
1985 White MF, Maron R, Kahn CR. Insulin rapidly stimulates tyrosine phosphorylation of a M r-185,000 protein in intact cells Nature. 318: 183-186. PMID 2414672 DOI: 10.1038/318183a0  1
1984 Takayama S, White MF, Lauris V, Kahn CR. Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells Proceedings of the National Academy of Sciences of the United States of America. 81: 7797-7801. PMID 6393128 DOI: 10.1073/pnas.81.24.7797  1
1984 White MF, Werth DK, Pastan I, Kahn CR. Phosphorylation of the solubilized insulin receptor by the gene product of the Rous sarcoma virus, pp60(src) Journal of Cellular Biochemistry. 26: 169-179. PMID 6098589 DOI: 10.1002/jcb.240260305  1
1983 White MF, Christensen HN. Simultaneous regulation of amino acid influx and efflux by System A in the hepatoma cell HTC. Ouabain simulates the starvation-induced derepression of System A amino acid transport Journal of Biological Chemistry. 258: 8028-8038. PMID 6863276  1
1982 White MF, Christensen HN. The two-way flux of cationic amino acids across the plasma membrane of mammalian cells is largely explained by a single transport system Journal of Biological Chemistry. 257: 10069-10080. PMID 7107597  1
1982 White MF, Christensen HN. Cationic amino acid transport into cultured animal cells. II. Transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines Journal of Biological Chemistry. 257: 4450-4457. PMID 7068644  1
1982 White MF, Gazzola GC, Christensen HN. Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblast Journal of Biological Chemistry. 257: 4443-4449. PMID 7040384  1
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