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Alexandra S. Ioanoviciu, Ph.D. - Publications

Affiliations: 
2005 Purdue University, West Lafayette, IN, United States 
Area:
Pharmaceutical Chemistry, Organic Chemistry
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4 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2006 Nagarajan M, Morrell A, Ioanoviciu A, Antony S, Kohlhagen G, Agama K, Hollingshead M, Pommier Y, Cushman M. Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles. Journal of Medicinal Chemistry. 49: 6283-9. PMID 17034134 DOI: 10.1021/Jm060564Z  0.549
2006 Morrell A, Jayaraman M, Nagarajan M, Fox BM, Meckley MR, Ioanoviciu A, Pommier Y, Antony S, Hollingshead M, Cushman M. Evaluation of indenoisoquinoline topoisomerase I inhibitors using a hollow fiber assay. Bioorganic & Medicinal Chemistry Letters. 16: 4395-9. PMID 16750365 DOI: 10.1016/J.Bmcl.2006.05.048  0.512
2006 Marchand C, Antony S, Kohn KW, Cushman M, Ioanoviciu A, Staker BL, Burgin AB, Stewart L, Pommier Y. A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex. Molecular Cancer Therapeutics. 5: 287-95. PMID 16505102 DOI: 10.1158/1535-7163.Mct-05-0456  0.495
2005 Ioanoviciu A, Antony S, Pommier Y, Staker BL, Stewart L, Cushman M. Synthesis and mechanism of action studies of a series of norindenoisoquinoline topoisomerase I poisons reveal an inhibitor with a flipped orientation in the ternary DNA-enzyme-inhibitor complex as determined by X-ray crystallographic analysis. Journal of Medicinal Chemistry. 48: 4803-14. PMID 16033260 DOI: 10.1021/Jm050076B  0.538
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