Peter Dedon, M.D., Ph.D. - Publications

Affiliations: 
Biological Engineering Massachusetts Institute of Technology, Cambridge, MA, United States 
Area:
Biological chemistry of nucleic acids

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Thiaville JJ, Kellner SM, Yuan Y, Hutinet G, Thiaville PC, Jumpathong W, Mohapatra S, Brochier-Armanet C, Letarov AV, Hillebrand R, Malik CK, Rizzo CJ, Dedon PC, de Crécy-Lagard V. Novel genomic island modifies DNA with 7-deazaguanine derivatives. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929322 DOI: 10.1073/pnas.1518570113  0.96
2015 Deng W, Babu IR, Su D, Yin S, Begley TJ, Dedon PC. Trm9-Catalyzed tRNA Modifications Regulate Global Protein Expression by Codon-Biased Translation. Plos Genetics. 11: e1005706. PMID 26670883 DOI: 10.1371/journal.pgen.1005706  0.96
2015 Jumpathong W, Chan W, Taghizadeh K, Babu IR, Dedon PC. Metabolic fate of endogenous molecular damage: Urinary glutathione conjugates of DNA-derived base propenals as markers of inflammation. Proceedings of the National Academy of Sciences of the United States of America. 112: E4845-53. PMID 26283391 DOI: 10.1073/pnas.1503945112  0.96
2015 Cao B, Zheng X, Cheng Q, Yao F, Zheng T, Ramesh Babu I, Zhou H, Dedon P, You D. In vitro analysis of phosphorothioate modification of DNA reveals substrate recognition by a multiprotein complex. Scientific Reports. 5: 12513. PMID 26213215 DOI: 10.1038/srep12513  0.96
2015 Chan CT, Deng W, Li F, DeMott MS, Babu IR, Begley TJ, Dedon PC. Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes. Chemical Research in Toxicology. 28: 978-88. PMID 25772370 DOI: 10.1021/acs.chemrestox.5b00004  0.96
2015 Hia F, Chionh YH, Pang YL, DeMott MS, McBee ME, Dedon PC. Mycobacterial RNA isolation optimized for non-coding RNA: high fidelity isolation of 5S rRNA from Mycobacterium bovis BCG reveals novel post-transcriptional processing and a complete spectrum of modified ribonucleosides. Nucleic Acids Research. 43: e32. PMID 25539917 DOI: 10.1093/nar/gku1317  0.96
2015 Zeiger E, Gollapudi B, Aardema MJ, Auerbach S, Boverhof D, Custer L, Dedon P, Honma M, Ishida S, Kasinski AL, Kim JH, Manjanatha MG, Marlowe J, Pfuhler S, Pogribny I, et al. Opportunities to integrate new approaches in genetic toxicology: an ILSI-HESI workshop report. Environmental and Molecular Mutagenesis. 56: 277-85. PMID 25482136 DOI: 10.1002/em.21923  0.96
2015 Cai WM, Chionh YH, Hia F, Gu C, Kellner S, McBee ME, Ng CS, Pang YLJ, Prestwich EG, Lim KS, Ramesh Babu I, Begley TJ, Dedon PC. A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications Methods in Enzymology. DOI: 10.1016/bs.mie.2015.03.004  0.96
2014 Batista PJ, Molinie B, Wang J, Qu K, Zhang J, Li L, Bouley DM, Lujan E, Haddad B, Daneshvar K, Carter AC, Flynn RA, Zhou C, Lim KS, Dedon P, et al. m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells. Cell Stem Cell. 15: 707-19. PMID 25456834 DOI: 10.1016/j.stem.2014.09.019  0.96
2014 Ribas de Pouplana L, Dedon PC. More than an adaptor molecule: the emerging role of tRNA in cell signaling and disease. Febs Letters. 588: 4267. PMID 25448597 DOI: 10.1016/j.febslet.2014.10.022  0.96
2014 Pang YL, Abo R, Levine SS, Dedon PC. Diverse cell stresses induce unique patterns of tRNA up- and down-regulation: tRNA-seq for quantifying changes in tRNA copy number. Nucleic Acids Research. 42: e170. PMID 25348403 DOI: 10.1093/nar/gku945  0.96
2014 Gu C, Begley TJ, Dedon PC. tRNA modifications regulate translation during cellular stress. Febs Letters. 588: 4287-96. PMID 25304425 DOI: 10.1016/j.febslet.2014.09.038  0.96
2014 Cao B, Cheng Q, Gu C, Yao F, DeMott MS, Zheng X, Deng Z, Dedon PC, You D. Pathological phenotypes and in vivo DNA cleavage by unrestrained activity of a phosphorothioate-based restriction system in Salmonella. Molecular Microbiology. 93: 776-85. PMID 25040300 DOI: 10.1111/mmi.12692  0.96
2014 Cao B, Chen C, DeMott MS, Cheng Q, Clark TA, Xiong X, Zheng X, Butty V, Levine SS, Yuan G, Boitano M, Luong K, Song Y, Zhou X, Deng Z, ... ... Dedon PC, et al. Genomic mapping of phosphorothioates reveals partial modification of short consensus sequences. Nature Communications. 5: 3951. PMID 24899568 DOI: 10.1038/ncomms4951  0.96
2014 Su D, Chan CT, Gu C, Lim KS, Chionh YH, McBee ME, Russell BS, Babu IR, Begley TJ, Dedon PC. Quantitative analysis of ribonucleoside modifications in tRNA by HPLC-coupled mass spectrometry. Nature Protocols. 9: 828-41. PMID 24625781 DOI: 10.1038/nprot.2014.047  0.96
2014 Courtes FC, Gu C, Wong NS, Dedon PC, Yap MG, Lee DY. 28S rRNA is inducibly pseudouridylated by the mTOR pathway translational control in CHO cell cultures. Journal of Biotechnology. 174: 16-21. PMID 24480570 DOI: 10.1016/j.jbiotec.2014.01.024  0.96
2014 Dedon PC, Begley TJ. A system of RNA modifications and biased codon use controls cellular stress response at the level of translation. Chemical Research in Toxicology. 27: 330-7. PMID 24422464 DOI: 10.1021/tx400438d  0.96
2014 Mandal D, Köhrer C, Su D, Babu IR, Chan CT, Liu Y, Söll D, Blum P, Kuwahara M, Dedon PC, Rajbhandary UL. Identification and codon reading properties of 5-cyanomethyl uridine, a new modified nucleoside found in the anticodon wobble position of mutant haloarchaeal isoleucine tRNAs. Rna (New York, N.Y.). 20: 177-88. PMID 24344322 DOI: 10.1261/rna.042358.113  0.96
2013 Edrissi B, Taghizadeh K, Moeller BC, Kracko D, Doyle-Eisele M, Swenberg JA, Dedon PC. Dosimetry of N⁶-formyllysine adducts following [¹³C²Hâ‚‚]-formaldehyde exposures in rats. Chemical Research in Toxicology. 26: 1421-3. PMID 24087891 DOI: 10.1021/tx400320u  0.96
2013 Li Y, Chen Q, Zheng D, Yin L, Chionh YH, Wong LH, Tan SQ, Tan TC, Chan JK, Alonso S, Dedon PC, Lim B, Chen J. Induction of functional human macrophages from bone marrow promonocytes by M-CSF in humanized mice. Journal of Immunology (Baltimore, Md. : 1950). 191: 3192-9. PMID 23935193 DOI: 10.4049/jimmunol.1300742  0.96
2013 Mangerich A, Dedon PC, Fox JG, Tannenbaum SR, Wogan GN. Chemistry meets biology in colitis-associated carcinogenesis. Free Radical Research. 47: 958-86. PMID 23926919 DOI: 10.3109/10715762.2013.832239  0.96
2013 Chionh YH, Ho CH, Pruksakorn D, Ramesh Babu I, Ng CS, Hia F, McBee ME, Su D, Pang YL, Gu C, Dong H, Prestwich EG, Shi PY, Preiser PR, Alonso S, ... Dedon PC, et al. A multidimensional platform for the purification of non-coding RNA species. Nucleic Acids Research. 41: e168. PMID 23907385 DOI: 10.1093/nar/gkt668  0.96
2013 Shell SS, Prestwich EG, Baek SH, Shah RR, Sassetti CM, Dedon PC, Fortune SM. DNA methylation impacts gene expression and ensures hypoxic survival of Mycobacterium tuberculosis. Plos Pathogens. 9: e1003419. PMID 23853579 DOI: 10.1371/journal.ppat.1003419  0.96
2013 Knutson CG, Mangerich A, Zeng Y, Raczynski AR, Liberman RG, Kang P, Ye W, Prestwich EG, Lu K, Wishnok JS, Korzenik JR, Wogan GN, Fox JG, Dedon PC, Tannenbaum SR. Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America. 110: E2332-41. PMID 23754421 DOI: 10.1073/pnas.1222669110  0.96
2013 Müller N, Moreno-Villanueva M, Fischbach A, Kienhöfer J, Martello R, Dedon PC, Ullrich V, Bürkle A, Mangerich A. An automated Fpg-based FADU method for the detection of oxidative DNA lesions and screening of antioxidants. Toxicology. 310: 15-21. PMID 23707620 DOI: 10.1016/j.tox.2013.05.006  0.96
2013 Martello R, Mangerich A, Sass S, Dedon PC, Bürkle A. Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics. Acs Chemical Biology. 8: 1567-75. PMID 23631432 DOI: 10.1021/cb400170b  0.96
2013 Prestwich EG, Mangerich A, Pang B, McFaline JL, Lonkar P, Sullivan MR, Trudel LJ, Taghizedeh K, Dedon PC. Increased levels of inosine in a mouse model of inflammation. Chemical Research in Toxicology. 26: 538-46. PMID 23506120 DOI: 10.1021/tx300473n  0.96
2013 Edrissi B, Taghizadeh K, Dedon PC. Quantitative analysis of histone modifications: formaldehyde is a source of pathological n(6)-formyllysine that is refractory to histone deacetylases. Plos Genetics. 9: e1003328. PMID 23468656 DOI: 10.1371/journal.pgen.1003328  0.96
2013 Begley U, Sosa MS, Avivar-Valderas A, Patil A, Endres L, Estrada Y, Chan CT, Su D, Dedon PC, Aguirre-Ghiso JA, Begley T. A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α. Embo Molecular Medicine. 5: 366-83. PMID 23381944 DOI: 10.1002/emmm.201201161  0.96
2013 Cui L, Ye W, Prestwich EG, Wishnok JS, Taghizadeh K, Dedon PC, Tannenbaum SR. Comparative analysis of four oxidized guanine lesions from reactions of DNA with peroxynitrite, singlet oxygen, and γ-radiation. Chemical Research in Toxicology. 26: 195-202. PMID 23140136 DOI: 10.1021/tx300294d  0.96
2012 Lim KS, Cui L, Taghizadeh K, Wishnok JS, Chan W, DeMott MS, Babu IR, Tannenbaum SR, Dedon PC. In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra. Journal of the American Chemical Society. 134: 18053-64. PMID 23057664 DOI: 10.1021/ja307525h  0.96
2012 Wogan GN, Dedon PC, Tannenbaum SR, Fox JG. Infection, inflammation and colon carcinogenesis. Oncotarget. 3: 737-8. PMID 22964519  0.96
2012 Patil A, Dyavaiah M, Joseph F, Rooney JP, Chan CT, Dedon PC, Begley TJ. Increased tRNA modification and gene-specific codon usage regulate cell cycle progression during the DNA damage response. Cell Cycle (Georgetown, Tex.). 11: 3656-65. PMID 22935709 DOI: 10.4161/cc.21919  0.96
2012 Patil A, Chan CT, Dyavaiah M, Rooney JP, Dedon PC, Begley TJ. Translational infidelity-induced protein stress results from a deficiency in Trm9-catalyzed tRNA modifications. Rna Biology. 9: 990-1001. PMID 22832247 DOI: 10.4161/rna.20531  0.96
2012 Chan CT, Pang YL, Deng W, Babu IR, Dyavaiah M, Begley TJ, Dedon PC. Reprogramming of tRNA modifications controls the oxidative stress response by codon-biased translation of proteins. Nature Communications. 3: 937. PMID 22760636 DOI: 10.1038/ncomms1938  0.96
2012 Dendroulakis V, Russell BS, Elmquist CE, Trudel LJ, Wogan GN, Deen WM, Dedon PC. A system for exposing molecules and cells to biologically relevant and accurately controlled steady-state concentrations of nitric oxide and oxygen. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 27: 161-8. PMID 22728703 DOI: 10.1016/j.niox.2012.06.004  0.96
2012 Mangerich A, Knutson CG, Parry NM, Muthupalani S, Ye W, Prestwich E, Cui L, McFaline JL, Mobley M, Ge Z, Taghizadeh K, Wishnok JS, Wogan GN, Fox JG, Tannenbaum SR, ... Dedon PC, et al. Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: E1820-9. PMID 22689960 DOI: 10.1073/pnas.1207829109  0.96
2012 Olipitz W, Wiktor-Brown D, Shuga J, Pang B, McFaline J, Lonkar P, Thomas A, Mutamba JT, Greenberger JS, Samson LD, Dedon PC, Yanch JC, Engelward BP. Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation. Environmental Health Perspectives. 120: 1130-6. PMID 22538203 DOI: 10.1289/ehp.1104294  0.96
2012 Dong H, Chang DC, Hua MH, Lim SP, Chionh YH, Hia F, Lee YH, Kukkaro P, Lok SM, Dedon PC, Shi PY. 2'-O methylation of internal adenosine by flavivirus NS5 methyltransferase. Plos Pathogens. 8: e1002642. PMID 22496660 DOI: 10.1371/journal.ppat.1002642  0.96
2012 Pang B, McFaline JL, Burgis NE, Dong M, Taghizadeh K, Sullivan MR, Elmquist CE, Cunningham RP, Dedon PC. Defects in purine nucleotide metabolism lead to substantial incorporation of xanthine and hypoxanthine into DNA and RNA. Proceedings of the National Academy of Sciences of the United States of America. 109: 2319-24. PMID 22308425 DOI: 10.1073/pnas.1118455109  0.96
2012 Cadet J, Loft S, Olinski R, Evans MD, Bialkowski K, Richard Wagner J, Dedon PC, Møller P, Greenberg MM, Cooke MS. Biologically relevant oxidants and terminology, classification and nomenclature of oxidatively generated damage to nucleobases and 2-deoxyribose in nucleic acids. Free Radical Research. 46: 367-81. PMID 22263561 DOI: 10.3109/10715762.2012.659248  0.96
2012 Lim KS, Taghizadeh K, Wishnok JS, Babu IR, Shafirovich V, Geacintov NE, Dedon PC. Sequence-dependent variation in the reactivity of 8-Oxo-7,8-dihydro-2'-deoxyguanosine toward oxidation. Chemical Research in Toxicology. 25: 366-73. PMID 22103813 DOI: 10.1021/tx200422g  0.96
2011 Mutamba JT, Svilar D, Prasongtanakij S, Wang XH, Lin YC, Dedon PC, Sobol RW, Engelward BP. XRCC1 and base excision repair balance in response to nitric oxide. Dna Repair. 10: 1282-93. PMID 22041025 DOI: 10.1016/j.dnarep.2011.10.008  0.96
2011 Chan CT, Chionh YH, Ho CH, Lim KS, Babu IR, Ang E, Wenwei L, Alonso S, Dedon PC. Identification of N6,N6-dimethyladenosine in transfer RNA from Mycobacterium bovis Bacille Calmette-Guérin. Molecules (Basel, Switzerland). 16: 5168-81. PMID 21694680 DOI: 10.3390/molecules16065168  0.96
2011 Lee YA, Liu Z, Dedon PC, Geacintov NE, Shafirovich V. Solvent exposure associated with single abasic sites alters the base sequence dependence of oxidation of guanine in DNA in GG sequence contexts. Chembiochem : a European Journal of Chemical Biology. 12: 1731-9. PMID 21656632 DOI: 10.1002/cbic.201100140  0.96
2011 Lonkar P, Dedon PC. Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates. International Journal of Cancer. Journal International Du Cancer. 128: 1999-2009. PMID 21387284 DOI: 10.1002/ijc.25815  0.96
2011 Wang L, Chen S, Vergin KL, Giovannoni SJ, Chan SW, DeMott MS, Taghizadeh K, Cordero OX, Cutler M, Timberlake S, Alm EJ, Polz MF, Pinhassi J, Deng Z, Dedon PC. DNA phosphorothioation is widespread and quantized in bacterial genomes. Proceedings of the National Academy of Sciences of the United States of America. 108: 2963-8. PMID 21285367 DOI: 10.1073/pnas.1017261108  0.96
2011 Dedon PC. Oxidation and deamination of DNA by endogenous sources Current Cancer Research. 6: 209-225. DOI: 10.1007/978-1-61737-995-6_10  0.96
2010 Chan SW, Dedon PC. The biological and metabolic fates of endogenous DNA damage products. Journal of Nucleic Acids. 2010: 929047. PMID 21209721 DOI: 10.4061/2010/929047  0.96
2010 Chan CT, Dyavaiah M, DeMott MS, Taghizadeh K, Dedon PC, Begley TJ. A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress. Plos Genetics. 6: e1001247. PMID 21187895 DOI: 10.1371/journal.pgen.1001247  0.96
2010 Yun BH, Dedon PC, Geacintov NE, Shafirovich V. One-electron oxidation of a pyrenyl photosensitizer covalently attached to DNA and competition between its further oxidation and DNA hole injection. Photochemistry and Photobiology. 86: 563-70. PMID 20408978 DOI: 10.1111/j.1751-1097.2010.00719.x  0.96
2010 Chan W, Chen B, Wang L, Taghizadeh K, Demott MS, Dedon PC. Quantification of the 2-deoxyribonolactone and nucleoside 5'-aldehyde products of 2-deoxyribose oxidation in DNA and cells by isotope-dilution gas chromatography mass spectrometry: differential effects of gamma-radiation and Fe2+-EDTA. Journal of the American Chemical Society. 132: 6145-53. PMID 20377226 DOI: 10.1021/ja910928n  0.96
2010 Fu D, Brophy JA, Chan CT, Atmore KA, Begley U, Paules RS, Dedon PC, Begley TJ, Samson LD. Human AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survival. Molecular and Cellular Biology. 30: 2449-59. PMID 20308323 DOI: 10.1128/MCB.01604-09  0.96
2010 Cooke MS, Loft S, Olinski R, Evans MD, Bialkowski K, Wagner JR, Dedon PC, Møller P, Greenberg MM, Cadet J. Recommendations for standardized description of and nomenclature concerning oxidatively damaged nucleobases in DNA. Chemical Research in Toxicology. 23: 705-7. PMID 20235554 DOI: 10.1021/tx1000706  0.96
2010 Margolin Y, Dedon PC. A general method for quantifying sequence effects on nucleobase oxidation in DNA. Methods in Molecular Biology (Clifton, N.J.). 610: 325-40. PMID 20013187 DOI: 10.1007/978-1-60327-029-8_19  0.96
2010 Fox JG, Feng Y, Theve EJ, Raczynski AR, Fiala JL, Doernte AL, Williams M, McFaline JL, Essigmann JM, Schauer DB, Tannenbaum SR, Dedon PC, Weinman SA, Lemon SM, Fry RC, et al. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut. 59: 88-97. PMID 19850960 DOI: 10.1136/gut.2009.183749  0.96
2010 De Mott MS, Dedon PC. Chemistry of Inflammation and DNA Damage: Biological Impact of Reactive Nitrogen Species The Chemical Biology of Dna Damage. 21-51. DOI: 10.1002/9783527630110.ch2  0.96
2010 Prestwich EG, Dedon PC. Endogenous DNA Damage Endogenous Toxins: Targets For Disease Treatment and Prevention. 1-42. DOI: 10.1002/9783527628100.ch1  0.96
2009 Barth M, Dederich D, Dedon P. An improved method for large-scale preparation of negatively and positively supercoiled plasmid DNA. Biotechniques. 47: 633-5. PMID 19594448 DOI: 10.2144/000113172  0.96
2009 Rai P, Onder TT, Young JJ, McFaline JL, Pang B, Dedon PC, Weinberg RA. Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 106: 169-74. PMID 19118192 DOI: 10.1073/pnas.0809834106  0.96
2008 Margolin Y, Shafirovich V, Geacintov NE, DeMott MS, Dedon PC. DNA sequence context as a determinant of the quantity and chemistry of guanine oxidation produced by hydroxyl radicals and one-electron oxidants. The Journal of Biological Chemistry. 283: 35569-78. PMID 18948263 DOI: 10.1074/jbc.M806809200  0.96
2008 Lim CH, Dedon PC, Deen WM. Kinetic analysis of intracellular concentrations of reactive nitrogen species. Chemical Research in Toxicology. 21: 2134-47. PMID 18828639 DOI: 10.1021/tx800213b  0.96
2008 Taghizadeh K, McFaline JL, Pang B, Sullivan M, Dong M, Plummer E, Dedon PC. Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry. Nature Protocols. 3: 1287-98. PMID 18714297 DOI: 10.1038/nprot.2008.119  0.96
2008 Son J, Pang B, McFaline JL, Taghizadeh K, Dedon PC. Surveying the damage: the challenges of developing nucleic acid biomarkers of inflammation. Molecular Biosystems. 4: 902-8. PMID 18704228 DOI: 10.1039/b719411k  0.96
2008 Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD. DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. The Journal of Clinical Investigation. 118: 2516-25. PMID 18521188 DOI: 10.1172/JCI35073  0.96
2008 Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PØ, Klungland A. AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Research. 68: 4142-9. PMID 18519673 DOI: 10.1158/0008-5472.CAN-08-0796  0.96
2008 Lee YA, Durandin A, Dedon PC, Geacintov NE, Shafirovich V. Oxidation of guanine in G, GG, and GGG sequence contexts by aromatic pyrenyl radical cations and carbonate radical anions: relationship between kinetics and distribution of alkali-labile lesions. The Journal of Physical Chemistry. B. 112: 1834-44. PMID 18211057 DOI: 10.1021/jp076777x  0.96
2008 Dedon PC. The chemical toxicology of 2-deoxyribose oxidation in DNA. Chemical Research in Toxicology. 21: 206-19. PMID 18052112 DOI: 10.1021/tx700283c  0.96
2007 Chen B, Zhou X, Taghizadeh K, Chen J, Stubbe J, Dedon PC. GC/MS methods to quantify the 2-deoxypentos-4-ulose and 3'-phosphoglycolate pathways of 4' oxidation of 2-deoxyribose in DNA: application to DNA damage produced by gamma radiation and bleomycin. Chemical Research in Toxicology. 20: 1701-8. PMID 17944541 DOI: 10.1021/tx700164y  0.96
2007 Wang L, Chen S, Xu T, Taghizadeh K, Wishnok JS, Zhou X, You D, Deng Z, Dedon PC. Phosphorothioation of DNA in bacteria by dnd genes. Nature Chemical Biology. 3: 709-10. PMID 17934475 DOI: 10.1038/nchembio.2007.39  0.96
2007 Kim MY, Zhou X, Delaney JC, Taghizadeh K, Dedon PC, Essigmann JM, Wogan GN. AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector. Chemical Research in Toxicology. 20: 1075-83. PMID 17658757 DOI: 10.1021/tx700167v  0.96
2007 Yun BH, Lee YA, Kim SK, Kuzmin V, Kolbanovskiy A, Dedon PC, Geacintov NE, Shafirovich V. Photosensitized oxidative DNA damage: from hole injection to chemical product formation and strand cleavage. Journal of the American Chemical Society. 129: 9321-32. PMID 17616188 DOI: 10.1021/ja066954s  0.96
2007 Pang B, Zhou X, Yu H, Dong M, Taghizadeh K, Wishnok JS, Tannenbaum SR, Dedon PC. Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation. Carcinogenesis. 28: 1807-13. PMID 17347141 DOI: 10.1093/carcin/bgm037  0.96
2007 Lee YA, Yun BH, Kim SK, Margolin Y, Dedon PC, Geacintov NE, Shafirovich V. Mechanisms of oxidation of guanine in DNA by carbonate radical anion, a decomposition product of nitrosoperoxycarbonate. Chemistry (Weinheim An Der Bergstrasse, Germany). 13: 4571-81. PMID 17335089 DOI: 10.1002/chem.200601434  0.96
2007 Jiang T, Zhou X, Taghizadeh K, Dong M, Dedon PC. N-formylation of lysine in histone proteins as a secondary modification arising from oxidative DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 104: 60-5. PMID 17190813 DOI: 10.1073/pnas.0606775103  0.96
2006 Fry RC, DeMott MS, Cosgrove JP, Begley TJ, Samson LD, Dedon PC. The DNA-damage signature in Saccharomyces cerevisiae is associated with single-strand breaks in DNA. Bmc Genomics. 7: 313. PMID 17163986 DOI: 10.1186/1471-2164-7-313  0.96
2006 Reiter TA, Pang B, Dedon P, Demple B. Resistance to nitric oxide-induced necrosis in heme oxygenase-1 overexpressing pulmonary epithelial cells associated with decreased lipid peroxidation. The Journal of Biological Chemistry. 281: 36603-12. PMID 17020887 DOI: 10.1074/jbc.M602634200  0.96
2006 Zipes DP, Zvaifler NJ, Glassock RJ, Gilman S, Muñoz A, Gogolak V, Gordis L, Dedon PC, Guengerich FP, Wasserman SI, Witztum JL, Wogan GN. Rosuvastatin: an independent analysis of risks and benefits. Medgenmed : Medscape General Medicine. 8: 73. PMID 16926812  0.96
2006 Chen B, Vu CC, Byrns MC, Dedon PC, Peterson LA. Formation of 1,4-dioxo-2-butene-derived adducts of 2'-deoxyadenosine and 2'-deoxycytidine in oxidized DNA. Chemical Research in Toxicology. 19: 982-5. PMID 16918236 DOI: 10.1021/tx0601197  0.96
2006 Margolin Y, Cloutier JF, Shafirovich V, Geacintov NE, Dedon PC. Paradoxical hotspots for guanine oxidation by a chemical mediator of inflammation. Nature Chemical Biology. 2: 365-6. PMID 16751762 DOI: 10.1038/nchembio796  0.96
2006 Li CQ, Pang B, Kiziltepe T, Trudel LJ, Engelward BP, Dedon PC, Wogan GN. Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells. Chemical Research in Toxicology. 19: 399-406. PMID 16544944 DOI: 10.1021/tx050283e  0.96
2006 Dong M, Dedon PC. Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide. Chemical Research in Toxicology. 19: 50-7. PMID 16411656 DOI: 10.1021/tx050252j  0.96
2006 Dong M, Vongchampa V, Gingipalli L, Cloutier JF, Kow YW, O'Connor T, Dedon PC. Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species. Mutation Research. 594: 120-34. PMID 16274707 DOI: 10.1016/j.mrfmmm.2005.08.008  0.96
2006 Dedon PC, Barth M, Chen B, De Mott M, Dendroulakis V, Dong M, Kalinga S, Elmquist E, Margolin Y, Pang B, Zhou X. Chapter 2 Diverse Mechanisms of Endogenous Nucleobase Deamination in DNA and RNA Advances in Molecular Toxicology. 1: 25-63. DOI: 10.1016/S1872-0854(06)01002-2  0.96
2005 Li CQ, Wright TL, Dong M, Dommels YE, Trudel LJ, Dedon PC, Tannenbaum SR, Wogan GN. Biological role of glutathione in nitric oxide-induced toxicity in cell culture and animal models. Free Radical Biology & Medicine. 39: 1489-98. PMID 16274884 DOI: 10.1016/j.freeradbiomed.2005.07.011  0.96
2005 Zhou X, Liberman RG, Skipper PL, Margolin Y, Tannenbaum SR, Dedon PC. Quantification of DNA strand breaks and abasic sites by oxime derivatization and accelerator mass spectrometry: application to gamma-radiation and peroxynitrite. Analytical Biochemistry. 343: 84-92. PMID 15964542 DOI: 10.1016/j.ab.2005.05.007  0.96
2005 Collins C, Zhou X, Wang R, Barth MC, Jiang T, Coderre JA, Dedon PC. Differential oxidation of deoxyribose in DNA by gamma and alpha-particle radiation. Radiation Research. 163: 654-62. PMID 15913397 DOI: 10.1667/RR3344  0.96
2005 Zhou X, Taghizadeh K, Dedon PC. Chemical and biological evidence for base propenals as the major source of the endogenous M1dG adduct in cellular DNA. The Journal of Biological Chemistry. 280: 25377-82. PMID 15878883 DOI: 10.1074/jbc.M503079200  0.96
2005 Kiziltepe T, Yan A, Dong M, Jonnalagadda VS, Dedon PC, Engelward BP. Delineation of the chemical pathways underlying nitric oxide-induced homologous recombination in mammalian cells. Chemistry & Biology. 12: 357-69. PMID 15797220 DOI: 10.1016/j.chembiol.2004.12.011  0.96
2005 Kim MY, Dong M, Dedon PC, Wogan GN. Effects of peroxynitrite dose and dose rate on DNA damage and mutation in the supF shuttle vector. Chemical Research in Toxicology. 18: 76-86. PMID 15651852 DOI: 10.1021/tx049777m  0.96
2004 Chen B, Bohnert T, Zhou X, Dedon PC. 5'-(2-phosphoryl-1,4-dioxobutane) as a product of 5'-oxidation of deoxyribose in DNA: elimination as trans-1,4-dioxo-2-butene and approaches to analysis. Chemical Research in Toxicology. 17: 1406-13. PMID 15540938 DOI: 10.1021/tx049818e  0.96
2004 Bohnert T, Gingipalli L, Dedon PC. Reaction of 2'-deoxyribonucleosides with cis- and trans-1,4-dioxo-2-butene. Biochemical and Biophysical Research Communications. 323: 838-44. PMID 15381076 DOI: 10.1016/j.bbrc.2004.08.164  0.96
2004 Dedon PC, Tannenbaum SR. Reactive nitrogen species in the chemical biology of inflammation. Archives of Biochemistry and Biophysics. 423: 12-22. PMID 14989259 DOI: 10.1016/j.abb.2003.12.017  0.96
2003 Collins C, Awada MM, Zhou X, Dedon PC. Analysis of 3'-phosphoglycolaldehyde residues in oxidized DNA by gas chromatography/negative chemical ionization/mass spectrometry. Chemical Research in Toxicology. 16: 1560-6. PMID 14680370 DOI: 10.1021/tx0341198  0.96
2003 Dong M, Wang C, Deen WM, Dedon PC. Absence of 2'-deoxyoxanosine and presence of abasic sites in DNA exposed to nitric oxide at controlled physiological concentrations. Chemical Research in Toxicology. 16: 1044-55. PMID 12971791 DOI: 10.1021/tx034046s  0.96
2003 Vongchampa V, Dong M, Gingipalli L, Dedon P. Stability of 2'-deoxyxanthosine in DNA. Nucleic Acids Research. 31: 1045-51. PMID 12560502 DOI: 10.1093/nar/gkg177  0.96
2002 Plastaras JP, Dedon PC, Marnett LJ. Effects of DNA structure on oxopropenylation by the endogenous mutagens malondialdehyde and base propenal. Biochemistry. 41: 5033-42. PMID 11939800 DOI: 10.1021/bi0113059  0.96
2001 Dedon PC. Determination of binding mode: intercalation. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 8.1. PMID 18428878 DOI: 10.1002/0471142700.nc0801s00  0.96
2001 Awada M, Dedon PC. Analysis of oxidized DNA fragments by gel electrophoresis. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 10.8. PMID 18428827 DOI: 10.1002/0471142700.nc1008s04  0.96
2001 Awada M, Dedon PC. Formation of the 1,N2-glyoxal adduct of deoxyguanosine by phosphoglycolaldehyde, a product of 3'-deoxyribose oxidation in DNA. Chemical Research in Toxicology. 14: 1247-53. PMID 11559039 DOI: 10.1021/tx0155092  0.96
2001 Gingipalli L, Dedon PC. Reaction of cis- and trans-2-Butene-1,4-dial with 2'-deoxycytidine to form stable oxadiazabicyclooctaimine adducts. Journal of the American Chemical Society. 123: 2664-5. PMID 11456937 DOI: 10.1021/ja0056421  0.96
2001 Lopez-Larraza DM, Moore K, Dedon PC. Thiols alter the partitioning of calicheamicin-induced deoxyribose 4'-oxidation reactions in the absence of DNA radical repair. Chemical Research in Toxicology. 14: 528-35. PMID 11368551 DOI: 10.1021/tx0100082  0.96
2001 Liang Q, Dedon PC. Cu(II)/H2O2-induced DNA damage is enhanced by packaging of DNA as a nucleosome. Chemical Research in Toxicology. 14: 416-22. PMID 11304130 DOI: 10.1021/tx0002278  0.96
2000 Salzberg AA, Dedon PC. DNA bending is a determinant of calicheamicin target recognition. Biochemistry. 39: 7605-12. PMID 10858311 DOI: 10.1021/bi992227g  0.96
2000 Tretyakova NY, Burney S, Pamir B, Wishnok JS, Dedon PC, Wogan GN, Tannenbaum SR. Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum. Mutation Research. 447: 287-303. PMID 10751613 DOI: 10.1016/S0027-5107(99)00221-3  0.96
2000 Michejda CJ, Dedon PC, Marnett LJ. Highlights from a symposium on the Mechanisms of Action of Cytotoxic Agents Chemical Research in Toxicology. 13: 933-935. DOI: 10.1021/tx000496y  0.96
1999 Wu J, Xu J, Dedon PC. Modulation of enediyne-induced DNA damage by chromatin structures in transcriptionally active genes Biochemistry. 38: 15641-15646. PMID 10569949 DOI: 10.1021/bi991999+  0.96
1999 Burney S, Niles JC, Dedon PC, Tannenbaum SR. DNA damage in deoxynucleosides and oligonucleotides treated with peroxynitrite Chemical Research in Toxicology. 12: 513-520. PMID 10368314 DOI: 10.1021/tx980254m  0.96
1999 Chaudhry MA, Dedon PC, Wilson DM, Demple B, Weinfeld M. Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and γ-radiation Biochemical Pharmacology. 57: 531-538. PMID 9952316 DOI: 10.1016/S0006-2952(98)00327-X  0.96
1999 Jones WR, Dedon PC. DNA oxidation as a source of endogenous electrophiles: Formation of ethenoadenine adducts in γ-irradiated DNA [7] Journal of the American Chemical Society. 121: 9231-9232. DOI: 10.1021/ja991517h  0.96
1998 Dedon PC, Plastaras JP, Rouzer CA, Marnett LJ. Indirect mutagenesis by oxidative DNA damage: Formation of the pyrimidopurinone adduct of deoxyguanosine by base propenal Proceedings of the National Academy of Sciences of the United States of America. 95: 11113-11116. PMID 9736698 DOI: 10.1073/pnas.95.19.11113  0.96
1998 Xu J, Wu J, Dedon PC. DNA damage produced by enediynes in the human phosphoglycerate kinase gene in vivo: Esperamicin A1 as a nucleosome footprinting agent Biochemistry. 37: 1890-1897. PMID 9485314 DOI: 10.1021/bi972508t  0.96
1998 Lamarr WA, Yu L, Nicolaou KC, Dedon PC. Supercoiling affects the accessibility of glutathione to DNA-bound molecules: Positive supercoiling inhibits calicheamicin-induced DNA damage Proceedings of the National Academy of Sciences of the United States of America. 95: 102-107. PMID 9419336 DOI: 10.1073/pnas.95.1.102  0.96
1997 Salzberg AA, Dedon PC. An improved method for the rapid assessment of DNA bending by small molecules. Journal of Biomolecular Structure & Dynamics. 15: 277-84. PMID 9399155 DOI: 10.1080/07391102.1997.10508192  0.96
1997 Mathur P, Xu J, Dedon PC. Cytosine methylation enhances DNA damage produced by groove binding and intercalating enediynes: Studies with esperamicins A1 and C Biochemistry. 36: 14868-14873. PMID 9398209 DOI: 10.1021/bi971533w  0.96
1997 Liang Q, Choi DJ, Dedon PC. Calicheamicin-mediated DNA damage in a reconstituted nucleosome is not affected by histone acetylation: The role of drug structure in the target recognition process Biochemistry. 36: 12653-12659. PMID 9376372 DOI: 10.1021/bi9718393  0.96
1997 LaMarr WA, Sandman KM, Reeve JN, Dedon PC. Differential effects of DNA supercoiling on radical-mediated DNA strand breaks Chemical Research in Toxicology. 10: 1118-1122. PMID 9348434 DOI: 10.1021/tx970072c  0.96
1997 Kennedy LJ, Moore K, Caulfield JL, Tannenbaum SR, Dedon PC. Quantitation of 8-oxoguanine and strand breaks produced by four oxidizing agents Chemical Research in Toxicology. 10: 386-392. PMID 9114974 DOI: 10.1021/tx960102w  0.96
1997 LaMarr WA, Sandman KM, Reeve JN, Dedon PC. Large scale preparation of positively supercoiled DNA using the archaeal histone HMf Nucleic Acids Research. 25: 1660-1661. PMID 9092677 DOI: 10.1093/nar/25.8.1660  0.96
1997 Plastaras JP, Roujer CA, Marnett LJ, Dedon PC. Formation of malondialdehyde-deoxyguanosine adduct by base propenal, a byproduct of DNA strand scission by 4' hydrogen abstraction Faseb Journal. 11: A1369.  0.96
1996 Dedon PC. Mechanisms of target selection by DNA-damaging chemicals: Studies with enediyne anticancer drugs International Archives of Occupational and Environmental Health. 68: 408-414. PMID 8891777 DOI: 10.1007/s004200050085  0.96
1995 Yu L, Salzberg AA, Dedon PC. New insights into calicheamicin-DNA interactions derived from a model nucleosome system. Bioorganic & Medicinal Chemistry. 3: 729-41. PMID 7582951 DOI: 10.1016/0968-0896(95)00054-K  0.96
1995 Yu L, Mah S, Otani T, Dedon P. The benzoxazolinate of C-1027 confers intercalative DNA binding Journal of the American Chemical Society. 117: 8877-8878. DOI: 10.1021/ja00139a032  0.96
1994 Yu L, Goldberg IH, Dedon PC. Enediyne-mediated DNA damage in nuclei is modulated at the level of the nucleosome Journal of Biological Chemistry. 269: 4144-4151. PMID 8307975  0.96
1994 Yu L, Golik J, Harrison R, Dedon P. The deoxyfucose-anthranilate of esperamicin A1 confers intercalative DNA binding and causes a switch in the chemistry of bistranded DNA lesions Journal of the American Chemical Society. 116: 9733-9738. DOI: 10.1021/ja00100a044  0.96
1994 Ikemoto N, Kumar RA, Dedon PC, Danishefsky SJ, Patel DJ. Esperamicin A1 intercalates into duplex DNA from the minor groove Journal of the American Chemical Society. 116: 9387-9388. DOI: 10.1021/ja00099a089  0.96
1993 Dedon PC, Salzberg AA, Xu J. Exclusive production of bistranded DNA damage by calicheamicin. Biochemistry. 32: 3617-22. PMID 8466904  0.96
1993 Stargell LA, Bowen J, Dadd CA, Dedon PC, Davis M, Cook RG, Allis CD, Gorovsky MA. Temporal and spatial association of histone H2A variant hv1 with transcriptionally competent chromatin during nuclear development in Tetrahymena thermophila. Genes & Development. 7: 2641-51. PMID 8276246  0.96
1992 Dedon PC, Jiang ZW, Goldberg IH. Neocarzinostatin-mediated DNA damage in a model AGT·ACT site: Mechanistic studies of thiol-sensitive partitioning of C4′ DNA damage products Biochemistry®. 31: 1917-1927. PMID 1531616  0.96
1992 Dedon PC, Goldberg IH. Influence of thiol structure on neocarzinostatin activation and expression of DNA damage Biochemistry®. 31: 1909-1917. PMID 1531615  0.96
1992 Dedon PC, Goldberg IH. Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin Chemical Research in Toxicology. 5: 311-332. PMID 1380322  0.96
1991 Dedon PC, Soults JA, Allis CD, Gorovsky MA. Formaldehyde cross-linking and immunoprecipitation demonstrate developmental changes in H1 association with transcriptionally active genes. Molecular and Cellular Biology. 11: 1729-33. PMID 1996118  0.96
1991 Dedon PC, Soults JA, Allis CD, Gorovsky MA. A simplified formaldehyde fixation and immunoprecipitation technique for studying protein-DNA interactions. Analytical Biochemistry. 197: 83-90. PMID 1952079 DOI: 10.1016/0003-2697(91)90359-2  0.96
1990 Dedon PC, Goldberg IH. Sequence-specific double-strand breakage of DNA by neocarzinostatin involves different chemical mechanisms within a staggered cleavage site Journal of Biological Chemistry. 265: 14713-14716. PMID 2144279  0.96
1988 Qazi R, Chang AY, Borch RF, Montine T, Dedon P, Loughner J, Bennett JM. Phase I clinical and pharmacokinetic study of diethyldithiocarbamate as a chemoprotector from toxic effects of cisplatin. Journal of the National Cancer Institute. 80: 1486-8. PMID 2846857 DOI: 10.1093/jnci/80.18.1486  0.96
1987 Dedon PC, Borch RF. Characterization of the reactions of platinum antitumor agents with biologic and nonbiologic sulfur-containing nucleophiles. Biochemical Pharmacology. 36: 1955-64. PMID 2954556 DOI: 10.1016/0006-2952(87)90494-1  0.96
1986 Bodenner DL, Dedon PC, Keng PC, Katz JC, Borch RF. Selective protection against cis-diamminedichloroplatinum(II)-induced toxicity in kidney, gut, and bone marrow by diethyldithiocarbamate. Cancer Research. 46: 2751-5. PMID 3009000  0.96
1986 Bodenner DL, Dedon PC, Keng PC, Borch RF. Effect of diethyldithiocarbamate on cis-diamminedichloroplatinum(II)-induced cytotoxicity, DNA cross-linking, and gamma-glutamyl transpeptidase inhibition. Cancer Research. 46: 2745-50. PMID 2870800  0.96
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