Randal J. Kaufman - Publications

Affiliations: 
University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Biochemistry, Cell Biology

188 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Li H, O'Meara M, Zhang X, Zhang K, Seyoum B, Yi Z, Kaufman RJ, Monks TJ, Wang JM. Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes. Diabetes. PMID 30885990 DOI: 10.2337/db18-0933  0.44
2018 Wang JM, Qiu Y, Yang Z, Kim H, Qian Q, Sun Q, Zhang C, Yin L, Fang D, Back SH, Kaufman RJ, Yang L, Zhang K. IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs. Science Signaling. 11. PMID 29764990 DOI: 10.1126/scisignal.aao4617  0.44
2017 Chandrahas VK, Han J, Kaufman RJ. Coordinating Organismal Metabolism During Protein Misfolding in the ER Through the Unfolded Protein Response. Current Topics in Microbiology and Immunology. PMID 28900680 DOI: 10.1007/82_2017_41  0.4
2017 Han J, Kaufman RJ. Physiological/pathological ramifications of transcription factors in the unfolded protein response. Genes & Development. 31: 1417-1438. PMID 28860159 DOI: 10.1101/gad.297374.117  0.4
2017 Choi WG, Han J, Kim JH, Kim MJ, Park JW, Song B, Cha HJ, Choi HS, Chung HT, Lee IK, Park TS, Hatzoglou M, Choi HS, Yoo HJ, Kaufman RJ, et al. eIF2α phosphorylation is required to prevent hepatocyte death and liver fibrosis in mice challenged with a high fructose diet. Nutrition & Metabolism. 14: 48. PMID 28781602 DOI: 10.1186/s12986-017-0202-6  0.4
2017 DeZwaan-McCabe D, Sheldon RD, Gorecki MC, Guo DF, Gansemer ER, Kaufman RJ, Rahmouni K, Gillum MP, Taylor EB, Teesch LM, Rutkowski DT. ER Stress Inhibits Liver Fatty Acid Oxidation while Unmitigated Stress Leads to Anorexia-Induced Lipolysis and Both Liver and Kidney Steatosis. Cell Reports. 19: 1794-1806. PMID 28564599 DOI: 10.1016/j.celrep.2017.05.020  0.32
2016 Han J, Kaufman RJ. The role of ER stress in lipid metabolism and lipotoxicity. Journal of Lipid Research. PMID 27146479 DOI: 10.1194/jlr.R067595  0.4
2015 Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, Bai Y, Sartor M, Cavalcoli J, Malhi H, Baudouin G, ... ... Kaufman RJ, et al. The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells. Plos Biology. 13: e1002277. PMID 26469762 DOI: 10.1371/journal.pbio.1002277  0.4
2015 Zhou AX, Wang X, Lin CS, Han J, Yong J, Nadolski MJ, Borén J, Kaufman RJ, Tabas I. C/EBP-Homologous Protein (CHOP) in Vascular Smooth Muscle Cells Regulates Their Proliferation in Aortic Explants and Atherosclerotic Lesions. Circulation Research. 116: 1736-43. PMID 25872946 DOI: 10.1161/CIRCRESAHA.116.305602  0.4
2015 Han J, Song B, Kim J, Kodali VK, Pottekat A, Wang M, Hassler J, Wang S, Pennathur S, Back SH, Katze MG, Kaufman RJ. Antioxidants complement the requirement for protein chaperone function to maintain beta cell function and glucose homeostasis. Diabetes. PMID 25795214 DOI: 10.2337/db14-1357  0.4
2015 Wang S, Park S, Kodali VK, Han J, Yip T, Chen Z, Davidson NO, Kaufman RJ. Identification of protein disulfide isomerase 1 as a key isomerase for disulfide bond formation in apolipoprotein B100. Molecular Biology of the Cell. 26: 594-604. PMID 25518935 DOI: 10.1091/mbc.E14-08-1274  0.44
2015 Xi Y, Garshott DM, Brownell AL, Yoo GH, Lin HS, Freeburg TL, Yoo NG, Kaufman RJ, Callaghan MU, Fribley AM. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. Journal of Dental Research. 94: 320-9. PMID 25425581 DOI: 10.1177/0022034514559376  0.44
2015 Javeed N, Sagar G, Dutta SK, Smyrk TC, Lau JS, Bhattacharya S, Truty M, Petersen GM, Kaufman RJ, Chari ST, Mukhopadhyay D. Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic β-cell Dysfunction. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 1722-33. PMID 25355928 DOI: 10.1158/1078-0432.CCR-14-2022  0.44
2014 Yong J, Grankvist N, Han J, Kaufman RJ. Eukaryotic translation initiation factor 2 α phosphorylation as a therapeutic target in diabetes. Expert Review of Endocrinology & Metabolism. 9: 345-356. PMID 30763994 DOI: 10.1586/17446651.2014.927309  0.4
2014 Flaherty DP, Miller JR, Garshott DM, Hedrick M, Gosalia P, Li Y, Milewski M, Sugarman E, Vasile S, Salaniwal S, Su Y, Smith LH, Chung TD, Pinkerton AB, Aubé J, ... ... Kaufman RJ, et al. Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response. Acs Medicinal Chemistry Letters. 5: 1278-1283. PMID 25530830 DOI: 10.1021/ml5003234  0.44
2014 Wang M, Kaufman RJ. The impact of the endoplasmic reticulum protein-folding environment on cancer development. Nature Reviews. Cancer. 14: 581-97. PMID 25145482 DOI: 10.1038/nrc3800  0.44
2014 Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT, Péterfy M. Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling. The Journal of Biological Chemistry. 289: 24417-27. PMID 25035425 DOI: 10.1074/jbc.M114.588764  0.44
2014 Sadleir KR, Eimer WA, Kaufman RJ, Osten P, Vassar R. Genetic inhibition of phosphorylation of the translation initiation factor eIF2α does not block Aβ-dependent elevation of BACE1 and APP levels or reduce amyloid pathology in a mouse model of Alzheimer's disease. Plos One. 9: e101643. PMID 24992504 DOI: 10.1371/journal.pone.0101643  0.44
2014 Bai Y, Hassler J, Ziyar A, Li P, Wright Z, Menon R, Omenn GS, Cavalcoli JD, Kaufman RJ, Sartor MA. Novel bioinformatics method for identification of genome-wide non-canonical spliced regions using RNA-Seq data. Plos One. 9: e100864. PMID 24991935 DOI: 10.1371/journal.pone.0100864  0.44
2014 Di Prisco GV, Huang W, Buffington SA, Hsu CC, Bonnen PE, Placzek AN, Sidrauski C, Krnjević K, Kaufman RJ, Walter P, Costa-Mattioli M. Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α. Nature Neuroscience. 17: 1073-82. PMID 24974795 DOI: 10.1038/nn.3754  0.44
2014 Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, Kim do H, Baretta K, Srikanth S, Gwack Y, Ahnn J, ... Kaufman RJ, et al. Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Science Signaling. 7: ra54. PMID 24917591 DOI: 10.1126/scisignal.2004983  0.44
2014 Scortegagna M, Kim H, Li JL, Yao H, Brill LM, Han J, Lau E, Bowtell D, Haddad G, Kaufman RJ, Ronai ZA. Fine tuning of the UPR by the ubiquitin ligases Siah1/2. Plos Genetics. 10: e1004348. PMID 24809345 DOI: 10.1371/journal.pgen.1004348  0.44
2014 Cao SS, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxidants & Redox Signaling. 21: 396-413. PMID 24702237 DOI: 10.1089/ars.2014.5851  0.44
2014 Kaufman RJ, Malhotra JD. Calcium trafficking integrates endoplasmic reticulum function with mitochondrial bioenergetics. Biochimica Et Biophysica Acta. 1843: 2233-9. PMID 24690484 DOI: 10.1016/j.bbamcr.2014.03.022  0.44
2014 Hiramatsu N, Messah C, Han J, LaVail MM, Kaufman RJ, Lin JH. Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response. Molecular Biology of the Cell. 25: 1411-20. PMID 24623724 DOI: 10.1091/mbc.E13-11-0664  0.44
2014 Ferris SP, Kodali VK, Kaufman RJ. Glycoprotein folding and quality-control mechanisms in protein-folding diseases. Disease Models & Mechanisms. 7: 331-41. PMID 24609034 DOI: 10.1242/dmm.014589  0.44
2014 Cao SS, Wang M, Harrington JC, Chuang BM, Eckmann L, Kaufman RJ. Phosphorylation of eIF2α is dispensable for differentiation but required at a posttranscriptional level for paneth cell function and intestinal homeostasis in mice. Inflammatory Bowel Diseases. 20: 712-22. PMID 24577114 DOI: 10.1097/MIB.0000000000000010  0.44
2014 Wang S, Kaufman RJ. How does protein misfolding in the endoplasmic reticulum affect lipid metabolism in the liver? Current Opinion in Lipidology. 25: 125-32. PMID 24565920 DOI: 10.1097/MOL.0000000000000056  0.44
2014 Han J, Kaufman RJ. Measurement of the unfolded protein response to investigate its role in adipogenesis and obesity. Methods in Enzymology. 538: 135-50. PMID 24529437 DOI: 10.1016/B978-0-12-800280-3.00008-6  0.44
2014 Yong J, Grankvist N, Han J, Kaufman RJ. Eukaryotic translation initiation factor 2 α phosphorylation as a therapeutic target in diabetes Expert Review of Endocrinology and Metabolism. 9: 345-356. DOI: 10.1586/17446651.2014.927309  0.44
2013 Rajesh K, Papadakis AI, Kazimierczak U, Peidis P, Wang S, Ferbeyre G, Kaufman RJ, Koromilas AE. eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies. Aging. 5: 884-901. PMID 24334569  0.44
2013 Arensdorf AM, Dezwaan McCabe D, Kaufman RJ, Rutkowski DT. Temporal clustering of gene expression links the metabolic transcription factor HNF4α to the ER stress-dependent gene regulatory network. Frontiers in Genetics. 4: 188. PMID 24069029 DOI: 10.3389/fgene.2013.00188  0.44
2013 Sakaki K, Kaufman RJ. Interaction between quality control systems for ER protein folding and RNA biogenesis. Worm. 2: e23005. PMID 24058870 DOI: 10.4161/worm.23005  0.48
2013 Qiu Q, Zheng Z, Chang L, Zhao YS, Tan C, Dandekar A, Zhang Z, Lin Z, Gui M, Li X, Zhang T, Kong Q, Li H, Chen S, Chen A, ... Kaufman RJ, et al. Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis. The Embo Journal. 32: 2477-90. PMID 23942232 DOI: 10.1038/emboj.2013.183  0.44
2013 Ferris SP, Jaber NS, Molinari M, Arvan P, Kaufman RJ. UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum. Molecular Biology of the Cell. 24: 2597-608. PMID 23864712 DOI: 10.1091/mbc.E13-02-0101  0.44
2013 Landau G, Kodali VK, Malhotra JD, Kaufman RJ. Detection of oxidative damage in response to protein misfolding in the endoplasmic reticulum. Methods in Enzymology. 526: 231-50. PMID 23791104 DOI: 10.1016/B978-0-12-405883-5.00014-4  0.44
2013 Malhi H, Kropp EM, Clavo VF, Kobrossi CR, Han J, Mauer AS, Yong J, Kaufman RJ. C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. The Journal of Biological Chemistry. 288: 18624-42. PMID 23720735 DOI: 10.1074/jbc.M112.442954  0.44
2013 Misra J, Kim DK, Choi W, Koo SH, Lee CH, Back SH, Kaufman RJ, Choi HS. Transcriptional cross talk between orphan nuclear receptor ERRγ and transmembrane transcription factor ATF6α coordinates endoplasmic reticulum stress response. Nucleic Acids Research. 41: 6960-74. PMID 23716639 DOI: 10.1093/nar/gkt429  0.44
2013 Krokowski D, Han J, Saikia M, Majumder M, Yuan CL, Guan BJ, Bevilacqua E, Bussolati O, Bröer S, Arvan P, Tchórzewski M, Snider MD, Puchowicz M, Croniger CM, Kimball SR, ... ... Kaufman RJ, et al. A self-defeating anabolic program leads to β-cell apoptosis in endoplasmic reticulum stress-induced diabetes via regulation of amino acid flux. The Journal of Biological Chemistry. 288: 17202-13. PMID 23645676 DOI: 10.1074/jbc.M113.466920  0.44
2013 Han J, Back SH, Hur J, Lin YH, Gildersleeve R, Shan J, Yuan CL, Krokowski D, Wang S, Hatzoglou M, Kilberg MS, Sartor MA, Kaufman RJ. ER-stress-induced transcriptional regulation increases protein synthesis leading to cell death. Nature Cell Biology. 15: 481-90. PMID 23624402 DOI: 10.1038/ncb2738  0.44
2013 Binet F, Mawambo G, Sitaras N, Tetreault N, Lapalme E, Favret S, Cerani A, Leboeuf D, Tremblay S, Rezende F, Juan AM, Stahl A, Joyal JS, Milot E, Kaufman RJ, et al. Neuronal ER stress impedes myeloid-cell-induced vascular regeneration through IRE1α degradation of netrin-1. Cell Metabolism. 17: 353-71. PMID 23473031 DOI: 10.1016/j.cmet.2013.02.003  0.44
2013 Cao SS, Zimmermann EM, Chuang BM, Song B, Nwokoye A, Wilkinson JE, Eaton KA, Kaufman RJ. The unfolded protein response and chemical chaperones reduce protein misfolding and colitis in mice. Gastroenterology. 144: 989-1000.e6. PMID 23336977 DOI: 10.1053/j.gastro.2013.01.023  0.44
2013 Cao SS, Kaufman RJ. Targeting endoplasmic reticulum stress in metabolic disease. Expert Opinion On Therapeutic Targets. 17: 437-48. PMID 23324104 DOI: 10.1517/14728222.2013.756471  0.44
2013 Han J, Murthy R, Wood B, Song B, Wang S, Sun B, Malhi H, Kaufman RJ. ER stress signalling through eIF2α and CHOP, but not IRE1α, attenuates adipogenesis in mice. Diabetologia. 56: 911-24. PMID 23314846 DOI: 10.1007/s00125-012-2809-5  0.44
2013 Cao SS, Kaufman RJ. PKR in DSS-induced colitis: a matter of genetic background and maternal microflora? Inflammatory Bowel Diseases. 19: E49-50. PMID 22508268 DOI: 10.1002/ibd.22978  0.44
2012 Hassler J, Cao SS, Kaufman RJ. IRE1, a double-edged sword in pre-miRNA slicing and cell death. Developmental Cell. 23: 921-3. PMID 23153490 DOI: 10.1016/j.devcel.2012.10.025  0.44
2012 Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO, Kaufman RJ. IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis. Cell Metabolism. 16: 473-86. PMID 23040069 DOI: 10.1016/j.cmet.2012.09.003  0.44
2012 Cao SS, Kaufman RJ. Unfolded protein response. Current Biology : Cb. 22: R622-6. PMID 22917505 DOI: 10.1016/j.cub.2012.07.004  0.44
2012 Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, Greiner D, Kaufman RJ, Bortell R, Urano F. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome. Cell Metabolism. 16: 265-73. PMID 22883234 DOI: 10.1016/j.cmet.2012.07.005  0.44
2012 Wang S, Kaufman RJ. The impact of the unfolded protein response on human disease. The Journal of Cell Biology. 197: 857-67. PMID 22733998 DOI: 10.1083/jcb.201110131  0.44
2012 Yung HW, Hemberger M, Watson ED, Senner CE, Jones CP, Kaufman RJ, Charnock-Jones DS, Burton GJ. Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction. The Journal of Pathology. 228: 554-64. PMID 22733590 DOI: 10.1002/path.4068  0.44
2012 Gilbert GE, Novakovic VA, Kaufman RJ, Miao H, Pipe SW. Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity. Blood. 120: 1923-32. PMID 22613792 DOI: 10.1182/blood-2012-01-408245  0.44
2012 Sakaki K, Yoshina S, Shen X, Han J, DeSantis MR, Xiong M, Mitani S, Kaufman RJ. RNA surveillance is required for endoplasmic reticulum homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 109: 8079-84. PMID 22562797 DOI: 10.1073/pnas.1110589109  0.44
2012 Back SH, Kaufman RJ. Endoplasmic reticulum stress and type 2 diabetes. Annual Review of Biochemistry. 81: 767-93. PMID 22443930 DOI: 10.1146/annurev-biochem-072909-095555  0.44
2012 Cao SS, Song B, Kaufman RJ. PKR protects colonic epithelium against colitis through the unfolded protein response and prosurvival signaling. Inflammatory Bowel Diseases. 18: 1735-42. PMID 22275310 DOI: 10.1002/ibd.22878  0.44
2012 Dickhout JG, Carlisle RE, Jerome DE, Mohammed-Ali Z, Jiang H, Yang G, Mani S, Garg SK, Banerjee R, Kaufman RJ, Maclean KN, Wang R, Austin RC. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. The Journal of Biological Chemistry. 287: 7603-14. PMID 22215680 DOI: 10.1074/jbc.M111.304576  0.44
2012 Majumder M, Huang C, Snider MD, Komar AA, Tanaka J, Kaufman RJ, Krokowski D, Hatzoglou M. A novel feedback loop regulates the response to endoplasmic reticulum stress via the cooperation of cytoplasmic splicing and mRNA translation. Molecular and Cellular Biology. 32: 992-1003. PMID 22215619 DOI: 10.1128/MCB.06665-11  0.44
2012 Zhang C, Wang G, Zheng Z, Maddipati KR, Zhang X, Dyson G, Williams P, Duncan SA, Kaufman RJ, Zhang K. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology (Baltimore, Md.). 55: 1070-82. PMID 22095841 DOI: 10.1002/hep.24783  0.44
2012 Selvaraj SR, Scheller AN, Miao HZ, Kaufman RJ, Pipe SW. Bioengineering of coagulation factor VIII for efficient expression through elimination of a dispensable disulfide loop Journal of Thrombosis and Haemostasis. 10: 107-115. PMID 22044596 DOI: 10.1111/j.1538-7836.2011.04545.x  0.44
2011 Kaufman RJ. Beta-cell failure, stress, and type 2 diabetes. The New England Journal of Medicine. 365: 1931-3. PMID 22087686 DOI: 10.1056/NEJMcibr1109442  0.44
2011 Fribley AM, Cruz PG, Miller JR, Callaghan MU, Cai P, Narula N, Neubig RR, Showalter HD, Larsen SD, Kirchhoff PD, Larsen MJ, Burr DA, Schultz PJ, Jacobs RR, Tamayo-Castillo G, ... ... Kaufman RJ, et al. Complementary cell-based high-throughput screens identify novel modulators of the unfolded protein response. Journal of Biomolecular Screening. 16: 825-35. PMID 21844328 DOI: 10.1177/1087057111414893  0.44
2011 Malhotra JD, Kaufman RJ. ER stress and its functional link to mitochondria: role in cell survival and death. Cold Spring Harbor Perspectives in Biology. 3: a004424. PMID 21813400 DOI: 10.1101/cshperspect.a004424  0.44
2011 Zhang B, Zheng C, Zhu M, Tao J, Vasievich MP, Baines A, Kim J, Schekman R, Kaufman RJ, Ginsburg D. Mice deficient in LMAN1 exhibit FV and FVIII deficiencies and liver accumulation of α1-antitrypsin. Blood. 118: 3384-91. PMID 21795745 DOI: 10.1182/blood-2011-05-352815  0.44
2011 Gao N, Shang J, Huynh D, Manthati VL, Arias C, Harding HP, Kaufman RJ, Mohr I, Ron D, Falck JR, Lehrman MA. Mannose-6-phosphate regulates destruction of lipid-linked oligosaccharides. Molecular Biology of the Cell. 22: 2994-3009. PMID 21737679 DOI: 10.1091/mbc.E11-04-0286  0.44
2011 Mielke N, Schwarzer R, Calkhoven CF, Kaufman RJ, Dörken B, Leutz A, Jundt F. Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice. Haematologica. 96: 1261-8. PMID 21565905 DOI: 10.3324/haematol.2011.042853  0.44
2011 Zhang K, Wang S, Malhotra J, Hassler JR, Back SH, Wang G, Chang L, Xu W, Miao H, Leonardi R, Chen YE, Jackowski S, Kaufman RJ. The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis. The Embo Journal. 30: 1357-75. PMID 21407177 DOI: 10.1038/emboj.2011.52  0.44
2011 Fribley AM, Miller JR, Reist TE, Callaghan MU, Kaufman RJ. Large-scale analysis of UPR-mediated apoptosis in human cells. Methods in Enzymology. 491: 57-71. PMID 21329794 DOI: 10.1016/B978-0-12-385928-0.00004-3  0.44
2011 Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metabolism. 13: 160-9. PMID 21284983 DOI: 10.1016/j.cmet.2011.01.003  0.44
2011 Malhi H, Kaufman RJ. Endoplasmic reticulum stress in liver disease. Journal of Hepatology. 54: 795-809. PMID 21145844 DOI: 10.1016/j.jhep.2010.11.005  0.44
2010 Kaufman RJ, Back SH, Song B, Han J, Hassler J. The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells. Diabetes, Obesity & Metabolism. 12: 99-107. PMID 21029306 DOI: 10.1111/j.1463-1326.2010.01281.x  0.44
2010 Greene TK, Wang C, Hirsch JD, Zhai L, Gewirtz J, Thornton MA, Miao HZ, Pipe SW, Kaufman RJ, Camire RM, Arruda VR, Kowalska MA, Poncz M. In vivo efficacy of platelet-delivered, high specific activity factor VIII variants. Blood. 116: 6114-22. PMID 20852129 DOI: 10.1182/blood-2010-06-293308  0.44
2010 Muaddi H, Majumder M, Peidis P, Papadakis AI, Holcik M, Scheuner D, Kaufman RJ, Hatzoglou M, Koromilas AE. Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency. Molecular Biology of the Cell. 21: 3220-31. PMID 20660158 DOI: 10.1091/mbc.E10-01-0023  0.44
2010 Poothong J, Sopha P, Kaufman RJ, Tirasophon W. Domain compatibility in Ire1 kinase is critical for the unfolded protein response. Febs Letters. 584: 3203-8. PMID 20541549 DOI: 10.1016/j.febslet.2010.06.003  0.44
2010 Kaufman RJ, Cao S. Inositol-requiring 1/X-box-binding protein 1 is a regulatory hub that links endoplasmic reticulum homeostasis with innate immunity and metabolism. Embo Molecular Medicine. 2: 189-92. PMID 20533428 DOI: 10.1002/emmm.201000076  0.44
2010 Pearse BR, Tamura T, Sunryd JC, Grabowski GA, Kaufman RJ, Hebert DN. The role of UDP-Glc:glycoprotein glucosyltransferase 1 in the maturation of an obligate substrate prosaposin. The Journal of Cell Biology. 189: 829-41. PMID 20498017 DOI: 10.1083/jcb.200912105  0.44
2010 Schulz O, Pichlmair A, Rehwinkel J, Rogers NC, Scheuner D, Kato H, Takeuchi O, Akira S, Kaufman RJ, Reis e Sousa C. Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host & Microbe. 7: 354-61. PMID 20478537 DOI: 10.1016/j.chom.2010.04.007  0.44
2010 Huang CC, Li Y, Lopez AB, Chiang CM, Kaufman RJ, Snider MD, Hatzoglou M. Temporal regulation of Cat-1 (cationic amino acid transporter-1) gene transcription during endoplasmic reticulum stress. The Biochemical Journal. 429: 215-24. PMID 20408811 DOI: 10.1042/BJ20100286  0.44
2010 Bevilacqua E, Wang X, Majumder M, Gaccioli F, Yuan CL, Wang C, Zhu X, Jordan LE, Scheuner D, Kaufman RJ, Koromilas AE, Snider MD, Holcik M, Hatzoglou M. eIF2alpha phosphorylation tips the balance to apoptosis during osmotic stress. The Journal of Biological Chemistry. 285: 17098-111. PMID 20338999 DOI: 10.1074/jbc.M110.109439  0.44
2010 Qiu Y, Mao T, Zhang Y, Shao M, You J, Ding Q, Chen Y, Wu D, Xie D, Lin X, Gao X, Kaufman RJ, Li W, Liu Y. A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells. Science Signaling. 3: ra7. PMID 20103773 DOI: 10.1126/scisignal.2000514  0.44
2010 Minor RA, Limmon GV, Miller-DeGraff L, Dixon D, Andrews DM, Kaufman RJ, Imani F. Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection. Journal of Interferon & Cytokine Research : the Official Journal of the International Society For Interferon and Cytokine Research. 30: 263-72. PMID 20038207 DOI: 10.1089/jir.2009.0051  0.44
2010 Malhotra JD, Kaufman RJ. ER and oxidative stress. implications in disease Handbook of Cell Signaling, 2/E. 3: 2301-2309. DOI: 10.1016/B978-0-12-374145-5.00276-X  0.44
2010 Callaghan MU, Kaufman RJ. Cellular Processing of Factor VIII and Factor IX Textbook of Hemophilia: Second Edition. 13-23. DOI: 10.1002/9781444318555.ch2  0.44
2010 Malhotra JD, Kaufman RJ. Endoplasmic Reticulum Stress and Oxidative Stress: Mechanisms and Link to Disease Protein Misfolding Diseases: Current and Emerging Principles and Therapies. 21-46. DOI: 10.1002/9780470572702.ch2  0.44
2010 Kaufman RJ. Protein folding, oxidative stress, and the unfolded protein response International Journal of Clinical Pharmacology and Therapeutics. 48.  0.44
2009 Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM, Koromilas AE. Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway. Science Signaling. 2: ra85. PMID 20029030 DOI: 10.1126/scisignal.2000389  0.44
2009 Vecchi C, Montosi G, Zhang K, Lamberti I, Duncan SA, Kaufman RJ, Pietrangelo A. ER stress controls iron metabolism through induction of hepcidin. Science (New York, N.Y.). 325: 877-80. PMID 19679815 DOI: 10.1126/science.1176639  0.44
2009 Fribley A, Zhang K, Kaufman RJ. Regulation of apoptosis by the unfolded protein response. Methods in Molecular Biology (Clifton, N.J.). 559: 191-204. PMID 19609758 DOI: 10.1007/978-1-60327-017-5_14  0.44
2009 Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S, Kaufman RJ. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metabolism. 10: 13-26. PMID 19583950 DOI: 10.1016/j.cmet.2009.06.002  0.44
2009 DuRose JB, Scheuner D, Kaufman RJ, Rothblum LI, Niwa M. Phosphorylation of eukaryotic translation initiation factor 2alpha coordinates rRNA transcription and translation inhibition during endoplasmic reticulum stress. Molecular and Cellular Biology. 29: 4295-307. PMID 19470760 DOI: 10.1128/MCB.00260-09  0.44
2009 Davies MJ, Miranda E, Roussel BD, Kaufman RJ, Marciniak SJ, Lomas DA. Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response. The Journal of Biological Chemistry. 284: 18202-9. PMID 19423713 DOI: 10.1074/jbc.M109.010744  0.44
2009 Bommiasamy H, Back SH, Fagone P, Lee K, Meshinchi S, Vink E, Sriburi R, Frank M, Jackowski S, Kaufman RJ, Brewer JW. ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. Journal of Cell Science. 122: 1626-36. PMID 19420237 DOI: 10.1242/jcs.045625  0.44
2009 Mokas S, Mills JR, Garreau C, Fournier MJ, Robert F, Arya P, Kaufman RJ, Pelletier J, Mazroui R. Uncoupling stress granule assembly and translation initiation inhibition. Molecular Biology of the Cell. 20: 2673-83. PMID 19369421 DOI: 10.1091/mbc.E08-10-1061  0.44
2009 Harding HP, Zhang Y, Scheuner D, Chen JJ, Kaufman RJ, Ron D. Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development. Proceedings of the National Academy of Sciences of the United States of America. 106: 1832-7. PMID 19181853 DOI: 10.1073/pnas.0809632106  0.44
2009 Wang J, Farr GW, Zeiss CJ, Rodriguez-Gil DJ, Wilson JH, Furtak K, Rutkowski DT, Kaufman RJ, Ruse CI, Yates JR, Perrin S, Feany MB, Horwich AL. Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS. Proceedings of the National Academy of Sciences of the United States of America. 106: 1392-7. PMID 19171884 DOI: 10.1073/pnas.0813045106  0.44
2009 Back SH, Hassler JR, Kaufman RJ. The unfolded protein response in mammalian cells Protein Misfolding Disorders: a Trip Into the Er. 19-46. DOI: 10.2174/978160805013010901010019  0.44
2008 Rutkowski DT, Wu J, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, ... ... Kaufman RJ, et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. Developmental Cell. 15: 829-40. PMID 19081072 DOI: 10.1016/j.devcel.2008.10.015  0.44
2008 Malhotra JD, Miao H, Zhang K, Wolfson A, Pennathur S, Pipe SW, Kaufman RJ. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proceedings of the National Academy of Sciences of the United States of America. 105: 18525-30. PMID 19011102 DOI: 10.1073/pnas.0809677105  0.44
2008 Kim J, Choi TG, Ding Y, Kim Y, Ha KS, Lee KH, Kang I, Ha J, Kaufman RJ, Lee J, Choe W, Kim SS. Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress. Journal of Cell Science. 121: 3636-48. PMID 18946027 DOI: 10.1242/jcs.028654  0.44
2008 Brosius FC, Kaufman RJ. Is the ER stressed out in diabetic kidney disease? Journal of the American Society of Nephrology : Jasn. 19: 2040-2. PMID 18842986 DOI: 10.1681/ASN.2008090959  0.44
2008 Song B, Scheuner D, Ron D, Pennathur S, Kaufman RJ. Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. The Journal of Clinical Investigation. 118: 3378-89. PMID 18776938 DOI: 10.1172/JCI34587  0.44
2008 Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. Hepatocyte nuclear factor 4alpha is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of cyclic adenosine monophosphate responsive element binding protein H. Hepatology (Baltimore, Md.). 48: 1242-50. PMID 18704925 DOI: 10.1002/hep.22439  0.44
2008 Sakaki K, Kaufman RJ. Regulation of ER stress-induced macroautophagy by protein kinase C. Autophagy. 4: 841-3. PMID 18670192  0.44
2008 Yamamoto K, Suzuki N, Wada T, Okada T, Yoshida H, Kaufman RJ, Mori K. Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds. Journal of Biochemistry. 144: 477-86. PMID 18664523 DOI: 10.1093/jb/mvn091  0.44
2008 Zhang K, Kaufman RJ. Chapter Twenty Identification and Characterization of Endoplasmic Reticulum Stress-Induced Apoptosis In Vivo Methods in Enzymology. 442: 395-419. PMID 18662581 DOI: 10.1016/S0076-6879(08)01420-1  0.44
2008 Farhan H, Weiss M, Tani K, Kaufman RJ, Hauri HP. Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load. The Embo Journal. 27: 2043-54. PMID 18650939 DOI: 10.1038/emboj.2008.136  0.44
2008 Zhang K, Kaufman RJ. From endoplasmic-reticulum stress to the inflammatory response Nature. 454: 455-462. PMID 18650916 DOI: 10.1038/nature07203  0.44
2008 Mak BC, Wang Q, Laschinger C, Lee W, Ron D, Harding HP, Kaufman RJ, Scheuner D, Austin RC, McCulloch CA. Novel function of PERK as a mediator of force-induced apoptosis. The Journal of Biological Chemistry. 283: 23462-72. PMID 18550523 DOI: 10.1074/jbc.M803194200  0.44
2008 Scheuner D, Kaufman RJ. The unfolded protein response: A pathway that links insulin demand with β-cell failure and diabetes Endocrine Reviews. 29: 317-333. PMID 18436705 DOI: 10.1210/er.2007-0039  0.44
2008 Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan MU, Avci Z, Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham EG, Seligsohn U, Peyvandi F, et al. Genotype-phenotype correlation in combined deficiency of factor V and factor VIII. Blood. 111: 5592-600. PMID 18391077 DOI: 10.1182/blood-2007-10-113951  0.44
2008 Sakaki K, Wu J, Kaufman RJ. Protein kinase Ctheta is required for autophagy in response to stress in the endoplasmic reticulum. The Journal of Biological Chemistry. 283: 15370-80. PMID 18356160 DOI: 10.1074/jbc.M710209200  0.44
2008 Thiaville MM, Pan YX, Gjymishka A, Zhong C, Kaufman RJ, Kilberg MS. MEK signaling is required for phosphorylation of eIF2alpha following amino acid limitation of HepG2 human hepatoma cells. The Journal of Biological Chemistry. 283: 10848-57. PMID 18287093 DOI: 10.1074/jbc.M708320200  0.44
2008 Zeenko VV, Wang C, Majumder M, Komar AA, Snider MD, Merrick WC, Kaufman RJ, Hatzoglou M. An efficient in vitro translation system from mammalian cells lacking the translational inhibition caused by eIF2 phosphorylation Rna. 14: 593-602. PMID 18230759 DOI: 10.1261/rna.825008  0.44
2007 Malhotra JD, Kaufman RJ. The endoplasmic reticulum and the unfolded protein response Seminars in Cell and Developmental Biology. 18: 716-731. PMID 18023214 DOI: 10.1016/j.semcdb.2007.09.003  0.44
2007 Malhotra JD, Kaufman RJ. Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword? Antioxidants and Redox Signaling. 9: 2277-2293. PMID 17979528 DOI: 10.1089/ars.2007.1782  0.44
2007 Rutkowski DT, Kaufman RJ. That which does not kill me makes me stronger: adapting to chronic ER stress. Trends in Biochemical Sciences. 32: 469-76. PMID 17920280 DOI: 10.1016/j.tibs.2007.09.003  0.44
2007 Cerullo V, Seiler MP, Mane V, Cela R, Clarke C, Kaufman RJ, Pipe SW, Lee B. Correction of murine hemophilia A and immunological differences of factor VIII variants delivered by helper-dependent adenoviral vectors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 2080-7. PMID 17848960 DOI: 10.1038/sj.mt.6300308  0.44
2007 Wu J, Rutkowski DT, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD, Kaufman RJ. ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Developmental Cell. 13: 351-64. PMID 17765679 DOI: 10.1016/j.devcel.2007.07.005  0.44
2007 Soldà T, Galli C, Kaufman RJ, Molinari M. Substrate-Specific Requirements for UGT1-Dependent Release from Calnexin Molecular Cell. 27: 238-249. PMID 17643373 DOI: 10.1016/j.molcel.2007.05.032  0.44
2007 Drogat B, Auguste P, Nguyen DT, Bouchecareilh M, Pineau R, Nalbantoglu J, Kaufman RJ, Chevet E, Bikfalvi A, Moenner M. IRE1 signaling is essential for ischemia-induced vascular endothelial growth factor-A expression and contributes to angiogenesis and tumor growth in vivo. Cancer Research. 67: 6700-7. PMID 17638880 DOI: 10.1158/0008-5472.CAN-06-3235  0.44
2007 Rutkowski DT, Kang SW, Goodman AG, Garrison JL, Taunton J, Katze MG, Kaufman RJ, Hegde RS. The role of p58IPK in protecting the stressed endoplasmic reticulum. Molecular Biology of the Cell. 18: 3681-91. PMID 17567950 DOI: 10.1091/mbc.E07-03-0272  0.44
2007 Renna M, Caporaso MG, Bonatti S, Kaufman RJ, Remondelli P. Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress Journal of Biological Chemistry. 282: 22499-22512. PMID 17535801 DOI: 10.1074/jbc.M703778200  0.44
2007 Mazroui R, Di Marco S, Kaufman RJ, Gallouzi IE. Inhibition of the ubiquitin-proteasome system induces stress granule formation. Molecular Biology of the Cell. 18: 2603-18. PMID 17475769 DOI: 10.1091/mbc.E06-12-1079  0.44
2007 Nagasawa K, Higashi T, Hosokawa N, Kaufman RJ, Nagata K. Simultaneous induction of the four subunits of the TRAP complex by ER stress accelerates ER degradation Embo Reports. 8: 483-489. PMID 17380188 DOI: 10.1038/sj.embor.7400933  0.44
2007 Zhu A, Sun H, Raymond RM, Furie BC, Furie B, Bronstein M, Kaufman RJ, Westrick R, Ginsburg D. Fatal hemorrhage in mice lacking gamma-glutamyl carboxylase. Blood. 109: 5270-5. PMID 17327402 DOI: 10.1182/blood-2006-12-064188  0.44
2007 Shang J, Gao N, Kaufman RJ, Ron D, Harding HP, Lehrman MA. Translation attenuation by PERK balances ER glycoprotein synthesis with lipid-linked oligosaccharide flux. The Journal of Cell Biology. 176: 605-16. PMID 17325203 DOI: 10.1083/jcb.200607007  0.44
2007 Vander Mierde D, Scheuner D, Quintens R, Patel R, Song B, Tsukamoto K, Beullens M, Kaufman RJ, Bollen M, Schuit FC. Glucose activates a protein phosphatase-1-mediated signaling pathway to enhance overall translation in pancreatic β-cells Endocrinology. 148: 609-617. PMID 17082262 DOI: 10.1210/en.2006-1012  0.44
2007 Kouroku Y, Fujita E, Tanida I, Ueno T, Isoai A, Kumagai H, Ogawa S, Kaufman RJ, Kominami E, Momoi T. ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation Cell Death and Differentiation. 14: 230-239. PMID 16794605 DOI: 10.1038/sj.cdd.4401984  0.44
2006 Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D, Kaufman RJ. Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. Plos Biology. 4: e374. PMID 17090218 DOI: 10.1371/journal.pbio.0040374  0.44
2006 Nyfeler B, Zhang B, Ginsburg D, Kaufman RJ, Hauri HP. Cargo selectivity of the ERGIC-53/MCFD2 transport receptor complex. Traffic (Copenhagen, Denmark). 7: 1473-81. PMID 17010120 DOI: 10.1111/j.1600-0854.2006.00483.x  0.44
2006 Zhou J, Liu CY, Back SH, Clark RL, Peisach D, Xu Z, Kaufman RJ. The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proceedings of the National Academy of Sciences of the United States of America. 103: 14343-8. PMID 16973740 DOI: 10.1073/pnas.0606480103  0.44
2006 Denoyelle C, Abou-Rjaily G, Bezrookove V, Verhaegen M, Johnson TM, Fullen DR, Pointer JN, Gruber SB, Su LD, Nikiforov MA, Kaufman RJ, Bastian BC, Soengas MS. Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway. Nature Cell Biology. 8: 1053-63. PMID 16964246 DOI: 10.1038/ncb1471  0.44
2006 Robert F, Kapp LD, Khan SN, Acker MG, Kolitz S, Kazemi S, Kaufman RJ, Merrick WC, Koromilas AE, Lorsch JR, Pelletier J. Initiation of protein synthesis by hepatitis C virus is refractory to reduced eIF2.GTP.Met-tRNA(i)(Met) ternary complex availability. Molecular Biology of the Cell. 17: 4632-44. PMID 16928960 DOI: 10.1091/mbc.E06-06-0478  0.44
2006 Fribley AM, Evenchik B, Zeng Q, Park BK, Guan JY, Zhang H, Hale TJ, Soengas MS, Kaufman RJ, Wang CY. Proteasome inhibitor PS-341 induces apoptosis in cisplatin-resistant squamous cell carcinoma cells by induction of Noxa. The Journal of Biological Chemistry. 281: 31440-7. PMID 16928686 DOI: 10.1074/jbc.M604356200  0.44
2006 Mazroui R, Sukarieh R, Bordeleau ME, Kaufman RJ, Northcote P, Tanaka J, Gallouzi I, Pelletier J. Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2α phosphorylation Molecular Biology of the Cell. 17: 4212-4219. PMID 16870703 DOI: 10.1091/mbc.E06-04-0318  0.44
2006 Scheuner D, Patel R, Wang F, Lee K, Kumar K, Wu J, Nilsson A, Karin M, Kaufman RJ. Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis. The Journal of Biological Chemistry. 281: 21458-68. PMID 16717090 DOI: 10.1074/jbc.M603784200  0.44
2006 Back SH, Lee K, Vink E, Kaufman RJ. Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. The Journal of Biological Chemistry. 281: 18691-706. PMID 16644724 DOI: 10.1074/jbc.M602030200  0.44
2006 Zhang K, Kaufman RJ. Protein folding in the endoplasmic reticulum and the unfolded protein response Handbook of Experimental Pharmacology. 172: 69-91. PMID 16610355 DOI: 10.1007/3-540-29717-0-3  0.44
2006 Hu P, Han Z, Couvillon AD, Kaufman RJ, Exton JH. Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression Molecular and Cellular Biology. 26: 3071-3084. PMID 16581782 DOI: 10.1128/MCB.26.8.3071-3084.2006  0.44
2006 Schröder M, Kaufman RJ. Divergent roles of IRE1alpha and PERK in the unfolded protein response. Current Molecular Medicine. 6: 5-36. PMID 16472110 DOI: 10.2174/156652406775574569  0.44
2006 Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ. Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 124: 587-99. PMID 16469704 DOI: 10.1016/j.cell.2005.11.040  0.44
2006 Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. The Embo Journal. 25: 1114-25. PMID 16467844 DOI: 10.1038/sj.emboj.7600998  0.44
2006 Oda Y, Okada T, Yoshida H, Kaufman RJ, Nagata K, Mori K. Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation. The Journal of Cell Biology. 172: 383-93. PMID 16449189 DOI: 10.1083/jcb.200507057  0.44
2006 Smith JA, Schmechel SC, Raghavan A, Abelson M, Reilly C, Katze MG, Kaufman RJ, Bohjanen PR, Schiff LA. Reovirus induces and benefits from an integrated cellular stress response. Journal of Virology. 80: 2019-33. PMID 16439558 DOI: 10.1128/JVI.80.4.2019-2033.2006  0.44
2006 Zhang K, Kaufman RJ. The unfolded protein response: A stress signaling pathway critical for health and disease Neurology. 66. PMID 16432136  0.44
2006 Wu J, Kaufman RJ. From acute ER stress to physiological roles of the unfolded protein response Cell Death and Differentiation. 13: 374-384. PMID 16397578 DOI: 10.1038/sj.cdd.4401840  0.44
2006 Zhang B, McGee B, Yamaoka JS, Guglielmone H, Downes KA, Minoldo S, Jarchum G, Peyvandi F, De Bosch NB, Ruiz-Saez A, Chatelain B, Olpinski M, Bockenstedt P, Sperl W, Kaufman RJ, et al. Combined deficiency of factor V and factor VIII is due to mutations in either LMAN1 or MCFD2 Blood. 107: 1903-1907. PMID 16304051 DOI: 10.1182/blood-2005-09-3620  0.44
2005 Harding HP, Zhang Y, Khersonsky S, Marciniak S, Scheuner D, Kaufman RJ, Javitt N, Chang YT, Ron D. Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell Metabolism. 2: 361-71. PMID 16330322 DOI: 10.1016/j.cmet.2005.11.005  0.44
2005 Molinari M, Galli C, Vanoni O, Arnold SM, Kaufman RJ. Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence Molecular Cell. 20: 503-512. PMID 16307915 DOI: 10.1016/j.molcel.2005.09.027  0.44
2005 Shen X, Ellis RE, Sakaki K, Kaufman RJ. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Plos Genetics. 1: e37. PMID 16184190 DOI: 10.1371/journal.pgen.0010037  0.48
2005 Bi M, Naczki C, Koritzinsky M, Fels D, Blais J, Hu N, Harding H, Novoa I, Varia M, Raleigh J, Scheuner D, Kaufman RJ, Bell J, Ron D, Wouters BG, et al. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. The Embo Journal. 24: 3470-81. PMID 16148948 DOI: 10.1038/sj.emboj.7600777  0.44
2005 Scheuner D, Mierde DV, Song B, Flamez D, Creemers JWM, Tsukamoto K, Ribick M, Schuit FC, Kaufman RJ. Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis Nature Medicine. 11: 757-764. PMID 15980866 DOI: 10.1038/nm1259  0.44
2005 Kedersha N, Stoecklin G, Ayodele M, Yacono P, Lykke-Andersen J, Fritzler MJ, Scheuner D, Kaufman RJ, Golan DE, Anderson P. Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. The Journal of Cell Biology. 169: 871-84. PMID 15967811 DOI: 10.1083/jcb.200502088  0.44
2005 Schröder M, Kaufman RJ. The mammalian unfolded protein response. Annual Review of Biochemistry. 74: 739-89. PMID 15952902 DOI: 10.1146/annurev.biochem.73.011303.074134  0.44
2005 McInerney GM, Kedersha NL, Kaufman RJ, Anderson P, Liljeström P. Importance of eIF2α phosphorylation and stress granule assembly in alphavirus translation regulation Molecular Biology of the Cell. 16: 3753-3763. PMID 15930128 DOI: 10.1091/mbc.E05-02-0124  0.44
2005 Zhang B, Kaufman RJ, Ginsburg D. LMAN1 and MCFD2 form a cargo receptor complex and interact with coagulation factor VIII in the early secretory pathway Journal of Biological Chemistry. 280: 25881-25886. PMID 15886209 DOI: 10.1074/jbc.M502160200  0.44
2005 Back SH, Schröder M, Lee K, Zhang K, Kaufman RJ. ER stress signaling by regulated splicing: IRE1/HAC1/XBP1. Methods (San Diego, Calif.). 35: 395-416. PMID 15804613 DOI: 10.1016/j.ymeth.2005.03.001  0.44
2005 Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J. A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (New York, N.Y.). 307: 935-9. PMID 15705855 DOI: 10.1126/science.1101902  0.44
2005 Fernandez J, Yaman I, Huang C, Liu H, Lopez AB, Komar AA, Caprara MG, Merrick WC, Snider MD, Kaufman RJ, Lamers WH, Hatzoglou M. Ribosome stalling regulates ires-mediated translation in eukaryotes, a parallel to prokaryotic attenuation Molecular Cell. 17: 405-416. PMID 15694341 DOI: 10.1016/j.molcel.2004.12.024  0.44
2005 Zhang K, Wong HN, Song B, Miller CN, Scheuner D, Kaufman RJ. The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. The Journal of Clinical Investigation. 115: 268-81. PMID 15690081 DOI: 10.1172/JCI21848  0.44
2005 McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ. Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure Journal of Biological Chemistry. 280: 16925-16933. PMID 15684421 DOI: 10.1074/jbc.M412882200  0.44
2005 Schröder M, Kaufman RJ. ER stress and the unfolded protein response. Mutation Research. 569: 29-63. PMID 15603751 DOI: 10.1016/j.mrfmmm.2004.06.056  0.44
2004 Yamamoto K, Yoshida H, Kokame K, Kaufman RJ, Mori K. Differential contributions of ATF6 and XBP1 to the activation of endoplasmic reticulum stress-responsive cis-acting elements ERSE, UPRE and ERSE-II. Journal of Biochemistry. 136: 343-50. PMID 15598891 DOI: 10.1093/jb/mvh122  0.44
2004 Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology. 24: 10161-8. PMID 15542827 DOI: 10.1128/MCB.24.23.10161-10168.2004  0.44
2004 Shen X, Zhang K, Kaufman RJ. The unfolded protein response--a stress signaling pathway of the endoplasmic reticulum. Journal of Chemical Neuroanatomy. 28: 79-92. PMID 15363493 DOI: 10.1016/j.jchemneu.2004.02.006  0.44
2004 Wu S, Kaufman RJ. trans-Autophosphorylation by the isolated kinase domain is not sufficient for dimerization or activation of the dsRNA-activated protein kinase PKR. Biochemistry. 43: 11027-34. PMID 15323561 DOI: 10.1021/bi0360105  0.44
2004 Ye P, Thompson AR, Sarkar R, Shen Z, Lillicrap DP, Kaufman RJ, Ochs HD, Rawlings DJ, Miao CH. Naked DNA transfer of Factor VIII induced transgene-specific, species-independent immune response in hemophilia A mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 10: 117-26. PMID 15233948 DOI: 10.1016/j.ymthe.2004.04.009  0.44
2004 Nguyên DT, Kebache S, Fazel A, Wong HN, Jenna S, Emadali A, Lee EH, Bergeron JJ, Kaufman RJ, Larose L, Chevet E. Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress. Molecular Biology of the Cell. 15: 4248-60. PMID 15201339 DOI: 10.1091/mbc.E03-11-0851  0.44
2004 Wu S, Tan M, Hu Y, Wang JL, Scheuner D, Kaufman RJ. Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis. The Journal of Biological Chemistry. 279: 34898-902. PMID 15184376 DOI: 10.1074/jbc.M405616200  0.44
2004 Schröder M, Clark R, Liu CY, Kaufman RJ. The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase. The Embo Journal. 23: 2281-92. PMID 15141165 DOI: 10.1038/sj.emboj.7600233  0.44
2004 Zhang K, Kaufman RJ. Signaling the unfolded protein response from the endoplasmic reticulum Journal of Biological Chemistry. 279: 25935-25938. PMID 15070890 DOI: 10.1074/jbc.R400008200  0.44
2004 Hsu LC, Park JM, Zhang K, Luo JL, Maeda S, Kaufman RJ, Eckmann L, Guiney DG, Karin M. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature. 428: 341-5. PMID 15029200 DOI: 10.1038/nature02405  0.44
2004 Kaufman RJ. Regulation of mRNA translation by protein folding in the endoplasmic reticulum Trends in Biochemical Sciences. 29: 152-158. PMID 15003273 DOI: 10.1016/j.tibs.2004.01.004  0.44
2004 Tardif KD, Mori K, Kaufman RJ, Siddiqui A. Hepatitis C virus suppresses the IRE1-XBP1 pathway of the unfolded protein response. The Journal of Biological Chemistry. 279: 17158-64. PMID 14960590 DOI: 10.1074/jbc.M312144200  0.44
2004 Rutkowski DT, Kaufman RJ. A trip to the ER: coping with stress. Trends in Cell Biology. 14: 20-8. PMID 14729177 DOI: 10.1016/j.tcb.2003.11.001  0.44
2004 Miao HZ, Sirachainan N, Palmer L, Kucab P, Cunningham MA, Kaufman RJ, Pipe SW. Bioengineering of coagulation factor VIII for improved secretion Blood. 103: 3412-3419. PMID 14726380 DOI: 10.1182/blood-2003-10-3591  0.44
2004 Lu PD, Jousse C, Marciniak SJ, Zhang Y, Novoa I, Scheuner D, Kaufman RJ, Ron D, Harding HP. Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2. The Embo Journal. 23: 169-79. PMID 14713949 DOI: 10.1038/sj.emboj.7600030  0.44
2004 Wiederkehr C, Basavaraj R, Sarrauste de Menthière C, Hermida L, Koch R, Schlecht U, Amon A, Brachat S, Breitenbach M, Briza P, Caburet S, Cherry M, Davis R, Deutschbauer A, Dickinson HG, ... ... Kaufman RJ, et al. GermOnline, a cross-species community knowledgebase on germ cell differentiation. Nucleic Acids Research. 32: D560-7. PMID 14681481 DOI: 10.1093/nar/gkh055  0.44
2003 Scheuner D, Gromeier M, Davies MV, Dorner AJ, Song B, Patel RV, Wimmer EJ, McLendon RE, Kaufman RJ. The double-stranded RNA-activated protein kinase mediates viral-induced encephalitis. Virology. 317: 263-74. PMID 14698665 DOI: 10.1016/j.virol.2003.08.010  0.44
2003 Aparna G, Bhuyan AK, Sahdev S, Hasnain SE, Kaufman RJ, Ramaiah KV. Stress-induced apoptosis in Spodoptera frugiperda (Sf9) cells: baculovirus p35 mitigates eIF2 alpha phosphorylation. Biochemistry. 42: 15352-60. PMID 14690445 DOI: 10.1021/bi0349423  0.44
2003 Cunningham MA, Pipe SW, Zhang B, Hauri HP, Ginsburg D, Kaufman RJ. LMAN1 is a molecular chaperone for the secretion of coagulation factor VIII. Journal of Thrombosis and Haemostasis : Jth. 1: 2360-7. PMID 14629470 DOI: 10.1046/j.1538-7836.2003.00415.x  0.44
2003 Cullinan SB, Zhang D, Hannink M, Arvisais E, Kaufman RJ, Diehl JA. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Molecular and Cellular Biology. 23: 7198-209. PMID 14517290 DOI: 10.1128/MCB.23.20.7198-7209.2003  0.44
2003 Zhang K, Kaufman RJ. Unfolding the toxicity of cholesterol Nature Cell Biology. 5: 769-770. PMID 12951604 DOI: 10.1038/ncb0903-769  0.44
2003 Arnold SM, Kaufman RJ. The Noncatalytic Portion of Human UDP-glucose:Glycoprotein Glucosyltransferase I Confers UDP-glucose Binding and Transferase Function to the Catalytic Domain Journal of Biological Chemistry. 278: 43320-43328. PMID 12913004 DOI: 10.1074/jbc.M305800200  0.44
2003 Kaufman RJ. Good things come in small packages for hemophilia Journal of Thrombosis and Haemostasis. 1: 2472-2473. DOI: 10.1111/j.1538-7836.2003.00540.x  0.44
2003 Stacey Arnold M, Kaufman RJ. Protein synthesis, folding, modification, and secretion in mammalian cells New Comprehensive Biochemistry. 38: 411-432. DOI: 10.1016/S0167-7306(03)38025-1  0.44
2002 Kaufman RJ, Scheuner D, Schröder M, Shen X, Lee K, Liu CY, Arnold SM. The unfolded protein response in nutrient sensing and differentiation. Nature Reviews. Molecular Cell Biology. 3: 411-21. PMID 12042763 DOI: 10.1038/nrm829  0.48
2002 Lee K, Tirasophon W, Shen X, Michalak M, Prywes R, Okada T, Yoshida H, Mori K, Kaufman RJ. IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. Genes & Development. 16: 452-66. PMID 11850408 DOI: 10.1101/gad.964702  0.48
2001 Shen X, Ellis RE, Lee K, Liu CY, Yang K, Solomon A, Yoshida H, Morimoto R, Kurnit DM, Mori K, Kaufman RJ. Complementary signaling pathways regulate the unfolded protein response and are required for C. elegans development. Cell. 107: 893-903. PMID 11779465  0.48
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