Larry H. Matherly - Publications

Affiliations: 
Wayne State University, Detroit, MI, United States 
Area:
Pharmacology, Biochemistry, Molecular Biology
Website:
https://cancerbiologyprogram.med.wayne.edu/faculty/matherly

171 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dekhne AS, Hou Z, Gangjee A, Matherly LH. Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer. Molecular Cancer Therapeutics. PMID 32879053 DOI: 10.1158/1535-7163.MCT-20-0423  0.32
2020 Golani LK, Islam F, O'Connor C, Dekhne AS, Hou Z, Matherly LH, Gangjee A. Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier. Bioorganic & Medicinal Chemistry. 28: 115544. PMID 32503687 DOI: 10.1016/j.bmc.2020.115544  0.32
2019 Dekhne AS, Ning C, Nayeen MJ, Shah K, Kalpage H, Fruhauf J, Wallace-Povirk A, O'Connor C, Hou Z, Kim S, Huttemann M, Gangjee A, Matherly LH. Cellular pharmacodynamics of a novel pyrrolo[3,2-d]pyrimidine inhibitor targeting mitochondrial and cytosolic one-carbon metabolism. Molecular Pharmacology. PMID 31707355 DOI: 10.1124/mol.119.117937  0.32
2019 Xiang W, Dekhne A, Doshi A, O'Connor C, Hou Z, Matherly LH, Gangjee A. Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis. Bioorganic & Medicinal Chemistry. 115125. PMID 31679978 DOI: 10.1016/j.bmc.2019.115125  0.32
2019 Dekhne AS, Shah K, Ducker GS, Katinas JM, Wong-Roushar J, Nayeen MJ, Doshi A, Ning C, Bao X, Frühauf J, Liu J, Wallace-Povirk A, O'Connor C, Dzinic SH, White K, ... ... Matherly LH, et al. Novel pyrrolo[3,2-d]pyrimidine compounds target mitochondrial and cytosolic one-carbon metabolism with broad-spectrum antitumor efficacy. Molecular Cancer Therapeutics. PMID 31289137 DOI: 10.1158/1535-7163.MCT-19-0037  0.32
2019 Hou Z, O'Connor C, Frühauf J, Orr S, Kim S, Gangjee A, Matherly LH. Regulation of differential proton-coupled folate transporter gene expression in human tumors: Transactivation by KLF15 with NRF-1 and role of Sp1. The Biochemical Journal. PMID 30914440 DOI: 10.1042/BCJ20180394  0.32
2018 Ravindra M, Wilson MR, Tong N, O'Connor C, Karim M, Polin L, Wallace-Povirk A, White K, Kushner J, Hou Z, Matherly LH, Gangjee A. Fluorine-Substituted Pyrrolo[2,3- d]Pyrimidine Analogues with Tumor Targeting via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis. Journal of Medicinal Chemistry. PMID 29701475 DOI: 10.1021/acs.jmedchem.8b00408  0.32
2018 Shah K, Raghavan S, Hou Z, Matherly LH, Gangjee A. Development and validation of chemical features-based proton-coupled folate transporter/activity and reduced folate carrier/activity models (pharmacophores). Journal of Molecular Graphics & Modelling. 81: 125-133. PMID 29550744 DOI: 10.1016/j.jmgm.2018.02.007  0.32
2018 Ravindra M, Wallace-Povirk A, Karim MA, Wilson MR, O'Connor CE, White K, Kushner J, Polin LA, George C, Hou Z, Matherly LH, Gangjee A. Tumor Targeting with Novel Pyridyl 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolates Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Journal of Medicinal Chemistry. PMID 29425443 DOI: 10.1021/acs.jmedchem.7b01708  0.32
2017 Matherly LH, Hou Z, Gangjee A. The promise and challenges of exploiting the proton-coupled folate transporter for selective therapeutic targeting of cancer. Cancer Chemotherapy and Pharmacology. PMID 29127457 DOI: 10.1007/s00280-017-3473-8  0.32
2017 Giovannetti E, Zucali PA, Assaraf YG, Funel N, Gemelli M, Stark M, Thunnissen E, Hou Z, Muller IB, Struijs EA, Perrino M, Jansen G, Matherly LH, Peters GJ. Role of proton-coupled folate transporter in pemetrexed-resistance of mesothelioma: clinical evidence and new pharmacological tools. Annals of Oncology : Official Journal of the European Society For Medical Oncology. PMID 28945836 DOI: 10.1093/annonc/mdx499  0.32
2017 Deis SM, Doshi A, Hou Z, Matherly LH, Gangjee A, Dann CE. Correction to Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase. Biochemistry. PMID 28186409 DOI: 10.1021/acs.biochem.7b00092  0.32
2017 Hou Z, Gattoc L, O'Connor C, Yang S, Wallace-Povirk A, George C, Orr S, Polin L, White K, Kushner J, Morris RT, Gangjee A, Matherly LH. Dual targeting of epithelial ovarian cancer via folate receptor α and the proton-coupled folate transporter with 6-substituted pyrrolo[2,3-d]pyrimidine antifolates. Molecular Cancer Therapeutics. PMID 28138029 DOI: 10.1158/1535-7163.MCT-16-0444  0.32
2016 Edwards H, Rubenstein M, Dombkowski AA, Caldwell JT, Chu R, Xavier AC, Thummel R, Neely M, Matherly LH, Ge Y, Taub JW. Gene Signature of High White Blood Cell Count in B-Precursor Acute Lymphoblastic Leukemia. Plos One. 11: e0161539. PMID 27536776 DOI: 10.1371/journal.pone.0161539  1
2016 Wilson MR, Hou Z, Wilson LJ, Ye J, Matherly LH. Functional and mechanistic roles of the human proton-coupled folate transporter transmembrane domain 6-7 linker. The Biochemical Journal. PMID 27514717 DOI: 10.1042/BCJ20160399  0.32
2016 Golani LK, Wallace-Povirk A, Deis SM, Wong JE, Ke J, Gu X, Raghavan S, Wilson MR, Li X, Polin LA, de Waal PW, White K, Kushner J, O'Connor CE, Hou Z, ... ... Matherly LH, et al. Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor α and the Proton-coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis. Journal of Medicinal Chemistry. PMID 27458733 DOI: 10.1021/acs.jmedchem.6b00594  1
2016 Deis SM, Doshi A, Hou Z, Matherly LH, Gangjee A, Dann Iii CE. Structural and enzymatic analysis of tumor-targeted antifolates that inhibit glycinamide ribonucleotide formyltransferase. Biochemistry. PMID 27439469 DOI: 10.1021/acs.biochem.6b00412  1
2016 Golani LK, George C, Zhao S, Raghavan S, Orr S, Wallace A, Wilson MR, Hou Z, Matherly LH, Gangjee A. Correction to Structure-Activity Profiles of Novel 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Antifolates with Modified Amino Acids for Cellular Uptake by Folate Receptors α and β and the Proton-Coupled Folate Transporter. Journal of Medicinal Chemistry. PMID 27082426 DOI: 10.1021/acs.jmedchem.6b00502  0.32
2016 Wilson MR, Hou Z, Yang S, Polin L, Kushner J, White K, Huang J, Ratnam M, Gangjee A, Matherly LH. Targeting Non-Squamous Non-Small Cell Lung Cancer Via the Proton-Coupled Folate Transporter with 6-Substituted Pyrrolo[2,3-d]Pyrimidine Thienoyl Antifolates. Molecular Pharmacology. PMID 26837243 DOI: 10.1124/mol.115.102798  1
2015 Wang L, Wallace A, Raghavan S, Deis SM, Wilson MR, Yang S, Polin L, White K, Kushner J, Orr S, George C, O'Connor C, Hou Z, Mitchell-Ryan S, Dann CE, ... Matherly LH, et al. 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor α and the Proton-Coupled Folate Transporter in Human Tumors. Journal of Medicinal Chemistry. PMID 26317331 DOI: 10.1021/acs.jmedchem.5b00801  1
2015 Wilson MR, Kugel S, Huang J, Wilson LJ, Wloszczynski PA, Ye J, Matherly LH, Hou Z. Structural determinants of human proton-coupled folate transporter oligomerization: role of GXXXG motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6. The Biochemical Journal. PMID 25877470 DOI: 10.1042/BJ20150169  1
2015 Wang Y, Mitchell-Ryan S, Raghavan S, George C, Orr S, Hou Z, Matherly LH, Gangjee A. Novel 5-substituted pyrrolo[2,3-d]pyrimidines as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase and as potential antitumor agents. Journal of Medicinal Chemistry. 58: 1479-93. PMID 25602637 DOI: 10.1021/jm501787c  1
2014 Golani LK, George C, Zhao S, Raghavan S, Orr S, Wallace A, Wilson MR, Hou Z, Matherly LH, Gangjee A. Structure-activity profiles of novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolates with modified amino acids for cellular uptake by folate receptors α and β and the proton-coupled folate transporter. Journal of Medicinal Chemistry. 57: 8152-66. PMID 25234128 DOI: 10.1021/jm501113m  1
2014 Wilson MR, Hou Z, Matherly LH. Substituted cysteine accessibility reveals a novel transmembrane 2-3 reentrant loop and functional role for transmembrane domain 2 in the human proton-coupled folate transporter. The Journal of Biological Chemistry. 289: 25287-95. PMID 25053408 DOI: 10.1074/jbc.M114.578252  1
2014 Hou Z, Orr S, Matherly LH. Post-transcriptional regulation of the human reduced folate carrier as a novel adaptive mechanism in response to folate excess or deficiency. Bioscience Reports. 34. PMID 24949876 DOI: 10.1042/BSR20140065  1
2014 Hou Z, Matherly LH. Biology of the major facilitative folate transporters SLC19A1 and SLC46A1. Current Topics in Membranes. 73: 175-204. PMID 24745983 DOI: 10.1016/B978-0-12-800223-0.00004-9  1
2014 Patki M, Gadgeel S, Huang Y, McFall T, Shields AF, Matherly LH, Bepler G, Ratnam M. Glucocorticoid receptor status is a principal determinant of variability in the sensitivity of non-small-cell lung cancer cells to pemetrexed Journal of Thoracic Oncology : Official Publication of the International Association For the Study of Lung Cancer. 9: 519-526. PMID 24736075 DOI: 10.1097/JTO.0000000000000111  1
2014 Matherly LH, Wilson MR, Hou Z. The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 632-49. PMID 24396145 DOI: 10.1124/dmd.113.055723  1
2014 Hales EC, Taub JW, Matherly LH. New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia. Cellular Signalling. 26: 149-61. PMID 24140475 DOI: 10.1016/j.cellsig.2013.09.021  1
2013 Mitchell-Ryan S, Wang Y, Raghavan S, Ravindra MP, Hales E, Orr S, Cherian C, Hou Z, Matherly LH, Gangjee A. Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implications of inhibiting 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase to ampk activation and antitumor activity. Journal of Medicinal Chemistry. 56: 10016-32. PMID 24256410 DOI: 10.1021/jm401328u  1
2013 Wang Y, Cherian C, Orr S, Mitchell-Ryan S, Hou Z, Raghavan S, Matherly LH, Gangjee A. Tumor-targeting with novel non-benzoyl 6-substituted straight chain pyrrolo[2,3-d]pyrimidine antifolates via cellular uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis. Journal of Medicinal Chemistry. 56: 8684-95. PMID 24111942 DOI: 10.1021/jm401139z  1
2013 Caldwell JT, Edwards H, Dombkowski AA, Buck SA, Matherly LH, Ge Y, Taub JW. Overexpression of GATA1 confers resistance to chemotherapy in acute megakaryocytic Leukemia. Plos One. 8: e68601. PMID 23874683 DOI: 10.1371/journal.pone.0068601  1
2013 Hales EC, Orr SM, Larson Gedman A, Taub JW, Matherly LH. Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells. The Journal of Biological Chemistry. 288: 22836-48. PMID 23788636 DOI: 10.1074/jbc.M113.451625  1
2013 Cherian C, Kugel Desmoulin S, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Gangjee A, Matherly LH. Therapeutic targeting malignant mesothelioma with a novel 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate via its selective uptake by the proton-coupled folate transporter. Cancer Chemotherapy and Pharmacology. 71: 999-1011. PMID 23412628 DOI: 10.1007/s00280-013-2094-0  1
2012 Desmoulin SK, Hou Z, Gangjee A, Matherly LH. The human proton-coupled folate transporter: Biology and therapeutic applications to cancer. Cancer Biology & Therapy. 13: 1355-73. PMID 22954694 DOI: 10.4161/cbt.22020  1
2012 Desmoulin SK, Wang L, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH. Functional loss of the reduced folate carrier enhances the antitumor activities of novel antifolates with selective uptake by the proton-coupled folate transporter. Molecular Pharmacology. 82: 591-600. PMID 22740639 DOI: 10.1124/mol.112.079004  1
2012 Menter A, Thrash B, Cherian C, Matherly LH, Wang L, Gangjee A, Morgan JR, Maeda DY, Schuler AD, Kahn SJ, Zebala JA. Intestinal transport of aminopterin enantiomers in dogs and humans with psoriasis is stereoselective: evidence for a mechanism involving the proton-coupled folate transporter. The Journal of Pharmacology and Experimental Therapeutics. 342: 696-708. PMID 22653877 DOI: 10.1124/jpet.112.195479  1
2012 Xie C, Edwards H, Lograsso SB, Buck SA, Matherly LH, Taub JW, Ge Y. Valproic acid synergistically enhances the cytotoxicity of clofarabine in pediatric acute myeloid leukemia cells. Pediatric Blood & Cancer. 59: 1245-51. PMID 22488775 DOI: 10.1002/pbc.24152  1
2012 Wu J, Lorusso PM, Matherly LH, Li J. Implications of plasma protein binding for pharmacokinetics and pharmacodynamics of the γ-secretase inhibitor RO4929097. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 2066-79. PMID 22351688 DOI: 10.1158/1078-0432.CCR-11-2684  1
2012 Wang L, Cherian C, Kugel Desmoulin S, Mitchell-Ryan S, Hou Z, Matherly LH, Gangjee A. Synthesis and biological activity of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl regioisomers as inhibitors of de novo purine biosynthesis with selectivity for cellular uptake by high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier. Journal of Medicinal Chemistry. 55: 1758-70. PMID 22243528 DOI: 10.1021/jm201688n  1
2012 Hou Z, Desmoulin SK, Etnyre E, Olive M, Hsiung B, Cherian C, Wloszczynski PA, Moin K, Matherly LH. Identification and functional impact of homo-oligomers of the human proton-coupled folate transporter Journal of Biological Chemistry. 287: 4982-4995. PMID 22179615 DOI: 10.1074/jbc.M111.306860  1
2011 Xavier AC, Edwards H, Dombkowski AA, Balci TB, Berman JN, Dellaire G, Xie C, Buck SA, Matherly LH, Ge Y, Taub JW. A unique role of GATA1s in Down syndrome acute megakaryocytic leukemia biology and therapy. Plos One. 6: e27486. PMID 22110660 DOI: 10.1371/journal.pone.0027486  1
2011 Kugel Desmoulin S, Wang L, Hales E, Polin L, White K, Kushner J, Stout M, Hou Z, Cherian C, Gangjee A, Matherly LH. Therapeutic targeting of a novel 6-substituted pyrrolo [2,3-d]pyrimidine thienoyl antifolate to human solid tumors based on selective uptake by the proton-coupled folate transporter. Molecular Pharmacology. 80: 1096-107. PMID 21940787 DOI: 10.1124/mol.111.073833  1
2011 Wang L, Desmoulin SK, Cherian C, Polin L, White K, Kushner J, Fulterer A, Chang MH, Mitchell-Ryan S, Stout M, Romero MF, Hou Z, Matherly LH, Gangjee A. Synthesis, biological, and antitumor activity of a highly potent 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitor with proton-coupled folate transporter and folate receptor selectivity over the reduced folate carrier that inhibits β-glycinamide ribonucleotide formyltransferase. Journal of Medicinal Chemistry. 54: 7150-64. PMID 21879757 DOI: 10.1021/jm200739e  1
2010 Gadgeel SM, Cote ML, Schwartz AG, Matherly LH, Wozniak A, Bepler G. Parameters for individualizing systemic therapy in non-small cell lung cancer. Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. 13: 196-204. PMID 21051275 DOI: 10.1016/j.drup.2010.10.001  1
2010 Xie C, Edwards H, Xu X, Zhou H, Buck SA, Stout ML, Yu Q, Rubnitz JE, Matherly LH, Taub JW, Ge Y. Mechanisms of synergistic antileukemic interactions between valproic acid and cytarabine in pediatric acute myeloid leukemia. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 5499-510. PMID 20889917 DOI: 10.1158/1078-0432.CCR-10-1707  1
2010 Desmoulin SK, Wang Y, Wu J, Stout M, Hou Z, Fulterer A, Chang MH, Romero MF, Cherian C, Gangjee A, Matherly LH. Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. Molecular Pharmacology. 78: 577-87. PMID 20601456 DOI: 10.1124/mol.110.065896  1
2010 Hou Z, Wu J, Ye J, Cherian C, Matherly LH. Substrate-specific binding and conformational changes involving Ser313 and transmembrane domain 8 of the human reduced folate carrier, as determined by site-directed mutagenesis and protein cross-linking. The Biochemical Journal. 430: 265-74. PMID 20557288 DOI: 10.1042/BJ20100181  1
2010 Wang L, Cherian C, Desmoulin SK, Polin L, Deng Y, Wu J, Hou Z, White K, Kushner J, Matherly LH, Gangjee A. Synthesis and antitumor activity of a novel series of 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors and the proton-coupled folate transporter over the reduced folate carrier for cellular entry. Journal of Medicinal Chemistry. 53: 1306-18. PMID 20085328 DOI: 10.1021/jm9015729  1
2010 Hou Z, Cherian C, Drews J, Wu J, Matherly LH. Identification of the minimal functional unit of the homo-oligomeric human reduced folate carrier. The Journal of Biological Chemistry. 285: 4732-40. PMID 20018840 DOI: 10.1074/jbc.M109.086033  1
2010 Medyouf H, Gao X, Armstrong F, Gusscott S, Liu Q, Gedman AL, Matherly LH, Schultz KR, Pflumio F, You MJ, Weng AP. Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss. Blood. 115: 1175-84. PMID 20008304 DOI: 10.1182/blood-2009-04-214718  1
2009 Kato I, Badsha KZ, Land S, Nechvatal JM, Matherly LH, Tarca AL, Majumdar AP, Basson MD, Ram JL. DNA/RNA markers for colorectal cancer risk in preserved stool specimens: a pilot study. Tumori. 95: 753-61. PMID 20210241  1
2009 Edwards H, Xie C, LaFiura KM, Dombkowski AA, Buck SA, Boerner JL, Taub JW, Matherly LH, Ge Y. RUNX1 regulates phosphoinositide 3-kinase/AKT pathway: role in chemotherapy sensitivity in acute megakaryocytic leukemia. Blood. 114: 2744-52. PMID 19638627 DOI: 10.1182/blood-2008-09-179812  1
2009 Cabelof DC, Patel HV, Chen Q, van Remmen H, Matherly LH, Ge Y, Taub JW. Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome. Blood. 114: 2753-63. PMID 19633202 DOI: 10.1182/blood-2008-11-190330  1
2009 Deng Y, Zhou X, Kugel Desmoulin S, Wu J, Cherian C, Hou Z, Matherly LH, Gangjee A. Synthesis and biological activity of a novel series of 6-substituted thieno[2,3-d]pyrimidine antifolate inhibitors of purine biosynthesis with selectivity for high affinity folate receptors over the reduced folate carrier and proton-coupled folate transporter for cellular entry. Journal of Medicinal Chemistry. 52: 2940-51. PMID 19371039 DOI: 10.1021/jm8011323  1
2009 Larson Gedman A, Chen Q, Kugel Desmoulin S, Ge Y, LaFiura K, Haska CL, Cherian C, Devidas M, Linda SB, Taub JW, Matherly LH. The impact of NOTCH1, FBW7 and PTEN mutations on prognosis and downstream signaling in pediatric T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. Leukemia. 23: 1417-25. PMID 19340001 DOI: 10.1038/leu.2009.64  1
2009 Zhao R, Matherly LH, Goldman ID. Membrane transporters and folate homeostasis: intestinal absorption and transport into systemic compartments and tissues. Expert Reviews in Molecular Medicine. 11: e4. PMID 19173758 DOI: 10.1017/S1462399409000969  1
2009 Hou Z, Matherly LH. Oligomeric structure of the human reduced folate carrier: identification of homo-oligomers and dominant-negative effects on carrier expression and function. The Journal of Biological Chemistry. 284: 3285-93. PMID 19019821 DOI: 10.1074/jbc.M807206200  1
2008 Matherly LH, Hou Z. Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter. Vitamins and Hormones. 79: 145-84. PMID 18804694 DOI: 10.1016/S0083-6729(08)00405-6  1
2008 Deng Y, Wang Y, Cherian C, Hou Z, Buck SA, Matherly LH, Gangjee A. Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. Journal of Medicinal Chemistry. 51: 5052-63. PMID 18680275 DOI: 10.1021/jm8003366  1
2008 Lafiura KM, Edwards H, Taub JW, Matherly LH, Fontana JA, Mohamed AN, Ravindranath Y, Ge Y. Identification and characterization of novel AML1-ETO fusion transcripts in pediatric t(8;21) acute myeloid leukemia: A report from the Children's Oncology Group Oncogene. 27: 4933-4942. PMID 18469864 DOI: 10.1038/onc.2008.134  1
2008 Deng Y, Hou Z, Wang L, Cherian C, Wu J, Gangjee A, Matherly LH. Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition. Molecular Pharmacology. 73: 1274-81. PMID 18182479 DOI: 10.1124/mol.107.043190  1
2008 Nechvatal JM, Ram JL, Basson MD, Namprachan P, Niec SR, Badsha KZ, Matherly LH, Majumdar AP, Kato I. Fecal collection, ambient preservation, and DNA extraction for PCR amplification of bacterial and human markers from human feces. Journal of Microbiological Methods. 72: 124-32. PMID 18162191 DOI: 10.1016/j.mimet.2007.11.007  1
2008 Ge Y, LaFiura KM, Dombkowski AA, Chen Q, Payton SG, Buck SA, Salagrama S, Diakiw AE, Matherly LH, Taub JW. The role of the proto-oncogene ETS2 in acute megakaryocytic leukemia biology and therapy. Leukemia. 22: 521-9. PMID 18094719 DOI: 10.1038/sj.leu.2405066  1
2008 Patterson D, Graham C, Cherian C, Matherly LH. A humanized mouse model for the reduced folate carrier. Molecular Genetics and Metabolism. 93: 95-103. PMID 17983788 DOI: 10.1016/j.ymgme.2007.09.014  1
2007 Qiu A, Min SH, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly LH, Zhao R, Akabas MH, Goldman ID. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction. American Journal of Physiology. Cell Physiology. 293: C1669-78. PMID 17898134 DOI: 10.1152/ajpcell.00202.2007  1
2007 Lash LH, Putt DA, Xu F, Matherly LH. Role of rat organic anion transporter 3 (Oat3) in the renal basolateral transport of glutathione. Chemico-Biological Interactions. 170: 124-34. PMID 17719021 DOI: 10.1016/j.cbi.2007.07.004  1
2007 Lafiura KM, Bielawski DM, Posecion NC, Ostrea EM, Matherly LH, Taub JW, Ge Y. Association between prenatal pesticide exposures and the generation of leukemia-associated T(8;21). Pediatric Blood & Cancer. 49: 624-8. PMID 17610268 DOI: 10.1002/pbc.21283  1
2007 Matherly LH, Hou Z, Deng Y. Human reduced folate carrier: translation of basic biology to cancer etiology and therapy. Cancer Metastasis Reviews. 26: 111-28. PMID 17334909 DOI: 10.1007/s10555-007-9046-2  1
2007 Payton SG, Haska CL, Flatley RM, Ge Y, Matherly LH. Effects of 5' untranslated region diversity on the posttranscriptional regulation of the human reduced folate carrier. Biochimica Et Biophysica Acta. 1769: 131-8. PMID 17306382 DOI: 10.1016/j.bbaexp.2006.12.006  1
2007 Ge Y, Haska CL, LaFiura K, Devidas M, Linda SB, Liu M, Thomas R, Taub JW, Matherly LH. Prognostic role of the reduced folate carrier, the major membrane transporter for methotrexate, in childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 451-7. PMID 17255265 DOI: 10.1158/1078-0432.CCR-06-2145  1
2007 Matherly LH. Cancer and Metastasis Reviews: Preface Cancer and Metastasis Reviews. 26: 3-4. DOI: 10.1007/s10555-007-9040-8  1
2006 Hou Z, Ye J, Haska CL, Matherly LH. Transmembrane domains 4, 5, 7, 8, and 10 of the human reduced folate carrier are important structural or functional components of the transmembrane channel for folate substrates. The Journal of Biological Chemistry. 281: 33588-96. PMID 16923800 DOI: 10.1074/jbc.M607049200  1
2006 Cabelof DC, Ikeno Y, Nyska A, Busuttil RA, Anyangwe N, Vijg J, Matherly LH, Tucker JD, Wilson SH, Richardson A, Heydari AR. Haploinsufficiency in DNA polymerase beta increases cancer risk with age and alters mortality rate. Cancer Research. 66: 7460-5. PMID 16885342 DOI: 10.1158/0008-5472.CAN-06-1177  1
2006 Cabelof DC, Raffoul JJ, Ge Y, Van Remmen H, Matherly LH, Heydari AR. Age-related loss of the DNA repair response following exposure to oxidative stress. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 61: 427-34. PMID 16720738  1
2006 Gurdag S, Khandare J, Stapels S, Matherly LH, Kannan RM. Activity of dendrimer-methotrexate conjugates on methotrexate-sensitive and -resistant cell lines. Bioconjugate Chemistry. 17: 275-83. PMID 16536456 DOI: 10.1021/bc0501855  1
2006 Yang LV, Wan J, Ge Y, Fu Z, Kim SY, Fujiwara Y, Taub JW, Matherly LH, Eliason J, Li L. The GATA site-dependent hemogen promoter is transcriptionally regulated by GATA1 in hematopoietic and leukemia cells Leukemia. 20: 417-425. PMID 16437149 DOI: 10.1038/sj.leu.2404105  1
2006 Liu M, Ge Y, Payton SG, Aboukameel A, Buck S, Flatley RM, Haska C, Mohammad R, Taub JW, Matherly LH. Transcriptional regulation of the human reduced folate carrier in childhood acute lymphoblastic leukemia cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 608-16. PMID 16428507 DOI: 10.1158/1078-0432.CCR-05-1954  1
2006 Xu F, Putt DA, Matherly LH, Lash LH. Modulation of expression of rat mitochondrial 2-oxoglutarate carrier in NRK-52E cells alters mitochondrial transport and accumulation of glutathione and susceptibility to chemically induced apoptosis. The Journal of Pharmacology and Experimental Therapeutics. 316: 1175-86. PMID 16291728 DOI: 10.1124/jpet.105.094599  1
2006 Ge Y, Dombkowski AA, LaFiura KM, Tatman D, Yedidi RS, Stout ML, Buck SA, Massey G, Becton DL, Weinstein HJ, Ravindranath Y, Matherly LH, Taub JW. Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia. Blood. 107: 1570-81. PMID 16249385 DOI: 10.1182/blood-2005-06-2219  1
2005 Payton SG, Liu M, Ge Y, Matherly LH. Transcriptional regulation of the human reduced folate carrier A1/A2 promoter: Identification of critical roles for the USF and GATA families of transcription factors. Biochimica Et Biophysica Acta. 1731: 115-24. PMID 16225938 DOI: 10.1016/j.bbaexp.2005.08.010  1
2005 Hou Z, Stapels SE, Haska CL, Matherly LH. Localization of a substrate binding domain of the human reduced folate carrier to transmembrane domain 11 by radioaffinity labeling and cysteine-substituted accessibility methods. The Journal of Biological Chemistry. 280: 36206-13. PMID 16115875 DOI: 10.1074/jbc.M507295200  1
2005 Ge Y, Jensen TL, Tatman DA, Stout ML, Buck SA, Ravindranath Y, Matherly LH, Taub JW. Role of USF1 in the differential expression of the human deoxycytidine kinase gene in acute myeloid leukemia. Leukemia. 19: 677-9. PMID 15729384 DOI: 10.1038/sj.leu.2403666  1
2005 Ge Y, Stout ML, Tatman DA, Jensen TL, Buck S, Thomas RL, Ravindranath Y, Matherly LH, Taub JW. GATA1, cytidine deaminase, and the high cure rate of Down syndrome children with acute megakaryocytic leukemia. Journal of the National Cancer Institute. 97: 226-31. PMID 15687366 DOI: 10.1093/jnci/dji026  1
2005 Payton SG, Whetstine JR, Ge Y, Matherly LH. Transcriptional regulation of the human reduced folate carrier promoter C: synergistic transactivation by Sp1 and C/EBP beta and identification of a downstream repressor. Biochimica Et Biophysica Acta. 1727: 45-57. PMID 15652157 DOI: 10.1016/j.bbaexp.2004.11.006  1
2005 Liu M, Ge Y, Cabelof DC, Aboukameel A, Heydari AR, Mohammad R, Matherly LH. Structure and regulation of the murine reduced folate carrier gene: identification of four noncoding exons and promoters and regulation by dietary folates. The Journal of Biological Chemistry. 280: 5588-97. PMID 15579899 DOI: 10.1074/jbc.M412662200  1
2004 Witt TL, Stapels SE, Matherly LH. Restoration of transport activity by co-expression of human reduced folate carrier half-molecules in transport-impaired K562 cells: localization of a substrate binding domain to transmembrane domains 7-12. The Journal of Biological Chemistry. 279: 46755-63. PMID 15337749 DOI: 10.1074/jbc.M408696200  1
2004 Taub JW, Mundschau G, Ge Y, Poulik JM, Qureshi F, Jensen T, James SJ, Matherly LH, Wechsler J, Crispino JD. Prenatal origin of GATA1 mutations may be an initiating step in the development of megakaryocytic leukemia in Down syndrome. Blood. 104: 1588-9. PMID 15317736 DOI: 10.1182/blood-2004-04-1563  1
2004 Flatley RM, Payton SG, Taub JW, Matherly LH. Primary acute lymphoblastic leukemia cells use a novel promoter and 5'noncoding exon for the human reduced folate carrier that encodes a modified carrier translated from an upstream translational start. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 5111-22. PMID 15297414 DOI: 10.1158/1078-0432.CCR-04-0116  1
2004 Liu M, Whetstine JR, Payton SG, Ge Y, Flatley RM, Matherly LH. Roles of USF, Ikaros and Sp proteins in the transcriptional regulation of the human reduced folate carrier B promoter. The Biochemical Journal. 383: 249-57. PMID 15214842 DOI: 10.1042/BJ20040414  1
2004 Kaufman Y, Drori S, Cole PD, Kamen BA, Sirota J, Ifergan I, Arush MW, Elhasid R, Sahar D, Kaspers GJ, Jansen G, Matherly LH, Rechavi G, Toren A, Assaraf YG. Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia. Cancer. 100: 773-82. PMID 14770434 DOI: 10.1002/cncr.20018  1
2004 Ge Y, Jensen TL, Stout ML, Flatley RM, Grohar PJ, Ravindranath Y, Matherly LH, Taub JW. The role of cytidine deaminase and GATA1 mutations in the increased cytosine arabinoside sensitivity of Down syndrome myeloblasts and leukemia cell lines. Cancer Research. 64: 728-35. PMID 14744791 DOI: 10.1158/0008-5472.CAN-03-2456  1
2004 Cao W, Matherly LH. Analysis of the membrane topology for transmembrane domains 7-12 of the human reduced folate carrier by scanning cysteine accessibility methods. The Biochemical Journal. 378: 201-6. PMID 14602046 DOI: 10.1042/BJ20031288  1
2004 Matherly LH. Human reduced folate carrier gene and transcript variants: Functional, physiologic, and pharmacologic consequences Current Pharmacogenomics. 2: 287-298. DOI: 10.2174/1570160043377547  1
2003 Lubec G, Bajo M, Cheon MS, Bajova H, Matherly LH. Increased expression of human reduced folate carrier in fetal Down syndrome brain Journal of Neural Transmission, Supplement. 95-103. PMID 15068242  1
2003 Ge Y, Jensen TL, Matherly LH, Taub JW. Physical and functional interactions between USF and Sp1 proteins regulate human deoxycytidine kinase promoter activity. The Journal of Biological Chemistry. 278: 49901-10. PMID 14514691 DOI: 10.1074/jbc.M305085200  1
2003 Li M, Zhou JY, Ge Y, Matherly LH, Wu GS. The phosphatase MKP1 is a transcriptional target of p53 involved in cell cycle regulation. The Journal of Biological Chemistry. 278: 41059-68. PMID 12890671 DOI: 10.1074/jbc.M307149200  1
2003 Matherly LH, Goldman DI. Membrane transport of folates. Vitamins and Hormones. 66: 403-56. PMID 12852262 DOI: 10.1016/S0083-6729(03)01012-4  1
2003 Cao W, Matherly LH. Characterization of a cysteine-less human reduced folate carrier: localization of a substrate-binding domain by cysteine-scanning mutagenesis and cysteine accessibility methods. The Biochemical Journal. 374: 27-36. PMID 12749765 DOI: 10.1042/BJ20030301  1
2003 Ge Y, Jensen TL, Matherly LH, Taub JW. Transcriptional regulation of the cystathionine-beta -synthase gene in Down syndrome and non-Down syndrome megakaryocytic leukemia cell lines. Blood. 101: 1551-7. PMID 12393509 DOI: 10.1182/blood-2002-07-2337  1
2003 Liu XY, Witt TL, Matherly LH. Restoration of high-level transport activity by human reduced folate carrier/ThTr1 thiamine transporter chimaeras: role of the transmembrane domain 6/7 linker region in reduced folate carrier function. The Biochemical Journal. 369: 31-7. PMID 12227830 DOI: 10.1042/BJ20020419  1
2002 Witt TL, Matherly LH. Identification of lysine-411 in the human reduced folate carrier as an important determinant of substrate selectivity and carrier function by systematic site-directed mutagenesis. Biochimica Et Biophysica Acta. 1567: 56-62. PMID 12488038 DOI: 10.1016/S0005-2736(02)00583-7  1
2002 Gifford AJ, Haber M, Witt TL, Whetstine JR, Taub JW, Matherly LH, Norris MD. Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. Leukemia. 16: 2379-87. PMID 12454742 DOI: 10.1038/sj.leu.2402655  1
2002 Ge Y, Jensen TL, Matherly LH, Taub JW. Synergistic regulation of human cystathionine-beta-synthase-1b promoter by transcription factors NF-YA isoforms and Sp1. Biochimica Et Biophysica Acta. 1579: 73-80. PMID 12427542 DOI: 10.1016/S0167-4781(02)00509-2  1
2002 Ge Y, Jensen T, James SJ, Becton DL, Massey GV, Weinstein HJ, Ravindranath Y, Matherly LH, Taub JW. High frequency of the 844ins68 cystathionine-β-synthase gene variant in Down syndrome children with acute myeloid leukemia [7] Leukemia. 16: 2339-2341. PMID 12399985 DOI: 10.1038/sj.leu.2402705  1
2002 Lash LH, Putt DA, Matherly LH. Protection of NRK-52E cells, a rat renal proximal tubular cell line, from chemical-induced apoptosis by overexpression of a mitochondrial glutathione transporter. The Journal of Pharmacology and Experimental Therapeutics. 303: 476-86. PMID 12388626 DOI: 10.1124/jpet.102.040220  1
2002 Whetstine JR, Witt TL, Matherly LH. The human reduced folate carrier gene is regulated by the AP2 and sp1 transcription factor families and a functional 61-base pair polymorphism. The Journal of Biological Chemistry. 277: 43873-80. PMID 12228234 DOI: 10.1074/jbc.M208296200  1
2002 Liu XY, Matherly LH. Analysis of membrane topology of the human reduced folate carrier protein by hemagglutinin epitope insertion and scanning glycosylation insertion mutagenesis. Biochimica Et Biophysica Acta. 1564: 333-42. PMID 12175915 DOI: 10.1016/S0005-2736(02)00467-4  1
2002 Whetstine JR, Flatley RM, Matherly LH. The human reduced folate carrier gene is ubiquitously and differentially expressed in normal human tissues: identification of seven non-coding exons and characterization of a novel promoter. The Biochemical Journal. 367: 629-40. PMID 12144527 DOI: 10.1042/BJ20020512  1
2002 Taub JW, Matherly LH, Ravindranath Y, Kaspers GJ, Rots MG, Zantwijk CH. Polymorphisms in methylenetetrahydrofolate reductase and methotrexate sensitivity in childhood acute lymphoblastic leukemia. Leukemia. 16: 764-5. PMID 11960366 DOI: 10.1038/sj.leu.2402428  1
2002 Taub JW, Konrad MA, Ge Y, Naber JM, Scott JS, Matherly LH, Ravindranath Y. High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia. Blood. 99: 2992-6. PMID 11929791 DOI: 10.1182/blood.V99.8.2992  1
2002 Sampath J, Adachi M, Hatse S, Naesens L, Balzarini J, Flatley RM, Matherly LH, Schuetz JD. Role of MRP4 and MRP5 in biology and chemotherapy Aaps Pharmsci. 4.  1
2001 Whetstine JR, Gifford AJ, Witt T, Liu XY, Flatley RM, Norris M, Haber M, Taub JW, Ravindranath Y, Matherly LH. Single nucleotide polymorphisms in the human reduced folate carrier: characterization of a high-frequency G/A variant at position 80 and transport properties of the His(27) and Arg(27) carriers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 7: 3416-22. PMID 11705857  1
2001 Ge Y, Matherly LH, Taub JW. Transcriptional Regulation of Cell-specific Expression of the Human Cystathionine β-Synthase Gene by Differential Binding of Sp1/Sp3 to the -1b Promoter Journal of Biological Chemistry. 276: 43570-43579. PMID 11562358 DOI: 10.1074/jbc.M104930200  1
2001 Matherly LH. Molecular and cellular biology of the human reduced folate carrier Progress in Nucleic Acid Research and Molecular Biology. 67: 131-162. PMID 11525381  1
2001 Liu XY, Matherly LH. Functional interactions between arginine-133 and aspartate-88 in the human reduced folate carrier: Evidence for a charge-pair association Biochemical Journal. 358: 511-516. PMID 11513752 DOI: 10.1042/0264-6021:3580511  1
2001 Ge Y, Konrad MA, Matherly LH, Taub JW. Transcriptional regulation of the human cystathionine β-synthase - 1b basal promoter: Synergistic transactivation by transcription factors NF-Y and Sp1/Sp3 Biochemical Journal. 357: 97-105. PMID 11415440 DOI: 10.1042/0264-6021:3570097  1
2001 Shah SJ, Taub JW, Witt TL, Pollock BH, Ding BC, Moore DS, Amylon M, Pullen J, Ravindranath Y, Matherly LH. Relationship of p15 and p16 gene alterations to elevated dihydrofolate reductase in childhood acute lymphoblastic leukaemia. British Journal of Haematology. 113: 746-56. PMID 11380466 DOI: 10.1046/j.1365-2141.2001.02775.x  1
2001 Ding BC, Witt TL, Hukku B, Heng H, Zhang L, Matherly LH. Association of deletions and translocation of the reduced folate carrier gene with profound loss of gene expression in methotrexate-resistant K562 human erythroleukemia cells. Biochemical Pharmacology. 61: 665-75. PMID 11266651 DOI: 10.1016/S0006-2952(01)00535-4  1
2001 Ding BC, Whetstine JR, Witt TL, Schuetz JD, Matherly LH. Repression of human reduced folate carrier gene expression by wild type p53. The Journal of Biological Chemistry. 276: 8713-9. PMID 11106643 DOI: 10.1074/jbc.M005248200  1
2001 Whetstine JR, Matherly LH. The basal promoters for the human reduced folate carrier gene are regulated by a GC-box and a cAMP-response element/AP-1-like element: Basis for tissue-specific gene expression Journal of Biological Chemistry. 276: 6350-6358. PMID 11078737 DOI: 10.1074/jbc.M008074200  1
2000 Taub JW, Huang X, Ge Y, Dutcher JA, Stout ML, Mohammad RM, Ravindranath Y, Matherly LH. Cystathionine-beta-synthase cDNA transfection alters the sensitivity and metabolism of 1-beta-D-arabinofuranosylcytosine in CCRF-CEM leukemia cells in vitro and in vivo: a model of leukemia in Down syndrome. Cancer Research. 60: 6421-6. PMID 11103808  1
2000 Said HM, Chatterjee N, Ul Haq R, Subramanian VS, Ortiz A, Matherly LH, Sirotnak FM, Halsted C, Rubin SA. Adaptive regulation of intestinal folate uptake: Effect of dietary folate deficiency American Journal of Physiology - Cell Physiology. 279. PMID 11078704  1
1999 Matherly LH, Taub JW. Molecular and cellular correlates of methotrexate response in childhood acute lymphoblastic leukemia Leukemia and Lymphoma. 35: 1-20. PMID 10512159  1
1999 Taub JW, Huang X, Matherly LH, Stout ML, Buck SA, Massey GV, Becton DL, Chang MN, Weinstein HJ, Ravindranath Y. Expression of chromosome 21-localized genes in acute myeloid leukemia: Differences between Down syndrome and non-Down syndrome blast cells and relationship to in vitro sensitivity to cytosine arabinoside and daunorubicin Blood. 94: 1393-1400. PMID 10438727  1
1999 Wong SC, Zhang L, Witt TL, Proefke SA, Bhushan A, Matherly LH. Impaired membrane transport in methotrexate-resistant CCRF-CEM cells involves early translation termination and increased turnover of a mutant reduced folate carrier Journal of Biological Chemistry. 274: 10388-10394. PMID 10187828 DOI: 10.1074/jbc.274.15.10388  1
1998 Zhang L, Wong SC, Matherly LH. Structure and organization of the human reduced folate carrier gene Biochimica Et Biophysica Acta - Gene Structure and Expression. 1442: 389-393. PMID 9804996 DOI: 10.1016/S0167-4781(98)00168-7  1
1998 Wong SC, Zhang L, Proefke SA, Matherly LH. Effects of the loss of capacity for N-glycosylation on the transport activity and cellular localization of the human reduced folate carrier Biochimica Et Biophysica Acta - Biomembranes. 1375: 6-12. PMID 9767079 DOI: 10.1016/S0005-2736(98)00118-7  1
1998 Gifford AJ, Kavallaris M, Madafiglio J, Matherly LH, Stewart BW, Haber M, Norris MD. P-glycoprotein-mediated methotrexate resistance in CCRF-CEM sublines deficient in methotrexate accumulation due to a point mutation in the reduced folate carrier gene. International Journal of Cancer. Journal International Du Cancer. 78: 176-81. PMID 9754649 DOI: 10.1002/(SICI)1097-0215(19981005)78:2<176::AID-IJC10>3.0.CO;2-9  1
1998 Zhang L, Taub JW, Williamson M, Wong SC, Hukku B, Pullen J, Ravindranath Y, Matherly LH. Reduced folate carrier gene expression in childhood acute lymphoblastic leukemia: Relationship to immunophenotype and ploidy Clinical Cancer Research. 4: 2169-2177. PMID 9748136  1
1998 Zhang L, Wong SC, Matherly LH. Transcript heterogeneity of the human reduced folate carrier results from the use of multiple promoters and variable splicing of alternative upstream exons Biochemical Journal. 332: 773-780. PMID 9620882  1
1998 Wong SC, Zhang L, Proefke SA, Hukku B, Matherly LH. Gene amplification and increased expression of the reduced folate carrier in transport elevated K562 cells Biochemical Pharmacology. 55: 1135-1138. PMID 9605439 DOI: 10.1016/S0006-2952(97)00639-4  1
1997 Jolivet J, Faure MP, Wong SC, Taub JW, Matherly LH. Confocal microscopy visualization of antifolate uptake by the reduced folate carrier in human leukaemic cells British Journal of Cancer. 76: 734-738. PMID 9310238  1
1997 Matherly LH, Taub JW, Wong SC, Simpson PM, Ekizian R, Buck S, Williamson M, Amylon M, Pullen J, Camitta B, Ravindranath Y. Increased frequency of expression of elevated dihydrofolate reductasc in T-cell versus B-precursor acute lymphoblastic leukemia in children Blood. 90: 578-589. PMID 9226157  1
1997 Wong SC, McQuade R, Proefke SA, Bhushan A, Matherly LH. Human K562 transfectants expressing high levels of reduced folate carrier but exhibiting low transport activity Biochemical Pharmacology. 53: 199-206. PMID 9037252 DOI: 10.1016/S0006-2952(96)00710-1  1
1996 Miller BE, Matherly LH, Lehotan M, Heppner GH. Rates of development of methotrexate resistance in heterogeneous mouse mammary tumor cell cultures Journal of Experimental Therapeutics and Oncology. 1: 30-38. PMID 9414386  1
1996 Matherly LH, Taub JW. Methotrexate pharmacology and resistance in childhood acute lymphoblastic leukemia Leukemia and Lymphoma. 21: 359-368. PMID 9172800  1
1996 Taub JW, Matherly LH, Stout ML, Buck SA, Gurney JG, Ravindranath Y. Enhanced metabolism of 1-beta-D-arabinofuranosylcytosine in Down syndrome cells: a contributing factor to the superior event free survival of Down syndrome children with acute myeloid leukemia. Blood. 87: 3395-403. PMID 8605357  1
1995 Matherly LH, Taub JW, Ravindranath Y, Proefke SA, Wong SC, Gimotty P, Buck S, Wright JE, Rosowsky A. Elevated dihydrofolate reductase and impaired methotrexate transport as elements in methotrexate resistance in childhood acute lymphoblastic leukemia. Blood. 85: 500-9. PMID 7812005  1
1995 Wong SC, Proefke SA, Bhushan A, Matherly LH. Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cell Journal of Biological Chemistry. 270: 17468-17475. PMID 7615551  1
1994 Matherly LH, Angeles SM. Role of N-glycosylation in the structure and function of the methotrexate membrane transporter from CCRF-CEM human lymphoblastic leukemia cells Biochemical Pharmacology. 47: 1094-1098. PMID 8147910 DOI: 10.1016/0006-2952(94)90423-5  1
1994 Rosowsky A, Bader H, Wright JE, Keyomarsi K, Matherly LH. Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin. Journal of Medicinal Chemistry. 37: 2167-74. PMID 8035423 DOI: 10.1021/jm00040a008  1
1993 Matherly LH, Angeles SM. Determinants of the disparate antitumor effects of (6R)5,10-dideaza- 5,6,7,8-tetrahydrofolate and methotrexate toward methotrexate resistant CCRF- CEM cells, characterized by severely impaired antifolate membrane transport Advances in Experimental Medicine and Biology. 338: 783-786. PMID 8304229  1
1993 Matherly LH, Angeles SM, McGuire JJ. Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired antifolate membrane transport Biochemical Pharmacology. 46: 2185-2195. PMID 7506026 DOI: 10.1016/0006-2952(93)90608-Y  1
1992 Matherly LH, Angeles SM, Czajkowski CA. Characterization of transport-mediated methotrexate resistance in human tumor cells with antibodies to the membrane carrier for methotrexate and tetrahydrofolate cofactors. The Journal of Biological Chemistry. 267: 23253-60. PMID 1429671  1
1991 Matherly LH, Czajkowski CA, Angeles SM. Identification of a highly glycosylated methotrexate membrane carrier in K562 human erythroleukemia cells up-regulated for tetrahydrofolate cofactor and methotrexate transport. Cancer Research. 51: 3420-6. PMID 2054782  1
1991 Kavallaris M, Haber M, Norris MD, Matherly LH, Stewart BW. Characterization of Mechanisms Mediating Drug Resistance in Human Leukemic Cells Selected with High Concentration Methotrexate Pteridines. 3: 119-121. DOI: 10.1515/pteridines.1991.3.12.119  1
1990 Matherly LH, Muench SP. Evidence for a localized conversion of endogenous tetrahydrofolate cofactors to dihydrofolate as an important element in antifolate action in murine leukemia cells Biochemical Pharmacology. 39: 2005-2014. PMID 2141258 DOI: 10.1016/0006-2952(90)90622-R  1
1990 Matherly LH, Czajkowski CA, Muench SP, Psiakis JT. Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro. Cancer Research. 50: 3262-9. PMID 2139802  1
1989 Schuetz JD, Westin EH, Matherly LH, Pincus R, Swerdlow PS, Goldman ID. Membrane protein changes in an L1210 leukemia cell line with a translocation defect in the methotrexate-tetrahydrofolate cofactor transport carrier Journal of Biological Chemistry. 264: 16261-16267. PMID 2777791  1
1989 Matherly LH, Schuetz JD, Westin E, Goldman ID. A method for the synchronization of cultured cells with aphidicolin: Application to the large-scale synchronization of L1210 cells and the study of the cell cycle regulation of thymidylate synthase and dihydrofolate reductase Analytical Biochemistry. 182: 338-345. PMID 2514611 DOI: 10.1016/0003-2697(89)90605-2  1
1988 Schuetz JD, Matherly LH, Westin EH, Goldman ID. Evidence for a functional defect in the translocation of the methotrexate transport carrier in a methotrexate-resistant murine L1210 leukemia cell line Journal of Biological Chemistry. 263: 9840-9847. PMID 2838483  1
1987 Matherly LH, Barlowe CK, Phillips VM, Goldman ID. The effects of 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue Journal of Biological Chemistry. 262: 710-717. PMID 2948949  1
1987 Goldman ID, Matherly LH. Biochemical factors in the selectivity of leucovorin rescue: Selective inhibition of leucovorin reactivation of dihydrofolate reductase and leucovorin utilization in purine and pyrimidine biosynthesis by methotrexate and dihydrofolate polyglutamates Nci Monographs. 17-26. PMID 2448654  1
1987 Matherly LH, Seither RL, David Goldman I. Metabolism of the diaminoantifolates: Biosynthesis and pharmacology of the 7-hydroxyl and polyglutamyl metabolites of methotrexate and related antifolates Pharmacology and Therapeutics. 35: 27-56. PMID 2447596 DOI: 10.1016/0163-7258(87)90104-5  1
1986 Matherly LH, Barlowe CK, Goldman ID. Antifolate Polyglutamylation and Competitive Drug Displacement at Dihydrofolate Reductase as Important Elements in Leucovorin Rescue in L1210 Cells Cancer Research. 46: 588-593. PMID 2416428  1
1985 Matherly LH, Voss MK, Anderson LA, Fry DW, Goldman ID. Enhanced Polyglutamylation of Aminopterin Relative to Methotrexate in the Ehrlich Ascites Tumor Cell in vitro Cancer Research. 45: 1073-1078. PMID 2578870  1
1985 Goldman ID, Matherly LH. The cellular pharmacology of methotrexate Pharmacology and Therapeutics. 28: 77-102. PMID 2414788 DOI: 10.1016/0163-7258(85)90083-X  1
1985 Matherly LH, Barlowe CK, Banks WL, Goldman ID. Polyglutamation of 2,4-diaminoantifolates as a critical determinant of leucovorin (LCV) rescue Proceedings of the American Association For Cancer Research 1
1984 Fabre G, Fabre I, Matherly LH, Cano JP, Goldman ID. Synthesis and properties of 7-hydroxymethotrexate polyglutamyl derivatives in Ehrlich ascites tumor cells in vitro Journal of Biological Chemistry. 259: 5066-5072. PMID 6715337  1
1984 Fabre G, Matherly LH, Fabre I, Cano JP, Goldman ID. Interactions Between 7-Hydroxymethotrexate and Methotrexate at the Cellular Level in the Ehrlich Ascites Tumor in Vitro Cancer Research. 44: 970-975. PMID 6692419  1
1984 Matherly LH, Anderson LA, Goldman ID. Role of the Cellular Oxidation-Reduction State in Methotrexate Binding to Dihydrofolate Reductase and Dissociation Induced by Reduced Folates Cancer Research. 44: 2325-2330. PMID 6609765  1
1984 Fabre G, Matherly LH, Goldman ID. Pathways for the synthesis of 7-hydroxymethotrexate polyglutamyl derivatives Federation Proceedings. 43.  1
1984 Matherly LH, Anderson LA, Goldman ID. Polyglutamylation of aminopterin precedes binding to dihydrofolate reductase in Ehrlich tumor cells Federation Proceedings. 43.  1
1983 Favre R, Catalin J, Cano JP, Fabre G, Matherly LH. In Vitro Formation of Polyglutamyl Derivatives of Methotrexate and 7-Hydroxymethotrexate in Human Lymphoblastic Leukemia Cells Cancer Research. 43: 4648-4652. PMID 6192907  1
1983 Matherly LH, Fry DW, Goldman ID. Role of Methotrexate Polyglutamylation and Cellular Energy Metabolism in Inhibition of Methotrexate Binding to Dihydrofolate Reductase by 5-Formyltetrahydrofolate in Ehrlich Ascites Tumor Cells in Vitro Cancer Research. 43: 2694-2699. PMID 6189586  1
1983 Matherly LH, Phillips AT. Identification of the enol tautomer of imidazolone propionate as the urocanase reaction product Archives of Biochemistry and Biophysics. 220: 314-317. PMID 6131645 DOI: 10.1016/0003-9861(83)90416-2  1
1982 Matherly LH, Johnson KA, Phillips AT. Transient-state kinetic analysis of urocanase Biochemistry. 21: 2795-2798. PMID 6124274  1
1982 Matherly LH, DeBrosse CW, Phillips AT. A covalent nicotinamide adenine dinucleotide intermediate in the urocanase reaction Biochemistry. 21: 2789-2794. PMID 6124273  1
1981 Egan RM, Matherly LH, Phillips AT. Mechanism of urocanase as studied by deuterium isotope effects and labeling patterns Biochemistry. 20: 132-137. PMID 6110440  1
1980 Matherly LH, Phillips AT. Substrate-mediated inactivation of urocanase from Pseudomonas putida. Evidence for an essential sulfhydryl group Biochemistry. 19: 5814-5818. PMID 6109547  1
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