Year |
Citation |
Score |
2023 |
Ghouil R, Miron S, Sato K, Ristic D, van Rossum-Fikkert SE, Legrand P, Ouldali M, Winter JM, Ropars V, David G, Arteni AA, Wyman C, Knipscheer P, Kanaar R, Zelensky AN, et al. BRCA2-HSF2BP oligomeric ring disassembly by BRME1 promotes homologous recombination. Science Advances. 9: eadi7352. PMID 37889963 DOI: 10.1126/sciadv.adi7352 |
0.391 |
|
2023 |
Heemskerk T, van de Kamp G, Essers J, Kanaar R, Paul MW. Multi-scale cellular imaging of DNA double strand break repair. Dna Repair. 131: 103570. PMID 37734176 DOI: 10.1016/j.dnarep.2023.103570 |
0.404 |
|
2021 |
van de Kamp G, Heemskerk T, Kanaar R, Essers J. DNA Double Strand Break Repair Pathways in Response to Different Types of Ionizing Radiation. Frontiers in Genetics. 12: 738230. PMID 34659358 DOI: 10.3389/fgene.2021.738230 |
0.318 |
|
2021 |
Paul MW, Sidhu A, Liang Y, van Rossum-Fikkert SE, Odijk H, Zelensky AN, Kanaar R, Wyman C. Role of BRCA2 DNA-binding and C-terminal domain on its mobility and conformation in DNA repair. Elife. 10. PMID 34254584 DOI: 10.7554/eLife.67926 |
0.407 |
|
2021 |
Paul MW, Sidhu A, Liang Y, van Rossum-Fikkert SE, Odijk H, Zelensky AN, Kanaar R, Wyman C. Role of BRCA2 DNA-binding and C-terminal domain on its mobility and conformation in DNA repair. Elife. 10. PMID 34254584 DOI: 10.7554/eLife.67926 |
0.407 |
|
2020 |
Reuvers TGA, Kanaar R, Nonnekens J. DNA Damage-Inducing Anticancer Therapies: From Global to Precision Damage. Cancers. 12. PMID 32731592 DOI: 10.3390/cancers12082098 |
0.349 |
|
2020 |
Sato K, Brandsma I, van Rossum-Fikkert SE, Verkaik N, Oostra AB, Dorsman JC, van Gent DC, Knipscheer P, Kanaar R, Zelensky AN. HSF2BP negatively regulates homologous recombination in DNA interstrand crosslink repair. Nucleic Acids Research. PMID 31960047 DOI: 10.1093/Nar/Gkz1219 |
0.396 |
|
2020 |
Zelensky AN, Schoonakker M, Brandsma I, Tijsterman M, van Gent DC, Essers J, Kanaar R. Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner. Plos Genetics. 16: e1008550. PMID 31945059 DOI: 10.1371/journal.pgen.1008550 |
0.307 |
|
2019 |
Mardenborough YSN, Nitsenko K, Laffeber C, Duboc C, Sahin E, Quessada-Vial A, Winterwerp HHK, Sixma TK, Kanaar R, Friedhoff P, Strick TR, Lebbink JHG. The unstructured linker arms of MutL enable GATC site incision beyond roadblocks during initiation of DNA mismatch repair. Nucleic Acids Research. PMID 31598722 DOI: 10.1093/Nar/Gkz834 |
0.484 |
|
2019 |
van den Tempel N, Zelensky AN, Odijk H, Laffeber C, Schmidt CK, Brandsma I, Demmers J, Krawczyk PM, Kanaar R. On the Mechanism of Hyperthermia-Induced BRCA2 Protein Degradation. Cancers. 11. PMID 30650591 DOI: 10.3390/cancers11010097 |
0.32 |
|
2018 |
van der Zon NL, Kanaar R, Wyman C. Variation in RAD51 details a hub of functions: opportunities to advance cancer diagnosis and therapy. F1000research. 7. PMID 30271574 DOI: 10.12688/F1000Research.15650.2 |
0.355 |
|
2018 |
van der Pluijm I, Burger J, van Heijningen PM, IJpma A, van Vliet N, Milanese C, Schoonderwoerd K, Sluiter W, Ringuette LJ, Dekkers DHW, Que I, Kaijzel EL, Te Riet L, MacFarlane E, Das D, ... ... Kanaar R, et al. Decreased mitochondrial respiration in aneurysmal aortas of Fibulin-4 mutant mice is linked to PGC1A regulation. Cardiovascular Research. PMID 29931197 DOI: 10.1093/Cvr/Cvy150 |
0.323 |
|
2018 |
Paul MW, Zelensky AN, Wyman C, Kanaar R. Single-Molecule Dynamics and Localization of DNA Repair Proteins in Cells. Methods in Enzymology. 600: 375-406. PMID 29458767 DOI: 10.1016/Bs.Mie.2017.11.015 |
0.319 |
|
2017 |
Zelensky AN, Schimmel J, Kool H, Kanaar R, Tijsterman M. Inactivation of Pol θ and C-NHEJ eliminates off-target integration of exogenous DNA. Nature Communications. 8: 66. PMID 28687761 DOI: 10.1038/s41467-017-00124-3 |
0.3 |
|
2017 |
Oei AL, van Leeuwen CM, Ahire VR, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJA, Crezee J, Kok HP, Krawczyk PM, Kanaar R, Franken NAP. Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia. Oncotarget. PMID 28427225 DOI: 10.18632/oncotarget.15922 |
0.334 |
|
2017 |
Sánchez H, Paul MW, Grosbart M, van Rossum-Fikkert SE, Lebbink JH, Kanaar R, Houtsmuller AB, Wyman C. Architectural plasticity of human BRCA2-RAD51 complexes in DNA break repair. Nucleic Acids Research. PMID 28168276 DOI: 10.1093/Nar/Gkx084 |
0.42 |
|
2016 |
van Gent DC, Kanaar R. Exploiting DNA repair defects for novel cancer therapies. Molecular Biology of the Cell. 27: 2145-8. PMID 27418635 DOI: 10.1091/mbc.E15-10-0698 |
0.31 |
|
2016 |
Hermans N, Laffeber C, Cristovão M, Artola-Borán M, Mardenborough Y, Ikpa P, Jaddoe A, Winterwerp HH, Wyman C, Jiricny J, Kanaar R, Friedhoff P, Lebbink JH. Dual daughter strand incision is processive and increases the efficiency of DNA mismatch repair. Nucleic Acids Research. PMID 27174933 DOI: 10.1093/Nar/Gkw411 |
0.46 |
|
2016 |
Harnicek D, Kampmann E, Lauber K, Hennel R, Cardoso Martins AS, Guo Y, Belka C, Mörtl S, Gallmeier E, Kanaar R, Mansmann U, Hucl T, Lindner LH, Hiddemann W, Issels RD. Hyperthermia adds to trabectedin effectiveness and thermal enhancement is associated with BRCA2 degradation and impairment of DNA homologous recombination repair. International Journal of Cancer. PMID 26933761 DOI: 10.1002/ijc.30070 |
0.34 |
|
2015 |
Tham KC, Kanaar R, Lebbink JH. Mismatch repair and homeologous recombination. Dna Repair. PMID 26739221 DOI: 10.1016/j.dnarep.2015.11.010 |
0.449 |
|
2015 |
Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, de Gruiter HM, van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C. BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells. The Journal of Cell Biology. 208: 857. PMID 25778924 DOI: 10.1083/Jcb.20140501402182015C |
0.426 |
|
2015 |
Uringa EJ, Baldeyron C, Odijk H, Wassenaar E, van Cappellen WA, Maas A, Hoeijmakers JH, Baarends WM, Kanaar R, Essers J. A mRad51-GFP antimorphic allele affects homologous recombination and DNA damage sensitivity. Dna Repair. 25: 27-40. PMID 25463395 DOI: 10.1016/j.dnarep.2014.11.002 |
0.438 |
|
2014 |
Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, de Gruiter HM, van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C. BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells. The Journal of Cell Biology. 207: 599-613. PMID 25488918 DOI: 10.1083/jcb.201405014 |
0.426 |
|
2014 |
Zelensky A, Kanaar R, Wyman C. Mediators of homologous DNA pairing. Cold Spring Harbor Perspectives in Biology. 6: a016451. PMID 25301930 DOI: 10.1101/Cshperspect.A016451 |
0.489 |
|
2013 |
Shima H, Suzuki H, Sun J, Kono K, Shi L, Kinomura A, Horikoshi Y, Ikura T, Ikura M, Kanaar R, Igarashi K, Saitoh H, Kurumizaka H, Tashiro S. Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage. Journal of Cell Science. 126: 5284-92. PMID 24046452 DOI: 10.1242/jcs.133744 |
0.496 |
|
2013 |
Tham KC, Hermans N, Winterwerp HH, Cox MM, Wyman C, Kanaar R, Lebbink JH. Mismatch repair inhibits homeologous recombination via coordinated directional unwinding of trapped DNA structures. Molecular Cell. 51: 326-37. PMID 23932715 DOI: 10.1016/J.Molcel.2013.07.008 |
0.472 |
|
2013 |
Sanchez H, Kertokalio A, van Rossum-Fikkert S, Kanaar R, Wyman C. Combined optical and topographic imaging reveals different arrangements of human RAD54 with presynaptic and postsynaptic RAD51-DNA filaments. Proceedings of the National Academy of Sciences of the United States of America. 110: 11385-90. PMID 23801766 DOI: 10.1073/Pnas.1306467110 |
0.416 |
|
2013 |
Zelensky AN, Sanchez H, Ristic D, Vidic I, van Rossum-Fikkert SE, Essers J, Wyman C, Kanaar R. Caffeine suppresses homologous recombination through interference with RAD51-mediated joint molecule formation. Nucleic Acids Research. 41: 6475-89. PMID 23666627 DOI: 10.1093/Nar/Gkt375 |
0.43 |
|
2013 |
Kikuchi K, Narita T, Pham VT, Iijima J, Hirota K, Keka IS, Mohiuddin, Okawa K, Hori T, Fukagawa T, Essers J, Kanaar R, Whitby MC, Sugasawa K, Taniguchi Y, et al. Structure-specific endonucleases xpf and mus81 play overlapping but essential roles in DNA repair by homologous recombination. Cancer Research. 73: 4362-71. PMID 23576554 DOI: 10.1158/0008-5472.CAN-12-3154 |
0.332 |
|
2013 |
Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA. UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway. Journal of Cell Science. 126: 1923-30. PMID 23447674 DOI: 10.1242/jcs.118265 |
0.318 |
|
2013 |
Bergs JW, Krawczyk PM, Borovski T, ten Cate R, Rodermond HM, Stap J, Medema JP, Haveman J, Essers J, van Bree C, Stalpers LJ, Kanaar R, Aten JA, Franken NA. Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining. Dna Repair. 12: 38-45. PMID 23237939 DOI: 10.1016/j.dnarep.2012.10.008 |
0.302 |
|
2012 |
Eppink B, Krawczyk PM, Stap J, Kanaar R. Hyperthermia-induced DNA repair deficiency suggests novel therapeutic anti-cancer strategies. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 28: 509-17. PMID 22834701 DOI: 10.3109/02656736.2012.695427 |
0.319 |
|
2012 |
Krawczyk PM, Borovski T, Stap J, Cijsouw T, ten Cate R, Medema JP, Kanaar R, Franken NA, Aten JA. Chromatin mobility is increased at sites of DNA double-strand breaks. Journal of Cell Science. 125: 2127-33. PMID 22328517 DOI: 10.1242/jcs.089847 |
0.337 |
|
2011 |
Levy-Barda A, Lerenthal Y, Davis AJ, Chung YM, Essers J, Shao Z, van Vliet N, Chen DJ, Hu MC, Kanaar R, Ziv Y, Shiloh Y. Involvement of the nuclear proteasome activator PA28γ in the cellular response to DNA double-strand breaks. Cell Cycle (Georgetown, Tex.). 10: 4300-10. PMID 22134242 DOI: 10.4161/cc.10.24.18642 |
0.443 |
|
2011 |
Eppink B, Tafel AA, Hanada K, van Drunen E, Hickson ID, Essers J, Kanaar R. The response of mammalian cells to UV-light reveals Rad54-dependent and independent pathways of homologous recombination. Dna Repair. 10: 1095-105. PMID 21885354 DOI: 10.1016/j.dnarep.2011.08.006 |
0.37 |
|
2011 |
Tanori M, Pasquali E, Leonardi S, Giardullo P, Di Majo V, Taccioli G, Essers J, Kanaar R, Mullenders LH, Atkinson MJ, Mancuso M, Saran A, Pazzaglia S. Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum. Oncogene. 30: 4740-9. PMID 21602895 DOI: 10.1038/onc.2011.178 |
0.346 |
|
2011 |
Holthausen JT, van Loenhout MT, Sanchez H, Ristic D, van Rossum-Fikkert SE, Modesti M, Dekker C, Kanaar R, Wyman C. Effect of the BRCA2 CTRD domain on RAD51 filaments analyzed by an ensemble of single molecule techniques. Nucleic Acids Research. 39: 6558-67. PMID 21576230 DOI: 10.1093/nar/gkr295 |
0.392 |
|
2011 |
Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, ... ... Kanaar R, et al. Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks. Molecular Cell. 41: 529-42. PMID 21362549 DOI: 10.1016/J.Molcel.2011.02.015 |
0.394 |
|
2011 |
Agarwal S, van Cappellen WA, Guénolé A, Eppink B, Linsen SE, Meijering E, Houtsmuller A, Kanaar R, Essers J. ATP-dependent and independent functions of Rad54 in genome maintenance. The Journal of Cell Biology. 192: 735-50. PMID 21357745 DOI: 10.1083/jcb.201011025 |
0.462 |
|
2011 |
Ristic D, Kanaar R, Wyman C. Visualizing RAD51-mediated joint molecules: implications for recombination mechanism and the effect of sequence heterology. Nucleic Acids Research. 39: 155-67. PMID 20817928 DOI: 10.1093/Nar/Gkq766 |
0.368 |
|
2011 |
Moyal L, Lerenthal Y, Gana-Weisz M, Mass G, So S, Wang SY, Eppink B, Chung YM, Shalev G, Shema E, Shkedy D, Smorodinsky NI, van Vliet N, Kuster B, Mann M, ... ... Kanaar R, et al. Requirement of ATM-Dependent Monoubiquitylation of Histone H2B for Timely Repair of DNA Double-Strand Breaks Molecular Cell. 42: 137. DOI: 10.1016/j.molcel.2011.03.009 |
0.365 |
|
2011 |
Candelli A, Holthausen J, Modesti M, Kanaar R, Wyman C, Peterman E, Wuite GJ. Resolving RAD51 Filament Nucleation, Extension and Disassembly on ssDNA and dsDNA One Protein at a Time Biophysical Journal. 100: 240a. DOI: 10.1016/J.Bpj.2010.12.1530 |
0.4 |
|
2011 |
Eppink B, Essers J, Kanaar R. Interplay and Quality Control of DNA Damage Repair Mechanisms Genome Organization and Function in the Cell Nucleus. 395-415. DOI: 10.1002/9783527639991.ch16 |
0.324 |
|
2010 |
Sun J, Oma Y, Harata M, Kono K, Shima H, Kinomura A, Ikura T, Suzuki H, Mizutani S, Kanaar R, Tashiro S. ATM modulates the loading of recombination proteins onto a chromosomal translocation breakpoint hotspot. Plos One. 5: e13554. PMID 21048951 DOI: 10.1371/journal.pone.0013554 |
0.306 |
|
2010 |
Holthausen JT, Wyman C, Kanaar R. Regulation of DNA strand exchange in homologous recombination. Dna Repair. 9: 1264-72. PMID 20971042 DOI: 10.1016/J.Dnarep.2010.09.014 |
0.494 |
|
2010 |
Warmerdam DO, Kanaar R, Smits VA. Differential Dynamics of ATR-Mediated Checkpoint Regulators. Journal of Nucleic Acids. 2010. PMID 20847938 DOI: 10.4061/2010/319142 |
0.358 |
|
2010 |
Chu WK, Hanada K, Kanaar R, Hickson ID. BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Oncogene. 29: 4705-14. PMID 20531307 DOI: 10.1038/Onc.2010.214 |
0.351 |
|
2010 |
De Vlaminck I, Vidic I, van Loenhout MT, Kanaar R, Lebbink JH, Dekker C. Torsional regulation of hRPA-induced unwinding of double-stranded DNA. Nucleic Acids Research. 38: 4133-42. PMID 20197317 DOI: 10.1093/nar/gkq067 |
0.43 |
|
2010 |
Wang H, Zhang X, Wang P, Yu X, Essers J, Chen D, Kanaar R, Takeda S, Wang Y. Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation. Nucleic Acids Research. 38: 3245-51. PMID 20150414 DOI: 10.1093/Nar/Gkq069 |
0.387 |
|
2010 |
Warmerdam DO, Kanaar R. Dealing with DNA damage: relationships between checkpoint and repair pathways. Mutation Research. 704: 2-11. PMID 20006736 DOI: 10.1016/j.mrrev.2009.12.001 |
0.425 |
|
2009 |
Soria G, Belluscio L, van Cappellen WA, Kanaar R, Essers J, Gottifredi V. DNA damage induced Pol eta recruitment takes place independently of the cell cycle phase. Cell Cycle (Georgetown, Tex.). 8: 3340-8. PMID 19806028 |
0.371 |
|
2009 |
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Molecular and Cellular Biology. 29: 6427-37. PMID 19805513 DOI: 10.1128/Mcb.00086-09 |
0.411 |
|
2009 |
Brugmans L, Verkaik NS, Kunen M, van Drunen E, Williams BR, Petrini JH, Kanaar R, Essers J, van Gent DC. NBS1 cooperates with homologous recombination to counteract chromosome breakage during replication. Dna Repair. 8: 1363-70. PMID 19782649 DOI: 10.1016/J.Dnarep.2009.09.002 |
0.345 |
|
2009 |
Muñoz IM, Hain K, Déclais AC, Gardiner M, Toh GW, Sanchez-Pulido L, Heuckmann JM, Toth R, Macartney T, Eppink B, Kanaar R, Ponting CP, Lilley DM, Rouse J. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair. Molecular Cell. 35: 116-27. PMID 19595721 DOI: 10.1016/J.Molcel.2009.06.020 |
0.42 |
|
2009 |
van Loenhout MT, van der Heijden T, Kanaar R, Wyman C, Dekker C. Dynamics of RecA filaments on single-stranded DNA. Nucleic Acids Research. 37: 4089-99. PMID 19429893 DOI: 10.1093/Nar/Gkp326 |
0.375 |
|
2009 |
Warmerdam DO, Freire R, Kanaar R, Smits VA. Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress. Cell Cycle (Georgetown, Tex.). 8: 1765-74. PMID 19411845 |
0.381 |
|
2009 |
van der Linden E, Sanchez H, Kinoshita E, Kanaar R, Wyman C. RAD50 and NBS1 form a stable complex functional in DNA binding and tethering. Nucleic Acids Research. 37: 1580-8. PMID 19151086 DOI: 10.1093/Nar/Gkn1072 |
0.416 |
|
2009 |
Kirshner M, Rathavs M, Nizan A, Essers J, Kanaar R, Shiloh Y, Barzilai A. Analysis of the relationships between ATM and the Rad54 paralogs involved in homologous recombination repair. Dna Repair. 8: 253-61. PMID 19061978 DOI: 10.1016/j.dnarep.2008.11.005 |
0.367 |
|
2009 |
van Mameren J, Modesti M, Kanaar R, Wyman C, Peterman EJ, Wuite GJ. Counting RAD51 proteins disassembling from nucleoprotein filaments under tension. Nature. 457: 745-8. PMID 19060884 DOI: 10.1038/Nature07581 |
0.381 |
|
2009 |
Budzowska M, Kanaar R. Mechanisms of dealing with DNA damage-induced replication problems. Cell Biochemistry and Biophysics. 53: 17-31. PMID 19034694 DOI: 10.1007/s12013-008-9039-y |
0.386 |
|
2008 |
Medhurst AL, Warmerdam DO, Akerman I, Verwayen EH, Kanaar R, Smits VA, Lakin ND. ATR and Rad17 collaborate in modulating Rad9 localisation at sites of DNA damage. Journal of Cell Science. 121: 3933-40. PMID 19020305 DOI: 10.1242/jcs.033688 |
0.408 |
|
2008 |
Krawczyk PM, Stap J, Hoebe RA, van Oven CH, Kanaar R, Aten JA. Analysis of the mobility of DNA double-strand break-containing chromosome domains in living mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 463: 309-20. PMID 18951175 DOI: 10.1007/978-1-59745-406-3_19 |
0.375 |
|
2008 |
van der Heijden T, Modesti M, Hage S, Kanaar R, Wyman C, Dekker C. Homologous recombination in real time: DNA strand exchange by RecA. Molecular Cell. 30: 530-8. PMID 18498754 DOI: 10.1016/J.Molcel.2008.03.010 |
0.434 |
|
2008 |
Wyman C, Warmerdam DO, Kanaar R. From DNA end chemistry to cell-cycle response: the importance of structure, even when it's broken. Molecular Cell. 30: 5-6. PMID 18406321 DOI: 10.1016/J.Molcel.2008.03.007 |
0.382 |
|
2008 |
Kanaar R, Wyman C, Rothstein R. Quality control of DNA break metabolism: in the 'end', it's a good thing. The Embo Journal. 27: 581-8. PMID 18285819 DOI: 10.1038/Emboj.2008.11 |
0.4 |
|
2007 |
Modesti M, Budzowska M, Baldeyron C, Demmers JA, Ghirlando R, Kanaar R. RAD51AP1 is a structure-specific DNA binding protein that stimulates joint molecule formation during RAD51-mediated homologous recombination. Molecular Cell. 28: 468-81. PMID 17996710 DOI: 10.1016/j.molcel.2007.08.025 |
0.464 |
|
2007 |
Hanada K, Budzowska M, Davies SL, van Drunen E, Onizawa H, Beverloo HB, Maas A, Essers J, Hickson ID, Kanaar R. The structure-specific endonuclease Mus81 contributes to replication restart by generating double-strand DNA breaks. Nature Structural & Molecular Biology. 14: 1096-104. PMID 17934473 DOI: 10.1038/nsmb1313 |
0.433 |
|
2007 |
van der Heijden T, Seidel R, Modesti M, Kanaar R, Wyman C, Dekker C. Real-time assembly and disassembly of human RAD51 filaments on individual DNA molecules. Nucleic Acids Research. 35: 5646-57. PMID 17709342 DOI: 10.1093/Nar/Gkm629 |
0.391 |
|
2007 |
Dinant C, de Jager M, Essers J, van Cappellen WA, Kanaar R, Houtsmuller AB, Vermeulen W. Activation of multiple DNA repair pathways by sub-nuclear damage induction methods. Journal of Cell Science. 120: 2731-40. PMID 17646676 DOI: 10.1242/jcs.004523 |
0.326 |
|
2007 |
Modesti M, Ristic D, van der Heijden T, Dekker C, van Mameren J, Peterman EJ, Wuite GJ, Kanaar R, Wyman C. Fluorescent human RAD51 reveals multiple nucleation sites and filament segments tightly associated along a single DNA molecule. Structure (London, England : 1993). 15: 599-609. PMID 17502105 DOI: 10.1016/J.Str.2007.04.003 |
0.448 |
|
2007 |
Brugmans L, Kanaar R, Essers J. Analysis of DNA double-strand break repair pathways in mice. Mutation Research. 614: 95-108. PMID 16797606 DOI: 10.1016/j.mrfmmm.2006.01.022 |
0.399 |
|
2007 |
Van Der Heijden T, Moreno-Herrero F, Kanaar R, Wyman C, Dekker C. AFM tip-induced dissociation of RecA-dsDNA filaments Nano Letters. 7: 1112. DOI: 10.1021/Nl070385K |
0.304 |
|
2006 |
Hanada K, Budzowska M, Modesti M, Maas A, Wyman C, Essers J, Kanaar R. The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks. The Embo Journal. 25: 4921-32. PMID 17036055 DOI: 10.1038/Sj.Emboj.7601344 |
0.468 |
|
2006 |
Mohd-Sarip A, van der Knaap JA, Wyman C, Kanaar R, Schedl P, Verrijzer CP. Architecture of a polycomb nucleoprotein complex. Molecular Cell. 24: 91-100. PMID 17018295 DOI: 10.1016/J.Molcel.2006.08.007 |
0.385 |
|
2006 |
Mameren Jv, Modesti M, Kanaar R, Wyman C, Wuite GJ, Peterman EJ. Dissecting elastic heterogeneity along DNA molecules coated partly with Rad51 using concurrent fluorescence microscopy and optical tweezers. Biophysical Journal. 91: L78-80. PMID 16920830 DOI: 10.1529/Biophysj.106.089466 |
0.336 |
|
2006 |
Wyman C, Kanaar R. DNA double-strand break repair: all's well that ends well. Annual Review of Genetics. 40: 363-83. PMID 16895466 DOI: 10.1146/Annurev.Genet.40.110405.090451 |
0.424 |
|
2006 |
Eppink B, Wyman C, Kanaar R. Multiple interlinked mechanisms to circumvent DNA replication roadblocks. Experimental Cell Research. 312: 2660-5. PMID 16859683 DOI: 10.1016/J.Yexcr.2006.06.011 |
0.404 |
|
2006 |
Agarwal S, Tafel AA, Kanaar R. DNA double-strand break repair and chromosome translocations. Dna Repair. 5: 1075-81. PMID 16798112 DOI: 10.1016/j.dnarep.2006.05.029 |
0.388 |
|
2006 |
Essers J, Houtsmuller AB, Kanaar R. Analysis of DNA recombination and repair proteins in living cells by photobleaching microscopy. Methods in Enzymology. 408: 463-85. PMID 16793387 DOI: 10.1016/S0076-6879(06)08029-3 |
0.453 |
|
2006 |
Wesoly J, Agarwal S, Sigurdsson S, Bussen W, Van Komen S, Qin J, van Steeg H, van Benthem J, Wassenaar E, Baarends WM, Ghazvini M, Tafel AA, Heath H, Galjart N, Essers J, ... ... Kanaar R, et al. Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosis. Molecular and Cellular Biology. 26: 976-89. PMID 16428451 DOI: 10.1128/Mcb.26.3.976-989.2006 |
0.393 |
|
2005 |
Garinis GA, Mitchell JR, Moorhouse MJ, Hanada K, de Waard H, Vandeputte D, Jans J, Brand K, Smid M, van der Spek PJ, Hoeijmakers JH, Kanaar R, van der Horst GT. Transcriptome analysis reveals cyclobutane pyrimidine dimers as a major source of UV-induced DNA breaks. The Embo Journal. 24: 3952-62. PMID 16252008 DOI: 10.1038/sj.emboj.7600849 |
0.363 |
|
2005 |
Essers J, Theil AF, Baldeyron C, van Cappellen WA, Houtsmuller AB, Kanaar R, Vermeulen W. Nuclear dynamics of PCNA in DNA replication and repair. Molecular and Cellular Biology. 25: 9350-9. PMID 16227586 DOI: 10.1128/MCB.25.21.9350-9359.2005 |
0.457 |
|
2005 |
Moreno-Herrero F, de Jager M, Dekker NH, Kanaar R, Wyman C, Dekker C. Mesoscale conformational changes in the DNA-repair complex Rad50/Mre11/Nbs1 upon binding DNA. Nature. 437: 440-3. PMID 16163361 DOI: 10.1038/Nature03927 |
0.375 |
|
2005 |
Ristic D, Modesti M, van der Heijden T, van Noort J, Dekker C, Kanaar R, Wyman C. Human Rad51 filaments on double- and single-stranded DNA: correlating regular and irregular forms with recombination function. Nucleic Acids Research. 33: 3292-302. PMID 15944450 DOI: 10.1093/Nar/Gki640 |
0.44 |
|
2005 |
van Veelen LR, Essers J, van de Rakt MW, Odijk H, Pastink A, Zdzienicka MZ, Paulusma CC, Kanaar R. Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52. Mutation Research. 574: 34-49. PMID 15914205 DOI: 10.1016/j.mrfmmm.2005.01.020 |
0.425 |
|
2005 |
van Veelen LR, Cervelli T, van de Rakt MW, Theil AF, Essers J, Kanaar R. Analysis of ionizing radiation-induced foci of DNA damage repair proteins. Mutation Research. 574: 22-33. PMID 15914204 DOI: 10.1016/j.mrfmmm.2005.01.019 |
0.413 |
|
2005 |
van der Heijden T, van Noort J, van Leest H, Kanaar R, Wyman C, Dekker NH, Dekker N, Dekker C. Torque-limited RecA polymerization on dsDNA. Nucleic Acids Research. 33: 2099-105. PMID 15824062 DOI: 10.1093/Nar/Gki512 |
0.388 |
|
2005 |
Adams DJ, van der Weyden L, Gergely FV, Arends MJ, Ng BL, Tannahill D, Kanaar R, Markus A, Morris BJ, Bradley A. BRCTx is a novel, highly conserved RAD18-interacting protein. Molecular and Cellular Biology. 25: 779-88. PMID 15632077 DOI: 10.1128/Mcb.25.2.779-788.2005 |
0.337 |
|
2005 |
Beerens N, Hoeijmakers JH, Kanaar R, Vermeulen W, Wyman C. The CSB protein actively wraps DNA. The Journal of Biological Chemistry. 280: 4722-9. PMID 15548521 DOI: 10.1074/Jbc.M409147200 |
0.449 |
|
2004 |
Budzowska M, Jaspers I, Essers J, de Waard H, van Drunen E, Hanada K, Beverloo B, Hendriks RW, de Klein A, Kanaar R, Hoeijmakers JH, Maas A. Mutation of the mouse Rad17 gene leads to embryonic lethality and reveals a role in DNA damage-dependent recombination. The Embo Journal. 23: 3548-58. PMID 15297881 DOI: 10.1038/sj.emboj.7600353 |
0.393 |
|
2004 |
Lau A, Kanaar R, Jackson SP, O'Connor MJ. Suppression of retroviral infection by the RAD52 DNA repair protein. The Embo Journal. 23: 3421-9. PMID 15297876 DOI: 10.1038/sj.emboj.7600348 |
0.426 |
|
2004 |
Wyman C, Kanaar R. Homologous recombination: down to the wire. Current Biology : Cb. 14: R629-31. PMID 15296782 DOI: 10.1016/J.Cub.2004.07.049 |
0.421 |
|
2004 |
Wyman C, Ristic D, Kanaar R. Homologous recombination-mediated double-strand break repair. Dna Repair. 3: 827-33. PMID 15279767 DOI: 10.1016/J.Dnarep.2004.03.037 |
0.429 |
|
2004 |
Niedernhofer LJ, Odijk H, Budzowska M, van Drunen E, Maas A, Theil AF, de Wit J, Jaspers NG, Beverloo HB, Hoeijmakers JH, Kanaar R. The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Molecular and Cellular Biology. 24: 5776-87. PMID 15199134 DOI: 10.1128/Mcb.24.13.5776-5787.2004 |
0.394 |
|
2004 |
Couëdel C, Mills KD, Barchi M, Shen L, Olshen A, Johnson RD, Nussenzweig A, Essers J, Kanaar R, Li GC, Alt FW, Jasin M. Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells. Genes & Development. 18: 1293-304. PMID 15175261 DOI: 10.1101/Gad.1209204 |
0.353 |
|
2004 |
Mills KD, Ferguson DO, Essers J, Eckersdorff M, Kanaar R, Alt FW. Rad54 and DNA Ligase IV cooperate to maintain mammalian chromatid stability. Genes & Development. 18: 1283-92. PMID 15175260 DOI: 10.1101/Gad.1204304 |
0.407 |
|
2004 |
de Jager M, Trujillo KM, Sung P, Hopfner KP, Carney JP, Tainer JA, Connelly JC, Leach DR, Kanaar R, Wyman C. Differential arrangements of conserved building blocks among homologs of the Rad50/Mre11 DNA repair protein complex. Journal of Molecular Biology. 339: 937-49. PMID 15165861 DOI: 10.1016/J.Jmb.2004.04.014 |
0.32 |
|
2003 |
Abraham J, Lemmers B, Hande MP, Moynahan ME, Chahwan C, Ciccia A, Essers J, Hanada K, Chahwan R, Khaw AK, McPherson P, Shehabeldin A, Laister R, Arrowsmith C, Kanaar R, et al. Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells. The Embo Journal. 22: 6137-47. PMID 14609959 DOI: 10.1093/Emboj/Cdg580 |
0.414 |
|
2003 |
Modesti M, Junop MS, Ghirlando R, van de Rakt M, Gellert M, Yang W, Kanaar R. Tetramerization and DNA ligase IV interaction of the DNA double-strand break repair protein XRCC4 are mutually exclusive. Journal of Molecular Biology. 334: 215-28. PMID 14607114 DOI: 10.1016/J.Jmb.2003.09.031 |
0.448 |
|
2003 |
Ristic D, Modesti M, Kanaar R, Wyman C. Rad52 and Ku bind to different DNA structures produced early in double-strand break repair. Nucleic Acids Research. 31: 5229-37. PMID 12954758 DOI: 10.1093/Nar/Gkg729 |
0.464 |
|
2003 |
Tan TL, Kanaar R, Wyman C. Rad54, a Jack of all trades in homologous recombination. Dna Repair. 2: 787-94. PMID 12826279 DOI: 10.1016/S1568-7864(03)00070-3 |
0.402 |
|
2003 |
van Noort J, van Der Heijden T, de Jager M, Wyman C, Kanaar R, Dekker C. The coiled-coil of the human Rad50 DNA repair protein contains specific segments of increased flexibility. Proceedings of the National Academy of Sciences of the United States of America. 100: 7581-6. PMID 12805565 DOI: 10.1073/Pnas.1330706100 |
0.316 |
|
2003 |
Savouret C, Brisson E, Essers J, Kanaar R, Pastink A, te Riele H, Junien C, Gourdon G. CTG repeat instability and size variation timing in DNA repair-deficient mice. The Embo Journal. 22: 2264-73. PMID 12727892 DOI: 10.1093/emboj/cdg202 |
0.333 |
|
2002 |
Essers J, Hendriks RW, Wesoly J, Beerens CE, Smit B, Hoeijmakers JH, Wyman C, Dronkert ML, Kanaar R. Analysis of mouse Rad54 expression and its implications for homologous recombination. Dna Repair. 1: 779-93. PMID 12531026 DOI: 10.1016/S1568-7864(02)00110-6 |
0.495 |
|
2002 |
de Jager M, Wyman C, van Gent DC, Kanaar R. DNA end-binding specificity of human Rad50/Mre11 is influenced by ATP. Nucleic Acids Research. 30: 4425-31. PMID 12384589 DOI: 10.1093/Nar/Gkf574 |
0.38 |
|
2002 |
Difilippantonio MJ, Petersen S, Chen HT, Johnson R, Jasin M, Kanaar R, Ried T, Nussenzweig A. Evidence for replicative repair of DNA double-strand breaks leading to oncogenic translocation and gene amplification Journal of Experimental Medicine. 196: 469-480. PMID 12186839 DOI: 10.1084/Jem.20020851 |
0.38 |
|
2002 |
Godthelp BC, Wiegant WW, van Duijn-Goedhart A, Schärer OD, van Buul PP, Kanaar R, Zdzienicka MZ. Mammalian Rad51C contributes to DNA cross-link resistance, sister chromatid cohesion and genomic stability. Nucleic Acids Research. 30: 2172-82. PMID 12000837 DOI: 10.1093/Nar/30.10.2172 |
0.377 |
|
2002 |
Essers J, Houtsmuller AB, Van Veelen L, Paulusma C, Nigg AL, Pastink A, Vermeulen W, Hoeijmakers JHJ, Kanaar R. Nuclear dynamics of RAD52 group homologous recombination proteins in response to DNA damage Embo Journal. 21: 2030-2037. PMID 11953322 DOI: 10.1093/emboj/21.8.2030 |
0.47 |
|
2001 |
De Jager M, Van Noort J, Van Gent DC, Dekker C, Kanaar R, Wyman C. Human Rad50/Mre11 is a flexible complex that can tether DNA ends Molecular Cell. 8: 1129-1135. PMID 11741547 DOI: 10.1016/S1097-2765(01)00381-1 |
0.328 |
|
2001 |
Niedernhofer LJ, Essers J, Weeda G, Beverloo B, De Wit J, Muijtjens M, Odijk H, Hoeijmakers JHJ, Kanaar R. The structure-specific endonuclease Ercc1-Xpf is required for targeted gene replacement in embryonic stem cells Embo Journal. 20: 6540-6549. PMID 11707424 DOI: 10.1093/Emboj/20.22.6540 |
0.357 |
|
2001 |
Dronkert MLG, Kanaar R. Repair of DNA interstrand cross-links Mutation Research - Dna Repair. 486: 217-247. PMID 11516927 DOI: 10.1016/S0921-8777(01)00092-1 |
0.382 |
|
2001 |
Ristic D, Wyman C, Paulusma C, Kanaar R. The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA Proceedings of the National Academy of Sciences of the United States of America. 98: 8454-8460. PMID 11459989 DOI: 10.1073/Pnas.151056798 |
0.463 |
|
2001 |
Van Gent DC, Hoeijmakers JHJ, Kanaar R. Chromosomal stability and the DNA double-stranded break connection Nature Reviews Genetics. 2: 196-206. PMID 11256071 DOI: 10.1038/35056049 |
0.347 |
|
2001 |
De Jager M, Dronkert MLG, Modesti M, Beerens CEMT, Kanaar R, Van Gent DC. DNA-binding and strand-annealing activities of human Mre11: Implications for its roles in DNA double-strand break repair pathways Nucleic Acids Research. 29: 1317-1325. PMID 11238998 |
0.475 |
|
2000 |
Citterio E, Van Den Boom V, Schnitzler G, Kanaar R, Bonte E, Kingston RE, Hoeijmakers JH, Vermeulen W. ATP-dependent chromatin remodeling by the Cockayne syndrome B DNA repair-transcription-coupling factor. Molecular and Cellular Biology. 20: 7643-53. PMID 11003660 DOI: 10.1128/Mcb.20.20.7643-7653.2000 |
0.383 |
|
2000 |
Takata M, Sasaki MS, Sonoda E, Fukushima T, Morrison C, Albala JS, Swagemakers SMA, Kanaar R, Thompson LH, Takeda S. The Rad51 paralog Rad51B promotes homologous recombinational repair Molecular and Cellular Biology. 20: 6476-6482. PMID 10938124 DOI: 10.1128/MCB.20.17.6476-6482.2000 |
0.348 |
|
2000 |
Dronkert MLG, De Wit J, Boeve M, Vasconcelos ML, Van Steeg H, Tan TLR, Hoeijmakers JHJ, Kanaar R. Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C Molecular and Cellular Biology. 20: 4553-4561. PMID 10848582 DOI: 10.1128/MCB.20.13.4553-4561.2000 |
0.398 |
|
2000 |
Dronkert ML, Beverloo HB, Johnson RD, Hoeijmakers JH, Jasin M, Kanaar R. Mouse RAD54 affects DNA double-strand break repair and sister chromatid exchange. Molecular and Cellular Biology. 20: 3147-56. PMID 10757799 DOI: 10.1128/Mcb.20.9.3147-3156.2000 |
0.382 |
|
2000 |
Essers J, Van Steeg H, De Wit J, Swagemakers SMA, Vermeij M, Hoeijmakers JHJ, Kanaar R. Homologous and non-homologous recombination differentially affect DNA damage repair in mice Embo Journal. 19: 1703-1710. PMID 10747037 |
0.364 |
|
1999 |
Bennink ML, Schärer OD, Kanaar R, Sakata-Sogawa K, Schins JM, Kanger JS, De Grooth BG, Greve J. Single-molecule manipulation of double-stranded DNA using optical tweezers: Interaction studies of DNA with RecA and YOYO-1 Cytometry. 36: 200-208. PMID 10404969 DOI: 10.1002/(SICI)1097-0320(19990701)36:3<200::AID-CYTO9>3.0.CO;2-T |
0.373 |
|
1999 |
Tan TL, Essers J, Citterio E, Swagemakers SM, de Wit J, Benson FE, Hoeijmakers JH, Kanaar R. Mouse Rad54 affects DNA conformation and DNA-damage-induced Rad51 foci formation. Current Biology : Cb. 9: 325-8. PMID 10209103 DOI: 10.1016/S0960-9822(99)80142-0 |
0.45 |
|
1998 |
Kanaar R, Hoeijmakers JHJ, Van Gent DC. Molecular mechanisms of DNA double-strand break repair Trends in Cell Biology. 8: 483-489. PMID 9861670 DOI: 10.1016/S0962-8924(98)01383-X |
0.408 |
|
1998 |
Swagemakers SMA, Essers J, De Wit J, Hoeijmakers JHJ, Kanaar R. The human Rad54 recombinational DNA repair protein is a double-stranded DNA-dependent ATPase Journal of Biological Chemistry. 273: 28292-28297. PMID 9774452 DOI: 10.1074/jbc.273.43.28292 |
0.458 |
|
1997 |
Kanaar R, Hoeijmakers JH. Recombination and joining: different means to the same ends Genes and Function. 1: 165-174. PMID 9680292 |
0.395 |
|
1997 |
Essers J, Hendriks RW, Swagemakers SMA, Troelstra C, De Wit J, Bootsma D, Hoeijmakers JHJ, Kanaar R. Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination Cell. 89: 195-204. PMID 9108475 DOI: 10.1016/S0092-8674(00)80199-3 |
0.378 |
|
1996 |
Lehmann AR, Bridges BA, Hanawalt PC, Johnson RT, Kanaar R, Krokan HE, Kyrtopoulos S, Lambert B, Melton DW, Moustacchi E, Natarajan AT, Radman M, Sarasin A, Seeberg E, Smerdon MJ, et al. Workshop on processing of DNA damage. Mutation Research. 364: 245-70. PMID 8960136 DOI: 10.1016/S0921-8777(96)00037-7 |
0.345 |
|
1996 |
Kanaar R, Troelstra C, Swagemakers SMA, Essers J, Smit B, Franssen JH, Pastink A, Bezzubova OY, Buerstedde JM, Clever B, Heyer WD, Hoeijmakers JHJ. Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: Evidence for functional conservation Current Biology. 6: 828-838. PMID 8805304 DOI: 10.1016/S0960-9822(02)00606-1 |
0.341 |
|
1996 |
Benjamin KR, Abola AP, Kanaar R, Cozzarelli NR. Contributions of supercoiling to Tn3 resolvase and phage Mu Gin site-specific recombination. Journal of Molecular Biology. 256: 50-65. PMID 8609613 DOI: 10.1006/Jmbi.1996.0067 |
0.413 |
|
1994 |
Crisona NJ, Kanaar R, Gonzalez TN, Zechiedrich EL, Klippel A, Cozzarelli NR. Processive recombination by wild-type gin and an enhancer-independent mutant. Insight into the mechanisms of recombination selectivity and strand exchange. Journal of Molecular Biology. 243: 437-57. PMID 7966272 DOI: 10.1006/Jmbi.1994.1671 |
0.419 |
|
1994 |
Chen J, Kanaar R, Cozzarelli NR. The Sep1 strand exchange protein from Saccharomyces cerevisiae promotes a paranemic joint between homologous DNA molecules. Genes & Development. 8: 1356-66. PMID 7926736 DOI: 10.1101/Gad.8.11.1356 |
0.432 |
|
1993 |
Klippel A, Kanaar R, Kahmann R, Cozzarelli NR. Analysis of strand exchange and DNA binding of enhancer-independent Gin recombinase mutants. The Embo Journal. 12: 1047-57. PMID 8384550 DOI: 10.1002/J.1460-2075.1993.Tb05746.X |
0.451 |
|
1992 |
Kanaar R, Cozzarelli NR. Roles of supercoiled DNA structure in DNA transactions Current Opinion in Structural Biology. 2: 369-379. DOI: 10.1016/0959-440X(92)90227-X |
0.434 |
|
1990 |
Kanaar R, Klippel A, Shekhtman E, Dungan JM, Kahmann R, Cozzarelli NR. Processive recombination by the phage Mu Gin system: implications for the mechanisms of DNA strand exchange, DNA site alignment, and enhancer action. Cell. 62: 353-66. PMID 2164890 DOI: 10.1016/0092-8674(90)90372-L |
0.484 |
|
1989 |
Kanaar R, van Hal JP, van de Putte P. The recombinational enhancer for DNA inversion functions independent of its orientation as a consequence of dyad symmetry in the Fis-DNA complex. Nucleic Acids Research. 17: 6043-53. PMID 2549506 DOI: 10.1093/nar/17.15.6043 |
0.622 |
|
1989 |
Kanaar R, van de Putte P, Cozzarelli NR. Gin-mediated recombination of catenated and knotted DNA substrates: implications for the mechanism of interaction between cis-acting sites. Cell. 58: 147-59. PMID 2546671 DOI: 10.1016/0092-8674(89)90411-X |
0.623 |
|
1988 |
Kanaar R, van de Putte P, Cozzarelli NR. Gin-mediated DNA inversion: product structure and the mechanism of strand exchange. Proceedings of the National Academy of Sciences of the United States of America. 85: 752-6. PMID 2829201 DOI: 10.1073/Pnas.85.3.752 |
0.651 |
|
1987 |
Kanaar R, van de Putte P. Topological aspects of site-specific DNA-inversion. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 7: 195-200. PMID 3325048 DOI: 10.1002/Bies.950070502 |
0.631 |
|
1986 |
Kanaar R, van de Putte P, Cozzarelli NR. Purification of the Gin recombination protein of Escherichia coli phage Mu and its host factor. Biochimica Et Biophysica Acta. 866: 170-7. PMID 3006776 DOI: 10.1016/0167-4781(86)90114-4 |
0.562 |
|
1984 |
Plasterk RH, Kanaar R, van de Putte P. A genetic switch in vitro: DNA inversion by Gin protein of phage Mu. Proceedings of the National Academy of Sciences of the United States of America. 81: 2689-92. PMID 6232613 DOI: 10.1073/Pnas.81.9.2689 |
0.568 |
|
Low-probability matches (unlikely to be authored by this person) |
2014 |
Carvalho JF, Kanaar R. Targeting homologous recombination-mediated DNA repair in cancer. Expert Opinion On Therapeutic Targets. 18: 427-58. PMID 24491188 DOI: 10.1517/14728222.2014.882900 |
0.299 |
|
2001 |
Modesti M, Kanaar R. Dna repair: Spot(light)s on chromatin Current Biology. 11: R229-R232. PMID 11301269 DOI: 10.1016/S0960-9822(01)00112-9 |
0.299 |
|
2004 |
Heyer WD, Kanaar R. Recombination mechanisms; fortieth anniversary meeting of the Holliday model. Molecular Cell. 16: 1-9. PMID 15469817 DOI: 10.1016/j.molcel.2004.09.025 |
0.298 |
|
2006 |
van der Heijden T, Moreno-Herrero F, Kanaar R, Wyman C, Dekker C. Comment on "Direct and real-time visualization of the disassembly of a single RecA-DNA-ATPgammaS complex using AFM imaging in fluid". Nano Letters. 6: 3000-2. PMID 17163748 DOI: 10.1021/Nl061746J |
0.295 |
|
2020 |
Roobol SJ, van den Bent I, van Cappellen WA, Abraham TE, Paul MW, Kanaar R, Houtsmuller AB, van Gent DC, Essers J. Comparison of High- and Low-LET Radiation-Induced DNA Double-Strand Break Processing in Living Cells. International Journal of Molecular Sciences. 21. PMID 32917044 DOI: 10.3390/ijms21186602 |
0.292 |
|
2017 |
van den Tempel N, Laffeber C, Odijk H, van Cappellen WA, van Rhoon GC, Franckena M, Kanaar R. The effect of thermal dose on hyperthermia-mediated inhibition of DNA repair through homologous recombination. Oncotarget. PMID 28574821 DOI: 10.18632/oncotarget.17861 |
0.282 |
|
2019 |
Brandsma I, Sato K, van Rossum-Fikkert SE, van Vliet N, Sleddens E, Reuter M, Odijk H, van den Tempel N, Dekkers DHW, Bezstarosti K, Demmers JAA, Maas A, Lebbink J, Wyman C, Essers J, ... ... Kanaar R, et al. HSF2BP Interacts with a Conserved Domain of BRCA2 and Is Required for Mouse Spermatogenesis. Cell Reports. 27: 3790-3798.e7. PMID 31242413 DOI: 10.1016/J.Celrep.2019.05.096 |
0.282 |
|
2022 |
Meijer TG, Nguyen L, Van Hoeck A, Sieuwerts AM, Verkaik NS, Ladan MM, Ruigrok-Ritstier K, van Deurzen CHM, van de Werken HJG, Lips EH, Linn SC, Memari Y, Davies H, Nik-Zainal S, Kanaar R, et al. Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests. Oncogene. PMID 35662281 DOI: 10.1038/s41388-022-02363-1 |
0.282 |
|
2002 |
Kraakman-van der Zwet M, Overkamp WJ, van Lange RE, Essers J, van Duijn-Goedhart A, Wiggers I, Swaminathan S, van Buul PP, Errami A, Tan RT, Jaspers NG, Sharan SK, Kanaar R, Zdzienicka MZ. Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions. Molecular and Cellular Biology. 22: 669-79. PMID 11756561 DOI: 10.1128/MCB.22.2.669-679.2002 |
0.279 |
|
2006 |
Rakhorst HA, Tra WM, Posthumus-Van Sluijs ST, Hovius SE, Levendag PC, Kanaar R, Hofer SO. Quantitative analysis of radiation-induced DNA break repair in a cultured oral mucosal model. Tissue Engineering. 12: 3395-403. PMID 17518676 DOI: 10.1089/ten.2006.12.3395 |
0.279 |
|
2001 |
Modesti M, Kanaar R. Homologous recombination: From model organisms to human disease Genome Biology. 2: 1014.1-1014.5. PMID 11387040 |
0.27 |
|
2015 |
Naipal KA, Raams A, Bruens ST, Brandsma I, Verkaik NS, Jaspers NG, Hoeijmakers JH, van Leenders GJ, Pothof J, Kanaar R, Boormans J, van Gent DC. Attenuated XPC expression is not associated with impaired DNA repair in bladder cancer. Plos One. 10: e0126029. PMID 25927440 DOI: 10.1371/journal.pone.0126029 |
0.258 |
|
2013 |
Kampmann E, Harnicek D, Cardoso Martins AS, Eppink B, Gallmeier E, Lindner L, Kanaar R, Issels RD. Heat-shock (H-S) and trabectedin efficacy in human soft-tissue sarcoma (STS) cells in vitro. Journal of Clinical Oncology. 31: e13540-e13540. DOI: 10.1200/jco.2013.31.15_suppl.e13540 |
0.254 |
|
1996 |
McKay MJ, Troelstra C, Van Der Spek P, Kanaar R, Smit B, Hagemeijer A, Bootsma D, Hoeijmakers JHJ. Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double- strand break repair gene in human and mouse Genomics. 36: 305-315. PMID 8812457 DOI: 10.1006/Geno.1996.0466 |
0.253 |
|
2008 |
Stap J, Krawczyk PM, Van Oven CH, Barendsen GW, Essers J, Kanaar R, Aten JA. Induction of linear tracks of DNA double-strand breaks by alpha-particle irradiation of cells. Nature Methods. 5: 261-6. PMID 18309310 DOI: 10.1038/nmeth.f.206 |
0.253 |
|
2001 |
Loonstra A, Vooijs M, Beverloo HB, Allak BA, Van Drunen E, Kanaar R, Berns A, Jonkers J. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells Proceedings of the National Academy of Sciences of the United States of America. 98: 9209-9214. PMID 11481484 DOI: 10.1073/pnas.161269798 |
0.245 |
|
2002 |
D'Avirro N, Truong D, Luong M, Kanaar R, Selsing E. Gene conversion-like sequence transfers between transgenic antibody V genes are independent of RAD54 Journal of Immunology. 169: 3069-3075. PMID 12218123 DOI: 10.4049/Jimmunol.169.6.3069 |
0.242 |
|
2018 |
Sun J, Shi L, Kinomura A, Fukuto A, Horikoshi Y, Oma Y, Harata M, Ikura M, Ikura T, Kanaar R, Tashiro S. Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations. Elife. 7. PMID 29759113 DOI: 10.7554/eLife.32222 |
0.242 |
|
2015 |
Reuter M, Zelensky A, Smal I, Meijering E, van Cappellen WA, Martijn de Gruiter H, van Belle GJ, van Royen ME, Houtsmuller AB, Essers J, Kanaar R, Wyman C. Correction to: "BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells" [J. Cell Biol. Vol. 207 No. 5, December 8, 2014. Pages 599-613] Journal of Cell Biology. 208: 857-857. |
0.241 |
|
2004 |
Aten JA, Stap J, Krawczyk PM, van Oven CH, Hoebe RA, Essers J, Kanaar R. Dynamics of DNA double-strand breaks revealed by clustering of damaged chromosome domains. Science (New York, N.Y.). 303: 92-5. PMID 14704429 DOI: 10.1126/science.1088845 |
0.24 |
|
2015 |
Ameziane N, May P, Haitjema A, van de Vrugt HJ, van Rossum-Fikkert SE, Ristic D, Williams GJ, Balk J, Rockx D, Li H, Rooimans MA, Oostra AB, Velleuer E, Dietrich R, Bleijerveld OB, ... ... Kanaar R, et al. A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51. Nature Communications. 6: 8829. PMID 26681308 DOI: 10.1038/Ncomms9829 |
0.239 |
|
2018 |
Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker M, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips EH, Nederlof PM, Smid M, van de Werken HJG, ... Kanaar R, et al. Functional ex vivo assay reveals homologous recombination deficiency in breast cancer beyond BRCA gene defects. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 30139880 DOI: 10.1158/1078-0432.CCR-18-0063 |
0.231 |
|
2012 |
Rousseau L, Etienne O, Roque T, Desmaze C, Haton C, Mouthon MA, Bernardino-Sgherri J, Essers J, Kanaar R, Boussin FD. In vivo importance of homologous recombination DNA repair for mouse neural stem and progenitor cells. Plos One. 7: e37194. PMID 22666344 DOI: 10.1371/journal.pone.0037194 |
0.23 |
|
2004 |
McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-Sweatman O, Khokha R, Kanaar R, Jasin M, Hande MP, et al. Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science (New York, N.Y.). 304: 1822-6. PMID 15205536 DOI: 10.1126/Science.1094557 |
0.23 |
|
2021 |
Ghouil R, Miron S, Koornneef L, Veerman J, Paul MW, Le Du MH, Sleddens-Linkels E, van Rossum-Fikkert SE, van Loon Y, Felipe-Medina N, Pendas AM, Maas A, Essers J, Legrand P, Baarends WM, ... Kanaar R, et al. BRCA2 binding through a cryptic repeated motif to HSF2BP oligomers does not impact meiotic recombination. Nature Communications. 12: 4605. PMID 34326328 DOI: 10.1038/s41467-021-24871-6 |
0.229 |
|
2010 |
Sanchez H, Kanaar R, Wyman C. Molecular recognition of DNA-protein complexes: a straightforward method combining scanning force and fluorescence microscopy. Ultramicroscopy. 110: 844-51. PMID 20382478 DOI: 10.1016/J.Ultramic.2010.03.002 |
0.227 |
|
2007 |
Marchetti F, Essers J, Kanaar R, Wyrobek AJ. Disruption of maternal DNA repair increases sperm-derived chromosomal aberrations. Proceedings of the National Academy of Sciences of the United States of America. 104: 17725-9. PMID 17978187 DOI: 10.1073/pnas.0705257104 |
0.225 |
|
2011 |
Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR, Soullié T, Rens J, Verhagen HJ, O'Connor MJ, Franken NA, ... ... Kanaar R, et al. Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition. Proceedings of the National Academy of Sciences of the United States of America. 108: 9851-6. PMID 21555554 DOI: 10.1073/pnas.1101053108 |
0.225 |
|
2003 |
Bross L, Wesoly J, Buerstedde JM, Kanaar R, Jacobs H. Somatic hypermutation does not require Rad54 and Rad54B-mediated homologous recombination. European Journal of Immunology. 33: 352-7. PMID 12548566 DOI: 10.1002/immu.200310009 |
0.223 |
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2024 |
van Thiel BS, de Boer M, Ridwan Y, de Kleijnen MGJ, van Vliet N, van der Linden J, de Beer I, van Heijningen PM, Vermeij WP, Hoeijmakers JHJ, Danser AHJ, Kanaar R, Duncker DJ, van der Pluijm I, Essers J. Hybrid Molecular and Functional Micro-CT Imaging Reveals Increased Myocardial Apoptosis Preceding Cardiac Failure in Progeroid Ercc1 Mice. Molecular Imaging and Biology. PMID 38498063 DOI: 10.1007/s11307-024-01902-4 |
0.22 |
|
1993 |
Kanaar R, Roche SE, Beall EL, Green MR, Rio DC. The conserved pre-mRNA splicing factor U2AF from Drosophila: requirement for viability. Science (New York, N.Y.). 262: 569-73. PMID 7692602 |
0.22 |
|
2016 |
Van Gent D, Naipal K, Verkaik N, Meijer T, Hoeijmakers J, Van Deurzen C, Kanaar R, Jager A. DNA damage responses and chemosensitivity of breast cancer tissue slices ex vivo European Journal of Cancer. 61: S21. DOI: 10.1016/S0959-8049(16)61062-6 |
0.22 |
|
2016 |
Oei AL, Vriend LE, van Leeuwen CM, Rodermond HM, Ten Cate R, Westermann AM, Stalpers LJ, Crezee J, Kanaar R, Kok HP, Krawczyk PM, Franken NA. Sensitizing thermochemotherapy with a PARP1-inhibitor. Oncotarget. PMID 27557507 DOI: 10.18632/oncotarget.11422 |
0.219 |
|
2016 |
Chen S, Zambetti NA, Ping Z, Kenswil K, Mylona M, Sanders MA, Hoogenboezem R, Bindels E, Adisty M, van Strien PMH, van der Leije C, Westers TM, Cremers EM, Milanese C, Mastroberardino P, ... ... Kanaar R, et al. Inflammatory Niche Signalling Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Leukemic Evolution in Human Leukemia Predisposition Syndromes Blood. 128: 428-428. DOI: 10.1182/Blood.V128.22.428.428 |
0.215 |
|
2023 |
Gaggioli V, Lo CSY, Reverón-Gómez N, Jasencakova Z, Domenech H, Nguyen H, Sidoli S, Tvardovskiy A, Uruci S, Slotman JA, Chai Y, Gonçalves JGSCS, Manolika EM, Jensen ON, Wheeler D, ... ... Kanaar R, et al. Dynamic de novo heterochromatin assembly and disassembly at replication forks ensures fork stability. Nature Cell Biology. PMID 37414849 DOI: 10.1038/s41556-023-01167-z |
0.215 |
|
2022 |
Su PR, You L, Beerens C, Bezstarosti K, Demmers J, Pabst M, Kanaar R, Hsu CC, Chien MP. Microscopy-based single-cell proteomic profiling reveals heterogeneity in DNA damage response dynamics. Cell Reports Methods. 2: 100237. PMID 35784653 DOI: 10.1016/j.crmeth.2022.100237 |
0.214 |
|
2022 |
Meijer TG, Verkaik NS, van Deurzen CHM, Dubbink HJ, den Toom TD, Sleddens HFBM, De Hoop EO, Dinjens WNM, Kanaar R, van Gent DC, Jager A. Direct Ex Vivo Observation of Homologous Recombination Defect Reversal After DNA-Damaging Chemotherapy in Patients With Metastatic Breast Cancer. Jco Precision Oncology. 3: 1-12. PMID 35100677 DOI: 10.1200/PO.18.00268 |
0.214 |
|
2008 |
Kanaar R, Wyman C. DNA repair by the MRN complex: break it to make it. Cell. 135: 14-6. PMID 18854148 DOI: 10.1016/J.Cell.2008.09.027 |
0.214 |
|
1996 |
Rudner DZ, Kanaar R, Breger KS, Rio DC. Mutations in the small subunit of the Drosophila U2AF splicing factor cause lethality and developmental defects. Proceedings of the National Academy of Sciences of the United States of America. 93: 10333-7. PMID 8816800 DOI: 10.1073/Pnas.93.19.10333 |
0.211 |
|
1999 |
Parisi S, McKay MJ, Molnar M, Thompson MA, van der Spek PJ, van Drunen-Schoenmaker E, Kanaar R, Lehmann E, Hoeijmakers JH, Kohli J. Rec8p, a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. Molecular and Cellular Biology. 19: 3515-28. PMID 10207075 DOI: 10.1128/Mcb.19.5.3515 |
0.211 |
|
1994 |
Siebel CW, Kanaar R, Rio DC. Regulation of tissue-specific P-element pre-mRNA splicing requires the RNA-binding protein PSI. Genes & Development. 8: 1713-25. PMID 7958851 DOI: 10.1101/Gad.8.14.1713 |
0.206 |
|
2007 |
Agarwal S, Kanaar R, Essers J. The cell biology of homologous recombination Topics in Current Genetics. 17: 381-442. DOI: 10.1007/4735_2006_0214 |
0.204 |
|
2016 |
van den Tempel N, Horsman MR, Kanaar R. Improving efficacy of hyperthermia in oncology by exploiting biological mechanisms. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 1-9. PMID 27086587 DOI: 10.3109/02656736.2016.1157216 |
0.203 |
|
2015 |
Pont LM, Naipal K, Kloezeman JJ, Venkatesan S, van den Bent M, van Gent DC, Dirven CM, Kanaar R, Lamfers ML, Leenstra S. DNA damage response and anti-apoptotic proteins predict radiosensitization efficacy of HDAC inhibitors SAHA and LBH589 in patient-derived glioblastoma cells. Cancer Letters. 356: 525-35. PMID 25305451 DOI: 10.1016/j.canlet.2014.09.049 |
0.202 |
|
2017 |
van den Tempel N, Odijk H, van Holthe N, Naipal K, Raams A, Eppink B, van Gent D, Hardillo J, Verduijn G, Drooger J, van Rhoon G, Smedts D, van Doorn H, Boormans J, Jager A, ... ... Kanaar R, et al. Heat-induced BRCA2 degradation in human tumors provides rationale for hyperthermia-PARP-inhibitor combination therapies. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 1-31. PMID 28705099 DOI: 10.1080/02656736.2017.1355487 |
0.198 |
|
2005 |
Essers J, van Cappellen WA, Theil AF, van Drunen E, Jaspers NG, Hoeijmakers JH, Wyman C, Vermeulen W, Kanaar R. Dynamics of relative chromosome position during the cell cycle. Molecular Biology of the Cell. 16: 769-75. PMID 15574874 DOI: 10.1091/Mbc.E04-10-0876 |
0.187 |
|
2017 |
Vriend LEM, van den Tempel N, Oei AL, L'Acosta M, Pieterson FJ, Franken NAP, Kanaar R, Krawczyk PM. Boosting the effects of hyperthermia-based anticancer treatments by HSP90 inhibition. Oncotarget. 8: 97490-97503. PMID 29228626 DOI: 10.18632/oncotarget.22142 |
0.18 |
|
2013 |
Messiaen S, Le Bras A, Duquenne C, Barroca V, Moison D, Déchamps N, Doussau M, Bauchet AL, Guerquin MJ, Livera G, Essers J, Kanaar R, Habert R, Bernardino-Sgherri J. Rad54 is required for the normal development of male and female germ cells and contributes to the maintainance of their genome integrity after genotoxic stress. Cell Death & Disease. 4: e774. PMID 23949223 DOI: 10.1038/cddis.2013.281 |
0.177 |
|
2020 |
Roobol SJ, Hartjes TA, Slotman JA, de Kruijff RM, Torrelo G, Abraham TE, Bruchertseifer F, Morgenstern A, Kanaar R, van Gent DC, Houtsmuller AB, Denkova AG, van Royen ME, Essers J. Uptake and subcellular distribution of radiolabeled polymersomes for radiotherapy. Nanotheranostics. 4: 14-25. PMID 31911891 DOI: 10.7150/ntno.37080 |
0.175 |
|
1995 |
Kanaar R, Lee AL, Rudner DZ, Wemmer DE, Rio DC. Interaction of the sex-lethal RNA binding domains with RNA. The Embo Journal. 14: 4530-9. PMID 7556096 DOI: 10.1002/J.1460-2075.1995.Tb00132.X |
0.159 |
|
2022 |
Scutigliani EM, Liang Y, IJff M, Rodermond H, Mei X, Korver MP, Orie VS, Hoebe RA, Picavet DI, Oei A, Kanaar R, Krawczyk PM. Evaluation of the Heat Shock Protein 90 Inhibitor Ganetespib as a Sensitizer to Hyperthermia-Based Cancer Treatments. Cancers. 14. PMID 36358669 DOI: 10.3390/cancers14215250 |
0.158 |
|
2018 |
van den Tempel N, Naipal KAT, Raams A, van Gent DC, Franckena M, Boormans JL, Kanaar R. Ex vivo assays to predict enhanced chemosensitization by hyperthermia in urothelial cancer of the bladder. Plos One. 13: e0209101. PMID 30550547 DOI: 10.1371/journal.pone.0209101 |
0.155 |
|
1998 |
Rudner DZ, Breger KS, Kanaar R, Adams MD, Rio DC. RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Molecular and Cellular Biology. 18: 4004-11. PMID 9632785 DOI: 10.1128/Mcb.18.7.4004 |
0.152 |
|
1997 |
Hammond LE, Rudner DZ, Kanaar R, Rio DC. Mutations in the hrp48 gene, which encodes a Drosophila heterogeneous nuclear ribonucleoprotein particle protein, cause lethality and developmental defects and affect P-element third-intron splicing in vivo. Molecular and Cellular Biology. 17: 7260-7. PMID 9372958 DOI: 10.1128/Mcb.17.12.7260 |
0.152 |
|
1998 |
Rudner DZ, Kanaar R, Breger KS, Rio DC. Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo. Molecular and Cellular Biology. 18: 1765-73. PMID 9528748 DOI: 10.1128/Mcb.18.4.1765 |
0.15 |
|
2021 |
Laffeber C, de Koning K, Kanaar R, Lebbink JHG. Experimental Evidence for Enhanced Receptor Binding by Rapidly Spreading SARS-CoV-2 Variants. Journal of Molecular Biology. 433: 167058. PMID 34023401 DOI: 10.1016/j.jmb.2021.167058 |
0.142 |
|
1997 |
Lee AL, Volkman BF, Robertson SA, Rudner DZ, Barbash DA, Cline TW, Kanaar R, Rio DC, Wemmer DE. Chemical shift mapping of the RNA-binding interface of the multiple-RBD protein sex-lethal. Biochemistry. 36: 14306-17. PMID 9398148 DOI: 10.1021/Bi970830Y |
0.139 |
|
1999 |
Crowder SM, Kanaar R, Rio DC, Alber T. Absence of interdomain contacts in the crystal structure of the RNA recognition motifs of Sex-lethal. Proceedings of the National Academy of Sciences of the United States of America. 96: 4892-7. PMID 10220389 DOI: 10.1073/Pnas.96.9.4892 |
0.137 |
|
2019 |
Burger J, van Vliet N, van Heijningen P, Kumra H, Kremers GJ, Alves M, van Cappellen G, Yanagisawa H, Reinhardt DP, Kanaar R, van der Pluijm I, Essers J. Fibulin-4 deficiency differentially affects cytoskeleton structure and dynamics as well as TGFβ signaling. Cellular Signalling. PMID 30844428 DOI: 10.1016/J.Cellsig.2019.02.008 |
0.137 |
|
2011 |
Wyman C, Lebbink J, Kanaar R. Mre11-Rad50 complex crystals suggest molecular calisthenics. Dna Repair. 10: 1066-70. PMID 21893433 DOI: 10.1016/J.Dnarep.2011.07.008 |
0.132 |
|
2002 |
Wyman C, Kanaar R. Chromosome organization: Reaching out to embrace new models Current Biology. 12: R446-R448. PMID 12121633 DOI: 10.1016/S0960-9822(02)00941-7 |
0.126 |
|
2017 |
Kuzniar A, Laffeber C, Eppink B, Bezstarosti K, Dekkers D, Woelders H, Zwamborn AP, Demmers J, Lebbink JH, Kanaar R. Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields. Plos One. 12: e0170762. PMID 28234898 DOI: 10.1371/journal.pone.0170762 |
0.124 |
|
1994 |
Lee AL, Kanaar R, Rio DC, Wemmer DE. Resonance assignments and solution structure of the second RNA-binding domain of sex-lethal determined by multidimensional heteronuclear magnetic resonance. Biochemistry. 33: 13775-86. PMID 7524663 DOI: 10.1021/Bi00250A031 |
0.122 |
|
2018 |
Wu WY, Lebbink JHG, Kanaar R, Geijsen N, van der Oost J. Genome editing by natural and engineered CRISPR-associated nucleases. Nature Chemical Biology. 14: 642-651. PMID 29915237 DOI: 10.1038/s41589-018-0080-x |
0.12 |
|
2024 |
de Wagenaar NP, van den Bersselaar LM, Odijk HJHM, Stefens SJM, Reinhardt DP, Roos-Hesselink JW, Kanaar R, Verhagen JMA, Brüggenwirth HT, van de Laar IMBH, van der Pluijm I, Essers J. Functional analysis of cell lines derived from SMAD3-related Loeys-Dietz syndrome patients provides insights into genotype-phenotype relation. Human Molecular Genetics. PMID 38538566 DOI: 10.1093/hmg/ddae044 |
0.12 |
|
2024 |
Meijer TG, Martens JWM, Prager-van der Smissen WJC, Verkaik NS, Beaufort CM, van Herk S, Robert-Finestra T, Hoogenboezem RM, Ruigrok-Ritstier K, Paul MW, Gribnau J, Bindels EMJ, Kanaar R, Jager A, van Gent DC, et al. Functional Homologous Recombination (HR) Screening Shows the Majority of -Mutant Breast and Ovarian Cancer Cell Lines Are HR-Proficient. Cancers. 16. PMID 38398132 DOI: 10.3390/cancers16040741 |
0.118 |
|
2014 |
Kuzniar A, Kanaar R. PIQMIe: a web server for semi-quantitative proteomics data management and analysis. Nucleic Acids Research. 42: W100-6. PMID 24861615 DOI: 10.1093/nar/gku478 |
0.113 |
|
2019 |
Meijer TG, Verkaik NS, Sieuwerts AM, van Riet J, Naipal KAT, van Deurzen CHM, den Bakker MA, Sleddens HFBM, Dubbink HJ, den Toom TD, Dinjens WNM, Lips E, Nederlof PM, Smid M, van de Werken HJG, ... Kanaar R, et al. Correction: Functional Assay Reveals Homologous Recombination Deficiency in Breast Cancer Beyond BRCA Gene Defects. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 25: 2935. PMID 31043383 DOI: 10.1158/1078-0432.CCR-19-0936 |
0.112 |
|
2016 |
Issels R, Kampmann E, Kanaar R, Lindner LH. Hallmarks of hyperthermia in driving the future of clinical hyperthermia as targeted therapy: translation into clinical application. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 1-7. PMID 26803991 DOI: 10.3109/02656736.2015.1119317 |
0.112 |
|
2007 |
Hanada K, Vermeij M, Garinis GA, de Waard MC, Kunen MG, Myers L, Maas A, Duncker DJ, Meijers C, Dietz HC, Kanaar R, Essers J. Perturbations of vascular homeostasis and aortic valve abnormalities in fibulin-4 deficient mice. Circulation Research. 100: 738-46. PMID 17293478 DOI: 10.1161/01.Res.0000260181.19449.95 |
0.109 |
|
2016 |
Zambetti NA, Ping Z, Chen S, Kenswil KJ, Mylona MA, Sanders MA, Hoogenboezem RM, Bindels EM, Adisty MN, Van Strien PM, van der Leije CS, Westers TM, Cremers EM, Milanese C, Mastroberardino PG, ... ... Kanaar R, et al. Mesenchymal Inflammation Drives Genotoxic Stress in Hematopoietic Stem Cells and Predicts Disease Evolution in Human Pre-leukemia. Cell Stem Cell. PMID 27666011 DOI: 10.1016/J.Stem.2016.08.021 |
0.105 |
|
2014 |
Naipal KA, Verkaik NS, Ameziane N, van Deurzen CH, Ter Brugge P, Meijers M, Sieuwerts AM, Martens JW, O'Connor MJ, Vrieling H, Hoeijmakers JH, Jonkers J, Kanaar R, de Winter JP, Vreeswijk MP, et al. Functional ex vivo assay to select homologous recombination-deficient breast tumors for PARP inhibitor treatment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 4816-26. PMID 24963051 DOI: 10.1158/1078-0432.CCR-14-0571 |
0.095 |
|
2019 |
Roobol SJ, Kouwenberg JJM, Denkova AG, Kanaar R, Essers J. Large Field Alpha Irradiation Setup for Radiobiological Experiments. Methods and Protocols. 2. PMID 31466405 DOI: 10.3390/mps2030075 |
0.083 |
|
2016 |
van der Pluijm I, van Vliet N, von der Thusen JH, Robertus JL, Ridwan Y, van Heijningen PM, van Thiel BS, Vermeij M, Hoeks SE, Buijs-Offerman RMGB, Verhagen HJM, Kanaar R, Bertoli-Avella AM, Essers J. Defective Connective Tissue Remodeling in Smad3 Mice Leads to Accelerated Aneurysmal Growth Through Disturbed Downstream TGF-β Signaling. Ebiomedicine. 12: 280-294. PMID 27688095 DOI: 10.1016/j.ebiom.2016.09.006 |
0.074 |
|
2023 |
Ladan MM, Meijer TG, Verkaik NS, de Monye C, Koppert LB, Oomen-de Hoop E, van Deurzen CHM, Kanaar R, Nonnekens J, van Gent DC, Jager A. Proof-of-concept study linking ex vivo sensitivity testing to neoadjuvant anthracycline-based chemotherapy response in breast cancer patients. Npj Breast Cancer. 9: 80. PMID 37777518 DOI: 10.1038/s41523-023-00583-6 |
0.071 |
|
2021 |
Scutigliani EM, Liang Y, Crezee H, Kanaar R, Krawczyk PM. Modulating the Heat Stress Response to Improve Hyperthermia-Based Anticancer Treatments. Cancers. 13. PMID 33808973 DOI: 10.3390/cancers13061243 |
0.066 |
|
2022 |
Ladan MM, Meijer TG, Verkaik NS, Komar ZM, van Deurzen CHM, den Bakker MA, Kanaar R, van Gent DC, Jager A. Functional Ex Vivo Tissue-Based Chemotherapy Sensitivity Testing for Breast Cancer. Cancers. 14. PMID 35267560 DOI: 10.3390/cancers14051252 |
0.06 |
|
2014 |
Ramnath NW, van de Luijtgaarden KM, van der Pluijm I, van Nimwegen M, van Heijningen PM, Swagemakers SM, van Thiel BS, Ridwan RY, van Vliet N, Vermeij M, Hawinkels LJ, de Munck A, Dzyubachyk O, Meijering E, van der Spek P, ... ... Kanaar R, et al. Extracellular matrix defects in aneurysmal Fibulin-4 mice predispose to lung emphysema. Plos One. 9: e106054. PMID 25255451 DOI: 10.1371/journal.pone.0106054 |
0.058 |
|
2015 |
Naipal KA, Verkaik NS, Sánchez H, van Deurzen CH, den Bakker MA, Hoeijmakers JH, Kanaar R, Vreeswijk MP, Jager A, van Gent DC. Tumor slice culture system to assess drug response of primary breast cancer. Bmc Cancer. 16: 78. PMID 26860465 DOI: 10.1186/s12885-016-2119-2 |
0.058 |
|
2006 |
Aten JA, Kanaar R. Chromosomal organization: mingling with the neighbors. Plos Biology. 4: e155. PMID 16683864 DOI: 10.1371/journal.pbio.0040155 |
0.056 |
|
2002 |
De Jager M, Kanaar R. Genome instability and Rad50 S: Subtle yet severe Genes and Development. 16: 2173-2178. PMID 12208840 DOI: 10.1101/gad.1025402 |
0.052 |
|
2021 |
Chakrabarty S, Quiros-Solano WF, Kuijten MM, Haspels B, Mallya S, Lo CSY, Othman A, Silvestri C, van de Stolpe A, Gaio N, Odijk H, van de Ven M, M A de Ridder C, van Weerden WM, Jonkers J, ... ... Kanaar R, et al. A microfluidic cancer-on-chip platform predicts drug response using organotypic tumor slice culture. Cancer Research. PMID 34872965 DOI: 10.1158/0008-5472.CAN-21-0799 |
0.051 |
|
2015 |
Braks JA, Spiegelberg L, Koljenovic S, Ridwan Y, Keereweer S, Kanaar R, Wolvius EB, Essers J. Optical Imaging of Tumor Response to Hyperbaric Oxygen Treatment and Irradiation in an Orthotopic Mouse Model of Head and Neck Squamous Cell Carcinoma. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 25724406 DOI: 10.1007/s11307-015-0834-8 |
0.045 |
|
2015 |
Ramnath NW, Hawinkels LJ, van Heijningen PM, Riet LT, Paauwe M, Vermeij M, Danser AH, Kanaar R, Ten Dijke P, Essers J. Fibulin-4 deficiency increases TGF-β signalling in aortic smooth muscle cells due to elevated TGF-β2 levels. Scientific Reports. 5: 16872. PMID 26607280 DOI: 10.1038/srep16872 |
0.043 |
|
2006 |
Kanaar R, Sherratt D. Nicholas (Nick) R. Cozzarelli 1938–2006 Cell. 125: 415-417. DOI: 10.1016/j.cell.2006.04.020 |
0.03 |
|
2018 |
Zhang W, van Weerden WM, de Ridder CMA, Erkens-Schulze S, Schönfeld E, Meijer TG, Kanaar R, van Gent DC, Nonnekens J. Ex vivo treatment of prostate tumor tissue recapitulates in vivo therapy response. The Prostate. PMID 30520109 DOI: 10.1002/pros.23745 |
0.029 |
|
2007 |
Tra W, Rakhorst H, Posthumus-van Sluijs S, Hovius S, Kanaar R, Hofer S. Effects of radiation on cultured mucosal substitues Journal of Plastic, Reconstructive & Aesthetic Surgery. 60: S15. DOI: 10.1016/j.bjps.2007.01.058 |
0.029 |
|
2011 |
Morak MJ, van Koetsveld PM, Kanaar R, Hofland LJ, van Eijck CH. Type I interferons as radiosensitisers for pancreatic cancer. European Journal of Cancer (Oxford, England : 1990). 47: 1938-45. PMID 21478011 DOI: 10.1016/j.ejca.2011.03.009 |
0.027 |
|
2013 |
Aaberg-Jessen C, Fogh L, Halle B, Jensen V, Brunner N, Kristensen BW, Abe T, Momii Y, Watanabe J, Morisaki I, Natsume A, Wakabayashi T, Fujiki M, Aldaz B, Fabius AWM, ... ... Kanaar R, et al. EXPERIMENTAL THERAPEUTICS AND PHARMACOLOGY Neuro-Oncology. 15: iii37-iii61. DOI: 10.1093/Neuonc/Not176 |
0.027 |
|
1998 |
Kanaar R, Hoeljmakers JHJ. From competition to collaboration Nature. 391: 335-338. PMID 9450742 DOI: 10.1038/34790 |
0.024 |
|
2008 |
Tra W, Rakhorst H, Hofer S, Kanaar R, Perez-Amodio S. Effects of radiation on tissue-engineered mucosa 8th World Biomaterials Congress 2008. 2: 1078. |
0.02 |
|
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