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George R. Pettit - Publications

Affiliations: 
1956-1965 The University of Maine, Orono, MN, United States 
 1965- Chemistry Arizona State University, Tempe, AZ, United States 
Area:
Organic Chemistry
Website:
https://sms.asu.edu/george_pettit

270 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pettit GR, Melody N, Chapuis JC. Antineoplastic Agents. 607. Emetine Auristatins. Journal of Natural Products. PMID 32323990 DOI: 10.1021/Acs.Jnatprod.0C00031  0.36
2018 Pettit GR, Melody N, Chapuis JC. Antineoplastic Agents. 606. The Betulastatins. Journal of Natural Products. PMID 29303263 DOI: 10.1021/Acs.Jnatprod.7B00536  0.36
2017 Pettit GR, Melody N, Chapuis JC. Antineoplastic Agents. 605. Isoquinstatins. Journal of Natural Products. PMID 28926240 DOI: 10.1021/Acs.Jnatprod.7B00352  0.36
2017 Pettit GR, Melody N, Chapuis JC. Antineoplastic Agents. 604. The Path of Quinstatin Derivatives to Antibody Drug Conjugates. Journal of Natural Products. PMID 28895394 DOI: 10.1021/Acs.Jnatprod.7B00237  0.36
2017 Pettit GR, Melody N, Chapuis JC. Antineoplastic Agents. 603. Quinstatins: Exceptional Cancer Cell Growth Inhibitors. Journal of Natural Products. PMID 28211277 DOI: 10.1021/Acs.Jnatprod.6B01006  0.36
2016 Pettit GR, Ye Q, Herald DL, Knight JC, Hogan F, Melody N, Mukku VJ, Doubek DL, Chapuis JC. Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae. Journal of Natural Products. PMID 27214528 DOI: 10.1021/Acs.Jnatprod.6B00107  1
2016 Pettit GR, Searcy JD, Tan R, Cragg GM, Melody N, Knight JC, Chapuis JC. Antineoplastic Agents. 585. Isolation of Bridelia ferruginea Anticancer Podophyllotoxins and Synthesis of 4-Aza-podophyllotoxin Structural Modifications1. Journal of Natural Products. PMID 26938998 DOI: 10.1021/Acs.Jnatprod.5B00873  1
2015 Pettit GR, Xu JP, Chapuis JC, Melody N. The Cephalostatins. 24. Isolation, Structure, and Cancer Cell Growth Inhibition of Cephalostatin 20. Journal of Natural Products. 78: 1446-50. PMID 26042639 DOI: 10.1021/Acs.Jnatprod.5B00129  1
2015 Pettit GR, Moser BR, Herald DL, Knight JC, Chapuis JC, Zheng X. The Cephalostatins. 23. Conversion of Hecogenin to a Steroidal 1,6-Dioxaspiro[5.5]nonane Analogue for Cephalostatin 11. Journal of Natural Products. 78: 1067-72. PMID 25915559 DOI: 10.1021/Np501033U  1
2015 Kedei N, Kraft MB, Keck GE, Herald CL, Melody N, Pettit GR, Blumberg PM. Neristatin 1 provides critical insight into bryostatin 1 structure-function relationships. Journal of Natural Products. 78: 896-900. PMID 25808573 DOI: 10.1021/Acs.Jnatprod.5B00094  1
2015 Pettit GR, Smith TH, Arce PM, Flahive EJ, Anderson CR, Chapuis JC, Xu JP, Groy TL, Belcher PE, Macdonald CB. Antineoplastic agents. 599. Total synthesis of dolastatin 16. Journal of Natural Products. 78: 476-85. PMID 25689568 DOI: 10.1021/Np500925Y  1
2015 Pettit GR, Arce PM, Chapuis JC, Macdonald CB. Antineoplastic agents. 600. From the South Pacific Ocean to the silstatins. Journal of Natural Products. 78: 510-23. PMID 25688575 DOI: 10.1021/Np501004H  1
2015 Pettit GR, Tan R, Pettit RK, Doubek DL, Chapuis JC, Weber CA. Antineoplastic agents 596. Isolation and structure of chromomycin A5 from a Beaufort Sea microorganism Rsc Advances. 5: 9116-9122. DOI: 10.1039/C4Ra16517A  1
2014 Pettit GR, Melody N, Hempenstall F, Chapuis JC, Groy TL, Williams L. Antineoplastic agents. 595. Structural modifications of betulin and the X-ray crystal structure of an unusual betulin amine dimer. Journal of Natural Products. 77: 863-72. PMID 24694263 DOI: 10.1021/Np400947D  1
2013 Hadimani MB, Macdonough MT, Ghatak A, Strecker TE, Lopez R, Sriram M, Nguyen BL, Hall JJ, Kessler RJ, Shirali AR, Liu L, Garner CM, Pettit GR, Hamel E, Chaplin DJ, et al. Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent. Journal of Natural Products. 76: 1668-78. PMID 24016002 DOI: 10.1021/Np400374W  1
2013 Pettit GR, Tang Y, Zhang Q, Bourne GT, Arm CA, Leet JE, Knight JC, Pettit RK, Chapuis JC, Doubek DL, Ward FJ, Weber C, Hooper JN. Isolation and structures of axistatins 1-3 from the Republic of Palau marine sponge Agelas axifera Hentschel . Journal of Natural Products. 76: 420-4. PMID 23410078 DOI: 10.1021/Np300828Y  1
2012 Pettit GR, Moser BR, Mendonça RF, Knight JC, Hogan F. The cephalostatins. 22. synthesis of bis-steroidal pyrazine pyrones (1). Journal of Natural Products. 75: 1063-9. PMID 22607450 DOI: 10.1021/Np300069Z  1
2012 Pettit GR, Tan R, Bao GH, Melody N, Doubek DL, Gao S, Chapuis JC, Williams L. Antineoplastic agents. 587. Isolation and structure of 3-epipancratistatin from Narcissus cv. Ice Follies. Journal of Natural Products. 75: 771-3. PMID 22413911 DOI: 10.1021/Np200862Y  1
2012 Pettit GR, Rosenberg HJ, Dixon R, Knight JC, Hamel E, Chapuis JC, Pettit RK, Hogan F, Sumner B, Ain KB, Trickey-Platt B. Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs. Journal of Natural Products. 75: 385-93. PMID 22324723 DOI: 10.1021/Np200797X  1
2012 Lubahn C, Schaller JA, Shewmacker E, Wood C, Bellinger DL, Byron D, Melody N, Pettit GR, Lorton D. Preclinical efficacy of sodium narcistatin to reduce inflammation and joint destruction in rats with adjuvant-induced arthritis. Rheumatology International. 32: 3751-60. PMID 22159913 DOI: 10.1007/S00296-011-2217-Z  1
2011 Pettit GR, Mendonça RF, Knight JC, Pettit RK. The cephalostatins. 21. Synthesis of bis-steroidal pyrazine rhamnosides (1). Journal of Natural Products. 74: 1922-30. PMID 21899266 DOI: 10.1021/Np200411P  1
2011 Tanpure RP, Nguyen BL, Strecker TE, Aguirre S, Sharma S, Chaplin DJ, Siim BG, Hamel E, Lippert JW, Pettit GR, Trawick ML, Pinney KG. Regioselective synthesis of water-soluble monophosphate derivatives of combretastatin A-1. Journal of Natural Products. 74: 1568-74. PMID 21718055 DOI: 10.1021/Np200104T  1
2011 Bai R, Nguyen TL, Burnett JC, Atasoylu O, Munro MH, Pettit GR, Smith AB, Gussio R, Hamel E. Interactions of halichondrin B and eribulin with tubulin. Journal of Chemical Information and Modeling. 51: 1393-404. PMID 21539396 DOI: 10.1021/Ci200077T  1
2011 Pettit GR, Smith TH, Xu JP, Herald DL, Flahive EJ, Anderson CR, Belcher PE, Knight JC. Antineoplastic agents. 590. X-ray crystal structure of dolastatin 16 and syntheses of the dolamethylleuine and dolaphenvaline units. Journal of Natural Products. 74: 1003-8. PMID 21539315 DOI: 10.1021/Np100877H  1
2011 Pettit GR, Hogan F, Toms S. Antineoplastic agents. 592. Highly effective cancer cell growth inhibitory structural modifications of dolastatin 10. Journal of Natural Products. 74: 962-8. PMID 21534541 DOI: 10.1021/Np1007334  1
2011 Abi-Ghanem D, Lai X, Berghman LR, Horvat D, Li J, Romo D, Uddin MN, Kamano Y, Nogawa T, Xu JP, Pettit GR, Puschett JB. A chemifluorescent immunoassay for the determination of marinobufagenin in body fluids. Journal of Immunoassay & Immunochemistry. 32: 31-46. PMID 21253968 DOI: 10.1080/15321819.2010.538107  1
2010 Prokopiou EM, Cooper PA, Pettit GR, Bibby MC, Shnyder SD. Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10. Molecular Medicine Reports. 3: 309-13. PMID 21472238 DOI: 10.3892/Mmr_00000256  1
2010 Pettit GR, Meng Y, Pettit RK, Herald DL, Hogan F, Cichacz ZA. Antineoplastic agents 582. Part 1: Isolation and structure of a cyclobutane-type sesquiterpene cancer cell growth inhibitor from Coprinus cinereus (Coprinaceae). Bioorganic & Medicinal Chemistry. 18: 4879-83. PMID 20598551 DOI: 10.1016/J.Bmc.2010.06.023  1
2010 Pettit GR, Ye Q, Herald DL, Hogan F, Pettit RK. Antineoplastic agents. 573. isolation and structure of papilistatin from the papilionid butterfly Byasa polyeuctes termessa. Journal of Natural Products. 73: 164-6. PMID 20085286 DOI: 10.1021/Np9004689  1
2010 Pettit GR, Minardi MD, Hogan F, Price PM. An efficient synthetic strategy for obtaining 4-methoxy carbon isotope labeled combretastatin A-4 phosphate and other Z-combretastatins. Journal of Natural Products. 73: 399-403. PMID 20028026 DOI: 10.1021/Np9004486  1
2010 Pettit RK, Pettit GR, Xu JP, Weber CA, Richert LA. Isolation of human cancer cell growth inhibitory, antimicrobial lateritin from a mixed fungal culture. Planta Medica. 76: 500-1. PMID 19941263 DOI: 10.1055/S-0029-1240617  1
2010 Pettit GR, Meng Y, Pettit RK, Herald DL, Cichacz ZA, Doubek DL, Richert L. Antineoplastic agents. 556. Isolation and structure of Coprinastatin 1 from Coprinus cinereus. Journal of Natural Products. 73: 388-92. PMID 19919060 DOI: 10.1021/Np900371J  1
2010 Zheng X, Du J, Xu Y, Liao D, Pettit GR. Cytotoxic lipid esters from Peucedanum ledebourielloides Medicinal Chemistry Research. 19: 337-343. DOI: 10.1007/S00044-009-9193-9  1
2009 Pettit GR, Quistorf PD, Fry JA, Herald DL, Hamel E, Chapuis JC. Antineoplastic agents. 565. Synthesis of combretastatin D-2 phosphate and dihydro-combretastatin D-2. Journal of Natural Products. 72: 876-83. PMID 20161135 DOI: 10.1021/Np800635H  1
2009 Pettit RK, Weber CA, Pettit GR. Application of a high throughput Alamar blue biofilm susceptibility assay to Staphylococcus aureus biofilms. Annals of Clinical Microbiology and Antimicrobials. 8: 28. PMID 19860905 DOI: 10.1186/1476-0711-8-28  1
2009 Pettit GR, Melody N, Thornhill A, Knight JC, Groy TL, Herald CL. Antineoplastic agents. 579. Synthesis and cancer cell growth evaluation of E-stilstatin 3: a resveratrol structural modification. Journal of Natural Products. 72: 1637-42. PMID 19719153 DOI: 10.1021/Np9002146  1
2009 Pettit RK, Pettit GR, Hamel E, Hogan F, Moser BR, Wolf S, Pon S, Chapuis JC, Schmidt JM. E-Combretastatin and E-resveratrol structural modifications: antimicrobial and cancer cell growth inhibitory beta-E-nitrostyrenes. Bioorganic & Medicinal Chemistry. 17: 6606-12. PMID 19709889 DOI: 10.1016/J.Bmc.2009.07.076  1
2009 Pettit RK, Weber CA, Lawrence SB, Pettit GR, Kean MJ, Cage GD. In vivo activity of anprocide alone, and in vitro activity in combination with conventional antibiotics against Staphylococcus aureus and Staphylococcus epidermidis biofilms. Journal of Medical Microbiology. 58: 1203-6. PMID 19528175 DOI: 10.1099/Jmm.0.008268-0  1
2009 Pettit GR, Ducki S, Eastham SA, Melody N. Antineoplastic agents. 454. Synthesis of the strong cancer cell growth inhibitors trans-dihydronarciclasine and 7-deoxy-trans-dihydronarciclasine (1a). Journal of Natural Products. 72: 1279-82. PMID 19522518 DOI: 10.1021/Np9001948  1
2009 Pettit GR, Thornhill A, Melody N, Knight JC. Antineoplastic agents. 578. Synthesis of stilstatins 1 and 2 and their water-soluble prodrugs. Journal of Natural Products. 72: 380-8. PMID 19228038 DOI: 10.1021/Np800608C  1
2009 Pettit GR, Knight JC, Herald DL, Pettit RK, Hogan F, Mukku VJ, Hamblin JS, Dodson MJ, Chapuis JC. Antineoplastic agents. 570. Isolation and structure elucidation of bacillistatins 1 and 2 from a marine Bacillus silvestris. Journal of Natural Products. 72: 366-71. PMID 19226154 DOI: 10.1021/Np800603U  1
2009 Pettit GR, Hu S, Knight JC, Chapuis JC. Antineoplastic agents. 571. Total synthesis of bacillistatin 2. Journal of Natural Products. 72: 372-9. PMID 19216517 DOI: 10.1021/Np800607X  1
2009 Bai R, Edler MC, Bonate PL, Copeland TD, Pettit GR, Ludueña RF, Hamel E. Intracellular activation and deactivation of tasidotin, an analog of dolastatin 15: correlation with cytotoxicity. Molecular Pharmacology. 75: 218-26. PMID 18927208 DOI: 10.1124/Mol.108.051110  1
2009 Pettit GR, Du J, Pettit RK, Knight JC, Doubek DL. Antineoplastic agents. 575. The fungus Aspergillus phoenicis Heterocycles. 79: 909-916. DOI: 10.3987/Com-08-S(D)63  1
2009 Padmaja L, Ravikumar C, Sajan D, Joe IH, Jayakumar VS, Pettit GR, Nielsen OF. Density functional study on the structural conformations and intramolecular charge transfer from the vibrational spectra of the anticancer drug combretastatin-A2 Journal of Raman Spectroscopy. 40: 419-428. DOI: 10.1002/Jrs.2145  1
2008 Rudy A, López-Antón N, Barth N, Pettit GR, Dirsch VM, Schulze-Osthoff K, Rehm M, Prehn JHM, Vogler M, Fulda S, Vollmar AM. Role of Smac in cephalostatin-induced cell death Cell Death and Differentiation. 15: 1930-1940. PMID 18806754 DOI: 10.1038/Cdd.2008.125  1
2008 Pettit GR, Thornhill AJ, Moser BR, Hogan F. Antineoplastic agents. 552. Oxidation of combretastatin A-1: trapping the o-quinone intermediate considered the metabolic product of the corresponding phosphate prodrug. Journal of Natural Products. 71: 1561-3. PMID 18729517 DOI: 10.1021/Np800179G  1
2008 Hall JJ, Sriram M, Strecker TE, Tidmore JK, Jelinek CJ, Kumar GD, Hadimani MB, Pettit GR, Chaplin DJ, Trawick ML, Pinney KG. Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4. Bioorganic & Medicinal Chemistry Letters. 18: 5146-9. PMID 18710804 DOI: 10.1016/J.Bmcl.2008.07.070  1
2008 Schyschka L, Rudy A, Jeremias I, Barth N, Pettit GR, Vollmar AM. Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP Leukemia. 22: 1737-1745. PMID 18548102 DOI: 10.1038/Leu.2008.146  1
2008 Repp KK, Hogan F, Pettit GR, Pettit RK. In vitro interactions of approved and experimental drugs against Candida drugs against Candida spp. Journal of Chemotherapy (Florence, Italy). 20: 137-9. PMID 18343758 DOI: 10.1179/Joc.2008.20.1.137  1
2008 Pettit GR, Hogan F, Xu JP, Tan R, Nogawa T, Cichacz Z, Pettit RK, Du J, Ye QH, Cragg GM, Herald CL, Hoard MS, Goswami A, Searcy J, Tackett L, et al. Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). Journal of Natural Products. 71: 438-44. PMID 18327911 DOI: 10.1021/Np700738K  1
2008 Siles R, Ackley JF, Hadimani MB, Hall JJ, Mugabe BE, Guddneppanavar R, Monk KA, Chapuis JC, Pettit GR, Chaplin DJ, Edvardsen K, Trawick ML, Garner CM, Pinney KG. Combretastatin dinitrogen-substituted stilbene analogues as tubulin-binding and vascular-disrupting agents. Journal of Natural Products. 71: 313-20. PMID 18303849 DOI: 10.1021/Np070377J  1
2008 James C, Pettit GR, Nielsen OF, Jayakumar VS, Joe IH. Vibrational spectra and ab initio molecular orbital calculations of the novel anti-cancer drug combretastatin A-4 prodrug Spectrochimica Acta - Part a: Molecular and Biomolecular Spectroscopy. 70: 1208-1216. PMID 18248845 DOI: 10.1016/J.Saa.2007.10.052  1
2008 Smith AB, Razler TM, Meis RM, Pettit GR. Synthesis and biological evaluation of phorboxazole congeners leading to the discovery and preparative-scale synthesis of (+)-chlorophorboxazole a possessing picomolar human solid tumor cell growth inhibitory activity. The Journal of Organic Chemistry. 73: 1201-8. PMID 18215059 DOI: 10.1021/Jo701816H  1
2008 Brennan MR, Costello CE, Maleknia SD, Pettit GR, Erickson KL. Stylopeptide 2, a proline-rich cyclodecapeptide from the sponge Stylotella sp. Journal of Natural Products. 71: 453-6. PMID 18197605 DOI: 10.1021/Np0704856  1
2008 Pettit GR, Mukku VJ, Cragg G, Herald DL, Knight JC, Herald CL, Chapuis JC. Antineoplastic agents. 558. Ampelocissus sp. cancer cell growth inhibitory constituents. Journal of Natural Products. 71: 130-3. PMID 18177007 DOI: 10.1021/Np068050Q  1
2007 Shnyder SD, Cooper PA, Millington NJ, Pettit GR, Bibby MC. Auristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models International Journal of Oncology. 31: 353-360. PMID 17611692  1
2007 Pettit GR, Smith TH, Feng S, Knight JC, Tan R, Pettit RK, Hinrichs PA. Antineoplastic agents. 561. Total synthesis of respirantin. Journal of Natural Products. 70: 1073-83. PMID 17608531 DOI: 10.1021/Np0680735  1
2007 Pettit GR, Tan R, Pettit RK, Smith TH, Feng S, Doubek DL, Richert L, Hamblin J, Weber C, Chapuis JC. Antineoplastic agents. 560. Isolation and structure of kitastatin 1 from an Alaskan Kitasatospora sp. Journal of Natural Products. 70: 1069-72. PMID 17608530 DOI: 10.1021/Np068072C  1
2007 Pettit GR, Melody N, Herald DL, Knight JC, Chapuis JC. Antineoplastic agents. 550. Synthesis of 10b(s)-epipancratistatin from (+)-narciclasine. Journal of Natural Products. 70: 417-22. PMID 17346078 DOI: 10.1021/Np068046E  1
2006 López-Antón N, Rudy A, Barth N, Schmitz ML, Schmitz LM, Pettit GR, Schulze-Osthoff K, Dirsch VM, Vollmar AM. The marine product cephalostatin 1 activates an endoplasmic reticulum stress-specific and apoptosome-independent apoptotic signaling pathway. The Journal of Biological Chemistry. 281: 33078-86. PMID 16945918 DOI: 10.1074/Jbc.M607904200  1
2006 Dabydeen DA, Burnett JC, Bai R, Verdier-Pinard P, Hickford SJ, Pettit GR, Blunt JW, Munro MH, Gussio R, Hamel E. Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Molecular Pharmacology. 70: 1866-75. PMID 16940412 DOI: 10.1124/Mol.106.026641  1
2006 Pettit GR, Du J, Pettit RK, Richert LA, Hogan F, Mukku VJ, Hoard MS. Antineoplastic Agents. 554. The manitoba bacterium Streptomyces sp. Journal of Natural Products. 69: 804-6. PMID 16724845 DOI: 10.1021/Np058087V  1
2006 Pettit GR, Numata A, Iwamoto C, Usami Y, Yamada T, Ohishi H, Cragg GM. Antineoplastic agents. 551. Isolation and structures of bauhiniastatins 1-4 from Bauhinia purpurea. Journal of Natural Products. 69: 323-7. PMID 16562827 DOI: 10.1021/Np058075+  1
2006 Smith AB, Razler TM, Meis RM, Pettit GR. Design and synthesis of a potent phorboxazole C(11-15) acetal analogue. Organic Letters. 8: 797-9. PMID 16468770 DOI: 10.1021/Ol060014V  1
2006 LaMarca HL, Morris CA, Pettit GR, Nagowa T, Puschett JB. Marinobufagenin impairs first trimester cytotrophoblast differentiation. Placenta. 27: 984-8. PMID 16458353 DOI: 10.1016/J.Placenta.2005.12.004  1
2006 Vu H, Ianosi-Irimie M, Danchuk S, Rabon E, Nogawa T, Kamano Y, Pettit GR, Wiese T, Puschett JB. Resibufogenin corrects hypertension in a rat model of human preeclampsia. Experimental Biology and Medicine (Maywood, N.J.). 231: 215-20. PMID 16446498  1
2006 Monk KA, Siles R, Hadimani MB, Mugabe BE, Ackley JF, Studerus SW, Edvardsen K, Trawick ML, Garner CM, Rhodes MR, Pettit GR, Pinney KG. Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents. Bioorganic & Medicinal Chemistry. 14: 3231-44. PMID 16442292 DOI: 10.1016/J.Bmc.2005.12.033  1
2006 Pettit GR, Eastham SA, Melody N, Orr B, Herald DL, McGregor J, Knight JC, Doubek DL, Pettit GR, Garner LC, Bell JA. Isolation and structural modification of 7-deoxynarciclasine and 7-deoxy-trans-dihydronarciclasine. Journal of Natural Products. 69: 7-13. PMID 16441059 DOI: 10.1021/Np058068L  1
2006 Hudlicky T, Moser M, Banfield SC, Rinner U, Chapuis JC, Pettit GR. Cyclotrimerization approach to unnatural structural modifications of pancratistatin and other amaryllidaceae constituents - Synthesis and biological evaluation Canadian Journal of Chemistry. 84: 1313-1337. DOI: 10.1139/V06-078  1
2005 Pettit GR, Minardi MD, Rosenberg HJ, Hamel E, Bibby MC, Martin SW, Jung MK, Pettit RK, Cuthbertson TJ, Chapuis JC. Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1). Journal of Natural Products. 68: 1450-8. PMID 16252907 DOI: 10.1021/Np058038I  1
2005 Smith AB, Razler TM, Pettit GR, Chapuis JC. (+)-Phorboxazole A synthetic studies. Identification of a series of highly cytotoxic C(45-46) analogues. Organic Letters. 7: 4403-6. PMID 16178544 DOI: 10.1021/Ol051585A  1
2005 Pettit RK, Woyke T, Pon S, Cichacz ZA, Pettit GR, Herald CL. In vitro and in vivo antifungal activities of the marine sponge constituent spongistatin. Medical Mycology. 43: 453-63. PMID 16178375 DOI: 10.1080/13693780500050598  1
2005 Pettit GR, Meng Y, Herald DL, Knight JC, Day JF. Antineoplastic agents. 553. The Texas grasshopper Brachystola magna. Journal of Natural Products. 68: 1256-8. PMID 16124772 DOI: 10.1021/Np0402367  1
2005 Pettit GR, Tan R, Cichacz ZA. Antineoplastic agents. 542. Isolation and structure of sesterstatin 6 from the Indian Ocean sponge Hyrtios erecta. Journal of Natural Products. 68: 1253-5. PMID 16124771 DOI: 10.1021/Np0402221  1
2005 Pettit GR, Anderson CR, Gapud EJ, Jung MK, Knight JC, Hamel E, Pettit RK. Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene. Journal of Natural Products. 68: 1191-7. PMID 16124759 DOI: 10.1021/Np058033L  1
2005 Pettit GR, Meng Y, Herald DL, Stevens AM, Pettit RK, Doubek DL. Antineoplastic agents 540. The Indian Gynandropsis gynandra (Capparidaceae). Oncology Research. 15: 59-68. PMID 16119003 DOI: 10.3727/096504005775082039  1
2005 Pettit GR, Tang Y, Knight JC. Antineoplastic agents. 545. Isolation and structure of turbostatins 1-4 from the Asian marine mollusk Turbo stenogyrus. Journal of Natural Products. 68: 974-8. PMID 16038534 DOI: 10.1021/Np040107Q  1
2005 Pettit RK, Weber CA, Kean MJ, Hoffmann H, Pettit GR, Tan R, Franks KS, Horton ML. Microplate Alamar blue assay for Staphylococcus epidermidis biofilm susceptibility testing. Antimicrobial Agents and Chemotherapy. 49: 2612-7. PMID 15980327 DOI: 10.1128/Aac.49.7.2612-2617.2005  1
2005 Pettit GR, Rhodes MR, Herald DL, Hamel E, Schmidt JM, Pettit RK. Antineoplastic agents. 445. Synthesis and evaluation of structural modifications of (Z)- and (E)-combretastatin A-41. Journal of Medicinal Chemistry. 48: 4087-99. PMID 15943482 DOI: 10.1021/Jm0205797  1
2005 Pettit GR, Zhang Q, Pinilla V, Hoffmann H, Knight JC, Doubek DL, Chapuis JC, Pettit RK, Schmidt JM. Antineoplastic agents. 534. isolation and structure of sansevistatins 1 and 2 from the African Sansevieria ehrenbergii. Journal of Natural Products. 68: 729-33. PMID 15921418 DOI: 10.1021/Np040203R  1
2005 Ali MA, Bates RB, Crane ZD, Dicus CW, Gramme MR, Hamel E, Marcischak J, Martinez DS, McClure KJ, Nakkiew P, Pettit GR, Stessman CC, Sufi BA, Yarick GV. Dolastatin 11 conformations, analogues and pharmacophore. Bioorganic & Medicinal Chemistry. 13: 4138-52. PMID 15878670 DOI: 10.1016/J.Bmc.2005.04.040  1
2005 Pettit GR, Ducki S, Herald DL, Doubek DL, Schmidt JM, Chapuis JC. Antineoplastic agents 470. Absolute configuration of the marine sponge bromopyrrole agelastatin A. Oncology Research. 15: 11-20. PMID 15839302 DOI: 10.3727/096504005775082075  1
2005 Pettit GR, Melody N. Antineoplastic agents. 527. Synthesis of 7-deoxynarcistatin, 7-deoxy-trans-dihydronarcistatin, and trans-dihydronarcistatin 1(1). Journal of Natural Products. 68: 207-11. PMID 15730244 DOI: 10.1021/Np0304518  1
2005 Müller IM, Dirsch VM, Rudy A, López-Antón N, Pettit GR, Vollmar AM. Cephalostatin 1 inactivates Bcl-2 by hyperphosphorylation independent of M-phase arrest and DNA damage. Molecular Pharmacology. 67: 1684-9. PMID 15703383 DOI: 10.1124/Mol.104.004234  1
2005 Pettit GR, Tan R. Isolation and structure of phakellistatin 14 from the Western Pacific marine sponge Phakellia sp. Journal of Natural Products. 68: 60-3. PMID 15679318 DOI: 10.1021/Np040092W  1
2004 Suggitt M, Swaine DJ, Pettit GR, Bibby MC. Characterization of the hollow fiber assay for the determination of microtubule disruption in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 6677-85. PMID 15475458 DOI: 10.1158/1078-0432.Ccr-04-0855  1
2004 Rinner U, Hudlicky T, Gordon H, Pettit GR. A beta-carboline-1-one mimic of the anticancer Amaryllidaceae constituent pancratistatin: synthesis and biological evaluation. Angewandte Chemie (International Ed. in English). 43: 5342-6. PMID 15468184 DOI: 10.1002/Anie.200460218  1
2004 Pettit GR, Nogawa T, Knight JC, Doubek DL, Hooper JN. Antineoplastic agents. 535. Isolation and structure of plakorstatins 1 and 2 from the Indo-Pacific sponge Plakortis nigra. Journal of Natural Products. 67: 1611-3. PMID 15387674 DOI: 10.1021/Np040043J  1
2004 Pettit GR, Tan R, Northen JS, Herald DL, Chapuis JC, Pettit RK. Antineoplastic agents. 529. Isolation and structure of nootkastatins 1 and 2 from the Alaskan yellow cedar Chamaecyparis nootkatensis. Journal of Natural Products. 67: 1476-82. PMID 15387645 DOI: 10.1021/Np0304161  1
2004 Pettit GR, Xu JP, Doubek DL, Chapuis JC, Schmidt JM. Antineoplastic Agents. 510. Isolation and structure of dolastatin 19 from the Gulf of California sea hare Dolabella auricularia. Journal of Natural Products. 67: 1252-5. PMID 15332837 DOI: 10.1021/Np030198B  1
2004 Pettit GR, Zhang Q, Pinilla V, Herald DL, Doubek DL, Duke JA. Isolation and structure of gustastatin from the Brazilian nut tree Gustavia hexapetala. Journal of Natural Products. 67: 983-5. PMID 15217278 DOI: 10.1021/Np030509I  1
2004 Pettit GR, Hogan F, Herald DL. Synthesis and X-ray crystal structure of the dolabellaauricularia peptide dolastatin 18. The Journal of Organic Chemistry. 69: 4019-22. PMID 15176826 DOI: 10.1021/Jo030358O  1
2004 Rinner U, Hillebrenner HL, Adams DR, Hudlicky T, Pettit GR. Synthesis and biological activity of some structural modifications of pancratistatin. Bioorganic & Medicinal Chemistry Letters. 14: 2911-5. PMID 15125958 DOI: 10.1016/J.Bmcl.2004.03.032  1
2004 Bai R, Covell DG, Taylor GF, Kepler JA, Copeland TD, Nguyen NY, Pettit GR, Hamel E. Direct photoaffinity labeling by dolastatin 10 of the amino-terminal peptide of beta-tubulin containing cysteine 12. The Journal of Biological Chemistry. 279: 30731-40. PMID 15123603 DOI: 10.1074/Jbc.M402110200  1
2004 Pettit GR, Hoffmann H, Herald DL, McNulty J, Murphy A, Higgs KC, Hamel E, Lewin NE, Pearce LV, Blumberg PM, Pettit RK, Knight JC. Antineoplastic agents 491. Synthetic conversion of aaptamine to isoaaptamine, 9-demethylaaptamine, and 4-methylaaptamine. The Journal of Organic Chemistry. 69: 2251-6. PMID 15049616 DOI: 10.1021/Jo0300486  1
2004 Pettit GR, Hoffmann H, McNulty J, Higgs KC, Murphy A, Molloy DJ, Herald DL, Williams MD, Pettit RK, Doubek DL, Hooper JN, Albright L, Schmidt JM, Chapuis JC, Tackett LP. Antineoplastic agents. 380. Isolation and X-ray crystal structure determination of isoaaptamine from the Republic of Singapore Hymeniacidon sp. and conversion to the phosphate prodrug hystatin 1. Journal of Natural Products. 67: 506-9. PMID 15043446 DOI: 10.1021/Np0204592  1
2004 Pettit GR, Melody N, Herald DL. Antineoplastic agents. 511. Direct phosphorylation of phenpanstatin and pancratistatin. Journal of Natural Products. 67: 322-7. PMID 15043403 DOI: 10.1021/Np030299+  1
2004 Pettit GR, Hoffmann H, Herald DL, Blumberg PM, Hamel E, Schmidt JM, Chang Y, Pettit RK, Lewin NE, Pearce LV. Antineoplastic agents. 499. Synthesis of hystatin 2 and related 1H-benzo[de][1,6]-naphthyridinium salts from aaptamine. Journal of Medicinal Chemistry. 47: 1775-82. PMID 15027869 DOI: 10.1021/Jm030070R  1
2004 Pettit GR, Meng Y, Gearing RP, Herald DL, Pettit RK, Doubek DL, Chapuis JC, Tackett LP. Antineoplastic agents. 522. Hernandia peltata (Malaysia) and Hernandia nymphaeifolia (Republic of Maldives). Journal of Natural Products. 67: 214-20. PMID 14987061 DOI: 10.1021/Np030125S  1
2004 Kirwan IG, Loadman PM, Swaine DJ, Anthoney DA, Pettit GR, Lippert JW, Shnyder SD, Cooper PA, Bibby MC. Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 1446-53. PMID 14977848 DOI: 10.1158/1078-0432.Ccr-0518-03  1
2004 Pettit GR, Xu JP, Chapuis JC, Pettit RK, Tackett LP, Doubek DL, Hooper JN, Schmidt JM. Antineoplastic agents. 520. Isolation and structure of irciniastatins A and B from the Indo-Pacific marine sponge Ircinia ramosa. Journal of Medicinal Chemistry. 47: 1149-52. PMID 14971894 DOI: 10.1021/Jm030207D  1
2004 Woyke T, Berens ME, Hoelzinger DB, Pettit GR, Winkelmann G, Pettit RK. Differential gene expression in auristatin PHE-treated Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. 48: 561-7. PMID 14742210 DOI: 10.1128/Aac.48.2.561-567.2004  1
2004 Dang LH, Bettegowda C, Agrawal N, Cheong I, Huso D, Frost P, Loganzo F, Greenberger L, Barkoczy J, Pettit GR, Smith AB, Gurulingappa H, Khan S, Parmigiani G, Kinzler KW, et al. Targeting vascular and avascular compartments of tumors with C. novyi-NT and anti-microtubule agents Cancer Biology and Therapy. 3: 326-337. PMID 14739784 DOI: 10.4161/Cbt.3.3.704  1
2004 Pettit RK, Fakoury BR, Knight JC, Weber CA, Pettit GR, Cage GD, Pon S. Antibacterial activity of the marine sponge constituent cribrostatin 6. Journal of Medical Microbiology. 53: 61-5. PMID 14663107 DOI: 10.1099/Jmm.0.05250-0  1
2004 Binoy J, Abraham JP, Joe IH, Jayakumar VS, Pettit GR, Nielsen OF. NIR-FT Raman and FT-IR spectral studies and ab initio calculations of the anti-cancer drug combretastatin-A4 Journal of Raman Spectroscopy. 35: 939-946. DOI: 10.1002/Jrs.1236  1
2004 Meilert K, Pettit GR, Vogel P. Non-iterative asymmetric synthesis of C15 polyketide spiroketals Helvetica Chimica Acta. 87: 1493-1507. DOI: 10.1002/Hlca.200490136  1
2003 Dirsch VM, Müller IM, Eichhorst ST, Pettit GR, Kamano Y, Inoue M, Xu JP, Ichihara Y, Wanner G, Vollmar AM. Cephalostatin 1 selectively triggers the release of Smac/DIABLO and subsequent apoptosis that is characterized by an increased density of the mitochondrial matrix. Cancer Research. 63: 8869-76. PMID 14695204  1
2003 Cruz-Monserrate Z, Mullaney JT, Harran PG, Pettit GR, Hamel E. Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography European Journal of Biochemistry. 270: 3822-3828. PMID 12950266 DOI: 10.1046/J.1432-1033.2003.03776.X  1
2003 Pettit GR, Meng Y, Herald DL, Graham KA, Pettit RK, Doubek DL. Isolation and structure of ruprechstyril from Ruprechtia tangarana. Journal of Natural Products. 66: 1065-9. PMID 12932125 DOI: 10.1021/Np0300986  1
2003 Shnyder SD, Cooper PA, Pettit GR, Lippert JW, Bibby MC. Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model Anticancer Research. 23: 1619-1623. PMID 12820431  1
2003 Hua J, Sheng Y, Pinney KG, Garner CM, Kane RR, Prezioso JA, Pettit GR, Chaplin DJ, Edvardsen K. Oxi4503, a novel vascular targeting agent: effects on blood flow and antitumor activity in comparison to combretastatin A-4 phosphate. Anticancer Research. 23: 1433-40. PMID 12820406  1
2003 Ali S, Aranha O, Li Y, Pettit GR, Sarkar FH, Philip PA. Sensitization of human breast cancer cells to gemcitabine by the protein kinase C modulator bryostatin 1. Cancer Chemotherapy and Pharmacology. 52: 235-46. PMID 12811511 DOI: 10.1007/S00280-003-0628-6  1
2003 Pettit GR, Collins JC, Knight JC, Herald DL, Nieman RA, Williams MD, Pettit RK. Antineoplastic agents. 485. Isolation and structure of cribrostatin 6, a dark blue cancer cell growth inhibitor from the marine sponge Cribrochalina sp. Journal of Natural Products. 66: 544-7. PMID 12713412 DOI: 10.1021/Np020012T  1
2003 Fennell BJ, Carolan S, Pettit GR, Bell A. Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum Journal of Antimicrobial Chemotherapy. 51: 833-841. PMID 12654761 DOI: 10.1093/Jac/Dkg151  1
2003 Pettit GR, Tan R. Antineoplastic agents 390. Isolation and structure of phakellistatin 12 from a Chuuk archipelago marine sponge. Bioorganic & Medicinal Chemistry Letters. 13: 685-8. PMID 12639558 DOI: 10.1016/S0960-894X(01)80695-8  1
2003 Pettit GR, Tan R, Herald DL, Hamblin J, Pettit RK. Antineoplastic agents. 488. Isolation and structure of yukonin from a yukon territory fungus. Journal of Natural Products. 66: 276-8. PMID 12608865 DOI: 10.1021/Np020144M  1
2003 Pettit GR, Meng Y, Stevenson CA, Doubek DL, Knight JC, Cichacz Z, Pettit RK, Chapuis JC, Schmidt JM. Isolation and structure of palstatin from the Amazon tree Hymeneae palustris(1). Journal of Natural Products. 66: 259-62. PMID 12608861 DOI: 10.1021/Np020231E  1
2003 Pettit GR, Anderson CR, Herald DL, Jung MK, Lee DJ, Hamel E, Pettit RK. Antineoplastic agents. 487. Synthesis and biological evaluation of the antineoplastic agent 3,4-methylenedioxy-5,4'-dimethoxy-3'-amino-Z-stilbene and derived amino acid amides. Journal of Medicinal Chemistry. 46: 525-31. PMID 12570374 DOI: 10.1021/Jm020204L  1
2003 Pettit GR, Melody N, Simpson M, Thompson M, Herald DL, Knight JC. Antineoplastic agents 500. Narcistatin. Journal of Natural Products. 66: 92-6. PMID 12542352 DOI: 10.1021/Np020225I  1
2003 Smith AB, Cho YS, Pettit GR, Hirschmann R. Design, synthesis, and evaluation of azepine-based cryptophycin mimetics Tetrahedron. 59: 6991-7009. DOI: 10.1016/S0040-4020(03)00857-3  1
2002 Holwell SE, Cooper PA, Thompson MJ, Pettit GR, Lippert JW, Martin SW, Bibby MC. Anti-tumor and anti-vascular effects of the novel tubulin-binding agent combretastatin A-1 phosphate Anticancer Research. 22: 3933-3940. PMID 12553015  1
2002 Pettit GR, Numata A, Iwamoto C, Morito H, Yamada T, Goswami A, Clewlow PJ, Cragg GM, Schmidt JM. Antineoplastic agents. 489. Isolation and structures of meliastatins 1-5 and related euphane triterpenes from the tree Melia dubia. Journal of Natural Products. 65: 1886-91. PMID 12502333 DOI: 10.1021/np020216+  1
2002 Bai R, Bates RB, Hamel E, Moore RE, Nakkiew P, Pettit GR, Sufi BA. Lyngbyastatin 1 and Ibu-epilyngbyastatin 1: synthesis, stereochemistry, and NMR line broadening. Journal of Natural Products. 65: 1824-9. PMID 12502322 DOI: 10.1021/Np020117W  1
2002 Pettit GR, Knight JC, Herald DL, Davenport R, Pettit RK, Tucker BE, Schmidt JM. Isolation of labradorins 1 and 2 from Pseudomonas syringae pv. coronafaciens. Journal of Natural Products. 65: 1793-7. PMID 12502316 DOI: 10.1021/Np020173X  1
2002 Hudlicky T, Rinner U, Gonzalez D, Akgun H, Schilling S, Siengalewicz P, Martinot TA, Pettit GR. Total synthesis and biological evaluation of Amaryllidaceae alkaloids: narciclasine, ent-7-deoxypancratistatin, regioisomer of 7-deoxypancratistatin, 10b-epi-deoxypancratistatin, and truncated derivatives. The Journal of Organic Chemistry. 67: 8726-43. PMID 12467383 DOI: 10.1021/Jo020129M  1
2002 Kamano Y, Yamashita A, Nogawa T, Morita H, Takeya K, Itokawa H, Segawa T, Yukita A, Saito K, Katsuyama M, Pettit GR. Qsar evaluation of the Ch'an Su and related bufadienolides against the colchicine-resistant primary liver carcinoma cell line PLC/PRF/5 Journal of Medicinal Chemistry. 45: 5440-5447. PMID 12459012 DOI: 10.1021/Jm0202066  1
2002 Woyke T, Roberson RW, Pettit GR, Winkelmann G, Pettit RK. Effect of auristatin PHE on microtubule integrity and nuclear localization in Cryptococcus neoformans. Antimicrobial Agents and Chemotherapy. 46: 3802-8. PMID 12435680 DOI: 10.1128/Aac.46.12.3802-3808.2002  1
2002 Pettit GR, Ducki S, Tan R, Gardella RS, McMahon JB, Boyd MR, Pettit GR, Blumberg PM, Lewin NE, Doubek DL, Tackett LP, Williams MD. Isolation and structure of pedilstatin from a republic of maldives Pedilanthus sp. Journal of Natural Products. 65: 1262-5. PMID 12350143 DOI: 10.1021/Np020115B  1
2002 Nabha SM, Mohammad RM, Dandashi MH, Coupaye-Gerard B, Aboukameel A, Pettit GR, Al-Katib AM. Combretastatin-A4 prodrug induces mitotic catastrophe in chronic lymphocytic leukemia cell line independent of caspase activation and poly(ADP-ribose) polymerase cleavage. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 8: 2735-41. PMID 12171907  1
2002 Hill SA, Toze GM, Pettit GR, Chaplin DJ. Preclinical evaluation of the antitumour activity of the novel vascular targeting agent Oxi 4503. Anticancer Research. 22: 1453-8. PMID 12168822  1
2002 Kamano Y, Nogawa T, Yamashita A, Hayashi M, Inoue M, Drašar P, Pettit GR. Isolation and structure of a 20,21-epoxybufenolide series from "Ch'an Su", Journal of Natural Products. 65: 1001-1005. PMID 12141860 DOI: 10.1021/Np0200360  1
2002 Smith AB, Corbett RM, Pettit GR, Chapuis JC, Schmidt JM, Hamel E, Jung MK. Synthesis and biological evaluation of a spongistatin AB-spiroketal analogue. Bioorganic & Medicinal Chemistry Letters. 12: 2039-42. PMID 12113837 DOI: 10.1016/S0960-894X(02)00305-0  1
2002 Pettit GR, Grealish MP, Jung MK, Hamel E, Pettit RK, Chapuis JC, Schmidt JM. Antineoplastic agents. 465. Structural modification of resveratrol: sodium resverastatin phosphate. Journal of Medicinal Chemistry. 45: 2534-42. PMID 12036362 DOI: 10.1021/Jm010119Y  1
2002 Holwell SE, Cooper PA, Grosios K, Lippert JW, Pettit GR, Shnyder SD, Bibby MC. Combretastatin A-1 phosphate a novel tubulin-binding agent with in vivo anti vascular effects in experimental tumours Anticancer Research. 22: 707-711. PMID 12017147  1
2002 Pettit RK, Hamel E, Verdier-Pinard P, Roberson RW, Hazen KC, Pettit GR, Crews LC. Antifungal and cancer cell growth inhibitory activities of 1-(3′,4′,5′-trimethoxyphenyl)-2-nitro-ethylene Mycoses. 45: 65-74. PMID 12000503 DOI: 10.1046/J.1439-0507.2002.00722.X  1
2002 Thamm DH, MacEwen GE, Phillips BS, Hershey EA, Burgess KM, Pettit GR, Vail DM. Preclinical study of dolastatin-10 in dogs with spontaneous neoplasia Cancer Chemotherapy and Pharmacology. 49: 251-255. PMID 11935218 DOI: 10.1007/S00280-001-0402-6  1
2002 Pettit GR, Melody N, Herald DL, Schmidt JM, Pettit RK, Chapuis JC. Synthesis of 10b(R)-hydroxypancratistatin, 10b(S)-hydroxy-1-epipancratistatin, 10b(S)-hydroxy-1,2-diepipancratistatin and related isocarbostyrils Heterocycles. 56: 139-155. DOI: 10.3987/Com-01-S(K)7  1
2002 Pettit GR. Heterocycles: Preface Heterocycles. 56: 1.  1
2001 Pettit GR, Moser BR, Boyd MR, Schmidt JM, Pettit RK, Chapuis JC. Antineoplastic agents 460. Synthesis of combretastatin A-2 prodrugs. Anti-Cancer Drug Design. 16: 185-93. PMID 12049477  1
2001 Smith AB, Cho YS, Zawacki LE, Hirschmann R, Pettit GR. First generation design, synthesis, and evaluation of azepine-based cryptophycin analogues Organic Letters. 3: 4063-4066. PMID 11735585 DOI: 10.1021/Ol016799G  1
2001 Pettit GR, Grealish MP. A cobalt-phosphine complex directed Reformatsky approach to a stereospecific synthesis of the dolastatin 10 unit dolaproine (Dap). The Journal of Organic Chemistry. 66: 8640-2. PMID 11735549 DOI: 10.1021/Jo010530T  1
2001 Woyke T, Pettit GR, Winkelmann G, Pettit RK. In vitro activities and postantifungal effects of the potent dolastatin 10 derivative auristatin PHE Antimicrobial Agents and Chemotherapy. 45: 3580-3584. PMID 11709343 DOI: 10.1128/Aac.45.12.3580-3584.2001  1
2001 Ouarzane-Amara M, Franetich JF, Mazier D, Pettit GR, Meijer L, Doerig C, Desportes-Livage I. In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans. Antimicrobial Agents and Chemotherapy. 45: 3409-15. PMID 11709316 DOI: 10.1128/Aac.45.12.3409-3415.2001  1
2001 Mohammad RM, Adsay NV, Philip PA, Pettit GR, Vaitkevicius VK, Sarkar FH. Bryostatin 1 induces differentiation and potentiates the antitumor effect of Auristatin PE in a human pancreatic tumor (PANC-1) xenograft model Anti-Cancer Drugs. 12: 735-740. PMID 11593055 DOI: 10.1097/00001813-200110000-00005  1
2001 Nogawa T, Kamano Y, Yamashita A, Pettit GR. Isolation and structure of five new cancer cell growth inhibitory bufadienolides from the Chinese traditional drug Ch'an Su Journal of Natural Products. 64: 1148-1152. PMID 11575946 DOI: 10.1021/Np0101088  1
2001 Pettit GR, Lippert JW, Taylor SR, Tan R, Williams MD. Synthesis of phakellistatin 11: A Micronesia (Chuuk) marine sponge cyclooctapeptide Journal of Natural Products. 64: 883-891. PMID 11473416 DOI: 10.1021/Np0100441  1
2001 Duffield JJ, Pettit GR. Synthesis of (7S,15S)- and (7R,15S)-dolatrienoic acid. Journal of Natural Products. 64: 472-9. PMID 11325230 DOI: 10.1021/Np000502Q  1
2001 Pettit GR, Melody N, Herald DL. Antineoplastic agents. 450. Synthesis of (+)-pancratistatin from (+)-narciclasine as relay Journal of Organic Chemistry. 66: 2583-2587. PMID 11304174 DOI: 10.1021/Jo000710N  1
2001 Nabha SM, Mohammad RM, Wall NR, Dutcher JA, Salkini BM, Pettit GR, Al-Katib AM. Evaluation of combretastatin A-4 prodrug in a non-Hodgkin's lymphoma xenograft model: Preclinical efficacy Anti-Cancer Drugs. 12: 57-63. PMID 11272287 DOI: 10.1097/00001813-200101000-00008  1
2001 McNulty J, Mao J, Gibe R, Mo R, Wolf S, Pettit GR, Herald DL, Boyd MR. Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore. Bioorganic & Medicinal Chemistry Letters. 11: 169-72. PMID 11206451 DOI: 10.1016/S0960-894X(00)00614-4  1
2001 Bai R, Verdier-Pinard P, Gangwar S, Stessman CC, McClure KJ, Sausville EA, Pettit GR, Bates RB, Hamel E. Dolastatin 11, a marine depsipeptide, arrests cells at cytokinesis and induces hyperpolymerization of purified actin. Molecular Pharmacology. 59: 462-9. PMID 11179440 DOI: 10.1124/Mol.59.3.462  1
2001 Kamano Y, Nogawa T, Yamashita A, Pettit GR. The 1H and 13C NMR chemical shift assignments for thirteen bufadienolides isolated from the traditional Chinese drug Ch'an Su Collection of Czechoslovak Chemical Communications. 66: 1841-1848.  1
2000 Pettit GR, Minardi MD, Boyd MR, Pettit RK. Antineoplastic agents 463. Synthesis of combretastatin A-3 diphosphate prodrugs Anti-Cancer Drug Design. 15: 397-403. PMID 11716432  1
2000 Pettit GR, Orr B, Ducki S. Antineoplastic agents 453. Synthesis of pancratistatin prodrugs Anti-Cancer Drug Design. 15: 389-395. PMID 11716431  1
2000 Pettit GR, Lippert JW, Boyd MR, Verdier-Pinard P, Hamel E. Antineoplastic agents 442. Synthesis and biological activities of dioxostatin. Anti-Cancer Drug Design. 15: 361-71. PMID 11354312  1
2000 Chen Z, Mocharla VP, Farmer JM, Pettit GR, Hamel E, Pinney KG. Preparation of new anti-tubulin ligands through a dual-mode, addition-elimination reaction to a bromo-substituted alpha, beta-unsaturated sulfoxide. The Journal of Organic Chemistry. 65: 8811-5. PMID 11112609 DOI: 10.1021/Jo0004761  1
2000 Clarke H, Ginanni N, Laughlin KV, Smith JB, Pettit GR, Mullin JM. The transient increase of tight junction permeability induced by bryostatin 1 correlates with rapid downregulation of protein kinase C-alpha. Experimental Cell Research. 261: 239-49. PMID 11082294 DOI: 10.1006/Excr.2000.5035  1
2000 Pettit GR, Lippert JW, Herald DL. A Pinacol rearrangement/oxidation synthetic route to hydroxyphenstatin Journal of Organic Chemistry. 65: 7438-7444. PMID 11076601 DOI: 10.1021/Jo000705J  1
2000 Pinney KG, Mejia MP, Villalobos VM, Rosenquist BE, Pettit GR, Verdier-Pinard P, Hamel E. Synthesis and biological evaluation of aryl azide derivatives of combretastatin A-4 as molecular probes for tubulin. Bioorganic & Medicinal Chemistry. 8: 2417-25. PMID 11058036 DOI: 10.1016/S0968-0896(00)00176-0  1
2000 Pettit GR, Lippert JW. Antineoplastic agents 429. Syntheses of the combretastatin A-1 and combretastatin B-1 prodrugs Anti-Cancer Drug Design. 15: 203-216. PMID 11049088  1
2000 Chen C, Lin H, Karanes C, Pettit GR, Chen BD. Human THP-1 monocytic leukemic cells induced to undergo monocytic differentiation by bryostatin 1 are refractory to proteasome inhibitor-induced apoptosis Cancer Research. 60: 4377-4385. PMID 10969781  1
2000 Pettit RK, Cage GD, Pettit GR, Liebman JA. Antimicrobial and cancer cell growth inhibitory activities of 3beta-acetoxy-17beta-(L-prolyl)amino-5alpha-androstane in vitro. International Journal of Antimicrobial Agents. 15: 299-304. PMID 10929880 DOI: 10.1016/S0924-8579(00)00156-4  1
2000 Pettit GR, Lippert JW, Herald DL, Hamel E, Pettit RK. Antineoplastic agents 440. Asymmetric synthesis and evaluation of the combretastatin A-1 SAR probes (1S,2S)- and (1R,2R)-1,2-dihydroxy-1-(2',3'-dihydroxy-4'-methoxyphenyl)-2-(3'' ,4'',5''-trimethoxyphenyl)-ethane Journal of Natural Products. 63: 969-974. PMID 10924176 DOI: 10.1021/Np0000623  1
2000 Nabha SM, Wall NR, Mohammad RM, Pettit GR, Al-Katib AM. Effects of Combretastatin A-4 prodrug against a panel of malignant human B-lymphoid cell lines Anti-Cancer Drugs. 11: 385-392. PMID 10912955 DOI: 10.1097/00001813-200006000-00009  1
2000 Pettit GR, Grealish MP, Herald DL, Boyd MR, Hamel E, Pettit RK. Antineoplastic agents. 443. Synthesis of the cancer cell growth inhibitor hydroxyphenstatin and its sodium diphosphate prodrug. Journal of Medicinal Chemistry. 43: 2731-7. PMID 10893310 DOI: 10.1021/Jm000045A  1
2000 He Z, Evelhoch JL, Mohammad RM, Adsay NV, Pettit GR, Vaitkevicius VK, Sarkar FH. Magnetic resonance imaging to measure therapeutic response using an orthotopic model of human pancreatic cancer Pancreas. 21: 69-76. PMID 10881935 DOI: 10.1097/00006676-200007000-00054  1
2000 Pettit GR, Knight JC, Collins JC, Herald DL, Pettit RK, Boyd MR, Young VG. Antineoplastic agents 430. Isolation and structure of cribrostatins 3, 4, and 5 from the republic of maldives cribrochalina species. Journal of Natural Products. 63: 793-8. PMID 10869203 DOI: 10.1021/Np990618Q  1
2000 Beutler JA, McCall KL, Herbert K, Herald DL, Pettit GR, Johnson T, Shoemaker RH, Boyd MR. Novel cytotoxic diterpenes from Casearia arborea. Journal of Natural Products. 63: 657-61. PMID 10843580 DOI: 10.1021/Np990553R  1
2000 Lorenzo PS, Beheshti M, Pettit GR, Stone JC, Blumberg PM. The guanine nucleotide exchange factor RasGRP is a high-affinity target for diacylglycerol and phorbol esters Molecular Pharmacology. 57: 840-846. PMID 10779365  1
2000 Grosios K, Loadman PM, Swaine DJ, Pettit GR, Bibby MC. Combination chemotherapy with combretastatin A-4 phosphate and 5-fluorouracil in an experimental murine colon adenocarcinoma Anticancer Research. 20: 229-233. PMID 10769660  1
2000 Meijer L, Thunnissen AM, White AW, Garnier M, Nikolic M, Tsai LH, Walter J, Cleverley KE, Salinas PC, Wu YZ, Biernat J, Mandelkow EM, Kim SH, Pettit GR. Inhibition of cyclin-dependent kinases, GSK-3beta and CK1 by hymenialdisine, a marine sponge constituent. Chemistry & Biology. 7: 51-63. PMID 10662688 DOI: 10.1016/S1074-5521(00)00063-6  1
2000 Pettit GR, Numata A, Cragg GM, Herald DL, Takada T, Iwamoto C, Riesen R, Schmidt JM, Doubek DL, Goswami A. Isolation and structures of schleicherastatins 1-7 and schleicheols 1 and 2 from the teak forest medicinal tree Schleichera oleosa. Journal of Natural Products. 63: 72-8. PMID 10650082 DOI: 10.1021/Np990346R  1
2000 Pettit GR, Toki BE, Xu JP, Brune DC. Synthesis of the marine sponge cycloheptapeptide phakellistatin 5(1). Journal of Natural Products. 63: 22-8. PMID 10650072 DOI: 10.1021/Np990253+  1
2000 Verdier-Pinard P, Kepler JA, Pettit GR, Hamel E. Sustained intracellular retention of dolastatin 10 causes its potent antimitotic activity. Molecular Pharmacology. 57: 180-7. PMID 10617693  1
2000 Kamano Y, Kotake A, Nogawa T, Hiraide H, Pettit GR, Herald CL. Separation of the bryostatin derivatives by high performance liquid chromatography Journal of Liquid Chromatography and Related Technologies. 23: 399-409. DOI: 10.1081/Jlc-100101459  1
2000 Idso SB, Kimball BA, Pettit GR, Garner LC, Backhaus RA. Effects of atmospheric CO2 enrichment on the growth and development of Hymenocallis littoralis (Amaryllidaceae) and the concentrations of several antineoplastic and antiviral constituents of its bulbs American Journal of Botany. 87: 769-773.  1
1999 Lorenzo PS, Bögi K, Hughes KM, Beheshti M, Bhattacharyya D, Garfield SH, Pettit GR, Blumberg PM. Differential roles of the tandem C1 domains of protein kinase C delta in the biphasic down-regulation induced by bryostatin 1. Cancer Research. 59: 6137-44. PMID 10626804  1
1999 Grosios K, Holwell SE, McGown AT, Pettit GR, Bibby MC. In vivo and in vitro evaluation of combretastatin A-4 and its sodium phosphate prodrug British Journal of Cancer. 81: 1318-1327. PMID 10604728 DOI: 10.1038/Sj.Bjc.6692174  1
1999 Wall NR, Mohammad RM, Nabha SM, Pettit GR, Al-Katib AM. Modulation of cIAP-1 by novel antitubulin agents when combined with bryostatin 1 results in increased apoptosis in the human early pre-B acute lymphoblastic leukemia cell line Reh Biochemical and Biophysical Research Communications. 266: 76-80. PMID 10581168 DOI: 10.1006/Bbrc.1999.1768  1
1999 Mohammad RM, Li Y, Mohamed AN, Pettit GR, Adsay V, Vaitkevicius VK, Al-Katib AM, Sarkar FH. Clonal preservation of human pancreatic cell line derived from primary pancreatic adenocarcinoma Pancreas. 19: 353-361. PMID 10547195 DOI: 10.1097/00006676-199911000-00006  1
1999 Détivaud L, Pettit GR, Meijer L. Characterization of a novel cdk1-related kinase. European Journal of Biochemistry / Febs. 264: 55-66. PMID 10447673 DOI: 10.1046/J.1432-1327.1999.00576.X  1
1999 Ovechkina YY, Pettit RK, Cichacz ZA, Pettit GR, Oakley BR. Unusual antimicrotubule activity of the antifungal agent spongistatin 1. Antimicrobial Agents and Chemotherapy. 43: 1993-9. PMID 10428925 DOI: 10.1128/Aac.43.8.1993  1
1999 Mohammad RM, Limvarapuss C, Wall NR, Hamdy N, Beck FW, Pettit GR, Al-Katib A. A new tubulin polymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom's macroglobulinemia xenograft model. International Journal of Oncology. 15: 367-372. PMID 10402249 DOI: 10.3892/Ijo.15.2.367  1
1999 Pettit GR, Tan R, Melody N, Kielty JM, Pettit RK, Herald DL, Tucker BE, Mallavia LP, Doubek DL, Schmidt JM. Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete Bioorganic and Medicinal Chemistry. 7: 895-899. PMID 10400343 DOI: 10.1016/S0968-0896(99)00024-3  1
1999 Pinney KG, Bounds AD, Dingeman KM, Mocharla VP, Pettit GR, Bai R, Hamel E. A new anti-tubulin agent containing the benzo[b]thiophene ring system. Bioorganic & Medicinal Chemistry Letters. 9: 1081-6. PMID 10328289 DOI: 10.1016/S0960-894X(99)00143-2  1
1999 Kalemkerian GP, Ou X, Adil MR, Rosati R, Khoulani MM, Madan SK, Pettit GR. Activity of dolastatin 10 against small-cell lung cancer in vitro and in vivo: Induction of apoptosis and bcl-2 modification Cancer Chemotherapy and Pharmacology. 43: 507-515. PMID 10321512 DOI: 10.1007/S002800050931  1
1999 Chaplin DJ, Pettit GR, Hill SA. Anti-vascular approaches to solid tumour therapy: Evaluation of combretastatin A4 phosphate Anticancer Research. 19: 189-195. PMID 10226542  1
1999 Pettit GR, Toki BE, Herald DL, Boyd MR, Hamel E, Pettit RK, Chapuis JC. Antineoplastic agents. 410. Asymmetric hydroxylation of trans-combretastatin A-4. Journal of Medicinal Chemistry. 42: 1459-65. PMID 10212132 DOI: 10.1021/Jm9807149  1
1999 Bodily JM, Hoopes DJ, Roeder BL, Gilbert SG, Pettit GR, Herald CL, Rollins DN, Robison RA. The inhibitory effects of bryostatin 1 administration on the growth of rabbit papillomas. Cancer Letters. 136: 67-74. PMID 10211941 DOI: 10.1016/S0304-3835(98)00310-3  1
1999 Pettit GR, Rhodes MR, Tan R. Antineoplastic agents. 400. Synthesis of the Indian ocean marine sponge cyclic heptapeptide phakellistatin 2 Journal of Natural Products. 62: 409-414. PMID 10096847 DOI: 10.1021/Np980168M  1
1999 Zhao S, Moore JV, Waller ML, McGown AT, Hadfield JA, Pettit GR, Hastings DL. Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4. European Journal of Nuclear Medicine. 26: 231-8. PMID 10079313 DOI: 10.1007/S002590050382  1
1999 Kamano Y, Morita H, Takano R, Kotake A, Nogawa T, Hashima H, Takeya K, Itokawa H, Pettit GR. Bufobutanoic acid and bufopyramide, two new indole alkaloids from the Chinese traditional drug Ch'an Su Heterocycles. 50: 499-503. DOI: 10.3987/Com-98-S(H)55  1
1999 Kamano Y, Kotake A, Hashima H, Hayakawa I, Hiraide H, Zhang HP, Kizu H, Komiyama K, Hayashi M, Pettit GR. Three new alkaloids, convolutamines F and G, and convolutamydine E, from the Floridian marine bryozoan Amathia convoluta Collection of Czechoslovak Chemical Communications. 64: 1147-1153. DOI: 10.1135/Cccc19991147  1
1999 Kamano Y, Nogawa T, Kotake A, Tozawa M, Pettit GR. Separation of toad poison bufadienolides by hydrophobic gel Journal of Liquid Chromatography and Related Technologies. 22: 2455-2465. DOI: 10.1081/Jlc-100101814  1
1999 Pettit GR, Xu JP, Gingrich DE, Williams MD, Doubek DL, Chapuis JC, Schmidt JM. Antineoplastic agents. Part 395. Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp Chemical Communications. 915-916. DOI: 10.1039/A902380A  1
1999 Yamashita A, Kamano Y, Nogawa T, Hiraide H, Kazama T, Tozawa M, Herald CL, Pettit GR. Thin-layer chromatography of bryostatins Journal of Planar Chromatography - Modern Tlc. 12: 336-339.  1
1999 Kamano Y, Kotake A, Nogawa T, Tozawa M, Pettit GR. Application of displacement thin-layer chromatography to toad-poison bufadienolides Journal of Planar Chromatography - Modern Tlc. 12: 120-123.  1
1998 Pettit GR, Rhodes MR, Herald DL, Chaplin DJ, Stratford MR, Hamel E, Pettit RK, Chapuis JC, Oliva D. Antineoplastic agents 393. Synthesis of the trans-isomer of combretastatin A-4 prodrug. Anti-Cancer Drug Design. 13: 981-93. PMID 10335271  1
1998 Pettit GR, Tan R, Melody N, Cichacz ZA, Herald DL, Hoard MS, Pettit RK, Chapuis JC. Antineoplastic agents. 397: Isolation and structure of sesterstatins 4 and 5 from Hyrtios erecta (the Republic of Maldives). Bioorganic & Medicinal Chemistry Letters. 8: 2093-8. PMID 9873492 DOI: 10.1016/S0960-894X(98)00373-4  1
1998 Smith AB, Lin Q, Pettit GR, Chapuis JC, Schmidt JM. Synthesis and in vitro cancer cell growth inhibitory activity of monocyclic model compounds containing spongistatin triene side-chains. Bioorganic & Medicinal Chemistry Letters. 8: 567-8. PMID 9871561 DOI: 10.1016/S0960-894X(98)00050-X  1
1998 Pettit RK, Pettit GR, Hazen KC. Specific activities of dolastatin 10 and peptide derivatives against Cryptococcus neoformans Antimicrobial Agents and Chemotherapy. 42: 2961-2965. PMID 9797233 DOI: 10.1128/Aac.42.11.2961  1
1998 Wender PA, DeBrabander J, Harran PG, Jimenez JM, Koehler MF, Lippa B, Park CM, Siedenbiedel C, Pettit GR. The design, computer modeling, solution structure, and biological evaluation of synthetic analogs of bryostatin 1. Proceedings of the National Academy of Sciences of the United States of America. 95: 6624-9. PMID 9618462 DOI: 10.1073/Pnas.95.12.6624  1
1998 Turner T, Jackson WH, Pettit GR, Wells A, Kraft AS. Treatment of human prostate cancer cells with dolastatin 10, a peptide isolated from a marine shell-less mollusc Prostate. 34: 175-181. PMID 9492845 DOI: 10.1002/(Sici)1097-0045(19980215)34:3<175::Aid-Pros4>3.0.Co;2-H  1
1998 McGown AT, Jayson G, Pettit GR, Haran MS, Ward TH, Crowther D. Bryostatin 1-tamoxifen combinations show synergistic effects on the inhibition of growth of P388 cells in vitro British Journal of Cancer. 77: 216-220. PMID 9460991 DOI: 10.1038/Bjc.1998.36  1
1998 Pettit GR, Xu JP, Hogan F, Cerny RL. Isolation and structure of dolastatin 17 Heterocycles. 47: 491-496. DOI: 10.3987/Com-97-S(N)8  1
1998 Roberson RW, Tucker B, Pettit GR. Microtubule depolymerization in Uromyces appendiculatus by three new antineoplastic drugs: Combretastatin A-4, dolastatin 10 and halichondrin B Mycological Research. 102: 378-382. DOI: 10.1017/S0953756297004930  1
1998 Wender PA, De Brabander J, Harran PG, Hinkle KW, Lippa B, Pettit GR. Synthesis and biological evaluation of fully synthetic bryostatin analogues Tetrahedron Letters. 39: 8625-8628. DOI: 10.1016/S0040-4039(98)01955-8  1
1997 Pettit RK, McAllister SC, Pettit GR, Herald CL, Johnson JM, Cichacz ZA. A broad-spectrum antifungal from the marine sponge Hyrtios erecta. International Journal of Antimicrobial Agents. 9: 147-52. PMID 9552710 DOI: 10.1016/S0924-8579(97)00044-7  0.56
1997 Pettit GR, Xu JP, Hogan F, Williams MD, Doubek DL, Schmidt JM, Cerny RL, Boyd MR. Isolation and structure of the human cancer cell growth inhibitory cyclodepsipeptide dolastatin 16. Journal of Natural Products. 60: 752-4. PMID 9287413 DOI: 10.1021/Np9700230  0.4
1997 Pettit GR, McNulty J, Herald DL, Doubek DL, Chapuis JC, Schmidt JM, Tackett LP, Boyd MR. Antineoplastic agents. 362. Isolation and X-ray crystal structure of dibromophakellstatin from the Indian ocean sponge Phakellia mauritiana. Journal of Natural Products. 60: 180-3. PMID 9051914 DOI: 10.1021/Np9606106  1
1997 Bates RB, Brusoe KG, Burns JJ, Caldera S, Cui W, Gangwar S, Gramme MR, McClure KJ, Rouen GP, Schadow H, Stessman CC, Taylor SR, Vu VH, Yarick GV, Zhang J, ... Pettit GR, et al. Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11 Journal of the American Chemical Society. 119: 2111-2113. DOI: 10.1021/Ja963857Y  1
1996 Pettit GR, Butler MS, Williams MD, Filiatrault MJ, Pettit RK. Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta Journal of Natural Products. 59: 927-934. PMID 8904842 DOI: 10.1021/Np960249N  1
1996 Pettit GR, Gao F, Blumberg PM, Herald CL, Coll JC, Kamano Y, Lewin NE, Schmidt JM, Chapuis JC. Antineoplastic agents. 340. Isolation and structural elucidation of bryostatins 16-18. Journal of Natural Products. 59: 286-9. PMID 8882431 DOI: 10.1021/Np960100B  1
1996 Pettit GR, Hoard MS, Doubek DL, Schmidt JM, Pettit RK, Tackett LP, Chapuis JC. Antineoplastic agents 338. The cancer cell growth inhibitory. Constituents of Terminalia arjuna (Combretaceae). Journal of Ethnopharmacology. 53: 57-63. PMID 8844460 DOI: 10.1016/S0378-8741(96)01421-3  1
1996 McBain JA, Eastman A, Simmons DL, Pettit GR, Mueller GC. Phorbol ester augments butyrate-induced apoptosis of colon cancer cells International Journal of Cancer. 67: 715-723. PMID 8782664 DOI: 10.1002/(Sici)1097-0215(19960904)67:5<715::Aid-Ijc21>3.0.Co;2-2  1
1996 Kraft AS, Woodley S, Pettit GR, Gao F, Coll JC, Wagner F. Comparison of the antitumor activity of bryostatins 1, 5, and 8. Cancer Chemotherapy and Pharmacology. 37: 271-8. PMID 8529289 DOI: 10.1007/Bf00688328  1
1996 Pettit GR, Taylor SR. Synthesis of the marine sponge cycloheptapeptide stylopeptide 1 Journal of Organic Chemistry. 61: 2322-2325. DOI: 10.1021/Jo951986B  1
1995 Bai R, Taylor GF, Cichacz ZA, Herald CL, Kepler JA, Pettit GR, Hamel E. The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain. Biochemistry. 34: 9714-21. PMID 7626642 DOI: 10.1021/Bi00030A009  1
1995 Pettit GR, Butler MS, Bass CG, Doubek DL, Williams MD, Schmidt JM, Pettit RK, Hooper JNA, Tackett LP, Filiatrault MJ. Antineoplastic agents, 326. The stereochemistry of bastadins 8, 10, and 12 from the Bismarck Archipelago marine sponge Ianthella basta Journal of Natural Products (Lloydia). 58: 680-688. PMID 7623047 DOI: 10.1021/Np50119A005  1
1995 Pettit GR, Ichihara Y, Wurzel G, Williams MD, Schmidt JM, Chapuis JC. Isolation and structure of halistatin 3 from the Western Pacific (Chuuk) marine sponge Phakellia sp Journal of the Chemical Society, Chemical Communications. 383-385. DOI: 10.1039/C39950000383  1
1995 Pettit GR, Xu JP, Schmidt JM, Boyd MR. Isolation and structure of the exceptional Pterobranchia human cancer inhibitors cephalostatins 16 and 171 Bioorganic and Medicinal Chemistry Letters. 5: 2027-2032. DOI: 10.1016/0960-894X(95)00346-U  1
1994 Pettit GR, Gao F, Cerny RL, Doubek DL, Tackett LP, Schmidt JM, Chapuis JC. Antineoplastic agents. 278. Isolation and structure of axinastatins 2 and 3 from a western Caroline Island marine sponge. Journal of Medicinal Chemistry. 37: 1165-8. PMID 8164258 DOI: 10.1021/Jm00034A014  1
1994 Pettit GR, Xu JP, Williams MD, Christie ND, Doubek DL, Schmidt JM, Boyd MR. Isolation and structure of cephalostatins 10 and 11. Journal of Natural Products. 57: 52-63. PMID 8158165 DOI: 10.1021/Np50103A007  0.32
1994 David Jarvis W, Povirk LF, Turner AJ, Traylor RS, Gewirtz DA, Pettit GR, Grant S. Effects of bryostatin 1 and other pharmacological activators of protein kinase C on 1-[β-d-arabinofuranosyl]cytosine-induced apoptosis in HL-60 human promyelocytic leukemia cells Biochemical Pharmacology. 47: 839-852. PMID 8135859 DOI: 10.1016/0006-2952(94)90484-7  1
1994 Pettit GR, Kantoci D, Herald DL, Barkoczy J, Slack JA. Procedures for the analyses of dolastatins 10 and 15 by high performance liquid chromatography1 Journal of Liquid Chromatography. 17: 191-202. DOI: 10.1080/10826079408013444  1
1994 Pettit GR, Gao F, Schmidt JM, Chapuis JC, Cerny RL. Isolation and structure of axinastatin 5 from a republic of comoros marine sponge Bioorganic and Medicinal Chemistry Letters. 4: 2935-2940. DOI: 10.1016/S0960-894X(01)80843-X  1
1993 Bai R, Roach MC, Jayaram SK, Barkoczy J, Pettit GR, Luduena RF, Hamel E. Differential effects of active isomers, segments, and analogs of dolastatin 10 on ligand interactions with tubulin. Correlation with cytotoxicity Biochemical Pharmacology. 45: 1503-1515. PMID 8471072 DOI: 10.1016/0006-2952(93)90051-W  1
1993 Luduena RF, Roach MC, Prasad V, Pettit GR. Interaction of halichondrin B and homohalichondrin B with bovine brain tubulin Biochemical Pharmacology. 45: 421-427. PMID 8435093 DOI: 10.1016/0006-2952(93)90079-C  1
1993 Philip PA, Rea D, Thavasu P, Carmichael J, Stuart NS, Rockett H, Talbot DC, Ganesan T, Pettit GR, Balkwill F. Phase I study of bryostatin 1: assessment of interleukin 6 and tumor necrosis factor alpha induction in vivo. The Cancer Research Campaign Phase I Committee. Journal of the National Cancer Institute. 85: 1812-8. PMID 8230261 DOI: 10.1093/Jnci/85.22.1812  1
1993 Grant S, Traylor R, Pettit GR, Lin PS. Modulation by bryostatin 1 of the in vitro radioprotective effects of the GM-CSF/IL-3 fusion protein, PIXY 321, on normal human myeloid progenitors Cytokine. 5: 490-497. PMID 8142605 DOI: 10.1016/1043-4666(93)90040-C  1
1992 Luduena RF, Roach MC, Prasad V, Pettit GR. Interaction of dolastatin 10 with bovine brain tubulin Biochemical Pharmacology. 43: 539-543. PMID 1540211 DOI: 10.1016/0006-2952(92)90576-5  1
1992 Watters DJ, Michael J, Hemphill JE, Hamilton SE, Lavin MF, Pettit GR. Bistratene A: A novel compound causing changes in protein phosphorylation patterns in human leukemia cells Journal of Cellular Biochemistry. 49: 417-424. PMID 1429868 DOI: 10.1002/Jcb.240490412  1
1991 Djerassi C, Pettit GR, Herald DL, Sanson DR. Arylmagnesium bromide additions to 1-tetralone-2-acetic acid followed by catalytic hydrogenolysis: Stereochemical consequences Journal of Organic Chemistry. 56: 5360-5368. DOI: 10.1021/Jo00018A030  1
1991 Kerr RG, Kerr SL, Pettit GR, Herald DL, Groy TL, Djerassi C. Sterols of marine invertebrates. 63. Isolation and structure elucidation of sutinasterol, the major sterol of the marine sponge Xestospongia sp. Journal of Organic Chemistry. 56: 58-62. DOI: 10.1021/Jo00001A013  1
1990 Pettit GR, Rideout JA, Hasler JA. Isolation of geodiatoxins 2-4 from the marine sponge Geodia mesotriaena Comparative Biochemistry and Physiology. Part C, Comparative. 96: 305-306. PMID 1980442 DOI: 10.1016/0742-8413(90)90012-X  1
1989 Baer JC, Slack JA, Pettit GR. Stability-indicating high-performance liquid chromatography assay for the anticancer drug bryostatin 1 Journal of Chromatography A. 467: 332-335. PMID 2753943 DOI: 10.1016/S0021-9673(01)93983-4  1
1989 Jetten AM, George MA, Pettit GR, Herald CL, Rearick JI. Action of phorbol esters, bryostatins, and retinoic acid on cholesterol sulfate synthesis: Relation to the multistep process of differentiation in human epidermal keratinocytes Journal of Investigative Dermatology. 93: 108-115. PMID 2473132 DOI: 10.1111/1523-1747.Ep12277374  1
1989 Pettit GR, Kamano Y, Schaufelberger D, Herald CL, Blumberg PM, May SW. High performance liquid chromatographic separation of bryostatins 1–12 Journal of Liquid Chromatography. 12: 553-561. DOI: 10.1080/01483918908051757  1
1988 Warren JT, Esa AH, Pettit GR, May WS. Bryostatin stimulation of human neutrophil luminol and DBA (lucigenin) chemiluminescence Basic Life Sciences. 49: 223-227. PMID 3250479 DOI: 10.1007/978-1-4684-5568-7_34  1
1988 Wender PA, Cribbs CM, Koehler KF, Sharkey NA, Herald CL, Kamano Y, Pettit GR, Blumberg PM. Modeling of the bryostatins to the phorbol ester pharmacophore on protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 85: 7197-201. PMID 3174627 DOI: 10.1073/Pnas.85.19.7197  1
1988 Parker J, Waite M, Pettit GR, Daniel LW. Stimulation of arachidonic acid release and prostaglandin synthesis by bryostatin 1 Carcinogenesis. 9: 1471-1474. PMID 3135956 DOI: 10.1093/Carcin/9.8.1471  1
1986 Pettit GR, Herald DL, Herald CL, Kokke WC, Djerassi C. The crystal structure of 3 beta-hydroxy-4 alpha, 23R, 24R-trimethyl-5 alpha-cholestane (23R, 24R-5 alpha-dinostanol) from dinoflagellates. Steroids. 47: 321-6. PMID 3590242 DOI: 10.1016/0039-128X(86)90101-7  1
1985 Piatak DM, Patel J, Totten CE, Swenson RP, Brown P, Pettit GR. Cell growth inhibitory glycosides from Asclepias amplexicaulis. Journal of Natural Products. 48: 470-1. PMID 4031902  1
1983 Pettit GR, Barton DH, Herald CL, Polonsky J, Schmidt JM, Connolly JD. Evaluation of limonoids against the murine P388 lymphocytic leukemia cell line. Journal of Natural Products. 46: 379-90. PMID 6619886 DOI: 10.1021/Np50027A015  0.56
1980 Pettit GR, Herald CL, Ode RH, Brown P, Gust DJ, Michel C. The isolation of loliolide from an Indian Ocean opisthobranch mollusc. Journal of Natural Products. 43: 752-5. PMID 20707399 DOI: 10.1021/Np50012A009  0.56
1980 Polonsky J, Varon Z, Moretti C, Pettit GR, Herald CL, Rideout JA, Saha SB, Khastgir HN. The antineoplastic quassinoids of Simaba cuspidata spruce and Ailanthus grandis Prain. Journal of Natural Products. 43: 503-9. PMID 7431025 DOI: 10.1021/Np50010A012  0.56
1979 Pettit GR, Smith TH. Structural biochemistry XIII: Synthesis of luteinizing hormone‐releasing hormone modification [Trp8]‐LH‐RH Journal of Pharmaceutical Sciences. 68: 1013-1015. PMID 383947 DOI: 10.1002/Jps.2600680825  1
1978 Polonsky J, Varon Z, Jacquemin H, Pettit GR. The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara. Experientia. 34: 1122-3. PMID 720499 DOI: 10.1007/BF01922904  1
1978 Schmidt JM, Pettit GR. Presence of oncornavirus-like particles in the P388 murine leukemic cell line Experientia. 34: 659-660. PMID 658262 DOI: 10.1007/Bf01937017  1
1977 Pettit GR, Herald CL, Allen MS, von Dreele RB, Vanell LD, Kao JP, Blake W. The isolation and structure of aplysistatin. Journal of the American Chemical Society. 99: 262-3. PMID 830682 DOI: 10.1021/Ja00443A055  1
1975 Pettit GR, Herald CL, Judd GF, Bolliger G, Thayer PS. Antineoplastic and cytotoxic components of desert Baileya Journal of Pharmaceutical Sciences. 64: 2023-2024. PMID 1239501 DOI: 10.1002/Jps.2600641232  1
1975 Pettit GR, Einck JJ, Herald CL, Ode RH, Von Dreele RB, Brown P, Brazhnikova MG, Gause GF. Letter: The structure of carminomycin I. Journal of the American Chemical Society. 97: 7387-8. PMID 1194606 DOI: 10.1021/Ja00858A036  1
1975 Von Dreele RB, Pettit GR, Ode RH, Perdue RE, White JD, Manchand PS. The crystal and molecular structure of the unusual spiro dihydrofuran diterpene nepetaefolin. Journal of the American Chemical Society. 97: 6236-40. PMID 1176729 DOI: 10.1021/Ja00854A049  1
1974 Pettit GR, Saldana EI. Antineoplastic agents. 36. Acetylenic carrier groups. Journal of Medicinal Chemistry. 17: 896-8. PMID 4845382 DOI: 10.1021/Jm00254A024  1
1973 Pettit GR, von Dreele RB, Bollinger G, Traxler PM, Brown P. Isolation and structural elucidation of 3,6-dioxo-hexahydro-pyrrolo (1,2-a)-pyrazine from the echinoderm Luidia clathrata. Experientia. 29: 521-2. PMID 4730273 DOI: 10.1007/Bf01926639  1
1972 Pettit GR, Quinn RJ, Smith TH, Brown P, Cheng CC, O'Brien DE, Haggerty WJ, Salerni OL. The camptothecin δ-lactone Journal of Organic Chemistry. 37: 2789-2791. PMID 5054516 DOI: 10.1021/Jo00982A048  1
1972 Pettit GR, Houghton LE, Rogers NH, Coomes RM, Berger DF, Reucroft PR, Day JF, Hartwell JL, Wood HB. Butterfly wing antineoplastic agents. Experientia. 28: 381-2. PMID 5036539 DOI: 10.1007/Bf02008286  1
1972 Pettit GR, Dias JR. Steroids and related natural products. 66. Structural modification of the triterpene A ring Journal of Organic Chemistry. 37: 973-976. PMID 5016333 DOI: 10.1021/Jo00972A011  1
1971 Pettit GR, Dias JR. Bufadienolides. 13. Conversion of 3β-hydroxy-17-oxoandrost-5-ene to 3β-acetoxy-5β,14α-bufa-20,22-dienolide Journal of Organic Chemistry. 36: 3207-3211. PMID 4257389 DOI: 10.1021/Jo00820A028  1
1970 Pettit GR, Kasturi TR. Steroids and related natural products. 63. 17-beta-acetoxy-4-oxa-2-androstene. Journal of Medicinal Chemistry. 13: 1244-5. PMID 5479881 DOI: 10.1021/Jm00300A060  1
1970 Pettit GR, Kasturi TR, Knight JC, Occolowitz J. Bufadienolides. 8. 12(13--14)abeo skeletal rearrangements. The Journal of Organic Chemistry. 35: 1404-10. PMID 5462268 DOI: 10.1021/Jo00830A032  1
1970 Pettit GR, Kasturi TR, Knight JC, Jaeggi KA. Bufadienolides. 9. Isobufalin. The Journal of Organic Chemistry. 35: 1410-4. PMID 5440329 DOI: 10.1021/Jo00830A033  1
1970 Pettit GR, Green B, Das Gupta AK, Whitehouse PA, Yardley JP. Bufadienolides. 3. A synthetic route to isocardenolides Journal of Organic Chemistry. 35: 1381-1384. PMID 5440326 DOI: 10.1021/Jo00830A027  1
1970 Pettit GR, Dias JR. Conversion of steroidal δ-lactones into dihydropyrans or tetrahydropyrans Journal of the Chemical Society D: Chemical Communications. 901-902. DOI: 10.1039/C29700000901  1
1964 Pettit GR, Das Gupta AK, Klinger H, Occolowitz J. Steroidal peptides. Experientia. 20: 545-6. PMID 5859208 DOI: 10.1007/BF02150279  0.48
1964 Kutney JP, Cretney W, Pettit GR, Knight JC. Structure and stereochemistry of the monobromotigogenins Tetrahedron. 20: 1999-2006. DOI: 10.1016/S0040-4020(01)98471-6  1
1959 DJERASSI C, HALPERN O, PETTIT GR, THOMAS GH. Reaction of the Steroidal Sapogenin Spiroketal System with Ethanedithiol1 The Journal of Organic Chemistry. 24: 1-6. DOI: 10.1021/Jo01083A001  1
1957 DJERASSI C, PETTIT GR. Steric Requirements in the Cyclization of Naphthalene Derivatives The Journal of Organic Chemistry. 22: 393-396. DOI: 10.1021/Jo01355A012  1
1954 Djerassi C, Pettit GR. The Reaction of α-Halo Ketones with 2-Pyridinethiol1 Journal of the American Chemical Society. 76: 4470-4472. DOI: 10.1021/Ja01646A057  1
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